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Original Research

Bortezomib-based therapy for transplant-ineligible East Asian patients with newly diagnosed mantle-cell lymphoma

, , , , , , , , , & show all
Pages 3869-3882 | Published online: 06 Jul 2018

Figures & data

Table 1 Patient demographics and baseline characteristics (intent-to-treat population)

Table 2 Treatment exposure

Figure 1 Kaplan–Meier analysis of progression-free survival in the East Asian population.

Notes: (A) Independent Radiology Review Committee; (B) investigator assessment.
Abbreviations: R-CHOP, rituximab + cyclophosphamide, doxorubicin, vincristine, prednisone; VR-CAP, bortezomib, rituximab, cyclophosphamide, doxorubicin, prednisone.
Figure 1 Kaplan–Meier analysis of progression-free survival in the East Asian population.

Table 3 Response rates in VR-CAP versus R-CHOP arms by Independent Radiology Review Committee and investigator assessment

Figure 2 Kaplan–Meier analysis of (A) time to next antilymphoma therapy and (B) overall survival, in the East Asian population (intent-to-treat population).

Abbreviations: R-CHOP, rituximab + cyclophosphamide, doxorubicin, vincristine, prednisone; VR-CAP, bortezomib, rituximab, cyclophosphamide, doxorubicin, prednisone.
Figure 2 Kaplan–Meier analysis of (A) time to next antilymphoma therapy and (B) overall survival, in the East Asian population (intent-to-treat population).

Table 4 Most common adverse events (safety populationTable Footnotea)

Table 5 Adverse events of clinical interest: thrombocytopenia, neutropenia, and peripheral neuropathy (safety population)

Table S1 Institutional review boards (IRBs) and ethics committees (ECs)

Figure S1 Patient disposition (CONSORT diagram).

Abbreviations: VR-CAP, bortezomib, rituximab, cyclophosphamide, doxorubicin, prednisone; R-CHOP, rituximab + cyclophosphamide, doxorubicin, vincristine, prednisone.
Figure S1 Patient disposition (CONSORT diagram).