OncoTargets and Therapy, Volume 11, Issue (2018)

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OncoTargets and Therapy, Volume 11, Issue (2018)

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Original Research

Article
ERCC1 rs3212986 A/C polymorphism is not associated with chemotherapy treatment outcomes in gastric cancer patients: evidence from 11 publications in Chinese populations
Weiwei Tang, Hanjin Wang, Yuemei Wang & Xiaowei Wang
Pages: 1-8
Published online: 20 Dec 2017
AbstractforERCC1 rs3212986 A/C polymorphism is not associated with chemotherapy treatment outcomes in gastric cancer patients: evidence from 11 publications in Chinese populations | Full Text | References | PDF (850 KB)
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Open Access
Article
Identification of epigenetically altered genes and potential gene targets in melanoma using bioinformatic methods
Honghao Duan, Ke Jiang, Dengke Wei, Lijun Zhang, Deliang Cheng, Min Lv, Yuben Xu & Aimin He
Pages: 9-15
Published online: 20 Dec 2017
AbstractforIdentification of epigenetically altered genes and potential gene targets in melanoma using bioinformatic methods | Full Text | References | PDF (781.6 KB)
  • 64 Views
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Open Access
Article
Quercetin suppresses DNA double-strand break repair and enhances the radiosensitivity of human ovarian cancer cells via p53-dependent endoplasmic reticulum stress pathway
Cheng Gong, Zongyuan Yang, Lingyun Zhang, Yuehua Wang, Wei Gong & Yi Liu
Pages: 17-27
Published online: 21 Dec 2017
AbstractforQuercetin suppresses DNA double-strand break repair and enhances the radiosensitivity of human ovarian cancer cells via p53-dependent endoplasmic reticulum stress pathway | Full Text | References | PDF (5.9 MB)
  • 198 Views
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Open Access
Article
Four-miRNA signature as a prognostic tool for lung adenocarcinoma
Yan Lin, Yufeng Lv, Rong Liang, Chunling Yuan, Jinyan Zhang, Dan He, Xiaowen Zheng & Jianfeng Zhang
Pages: 29-36
Published online: 21 Dec 2017
AbstractforFour-miRNA signature as a prognostic tool for lung adenocarcinoma | Full Text | References | PDF (1.5 MB)
  • 85 Views
  • 19 CrossRef citations
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Open Access
Article
Upregulated LAMB3 increases proliferation and metastasis in thyroid cancer
Yinghao Wang, Yixiang Jin, Adheesh Bhandari, Zhihan Yao, Fan Yang, Yiyuan Pan, Zhouci Zheng, Shixu Lv & Ouchen Wang
Pages: 37-46
Published online: 21 Dec 2017
AbstractforUpregulated LAMB3 increases proliferation and metastasis in thyroid cancer | Full Text | References | PDF (3.2 MB)
  • 105 Views
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Open Access

Review

Review Article
Clinicopathological and prognostic significance of OCT4 in patients with hepatocellular carcinoma: a meta-analysis
Chaojie Liang, Yingchen Xu, Hua Ge, Guangming Li & Jixiang Wu
Pages: 47-57
Published online: 21 Dec 2017
AbstractforClinicopathological and prognostic significance of OCT4 in patients with hepatocellular carcinoma: a meta-analysis | Full Text | References | PDF (1.2 MB)
  • 47 Views
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Open Access

Original Research

Article
Pretreatment platelet count as a prognostic factor in patients with pancreatic cancer: a systematic review and meta-analysis
Sheng Chen, Ning Na & Zhixiang Jian
Pages: 59-65
Published online: 21 Dec 2017
AbstractforPretreatment platelet count as a prognostic factor in patients with pancreatic cancer: a systematic review and meta-analysis | Full Text | References | PDF (688.3 KB)
  • 70 Views
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Open Access
Article
RETRACTED ARTICLE: miR-136 targets MIEN1 and involves the metastasis of colon cancer by suppressing epithelial-to-mesenchymal transition
Haipeng Ren, Yuanling Qi, Xiaoyan Yin & Jianfeng Gao
Pages: 67-74
Published online: 22 Dec 2017
AbstractforRETRACTED ARTICLE: miR-136 targets MIEN1 and involves the metastasis of colon cancer by suppressing epithelial-to-mesenchymal transition | PDF (1.3 MB)
  • 55 Views
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Open Access
Article
Real-world usage and clinical outcomes of alectinib among post-crizotinib progression anaplastic lymphoma kinase positive non-small-cell lung cancer patients in the USA
Marco D DiBonaventura, William Wong, Bijal Shah-Manek & Mathias Schulz
Pages: 75-82
Published online: 22 Dec 2017
AbstractforReal-world usage and clinical outcomes of alectinib among post-crizotinib progression anaplastic lymphoma kinase positive non-small-cell lung cancer patients in the USA | Full Text | References | PDF (302.2 KB)
  • 72 Views
  • 5 CrossRef citations
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Open Access
Article
Prognosis of patients with primary malignant main stem bronchial tumors: 7,418 cases based on the SEER database
Ke Ma, Fenghao Sun, Xiaodong Yang, Shuai Wang, Lin Wang, Yulin Jin, Yu Shi, Wei Jiang, Cheng Zhan & Qun Wang
Pages: 83-95
Published online: 22 Dec 2017
AbstractforPrognosis of patients with primary malignant main stem bronchial tumors: 7,418 cases based on the SEER database | Full Text | References | PDF (2 MB)
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Open Access

Review

Review Article
The RNASEL –1385G/A polymorphism is associated with risk of prostate cancer in Africans
Xiaolei Liu, Dejie Zheng, Guowei Lu & Baohong Yang
Pages: 97-102
Published online: 22 Dec 2017
AbstractforThe RNASEL –1385G/A polymorphism is associated with risk of prostate cancer in Africans | Full Text | References | PDF (592.1 KB)
  • 56 Views
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Open Access

Original Research

Article
The putative tumor suppressor, miR-199a, regulated by Snail, modulates clear cell renal cell carcinoma aggressiveness by repressing ROCK1
Xiao Zhang, Peng Li, Zhen Ding, Huili Wang, Junye Wang, Lei Han & Shangwei Ding
Pages: 103-112
Published online: 27 Dec 2017
AbstractforThe putative tumor suppressor, miR-199a, regulated by Snail, modulates clear cell renal cell carcinoma aggressiveness by repressing ROCK1 | Full Text | References | PDF (1.9 MB)
  • 52 Views
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Open Access
Article
A retrospective examination of the US Food and Drug Administration’s clinical pharmacology reviews of oncology biologics for potential use of therapeutic drug monitoring
Brett Fleisher & Sihem Ait-Oudhia
Pages: 113-121
Published online: 27 Dec 2017
AbstractforA retrospective examination of the US Food and Drug Administration’s clinical pharmacology reviews of oncology biologics for potential use of therapeutic drug monitoring | Full Text | References | PDF (426 KB)
  • 130 Views
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Open Access
Article
Assessment of the cardiac safety between cetuximab and panitumumab as single therapy in Chinese chemotherapy-refractory mCRC
Xue-miao Tang, Hao Chen, Qing Li, Yiling Song, Shuping Zhang, Xiao-Shuan Xu, Yiwei Xu & Shulin Chen
Pages: 123-129
Published online: 28 Dec 2017
AbstractforAssessment of the cardiac safety between cetuximab and panitumumab as single therapy in Chinese chemotherapy-refractory mCRC | Full Text | References | PDF (553.3 KB)
  • 57 Views
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Open Access

Review

Review Article
Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy
Germana Castelli, Elvira Pelosi & Ugo Testa
Pages: 131-155
Published online: 28 Dec 2017
AbstractforTargeting histone methyltransferase and demethylase in acute myeloid leukemia therapy | Full Text | References | PDF (673.8 KB)
  • 154 Views
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Open Access

Case Report

Case Report
A patient with classic biphasic pulmonary blastoma harboring CD74–ROS1 fusion responds to crizotinib
Zhaoting Meng, Peng Chen, Fenglin Zang, Ying Liu, Xiaoyan Xu, Yudong Su, Jinliang Chen, Li Lin, Lu Zhang & Tengfei Zhang
Pages: 157-161
Published online: 28 Dec 2017
AbstractforA patient with classic biphasic pulmonary blastoma harboring CD74–ROS1 fusion responds to crizotinib | Full Text | References | PDF (3.1 MB)
  • 48 Views
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Open Access

Original Research

Article
Identification of key pathways and genes in TP53 mutation acute myeloid leukemia: evidence from bioinformatics analysis
Rui Huang, Xiwen Liao & Qiaochuan Li
Pages: 163-173
Published online: 28 Dec 2017
AbstractforIdentification of key pathways and genes in TP53 mutation acute myeloid leukemia: evidence from bioinformatics analysis | Full Text | References | PDF (7.5 MB)
  • 298 Views
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Open Access

Review

Review Article
Spotlight on midostaurin in the treatment of FLT3-mutated acute myeloid leukemia and systemic mastocytosis: design, development, and potential place in therapy
Ellen Weisberg, Martin Sattler, Paul W Manley & James D Griffin
Pages: 175-182
Published online: 14 Nov 2022
AbstractforSpotlight on midostaurin in the treatment of FLT3-mutated acute myeloid leukemia and systemic mastocytosis: design, development, and potential place in therapy | Full Text | References | PDF (368.6 KB)
  • 108 Views
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Open Access

Editorial

Editorial
Cancer stem cells, the ultimate targets in cancer therapy
Ahmed Shabbir, Tuba Esfandyari & Faris Farassati
Pages: 183-184
Published online: 03 Jan 2018
CitationforCancer stem cells, the ultimate targets in cancer therapy | Full Text | References | PDF (232.4 KB)
  • 56 Views
  • 1 CrossRef citations
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Open Access

Original Research

Article
The effects of naloxone on human breast cancer progression: in vitro and in vivo studies on MDA.MB231 cells
Sabrina Bimonte, Antonio Barbieri, Marco Cascella, Domenica Rea, Giuseppe Palma, Vitale Del Vecchio, Cira Antonietta Forte, Francesco Del Prato, Claudio Arra & Arturo Cuomo
Pages: 185-191
Published online: 14 Nov 2022
AbstractforThe effects of naloxone on human breast cancer progression: in vitro and in vivo studies on MDA.MB231 cells | Full Text | References | PDF (1.3 MB)
  • 120 Views
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Open Access
Article
Autophagy suppresses proliferation of HepG2 cells via inhibiting glypican-3/wnt/β-catenin signaling
Pei Hu, Bin Cheng, Yulin He, Zhiqiang Wei, Dongfang Wu & Zhongji Meng
Pages: 193-200
Published online: 04 Jan 2018
AbstractforAutophagy suppresses proliferation of HepG2 cells via inhibiting glypican-3/wnt/β-catenin signaling | Full Text | References | PDF (1.9 MB)
  • 123 Views
  • 12 CrossRef citations
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Open Access
Article
KDM2B overexpression correlates with poor prognosis and regulates glioma cell growth
Yiwei Wang, Jin Zang, Dongyong Zhang, Zhenxiang Sun, Bo Qiu & Xiaojie Wang
Pages: 201-209
Published online: 08 Jan 2018
AbstractforKDM2B overexpression correlates with poor prognosis and regulates glioma cell growth | Full Text | References | PDF (3 MB)
  • 70 Views
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Open Access
Article
RACKI induces chemotherapy resistance in esophageal carcinoma by upregulating the PI3K/AKT pathway and Bcl-2 expression
Bowen Liu, Cong Wang, Pengxiang Chen, Bo Cheng & Yufeng Cheng
Pages: 211-220
Published online: 04 Jan 2018
AbstractforRACKI induces chemotherapy resistance in esophageal carcinoma by upregulating the PI3K/AKT pathway and Bcl-2 expression | Full Text | References | PDF (10 MB)
  • 69 Views
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Open Access
Article
Transcriptional profiling of NCI/ADR-RES cells unveils a complex network of signaling pathways and molecular mechanisms of drug resistance
Anna Vert, Jessica Castro, Marc Ribó, Maria Vilanova & Antoni Benito
Pages: 221-237
Published online: 04 Jan 2018
AbstractforTranscriptional profiling of NCI/ADR-RES cells unveils a complex network of signaling pathways and molecular mechanisms of drug resistance | Full Text | References | PDF (1.1 MB)
  • 105 Views
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Open Access
Article
miR-99a-5p acts as tumor suppressor via targeting to mTOR and enhances RAD001-induced apoptosis in human urinary bladder urothelial carcinoma cells
Te-Fu Tsai, Ji-Fan Lin, Kuang-Yu Chou, Yi-Chia Lin, Hung-En Chen & Thomas I-Sheng Hwang
Pages: 239-252
Published online: 04 Jan 2018
AbstractformiR-99a-5p acts as tumor suppressor via targeting to mTOR and enhances RAD001-induced apoptosis in human urinary bladder urothelial carcinoma cells | Full Text | References | PDF (4.1 MB)
  • 92 Views
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Open Access
Article
A support vector machine and a random forest classifier indicates a 15-miRNA set related to osteosarcoma recurrence
Yunfei He, Jun Ma, An Wang, Weiheng Wang, Shengchang Luo, Yaoming Liu & Xiaojian Ye
Pages: 253-269
Published online: 14 Nov 2022
AbstractforA support vector machine and a random forest classifier indicates a 15-miRNA set related to osteosarcoma recurrence | Full Text | References | PDF (3.8 MB)
  • 75 Views
  • 17 CrossRef citations
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Open Access
Article
Experimental study of inhibitory effects of diallyl trisulfide on the growth of human osteosarcoma Saos-2 cells by downregulating expression of glucose-regulated protein 78
Yue Zhang, Wen-Peng Xie, Yong-Kui Zhang, Yi-Qiang Chen, Dong-Li Wang, Gang Li & Dong-Hui Guan
Pages: 271-277
Published online: 09 Jan 2018
AbstractforExperimental study of inhibitory effects of diallyl trisulfide on the growth of human osteosarcoma Saos-2 cells by downregulating expression of glucose-regulated protein 78 | Full Text | References | PDF (3.2 MB)
  • 61 Views
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Open Access
Article
Over-expression of ARHGAP18 suppressed cell proliferation, migration, invasion, and tumor growth in gastric cancer by restraining over-activation of MAPK signaling pathways
Yan Li, Shan Ji, Liye Fu, Tao Jiang, Di Wu & Fandong Meng
Pages: 279-290
Published online: 09 Jan 2018
AbstractforOver-expression of ARHGAP18 suppressed cell proliferation, migration, invasion, and tumor growth in gastric cancer by restraining over-activation of MAPK signaling pathways | Full Text | References | PDF (2.4 MB)
  • 70 Views
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Open Access
Article
Exosome-mediated delivery of MALAT1 induces cell proliferation in breast cancer
Ping Zhang, Hongxing Zhou, Kefeng Lu, Yunou Lu, Yan Wang & Tongbao Feng
Pages: 291-299
Published online: 09 Jan 2018
AbstractforExosome-mediated delivery of MALAT1 induces cell proliferation in breast cancer | Full Text | References | PDF (1.2 MB)
  • 289 Views
  • 71 CrossRef citations
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Open Access
Article
Comparative study of clinical efficacy using three-dimensional and two-dimensional laparoscopies in the treatment of distal gastric cancer
Jungang Liu, Haitao Zhou, Haiquan Qin, Haiming Ru, Jiahao Huang, Siyuan Liang, Xianwei Mo & Weizhong Tang
Pages: 301-306
Published online: 11 Jan 2018
AbstractforComparative study of clinical efficacy using three-dimensional and two-dimensional laparoscopies in the treatment of distal gastric cancer | Full Text | References | PDF (274.6 KB)
  • 74 Views
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Open Access
Article
A novel tumor suppressor gene NCOA5 is correlated with progression in papillary thyroid carcinoma
Zhou-Ci Zheng, Qing-Xuan Wang, Wei Zhang, Xiao-Hua Zhang & Du-Ping Huang
Pages: 307-311
Published online: 11 Jan 2018
AbstractforA novel tumor suppressor gene NCOA5 is correlated with progression in papillary thyroid carcinoma | Full Text | References | PDF (522.9 KB)
  • 71 Views
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Open Access
Article
RETRACTED ARTICLE: The silencing of LncRNA-H19 decreases chemoresistance of human glioma cells to temozolomide by suppressing epithelial-mesenchymal transition via the Wnt/β-Catenin pathway
Linwei Jia, Yaohui Tian, Yonghan Chen & Gang Zhang
Pages: 313-321
Published online: 11 Jan 2018
AbstractforRETRACTED ARTICLE: The silencing of LncRNA-H19 decreases chemoresistance of human glioma cells to temozolomide by suppressing epithelial-mesenchymal transition via the Wnt/β-Catenin pathway | PDF (5.3 MB)
  • 27 Views
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Open Access
Article
High-frequency deregulated expression of Wnt signaling pathway members in breast carcinomas
Zahid Khan, Maha Arafah, Jilani Purusottapatnam Shaik, Alka Mahale & Mohammad Saud Alanazi
Pages: 323-335
Published online: 11 Jan 2018
AbstractforHigh-frequency deregulated expression of Wnt signaling pathway members in breast carcinomas | Full Text | References | PDF (2.7 MB)
  • 74 Views
  • 12 CrossRef citations
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Open Access
Article
The clinical characteristics and prognostic analysis of Chinese advanced NSCLC patients based on circulating tumor DNA sequencing
Chuangzhou Rao, Liangqin Nie, Xiaobo Miao, Yunbao Xu, Bing Li & Tengfei Zhang
Pages: 337-344
Published online: 12 Jan 2018
AbstractforThe clinical characteristics and prognostic analysis of Chinese advanced NSCLC patients based on circulating tumor DNA sequencing | Full Text | References | PDF (1.5 MB)
  • 55 Views
  • 4 CrossRef citations
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Open Access
Article
Safety and efficacy of transarterial chemoembolization with degradable starch microspheres (DSM-TACE) in the treatment of secondary liver malignancies
Andreas Schicho, Philippe L Pereira, Katharina Michalik, Lukas P Beyer, Christian Stroszczynski & Philipp Wiggermann
Pages: 345-350
Published online: 12 Jan 2018
AbstractforSafety and efficacy of transarterial chemoembolization with degradable starch microspheres (DSM-TACE) in the treatment of secondary liver malignancies | Full Text | References | PDF (450 KB)
  • 75 Views
  • 10 CrossRef citations
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Open Access
Article
Prognostic role of HSPs in human gastrointestinal cancer: a systematic review and meta-analysis
Hua Ge, Yan Yan, Lingfei Guo, Fei Tian & Di Wu
Pages: 351-359
Published online: 15 Jan 2018
AbstractforPrognostic role of HSPs in human gastrointestinal cancer: a systematic review and meta-analysis | Full Text | References | PDF (669.5 KB)
  • 57 Views
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Open Access
Article
Combination of betulinic acid with diazen-1-ium-1,2-diolate nitric oxide moiety donating a novel anticancer candidate
Laiyin Zhang, Shuangxing Hou, Bo Li, Jianjian Pan, Liping Jiang, Guiying Zhou, Hong Gu, Caixing Zhao, Huiping Lu & Fenfen Ma
Pages: 361-373
Published online: 14 Nov 2022
AbstractforCombination of betulinic acid with diazen-1-ium-1,2-diolate nitric oxide moiety donating a novel anticancer candidate | Full Text | References | PDF (2.1 MB)
  • 65 Views
  • 15 CrossRef citations
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Open Access
Article
Comparison of FOLFOX and DOF regimens as first-line treatment in East Asian patients with advanced gastric cancer
Mengyao Liu, Guofang Hu, Yuan Wang, Jun Guo, Liyan Liu, Xiao Han & Zhehai Wang
Pages: 375-381
Published online: 17 Jan 2018
AbstractforComparison of FOLFOX and DOF regimens as first-line treatment in East Asian patients with advanced gastric cancer | Full Text | References | PDF (636.2 KB)
  • 64 Views
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Open Access
Article
Prognostic role of HSF1 overexpression in solid tumors: a pooled analysis of 3,159 patients
Tao Wan, Jing Shao, Bin Hu, Gang Liu, Peng Luo & Yanming Zhou
Pages: 383-393
Published online: 17 Jan 2018
AbstractforPrognostic role of HSF1 overexpression in solid tumors: a pooled analysis of 3,159 patients | Full Text | References | PDF (1 MB)
  • 64 Views
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Open Access
Article
Progranulin modulates cholangiocarcinoma cell proliferation, apoptosis, and motility via the PI3K/pAkt pathway
Minerva Daya, Watcharin Loilome, Anchalee Techasen, Malinee Thanee, Prakasit Sa-Ngiamwibool, Attapol Titapun, Puangrat Yongvanit & Nisana Namwat
Pages: 395-408
Published online: 18 Jan 2018
AbstractforProgranulin modulates cholangiocarcinoma cell proliferation, apoptosis, and motility via the PI3K/pAkt pathway | Full Text | References | PDF (3 MB)
  • 121 Views
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Open Access
Article
Neoadjuvant chemoradiotherapy followed by surgery in patients with unresectable locally advanced colon cancer: a prospective observational study
Hui Chang, Xin Yu, Wei-wei Xiao, Qiao-xuan Wang, Wen-hao Zhou, Zhi-fan Zeng, Pei-rong Ding, Li-ren Li & Yuan-hong Gao
Pages: 409-418
Published online: 17 Jan 2018
AbstractforNeoadjuvant chemoradiotherapy followed by surgery in patients with unresectable locally advanced colon cancer: a prospective observational study | Full Text | References | PDF (931.4 KB)
  • 84 Views
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Open Access
Article
Biosimilar filgrastim vs filgrastim: a multicenter nationwide observational bioequivalence study in patients with chemotherapy-induced neutropenia
Alper Sevinç, Metin Özkan, Ahmet Özet, Faysal Dane, Berna Öksüzoğlu, Abdurrahman Işıkdoğan, Feyyaz Özdemir, Doğan Uncu, Mahmut Gümüş, Türkkan Evrensel, Arzu Yaren, Oğuz Kara & Salim Başol Tekin
Pages: 419-426
Published online: 14 Nov 2022
AbstractforBiosimilar filgrastim vs filgrastim: a multicenter nationwide observational bioequivalence study in patients with chemotherapy-induced neutropenia | Full Text | References | PDF (378.4 KB)
  • 71 Views
  • 1 CrossRef citations
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Open Access
Article
Long noncoding RNA H19 promotes transforming growth factor-β-induced epithelial–mesenchymal transition by acting as a competing endogenous RNA of miR-370-3p in ovarian cancer cells
Jing Li, YingYing Huang, XiaoJun Deng, ManLing Luo, XueFei Wang, HaiYan Hu, CiDi Liu & Mei Zhong
Pages: 427-440
Published online: 18 Jan 2018
AbstractforLong noncoding RNA H19 promotes transforming growth factor-β-induced epithelial–mesenchymal transition by acting as a competing endogenous RNA of miR-370-3p in ovarian cancer cells | Full Text | References | PDF (7.1 MB)
  • 84 Views
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Open Access
Article
Overexpression of LBH is associated with poor prognosis in human hepatocellular carcinoma
Jiewei Chen, Chuqiang Huang, Keming Chen, Shuman Li, Xinke Zhang, Jun Cheng, Muyan Cai & Yongbo Xiao
Pages: 441-448
Published online: 19 Jan 2018
AbstractforOverexpression of LBH is associated with poor prognosis in human hepatocellular carcinoma | Full Text | References | PDF (2.9 MB)
  • 74 Views
  • 11 CrossRef citations
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Open Access
Article
Association of clinicopathologic characteristics and outcomes with EZH2 expression in patients with breast cancer in East Azerbaijan, Iran
Farnaz Boostani, Roya Dolatkhah, Ashraf Fakhrjou, Faris Farassati & Zohreh Sanaat
Pages: 449-457
Published online: 19 Jan 2018
AbstractforAssociation of clinicopathologic characteristics and outcomes with EZH2 expression in patients with breast cancer in East Azerbaijan, Iran | Full Text | References | PDF (2.3 MB)
  • 65 Views
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Open Access

Case Report

Case Report
Apatinib-treated advanced medullary thyroid carcinoma: a case report
Kan Chen, Yun Gao, Fei Shi, Guangqiang Cao & Jiandong Bao
Pages: 459-463
Published online: 19 Jan 2018
AbstractforApatinib-treated advanced medullary thyroid carcinoma: a case report | Full Text | References | PDF (859.3 KB)
  • 48 Views
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Open Access

Review

Review Article
Subsequent anti-VEGF therapy after first-line anti-EGFR therapy improved overall survival of patients with metastatic colorectal cancer
Tianzhu Qiu, Wensen Chen, Ping Li, Jing Sun, Yanhong Gu & Xiaofeng Chen
Pages: 465-471
Published online: 22 Jan 2018
AbstractforSubsequent anti-VEGF therapy after first-line anti-EGFR therapy improved overall survival of patients with metastatic colorectal cancer | Full Text | References | PDF (422 KB)
  • 59 Views
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Open Access

Original Research

Article
Homeobox C10 knockdown suppresses cell proliferation and promotes cell apoptosis in osteosarcoma cells through regulating caspase 3
Xiankuan Xie, Yuxiang Xiao & Xin Huang
Pages: 473-482
Published online: 22 Jan 2018
AbstractforHomeobox C10 knockdown suppresses cell proliferation and promotes cell apoptosis in osteosarcoma cells through regulating caspase 3 | Full Text | References | PDF (1.7 MB)
  • 64 Views
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Open Access

Case Report

Case Report
Synovial sarcoma of the maxillary sinus: an extremely rare case with excellent response to chemotherapy
Shin Saito, Hiroyuki Ozawa, Yuuichi Ikari, Nana Nakahara, Fumihiro Ito, Mariko Sekimizu, Junichi Fukada, Kaori Kameyama & Kaoru Ogawa
Pages: 483-488
Published online: 23 Jan 2018
AbstractforSynovial sarcoma of the maxillary sinus: an extremely rare case with excellent response to chemotherapy | Full Text | References | PDF (3.5 MB)
  • 78 Views
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Open Access

Original Research

Article
ROS-dependent Bax/Bcl2 and caspase 3 pathway-mediated apoptosis induced by zineb in human keratinocyte cells
Daoud Ali, Abhilasha Tripathi, Hussain Al Ali, Yadvendra Shahi, Kamlesh K Mishra, Saud Alarifi, Abdullah A Alkahtane & Salem Manohardas
Pages: 489-497
Published online: 23 Jan 2018
AbstractforROS-dependent Bax/Bcl2 and caspase 3 pathway-mediated apoptosis induced by zineb in human keratinocyte cells | Full Text | References | PDF (1.4 MB)
  • 194 Views
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Open Access
Article
Prognostic role of neutrophil–lymphocyte ratio in multiple myeloma: a dose–response meta-analysis
Shidai Mu, Lisha Ai, Fengjuan Fan, Chunyan Sun & Yu Hu
Pages: 499-507
Published online: 23 Jan 2018
AbstractforPrognostic role of neutrophil–lymphocyte ratio in multiple myeloma: a dose–response meta-analysis | Full Text | References | PDF (1.1 MB)
  • 93 Views
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Open Access
Article
The prognostic role of Gas6/Axl axis in solid malignancies: a meta-analysis and literature review
Sheng Zhang, Xiang Shang Xu, Jie Xi Yang, Jian Hui Guo, Teng Fei Chao & YiXin Tong
Pages: 509-519
Published online: 23 Jan 2018
AbstractforThe prognostic role of Gas6/Axl axis in solid malignancies: a meta-analysis and literature review | Full Text | References | PDF (1.3 MB)
  • 90 Views
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Open Access
Article
The role of bevacizumab in targeted vascular endothelial growth factor therapy for epithelial ovarian cancer: an updated systematic review and meta-analysis
Guanyu Ruan, Lixiang Ye, Guifen Liu, Jian An, Jalid Sehouli & Pengming Sun
Pages: 521-528
Published online: 23 Jan 2018
AbstractforThe role of bevacizumab in targeted vascular endothelial growth factor therapy for epithelial ovarian cancer: an updated systematic review and meta-analysis | Full Text | References | PDF (974.3 KB)
  • 114 Views
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Open Access

Review

Review Article
Clinical efficacy and safety of afatinib in the treatment of non-small-cell lung cancer in Chinese patients
Lei-Yun Wang, Jia-Jia Cui, Ao-Xiang Guo & Ji-Ye Yin
Pages: 529-538
Published online: 24 Jan 2018
AbstractforClinical efficacy and safety of afatinib in the treatment of non-small-cell lung cancer in Chinese patients | Full Text | References | PDF (3.6 MB)
  • 66 Views
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Open Access

Original Research

Article
Nomogram for predicting survival in patients with pancreatic cancer
Wei Song, Dong-Liu Miao & Lei Chen
Pages: 539-545
Published online: 24 Jan 2018
AbstractforNomogram for predicting survival in patients with pancreatic cancer | Full Text | References | PDF (786.1 KB)
  • 114 Views
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Open Access
Article
Quantification of heart, pericardium, and left ventricular myocardium movements during the cardiac cycle for thoracic tumor radiotherapy
Ying Tong, Yong Yin, Jie Lu, Tonghai Liu, Jinhu Chen, Pinjing Cheng & Guanzhong Gong
Pages: 547-554
Published online: 24 Jan 2018
AbstractforQuantification of heart, pericardium, and left ventricular myocardium movements during the cardiac cycle for thoracic tumor radiotherapy | Full Text | References | PDF (1 MB)
  • 68 Views
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Open Access
Article
Clinical manifestations of pulmonary mucosa-associated lymphoid tissue lymphoma: single-center experience with 18 patients
Shasha Zhao, Lin Zhang, Zhenyang Gu, Chengying Zhu, Shu Fang, Nan Yang, Feiyan Wang, Lixun Guan, Lan Luo & Chunji Gao
Pages: 555-561
Published online: 24 Jan 2018
AbstractforClinical manifestations of pulmonary mucosa-associated lymphoid tissue lymphoma: single-center experience with 18 patients | Full Text | References | PDF (3.2 MB)
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Article
A non-synonymous polymorphism in NBS1 is associated with progression from chronic hepatitis B virus infection to hepatocellular carcinoma in a Chinese population
Ya’nan Zhen, Ruixue Xiao, Xing Chen, Changjin Yuan, Yanlai Sun & Jie Li
Pages: 563-569
Published online: 26 Jan 2018
AbstractforA non-synonymous polymorphism in NBS1 is associated with progression from chronic hepatitis B virus infection to hepatocellular carcinoma in a Chinese population | Full Text | References | PDF (317.8 KB)
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Article
miR-106b-5p promotes stem cell-like properties of hepatocellular carcinoma cells by targeting PTEN via PI3K/Akt pathway
Dong-Min Shi, Xin-Yu Bian, Cheng-Dong Qin & Wei-Zhong Wu
Pages: 571-585
Published online: 26 Jan 2018
AbstractformiR-106b-5p promotes stem cell-like properties of hepatocellular carcinoma cells by targeting PTEN via PI3K/Akt pathway | Full Text | References | PDF (9.6 MB)
  • 114 Views
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Article
Application of serum microRNA-9-5p, 21-5p, and 223-3p combined with tumor markers in the diagnosis of non-small-cell lung cancer in Yunnan in southwestern China
Yanlong Yang, Kai Chen, Yongchun Zhou, Zaoxiu Hu, Shuai Chen & Yunchao Huang
Pages: 587-597
Published online: 30 Jan 2018
AbstractforApplication of serum microRNA-9-5p, 21-5p, and 223-3p combined with tumor markers in the diagnosis of non-small-cell lung cancer in Yunnan in southwestern China | Full Text | References | PDF (2.5 MB)
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Article
ALDH1A2 suppresses epithelial ovarian cancer cell proliferation and migration by downregulating STAT3
Yichen Wang, Feng Shao & Lu Chen
Pages: 599-608
Published online: 31 Jan 2018
AbstractforALDH1A2 suppresses epithelial ovarian cancer cell proliferation and migration by downregulating STAT3 | Full Text | References | PDF (7 MB)
  • 99 Views
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Article
Identification of genomic expression differences between right-sided and left-sided colon cancer based on bioinformatics analysis
Qiliang Peng, Kaisu Lin, Tao Chang, Li Zou, Pengfei Xing, Yuntian Shen & Yaqun Zhu
Pages: 609-618
Published online: 31 Jan 2018
AbstractforIdentification of genomic expression differences between right-sided and left-sided colon cancer based on bioinformatics analysis | Full Text | References | PDF (2.5 MB)
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Article
The application of a three-dimensional visualized seed planning and navigation system in 125I seed implantation for pancreatic cancer
Yanyan Hu, Erpeng Qi, Fangyi Liu, Yuhan Lu, Shuilian Tan, Ya Sun, Zhiyu Han, Ping Liang & Xiaoling Yu
Pages: 619-627
Published online: 31 Jan 2018
AbstractforThe application of a three-dimensional visualized seed planning and navigation system in 125I seed implantation for pancreatic cancer | Full Text | References | PDF (1.5 MB)
  • 56 Views
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Article
The lncRNA PCAT1 is correlated with poor prognosis and promotes cell proliferation, invasion, migration and EMT in osteosarcoma
Xuedong Zhang, Yakui Zhang, Yong Mao & Xinlong Ma
Pages: 629-638
Published online: 14 Nov 2022
AbstractforThe lncRNA PCAT1 is correlated with poor prognosis and promotes cell proliferation, invasion, migration and EMT in osteosarcoma | Full Text | References | PDF (1.2 MB)
  • 75 Views
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Article
LincRNA-ROR promotes metastasis and invasion of esophageal squamous cell carcinoma by regulating miR-145/FSCN1
Muhe Shang, Xianghu Wang, Ying Zhang, Zhikui Gao, Tian Wang & Ran Liu
Pages: 639-649
Published online: 31 Jan 2018
AbstractforLincRNA-ROR promotes metastasis and invasion of esophageal squamous cell carcinoma by regulating miR-145/FSCN1 | Full Text | References | PDF (1.3 MB)
  • 71 Views
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Article
Role of MLH1 methylation in esophageal cancer carcinogenesis and its clinical significance
Jinyun Li, Dong Ye, Lei Wang, Yingying Peng, Qun Li, Hongxia Deng & Chongchang Zhou
Pages: 651-663
Published online: 01 Feb 2018
AbstractforRole of MLH1 methylation in esophageal cancer carcinogenesis and its clinical significance | Full Text | References | PDF (1.7 MB)
  • 78 Views
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Article
Associations between ABCG2 gene polymorphisms and gefitinib toxicity in non-small cell lung cancer: a meta-analysis
Lina Tang, Chunling Zhang, Hairong He, Zhenyu Pan, Di Fan, Yinli He, Haisheng You & Yuanjie Li
Pages: 665-675
Published online: 01 Feb 2018
AbstractforAssociations between ABCG2 gene polymorphisms and gefitinib toxicity in non-small cell lung cancer: a meta-analysis | Full Text | References | PDF (963.9 KB)
  • 59 Views
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Article
Effects of core needle biopsy and subsequent neoadjuvant chemotherapy on molecular alterations and outcome in breast cancer
Lingmin Xie, Xiaolei Li, Qinchuan Wang, Jichun Zhou, Jun Shen, Lixi Luo, Yi Lu & Linbo Wang
Pages: 677-685
Published online: 14 Nov 2022
AbstractforEffects of core needle biopsy and subsequent neoadjuvant chemotherapy on molecular alterations and outcome in breast cancer | Full Text | References | PDF (1.6 MB)
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Corrigendum

Correction
PUMA mediates the anti-cancer effect of osimertinib in colon cancer cells [Corrigendum]
Page: 687
Published online: 02 Feb 2018
CitationforPUMA mediates the anti-cancer effect of osimertinib in colon cancer cells [Corrigendum] | Full Text | PDF (141.3 KB)
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Original Research

Article
Overexpression of Zwint predicts poor prognosis and promotes the proliferation of hepatocellular carcinoma by regulating cell-cycle-related proteins
Hanning Ying, Zhiyao Xu, Mingming Chen, Senjun Zhou, Xiao Liang & Xiujun Cai
Pages: 689-702
Published online: 02 Feb 2018
AbstractforOverexpression of Zwint predicts poor prognosis and promotes the proliferation of hepatocellular carcinoma by regulating cell-cycle-related proteins | Full Text | References | PDF (9.9 MB)
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Article
Association between IL-17A G197A polymorphism and gastric cancer risk: an updated meta-analysis based on 6,624 cases and 7,631 controls
Lixia Hu, Fanliang Kong & Yueyin Pan
Pages: 703-710
Published online: 05 Feb 2018
AbstractforAssociation between IL-17A G197A polymorphism and gastric cancer risk: an updated meta-analysis based on 6,624 cases and 7,631 controls | Full Text | References | PDF (2.1 MB)
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Article
Use of phosphodiesterase type 5 inhibitors and risk of melanoma: a meta-analysis of observational studies
Xinming Han, Yan Han, Yongsheng Zheng, Qiang Sun, Tao Ma, Li Dai, Junyi Zhang & Lianji Xu
Pages: 711-720
Published online: 05 Feb 2018
AbstractforUse of phosphodiesterase type 5 inhibitors and risk of melanoma: a meta-analysis of observational studies | Full Text | References | PDF (892 KB)
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Article
Efficacy and safety of COX-2 inhibitors for advanced non-small-cell lung cancer with chemotherapy: a meta-analysis
Ping Dai, Jing Li, Xiao-Ping Ma, Jian Huang, Juan-Juan Meng & Ping Gong
Pages: 721-730
Published online: 14 Nov 2022
AbstractforEfficacy and safety of COX-2 inhibitors for advanced non-small-cell lung cancer with chemotherapy: a meta-analysis | Full Text | References | PDF (1.5 MB)
  • 46 Views
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Article
Prognostic significance of epidermal growth factor receptor expression in glioma patients
Junhong Li, Ruofei Liang, Chen Song, Yufan Xiang & Yanhui Liu
Pages: 731-742
Published online: 07 Feb 2018
AbstractforPrognostic significance of epidermal growth factor receptor expression in glioma patients | Full Text | References | PDF (1.6 MB)
  • 113 Views
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Article
Expression of Nemo-like kinase in cervical squamous cell carcinoma: a clinicopathological study
Weina Yang, Lina Gu, Chang Yang & Tianbo Liu
Pages: 743-749
Published online: 08 Feb 2018
AbstractforExpression of Nemo-like kinase in cervical squamous cell carcinoma: a clinicopathological study | Full Text | References | PDF (1.1 MB)
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Case Report

Case Report
Molecular features of giant-cell carcinoma of the lung: a case report and literature review
Xin Li, Zihe Zhang, Jinghao Liu, Dan Wang, Sen Wei & Jun Chen
Pages: 751-756
Published online: 09 Feb 2018
AbstractforMolecular features of giant-cell carcinoma of the lung: a case report and literature review | Full Text | References | PDF (772.7 KB)
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Original Research

Article
Raptor mediates the antiproliferation of cardamonin by mTORC1 inhibition in SKOV3 cells
Daohua Shi, Yanting Zhu, Peiguang Niu, Jintuo Zhou & Huajiao Chen
Pages: 757-767
Published online: 09 Feb 2018
AbstractforRaptor mediates the antiproliferation of cardamonin by mTORC1 inhibition in SKOV3 cells | Full Text | References | PDF (2.8 MB)
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Article
RETRACTED ARTICLE: Antitumor effect of triptolide in T-cell lymphoblastic lymphoma by inhibiting cell viability, invasion, and epithelial–mesenchymal transition via regulating the PI3K/AKT/mTOR pathway
Yan Huang, Sun Wu, Yuan Zhang, Lihua Wang & Yan Guo
Pages: 769-779
Published online: 12 Feb 2018
AbstractforRETRACTED ARTICLE: Antitumor effect of triptolide in T-cell lymphoblastic lymphoma by inhibiting cell viability, invasion, and epithelial–mesenchymal transition via regulating the PI3K/AKT/mTOR pathway | PDF (11.2 MB)
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Article
ISL1 is upregulated in breast cancer and promotes cell proliferation, invasion, and angiogenesis
Lin Li, Fuwen Sun, Xiaoyan Chen & Minghui Zhang
Pages: 781-789
Published online: 14 Feb 2018
AbstractforISL1 is upregulated in breast cancer and promotes cell proliferation, invasion, and angiogenesis | Full Text | References | PDF (2.5 MB)
  • 61 Views
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Article
The association between HOTAIR polymorphisms and cancer susceptibility: an updated systemic review and meta-analysis
Ling Min, Xiyan Mu, An Tong, Yanping Qian, Chen Ling, Tao Yi & Xia Zhao
Pages: 791-800
Published online: 14 Feb 2018
AbstractforThe association between HOTAIR polymorphisms and cancer susceptibility: an updated systemic review and meta-analysis | Full Text | References | PDF (915.3 KB)
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Article
Clinical significance of quantitative HER2 gene amplification as related to its predictive value in breast cancer patients in neoadjuvant setting
Ziping Wu, Shuguang Xu, Liheng Zhou, Wenjin Yin, Yanpin Lin, Yueyao Du, Yaohui Wang, Yiwei Jiang, Kai Yin, Jie Zhang & Jinsong Lu
Pages: 801-808
Published online: 15 Feb 2018
AbstractforClinical significance of quantitative HER2 gene amplification as related to its predictive value in breast cancer patients in neoadjuvant setting | Full Text | References | PDF (1 MB)
  • 92 Views
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Article
Knockdown of KLK11 reverses oxaliplatin resistance by inhibiting proliferation and activating apoptosis via suppressing the PI3K/AKT signal pathway in colorectal cancer cell
Yiyi Zhang, Zongbin Xu, Yanwu Sun, Pan Chi & Xingrong Lu
Pages: 809-821
Published online: 16 Feb 2018
AbstractforKnockdown of KLK11 reverses oxaliplatin resistance by inhibiting proliferation and activating apoptosis via suppressing the PI3K/AKT signal pathway in colorectal cancer cell | Full Text | References | PDF (3.6 MB)
  • 102 Views
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Article
MiR-1180-5p regulates apoptosis of Wilms’ tumor by targeting p73
Xiuyun Jiang & Huaicheng Li
Pages: 823-831
Published online: 14 Nov 2022
AbstractforMiR-1180-5p regulates apoptosis of Wilms’ tumor by targeting p73 | Full Text | References | PDF (2.5 MB)
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Review

Review Article
Developments in the management of advanced soft-tissue sarcoma – olaratumab in context
Gianluca Moroncini, Elena Maccaroni, Ilaria Fiordoliva, Chiara Pellei, Armando Gabrielli & Rossana Berardi
Pages: 833-842
Published online: 16 Feb 2018
AbstractforDevelopments in the management of advanced soft-tissue sarcoma – olaratumab in context | Full Text | References | PDF (424.6 KB)
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Original Research

Article
Interleukin-33 enhanced the migration and invasiveness of human lung cancer cells
Zhiping Yang, Xin Gao, Jingyu Wang, Longsheng Xu, Ying Zheng & Yufen Xu
Pages: 843-849
Published online: 16 Feb 2018
AbstractforInterleukin-33 enhanced the migration and invasiveness of human lung cancer cells | Full Text | References | PDF (2.4 MB)
  • 70 Views
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Article
Effects of four single nucleotide polymorphisms of EZH2 on cancer risk: a systematic review and meta-analysis
Zhixin Ling, Zonghao You, Ling Hu, Lei Zhang, Yiduo Wang, Minhao Zhang, Guangyuan Zhang, Shuqiu Chen, Bin Xu & Ming Chen
Pages: 851-865
Published online: 16 Feb 2018
AbstractforEffects of four single nucleotide polymorphisms of EZH2 on cancer risk: a systematic review and meta-analysis | Full Text | References | PDF (2 MB)
  • 63 Views
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Article
Klotho ameliorates sepsis-induced acute kidney injury but is irrelevant to autophagy
Xinxin Chen, Huan Tong, Yu Chen, Chaosheng Chen, Jingjing Ye, Qingfei Mo, Guangju Zhao, Guangliang Hong, Chenfei Zheng & Zhongqiu Lu
Pages: 867-881
Published online: 19 Feb 2018
AbstractforKlotho ameliorates sepsis-induced acute kidney injury but is irrelevant to autophagy | Full Text | References | PDF (10.4 MB)
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Case Series

Successful treatment of metastatic colorectal cancer with apatinib: report of two cases and literature review
Minghong Bi, Jingru Yang, Yaping Wang, Haoran Zhang, Zhenyuan Gao, Hairong Zhou & Mohan Shi
Pages: 883-890
Published online: 19 Feb 2018
AbstractforSuccessful treatment of metastatic colorectal cancer with apatinib: report of two cases and literature review | Full Text | References | PDF (847.9 KB)
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Original Research

Article
CDCA5 regulates proliferation in hepatocellular carcinoma and has potential as a negative prognostic marker
Zhiqing Shen, Xueping Yu, Yijuan Zheng, Xueping Lai, Julan Li, Yuxiang Hong, Huatang Zhang, Chunlin Chen, Zhijun Su & Ruyi Guo
Pages: 891-901
Published online: 14 Nov 2022
AbstractforCDCA5 regulates proliferation in hepatocellular carcinoma and has potential as a negative prognostic marker | Full Text | References | PDF (5.3 MB)
  • 67 Views
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Article
Postoperative hepatic arterial infusion chemotherapy improved survival of pancreatic cancer after radical pancreatectomy: a retrospective study
Yongchun Wang, Yongqiang Xu, Yinyuan Zheng, Ying Bao & Ping Wang
Pages: 903-907
Published online: 21 Feb 2018
AbstractforPostoperative hepatic arterial infusion chemotherapy improved survival of pancreatic cancer after radical pancreatectomy: a retrospective study | Full Text | References | PDF (555.7 KB)
  • 67 Views
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Article
Low levels of tumor suppressor candidate 3 predict poor prognosis of patients with hepatocellular carcinoma
Xu-Ren Sheng, Song-Ge Xing, Run-Dong Wang, Kang Chen & Wei-Dong Jia
Pages: 909-917
Published online: 21 Feb 2018
AbstractforLow levels of tumor suppressor candidate 3 predict poor prognosis of patients with hepatocellular carcinoma | Full Text | References | PDF (3.3 MB)
  • 56 Views
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Article
The investigation for potential modifier genes in patients with neurofibromatosis type 1 based on next-generation sequencing
Fan Yang, Song Xu, Renwang Liu, Tao Shi, Xiongfei Li, Xuebing Li, Gang Chen, Hongyu Liu, Qinghua Zhou & Jun Chen
Pages: 919-932
Published online: 14 Nov 2022
AbstractforThe investigation for potential modifier genes in patients with neurofibromatosis type 1 based on next-generation sequencing | Full Text | References | PDF (10.2 MB)
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Article
Characterization of luteinizing hormone-releasing hormone receptor type I (LH-RH-I) as a potential molecular target in OCM-1 and OCM-3 human uveal melanoma cell lines
Eva Sipos, Nikoletta Dobos, David Rozsa, Klara Fodor, Gabor Olah, Zsuzsanna Szabo, Lorant Szekvolgyi, Andrew V Schally & Gabor Halmos
Pages: 933-941
Published online: 22 Feb 2018
AbstractforCharacterization of luteinizing hormone-releasing hormone receptor type I (LH-RH-I) as a potential molecular target in OCM-1 and OCM-3 human uveal melanoma cell lines | Full Text | References | PDF (757.8 KB)
  • 66 Views
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Article
Role of ubenimex as an anticancer drug and its synergistic effect with Akt inhibitor in human A375 and A2058 cells
Xiaoqing Wang, Yang Liu, Rongde Wu, Feng Guo, Lijuan Zhang, Mingyu Cui, Xiangyu Wu, Yongfei Zhang & Wei Liu
Pages: 943-953
Published online: 22 Feb 2018
AbstractforRole of ubenimex as an anticancer drug and its synergistic effect with Akt inhibitor in human A375 and A2058 cells | Full Text | References | PDF (7.4 MB)
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Review

Review Article
Prognostic utility of baseline neutrophil-to-lymphocyte ratio in patients receiving immune checkpoint inhibitors: a review and meta-analysis
Danielle Benedict Sacdalan, Josephine Anne Lucero & Dennis Lee Sacdalan
Pages: 955-965
Published online: 23 Feb 2018
AbstractforPrognostic utility of baseline neutrophil-to-lymphocyte ratio in patients receiving immune checkpoint inhibitors: a review and meta-analysis | Full Text | References | PDF (904.4 KB)
  • 262 Views
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Original Research

Article
Prognostic significance of mucinous component in gastric adenocarcinoma after radical D2 gastrectomy
Lei Cai, Yan Li, Xue-wen Yang, Xiao Lian, Man Guo, Shu-ao Xiao, Wen-bin Wang & Hong-wei Zhang
Pages: 967-973
Published online: 23 Feb 2018
AbstractforPrognostic significance of mucinous component in gastric adenocarcinoma after radical D2 gastrectomy | Full Text | References | PDF (1.1 MB)
  • 62 Views
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Article
Role of palliative resection of the primary pancreatic neuroendocrine tumor in patients with unresectable metastatic liver disease: a systematic review and meta-analysis
Bo Zhou, Canyang Zhan, Yuan Ding, Sheng Yan & Shusen Zheng
Pages: 975-982
Published online: 23 Feb 2018
AbstractforRole of palliative resection of the primary pancreatic neuroendocrine tumor in patients with unresectable metastatic liver disease: a systematic review and meta-analysis | Full Text | References | PDF (746.3 KB)
  • 91 Views
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Article
RETRACTED ARTICLE: Kanglaite reverses multidrug resistance of HCC by inducing apoptosis and cell cycle arrest via PI3K/AKT pathway
Chendong Yang, Aihua Hou, Chunfeng Yu, Lingling Dai, Wen Wang, Kangle Zhang, Hongmin Shao, Jinghua Ma & Wenjuan Xu
Pages: 983-996
Published online: 26 Feb 2018
AbstractforRETRACTED ARTICLE: Kanglaite reverses multidrug resistance of HCC by inducing apoptosis and cell cycle arrest via PI3K/AKT pathway | PDF (3.7 MB)
  • 87 Views
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Review

Review Article
Prognostic significance of Epstein–Barr virus DNA in NK/T-cell lymphoma: a meta-analysis
Qian Fei, Xiao-Kang Tian, Jing Wu, Hong-Ming Zhu, Yan Wang, Fan-Yu Peng, Wen-Jun Zhang, Li Yin & Xia He
Pages: 997-1004
Published online: 26 Feb 2018
AbstractforPrognostic significance of Epstein–Barr virus DNA in NK/T-cell lymphoma: a meta-analysis | Full Text | References | PDF (779.5 KB)
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Original Research

Article
How many ELNs are optimal for breast cancer patients with more than three PLNs who underwent MRM? A large population-based study
Xiaohui Wang, Changbin Ji, Huiying Chi & Haiyong Wang
Pages: 1005-1011
Published online: 26 Feb 2018
AbstractforHow many ELNs are optimal for breast cancer patients with more than three PLNs who underwent MRM? A large population-based study | Full Text | References | PDF (866.7 KB)
  • 48 Views
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Article
Prognostic value of circulating tumor cells detected with the CellSearch System in patients with gastric cancer: evidence from a meta-analysis
Chaogang Yang, Kun Zou, Zewei Yuan, Tangxi Guo & Bin Xiong
Pages: 1013-1023
Published online: 26 Feb 2018
AbstractforPrognostic value of circulating tumor cells detected with the CellSearch System in patients with gastric cancer: evidence from a meta-analysis | Full Text | References | PDF (1.1 MB)
  • 80 Views
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Article
Reversine, a substituted purine, exerts an inhibitive effect on human renal carcinoma cells via induction of cell apoptosis and polyploidy
Li Cheng, Hao Wang, Kecun Guo, Zicheng Wang, Zhongyuan Zhang, Cheng Shen, Liang Chen & Jian Lin
Pages: 1025-1035
Published online: 26 Feb 2018
AbstractforReversine, a substituted purine, exerts an inhibitive effect on human renal carcinoma cells via induction of cell apoptosis and polyploidy | Full Text | References | PDF (20.1 MB)
  • 65 Views
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Article
Clinicopathologic characteristics and prognosis of proximal and distal gastric cancer
Xuefeng Yu, Fulan Hu, Chunfeng Li, Qiang Yao, Hongfeng Zhang & Yingwei Xue
Pages: 1037-1044
Published online: 27 Feb 2018
AbstractforClinicopathologic characteristics and prognosis of proximal and distal gastric cancer | Full Text | References | PDF (553.2 KB)
  • 101 Views
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Article
CXCR3 is a prognostic marker and a potential target for patients with solid tumors: a meta-analysis
Yang Zhang, Linjuan Xu & Minggang Peng
Pages: 1045-1054
Published online: 27 Feb 2018
AbstractforCXCR3 is a prognostic marker and a potential target for patients with solid tumors: a meta-analysis | Full Text | References | PDF (839.4 KB)
  • 63 Views
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Article
Genetic association between HER2 and ESR2 polymorphisms and ovarian cancer: a meta-analysis
Liang Tang, Jianming Li, Meihua Bao, Ju Xiang, Yiwei Chen & Yan Wang
Pages: 1055-1066
Published online: 14 Nov 2022
AbstractforGenetic association between HER2 and ESR2 polymorphisms and ovarian cancer: a meta-analysis | Full Text | References | PDF (1.2 MB)
  • 77 Views
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Article
Forkhead box K2 inhibits the proliferation, migration, and invasion of human glioma cells and predicts a favorable prognosis
Bo Wang, XueBin Zhang, Wei Wang, ZhiZhong Zhu, Fan Tang, Dong Wang, Xi Liu, Hao Zhuang & XiaoLing Yan
Pages: 1067-1075
Published online: 27 Feb 2018
AbstractforForkhead box K2 inhibits the proliferation, migration, and invasion of human glioma cells and predicts a favorable prognosis | Full Text | References | PDF (2.8 MB)
  • 71 Views
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Article
Association of doublecortin-like kinase 1 with tumor aggressiveness and poor biochemical recurrence-free survival in prostate cancer
Donggen Jiang, Chutian Xiao, Tuzeng Xian, Liantao Wang, Yunhua Mao, Junfu Zhang & Jun Pang
Pages: 1077-1086
Published online: 28 Feb 2018
AbstractforAssociation of doublecortin-like kinase 1 with tumor aggressiveness and poor biochemical recurrence-free survival in prostate cancer | Full Text | References | PDF (1,013.4 KB)
  • 73 Views
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Article
Comparison between multi-slice spiral CT and magnetic resonance imaging in the diagnosis of peritoneal metastasis in primary ovarian carcinoma
Hong-Lei Guo, Ling He, Yan-Cui Zhu, Kun Wu & Feng Yuan
Pages: 1087-1094
Published online: 14 Nov 2022
AbstractforComparison between multi-slice spiral CT and magnetic resonance imaging in the diagnosis of peritoneal metastasis in primary ovarian carcinoma | Full Text | References | PDF (3.3 MB)
  • 71 Views
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Article
TSPAN12 is overexpressed in NSCLC via p53 inhibition and promotes NSCLC cell growth in vitro and in vivo
Zhongwu Hu, Daorong Hou, Xiaowei Wang, Zhenbing You & Xiufeng Cao
Pages: 1095-1103
Published online: 01 Mar 2018
AbstractforTSPAN12 is overexpressed in NSCLC via p53 inhibition and promotes NSCLC cell growth in vitro and in vivo | Full Text | References | PDF (1.3 MB)
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Article
The efficacy and safety of alectinib in the treatment of ALK+ NSCLC: a systematic review and meta-analysis
Junsheng Fan, Zengfei Xia, Xiaoli Zhang, Yuqing Chen, Ruolan Qian, Sihan Liu, Danming You, Jian Zhang & Peng Luo
Pages: 1105-1115
Published online: 14 Nov 2022
AbstractforThe efficacy and safety of alectinib in the treatment of ALK+ NSCLC: a systematic review and meta-analysis | Full Text | References | PDF (993.3 KB)
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Case Report

Case Report
Response to crizotinib in a non-small-cell lung cancer patient harboring an EML4-ALK fusion with an atypical LTBP1 insertion
Cristina Aguado, Maria-de-los-Llanos Gil, Zaira Yeste, Ana Giménez-Capitán, Cristina Teixidó, Niki Karachaliou, Santiago Viteri, Rafael Rosell & Miguel A Molina-Vila
Pages: 1117-1120
Published online: 01 Mar 2018
AbstractforResponse to crizotinib in a non-small-cell lung cancer patient harboring an EML4-ALK fusion with an atypical LTBP1 insertion | Full Text | References | PDF (1.1 MB)
  • 68 Views
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Review

Review Article
rs11614913 polymorphism in miRNA-196a2 and cancer risk: an updated meta-analysis
Yuhan Liu, Anbang He, Baoer Liu, Yucheng Zhong, Xinhui Liao, Jiangeng Yang, Jieqing Chen, Jianting Wu & Hongbing Mei
Pages: 1121-1139
Published online: 01 Mar 2018
Abstractforrs11614913 polymorphism in miRNA-196a2 and cancer risk: an updated meta-analysis | Full Text | References | PDF (3 MB)
  • 190 Views
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Original Research

Article
Effects of propofol-based total intravenous anesthesia on gastric cancer: a retrospective study
Xiaoyu Zheng, Yu Wang, Linlin Dong, Su Zhao, Liping Wang, Hong Chen, Yang Xu & Guonian Wang
Pages: 1141-1148
Published online: 01 Mar 2018
AbstractforEffects of propofol-based total intravenous anesthesia on gastric cancer: a retrospective study | Full Text | References | PDF (777.1 KB)
  • 187 Views
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Article
Cisplatin concurrent chemoradiotherapy vs adjuvant radiation in stage IB/IIA cervical cancer with intermediate risk factors, treated with radical surgery: a retrospective study
Hai-Yan Sun, Qiu Tang, Jian-Hong Chen, Xiao-Juan Lv, Ye-Qiang Tu & Ding-Ding Yan
Pages: 1149-1155
Published online: 06 Mar 2018
AbstractforCisplatin concurrent chemoradiotherapy vs adjuvant radiation in stage IB/IIA cervical cancer with intermediate risk factors, treated with radical surgery: a retrospective study | Full Text | References | PDF (501.4 KB)
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Article
SIRT1 overexpression protects non-small cell lung cancer cells against osteopontin-induced epithelial-mesenchymal transition by suppressing NF-κB signaling
Xuejiao Li, Zhongxiu Jiang, Xiangmin Li & Xiaoye Zhang
Pages: 1157-1171
Published online: 02 Mar 2018
AbstractforSIRT1 overexpression protects non-small cell lung cancer cells against osteopontin-induced epithelial-mesenchymal transition by suppressing NF-κB signaling | Full Text | References | PDF (7.5 MB)
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Article
Hepatitis C virus core impacts expression of miR122 and miR204 involved in carcinogenic progression via regulation of TGFBRAP1 and HOTTIP expression
Xiaoying Wang, Jiefu Peng, Jing Wang, Miao Li, Di Wu, Songyan Wu, Jipei Liao & Jun Dou
Pages: 1173-1182
Published online: 02 Mar 2018
AbstractforHepatitis C virus core impacts expression of miR122 and miR204 involved in carcinogenic progression via regulation of TGFBRAP1 and HOTTIP expression | Full Text | References | PDF (1.3 MB)
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Article
Evodiamine activates cellular apoptosis through suppressing PI3K/AKT and activating MAPK in glioma
Rong Wang, Danni Deng, Naiyuan Shao, Yuan Xu, Lian Xue, Ya Peng, Yatian Liu & Feng Zhi
Pages: 1183-1192
Published online: 02 Mar 2018
AbstractforEvodiamine activates cellular apoptosis through suppressing PI3K/AKT and activating MAPK in glioma | Full Text | References | PDF (7.7 MB)
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Article
Impact of diabetes mellitus on the risk and survival of nasopharyngeal carcinoma: a meta-analysis
Gang Guo, Moushun Fu, Shuxiang Wei & Ruiwan Chen
Pages: 1193-1201
Published online: 02 Mar 2018
AbstractforImpact of diabetes mellitus on the risk and survival of nasopharyngeal carcinoma: a meta-analysis | Full Text | References | PDF (754.2 KB)
  • 54 Views
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Article
Clinicopathological significance and prognostic role of p-STAT3 in patients with hepatocellular carcinoma
Chaojie Liang, Yingchen Xu, Hua Ge, Guangming Li & Jixiang Wu
Pages: 1203-1214
Published online: 05 Mar 2018
AbstractforClinicopathological significance and prognostic role of p-STAT3 in patients with hepatocellular carcinoma | Full Text | References | PDF (1.3 MB)
  • 69 Views
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Article
Leukemia-related protein 16 (LRP16) promotes tumor growth and metastasis in pancreatic cancer
Zheng Mo, Minggen Hu, Fei Yu, Lijuan Shao, Kexing Fan & Shunchang Jiao
Pages: 1215-1222
Published online: 14 Nov 2022
AbstractforLeukemia-related protein 16 (LRP16) promotes tumor growth and metastasis in pancreatic cancer | Full Text | References | PDF (3.5 MB)
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Article
A national, multicenter, non-interventional, observational study on treatment patterns in patients with metastatic renal cell carcinoma in Turkey – NOTES study
Şuayib Yalçın, Ramazan Yildiz, Faysal Dane, Aziz Karaoğlu, Berna Öksüzoğlu, Özgür Özyılkan, Alper Sevinç, Feyyaz Özdemir, Hande Turna, Rüçhan Uslu & Esat Ulay
Pages: 1223-1228
Published online: 05 Mar 2018
AbstractforA national, multicenter, non-interventional, observational study on treatment patterns in patients with metastatic renal cell carcinoma in Turkey – NOTES study | Full Text | References | PDF (539.7 KB)
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Review

Review Article
Clinical value of Xenopus kinesin-like protein 2 as a prognostic marker in patients with digestive system cancers: a systematic review and meta-analysis
Gang Wang, Qian Wang, Zhengyan Li, Chaoxu Liu & Xianli He
Pages: 1229-1243
Published online: 05 Mar 2018
AbstractforClinical value of Xenopus kinesin-like protein 2 as a prognostic marker in patients with digestive system cancers: a systematic review and meta-analysis | Full Text | References | PDF (1.6 MB)
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Original Research

Article
Icotinib hydrochloride enhances chemo- and radiosensitivity by inhibiting EGFR signaling and attenuating RAD51 expression and function in Hela S3 cells
Xuanxuan Wang, Yanjun Gu, Hai Liu, Liming Shi & Xiaonan Sun
Pages: 1245-1258
Published online: 05 Mar 2018
AbstractforIcotinib hydrochloride enhances chemo- and radiosensitivity by inhibiting EGFR signaling and attenuating RAD51 expression and function in Hela S3 cells | Full Text | References | PDF (7.6 MB)
  • 65 Views
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Article
Decreased expression of LKB1 predicts poor prognosis in pancreatic neuroendocrine tumor patients undergoing curative resection
Dezhi Li, Yu Zhou, Yanhui Liu, Ye Lin, Min Yu, Xin Lu, Bowen Huang, Zhonghai Sun, Zhixiang Jian & Baohua Hou
Pages: 1259-1265
Published online: 06 Mar 2018
AbstractforDecreased expression of LKB1 predicts poor prognosis in pancreatic neuroendocrine tumor patients undergoing curative resection | Full Text | References | PDF (2.7 MB)
  • 70 Views
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Article
Vascular endothelial growth factor suppresses dendritic cells function of human prostate cancer
Wen-kun Bai, Wei Zhang & Bing Hu
Pages: 1267-1274
Published online: 06 Mar 2018
AbstractforVascular endothelial growth factor suppresses dendritic cells function of human prostate cancer | Full Text | References | PDF (648.5 KB)
  • 56 Views
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Article
MicroRNA 302b-3p/302c-3p/302d-3p inhibits epithelial–mesenchymal transition and promotes apoptosis in human endometrial carcinoma cells
Yibing Li, Jianing Huo, Xin Pan, Cuicui Wang & Xiaoxin Ma
Pages: 1275-1284
Published online: 06 Mar 2018
AbstractforMicroRNA 302b-3p/302c-3p/302d-3p inhibits epithelial–mesenchymal transition and promotes apoptosis in human endometrial carcinoma cells | Full Text | References | PDF (8.3 MB)
  • 74 Views
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Article
Overexpression of c-kit(CD117), relevant with microvessel density, is an independent survival prognostic factor for patients with HBV-related hepatocellular carcinoma
Weiwei Yan, Zhenyu Zhu, Fei Pan, Ang Huang & Guang-hai Dai
Pages: 1285-1292
Published online: 07 Mar 2018
AbstractforOverexpression of c-kit(CD117), relevant with microvessel density, is an independent survival prognostic factor for patients with HBV-related hepatocellular carcinoma | Full Text | References | PDF (1.9 MB)
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Article
The clinicopathological and prognostic value of HSP27 in hepatocellular carcinoma: a systematic review and meta-analysis
Chaojie Liang, Yingchen Xu, Hua Ge, Guangming Li & Jixiang Wu
Pages: 1293-1303
Published online: 07 Mar 2018
AbstractforThe clinicopathological and prognostic value of HSP27 in hepatocellular carcinoma: a systematic review and meta-analysis | Full Text | References | PDF (1.4 MB)
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Article
Prognostic significance of preoperative IKBKE expression in esophageal squamous cell carcinoma
Wenjing Yang, Yan Qu, Bingxu Tan, Yibin Jia, Nana Wang, Peng Hu & Jianbo Wang
Pages: 1305-1314
Published online: 07 Mar 2018
AbstractforPrognostic significance of preoperative IKBKE expression in esophageal squamous cell carcinoma | Full Text | References | PDF (6.4 MB)
  • 53 Views
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Article
Clinicopathological characteristics and prognosis of adult ovarian granulosa cell tumor: a single-institution experience in China
Dan Wang, Yang Xiang, Ming Wu, Keng Shen, Jiaxin Yang, Huifang Huang & Tong Ren
Pages: 1315-1322
Published online: 07 Mar 2018
AbstractforClinicopathological characteristics and prognosis of adult ovarian granulosa cell tumor: a single-institution experience in China | Full Text | References | PDF (446.4 KB)
  • 68 Views
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Article
CREB promotes laryngeal cancer cell migration via MYCT1/NAT10 axis
Zhao-Xiong Zhang, Wan-Ni Zhang, Yuan-Yuan Sun, Yun-Hui Li, Zhen-Ming Xu & Wei-Neng Fu
Pages: 1323-1331
Published online: 08 Mar 2018
AbstractforCREB promotes laryngeal cancer cell migration via MYCT1/NAT10 axis | Full Text | References | PDF (2.9 MB)
  • 72 Views
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Article
SPP1 promotes ovarian cancer progression via Integrin β1/FAK/AKT signaling pathway
Biao Zeng, Min Zhou, Huan Wu & Zhengai Xiong
Pages: 1333-1343
Published online: 12 Mar 2018
AbstractforSPP1 promotes ovarian cancer progression via Integrin β1/FAK/AKT signaling pathway | Full Text | References | PDF (3.8 MB)
  • 279 Views
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Article
IL13Rα2 siRNA inhibited cell proliferation, induced cell apoptosis, and suppressed cell invasion in papillary thyroid carcinoma cells
Mingjun Gu
Pages: 1345-1352
Published online: 09 Mar 2018
AbstractforIL13Rα2 siRNA inhibited cell proliferation, induced cell apoptosis, and suppressed cell invasion in papillary thyroid carcinoma cells | Full Text | References | PDF (2.8 MB)
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Article
Clinicopathological features and prognosis in elderly gastric cancer patients: a retrospective cohort study
Guanghui Xu, Fan Feng, Shushang Liu, Fei Wang, Gaozan Zheng, Qiao Wang, Lei Cai, Man Guo, Xiao Lian & Hongwei Zhang
Pages: 1353-1362
Published online: 12 Mar 2018
AbstractforClinicopathological features and prognosis in elderly gastric cancer patients: a retrospective cohort study | Full Text | References | PDF (2.7 MB)
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Article
Evaluation of biologically active substances promoting the development of or protecting against endometrial cancer
Aneta Cymbaluk-Płoska, Anita Chudecka-Głaz, Anna Jagodzińska, Ewa Pius-Sadowska, Agnieszka Sompolska-Rzechuła, Bogusław Machaliński & Janusz Menkiszak
Pages: 1363-1372
Published online: 14 Nov 2022
AbstractforEvaluation of biologically active substances promoting the development of or protecting against endometrial cancer | Full Text | References | PDF (2.6 MB)
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Article
Reliability of using circulating tumor cells for detecting epidermal growth factor receptor mutation status in advanced non-small-cell lung cancer patients: a meta-analysis and systematic review
Fang Hu, Xiaowei Mao, Yujun Zhang, Xiaoxuan Zheng, Ping Gu, Huimin Wang & Xueyan Zhang
Pages: 1373-1384
Published online: 14 Mar 2018
AbstractforReliability of using circulating tumor cells for detecting epidermal growth factor receptor mutation status in advanced non-small-cell lung cancer patients: a meta-analysis and systematic review | Full Text | References | PDF (4.3 MB)
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Article
Rhein inhibits malignant phenotypes of human renal cell carcinoma by impacting on MAPK/NF-κB signaling pathways
Ya-Li Ma, Fang Chen & Jun Shi
Pages: 1385-1394
Published online: 14 Mar 2018
AbstractforRhein inhibits malignant phenotypes of human renal cell carcinoma by impacting on MAPK/NF-κB signaling pathways | Full Text | References | PDF (3.6 MB)
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Article
Fast hemostasis: a win–win strategy for ultrasound and microwave ablation
Jiabao Guo, Guo Tian, Qiyu Zhao & Tian’an Jiang
Pages: 1395-1402
Published online: 13 Mar 2018
AbstractforFast hemostasis: a win–win strategy for ultrasound and microwave ablation | Full Text | References | PDF (4 MB)
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Article
Long non-coding RNA FENDRR inhibits cell proliferation and is associated with good prognosis in breast cancer
Yan Li, Wenwen Zhang, Pengying Liu, Yumei Xu, Lin Tang, Weiwei Chen & Xiaoxiang Guan
Pages: 1403-1412
Published online: 14 Mar 2018
AbstractforLong non-coding RNA FENDRR inhibits cell proliferation and is associated with good prognosis in breast cancer | Full Text | References | PDF (1.5 MB)
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Article
Upregulation of FOXP1 is a new independent unfavorable prognosticator and a specific predictor of lymphatic dissemination in cutaneous melanoma patients
Piotr Donizy, Konrad Pagacz, Jakub Marczuk, Wojciech Fendler, Adam Maciejczyk, Agnieszka Halon & Rafal Matkowski
Pages: 1413-1422
Published online: 14 Mar 2018
AbstractforUpregulation of FOXP1 is a new independent unfavorable prognosticator and a specific predictor of lymphatic dissemination in cutaneous melanoma patients | Full Text | References | PDF (1.2 MB)
  • 75 Views
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Article
Peripheral inflammation/immune indicators of chemosensitivity and prognosis in breast cancer patients treated with neoadjuvant chemotherapy
Yi Qian, Jing Tao, Xiuqing Li, Hua Chen, Qi Lu, Junzhe Yang, Hong Pan, Cong Wang, Wenbin Zhou & Xiaoan Liu
Pages: 1423-1432
Published online: 15 Mar 2018
AbstractforPeripheral inflammation/immune indicators of chemosensitivity and prognosis in breast cancer patients treated with neoadjuvant chemotherapy | Full Text | References | PDF (962.2 KB)
  • 89 Views
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Article
Measurement of serum PODXL concentration for detection of pancreatic cancer
Keisuke Taniuchi, Makiko Tsuboi, Masahiko Sakaguchi & Toshiji Saibara
Pages: 1433-1445
Published online: 15 Mar 2018
AbstractforMeasurement of serum PODXL concentration for detection of pancreatic cancer | Full Text | References | PDF (1.6 MB)
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Article
Modulation of human melanoma cell proliferation and apoptosis by hydatid cyst fluid of Echinococcus granulosus
Xiang-Yang Gao, Guang-Hui Zhang & Li Huang
Pages: 1447-1456
Published online: 14 Nov 2022
AbstractforModulation of human melanoma cell proliferation and apoptosis by hydatid cyst fluid of Echinococcus granulosus | Full Text | References | PDF (5 MB)
  • 96 Views
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Article
Identification of differentially expressed genes and signaling pathways in ovarian cancer by integrated bioinformatics analysis
Xiao Yang, Shaoming Zhu, Li Li, Li Zhang, Shu Xian, Yanqing Wang & Yanxiang Cheng
Pages: 1457-1474
Published online: 15 Mar 2018
AbstractforIdentification of differentially expressed genes and signaling pathways in ovarian cancer by integrated bioinformatics analysis | Full Text | References | PDF (4.7 MB)
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Article
Midazolam activates caspase, MAPKs and endoplasmic reticulum stress pathways, and inhibits cell cycle and Akt pathway, to induce apoptosis in TM3 mouse Leydig progenitor cells
Fu-Chi Kang, Shu-Chun Wang, Ming-Min Chang, Bo-Syong Pan, Kar-Lok Wong, Ka-Shun Cheng, Edmund Cheung So & Bu-Miin Huang
Pages: 1475-1490
Published online: 14 Nov 2022
AbstractforMidazolam activates caspase, MAPKs and endoplasmic reticulum stress pathways, and inhibits cell cycle and Akt pathway, to induce apoptosis in TM3 mouse Leydig progenitor cells | Full Text | References | PDF (2.1 MB)
  • 80 Views
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Article
Upregulated long non-coding RNAs demonstrate promising efficacy for breast cancer detection: a meta-analysis
Guozheng Yu, Wei Zhang, Linyan Zhu & Lin Xia
Pages: 1491-1499
Published online: 16 Mar 2018
AbstractforUpregulated long non-coding RNAs demonstrate promising efficacy for breast cancer detection: a meta-analysis | Full Text | References | PDF (1.3 MB)
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Article
RETRACTED ARTICLE: miR-622 suppresses tumor formation by directly targeting VEGFA in papillary thyroid carcinoma
Renjie Wang, Qingjie Ma, Linlin Ji, Yue Yao, Mengshi Ma & Qiang Wen
Pages: 1501-1509
Published online: 16 Mar 2018
AbstractforRETRACTED ARTICLE: miR-622 suppresses tumor formation by directly targeting VEGFA in papillary thyroid carcinoma | PDF (2.7 MB)
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Article
STK39 blockage by RNA interference inhibits the proliferation and induces the apoptosis of renal cell carcinoma
Qi Zhao, Yanjun Zhu, Li Liu, Hang Wang, Shuai Jiang, Xiaoyi Hu & Jianming Guo
Pages: 1511-1519
Published online: 16 Mar 2018
AbstractforSTK39 blockage by RNA interference inhibits the proliferation and induces the apoptosis of renal cell carcinoma | Full Text | References | PDF (1.9 MB)
  • 72 Views
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Case Report

Case Report
Primary mucinous carcinoma of thyroid gland with prominent signet-ring-cell differentiation: a case report and review of the literature
Jian Wang, Qie-Re Guli, Xiao-Cui Ming, Hai-Tao Zhou, Yong-Jie Cui, Yue-Feng Jiang, Di Zhang & Yang Liu
Pages: 1521-1528
Published online: 16 Mar 2018
AbstractforPrimary mucinous carcinoma of thyroid gland with prominent signet-ring-cell differentiation: a case report and review of the literature | Full Text | References | PDF (7.1 MB)
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Review

Review Article
Functional miRNAs in breast cancer drug resistance
Weizi Hu, Chunli Tan, Yunjie He, Guangqin Zhang, Yong Xu & Jinhai Tang
Pages: 1529-1541
Published online: 19 Mar 2018
AbstractforFunctional miRNAs in breast cancer drug resistance | Full Text | References | PDF (439.3 KB)
  • 425 Views
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Original Research

Article
Novel long noncoding RNA GACAT3 promotes colorectal cancer cell proliferation, invasion, and migration through miR-149
Weiwei Zhou, Lei Wang, Yu Miao & Rongge Xing
Pages: 1543-1552
Published online: 19 Mar 2018
AbstractforNovel long noncoding RNA GACAT3 promotes colorectal cancer cell proliferation, invasion, and migration through miR-149 | Full Text | References | PDF (1.4 MB)
  • 58 Views
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Review

Review Article
Forecast of actin-binding proteins as the oncotarget in osteosarcoma – a review of mechanism, diagnosis and therapy
Yucheng Fu, Wei Yu, Hongliu Cai & Anwei Lu
Pages: 1553-1561
Published online: 14 Nov 2022
AbstractforForecast of actin-binding proteins as the oncotarget in osteosarcoma – a review of mechanism, diagnosis and therapy | Full Text | References | PDF (1.1 MB)
  • 69 Views
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Original Research

Article
Overexpression of HHLA2, a member of the B7 family, is associated with worse survival in human colorectal carcinoma
Ziwen Zhu & Weiguo Dong
Pages: 1563-1570
Published online: 20 Mar 2018
AbstractforOverexpression of HHLA2, a member of the B7 family, is associated with worse survival in human colorectal carcinoma | Full Text | References | PDF (5.7 MB)
  • 138 Views
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Article
High expression of COL10A1 is associated with poor prognosis in colorectal cancer
Haipeng Huang, Tingting Li, Gengtai Ye, Liying Zhao, Zhenzhan Zhang, Debin Mo, Yiming Wang, Ce Zhang, Haijun Deng, Guoxin Li & Hao Liu
Pages: 1571-1581
Published online: 20 Mar 2018
AbstractforHigh expression of COL10A1 is associated with poor prognosis in colorectal cancer | Full Text | References | PDF (7.5 MB)
  • 123 Views
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Article
Hsp90 inhibitor NMS-E973 exerts the anticancer effect against glioblastoma via induction of PUMA-mediated apoptosis
Libo Sun, Shoujun Yang, Guonan Chi & Xingyi Jin
Pages: 1583-1593
Published online: 20 Mar 2018
AbstractforHsp90 inhibitor NMS-E973 exerts the anticancer effect against glioblastoma via induction of PUMA-mediated apoptosis | Full Text | References | PDF (2.6 MB)
  • 65 Views
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Case Report

Case Report
Lung squamous cell carcinoma associated with hypoparathyroidism with sensorineural deafness and renal dysplasia syndrome: a case report
Mariko Kojima, Tatsuya Nagano, Kyosuke Nakata, Shigeo Hara, Naoko Katsurada, Masatsugu Yamamoto, Motoko Tachihara, Hiroshi Kamiryo, Kazuyuki Kobayashi, Takeshi Usui & Yoshihiro Nishimura
Pages: 1595-1599
Published online: 20 Mar 2018
AbstractforLung squamous cell carcinoma associated with hypoparathyroidism with sensorineural deafness and renal dysplasia syndrome: a case report | Full Text | References | PDF (1 MB)
  • 68 Views
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Original Research

Article
Targeting DTL induces cell cycle arrest and senescence and suppresses cell growth and colony formation through TPX2 inhibition in human hepatocellular carcinoma cells
Yu-Chia Chen, I-shu Chen, Guan-Jin Huang, Chi-hsiang Kang, Kuo-Chiang Wang, Min-Jen Tsao & Hung-Wei Pan
Pages: 1601-1616
Published online: 21 Mar 2018
AbstractforTargeting DTL induces cell cycle arrest and senescence and suppresses cell growth and colony formation through TPX2 inhibition in human hepatocellular carcinoma cells | Full Text | References | PDF (5.2 MB)
  • 117 Views
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Article
Tooth loss and risk of colorectal cancer: a dose–response meta-analysis of prospective cohort studies
Peng Ma, Shaojun Dai, Can Jin, Yonggang Yao & Chuanxin Zou
Pages: 1617-1623
Published online: 21 Mar 2018
AbstractforTooth loss and risk of colorectal cancer: a dose–response meta-analysis of prospective cohort studies | Full Text | References | PDF (546.3 KB)
  • 58 Views
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Article
Open adrenalectomy versus laparoscopic adrenalectomy for adrenocortical carcinoma: a retrospective comparative study on short-term oncologic prognosis
Guo-Yang Zheng, Han-Zhong Li, Jian-Hua Deng, Xue-Bin Zhang & Xing-Cheng Wu
Pages: 1625-1632
Published online: 21 Mar 2018
AbstractforOpen adrenalectomy versus laparoscopic adrenalectomy for adrenocortical carcinoma: a retrospective comparative study on short-term oncologic prognosis | Full Text | References | PDF (521.2 KB)
  • 73 Views
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Article
Effects of isoliquiritigenin on ovarian cancer cells
Nan Li, Liang Yang, Xinna Deng & Yanan Sun
Pages: 1633-1642
Published online: 22 Mar 2018
AbstractforEffects of isoliquiritigenin on ovarian cancer cells | Full Text | References | PDF (2.9 MB)
  • 71 Views
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Article
miR-342-3p suppresses hepatocellular carcinoma proliferation through inhibition of IGF-1R-mediated Warburg effect
Wenpeng Liu, Lei Kang, Juqiang Han, Yadong Wang, Chuan Shen, Zhifeng Yan, Yanhong Tai & Caiyan Zhao
Pages: 1643-1653
Published online: 23 Mar 2018
AbstractformiR-342-3p suppresses hepatocellular carcinoma proliferation through inhibition of IGF-1R-mediated Warburg effect | Full Text | References | PDF (1.9 MB)
  • 100 Views
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Article
Biomarker expression in rectal cancer tissue before and after neoadjuvant therapy
Leonora SF Boogerd, Maxime JM van der Valk, Martin C Boonstra, Hendrica AJM Prevoo, Denise E Hilling, Cornelis JH van de Velde, Cornelis FM Sier, Arantza Fariña Sarasqueta & Alexander L Vahrmeijer
Pages: 1655-1664
Published online: 23 Mar 2018
AbstractforBiomarker expression in rectal cancer tissue before and after neoadjuvant therapy | Full Text | References | PDF (1.8 MB)
  • 73 Views
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Article
The incidence of postoperative radiotherapy-induced acute dermatitis in breast cancer and its influencing factors for Chinese women
Jingxian Ding, Yonghong Guo, Qingge Li, Jun Chen, Pinghua Hu, Qiuming Liu, Yali Cao & Jiong Wu
Pages: 1665-1670
Published online: 23 Mar 2018
AbstractforThe incidence of postoperative radiotherapy-induced acute dermatitis in breast cancer and its influencing factors for Chinese women | Full Text | References | PDF (1.8 MB)
  • 114 Views
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Article
MiR-216b suppresses colorectal cancer proliferation, migration, and invasion by targeting SRPK1
Yanfen Yao, Qiaorong Li & Hong Wang
Pages: 1671-1681
Published online: 23 Mar 2018
AbstractforMiR-216b suppresses colorectal cancer proliferation, migration, and invasion by targeting SRPK1 | Full Text | References | PDF (1.8 MB)
  • 61 Views
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Article
Bioinformatic analysis of prognostic value of ZW10 interacting protein in lung cancer
Wen Yuan, Songping Xie, Meng Wang, Shan Pan, Xiaoxing Huang, Meng Xiong, Rui-jing Xiao, Jie Xiong, Qiu-ping Zhang & Liang Shao
Pages: 1683-1695
Published online: 23 Mar 2018
AbstractforBioinformatic analysis of prognostic value of ZW10 interacting protein in lung cancer | Full Text | References | PDF (7.2 MB)
  • 145 Views
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Article
Upregulated VEGFA and DLL4 act as potential prognostic genes for clear cell renal cell carcinoma
Xilong Wang, Jun Zhang, Yangyun Wang, Minqi Tu, Ying Wang & Guowei Shi
Pages: 1697-1706
Published online: 14 Nov 2022
AbstractforUpregulated VEGFA and DLL4 act as potential prognostic genes for clear cell renal cell carcinoma | Full Text | References | PDF (2.6 MB)
  • 62 Views
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Article
KIF18B promotes tumor progression through activating the Wnt/β-catenin pathway in cervical cancer
Yaqin Wu, Anpeng Wang, Biqing Zhu, Jian Huang, Emei Lu, Hanzi Xu, Wenjie Xia, Gaochao Dong, Feng Jiang & Lin Xu
Pages: 1707-1720
Published online: 28 Mar 2018
AbstractforKIF18B promotes tumor progression through activating the Wnt/β-catenin pathway in cervical cancer | Full Text | References | PDF (9.7 MB)
  • 115 Views
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Article
miR-1269 promotes cell survival and proliferation by targeting tp53 and caspase-9 in lung cancer
Min Bao, Yingjian Song, Jingjing Xia, Pengling Li, Qing Liu & Zongren Wan
Pages: 1721-1732
Published online: 26 Mar 2018
AbstractformiR-1269 promotes cell survival and proliferation by targeting tp53 and caspase-9 in lung cancer | Full Text | References | PDF (2.8 MB)
  • 77 Views
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Article
MiR-152 functioning as a tumor suppressor that interacts with DNMT1 in nasopharyngeal carcinoma
Zhi-Wei Lu, Ming-Yu Du, Lu-Xi Qian, Nan Zhang, Jia-Jia Gu, Kai Ding, Jing Wu, Hong-Ming Zhu, Xia He & Li Yin
Pages: 1733-1741
Published online: 27 Mar 2018
AbstractforMiR-152 functioning as a tumor suppressor that interacts with DNMT1 in nasopharyngeal carcinoma | Full Text | References | PDF (2.6 MB)
  • 61 Views
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Article
Antibody-sandwich ELISA analysis of a novel blood biomarker of CST4 in gastrointestinal cancers
Yaling Dou, Yali Lv, Xiaojin Zhou, Linfu He, Lihong Liu, Pengfei Li, Yulong Sun, Minghui Wang, Meijuan Gao & Chong Wang
Pages: 1743-1756
Published online: 28 Mar 2018
AbstractforAntibody-sandwich ELISA analysis of a novel blood biomarker of CST4 in gastrointestinal cancers | Full Text | References | PDF (3.5 MB)
  • 262 Views
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Article
miR-206 regulates 5-FU resistance by targeting Bcl-2 in colon cancer cells
Xiaomin Meng & Rao Fu
Pages: 1757-1765
Published online: 14 Nov 2022
AbstractformiR-206 regulates 5-FU resistance by targeting Bcl-2 in colon cancer cells | Full Text | References | PDF (2 MB)
  • 107 Views
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Article
Metformin inhibits proliferation and cytotoxicity and induces apoptosis via AMPK pathway in CD19-chimeric antigen receptor-modified T cells
Qian Mu, Miao Jiang, Yuzhu Zhang, Fei Wu, Hui Li, Wen Zhang, Fang Wang, Jiang Liu, Liang Li, Dongshan Wang, Wenjuan Wang, Shiwu Li, Haibo Song & Dongqi Tang
Pages: 1767-1776
Published online: 03 Apr 2018
AbstractforMetformin inhibits proliferation and cytotoxicity and induces apoptosis via AMPK pathway in CD19-chimeric antigen receptor-modified T cells | Full Text | References | PDF (1.6 MB)
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Article
Synergistic antitumor effects of tanshinone IIA and sorafenib or its derivative SC-1 in hepatocellular carcinoma cells
Chien-Ming Chiu, Sung-Ying Huang, Shu-Fang Chang, Kuan-Fu Liao & Sheng-Chun Chiu
Pages: 1777-1785
Published online: 14 Nov 2022
AbstractforSynergistic antitumor effects of tanshinone IIA and sorafenib or its derivative SC-1 in hepatocellular carcinoma cells | Full Text | References | PDF (2.1 MB)
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Review

Review Article
Prognostic value of increased integrin-beta 1 expression in solid cancers: a meta-analysis
Quanwu Sun, Chuan Zhou, Ruofei Ma, Qianhong Guo, Haiyun Huang, Jie Hao, Hong Liu, Rong Shi & Bo Liu
Pages: 1787-1799
Published online: 29 Mar 2018
AbstractforPrognostic value of increased integrin-beta 1 expression in solid cancers: a meta-analysis | Full Text | References | PDF (1.7 MB)
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Original Research

Article
Association between WWOX and the risk of malignant tumor, especially among Asians: evidence from a meta-analysis
Hao Yuan, Yang Wu, Jingjing Zhang, Guodong Shi, Dongfang Liu, Yuan He, Zipeng Lu, Pengfei Wu, Kuirong Jiang & Yi Miao
Pages: 1801-1811
Published online: 14 Nov 2022
AbstractforAssociation between WWOX and the risk of malignant tumor, especially among Asians: evidence from a meta-analysis | Full Text | References | PDF (2.4 MB)
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Case Report

Case Report
Rare malignant insulinoma with multiple liver metastases derived from ectopic pancreas: 3-year follow-up and literature review
Qing Liu, Jianghui Duan, Yumin Zheng, Jie Luo, Xiaopin Cai & Huangying Tan
Pages: 1813-1819
Published online: 03 Apr 2018
AbstractforRare malignant insulinoma with multiple liver metastases derived from ectopic pancreas: 3-year follow-up and literature review | Full Text | References | PDF (1.8 MB)
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Original Research

Article
Clinicopathological characteristics and prognostic value of the cancer stem cell marker ALDH1 in ovarian cancer: a meta-analysis
Wenge Zhao, Chuanxin Zang, Tingting Zhang, Jia Li, Ruijuan Liu, Fubin Feng, Qingliang Lv, Liang Zheng, Jinhui Tian & Changgang Sun
Pages: 1821-1831
Published online: 03 Apr 2018
AbstractforClinicopathological characteristics and prognostic value of the cancer stem cell marker ALDH1 in ovarian cancer: a meta-analysis | Full Text | References | PDF (2.2 MB)
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Article
d-limonene exhibits antitumor activity by inducing autophagy and apoptosis in lung cancer
Xiao Yu, Hongyan Lin, Yu Wang, Wenwen Lv, Shuo Zhang, Ying Qian, Xiaobei Deng, Nannan Feng, Herbert Yu & Biyun Qian
Pages: 1833-1847
Published online: 04 Apr 2018
Abstractford-limonene exhibits antitumor activity by inducing autophagy and apoptosis in lung cancer | Full Text | References | PDF (8.9 MB)
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Article
Integrated bioinformatic analysis unveils significant genes and pathways in the pathogenesis of supratentorial primitive neuroectodermal tumor
Guang-Yu Wang, Ling Li, Bo Liu, Xiao Han, Chun-Hua Wang & Ji-Wen Wang
Pages: 1849-1859
Published online: 04 Apr 2018
AbstractforIntegrated bioinformatic analysis unveils significant genes and pathways in the pathogenesis of supratentorial primitive neuroectodermal tumor | Full Text | References | PDF (11.8 MB)
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Article
Identification of molecular target genes and key pathways in hepatocellular carcinoma by bioinformatics analysis
Lei Zhou, Yanyan Du, Lingqun Kong, Xingyuan Zhang & Qiangpu Chen
Pages: 1861-1869
Published online: 14 Nov 2022
AbstractforIdentification of molecular target genes and key pathways in hepatocellular carcinoma by bioinformatics analysis | Full Text | References | PDF (598.5 KB)
  • 388 Views
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Article
Antiangiogenic effects of AA-PMe on HUVECs in vitro and zebrafish in vivo
Yue Jing, Gang Wang, Qi Xiao, Yachun Zhou, Yingjie Wei & Zhunan Gong
Pages: 1871-1884
Published online: 04 Apr 2018
AbstractforAntiangiogenic effects of AA-PMe on HUVECs in vitro and zebrafish in vivo | Full Text | References | PDF (4.3 MB)
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Case Report

Case Report
Long-term survival with transarterial chemoembolization and radioembolization in a patient with cancers of unknown primary
Gokmen Aktas, Tulay Kus, Taylan Metin, Selim Kervancioglu & Umut Elboga
Pages: 1885-1889
Published online: 04 Apr 2018
AbstractforLong-term survival with transarterial chemoembolization and radioembolization in a patient with cancers of unknown primary | Full Text | References | PDF (1.7 MB)
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Original Research

Article
99mTc-labeled sodium phytate and stannous chloride injection accurately detects sentinel lymph node in axillary of early stage breast cancer: a randomized, controlled study
Suisheng Yang, Weiyu Bao, Xiaorong Bai, Chen Gao, Binming Zhang & Zhuanji Jiang
Pages: 1891-1898
Published online: 04 Apr 2018
Abstractfor99mTc-labeled sodium phytate and stannous chloride injection accurately detects sentinel lymph node in axillary of early stage breast cancer: a randomized, controlled study | Full Text | References | PDF (892.1 KB)
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Review

Review Article
Prognostic value of platelet-to-lymphocyte ratio in pancreatic cancer: a comprehensive meta-analysis of 17 cohort studies
Yongping Zhou, Sijin Cheng, Abdel Hamid Fathy, Haixin Qian & Yongzhao Zhao
Pages: 1899-1908
Published online: 05 Apr 2018
AbstractforPrognostic value of platelet-to-lymphocyte ratio in pancreatic cancer: a comprehensive meta-analysis of 17 cohort studies | Full Text | References | PDF (1 MB)
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Original Research

Article
miR-495 inhibits proliferation, migration, and invasion and induces apoptosis via inhibiting PBX3 in melanoma cells
Guangxiong Chen & Yijie Xie
Pages: 1909-1920
Published online: 05 Apr 2018
AbstractformiR-495 inhibits proliferation, migration, and invasion and induces apoptosis via inhibiting PBX3 in melanoma cells | Full Text | References | PDF (3.8 MB)
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Case Report

Case Report
PET-CT evaluation of the curative effect of crizotinib on malignant myofibroblastoma with rare mutation of ALK R401: a case report and literature review
Li Yang, Yufeng Wu, Hong Tang, Jiuzhou Zhao, Dongdong Zhao, Sen Yang & Qiming Wang
Pages: 1921-1927
Published online: 05 Apr 2018
AbstractforPET-CT evaluation of the curative effect of crizotinib on malignant myofibroblastoma with rare mutation of ALK R401: a case report and literature review | Full Text | References | PDF (10.4 MB)
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Original Research

Article
Downregulation of miR-542-3p promotes cancer metastasis through activating TGF-β/Smad signaling in hepatocellular carcinoma
Tong Zhang, Wei Liu, Wei Meng, Hui Zhao, Qing Yang, Shi-jie Gu, Cui-cui Xiao, Chang-chang Jia & Bin-sheng Fu
Pages: 1929-1939
Published online: 05 Apr 2018
AbstractforDownregulation of miR-542-3p promotes cancer metastasis through activating TGF-β/Smad signaling in hepatocellular carcinoma | Full Text | References | PDF (3.6 MB)
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Article
Inhibition of NIPBL enhances the chemosensitivity of non-small-cell lung cancer cells via the DNA damage response and autophagy pathway
Lei Zheng, Huanhuan Zhou, Liwei Guo, Xiaoling Xu, Shengjie Zhang, Weizhen Xu & Weimin Mao
Pages: 1941-1948
Published online: 14 Nov 2022
AbstractforInhibition of NIPBL enhances the chemosensitivity of non-small-cell lung cancer cells via the DNA damage response and autophagy pathway | Full Text | References | PDF (2.9 MB)
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Article
Fabrication of ultrasmall WS2 quantum dots-coated periodic mesoporous organosilica nanoparticles for intracellular drug delivery and synergistic chemo-photothermal therapy
Wenyun Liao, Li Zhang, Yunhua Zhong, Yuan Shen, Changlin Li & Na An
Pages: 1949-1960
Published online: 05 Apr 2018
AbstractforFabrication of ultrasmall WS2 quantum dots-coated periodic mesoporous organosilica nanoparticles for intracellular drug delivery and synergistic chemo-photothermal therapy | Full Text | References | PDF (4.5 MB)
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Article
RETRACTED ARTICLE: Knockdown of fibrous sheath interacting protein 1 expression reduces bladder urothelial carcinoma cell proliferation and induces apoptosis via inhibition of the PI3K/AKT pathway
Ming Sun, Zhaofu Chen, Shutao Tan, Caigang Liu & Wenyan Zhao
Pages: 1961-1971
Published online: 05 Apr 2018
AbstractforRETRACTED ARTICLE: Knockdown of fibrous sheath interacting protein 1 expression reduces bladder urothelial carcinoma cell proliferation and induces apoptosis via inhibition of the PI3K/AKT pathway | PDF (5.9 MB)
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Article
Postmastectomy radiotherapy reduces locoregional and disease recurrence in patients with stage II–III triple-negative breast cancer treated with neoadjuvant chemotherapy and mastectomy
Xingxing Chen, Fan Xia, Jurui Luo, Jinli Ma, Zhaozhi Yang, Li Zhang, Yan Feng, Zhimin Shao, Xiaoli Yu & Xiaomao Guo
Pages: 1973-1980
Published online: 05 Apr 2018
AbstractforPostmastectomy radiotherapy reduces locoregional and disease recurrence in patients with stage II–III triple-negative breast cancer treated with neoadjuvant chemotherapy and mastectomy | Full Text | References | PDF (396.7 KB)
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Article
Positioning error and expanding margins of planning target volume with kilovoltage cone beam computed tomography for prostate cancer radiotherapy
Gang Wang, Wen-Ling Wang, Yi-Qun Liu, Hong-Min Dong & Yin-Xiang Hu
Pages: 1981-1988
Published online: 06 Apr 2018
AbstractforPositioning error and expanding margins of planning target volume with kilovoltage cone beam computed tomography for prostate cancer radiotherapy | Full Text | References | PDF (405.7 KB)
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Case Series

Article
Multiline treatment combining apatinib with toptecan for platinum-resistant recurrent ovarian cancer patients: a report of three cases
Yuan Cheng, Juan Zhang, Haiyun Geng, Shukui Qin & Haiqing Hua
Pages: 1989-1995
Published online: 06 Apr 2018
AbstractforMultiline treatment combining apatinib with toptecan for platinum-resistant recurrent ovarian cancer patients: a report of three cases | Full Text | References | PDF (926 KB)
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Original Research

Article
Role of presurgical targeted molecular therapy in renal cell carcinoma with an inferior vena cava tumor thrombus
Cheng Peng, Liangyou Gu, Lei Wang, Qingbo Huang, Baojun Wang, Gang Guo, Yang Fan, Yu Gao, Xin Ma & Xu Zhang
Pages: 1997-2005
Published online: 06 Apr 2018
AbstractforRole of presurgical targeted molecular therapy in renal cell carcinoma with an inferior vena cava tumor thrombus | Full Text | References | PDF (1.5 MB)
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Article
Butein activates p53 in hepatocellular carcinoma cells via blocking MDM2-mediated ubiquitination
Yuanfeng Zhou, Kuifeng Wang, Ni Zhou, Tingting Huang, Jiansheng Zhu & Jicheng Li
Pages: 2007-2015
Published online: 06 Apr 2018
AbstractforButein activates p53 in hepatocellular carcinoma cells via blocking MDM2-mediated ubiquitination | Full Text | References | PDF (1.6 MB)
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Article
Crocin induces autophagic apoptosis in hepatocellular carcinoma by inhibiting Akt/mTOR activity
Chong Yao, Bing-Bing Liu, Xiao-Dong Qian, Li-Qin Li, Heng-Bin Cao, Qiao-Sheng Guo & Gui-Fen Zhou
Pages: 2017-2028
Published online: 09 Apr 2018
AbstractforCrocin induces autophagic apoptosis in hepatocellular carcinoma by inhibiting Akt/mTOR activity | Full Text | References | PDF (3.4 MB)
  • 128 Views
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Article
β-Catenin-driven adrenocortical carcinoma is characterized with immune exclusion
Shenghua Liu, Guanxiong Ding, Zhongwen Zhou & Chenchen Feng
Pages: 2029-2036
Published online: 09 Apr 2018
Abstractforβ-Catenin-driven adrenocortical carcinoma is characterized with immune exclusion | Full Text | References | PDF (3.4 MB)
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Article
IL-21-secreting hUCMSCs combined with miR-200c inhibit tumor growth and metastasis via repression of Wnt/β-catenin signaling and epithelial–mesenchymal transition in epithelial ovarian cancer
Yunxia Zhang, Jing Wang, Di Wu, Miao Li, Fenshu Zhao, Mulan Ren, Yunlong Cai & Jun Dou
Pages: 2037-2050
Published online: 10 Apr 2018
AbstractforIL-21-secreting hUCMSCs combined with miR-200c inhibit tumor growth and metastasis via repression of Wnt/β-catenin signaling and epithelial–mesenchymal transition in epithelial ovarian cancer | Full Text | References | PDF (4 MB)
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Article
Combination of SIRT1 and Src overexpression suggests poor prognosis in luminal breast cancer
Jie Tan, Yuyin Liu, Yusufu Maimaiti, Changwen Wang, Yu Yan, Jing Zhou, Shengnan Ruan & Tao Huang
Pages: 2051-2061
Published online: 11 Apr 2018
AbstractforCombination of SIRT1 and Src overexpression suggests poor prognosis in luminal breast cancer | Full Text | References | PDF (2 MB)
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Review

Review Article
Role of the NFκB-signaling pathway in cancer
Longzheng Xia, Shiming Tan, Yujuan Zhou, Jingguan Lin, Heran Wang, Linda Oyang, Yutong Tian, Lu Liu, Min Su, Hui Wang, Deliang Cao & Qianjin Liao
Pages: 2063-2073
Published online: 11 Apr 2018
AbstractforRole of the NFκB-signaling pathway in cancer | Full Text | References | PDF (750.8 KB)
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Original Research

Article
Expression of pyruvate kinase M2 in human bladder cancer and its correlation with clinical parameters and prognosis
Changkun Huang, Zhichao Huang, Peiming Bai, Guangcheng Luo, Xiaokun Zhao & Xinjun Wang
Pages: 2075-2082
Published online: 11 Apr 2018
AbstractforExpression of pyruvate kinase M2 in human bladder cancer and its correlation with clinical parameters and prognosis | Full Text | References | PDF (1.6 MB)
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Article
Investigation of LEP and LEPR polymorphisms with the risk of hepatocellular carcinoma: a case–control study in Eastern Chinese Han population
Sheng Zhang, Jiakai Jiang, Zhan Chen, Yafeng Wang, Weifeng Tang, Chao Liu, Longgen Liu & Yu Chen
Pages: 2083-2089
Published online: 11 Apr 2018
AbstractforInvestigation of LEP and LEPR polymorphisms with the risk of hepatocellular carcinoma: a case–control study in Eastern Chinese Han population | Full Text | References | PDF (309.4 KB)
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Article
Four cycles of adriamycin and cyclophosphamide followed by four cycles of docetaxel (NSABP-B27) with concomitant trastuzumab as neoadjuvant therapy for high-risk, early-stage, HER2-positive breast cancer patients
Hikmat Abdel-Razeq, Salwa S Saadeh, Mahmoud Abu-Nasser, Hazem Abdulelah, Lina Marie, Murad Salam, Basel Al-Haj Ali, Mohammad Ibrahim & Dalia Rimawi
Pages: 2091-2096
Published online: 11 Apr 2018
AbstractforFour cycles of adriamycin and cyclophosphamide followed by four cycles of docetaxel (NSABP-B27) with concomitant trastuzumab as neoadjuvant therapy for high-risk, early-stage, HER2-positive breast cancer patients | Full Text | References | PDF (592.3 KB)
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Article
Small ubiquitin-like modifier 1 modification of pyruvate kinase M2 promotes aerobic glycolysis and cell proliferation in A549 human lung cancer cells
Shuxian An, Liangqian Huang, Ping Miao, Liang Shi, Mengqin Shen, Xiaoping Zhao, Jianjun Liu & Gang Huang
Pages: 2097-2109
Published online: 13 Apr 2018
AbstractforSmall ubiquitin-like modifier 1 modification of pyruvate kinase M2 promotes aerobic glycolysis and cell proliferation in A549 human lung cancer cells | Full Text | References | PDF (2.4 MB)
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Article
Overexpression of high mobility group box 1 contributes to progressive clinicopathological features and poor prognosis of human bladder urothelial carcinoma
Changkun Huang, Zhichao Huang, Xiaokun Zhao, Yinhuai Wang, Hongqing Zhao, Zhaohui Zhong & Lang Wang
Pages: 2111-2120
Published online: 12 Apr 2018
AbstractforOverexpression of high mobility group box 1 contributes to progressive clinicopathological features and poor prognosis of human bladder urothelial carcinoma | Full Text | References | PDF (1.7 MB)
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Review

Review Article
Efficacy of pemetrexed-based regimens in advanced non–small cell lung cancer patients with activating epidermal growth factor receptor mutations after tyrosine kinase inhibitor failure: a systematic review
BaoHui Han, LuLu Yang, Xin Wang & LuanDi Yao
Pages: 2121-2129
Published online: 14 Nov 2022
AbstractforEfficacy of pemetrexed-based regimens in advanced non–small cell lung cancer patients with activating epidermal growth factor receptor mutations after tyrosine kinase inhibitor failure: a systematic review | Full Text | References | PDF (395.1 KB)
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Original Research

Article
Albumin/globulin ratio is negatively correlated with PD-1 and CD25 mRNA levels in breast cancer patients
Chao Liu, Wei Wang, Xiangying Meng, Bing Sun, Yang Cong, Jiannan Liu, Qian Wang, Guangxian Liu & Shikai Wu
Pages: 2131-2139
Published online: 12 Apr 2018
AbstractforAlbumin/globulin ratio is negatively correlated with PD-1 and CD25 mRNA levels in breast cancer patients | Full Text | References | PDF (1.2 MB)
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Review

Review Article
Profile of apalutamide in the treatment of metastatic castration-resistant prostate cancer: evidence to date
Julio T Chong, William K Oh & Bobby C Liaw
Pages: 2141-2147
Published online: 12 Apr 2018
AbstractforProfile of apalutamide in the treatment of metastatic castration-resistant prostate cancer: evidence to date | Full Text | References | PDF (258.5 KB)
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Article
Multiple treatment modalities for brain metastasis in patients with EGFR-mutant non-small-cell lung cancer
Haiyang Wang, Xiaoqing Yu, Yun Fan & Youhua Jiang
Pages: 2149-2155
Published online: 13 Apr 2018
AbstractforMultiple treatment modalities for brain metastasis in patients with EGFR-mutant non-small-cell lung cancer | Full Text | References | PDF (442.9 KB)
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Article
Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis
Yongping Zhou, Sijin Cheng, Sinuo Chen & Yongzhao Zhao
Pages: 2157-2167
Published online: 13 Apr 2018
AbstractforPrognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis | Full Text | References | PDF (1.1 MB)
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Article
Preoperative apolipoprotein B/apolipoprotein A1 ratio: a novel prognostic factor for gastric cancer
Ming-zhe Ma, Shu-qiang Yuan, Yong-ming Chen & Zhi-wei Zhou
Pages: 2169-2176
Published online: 13 Apr 2018
AbstractforPreoperative apolipoprotein B/apolipoprotein A1 ratio: a novel prognostic factor for gastric cancer | Full Text | References | PDF (1.5 MB)
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Article
Overexpression of HDAC9 is associated with poor prognosis and tumor progression of breast cancer in Chinese females
Yixiang Huang, Wei Jian, Junyong Zhao & Gang Wang
Pages: 2177-2184
Published online: 17 Apr 2018
AbstractforOverexpression of HDAC9 is associated with poor prognosis and tumor progression of breast cancer in Chinese females | Full Text | References | PDF (896.3 KB)
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Review

Review Article
The role of Hippo signal pathway in breast cancer metastasis
Changran Wei, Ying Wang & Xiangqi Li
Pages: 2185-2193
Published online: 17 Apr 2018
AbstractforThe role of Hippo signal pathway in breast cancer metastasis | Full Text | References | PDF (441.3 KB)
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Original Research

Article
miR-30a suppresses osteosarcoma proliferation and metastasis by downregulating MEF2D expression
Liuxue Du, Tianpei Chen, Kai Zhao & Dong Yang
Pages: 2195-2202
Published online: 14 Nov 2022
AbstractformiR-30a suppresses osteosarcoma proliferation and metastasis by downregulating MEF2D expression | Full Text | References | PDF (1.1 MB)
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Erratum

Correction
MicroRNA 302b-3p/302c-3p/302d-3p inhibits epithelial–mesenchymal transition and promotes apoptosis in human endometrial carcinoma cells [Erratum]
Page: 2203
Published online: 17 Apr 2018
CitationforMicroRNA 302b-3p/302c-3p/302d-3p inhibits epithelial–mesenchymal transition and promotes apoptosis in human endometrial carcinoma cells [Erratum] | Full Text | PDF (235.1 KB)
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Original Research

Article
RETRACTED ARTICLE: miR-488 inhibits cell growth and metastasis in renal cell carcinoma by targeting HMGN5
Xin Wei, Lili Yu & Xiangbo Kong
Pages: 2205-2216
Published online: 18 Apr 2018
AbstractforRETRACTED ARTICLE: miR-488 inhibits cell growth and metastasis in renal cell carcinoma by targeting HMGN5 | PDF (2 MB)
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Article
EGFR, KRAS, BRAF, PTEN, and PIK3CA mutation in plasma of small cell lung cancer patients
Hong-Yang Lu, Jing Qin, Na Han, Lei Lei, Fajun Xie & Chenghui Li
Pages: 2217-2226
Published online: 20 Apr 2018
AbstractforEGFR, KRAS, BRAF, PTEN, and PIK3CA mutation in plasma of small cell lung cancer patients | Full Text | References | PDF (1.4 MB)
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Article
microRNA-26a induces a mitochondrial apoptosis mediated by p53 through targeting to inhibit Mcl1 in human hepatocellular carcinoma
Xiao-Mei Gao, Ying Zhu, Jian-Hua Li, Xiang-Yu Wang, Xiao-Fei Zhang, Chen-He Yi & Xin Yang
Pages: 2227-2239
Published online: 19 Apr 2018
AbstractformicroRNA-26a induces a mitochondrial apoptosis mediated by p53 through targeting to inhibit Mcl1 in human hepatocellular carcinoma | Full Text | References | PDF (5.1 MB)
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Article
Cardiotoxic effects of the novel approved anti-ErbB2 agents and reverse cardioprotective effects of ranolazine
Claudia De Lorenzo, Rolando Paciello, Gennaro Riccio, Domenica Rea, Antonio Barbieri, Carmela Coppola & Nicola Maurea
Pages: 2241-2250
Published online: 19 Apr 2018
AbstractforCardiotoxic effects of the novel approved anti-ErbB2 agents and reverse cardioprotective effects of ranolazine | Full Text | References | PDF (1.7 MB)
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Article
Evidence from an updated meta-analysis of the prognostic impacts of postoperative radiotherapy and chemotherapy in patients with anaplastic thyroid carcinoma
Quansong Xia, Wei Wang, Juan Xu, Xue Chen, Zhaoming Zhong & Chuanzheng Sun
Pages: 2251-2257
Published online: 19 Apr 2018
AbstractforEvidence from an updated meta-analysis of the prognostic impacts of postoperative radiotherapy and chemotherapy in patients with anaplastic thyroid carcinoma | Full Text | References | PDF (528.8 KB)
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Article
Role of DiGeorge syndrome critical region gene 9, a long noncoding RNA, in gastric cancer
Chao Ni, Ping Yang, Junming Guo & Meng Ye
Pages: 2259-2267
Published online: 19 Apr 2018
AbstractforRole of DiGeorge syndrome critical region gene 9, a long noncoding RNA, in gastric cancer | Full Text | References | PDF (1.5 MB)
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Article
Prediction of tumor mutation burden in breast cancer based on the expression of ER, PR, HER-2, and Ki-67
Junnan Xu, Xiangyu Guo, Mingxi Jing & Tao Sun
Pages: 2269-2275
Published online: 19 Apr 2018
AbstractforPrediction of tumor mutation burden in breast cancer based on the expression of ER, PR, HER-2, and Ki-67 | Full Text | References | PDF (688.5 KB)
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Corrigendum

Correction
Modulation of human melanoma cell proliferation and apoptosis by hydatid cyst fluid of Echinococcus granulosus [Corrigendum]
Page: 2277
Published online: 30 Apr 2018
CitationforModulation of human melanoma cell proliferation and apoptosis by hydatid cyst fluid of Echinococcus granulosus [Corrigendum] | Full Text | PDF (161.5 KB)
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Original Research

Article
Oncogene mutational analysis in Chinese gastrointestinal stromal tumor patients
Qiong Chen, Rong Li, Zhi-Gao Zhang, Qiao-Ting Deng, Kun Li, Hao Wang, Xue-Xi Yang & Ying-Song Wu
Pages: 2279-2286
Published online: 20 Apr 2018
AbstractforOncogene mutational analysis in Chinese gastrointestinal stromal tumor patients | Full Text | References | PDF (432.5 KB)
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Review

Review Article
Forodesine in the treatment of relapsed/refractory peripheral T-cell lymphoma: an evidence-based review
Shinichi Makita, Akiko Miyagi Maeshima, Dai Maruyama, Koji Izutsu & Kensei Tobinai
Pages: 2287-2293
Published online: 20 Apr 2018
AbstractforForodesine in the treatment of relapsed/refractory peripheral T-cell lymphoma: an evidence-based review | Full Text | References | PDF (3.2 MB)
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Article
Neuroendocrine tumor of the common bile duct: a case report and review of the literature
Zhong Liu, Deng-Yong Zhang, Zheng Lu, Pei Zhang, Wan-Liang Sun, Xiang Ma, Hua Wu, Bin-Quan Wu & Shuo Zhou
Pages: 2295-2301
Published online: 23 Apr 2018
AbstractforNeuroendocrine tumor of the common bile duct: a case report and review of the literature | Full Text | References | PDF (4 MB)
  • 104 Views
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Case Report

Case Report
Effectiveness of afatinib after ineffectiveness of gefitinib in an advanced lung adenocarcinoma patient with a single EGFR exon 20 S768I mutation: a case report
Hua Duan, Yanmei Peng, Huijuan Cui, Yuqin Qiu, Qiang Li, Jingyi Zhang, Wen Shen, Chenyao Sun & Chufan Luo
Pages: 2303-2309
Published online: 23 Apr 2018
AbstractforEffectiveness of afatinib after ineffectiveness of gefitinib in an advanced lung adenocarcinoma patient with a single EGFR exon 20 S768I mutation: a case report | Full Text | References | PDF (3.4 MB)
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Original Research

Article
Risk factors for esophageal fistula in patients with locally advanced esophageal carcinoma receiving chemoradiotherapy
Yang Zhang, Zongjuan Li, Wei Zhang, Wei Chen & Yipeng Song
Pages: 2311-2317
Published online: 23 Apr 2018
AbstractforRisk factors for esophageal fistula in patients with locally advanced esophageal carcinoma receiving chemoradiotherapy | Full Text | References | PDF (1.4 MB)
  • 85 Views
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Article
MicroRNA-150 suppresses triple-negative breast cancer metastasis through targeting HMGA2
Wentao Tang, Pingping Xu, Hong Wang, Zhengchuan Niu, Dexiang Zhu, Qi Lin, Liming Tang & Li Ren
Pages: 2319-2332
Published online: 24 Apr 2018
AbstractforMicroRNA-150 suppresses triple-negative breast cancer metastasis through targeting HMGA2 | Full Text | References | PDF (4.6 MB)
  • 97 Views
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Article
Combination of long noncoding RNA MALAT1 and carcinoembryonic antigen for the diagnosis of malignant pleural effusion caused by lung cancer
Wan-Wei Wang, Xi-Lei Zhou, Ying-Jian Song, Chang-Hua Yu, Wei-Guo Zhu & Yu-Suo Tong
Pages: 2333-2344
Published online: 24 Apr 2018
AbstractforCombination of long noncoding RNA MALAT1 and carcinoembryonic antigen for the diagnosis of malignant pleural effusion caused by lung cancer | Full Text | References | PDF (2.3 MB)
  • 63 Views
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Article
The effect of icotinib combined with chemotherapy in untreated non-small-cell lung cancer that harbored EGFR-sensitive mutations in a real-life setting: a retrospective analysis
Lulu Wang, Yan Li, Luchun Li, Zhijuan Wu, Dan Yang, Huiwen Ma & Donglin Wang
Pages: 2345-2353
Published online: 26 Apr 2018
AbstractforThe effect of icotinib combined with chemotherapy in untreated non-small-cell lung cancer that harbored EGFR-sensitive mutations in a real-life setting: a retrospective analysis | Full Text | References | PDF (1.2 MB)
  • 58 Views
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Article
Retrospective study of survival in human papillomavirus-negative oropharyngeal squamous cell carcinoma treated with primary surgery and associated prognostic factors
Yuan Yuan, Lin Wang, Qing-Xiang Li, Jian-Yun Zhang, Zhi-Xiu Xu & Chuan-Bin Guo
Pages: 2355-2362
Published online: 27 Apr 2018
AbstractforRetrospective study of survival in human papillomavirus-negative oropharyngeal squamous cell carcinoma treated with primary surgery and associated prognostic factors | Full Text | References | PDF (888.4 KB)
  • 55 Views
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Article
LDH-Apromotes epithelial–mesenchymal transition by upregulating ZEB2 in intestinal-type gastric cancer
Yongjie Zhang, Sen Lin, Yan Chen, Fei Yang & Shenlin Liu
Pages: 2363-2373
Published online: 27 Apr 2018
AbstractforLDH-Apromotes epithelial–mesenchymal transition by upregulating ZEB2 in intestinal-type gastric cancer | Full Text | References | PDF (1.8 MB)
  • 61 Views
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Article
MicroRNA-328 inhibits migration and epithelial–mesenchymal transition by targeting CD44 in nasopharyngeal carcinoma cells
Chien-Hung Lin, Ming-Chang Chiang & Yann-Jang Chen
Pages: 2375-2385
Published online: 27 Apr 2018
AbstractforMicroRNA-328 inhibits migration and epithelial–mesenchymal transition by targeting CD44 in nasopharyngeal carcinoma cells | Full Text | References | PDF (1.3 MB)
  • 78 Views
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Article
Role of Beclin1 expression in patients with hepatocellular carcinoma: a meta-analysis
Chaojie Liang, Wei Li, Hua Ge, Kaitong Zhang, Guangming Li & Jixiang Wu
Pages: 2387-2397
Published online: 27 Apr 2018
AbstractforRole of Beclin1 expression in patients with hepatocellular carcinoma: a meta-analysis | Full Text | References | PDF (2.3 MB)
  • 61 Views
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Clinical Trial Report

Article
A Phase Ib study of ruxolitinib + gemcitabine ± nab-paclitaxel in patients with advanced solid tumors
Todd M Bauer, Manish R Patel, Andres Forero-Torres, Thomas J George Jr, Albert Assad, Yining Du & Herbert Hurwitz
Pages: 2399-2407
Published online: 30 Apr 2018
AbstractforA Phase Ib study of ruxolitinib + gemcitabine ± nab-paclitaxel in patients with advanced solid tumors | Full Text | References | PDF (511.7 KB)
  • 53 Views
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Original Research

Article
Peptide SA12 inhibits proliferation of breast cancer cell lines MCF-7 and MDA-MB-231 through G0/G1 phase cell cycle arrest
Longfei Yang, Huanran Liu, Min Long, Xi Wang, Fang Lin, Zhaowei Gao & Huizhong Zhang
Pages: 2409-2417
Published online: 30 Apr 2018
AbstractforPeptide SA12 inhibits proliferation of breast cancer cell lines MCF-7 and MDA-MB-231 through G0/G1 phase cell cycle arrest | Full Text | References | PDF (1.4 MB)
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Review

Review Article
A meta-analytic review of the association between two common SNPs in miRNAs and lung cancer susceptibility
Sha Xiao, Songzan Sun, Wenfang Long, Shicheng Kuang, Yunru Liu, Hairong Huang, Jing Zhou, Yongjiang Zhou & Xiaobo Lu
Pages: 2419-2427
Published online: 30 Apr 2018
AbstractforA meta-analytic review of the association between two common SNPs in miRNAs and lung cancer susceptibility | Full Text | References | PDF (844.5 KB)
  • 78 Views
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Original Research

Article
Role of miR-613 as a tumor suppressor in glioma cells by targeting SOX9
Qiuling Sang, Xuejuan Liu & Daju Sun
Pages: 2429-2438
Published online: 30 Apr 2018
AbstractforRole of miR-613 as a tumor suppressor in glioma cells by targeting SOX9 | Full Text | References | PDF (3.9 MB)
  • 55 Views
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Case Report

Case Report
A favorable outcome of advanced dermatofibrosarcoma protuberans under treatment with sunitinib after imatinib failure
Wei Xiao, Yi Que, Ruiqing Peng, Ya Ding, Jingjing Zhao, Xizhi Wen, Desheng Weng, Xiaoshi Zhang, Yuanxiang Guan & Xing Zhang
Pages: 2439-2443
Published online: 14 Nov 2022
AbstractforA favorable outcome of advanced dermatofibrosarcoma protuberans under treatment with sunitinib after imatinib failure | Full Text | References | PDF (1.9 MB)
  • 73 Views
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Original Research

Article
The CXCL12 rs1801157 polymorphism and risk of colorectal cancer: a meta-analysis
Ke Xu, Hong Dai, Shaolong Wang, Jie Zhang & Tao Liu
Pages: 2445-2452
Published online: 01 May 2018
AbstractforThe CXCL12 rs1801157 polymorphism and risk of colorectal cancer: a meta-analysis | Full Text | References | PDF (727.8 KB)
  • 53 Views
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Article
Comprehensive analysis of a long noncoding RNA-associated competing endogenous RNA network in colorectal cancer
Qiaowei Fan & Bingrong Liu
Pages: 2453-2466
Published online: 14 Nov 2022
AbstractforComprehensive analysis of a long noncoding RNA-associated competing endogenous RNA network in colorectal cancer | Full Text | References | PDF (18.1 MB)
  • 96 Views
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Article
Rechallenge of oxaliplatin-containing regimens in the third- or later-line therapy for patients with heavily treated metastatic colorectal cancer
Qiong Yang, Yuanyuan Huang, Zhimin Jiang, Huizhong Wang, Weiyu Li, Bei Zhang & Derong Xie
Pages: 2467-2473
Published online: 14 Nov 2022
AbstractforRechallenge of oxaliplatin-containing regimens in the third- or later-line therapy for patients with heavily treated metastatic colorectal cancer | Full Text | References | PDF (860.9 KB)
  • 90 Views
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Article
UCA1 promotes cell proliferation and invasion and inhibits apoptosis through regulation of the miR129–SOX4 pathway in renal cell carcinoma
Qian Liu, Yang Li, Weiling Lv, Guangwei Zhang, Xin Tian, Xiaodong Li, Hepeng Cheng & Chaoyang Zhu
Pages: 2475-2487
Published online: 01 May 2018
AbstractforUCA1 promotes cell proliferation and invasion and inhibits apoptosis through regulation of the miR129–SOX4 pathway in renal cell carcinoma | Full Text | References | PDF (6.7 MB)
  • 72 Views
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Article
Pretreatment hematologic markers as prognostic predictors of gastroenteropancreatic neuroendocrine tumors: a systematic review and meta-analysis
Yu Zhou, Dezhi Li, Ye Lin, Min Yu, Xin Lu, Zhixiang Jian, Ning Na & Baohua Hou
Pages: 2489-2496
Published online: 01 May 2018
AbstractforPretreatment hematologic markers as prognostic predictors of gastroenteropancreatic neuroendocrine tumors: a systematic review and meta-analysis | Full Text | References | PDF (651.9 KB)
  • 74 Views
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Article
The genetic association between iNOS and eNOS polymorphisms and gastric cancer risk: a meta-analysis
Yi Zhu, Honggang Jiang, Zhiheng Chen, Bohao Lu, Jin Li, Yuping Peng & Xuning Shen
Pages: 2497-2507
Published online: 03 May 2018
AbstractforThe genetic association between iNOS and eNOS polymorphisms and gastric cancer risk: a meta-analysis | Full Text | References | PDF (1.1 MB)
  • 73 Views
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Article
Clinical and radiological characteristics of central pulmonary adenocarcinoma: a comparison with central squamous cell carcinoma and small cell lung cancer and the impact on treatment response
Zhe Wang, Minghuan Li, Yong Huang, Li Ma, Hui Zhu, Li Kong & Jinming Yu
Pages: 2509-2517
Published online: 04 May 2018
AbstractforClinical and radiological characteristics of central pulmonary adenocarcinoma: a comparison with central squamous cell carcinoma and small cell lung cancer and the impact on treatment response | Full Text | References | PDF (894 KB)
  • 88 Views
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Article
Low circulating total adiponectin, especially its non-high-molecular weight fraction, represents a promising risk factor for colorectal cancer: a meta-analysis
Weiqun Lu, Zhiliang Huang, Nan Li & Haiying Liu
Pages: 2519-2531
Published online: 04 May 2018
AbstractforLow circulating total adiponectin, especially its non-high-molecular weight fraction, represents a promising risk factor for colorectal cancer: a meta-analysis | Full Text | References | PDF (1.2 MB)
  • 63 Views
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Article
Prognostic factors for operable biliary tract cancer: serum levels of lactate dehydrogenase, a strong association with survival
Ling Ma, Jinrong Qiu, Yaodong Zhang, Tianzhu Qiu, Biao Wang, Wensen Chen, Xiao Li, Jing Sun, Ke Wang, Xiangcheng Li, Yanhong Gu, Yongqian Shu & Xiaofeng Chen
Pages: 2533-2543
Published online: 04 May 2018
AbstractforPrognostic factors for operable biliary tract cancer: serum levels of lactate dehydrogenase, a strong association with survival | Full Text | References | PDF (869.9 KB)
  • 73 Views
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Article
Patterns of local failures and suggestions for reduction of clinical target volume for nasopharyngeal carcinoma patients without cervical lymph node metastasis
Yujiao Li, Xiaomin Ou, Chunying Shen, Tingting Xu, Weiwei Li & Chaosu Hu
Pages: 2545-2555
Published online: 07 May 2018
AbstractforPatterns of local failures and suggestions for reduction of clinical target volume for nasopharyngeal carcinoma patients without cervical lymph node metastasis | Full Text | References | PDF (1.2 MB)
  • 73 Views
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Case Report

Case Report
Perioperative chemotherapy with pemetrexed and cisplatin for pulmonary large-cell neuroendocrine carcinoma: a case report and literature review
Hong Tang, Hongyan Wang, Shaoyan Xi, Chunyu He, Yuxi Chang, Qiming Wang & Yufeng Wu
Pages: 2557-2563
Published online: 07 May 2018
AbstractforPerioperative chemotherapy with pemetrexed and cisplatin for pulmonary large-cell neuroendocrine carcinoma: a case report and literature review | Full Text | References | PDF (2.5 MB)
  • 231 Views
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Case Series

Fatal hemoptysis in patients with advanced esophageal cancer treated with apatinib
Wei Wang, Lin Zhang, Yan Xie, Tianchang Zhen, Gongzhang Su & Qi Zang
Pages: 2565-2570
Published online: 07 May 2018
AbstractforFatal hemoptysis in patients with advanced esophageal cancer treated with apatinib | Full Text | References | PDF (7.5 MB)
  • 69 Views
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Original Research

Article
Partial stereotactic ablative boost radiotherapy in bulky non-small cell lung cancer: a retrospective study
Yun Bai, Xian-shu Gao, Shang-bin Qin, Jia-yan Chen, Meng-meng Su, Qing Liu, Xiu-bo Qin, Ming-wei Ma, Bo Zhao, Xiao-bin Gu, Mu Xie, Ming Cui, Xin Qi & Xiao-ying Li
Pages: 2571-2579
Published online: 08 May 2018
AbstractforPartial stereotactic ablative boost radiotherapy in bulky non-small cell lung cancer: a retrospective study | Full Text | References | PDF (5.4 MB)
  • 65 Views
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Article
WWC3 inhibits epithelial–mesenchymal transition of lung cancer by activating Hippo-YAP signaling
Qiang Han, Joachim Kremerskothen, Xuyong Lin, Xiupeng Zhang, Xuezhu Rong, Di Zhang & Enhua Wang
Pages: 2581-2591
Published online: 08 May 2018
AbstractforWWC3 inhibits epithelial–mesenchymal transition of lung cancer by activating Hippo-YAP signaling | Full Text | References | PDF (5.6 MB)
  • 82 Views
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Article
Chelerythrine induced cell death through ROS-dependent ER stress in human prostate cancer cells
Songjiang Wu, Yanying Yang, Feiping Li, Lifu Huang, Zihua Han, Guanfu Wang, Hongyuan Yu & Haiping Li
Pages: 2593-2601
Published online: 08 May 2018
AbstractforChelerythrine induced cell death through ROS-dependent ER stress in human prostate cancer cells | Full Text | References | PDF (2.4 MB)
  • 80 Views
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Article
A 5-serum miRNA panel for the early detection of colorectal cancer
Shaohua Guo, Jiajin Zhang, Baishi Wang, Bingdong Zhang, Xuning Wang, Liang Huang, Hongyi Liu & Baoqing Jia
Pages: 2603-2614
Published online: 08 May 2018
AbstractforA 5-serum miRNA panel for the early detection of colorectal cancer | Full Text | References | PDF (1.3 MB)
  • 101 Views
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Review

Review Article
Are ovarian cancer stem cells the target for innovative immunotherapy?
Liang Wang, Tianmin Xu & Manhua Cui
Pages: 2615-2626
Published online: 08 May 2018
AbstractforAre ovarian cancer stem cells the target for innovative immunotherapy? | Full Text | References | PDF (1.3 MB)
  • 99 Views
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Original Research

Article
Predicting initial margin status in breast cancer patients during breast-conserving surgery
Zihao Pan, Liling Zhu, Qian Li, Jianguo Lai, Jingwen Peng, Fengxi Su, Shunrong Li & Kai Chen
Pages: 2627-2635
Published online: 08 May 2018
AbstractforPredicting initial margin status in breast cancer patients during breast-conserving surgery | Full Text | References | PDF (602.6 KB)
  • 73 Views
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Article
The utilization of next-generation sequencing to detect somatic mutations and predict clinical prognosis of Chinese non-small cell lung cancer patients
Liming Cao, Long Long, Min Li, Huaping Yang, Pengbo Deng, Xinru Mao, Jianxing Xiang, Bing Li, Tengfei Zhang & Chengping Hu
Pages: 2637-2646
Published online: 14 Nov 2022
AbstractforThe utilization of next-generation sequencing to detect somatic mutations and predict clinical prognosis of Chinese non-small cell lung cancer patients | Full Text | References | PDF (2.5 MB)
  • 98 Views
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Article
Effect of first-line endocrine therapy in patients with hormone-sensitive advanced breast cancer: a network meta-analysis
Tingting Zhang, Fubin Feng, Wenge Zhao, Jinhui Tian, Yan Yao, Chao Zhou, Shengjie Dong, Congcong Wang, Chuanxin Zang, Qingliang Lv & Changgang Sun
Pages: 2647-2656
Published online: 08 May 2018
AbstractforEffect of first-line endocrine therapy in patients with hormone-sensitive advanced breast cancer: a network meta-analysis | Full Text | References | PDF (1.1 MB)
  • 77 Views
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Article
Influence of different ex vivo cell culture methods on the proliferation and anti-tumor activity of cytokine-induced killer cells from gastric cancer patients
Bin Shi, Aixia Sun & Xiaorui Zhang
Pages: 2657-2672
Published online: 08 May 2018
AbstractforInfluence of different ex vivo cell culture methods on the proliferation and anti-tumor activity of cytokine-induced killer cells from gastric cancer patients | Full Text | References | PDF (4.2 MB)
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Article
Delivery of bevacizumab by intracranial injection: assessment in glioma model
Yu-Xiao Liu, Wen-Jia Liu, Hui-Ru Zhang & Zhi-Wen Zhang
Pages: 2673-2683
Published online: 08 May 2018
AbstractforDelivery of bevacizumab by intracranial injection: assessment in glioma model | Full Text | References | PDF (4.8 MB)
  • 107 Views
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Article
Traditional Chinese medicine Astragalus polysaccharide enhanced antitumor effects of the angiogenesis inhibitor apatinib in pancreatic cancer cells on proliferation, invasiveness, and apoptosis
Jun Wu, Jing Wang, Qiang Su, Wei Ding, Teng Li, Junxian Yu & Bangwei Cao
Pages: 2685-2698
Published online: 09 May 2018
AbstractforTraditional Chinese medicine Astragalus polysaccharide enhanced antitumor effects of the angiogenesis inhibitor apatinib in pancreatic cancer cells on proliferation, invasiveness, and apoptosis | Full Text | References | PDF (2.3 MB)
  • 131 Views
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Article
Clinical relevance of lysyl oxidase-like 2 and functional mechanisms in glioma
Xiao-Guang Du & Mei-Jia Zhu
Pages: 2699-2708
Published online: 09 May 2018
AbstractforClinical relevance of lysyl oxidase-like 2 and functional mechanisms in glioma | Full Text | References | PDF (2.7 MB)
  • 65 Views
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Article
Association between NR5A2 and the risk of pancreatic cancer, especially among Caucasians: a meta-analysis of case–control studies
Qun Chen, Hao Yuan, Guo-Dong Shi, Yang Wu, Dong-Fang Liu, Yu-Ting Lin, Lei Chen, Wan-Li Ge, Kuirong Jiang & Yi Miao
Pages: 2709-2723
Published online: 09 May 2018
AbstractforAssociation between NR5A2 and the risk of pancreatic cancer, especially among Caucasians: a meta-analysis of case–control studies | Full Text | References | PDF (2 MB)
  • 64 Views
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Article
Association between angiogenesis and cytotoxic signatures in the tumor microenvironment of gastric cancer
Yi Feng, Ying Dai, Zhihua Gong, Jia-Nan Cheng, Longhui Zhang, Chengdu Sun, Xianghua Zeng, Qingzhu Jia & Bo Zhu
Pages: 2725-2733
Published online: 10 May 2018
AbstractforAssociation between angiogenesis and cytotoxic signatures in the tumor microenvironment of gastric cancer | Full Text | References | PDF (7.1 MB)
  • 68 Views
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Article
Aloperine executes antitumor effects through the induction of apoptosis and cell cycle arrest in prostate cancer in vitro and in vivo
Zhixin Ling, Han Guan, Zonghao You, Can Wang, Ling Hu, Lei Zhang, Yiduo Wang, Shuqiu Chen, Bin Xu & Ming Chen
Pages: 2735-2743
Published online: 11 May 2018
AbstractforAloperine executes antitumor effects through the induction of apoptosis and cell cycle arrest in prostate cancer in vitro and in vivo | Full Text | References | PDF (3.9 MB)
  • 96 Views
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Article
Leucine-rich alpha-2-glycoprotein-1 is up-regulated in colorectal cancer and is a tumor promoter
Qian Zhang, Rui Huang, Qingchao Tang, Yang Yu, Quanlong Huang, Yinggang Chen, Guiyu Wang & Xishan Wang
Pages: 2745-2752
Published online: 11 May 2018
AbstractforLeucine-rich alpha-2-glycoprotein-1 is up-regulated in colorectal cancer and is a tumor promoter | Full Text | References | PDF (917.9 KB)
  • 109 Views
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Article
Upregulation of circ_0066444 promotes the proliferation, invasion, and migration of gastric cancer cells
Dawei Rong, Chaoxi Dong, Kai Fu, Hanjin Wang, Weiwei Tang & Hongyong Cao
Pages: 2753-2761
Published online: 11 May 2018
AbstractforUpregulation of circ_0066444 promotes the proliferation, invasion, and migration of gastric cancer cells | Full Text | References | PDF (2 MB)
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Article
ZNF418 overexpression protects against gastric carcinoma and prompts a good prognosis
Hong-xia Hui, Zhong-wu Hu, Chao Jiang, Jian Wu, Yong Gao & Xiao-wei Wang
Pages: 2763-2770
Published online: 11 May 2018
AbstractforZNF418 overexpression protects against gastric carcinoma and prompts a good prognosis | Full Text | References | PDF (1.9 MB)
  • 56 Views
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Article
Peritoneal carcinomatosis index as a predictor of diaphragmatic involvement in stage III and IV ovarian cancer
Antoni Llueca, Anna Serra, José Luis Herraiz, Isabel Rivadulla, Luis Gomez-Quiles, Juan Gilabert-Estelles, Javier Escrig & On behalf of the MUAPOS (Multidisciplinary Unit of Abdominal Pelvic Oncology Surgery) working group
Pages: 2771-2777
Published online: 15 May 2018
AbstractforPeritoneal carcinomatosis index as a predictor of diaphragmatic involvement in stage III and IV ovarian cancer | Full Text | References | PDF (721.4 KB)
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Article
Impact of targeting transforming growth factor β-2 with antisense OT-101 on the cytokine and chemokine profile in patients with advanced pancreatic cancer
Osmond J D’Cruz, Sanjive Qazi, Larn Hwang, Kevin Ng & Vuong Trieu
Pages: 2779-2796
Published online: 14 Nov 2022
AbstractforImpact of targeting transforming growth factor β-2 with antisense OT-101 on the cytokine and chemokine profile in patients with advanced pancreatic cancer | Full Text | References | PDF (3.5 MB)
  • 79 Views
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Article
Long noncoding RNA GAPLINC promotes gastric cancer cell proliferation by acting as a molecular sponge of miR-378 to modulate MAPK1 expression
Lingyun Diao, Shengying Wang & Zhiguang Sun
Pages: 2797-2804
Published online: 14 Nov 2022
AbstractforLong noncoding RNA GAPLINC promotes gastric cancer cell proliferation by acting as a molecular sponge of miR-378 to modulate MAPK1 expression | Full Text | References | PDF (1.6 MB)
  • 75 Views
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Article
5-Azacytidine treatment induces demethylation of DAPK1 and MGMT genes and inhibits growth in canine mammary gland tumor cells
Xiaoli Ren, Huatao Li, Xianyi Song, Yuhong Wu & Yun Liu
Pages: 2805-2813
Published online: 15 May 2018
Abstractfor5-Azacytidine treatment induces demethylation of DAPK1 and MGMT genes and inhibits growth in canine mammary gland tumor cells | Full Text | References | PDF (2.3 MB)
  • 75 Views
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Article
Identifying miRNA and gene modules of colon cancer associated with pathological stage by weighted gene co-expression network analysis
Xian-guo Zhou, Xiao-liang Huang, Si-yuan Liang, Shao-mei Tang, Si-kao Wu, Tong-tong Huang, Zeng-nan Mo & Qiu-yan Wang
Pages: 2815-2830
Published online: 15 May 2018
AbstractforIdentifying miRNA and gene modules of colon cancer associated with pathological stage by weighted gene co-expression network analysis | Full Text | References | PDF (8.2 MB)
  • 241 Views
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Review

Review Article
Advances of exosome in the development of ovarian cancer and its diagnostic and therapeutic prospect
Jiayu Shen, Xiaoqing Zhu, Jing Fei, Pengyao Shi, Shuqian Yu & Jianwei Zhou
Pages: 2831-2841
Published online: 15 May 2018
AbstractforAdvances of exosome in the development of ovarian cancer and its diagnostic and therapeutic prospect | Full Text | References | PDF (514.7 KB)
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Original Research

Article
NDRG3 facilitates colorectal cancer metastasis through activating Src phosphorylation
Ting Li, Ruochuan Sun, Mingdian Lu, Jiacong Chang, Xiangling Meng & Huo Wu
Pages: 2843-2852
Published online: 15 May 2018
AbstractforNDRG3 facilitates colorectal cancer metastasis through activating Src phosphorylation | Full Text | References | PDF (12.9 MB)
  • 121 Views
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Article
circSMAD2 inhibits the epithelial–mesenchymal transition by targeting miR-629 in hepatocellular carcinoma
Xianwei Zhang, Ping Luo, Wei Jing, Hu Zhou, Chunzi Liang & Jiancheng Tu
Pages: 2853-2863
Published online: 16 May 2018
AbstractforcircSMAD2 inhibits the epithelial–mesenchymal transition by targeting miR-629 in hepatocellular carcinoma | Full Text | References | PDF (1.9 MB)
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Review

Review Article
Leaflet manual of external beam radiation therapy for hepatocellular carcinoma: a review of the indications, evidences, and clinical trials
Chai Hong Rim & Won Sup Yoon
Pages: 2865-2874
Published online: 16 May 2018
AbstractforLeaflet manual of external beam radiation therapy for hepatocellular carcinoma: a review of the indications, evidences, and clinical trials | Full Text | References | PDF (524.8 KB)
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Original Research

Article
RIP1 regulates TNF-α-mediated lymphangiogenesis and lymphatic metastasis in gallbladder cancer by modulating the NF-κB-VEGF-C pathway
Cheng-Zong Li, Xiao-Jie Jiang, Bin Lin, Hai-Jie Hong, Si-Yuan Zhu, Lei Jiang, Xiao-Qian Wang, Nan-Hong Tang, Fei-Fei She & Yan-Ling Chen
Pages: 2875-2890
Published online: 16 May 2018
AbstractforRIP1 regulates TNF-α-mediated lymphangiogenesis and lymphatic metastasis in gallbladder cancer by modulating the NF-κB-VEGF-C pathway | Full Text | References | PDF (8.4 MB)
  • 75 Views
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Article
Bacillus Calmette–Guérin and anti-PD-L1 combination therapy boosts immune response against bladder cancer
Yonghua Wang, Jing Liu, Xuecheng Yang, Yanan Liu, Yong Liu, Yanjiang Li, Lijiang Sun, Xiaokun Yang & Haitao Niu
Pages: 2891-2899
Published online: 14 Nov 2022
AbstractforBacillus Calmette–Guérin and anti-PD-L1 combination therapy boosts immune response against bladder cancer | Full Text | References | PDF (2.1 MB)
  • 128 Views
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Article
High neutrophil to lymphocyte ratio and decreased CD69+NK cells represent a phenotype of high risk in early-stage breast cancer patients
Pablo Mandó, Manglio Rizzo, María Paula Roberti, Estefanía Paula Juliá, María Betina Pampena, Constanza Pérez de la Puente, Carlos Martín Loza, Carolina Ponce, Jorge Nadal, Federico Andres Coló, José Mordoh & Estrella Mariel Levy
Pages: 2901-2910
Published online: 14 Nov 2022
AbstractforHigh neutrophil to lymphocyte ratio and decreased CD69+NK cells represent a phenotype of high risk in early-stage breast cancer patients | Full Text | References | PDF (1.5 MB)
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Article
miR-598 acts as a tumor suppressor in human gastric cancer by targeting IGF-1R
Na Liu, Hua Yang & Hong Wang
Pages: 2911-2923
Published online: 17 May 2018
AbstractformiR-598 acts as a tumor suppressor in human gastric cancer by targeting IGF-1R | Full Text | References | PDF (3.9 MB)
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Article
Downregulation of PDIA3 inhibits proliferation and invasion of human acute myeloid leukemia cells
Qidong Ye, Pan Fu, Jiaying Dou & Nina Wang
Pages: 2925-2935
Published online: 17 May 2018
AbstractforDownregulation of PDIA3 inhibits proliferation and invasion of human acute myeloid leukemia cells | Full Text | References | PDF (3.8 MB)
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Article
Indirubin inhibits cell proliferation, migration, invasion and angiogenesis in tumor-derived endothelial cells
Zhuohong Li, Chaofu Zhu, Baiping An, Yu Chen, Xiuyun He, Lin Qian, Lan Lan & Shijie Li
Pages: 2937-2944
Published online: 18 May 2018
AbstractforIndirubin inhibits cell proliferation, migration, invasion and angiogenesis in tumor-derived endothelial cells | Full Text | References | PDF (6.2 MB)
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Article
Triclosan treatment decreased the antitumor effect of sorafenib on hepatocellular carcinoma cells
Man Wu, Guanren Zhao, Xiaomei Zhuang, Tianhong Zhang, Ce Zhang, Wenpeng Zhang & Zhenqing Zhang
Pages: 2945-2954
Published online: 18 May 2018
AbstractforTriclosan treatment decreased the antitumor effect of sorafenib on hepatocellular carcinoma cells | Full Text | References | PDF (1.5 MB)
  • 72 Views
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Article
Downregulation of STARD8 in gastric cancer and its involvement in gastric cancer progression
Shuanglong Zhang, Xiaojing Chang, Jinguo Ma, Jing Chen, Yu Zhi, Zhenhua Li & Dongqiu Dai
Pages: 2955-2961
Published online: 21 May 2018
AbstractforDownregulation of STARD8 in gastric cancer and its involvement in gastric cancer progression | Full Text | References | PDF (1.9 MB)
  • 65 Views
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Article
Ovol2 induces mesenchymal–epithelial transition via targeting ZEB1 in osteosarcoma
Jijun Liu, Qi Wu, Yonggui Wang, Yulong Wei, Hong Wu, Lijun Duan, Qiang Zhang & Yonggang Wu
Pages: 2963-2973
Published online: 22 May 2018
AbstractforOvol2 induces mesenchymal–epithelial transition via targeting ZEB1 in osteosarcoma | Full Text | References | PDF (5.2 MB)
  • 86 Views
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Article
Intra-arterial chemotherapy improved survival of stage 2–3 gallbladder cancer after curative resection
Cheng Chen, Wenming Feng, Yinyuan Zheng, Ying Bao & Min Feng
Pages: 2975-2979
Published online: 22 May 2018
AbstractforIntra-arterial chemotherapy improved survival of stage 2–3 gallbladder cancer after curative resection | Full Text | References | PDF (832.2 KB)
  • 59 Views
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Article
Resveratrol inhibits the proliferation of A549 cells by inhibiting the expression of COX-2
Xia Li, Fang Li, Fangfang Wang, Jinfeng Li, Cunzhi Lin & Jianxin Du
Pages: 2981-2989
Published online: 22 May 2018
AbstractforResveratrol inhibits the proliferation of A549 cells by inhibiting the expression of COX-2 | Full Text | References | PDF (1.8 MB)
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Article
The methylation profiles of PRDM promoters in non–small cell lung cancer
Shuang-xiang Tan, Rui-cheng Hu, Qian Xia, Yong-li Tan, Jing-jing Liu, Gui-xiang Gan & Li-le Wang
Pages: 2991-3002
Published online: 22 May 2018
AbstractforThe methylation profiles of PRDM promoters in non–small cell lung cancer | Full Text | References | PDF (10.5 MB)
  • 95 Views
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Review

Review Article
The role of HIF-1α in chemo-/radioresistant tumors
Yu Xia, Lixia Jiang & Tianyu Zhong
Pages: 3003-3011
Published online: 14 Nov 2022
AbstractforThe role of HIF-1α in chemo-/radioresistant tumors | Full Text | References | PDF (268.4 KB)
  • 125 Views
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Original Research

Article
Expression of HSP90AA1/HSPA8 in hepatocellular carcinoma patients with depression
Xiao Xiang, Xue-Mei You & Le-Qun Li
Pages: 3013-3023
Published online: 22 May 2018
AbstractforExpression of HSP90AA1/HSPA8 in hepatocellular carcinoma patients with depression | Full Text | References | PDF (8.2 MB)
  • 116 Views
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Article
LGR6 promotes the progression of gastric cancer through PI3K/AKT/mTOR pathway
Jing Ke, Peng Ma, Jinpeng Chen, Jun Qin & Haixin Qian
Pages: 3025-3033
Published online: 22 May 2018
AbstractforLGR6 promotes the progression of gastric cancer through PI3K/AKT/mTOR pathway | Full Text | References | PDF (8.3 MB)
  • 82 Views
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Article
High expression of USP22 predicts poor prognosis and advanced clinicopathological features in solid tumors: a meta-analysis
Xiaohui Yang, Haiyang Zang, Yingbin Luo, Jianchun Wu, Zhihong Fang, Weikang Zhu & Yan Li
Pages: 3035-3046
Published online: 23 May 2018
AbstractforHigh expression of USP22 predicts poor prognosis and advanced clinicopathological features in solid tumors: a meta-analysis | Full Text | References | PDF (1 MB)
  • 69 Views
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Article
The synergistic effects of Apatinib combined with cytotoxic chemotherapeutic agents on gastric cancer cells and in a fluorescence imaging gastric cancer xenograft model
Jiuhuan Feng & Shukui Qin
Pages: 3047-3057
Published online: 24 May 2018
AbstractforThe synergistic effects of Apatinib combined with cytotoxic chemotherapeutic agents on gastric cancer cells and in a fluorescence imaging gastric cancer xenograft model | Full Text | References | PDF (3.4 MB)
  • 74 Views
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Article
Progression-free survival as a surrogate endpoint of overall survival in patients with metastatic colorectal cancer
Giuseppe Cicero, Rossella De Luca & Francesco Dieli
Pages: 3059-3063
Published online: 24 May 2018
AbstractforProgression-free survival as a surrogate endpoint of overall survival in patients with metastatic colorectal cancer | Full Text | References | PDF (664.2 KB)
  • 105 Views
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Article
Gene expression and prognosis of NOX family members in gastric cancer
Xin You, Mingzhe Ma, Guoxin Hou, Yumin Hu & Xi Shi
Pages: 3065-3074
Published online: 24 May 2018
AbstractforGene expression and prognosis of NOX family members in gastric cancer | Full Text | References | PDF (1.9 MB)
  • 111 Views
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Article
An integrated analysis of key microRNAs, regulatory pathways and clinical relevance in bladder cancer
Dongyang Li, Xuanyu Hao & Yongsheng Song
Pages: 3075-3085
Published online: 24 May 2018
AbstractforAn integrated analysis of key microRNAs, regulatory pathways and clinical relevance in bladder cancer | Full Text | References | PDF (3.5 MB)
  • 112 Views
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Article
Inhibition of survivin enhances radiosensitivity of esophageal cancer cells by switching radiation-induced senescence to apoptosis
Xianghe Liu, Yahui Zhao, Weina Zhang, Yang Gao, Miaomiao Huo, Mei Liu, Zefen Xiao, Shufang Liang, Ningzhi Xu & Hongxia Zhu
Pages: 3087-3100
Published online: 24 May 2018
AbstractforInhibition of survivin enhances radiosensitivity of esophageal cancer cells by switching radiation-induced senescence to apoptosis | Full Text | References | PDF (5.7 MB)
  • 71 Views
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Article
Downregulation of CPT2 promotes tumorigenesis and chemoresistance to cisplatin in hepatocellular carcinoma
Meihua Lin, Duo Lv, Yunliang Zheng, Minglan Wu, Chang Xu, Qiao Zhang & Lihua Wu
Pages: 3101-3110
Published online: 25 May 2018
AbstractforDownregulation of CPT2 promotes tumorigenesis and chemoresistance to cisplatin in hepatocellular carcinoma | Full Text | References | PDF (1 MB)
  • 115 Views
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Article
Overexpression of MCPH1 inhibits the migration and invasion of lung cancer cells
Xiaobin Wu, Wei Liu, Xueliang Liu, Qing Ai & Jialin Yu
Pages: 3111-3117
Published online: 25 May 2018
AbstractforOverexpression of MCPH1 inhibits the migration and invasion of lung cancer cells | Full Text | References | PDF (2 MB)
  • 67 Views
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Article
The incidence and predictors of symptomatic venous thromboembolism associated with peripherally inserted central catheters in patients with nasopharyngeal carcinoma
Yu-Jing Liang, Yan He, Jian-Mei Li, Lin-Min Chen, Li-Ping Chen, Cong Wang, Lu Ji, Zhen-Xiu Li, Lin-Quan Tang, Qiu-Yan Chen, Yu-Ying Fan & Wen Hu
Pages: 3119-3127
Published online: 25 May 2018
AbstractforThe incidence and predictors of symptomatic venous thromboembolism associated with peripherally inserted central catheters in patients with nasopharyngeal carcinoma | Full Text | References | PDF (636.4 KB)
  • 64 Views
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Article
Construction of a specific SVM classifier and identification of molecular markers for lung adenocarcinoma based on lncRNA-miRNA-mRNA network
Jingming Zhao, Wei Cheng, Xigang He, Yanli Liu, Ji Li, Jiaxing Sun, Jinfeng Li, Fangfang Wang & Yufang Gao
Pages: 3129-3140
Published online: 25 May 2018
AbstractforConstruction of a specific SVM classifier and identification of molecular markers for lung adenocarcinoma based on lncRNA-miRNA-mRNA network | Full Text | References | PDF (4.3 MB)
  • 87 Views
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Article
miR-134 increases the antitumor effects of cytarabine by targeting Mnks in acute myeloid leukemia cells
Kankan Chen, Yue Chen, Zhi Chen, Yuye Shi, Zhengmei He, Banghe Ding, Chunling Wang & Liang Yu
Pages: 3141-3147
Published online: 25 May 2018
AbstractformiR-134 increases the antitumor effects of cytarabine by targeting Mnks in acute myeloid leukemia cells | Full Text | References | PDF (3.1 MB)
  • 78 Views
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Article
High SRPX2 protein expression predicts unfavorable clinical outcome in patients with prostate cancer
Meng Zhang, Xiaoli Li, Zhirui Fan, Jing Zhao, Shuzheng Liu, Mingzhi Zhang, Huixiang Li, Mariusz Adam Goscinski, Huijie Fan & Zhenhe Suo
Pages: 3149-3157
Published online: 28 May 2018
AbstractforHigh SRPX2 protein expression predicts unfavorable clinical outcome in patients with prostate cancer | Full Text | References | PDF (2.1 MB)
  • 98 Views
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Article
CEACAM6 is associated with osteosarcoma metastasis and facilitates epithelial–mesenchymal transition in osteosarcoma cells
Zeyu Wang, Chong Luo, Huidan Wang, Xia Yan, Wei Liu & Zengdong Meng
Pages: 3159-3166
Published online: 28 May 2018
AbstractforCEACAM6 is associated with osteosarcoma metastasis and facilitates epithelial–mesenchymal transition in osteosarcoma cells | Full Text | References | PDF (3 MB)
  • 83 Views
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Review

Review Article
Recent advances on the progressive mechanism and therapy in castration-resistant prostate cancer
Keshan Wang, Hailong Ruan, Tianbo Xu, Lei Liu, Di Liu, Hongmei Yang, Xiaoping Zhang & Ke Chen
Pages: 3167-3178
Published online: 14 Nov 2022
AbstractforRecent advances on the progressive mechanism and therapy in castration-resistant prostate cancer | Full Text | References | PDF (424.1 KB)
  • 112 Views
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Case Report

Case Report
A large and aggressive fibromatosis in the axilla: a rare case report and review of the literature
Mingyue Duan, Hua Xing, Keren Wang, Chunbo Niu, Chengwei Jiang, Lijuan Zhang, Shereen Ezzat & Le Zhang
Pages: 3179-3184
Published online: 28 May 2018
AbstractforA large and aggressive fibromatosis in the axilla: a rare case report and review of the literature | Full Text | References | PDF (3.5 MB)
  • 77 Views
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Review

Review Article
Emerging role of long non-coding RNAs in cisplatin resistance
Yang Hu, Qiong-Ni Zhu, Jun-Li Deng, Zhi-Xing Li, Guo Wang & Yuan-Shan Zhu
Pages: 3185-3194
Published online: 28 May 2018
AbstractforEmerging role of long non-coding RNAs in cisplatin resistance | Full Text | References | PDF (498.3 KB)
  • 143 Views
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Original Research

Article
Knockdown of KIF26B inhibits breast cancer cell proliferation, migration, and invasion
Shudong Gu, Haibin Liang, Donghui Qi, Liyan Mao, Guoxin Mao, Li Qian & Shu Zhang
Pages: 3195-3203
Published online: 14 Nov 2022
AbstractforKnockdown of KIF26B inhibits breast cancer cell proliferation, migration, and invasion | Full Text | References | PDF (3.8 MB)
  • 91 Views
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Article
Periostin overexpression is associated with worse prognosis in nasopharyngeal carcinoma from endemic area: a cohort study
Yu-Ching Wei, Sheau-Fang Yang, Shih-Lun Chang, Tzu-Ju Chen, Sung-Wei Lee, Hung-Sung Chen, Li-Ching Lin & Chien-Feng Li
Pages: 3205-3213
Published online: 29 May 2018
AbstractforPeriostin overexpression is associated with worse prognosis in nasopharyngeal carcinoma from endemic area: a cohort study | Full Text | References | PDF (3.1 MB)
  • 56 Views
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Article
RETRACTED ARTICLE: Knockdown of long noncoding RNA 00152 (LINC00152) inhibits human retinoblastoma progression
Songhe Li, Dacheng Wen, Songtian Che, Zhihua Cui, Yabin Sun, Hua Ren & Jilong Hao
Pages: 3215-3223
Published online: 06 Jun 2018
AbstractforRETRACTED ARTICLE: Knockdown of long noncoding RNA 00152 (LINC00152) inhibits human retinoblastoma progression | PDF (1.5 MB)
  • 18 Views
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Article
Association between KIF1B (rs17401966) polymorphism and hepatocellular carcinoma susceptibility: a meta-analysis
Ya-fei Zhang, Xian-ling Zeng, Hong-wei Lu, Hong Ji, Le Lu, Peng-di Liu, Ruo-feng Hong & Yi-ming Li
Pages: 3225-3235
Published online: 29 May 2018
AbstractforAssociation between KIF1B (rs17401966) polymorphism and hepatocellular carcinoma susceptibility: a meta-analysis | Full Text | References | PDF (3.8 MB)
  • 64 Views
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Article
Prognostic significance of galectin-1 and vasculogenic mimicry in patients with gastric cancer
Xiaolan You, Yuanjie Wang, Jian Wu, Qinghong Liu, Dehu Chen, Dong Tang & Daorong Wang
Pages: 3237-3244
Published online: 14 Nov 2022
AbstractforPrognostic significance of galectin-1 and vasculogenic mimicry in patients with gastric cancer | Full Text | References | PDF (1 MB)
  • 72 Views
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Review

Review Article
Prognostic role of plasma mammaglobin A expression in breast carcinoma patients: a meta-analysis
Yuanyuan Hu, Peipei Liu, Di Wu & Youhong Jiang
Pages: 3245-3255
Published online: 14 Nov 2022
AbstractforPrognostic role of plasma mammaglobin A expression in breast carcinoma patients: a meta-analysis | Full Text | References | PDF (914.6 KB)
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Original Research

Article
A new apatinib microcrystal formulation enhances the effect of radiofrequency ablation treatment on hepatocellular carcinoma
Hui Xie, Shengtao Tian, Haipeng Yu, Xueling Yang, Jia Liu, Huaming Wang, Fan Feng & Zhi Guo
Pages: 3257-3265
Published online: 31 May 2018
AbstractforA new apatinib microcrystal formulation enhances the effect of radiofrequency ablation treatment on hepatocellular carcinoma | Full Text | References | PDF (2.1 MB)
  • 55 Views
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Article
Association of VDR gene TaqI polymorphism with the susceptibility to prostate cancer in Asian population evaluated by an updated systematic meta-analysis
Liangliang Chen, Junjun Wei, Shuwei Zhang, Zhongguan Lou, Xue Wang, Yu Ren, Honggang Qi, Zhenhua Xie, Yirun Chen, Feng Chen, Qihang Wu, Xiaoxiao Fan, Honglei Xu, Shuaishuai Huang & Guobin Weng
Pages: 3267-3280
Published online: 31 May 2018
AbstractforAssociation of VDR gene TaqI polymorphism with the susceptibility to prostate cancer in Asian population evaluated by an updated systematic meta-analysis | Full Text | References | PDF (2.1 MB)
  • 64 Views
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Article
Obesity-associated miR-27a upregulation promotes hepatocellular carcinoma metastasis through suppressing SFRP1
Yang Chen, Fan Zhang, Yawei Zhao, Kan He, Xiao Zheng, Yue Pan, Dan Shao, Pei Shang, Yongsheng Yang, Dan Zhang, Yingjun Xie, Xiaoxiao Yao, Li Chen, Jing Li & Xuewen Zhang
Pages: 3281-3292
Published online: 01 Jun 2018
AbstractforObesity-associated miR-27a upregulation promotes hepatocellular carcinoma metastasis through suppressing SFRP1 | Full Text | References | PDF (5.6 MB)
  • 88 Views
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Article
Effects of the combination of As2O3 and AZT on proliferation inhibition and apoptosis induction of hepatoma HepG2 cells following silencing of Egr-1
Chuan Zhao, Mei Wang, Yu Liu, Yongjuan Liang, Li Han & Che Chen
Pages: 3293-3301
Published online: 01 Jun 2018
AbstractforEffects of the combination of As2O3 and AZT on proliferation inhibition and apoptosis induction of hepatoma HepG2 cells following silencing of Egr-1 | Full Text | References | PDF (1.9 MB)
  • 53 Views
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Article
Overexpression of CLEC3A promotes tumor progression and poor prognosis in breast invasive ductal cancer
Jun Ni, Yun Peng, Fu-Lan Yang, Xun Xi, Xing-Wei Huang & Chun He
Pages: 3303-3312
Published online: 05 Jun 2018
AbstractforOverexpression of CLEC3A promotes tumor progression and poor prognosis in breast invasive ductal cancer | Full Text | References | PDF (1.9 MB)
  • 73 Views
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Article
Novel quinazoline-based sulfonamide derivative (3D) induces apoptosis in colorectal cancer by inhibiting JAK2–STAT3 pathway
Omar Al-Obeed, Mansoor-Ali Vaali-Mohammed, Wagdy M Eldehna, Khayal Al-Khayal, Amer Mahmood, Hatem A Abdel-Aziz, Ahmed Zubaidi, Ahmed Alafeefy, Maha Abdulla & Rehan Ahmad
Pages: 3313-3322
Published online: 05 Jun 2018
AbstractforNovel quinazoline-based sulfonamide derivative (3D) induces apoptosis in colorectal cancer by inhibiting JAK2–STAT3 pathway | Full Text | References | PDF (1.8 MB)
  • 84 Views
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Article
RETRACTED: Ablation of MCM10 using CRISPR/Cas9 restrains the growth and migration of esophageal squamous cell carcinoma cells through inhibition of Akt signaling
Jie Yan, Pan Du, Yongxu Jia, Zhiwei Chang, Silin Gan, Xiaohan Xu, Yaohe Wang, Yanru Qin & Quancheng Kan
Pages: 3323-3333
Published online: 06 Jun 2018
AbstractforRETRACTED: Ablation of MCM10 using CRISPR/Cas9 restrains the growth and migration of esophageal squamous cell carcinoma cells through inhibition of Akt signaling | PDF (3.7 MB)
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Article
Comparison of detection methods of EGFR T790M mutations using plasma, serum, and tumor tissue in EGFR-TKI-resistant non-small cell lung cancer
Keigo Kobayashi, Katsuhiko Naoki, Tadashi Manabe, Keita Masuzawa, Hanako Hasegawa, Hiroyuki Yasuda, Ichiro Kawada, Kenzo Soejima & Tomoko Betsuyaku
Pages: 3335-3343
Published online: 06 Jun 2018
AbstractforComparison of detection methods of EGFR T790M mutations using plasma, serum, and tumor tissue in EGFR-TKI-resistant non-small cell lung cancer | Full Text | References | PDF (2.8 MB)
  • 67 Views
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Article
Identification of PGAM1 as a putative therapeutic target for pancreatic ductal adenocarcinoma metastasis using quantitative proteomics
Xinlu Liu, Yejing Weng, Peng Liu, Zhigang Sui, Lei Zhou, Yinpeng Huang, Lihua Zhang, Yukui Zhang & Xiaodong Tan
Pages: 3345-3357
Published online: 06 Jun 2018
AbstractforIdentification of PGAM1 as a putative therapeutic target for pancreatic ductal adenocarcinoma metastasis using quantitative proteomics | Full Text | References | PDF (4.4 MB)
  • 109 Views
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Article
Effect of AQP-5 silencing by siRNA interference on chemosensitivity of breast cancer cells
Xueqing Li, Bing Pei, Hui Wang, Chenghui Tang, Wei Zhu & Feng Jin
Pages: 3359-3368
Published online: 06 Jun 2018
AbstractforEffect of AQP-5 silencing by siRNA interference on chemosensitivity of breast cancer cells | Full Text | References | PDF (1.9 MB)
  • 77 Views
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Article
Meta-analysis of segmentectomy versus wedge resection in stage IA non-small-cell lung cancer
Wenfei Xue, Guochen Duan, Xiaopeng Zhang, Hua Zhang, Qintao Zhao & Zhifei Xin
Pages: 3369-3375
Published online: 14 Nov 2022
AbstractforMeta-analysis of segmentectomy versus wedge resection in stage IA non-small-cell lung cancer | Full Text | References | PDF (710.8 KB)
  • 90 Views
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Article
Prognostic value of spleen tyrosine kinase in human solid tumors
Beibei Ni, Shi Li, Yang Liu, Yuqian Huang & Zesong Li
Pages: 3377-3384
Published online: 08 Jun 2018
AbstractforPrognostic value of spleen tyrosine kinase in human solid tumors | Full Text | References | PDF (933.9 KB)
  • 41 Views
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Article
Expression and functional characterization of FOXM1 in non-small cell lung cancer
Yan Zhang, Wen-bin Qiao & Li Shan
Pages: 3385-3393
Published online: 11 Jun 2018
AbstractforExpression and functional characterization of FOXM1 in non-small cell lung cancer | Full Text | References | PDF (1.7 MB)
  • 64 Views
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Review

Review Article
Sirtuin-4 (SIRT4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer
Guoyu Huang & Guanbao Zhu
Pages: 3395-3400
Published online: 11 Jun 2018
AbstractforSirtuin-4 (SIRT4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer | Full Text | References | PDF (238.5 KB)
  • 90 Views
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Original Research

Article
Identification of CD24 as a marker for tumorigenesis of melanoma
Ming-Rui Tang, Jia-Yan Guo, Di Wang & Nan Xu
Pages: 3401-3406
Published online: 12 Jun 2018
AbstractforIdentification of CD24 as a marker for tumorigenesis of melanoma | Full Text | References | PDF (1.5 MB)
  • 102 Views
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Article
Efficacy and safety of sorafenib versus apatinib in the treatment of intermediate and advanced hepatocellular carcinoma: a comparative retrospective study
Yizhuo Wang, Qing Gou, Rongde Xu, Xiaoming Chen & Zejian Zhou
Pages: 3407-3413
Published online: 12 Jun 2018
AbstractforEfficacy and safety of sorafenib versus apatinib in the treatment of intermediate and advanced hepatocellular carcinoma: a comparative retrospective study | Full Text | References | PDF (353.7 KB)
  • 98 Views
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Article
Twenty-gene-based prognostic model predicts lung adenocarcinoma survival
Kai Zhao, Zulei Li & Hui Tian
Pages: 3415-3424
Published online: 12 Jun 2018
AbstractforTwenty-gene-based prognostic model predicts lung adenocarcinoma survival | Full Text | References | PDF (2.9 MB)
  • 127 Views
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Review

Review Article
Reformulating acute myeloid leukemia: liposomal cytarabine and daunorubicin (CPX-351) as an emerging therapy for secondary AML
Evan C Chen, Amir T Fathi & Andrew M Brunner
Pages: 3425-3434
Published online: 12 Jun 2018
AbstractforReformulating acute myeloid leukemia: liposomal cytarabine and daunorubicin (CPX-351) as an emerging therapy for secondary AML | Full Text | References | PDF (374.2 KB)
  • 187 Views
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Original Research

Article
Effectiveness of lomustine and bevacizumab in progressive glioblastoma: a meta-analysis
Jie Song, Yue-Qin Xue, Ming-Ming Zhao & Peng Xu
Pages: 3435-3439
Published online: 14 Nov 2022
AbstractforEffectiveness of lomustine and bevacizumab in progressive glioblastoma: a meta-analysis | Full Text | References | PDF (429.8 KB)
  • 181 Views
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Article
Comparison of the prognosis of neoadjuvant chemoradiotherapy treatment with surgery alone in esophageal carcinoma: a meta-analysis
Hai-Feng Ma, Guo-Xiao Lv, Zhong-Fang Cai & Da-Hai Zhang
Pages: 3441-3447
Published online: 14 Jun 2018
AbstractforComparison of the prognosis of neoadjuvant chemoradiotherapy treatment with surgery alone in esophageal carcinoma: a meta-analysis | Full Text | References | PDF (722 KB)
  • 52 Views
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Article
The association of pretreatment serum albumin with outcomes in bladder cancer: a meta-analysis
Jialin Li, Yusheng Cheng, Guanghua Liu & Zhigang Ji
Pages: 3449-3459
Published online: 14 Nov 2022
AbstractforThe association of pretreatment serum albumin with outcomes in bladder cancer: a meta-analysis | Full Text | References | PDF (1.4 MB)
  • 54 Views
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Article
MALAT1 silencing suppresses prostate cancer progression by upregulating miR-1 and downregulating KRAS
Junkai Chang, Weibo Xu, Xinyi Du & Junqing Hou
Pages: 3461-3473
Published online: 15 Jun 2018
AbstractforMALAT1 silencing suppresses prostate cancer progression by upregulating miR-1 and downregulating KRAS | Full Text | References | PDF (2 MB)
  • 88 Views
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Article
STAT3 induces colorectal carcinoma progression through a novel miR-572-MOAP-1 pathway
Nan Wang, Xianli He, Ru Zhou, Guozhan Jia & Qing Qiao
Pages: 3475-3484
Published online: 14 Nov 2022
AbstractforSTAT3 induces colorectal carcinoma progression through a novel miR-572-MOAP-1 pathway | Full Text | References | PDF (1.6 MB)
  • 63 Views
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Article
RETRACTED ARTICLE: Downregulation of ribophorin II suppresses tumor growth, migration, and invasion of nasopharyngeal carcinoma
Feilong Hong, Yong Li, Haifeng Ni & Jing Li
Pages: 3485-3494
Published online: 15 Jun 2018
AbstractforRETRACTED ARTICLE: Downregulation of ribophorin II suppresses tumor growth, migration, and invasion of nasopharyngeal carcinoma | PDF (2.6 MB)
  • 41 Views
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Article
Association between common polymorphisms in ERCC gene and prognosis of osteosarcoma in patients treated with chemotherapy: a meta-analysis
Chunpu Li, Xin Yu, Dongmei Guo, Guanhua Liu, Kaigang Zhang, Qingliang Teng & Hai Lin
Pages: 3495-3504
Published online: 18 Jun 2018
AbstractforAssociation between common polymorphisms in ERCC gene and prognosis of osteosarcoma in patients treated with chemotherapy: a meta-analysis | Full Text | References | PDF (540 KB)
  • 71 Views
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Review

Review Article
Combined small-cell lung carcinoma
Jing Qin & Hongyang Lu
Pages: 3505-3511
Published online: 19 Jun 2018
AbstractforCombined small-cell lung carcinoma | Full Text | References | PDF (252.8 KB)
  • 186 Views
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Original Research

Article
The prognosis for patients with newly diagnosed glioblastoma receiving bevacizumab combination therapy: a meta-analysis
Ke-Li Liao, Song Huang & Yu-Peng Wu
Pages: 3513-3520
Published online: 19 Jun 2018
AbstractforThe prognosis for patients with newly diagnosed glioblastoma receiving bevacizumab combination therapy: a meta-analysis | Full Text | References | PDF (827.7 KB)
  • 60 Views
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Article
Curcumin suppresses the progression of laryngeal squamous cell carcinoma through the upregulation of miR-145 and inhibition of the PI3K/Akt/mTOR pathway
Xiaofeng Zhu & Ronghua Zhu
Pages: 3521-3531
Published online: 19 Jun 2018
AbstractforCurcumin suppresses the progression of laryngeal squamous cell carcinoma through the upregulation of miR-145 and inhibition of the PI3K/Akt/mTOR pathway | Full Text | References | PDF (2.4 MB)
  • 92 Views
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Review Article
Multiple biological functions of transcription factor 21 in the development of various cancers
Xiaodi Jiang & Zhi Yang
Pages: 3533-3539
Published online: 14 Nov 2022
AbstractforMultiple biological functions of transcription factor 21 in the development of various cancers | Full Text | References | PDF (1.9 MB)
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Article
Prognostic value of miR-17-5p in cancers: a meta-analysis
Weihao Kong, Yusheng Cheng, Hao Liang, Qiangxing Chen, Cuicui Xiao, Kun Li, Zenan Huang & Jian Zhang
Pages: 3541-3549
Published online: 19 Jun 2018
AbstractforPrognostic value of miR-17-5p in cancers: a meta-analysis | Full Text | References | PDF (657.4 KB)
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Article
The role of radioactive iodine therapy in papillary thyroid cancer: an observational study based on SEER
Jianing Tang, Deguang Kong, Qiuxia Cui, Kun Wang, Dan Zhang, Xing Liao, Yan Gong & Gaosong Wu
Pages: 3551-3560
Published online: 19 Jun 2018
AbstractforThe role of radioactive iodine therapy in papillary thyroid cancer: an observational study based on SEER | Full Text | References | PDF (1.3 MB)
  • 152 Views
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Article
Clinicopathological and prognostic significance of FoxM1 in hepatocellular carcinoma patients: a meta-analysis
Chaojie Liang, Jingyang Zhao, Hua Ge, Guangming Li & Jixiang Wu
Pages: 3561-3571
Published online: 14 Nov 2022
AbstractforClinicopathological and prognostic significance of FoxM1 in hepatocellular carcinoma patients: a meta-analysis | Full Text | References | PDF (3.3 MB)
  • 52 Views
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Article
Impact of RNA integrity and blood sample storage conditions on the gene expression analysis
Yanting Shen, Rui Li, Fei Tian, Zhenzhu Chen, Na Lu, Yunfei Bai, Qinyu Ge & Zuhong Lu
Pages: 3573-3581
Published online: 14 Nov 2022
AbstractforImpact of RNA integrity and blood sample storage conditions on the gene expression analysis | Full Text | References | PDF (1.6 MB)
  • 252 Views
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Article
lncRNA H19 predicts poor prognosis in patients with melanoma and regulates cell growth, invasion, migration and epithelial–mesenchymal transition in melanoma cells
Gaofeng Shi, Hu Li, Fengshan Gao & Qian Tan
Pages: 3583-3595
Published online: 20 Jun 2018
AbstractforlncRNA H19 predicts poor prognosis in patients with melanoma and regulates cell growth, invasion, migration and epithelial–mesenchymal transition in melanoma cells | Full Text | References | PDF (2.8 MB)
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Article
Whole-body MRI versus 18F-FDG PET/CT for pretherapeutic assessment and staging of lymphoma: a meta-analysis
Danyang Wang, Yanlei Huo, Suyun Chen, Hui Wang, Yingli Ding, Xiaochun Zhu & Chao Ma
Pages: 3597-3608
Published online: 20 Jun 2018
AbstractforWhole-body MRI versus 18F-FDG PET/CT for pretherapeutic assessment and staging of lymphoma: a meta-analysis | Full Text | References | PDF (1.1 MB)
  • 117 Views
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Article
A small compound spindlactone A sensitizes human endometrial cancer cells to TRAIL-induced apoptosis via the inhibition of NAD(P)H dehydrogenase quinone 1
Xiang-Zhai Zhao & Xiao-Hua Wu
Pages: 3609-3617
Published online: 21 Jun 2018
AbstractforA small compound spindlactone A sensitizes human endometrial cancer cells to TRAIL-induced apoptosis via the inhibition of NAD(P)H dehydrogenase quinone 1 | Full Text | References | PDF (1 MB)
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Article
RETRACTED ARTICLE: MYO5A inhibition by miR-145 acts as a predictive marker of occult neck lymph node metastasis in human laryngeal squamous cell carcinoma
Xudong Zhao, Wei Zhang & Wenyue Ji
Pages: 3619-3635
Published online: 21 Jun 2018
AbstractforRETRACTED ARTICLE: MYO5A inhibition by miR-145 acts as a predictive marker of occult neck lymph node metastasis in human laryngeal squamous cell carcinoma | PDF (3 MB)
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Article
TRIM44, a crucial target of miR-410, functions as a potential oncogene in osteosarcoma
Heng Wang, Zi-Ling Fang, Gong-Hao Zhang & Xin Ma
Pages: 3637-3647
Published online: 21 Jun 2018
AbstractforTRIM44, a crucial target of miR-410, functions as a potential oncogene in osteosarcoma | Full Text | References | PDF (7.4 MB)
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Article
lincROR influences the stemness and crizotinib resistance in EML–ALK+ non-small-cell lung cancer cells
Yonghua Yang, Jingyu Huang, Nianlin Xie, Hu Huang, Shaogan Xu, Jun Cai & Shuai Qi
Pages: 3649-3657
Published online: 22 Jun 2018
AbstractforlincROR influences the stemness and crizotinib resistance in EML–ALK+ non-small-cell lung cancer cells | Full Text | References | PDF (2.2 MB)
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Article
Prognostic impact of the number of lymph nodes examined in different stages of colorectal mucinous adenocarcinoma
Yong Ma, Yiqian Luo, Nan Lin, Yongzhu Lv, Yang Zhou, Bing Li, Kunna Han, Song Jiang & Jianjun Gao
Pages: 3659-3670
Published online: 25 Jun 2018
AbstractforPrognostic impact of the number of lymph nodes examined in different stages of colorectal mucinous adenocarcinoma | Full Text | References | PDF (951.8 KB)
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Article
CAT3, a prodrug of 13a(S)-3-hydroxyl-6,7-dimethoxyphenanthro[9,10-b]-indolizidine, circumvents temozolomide-resistant glioblastoma via the Hedgehog signaling pathway, independently of O6-methylguanine DNA methyltransferase expression
Ming Ji, Liyuan Wang, Ju Chen, Nina Xue, Chunyang Wang, Fangfang Lai, Rubing Wang, Shishan Yu, Jing Jin & Xiaoguang Chen
Pages: 3671-3684
Published online: 25 Jun 2018
AbstractforCAT3, a prodrug of 13a(S)-3-hydroxyl-6,7-dimethoxyphenanthro[9,10-b]-indolizidine, circumvents temozolomide-resistant glioblastoma via the Hedgehog signaling pathway, independently of O6-methylguanine DNA methyltransferase expression | Full Text | References | PDF (3.9 MB)
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Case Report

Case Report
An uncommon granulocytic sarcoma of the breast: a case report and literature review
Jie Zhai, Xiangyi Kong, Xue Yang, Jidong Gao, Lixue Xuan, Xiang Wang, Jing Wang & Yi Fang
Pages: 3685-3690
Published online: 25 Jun 2018
AbstractforAn uncommon granulocytic sarcoma of the breast: a case report and literature review | Full Text | References | PDF (3.5 MB)
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Article
Impact of smoking on efficacy of PD-1/PD-L1 inhibitors in non-small cell lung cancer patients: a meta-analysis
Bingjia Li, Xiaoyu Huang & Linlin Fu
Pages: 3691-3696
Published online: 26 Jun 2018
AbstractforImpact of smoking on efficacy of PD-1/PD-L1 inhibitors in non-small cell lung cancer patients: a meta-analysis | Full Text | References | PDF (719.4 KB)
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Article
Chemotherapy with or without pemetrexed as second-line regimens for advanced non-small-cell lung cancer patients who have progressed after first-line EGFR TKIs: a systematic review and meta-analysis
Zhihua Li, Haiyan Guo, Yiyu Lu, Jianxin Hu, Haitao Luo & Weiguang Gu
Pages: 3697-3703
Published online: 27 Jun 2018
AbstractforChemotherapy with or without pemetrexed as second-line regimens for advanced non-small-cell lung cancer patients who have progressed after first-line EGFR TKIs: a systematic review and meta-analysis | Full Text | References | PDF (559.4 KB)
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Case Report

Case Report
Targeted therapy and immunotherapy for platinum-refractory advanced ovarian adenosquamous carcinoma: a case report
Anji Li, Shuai Sun, Tao Song, Xi Li, Wen Cheng, Ruipin Yao, Danying Zhang, Zailong Cai, Jie Zhang, Dongxia Zhai & Chaoqin Yu
Pages: 3705-3711
Published online: 14 Nov 2022
AbstractforTargeted therapy and immunotherapy for platinum-refractory advanced ovarian adenosquamous carcinoma: a case report | Full Text | References | PDF (4.1 MB)
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Review

Review Article
Updates on the clinical diagnosis and management of ocular sebaceous carcinoma: a brief review of the literature
Yangfan Xu, Fang Li, Renbing Jia & Xianqun Fan
Pages: 3713-3720
Published online: 14 Nov 2022
AbstractforUpdates on the clinical diagnosis and management of ocular sebaceous carcinoma: a brief review of the literature | Full Text | References | PDF (243.5 KB)
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Article
Nuclear factor-κB p65 regulates glutaminase 1 expression in human hepatocellular carcinoma
Meng Dong, Lin Miao, Fengmei Zhang, Shengshui Li, Jingzhi Han, Ruohui Yu & Shuo Qie
Pages: 3721-3729
Published online: 28 Jun 2018
AbstractforNuclear factor-κB p65 regulates glutaminase 1 expression in human hepatocellular carcinoma | Full Text | References | PDF (2.5 MB)
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Review

Review Article
IRX-2 natural cytokine biologic for immunotherapy in patients with head and neck cancers
Gregory T Wolf, Jeffrey S Moyer, Michael J Kaplan, Jason G Newman, James E Egan, Neil L Berinstein & Theresa L Whiteside
Pages: 3731-3746
Published online: 28 Jun 2018
AbstractforIRX-2 natural cytokine biologic for immunotherapy in patients with head and neck cancers | Full Text | References | PDF (1.2 MB)
  • 105 Views
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Review Article
Primary effusion lymphoma: current perspectives
Mayur Narkhede, Shagun Arora & Chaitra Ujjani
Pages: 3747-3754
Published online: 28 Jun 2018
AbstractforPrimary effusion lymphoma: current perspectives | Full Text | References | PDF (242.2 KB)
  • 215 Views
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Review Article
Colorectal neoplasia differentially expressed: a long noncoding RNA with an imperative role in cancer
Meiyu Dai, Shan Li & Xue Qin
Pages: 3755-3763
Published online: 29 Jun 2018
AbstractforColorectal neoplasia differentially expressed: a long noncoding RNA with an imperative role in cancer | Full Text | References | PDF (1.3 MB)
  • 65 Views
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Article
Angiogenesis and vasculogenic mimicry are inhibited by 8-Br-cAMP through activation of the cAMP/PKA pathway in colorectal cancer
Sen Wang, Zhiyuan Zhang, Wenwei Qian, Dongjian Ji, Qingyuan Wang, Bing Ji, Yue Zhang, Chuan Zhang, Ye Sun, Chunyan Zhu & Yueming Sun
Pages: 3765-3774
Published online: 02 Jul 2018
AbstractforAngiogenesis and vasculogenic mimicry are inhibited by 8-Br-cAMP through activation of the cAMP/PKA pathway in colorectal cancer | Full Text | References | PDF (3.3 MB)
  • 93 Views
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Article
SIL1 functions as an oncogene in glioma by AKT/mTOR signaling pathway
Hao Xu, Shangchen Xu, Rui Zhang, Tao Xin & Qi Pang
Pages: 3775-3783
Published online: 02 Jul 2018
AbstractforSIL1 functions as an oncogene in glioma by AKT/mTOR signaling pathway | Full Text | References | PDF (5.5 MB)
  • 51 Views
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Article
A prospective study on neoadjuvant chemoradiotherapy plus anti-EGFR monoclonal antibody followed by surgery for locally advanced cervical cancer
Heming Lu, Yuying Wu, Xu Liu, Hailan Jiang, Qiang Pang, Luxing Peng, Jinjian Cheng, Shan Deng, Junzhao Gu, Renfeng Zhao, Xiaoxia Hu, Changyi Chen & Jinming Yu
Pages: 3785-3792
Published online: 02 Jul 2018
AbstractforA prospective study on neoadjuvant chemoradiotherapy plus anti-EGFR monoclonal antibody followed by surgery for locally advanced cervical cancer | Full Text | References | PDF (612.7 KB)
  • 87 Views
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Article
By blocking hexokinase-2 phosphorylation, limonin suppresses tumor glycolysis and induces cell apoptosis in hepatocellular carcinoma
Junliang Yao, Jingtian Liu & Wensheng Zhao
Pages: 3793-3803
Published online: 03 Jul 2018
AbstractforBy blocking hexokinase-2 phosphorylation, limonin suppresses tumor glycolysis and induces cell apoptosis in hepatocellular carcinoma | Full Text | References | PDF (2.2 MB)
  • 88 Views
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Article
Silencing of c-jun decreases cell migration, invasion, and EMT in radioresistant human nasopharyngeal carcinoma cell line CNE-2R
Guoxiang Lin, Binbin Yu, Zhongguo Liang, Ling Li, Song Qu, Kaihua Chen, Lei Zhou, Qiteng Lu, Yongchu Sun & Xiaodong Zhu
Pages: 3805-3815
Published online: 14 Nov 2022
AbstractforSilencing of c-jun decreases cell migration, invasion, and EMT in radioresistant human nasopharyngeal carcinoma cell line CNE-2R | Full Text | References | PDF (12.1 MB)
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Review

Review Article
Tumor-associated macrophage-derived cytokines enhance cancer stem-like characteristics through epithelial–mesenchymal transition
Yongxu Chen, Wei Tan & Changjun Wang
Pages: 3817-3826
Published online: 04 Jul 2018
AbstractforTumor-associated macrophage-derived cytokines enhance cancer stem-like characteristics through epithelial–mesenchymal transition | Full Text | References | PDF (2 MB)
  • 421 Views
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Article
Overexpression of Beclin1 inhibits proliferation and promotes apoptosis of human laryngeal squamous carcinoma cell Hep-2
Baoluo Wan, Yanzi Zang & Lin Wang
Pages: 3827-3833
Published online: 04 Jul 2018
AbstractforOverexpression of Beclin1 inhibits proliferation and promotes apoptosis of human laryngeal squamous carcinoma cell Hep-2 | Full Text | References | PDF (1.2 MB)
  • 61 Views
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Article
miR-106b-5p inhibits the invasion and metastasis of colorectal cancer by targeting CTSA
Shujuan Ni, Weiwei Weng, Midie Xu, Qifeng Wang, Cong Tan, Hui Sun, Lei Wang, Dan Huang, Xiang Du & Weiqi Sheng
Pages: 3835-3845
Published online: 04 Jul 2018
AbstractformiR-106b-5p inhibits the invasion and metastasis of colorectal cancer by targeting CTSA | Full Text | References | PDF (3.1 MB)
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Review

Review Article
The role of histone lysine methyltransferase NSD3 in cancer
Xu Han, Lianhua Piao, Qianfeng Zhuang, Xiaofeng Yuan, Zhiwei Liu & Xiaozhou He
Pages: 3847-3852
Published online: 05 Jul 2018
AbstractforThe role of histone lysine methyltransferase NSD3 in cancer | Full Text | References | PDF (347 KB)
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Article
Loss of miR-516a-3p mediates upregulation of ABCC5 in prostate cancer and drives its progression
Hongtuan Zhang, Zhenpeng Lian, Guangyu Sun, Ranlu Liu & Yong Xu
Pages: 3853-3867
Published online: 06 Jul 2018
AbstractforLoss of miR-516a-3p mediates upregulation of ABCC5 in prostate cancer and drives its progression | Full Text | References | PDF (3.6 MB)
  • 64 Views
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Article
Bortezomib-based therapy for transplant-ineligible East Asian patients with newly diagnosed mantle-cell lymphoma
Jie Jin, Rumiko Okamoto, Sung-Soo Yoon, Lee-Yung Shih, Jun Zhu, Ting Liu, Xiaonan Hong, Lixia Pei, Brendan Rooney, Helgi van de Velde & Huiqiang Huang
Pages: 3869-3882
Published online: 06 Jul 2018
AbstractforBortezomib-based therapy for transplant-ineligible East Asian patients with newly diagnosed mantle-cell lymphoma | Full Text | References | PDF (1.6 MB)
  • 57 Views
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Article
The clinical usefulness of natural killer cell activity in patients with suspected or diagnosed prostate cancer: an observational cross-sectional study
Wan Song, Ji Woong Yu, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Han Yong Choi, Eun-Suk Kang & Hwang Gyun Jeon
Pages: 3883-3889
Published online: 06 Jul 2018
AbstractforThe clinical usefulness of natural killer cell activity in patients with suspected or diagnosed prostate cancer: an observational cross-sectional study | Full Text | References | PDF (470.5 KB)
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Review

Review Article
MicroRNAs as potential biomarkers for diagnosis, therapy and prognosis of gastric cancer
Hai-Liang Yuan, Ting Wang & Kun-He Zhang
Pages: 3891-3900
Published online: 06 Jul 2018
AbstractforMicroRNAs as potential biomarkers for diagnosis, therapy and prognosis of gastric cancer | Full Text | References | PDF (351.1 KB)
  • 199 Views
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Article
Predictive value of single nucleotide polymorphisms in XRCC1 for radiation-induced normal tissue toxicity
Jing Zhao, Zheng Zhi, Ming Zhang, Qingxia Li, Jing Li, Xiao Wang & Chunling Ma
Pages: 3901-3918
Published online: 06 Jul 2018
AbstractforPredictive value of single nucleotide polymorphisms in XRCC1 for radiation-induced normal tissue toxicity | Full Text | References | PDF (1.2 MB)
  • 90 Views
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Article
Integrated omics and gene expression analysis identifies the loss of metabolite–metabolite correlations in small cell lung cancer
Li Yu, Kefeng Li, Zhaoguo Xu, Guoyuan Cui & Xiaoye Zhang
Pages: 3919-3929
Published online: 14 Nov 2022
AbstractforIntegrated omics and gene expression analysis identifies the loss of metabolite–metabolite correlations in small cell lung cancer | Full Text | References | PDF (2.4 MB)
  • 98 Views
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Article
Overexpression of DJ-1 correlates with aggressive clinicopathological characteristics and poor prognosis in malignant tumors: a meta-analysis
Qingting Wang, Fangwei Li, Wenhua Shi, Qianqian Zhang, Jian Wang, Xin Yan, Limin Chai & Manxiang Li
Pages: 3931-3942
Published online: 09 Jul 2018
AbstractforOverexpression of DJ-1 correlates with aggressive clinicopathological characteristics and poor prognosis in malignant tumors: a meta-analysis | Full Text | References | PDF (1.7 MB)
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Case Report

Case Report
Role of chemotherapy with epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) rechallenge in small cell transformation after EGFR-TKI failure: a case report
Sanghun Lee, Jeonghyun Joo, Minah Kwak, Kicheul Sohn & Songha Chon
Pages: 3943-3947
Published online: 14 Nov 2022
AbstractforRole of chemotherapy with epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) rechallenge in small cell transformation after EGFR-TKI failure: a case report | Full Text | References | PDF (2.5 MB)
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Article
Immunohistochemical expression of hormone receptors, Ki-67, endoglin (CD105), claudins 3 and 4, MMP-2 and -9 in endometrial polyps and endometrial cancer type I
Gustavo Filipov Peres, Daniel Spadoto-Dias, Flávia Neves Bueloni-Dias, Nilton José Leite, Leonardo Vieira Elias, Maria Aparecida Custódio Domingues, Carlos Roberto Padovani & Rogério Dias
Pages: 3949-3958
Published online: 09 Jul 2018
AbstractforImmunohistochemical expression of hormone receptors, Ki-67, endoglin (CD105), claudins 3 and 4, MMP-2 and -9 in endometrial polyps and endometrial cancer type I | Full Text | References | PDF (3.1 MB)
  • 100 Views
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Article
SIRT4 acts as a tumor suppressor in gastric cancer by inhibiting cell proliferation, migration, and invasion
Hongjie Sun, Dongli Huang, Guozheng Liu, Fengguo Jian, Jianfang Zhu & Lixia Zhang
Pages: 3959-3968
Published online: 10 Jul 2018
AbstractforSIRT4 acts as a tumor suppressor in gastric cancer by inhibiting cell proliferation, migration, and invasion | Full Text | References | PDF (2.6 MB)
  • 76 Views
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Article
Increased expression of antisense lncRNA SPINT1-AS1 predicts a poor prognosis in colorectal cancer and is negatively correlated with its sense transcript
Chen Li, Wei Li, Yanli Zhang, Xin Zhang, Tong Liu, Yi Zhang, Yongmei Yang, Lili Wang, Hongwei Pan, Jian Ji & Chuanxin Wang
Pages: 3969-3978
Published online: 10 Jul 2018
AbstractforIncreased expression of antisense lncRNA SPINT1-AS1 predicts a poor prognosis in colorectal cancer and is negatively correlated with its sense transcript | Full Text | References | PDF (1.4 MB)
  • 91 Views
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Article
Overexpressed CDR1as functions as an oncogene to promote the tumor progression via miR-7 in non-small-cell lung cancer
Xiaofei Zhang, Danfen Yang & Yaqiang Wei
Pages: 3979-3987
Published online: 10 Jul 2018
AbstractforOverexpressed CDR1as functions as an oncogene to promote the tumor progression via miR-7 in non-small-cell lung cancer | Full Text | References | PDF (1 MB)
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Article
The effect of tubeimoside-1 on the proliferation, metastasis and apoptosis of oral squamous cell carcinoma in vitro
Tingting Wu, Hongjuan Cui, Yamei Xu, Quangao Du, Erhu Zhao, Jiangjun Cao, Ling Nie, Gang Fu & Aishu Ren
Pages: 3989-4000
Published online: 10 Jul 2018
AbstractforThe effect of tubeimoside-1 on the proliferation, metastasis and apoptosis of oral squamous cell carcinoma in vitro | Full Text | References | PDF (21.4 MB)
  • 69 Views
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Article
MFAP2 promotes epithelial–mesenchymal transition in gastric cancer cells by activating TGF-β/SMAD2/3 signaling pathway
Jian-Kai Wang, Wen-Juan Wang, Hong-Yi Cai, Bin-Bin Du, Ping Mai, Li-Juan Zhang, Wen Ma, Yong-Guo Hu, Shi-Fang Feng & Guo-Ying Miao
Pages: 4001-4017
Published online: 12 Jul 2018
AbstractforMFAP2 promotes epithelial–mesenchymal transition in gastric cancer cells by activating TGF-β/SMAD2/3 signaling pathway | Full Text | References | PDF (12.2 MB)
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Article
Downregulation and DNA methylation of ECRG4 in gastric cancer
Peng Deng, Xiao-Jing Chang, Zi-Ming Gao, Xiao-Yang Xu, An-Qi Sun, Kai Li & Dong-Qiu Dai
Pages: 4019-4028
Published online: 13 Jul 2018
AbstractforDownregulation and DNA methylation of ECRG4 in gastric cancer | Full Text | References | PDF (2.5 MB)
  • 61 Views
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Case Report

Case Report
Mutational analysis on gastric, duodenal, bone, and mediastinal lymph node metastases and blood from a case of primary lung adenocarcinoma
Xin Yang, Rui Chen, Chen Wu, Weiqing Zhao & Mei Ji
Pages: 4029-4034
Published online: 13 Jul 2018
AbstractforMutational analysis on gastric, duodenal, bone, and mediastinal lymph node metastases and blood from a case of primary lung adenocarcinoma | Full Text | References | PDF (1.2 MB)
  • 64 Views
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Original Research

Article
MSI2 knockdown represses extrahepatic cholangiocarcinoma growth and invasion by inhibiting epithelial–mesenchymal transition
Feihu Hu, Chenhai Liu, Fang Xie, Xiansheng Lin, Ji Yang, Chao Wang & Qiang Huang
Pages: 4035-4046
Published online: 13 Jul 2018
AbstractforMSI2 knockdown represses extrahepatic cholangiocarcinoma growth and invasion by inhibiting epithelial–mesenchymal transition | Full Text | References | PDF (11.3 MB)
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Case Report

Case Report
Long-term progression-free survival of third-line apatinib in lung squamous cell carcinoma
Xiaofen Li, Xia Li, Xuefeng Fang & Ying Yuan
Pages: 4047-4050
Published online: 16 Jul 2018
AbstractforLong-term progression-free survival of third-line apatinib in lung squamous cell carcinoma | Full Text | References | PDF (1.2 MB)
  • 56 Views
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Review

Review Article
New PDL1 inhibitors for non-small cell lung cancer: focus on pembrolizumab
Olivier Bylicki, Nicolas Paleiron, Gaëlle Rousseau-Bussac & Christos Chouaïd
Pages: 4051-4064
Published online: 16 Jul 2018
AbstractforNew PDL1 inhibitors for non-small cell lung cancer: focus on pembrolizumab | Full Text | References | PDF (395.9 KB)
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Article
MicroRNA-425 promotes the development of lung adenocarcinoma via targeting A disintegrin and metalloproteinases 9 (ADAM9)
Ruibao Liu, Fang Wang, Yanchun Guo, Jianmei Yang, Shaoping Chen, Xin Gao & Xunguo Wang
Pages: 4065-4073
Published online: 16 Jul 2018
AbstractforMicroRNA-425 promotes the development of lung adenocarcinoma via targeting A disintegrin and metalloproteinases 9 (ADAM9) | Full Text | References | PDF (869.9 KB)
  • 71 Views
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Article
MicroRNA-384 inhibits proliferation migration and invasion of glioma by targeting at CDC42
Gengshi Gu, Li Wang, Junchen Zhang, Hao Wang, Tan Tan & Guangning Zhang
Pages: 4075-4085
Published online: 16 Jul 2018
AbstractforMicroRNA-384 inhibits proliferation migration and invasion of glioma by targeting at CDC42 | Full Text | References | PDF (2.2 MB)
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Article
miR-19b serves as a prognostic biomarker of breast cancer and promotes tumor progression through PI3K/AKT signaling pathway
Chuansheng Li, Jingwei Zhang, Zhongliang Ma, Fan Zhang & Wenlong Yu
Pages: 4087-4095
Published online: 16 Jul 2018
AbstractformiR-19b serves as a prognostic biomarker of breast cancer and promotes tumor progression through PI3K/AKT signaling pathway | Full Text | References | PDF (2.7 MB)
  • 71 Views
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Article
TERT copy gain predicts the outcome of high-dose interferon α-2b therapy in acral melanoma
Sifan Yu, Tianxiao Xu, Jie Dai, Meng Ma, Huan Tang, Zhihong Chi, Lu Si, Chuanliang Cui, Xinan Sheng, Yan Kong & Jun Guo
Pages: 4097-4104
Published online: 17 Jul 2018
AbstractforTERT copy gain predicts the outcome of high-dose interferon α-2b therapy in acral melanoma | Full Text | References | PDF (856.8 KB)
  • 73 Views
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Article
Identification of potential core genes in triple negative breast cancer using bioinformatics analysis
Man-Xiu Li, Li-Ting Jin, Tie-Jun Wang, Yao-Jun Feng, Cui-Ping Pan, Dei-Mian Zhao & Jun Shao
Pages: 4105-4112
Published online: 18 Jul 2018
AbstractforIdentification of potential core genes in triple negative breast cancer using bioinformatics analysis | Full Text | References | PDF (2.7 MB)
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Review

Review Article
Pleiotropic functions of miR107 in cancer networks
Zhiying Luo, Yi Zheng & Wei Zhang
Pages: 4113-4124
Published online: 18 Jul 2018
AbstractforPleiotropic functions of miR107 in cancer networks | Full Text | References | PDF (419.3 KB)
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Article
Inhibition of MUC1-C entering nuclear suppresses MYC expression and attenuates malignant growth in esophageal squamous cell carcinoma
Zhongwei Xin, Gongsun Xin, Mo Shi, Liang Song, Qiang Wang, Bin Jiang & Xiangyan Liu
Pages: 4125-4136
Published online: 14 Nov 2022
AbstractforInhibition of MUC1-C entering nuclear suppresses MYC expression and attenuates malignant growth in esophageal squamous cell carcinoma | Full Text | References | PDF (15.2 MB)
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Review

Review Article
Progress in the treatment of solid tumors with apatinib: a systematic review
Deze Zhao, Helei Hou & Xiaochun Zhang
Pages: 4137-4147
Published online: 19 Jul 2018
AbstractforProgress in the treatment of solid tumors with apatinib: a systematic review | Full Text | References | PDF (636.2 KB)
  • 110 Views
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Original Research

Article
Efficacy and safety assessment of apatinib in patients with advanced gastric cancer: a meta-analysis
Jianxin Chen & Junhui Wang
Pages: 4149-4158
Published online: 19 Jul 2018
AbstractforEfficacy and safety assessment of apatinib in patients with advanced gastric cancer: a meta-analysis | Full Text | References | PDF (1.3 MB)
  • 52 Views
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Article
Expression of protein disulfide isomerase A3 precursor in colorectal cancer
Zhaowei Yang, Juan Liu, Qinghong Shi, Yang Chao, Yanqing Di, Jing Sun, Jiebing Zhang, Lihong Huang, Honghua Guo & Chengyan He
Pages: 4159-4166
Published online: 19 Jul 2018
AbstractforExpression of protein disulfide isomerase A3 precursor in colorectal cancer | Full Text | References | PDF (2.1 MB)
  • 65 Views
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Article
Prognostic and clinicopathological significance of Beclin-1 in non-small-cell lung cancer: a meta-analysis
Tianliang Zheng, Deping Li, Zhanfeng He, Shuaibing Feng & Song Zhao
Pages: 4167-4175
Published online: 14 Nov 2022
AbstractforPrognostic and clinicopathological significance of Beclin-1 in non-small-cell lung cancer: a meta-analysis | Full Text | References | PDF (1.3 MB)
  • 74 Views
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Article
DcR3 induces proliferation, migration, invasion, and EMT in gastric cancer cells via the PI3K/AKT/GSK-3β/β-catenin signaling pathway
Hua Ge, Chaojie Liang, Zhixia Li, Dali An, Shulin Ren, Chaosen Yue & Jixiang Wu
Pages: 4177-4187
Published online: 19 Jul 2018
AbstractforDcR3 induces proliferation, migration, invasion, and EMT in gastric cancer cells via the PI3K/AKT/GSK-3β/β-catenin signaling pathway | Full Text | References | PDF (4.6 MB)
  • 79 Views
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Article
Promoter methylation analysis of CDH1 and p14ARF genes in patients with urothelial bladder cancer
Bayram Bayramov, Sezgin Gunes, Recep Buyukalpelli, Oğuz Aydın & Ralf Henkel
Pages: 4189-4196
Published online: 19 Jul 2018
AbstractforPromoter methylation analysis of CDH1 and p14ARF genes in patients with urothelial bladder cancer | Full Text | References | PDF (638.3 KB)
  • 57 Views
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Article
SIK1-LNC represses the proliferative, migrative, and invasive abilities of lung cancer cells
Liu Yang, Nianlin Xie, Jingyu Huang, Hu Huang, Shaogan Xu, Zhigang Wang & Jun Cai
Pages: 4197-4206
Published online: 19 Jul 2018
AbstractforSIK1-LNC represses the proliferative, migrative, and invasive abilities of lung cancer cells | Full Text | References | PDF (5.1 MB)
  • 85 Views
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Article
Matrix metalloproteinase-7 may serve as a novel biomarker for cervical cancer
Linyan Zhu, Xiaojiao Zheng, Yongming Du, Yan Xing, Kejun Xu & Lining Cui
Pages: 4207-4220
Published online: 20 Jul 2018
AbstractforMatrix metalloproteinase-7 may serve as a novel biomarker for cervical cancer | Full Text | References | PDF (4.9 MB)
  • 93 Views
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Article
CEP55 promotes the proliferation, migration and invasion of esophageal squamous cell carcinoma via the PI3K/Akt pathway
Yang Jia, Zhaohua Xiao, Xin Gongsun, Zhongwei Xin, Bin Shang, Gang Chen, Zhou Wang & Wenpeng Jiang
Pages: 4221-4232
Published online: 14 Nov 2022
AbstractforCEP55 promotes the proliferation, migration and invasion of esophageal squamous cell carcinoma via the PI3K/Akt pathway | Full Text | References | PDF (4.7 MB)
  • 113 Views
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Article
Overexpression of Romo1 is an unfavorable prognostic biomarker and a predictor of lymphatic metastasis in non-small cell lung cancer patients
Hong Jun Kim, Min Jee Jo, Bo Ram Kim, Jung Lim Kim, Yoon A Jeong, Yoo Jin Na, Seong Hye Park, Suk-young Lee, Dae-Hee Lee, Baek-hui Kim, Young Do Yoo & Sang Cheul Oh
Pages: 4233-4246
Published online: 23 Jul 2018
AbstractforOverexpression of Romo1 is an unfavorable prognostic biomarker and a predictor of lymphatic metastasis in non-small cell lung cancer patients | Full Text | References | PDF (5.7 MB)
  • 83 Views
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Article
Comparable efficacy and less toxicity of pegylated liposomal doxorubicin versus epirubicin for neoadjuvant chemotherapy of breast cancer: a case-control study
Minjun Dong, Liang Luo, Xiaogang Ying, Xianqiu Lu, Jianguo Shen, Zhinong Jiang & Linbo Wang
Pages: 4247-4252
Published online: 14 Nov 2022
AbstractforComparable efficacy and less toxicity of pegylated liposomal doxorubicin versus epirubicin for neoadjuvant chemotherapy of breast cancer: a case-control study | Full Text | References | PDF (357.9 KB)
  • 121 Views
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Article
Transcobalamin I: a novel prognostic biomarker of neoadjuvant chemotherapy in locally advanced hypopharyngeal squamous cell cancers
Ying Wang, Changli Yue, Jugao Fang, Lili Gong, Meng Lian, Ru Wang, Ling Feng, Hongzhi Ma, Zhihong Ma & Honggang Liu
Pages: 4253-4261
Published online: 24 Jul 2018
AbstractforTranscobalamin I: a novel prognostic biomarker of neoadjuvant chemotherapy in locally advanced hypopharyngeal squamous cell cancers | Full Text | References | PDF (1.4 MB)
  • 78 Views
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Review

Review Article
Effects of miRNAs on functions of breast cancer stem cells and treatment of breast cancer
Ying Zhang, Bin Xu & Xi-ping Zhang
Pages: 4263-4270
Published online: 24 Jul 2018
AbstractforEffects of miRNAs on functions of breast cancer stem cells and treatment of breast cancer | Full Text | References | PDF (238 KB)
  • 169 Views
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Original Research

Article
Efficacy of bevacizumab versus epidermal growth factor receptor inhibitors for wild-type RAS metastatic colorectal cancer: a meta-analysis
Wei Jiang, Qitao Yu, Ruiling Ning, Wenhua Zhao & Changyuan Wei
Pages: 4271-4281
Published online: 14 Nov 2022
AbstractforEfficacy of bevacizumab versus epidermal growth factor receptor inhibitors for wild-type RAS metastatic colorectal cancer: a meta-analysis | Full Text | References | PDF (836.8 KB)
  • 177 Views
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Article
Analysis of change in microRNA expression profiles of lung cancer A549 cells treated with Radix tetrastigma hemsleyani flavonoids
Peigang Liu, Xu Yang, Hongjian Zhang, Jinbao Pu & Kemin Wei
Pages: 4283-4300
Published online: 24 Jul 2018
AbstractforAnalysis of change in microRNA expression profiles of lung cancer A549 cells treated with Radix tetrastigma hemsleyani flavonoids | Full Text | References | PDF (8.3 MB)
  • 91 Views
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Article
Delta-tocotrienol inhibits non-small-cell lung cancer cell invasion via the inhibition of NF-κB, uPA activator, and MMP-9
Lichchavi D Rajasinghe, Rohini H Pindiprolu & Smiti Vaid Gupta
Pages: 4301-4314
Published online: 24 Jul 2018
AbstractforDelta-tocotrienol inhibits non-small-cell lung cancer cell invasion via the inhibition of NF-κB, uPA activator, and MMP-9 | Full Text | References | PDF (2.3 MB)
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Article
Endoplasmic reticulum stress-mediated autophagy contributes to 5-ethylamino-9-diethylaminobenzo[a]phenoselenazinium-mediated photodynamic therapy via the PERK–eIF2α pathway
Jing Chen, Jin-Hua Huang, Zhen Wang, Xiangzhi Song, Zeyi Chen, Qinghai Zeng, Xiping Zhou, Zhihong Zuo, Shuang Zhao, Xiang Chen & Jian Kang
Pages: 4315-4325
Published online: 24 Jul 2018
AbstractforEndoplasmic reticulum stress-mediated autophagy contributes to 5-ethylamino-9-diethylaminobenzo[a]phenoselenazinium-mediated photodynamic therapy via the PERK–eIF2α pathway | Full Text | References | PDF (3.5 MB)
  • 62 Views
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Article
Identification of prognostic risk factors for esophageal adenocarcinoma using bioinformatics analysis
Zhiyu Dong, Junwen Wang, Tingting Zhan & Shuchang Xu
Pages: 4327-4337
Published online: 25 Jul 2018
AbstractforIdentification of prognostic risk factors for esophageal adenocarcinoma using bioinformatics analysis | Full Text | References | PDF (5.4 MB)
  • 92 Views
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Article
Polymorphism of IFN-γ +874T/A associated with production of IFN-γ affects human papillomavirus susceptibility in rural women from Luohe, Henan, China
Qing-wei Zhang, Jia-yu Song, Jiang-hua Yu, Ming-zhen Sun, Si-yuan Tang, Shao-zhe Yang, Lei-jia Cao, Hui-fen Wang, Li-na Cui & Xiu-hong Fu
Pages: 4339-4344
Published online: 14 Nov 2022
AbstractforPolymorphism of IFN-γ +874T/A associated with production of IFN-γ affects human papillomavirus susceptibility in rural women from Luohe, Henan, China | Full Text | References | PDF (396.1 KB)
  • 71 Views
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Article
18F-fluorodeoxyglucose positron emission tomography predicts lymph node responses to definitive chemoradiotherapy in esophageal squamous cell carcinoma patients
Wenyao Zhu, Yan Zhang, Li Kong, Yong Huang, Jinsong Zheng, Renben Wang, Minghuan Li & Jinming Yu
Pages: 4345-4353
Published online: 25 Jul 2018
Abstractfor18F-fluorodeoxyglucose positron emission tomography predicts lymph node responses to definitive chemoradiotherapy in esophageal squamous cell carcinoma patients | Full Text | References | PDF (2.1 MB)
  • 50 Views
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Article
The role of lncRNA CASC2 on prognosis of malignant tumors: a meta-analysis and bioinformatics
Lingling Yu, Shengsong Chen, Hui Bao, Weifang Zhang, Minqi Liao, Qian Liang & Xiaoshu Cheng
Pages: 4355-4365
Published online: 25 Jul 2018
AbstractforThe role of lncRNA CASC2 on prognosis of malignant tumors: a meta-analysis and bioinformatics | Full Text | References | PDF (2.2 MB)
  • 66 Views
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Study Protocol

Article
Elevated expression of Tiam1 is associated with poor prognosis and promotes tumor progression in pancreatic cancer
Mina Ding, Yue Li, Yang Yang, Kun Zhu, Shuanlong Che, Zhenhua Lin & Liyan Chen
Pages: 4367-4375
Published online: 26 Jul 2018
AbstractforElevated expression of Tiam1 is associated with poor prognosis and promotes tumor progression in pancreatic cancer | Full Text | References | PDF (2.6 MB)
  • 69 Views
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Original Research

Article
Extracts and components of Ficus carica leaves suppress survival, cell cycle, and migration of triple-negative breast cancer MDA-MB-231 cells
Yu Zhang, Youzhong Wan, Bo Huo, Boyuan Li, Yue Jin & Xin Hu
Pages: 4377-4386
Published online: 27 Jul 2018
AbstractforExtracts and components of Ficus carica leaves suppress survival, cell cycle, and migration of triple-negative breast cancer MDA-MB-231 cells | Full Text | References | PDF (2.3 MB)
  • 299 Views
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Review

Review Article
HOXA11-AS: a novel regulator in human cancer proliferation and metastasis
Jiang-yang Xue, Chao Huang, Wei Wang, Hai-bo Li, Ming Sun & Min Xie
Pages: 4387-4393
Published online: 14 Nov 2022
AbstractforHOXA11-AS: a novel regulator in human cancer proliferation and metastasis | Full Text | References | PDF (274.4 KB)
  • 118 Views
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Original Research

Article
Euphornin reduces proliferation of human cervical adenocarcinoma HeLa cells through induction of apoptosis and G2/M cell cycle arrest
Xiao-Qiang Li, Yin-Liang Bai, De-Li Zhang, Hai-Sheng Jiao & Rong-Xia He
Pages: 4395-4405
Published online: 27 Jul 2018
AbstractforEuphornin reduces proliferation of human cervical adenocarcinoma HeLa cells through induction of apoptosis and G2/M cell cycle arrest | Full Text | References | PDF (1.8 MB)
  • 84 Views
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Case Report

Case Report
Reversible posterior leukoencephalopathy syndrome induced by apatinib: a case report and literature review
Xutong Li, Jie Chai, Zhi Wang, Lin Lu, Qingye Zhao, Jie Zhou & Fang Ju
Pages: 4407-4411
Published online: 14 Nov 2022
AbstractforReversible posterior leukoencephalopathy syndrome induced by apatinib: a case report and literature review | Full Text | References | PDF (532.8 KB)
  • 62 Views
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Original Research

Article
Combination chemotherapy with Zyflamend reduced the acquired resistance of bladder cancer cells to cisplatin through inhibiting NFκB signaling pathway
Yanshi Xue, Lin Yang, Junzun Li, Yilin Yan, Qinghui Jiang, Lan Shen, Shuai Yang, Bing Shen, Ruimin Huang, Jun Yan & Hongqian Guo
Pages: 4413-4429
Published online: 30 Jul 2018
AbstractforCombination chemotherapy with Zyflamend reduced the acquired resistance of bladder cancer cells to cisplatin through inhibiting NFκB signaling pathway | Full Text | References | PDF (10.2 MB)
  • 72 Views
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Article
LINC00888 promoted tumorigenicity of melanoma via miR-126/CRK signaling axis
Wei Lu, Xiaohua Tao, Yibin Fan, Yi Tang, Xin Xu, Shasha Fan, Youming Huang, Yong Yu & Dan Luo
Pages: 4431-4442
Published online: 31 Jul 2018
AbstractforLINC00888 promoted tumorigenicity of melanoma via miR-126/CRK signaling axis | Full Text | References | PDF (2 MB)
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Article
Outcome of eribulin as a late treatment line for Thai metastatic breast cancer patients
Chagkrit Ditsatham, Imjai Chitapanarux, Areewan Somwangprasert, Kirati Watcharachan, Panchaporn Wongmaneerung, Chaiyut Charoentum, Busyamas Chewaskulyong, Somvilai Chakrabandhu, Wimrak Onchan, Anongnart Teeyasuntranonn & Patumrat Sripan
Pages: 4443-4447
Published online: 31 Jul 2018
AbstractforOutcome of eribulin as a late treatment line for Thai metastatic breast cancer patients | Full Text | References | PDF (572.7 KB)
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Corrigendum

Correction
Effect of first-line endocrine therapy in patients with hormone-sensitive advanced breast cancer: a network meta-analysis [Corrigendum]
Page: 4449
Published online: 31 Jul 2018
CitationforEffect of first-line endocrine therapy in patients with hormone-sensitive advanced breast cancer: a network meta-analysis [Corrigendum] | Full Text | PDF (150.8 KB)
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Original Research

Article
Metformin induces miR-378 to downregulate the CDK1, leading to suppression of cell proliferation in hepatocellular carcinoma
Jin Zhou, Sheng Han, Weichun Qian, Yuanyuan Gu, Xiangcheng Li & Kunxing Yang
Pages: 4451-4459
Published online: 31 Jul 2018
AbstractforMetformin induces miR-378 to downregulate the CDK1, leading to suppression of cell proliferation in hepatocellular carcinoma | Full Text | References | PDF (2.4 MB)
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Article
RETRACTED ARTICLE: miR-141-3p is a key negative regulator of the EGFR pathway in osteosarcoma
Jiashi Wang, Guangbin Wang, Bin Li, Chuang Qiu & Ming He
Pages: 4461-4478
Published online: 31 Jul 2018
AbstractforRETRACTED ARTICLE: miR-141-3p is a key negative regulator of the EGFR pathway in osteosarcoma | PDF (8.6 MB)
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Article
Cordycepin induces apoptosis in human pancreatic cancer cells via the mitochondrial-mediated intrinsic pathway and suppresses tumor growth in vivo
Yu Zhang, Xiao Xi Zhang, Rui Yan Yuan, Tai Ren, Zi Yu Shao, Hong Fei Wang, Wei Long Cai, Li Tian Chen, Xu An Wang & Ping Wang
Pages: 4479-4490
Published online: 01 Aug 2018
AbstractforCordycepin induces apoptosis in human pancreatic cancer cells via the mitochondrial-mediated intrinsic pathway and suppresses tumor growth in vivo | Full Text | References | PDF (11.3 MB)
  • 173 Views
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Article
Cancer/testis antigens (CTAs) expression in resected lung cancer
Shi Jin, Shoubo Cao, Jianhua Li, Qingwei Meng, Chunyan Wang, Lei Yao, Yaoguo Lang, Jingyan Cao, Jing Shen, Bo Pan, Jing Hu & Yan Yu
Pages: 4491-4499
Published online: 01 Aug 2018
AbstractforCancer/testis antigens (CTAs) expression in resected lung cancer | Full Text | References | PDF (670.3 KB)
  • 111 Views
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Article
HMGB1/RAGE axis mediates the apoptosis, invasion, autophagy, and angiogenesis of the renal cell carcinoma
Cun-Zao Wu, Jian-Jian Zheng, Yong-Heng Bai, Peng Xia, Hai-Cong Zhang & Yong Guo
Pages: 4501-4510
Published online: 14 Nov 2022
AbstractforHMGB1/RAGE axis mediates the apoptosis, invasion, autophagy, and angiogenesis of the renal cell carcinoma | Full Text | References | PDF (2.5 MB)
  • 95 Views
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Article
Melittin induces NSCLC apoptosis via inhibition of miR-183
Dongqi Gao, Jingjing Zhang, Lu Bai, Fubo Li, Yi Dong & Qingshan Li
Pages: 4511-4523
Published online: 01 Aug 2018
AbstractforMelittin induces NSCLC apoptosis via inhibition of miR-183 | Full Text | References | PDF (2.7 MB)
  • 116 Views
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Article
Relationship between HER2 gene status and selected potential biological features related to trastuzumab resistance and its influence on survival of breast cancer patients undergoing trastuzumab adjuvant treatment
Agnieszka Adamczyk, Anna Kruczak, Agnieszka Harazin-Lechowska, Aleksandra Ambicka, Aleksandra Grela-Wojewoda, Małgorzata Domagała-Haduch, Anna Janecka-Widła, Kaja Majchrzyk, Anna Cichocka, Janusz Ryś & Joanna Niemiec
Pages: 4525-4535
Published online: 03 Aug 2018
AbstractforRelationship between HER2 gene status and selected potential biological features related to trastuzumab resistance and its influence on survival of breast cancer patients undergoing trastuzumab adjuvant treatment | Full Text | References | PDF (2.7 MB)
  • 110 Views
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Article
Hypoxia-regulated lncRNA CRPAT4 promotes cell migration via regulating AVL9 in clear cell renal cell carcinomas
Wenhua Zhang, Jue Wang, Rong Chai, Guangxin Zhong, Cong Zhang, Wenjia Cao, Lei Yan, Xiang Zhang & Zhonghua Xu
Pages: 4537-4545
Published online: 03 Aug 2018
AbstractforHypoxia-regulated lncRNA CRPAT4 promotes cell migration via regulating AVL9 in clear cell renal cell carcinomas | Full Text | References | PDF (1.4 MB)
  • 79 Views
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Case Report

Case Report
Case report of a primary prostatic urothelial carcinoma patient with sustained fever
Songsong Zhang & Zhenxing Guo
Pages: 4547-4550
Published online: 03 Aug 2018
AbstractforCase report of a primary prostatic urothelial carcinoma patient with sustained fever | Full Text | References | PDF (1.6 MB)
  • 59 Views
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Original Research

Article
Prognostic value of selected preoperative inflammation-based scores in patients with high-risk localized prostate cancer who underwent radical prostatectomy
Kunpeng Shu, Yu Zheng, Junru Chen, Wenbin Li & Ke Jiang
Pages: 4551-4558
Published online: 03 Aug 2018
AbstractforPrognostic value of selected preoperative inflammation-based scores in patients with high-risk localized prostate cancer who underwent radical prostatectomy | Full Text | References | PDF (1 MB)
  • 62 Views
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Article
Phytochemical analysis and antioxidant and anticancer activities of mastic gum resin from Pistacia atlantica subspecies kurdica
Heshu Sulaiman Rahman
Pages: 4559-4572
Published online: 06 Aug 2018
AbstractforPhytochemical analysis and antioxidant and anticancer activities of mastic gum resin from Pistacia atlantica subspecies kurdica | Full Text | References | PDF (3.2 MB)
  • 457 Views
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Article
Change in non-small-cell lung cancer tumor size in patients treated with nintedanib plus docetaxel: analyses from the Phase III LUME-Lung 1 study
Martin Reck, Anders Mellemgaard, Silvia Novello, Pieter E Postmus, Birgit Gaschler-Markefski, Rolf Kaiser & Hannes Buchner
Pages: 4573-4582
Published online: 06 Aug 2018
AbstractforChange in non-small-cell lung cancer tumor size in patients treated with nintedanib plus docetaxel: analyses from the Phase III LUME-Lung 1 study | Full Text | References | PDF (1.3 MB)
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Review

Review Article
Brentuximab vedotin in Hodgkin lymphoma and anaplastic large-cell lymphoma: an evidence-based review
Eva M Donato, Miguel Fernández-Zarzoso, Jose Antonio Hueso & Javier de la Rubia
Pages: 4583-4590
Published online: 06 Aug 2018
AbstractforBrentuximab vedotin in Hodgkin lymphoma and anaplastic large-cell lymphoma: an evidence-based review | Full Text | References | PDF (272 KB)
  • 145 Views
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Review Article
Current status and dilemma of second-line treatment in advanced pancreatic cancer: is there a silver lining?
Jie Hua, Si Shi, Dingkong Liang, Chen Liang, Qingcai Meng, Bo Zhang, Quanxing Ni, Jin Xu & Xianjun Yu
Pages: 4591-4608
Published online: 14 Nov 2022
AbstractforCurrent status and dilemma of second-line treatment in advanced pancreatic cancer: is there a silver lining? | Full Text | References | PDF (779 KB)
  • 75 Views
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Original Research

Article
CTLA4 tagging polymorphisms and risk of colorectal cancer: a case–control study involving 2,306 subjects
Chen Zou, Hao Qiu, Weifeng Tang, Yafeng Wang, Bin Lan & Yu Chen
Pages: 4609-4619
Published online: 07 Aug 2018
AbstractforCTLA4 tagging polymorphisms and risk of colorectal cancer: a case–control study involving 2,306 subjects | Full Text | References | PDF (407.7 KB)
  • 97 Views
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Case Report

Case Report
Effective nivolumab sequential thoracic radiotherapy in elderly patients with advanced squamous cell lung cancer: did radiation therapy play a role? A case report
Grazia Lazzari, Angela Terlizzi, Giovanna Porrazzo, Salvatore Devicienti, Francesco Perri, Giuseppina Della Vittoria Scarpati & Giovanni Silvano
Pages: 4621-4629
Published online: 07 Aug 2018
AbstractforEffective nivolumab sequential thoracic radiotherapy in elderly patients with advanced squamous cell lung cancer: did radiation therapy play a role? A case report | Full Text | References | PDF (1.2 MB)
  • 70 Views
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Original Research

Article
A long noncoding RNA MAP3K1-2 promotes proliferation and invasion in gastric cancer
Lei Wu, Jia-Huan Yin, Yu-Yu Guan, Hai-Long Liu, Hai-Long Shen, Xiao-Jie Wang, Bao-Hua Han, Min-Wei Zhou & Xiao-Dong Gu
Pages: 4631-4639
Published online: 07 Aug 2018
AbstractforA long noncoding RNA MAP3K1-2 promotes proliferation and invasion in gastric cancer | Full Text | References | PDF (1.2 MB)
  • 53 Views
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Article
The efficacy and safety of intravesical gemcitabine vs Bacille Calmette-Guérin for adjuvant treatment of non-muscle invasive bladder cancer: a meta-analysis
Ziqi Ye, Jie Chen, Yun Hong, Wenxiu Xin, Si Yang & Yuefeng Rao
Pages: 4641-4649
Published online: 08 Aug 2018
AbstractforThe efficacy and safety of intravesical gemcitabine vs Bacille Calmette-Guérin for adjuvant treatment of non-muscle invasive bladder cancer: a meta-analysis | Full Text | References | PDF (2 MB)
  • 123 Views
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Article
Relationship of PPARG, PPARGC1A, and PPARGC1B polymorphisms with susceptibility to hepatocellular carcinoma in an eastern Chinese Han population
Sheng Zhang, Jiakai Jiang, Zhan Chen, Yafeng Wang, Weifeng Tang, Yu Chen & Longgen Liu
Pages: 4651-4660
Published online: 08 Aug 2018
AbstractforRelationship of PPARG, PPARGC1A, and PPARGC1B polymorphisms with susceptibility to hepatocellular carcinoma in an eastern Chinese Han population | Full Text | References | PDF (391 KB)
  • 68 Views
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Article
Eyes absent homologue 2 predicts a favorable prognosis in colorectal cancer
Jie Zheng, Fuao Cao, Xiaopei Huang, Kuvaneshan Ramen, Xiaowen Xu, Yan Zhu, Wenjun Chang, Yunfeng Shan & Aizhen Guo
Pages: 4661-4671
Published online: 08 Aug 2018
AbstractforEyes absent homologue 2 predicts a favorable prognosis in colorectal cancer | Full Text | References | PDF (3.9 MB)
  • 67 Views
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Review

Review Article
Drug response to PD-1/PD-L1 blockade: based on biomarkers
Qi Chen, Tianhe Li & Wentao Yue
Pages: 4673-4683
Published online: 08 Aug 2018
AbstractforDrug response to PD-1/PD-L1 blockade: based on biomarkers | Full Text | References | PDF (538.3 KB)
  • 160 Views
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Review Article
Stereotactic body radiotherapy using the CyberKnife® system in the treatment of patients with liver metastases: state of the art
Peter Ihnát, Eva Skácelíková, Milan Tesař & Igor Penka
Pages: 4685-4691
Published online: 10 Aug 2018
AbstractforStereotactic body radiotherapy using the CyberKnife® system in the treatment of patients with liver metastases: state of the art | Full Text | References | PDF (607.8 KB)
  • 151 Views
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Original Research

Article
B7-H3 promotes metastasis, proliferation, and epithelial-mesenchymal transition in lung adenocarcinoma
Ting-Ting Yu, Tao Zhang, Xi Lu & Ruo-Zheng Wang
Pages: 4693-4700
Published online: 10 Aug 2018
AbstractforB7-H3 promotes metastasis, proliferation, and epithelial-mesenchymal transition in lung adenocarcinoma | Full Text | References | PDF (2.6 MB)
  • 80 Views
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Article
Characterization of microRNA expression in primary human colon adenocarcinoma cells (SW480) and their lymph node metastatic derivatives (SW620)
Wei Yan, Wenchao Yang, Zhongcai Liu & Guoyang Wu
Pages: 4701-4709
Published online: 10 Aug 2018
AbstractforCharacterization of microRNA expression in primary human colon adenocarcinoma cells (SW480) and their lymph node metastatic derivatives (SW620) | Full Text | References | PDF (1.5 MB)
  • 117 Views
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Article
RETRACTED: miR-497 inhibited proliferation, migration and invasion of thyroid papillary carcinoma cells by negatively regulating YAP1 expression
Hui Cheng, Hui Dong, Jianlin Feng, Hongyan Tian, Haixia Zhang & Lina Xu
Pages: 4711-4721
Published online: 10 Aug 2018
AbstractforRETRACTED: miR-497 inhibited proliferation, migration and invasion of thyroid papillary carcinoma cells by negatively regulating YAP1 expression | PDF (4.2 MB)
  • 23 Views
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Article
Enhanced anticancer effects of low-dose curcumin with non-invasive pulsed electric field on PANC-1 cells
Chueh-Hsuan Lu, Shu-Hui Lin, Chih-Hsiung Hsieh, Wei-Ting Chen & Chih-Yu Chao
Pages: 4723-4732
Published online: 10 Aug 2018
AbstractforEnhanced anticancer effects of low-dose curcumin with non-invasive pulsed electric field on PANC-1 cells | Full Text | References | PDF (2.8 MB)
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Case Report

Case Report
Non-small cell lung cancer leptomeningeal metastases treated with intrathecal therapy plus osimertinib and temozolomide and whole-brain radiation therapy: a case report
Yunmei Wang, Shuguang Liu, Xiaohui Wei, Bin Yan, Jun Li, Zhixiang Su, Aiqin Liu & Yanjun Zhang
Pages: 4733-4738
Published online: 10 Aug 2018
AbstractforNon-small cell lung cancer leptomeningeal metastases treated with intrathecal therapy plus osimertinib and temozolomide and whole-brain radiation therapy: a case report | Full Text | References | PDF (1.4 MB)
  • 143 Views
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Case Report
The effectiveness of afatinib and osimertinib in a Chinese patient with advanced lung adenocarcinoma harboring a rare triple EGFR mutation (R670W/H835L/L833V): a case report and literature review
Bao-Dong Qin, Xiao-Dong Jiao, Ling-Yan Yuan, Ke Liu, Zhan Wang, Wen-Xing Qin & Yuan-Sheng Zang
Pages: 4739-4745
Published online: 10 Aug 2018
AbstractforThe effectiveness of afatinib and osimertinib in a Chinese patient with advanced lung adenocarcinoma harboring a rare triple EGFR mutation (R670W/H835L/L833V): a case report and literature review | Full Text | References | PDF (2.4 MB)
  • 197 Views
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Original Research

Article
Effect of KI-67 positive cellular index on prognosis after hepatectomy in Barcelona Clinic Liver Cancer stage A and B hepatocellular carcinoma with microvascular invasion
Hong-Hao Li, Lu-Nan Qi, Liang Ma, Zu-Shun Chen, Bang-De Xiang & Le-Qun Li
Pages: 4747-4754
Published online: 10 Aug 2018
AbstractforEffect of KI-67 positive cellular index on prognosis after hepatectomy in Barcelona Clinic Liver Cancer stage A and B hepatocellular carcinoma with microvascular invasion | Full Text | References | PDF (1 MB)
  • 104 Views
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Article
An integrated bioinformatical analysis to evaluate the role of KIF4A as a prognostic biomarker for breast cancer
Dan Xue, Pu Cheng, Mengjiao Han, Xiyong Liu, Lijun Xue, Chenyi Ye, Ke Wang & Jian Huang
Pages: 4755-4768
Published online: 14 Nov 2022
AbstractforAn integrated bioinformatical analysis to evaluate the role of KIF4A as a prognostic biomarker for breast cancer | Full Text | References | PDF (3.1 MB)
  • 103 Views
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Article
MSX1 induces G0/G1 arrest and apoptosis by suppressing Notch signaling and is frequently methylated in cervical cancer
Yujuan Yue, Kun Zhou, Jiachu Li, Shan Jiang, Chunyan Li & Haitao Men
Pages: 4769-4780
Published online: 10 Aug 2018
AbstractforMSX1 induces G0/G1 arrest and apoptosis by suppressing Notch signaling and is frequently methylated in cervical cancer | Full Text | References | PDF (1.7 MB)
  • 85 Views
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Article
sLAG-3 in non-small-cell lung cancer patients’ serum
Yayi He, Yan Wang, Sha Zhao, Chao Zhao, Caicun Zhou & Fred R Hirsch
Pages: 4781-4784
Published online: 13 Aug 2018
AbstractforsLAG-3 in non-small-cell lung cancer patients’ serum | Full Text | References | PDF (218.2 KB)
  • 87 Views
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Article
Apatinib-loaded lipid nanobubbles combined with ultrasound-targeted nanobubble destruction for synergistic treatment of HepG2 cells in vitro
Yuhang Tian, Zhao Liu, Lei Zhang, Jia Zhang, Xue Han, Qiucheng Wang & Wen Cheng
Pages: 4785-4795
Published online: 14 Nov 2022
AbstractforApatinib-loaded lipid nanobubbles combined with ultrasound-targeted nanobubble destruction for synergistic treatment of HepG2 cells in vitro | Full Text | References | PDF (4.4 MB)
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Review

Review Article
Intestinal microbiota: a novel perspective in colorectal cancer biotherapeutics
Chenbo Ding, Wendong Tang, Xiaobo Fan & Guoqiu Wu
Pages: 4797-4810
Published online: 13 Aug 2018
AbstractforIntestinal microbiota: a novel perspective in colorectal cancer biotherapeutics | Full Text | References | PDF (1.2 MB)
  • 172 Views
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Case Series

Mesenteric fibromatosis misdiagnosed with lymph node metastasis after successful laparoscopic right hemicolectomy: a report of two cases with review of literature
Peng Wang, Haitao Zhou, Zhixiang Zhou & Jianwei Liang
Pages: 4811-4816
Published online: 13 Aug 2018
AbstractforMesenteric fibromatosis misdiagnosed with lymph node metastasis after successful laparoscopic right hemicolectomy: a report of two cases with review of literature | Full Text | References | PDF (1.7 MB)
  • 56 Views
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Review

Review Article
Spotlight on copanlisib and its potential in the treatment of relapsed/refractory follicular lymphoma: evidence to date
Felix A Mensah, Jean-Pierre Blaize & Locke J Bryan
Pages: 4817-4827
Published online: 13 Aug 2018
AbstractforSpotlight on copanlisib and its potential in the treatment of relapsed/refractory follicular lymphoma: evidence to date | Full Text | References | PDF (359.1 KB)
  • 165 Views
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Review Article
Adenosquamous carcinoma of the lung
Chenghui Li & Hongyang Lu
Pages: 4829-4835
Published online: 14 Aug 2018
AbstractforAdenosquamous carcinoma of the lung | Full Text | References | PDF (286 KB)
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Original Research

Article
MicroRNA-194 regulates cell viability and apoptosis by targeting CDH2 in prostatic cancer
Song Gao, Zhiying Zhao, Rong Wu, Lina Wu, Xin Tian & Zhenyong Zhang
Pages: 4837-4844
Published online: 14 Aug 2018
AbstractforMicroRNA-194 regulates cell viability and apoptosis by targeting CDH2 in prostatic cancer | Full Text | References | PDF (1,006.4 KB)
  • 74 Views
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Article
Potential role of LINC00996 in colorectal cancer: a study based on data mining and bioinformatics
Hua Ge, Yan Yan, Di Wu, Yongsheng Huang & Fei Tian
Pages: 4845-4855
Published online: 14 Aug 2018
AbstractforPotential role of LINC00996 in colorectal cancer: a study based on data mining and bioinformatics | Full Text | References | PDF (2.3 MB)
  • 136 Views
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Article
Prognostic value of nutritional markers in nasopharyngeal carcinoma patients receiving intensity-modulated radiotherapy: a propensity score matching study
Ronald Wihal Oei, Lulu Ye, Juan Huang, Fangfang Kong, Tingting Xu, Chunying Shen, Xiaoshen Wang, Xiayun He, Lin Kong, Chaosu Hu & Hongmei Ying
Pages: 4857-4868
Published online: 14 Aug 2018
AbstractforPrognostic value of nutritional markers in nasopharyngeal carcinoma patients receiving intensity-modulated radiotherapy: a propensity score matching study | Full Text | References | PDF (1.4 MB)
  • 72 Views
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Article
PRMT7 contributes to the metastasis phenotype in human non-small-cell lung cancer cells possibly through the interaction with HSPA5 and EEF2
Dezhi Cheng, Zhifeng He, Liangcheng Zheng, Deyao Xie, Shangwen Dong & Peng Zhang
Pages: 4869-4876
Published online: 14 Aug 2018
AbstractforPRMT7 contributes to the metastasis phenotype in human non-small-cell lung cancer cells possibly through the interaction with HSPA5 and EEF2 | Full Text | References | PDF (2 MB)
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Article
Prognostic value of long noncoding RNAs in gastric cancer: a meta-analysis
Song Gao, Zhi-Ying Zhao, Rong Wu, Yue Zhang & Zhen-Yong Zhang
Pages: 4877-4891
Published online: 14 Aug 2018
AbstractforPrognostic value of long noncoding RNAs in gastric cancer: a meta-analysis | Full Text | References | PDF (3.2 MB)
  • 97 Views
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Article
Downregulation of lncRNA ANRIL suppresses growth and metastasis in human osteosarcoma cells
Hongya Guan, Yingwu Mei, Yang Mi, Cheng Li, Xiaoya Sun, Xuefeng Zhao, Jia Liu, Wei Cao, Yuebai Li & Yisheng Wang
Pages: 4893-4899
Published online: 14 Aug 2018
AbstractforDownregulation of lncRNA ANRIL suppresses growth and metastasis in human osteosarcoma cells | Full Text | References | PDF (1.4 MB)
  • 69 Views
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Article
MicroRNA-21-5p promotes proliferation of gastric cancer cells through targeting SMAD7
Yinan Jiang, Meiling Zhang, Tangxi Guo, Chaogang Yang, Chunxiao Zhang & Jinjin Hao
Pages: 4901-4911
Published online: 15 Aug 2018
AbstractforMicroRNA-21-5p promotes proliferation of gastric cancer cells through targeting SMAD7 | Full Text | References | PDF (2.1 MB)
  • 94 Views
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Article
The effects of beta-blocker use on cancer prognosis: a meta-analysis based on 319,006 patients
Zhijing Na, Xinbo Qiao, Xuanyu Hao, Ling Fan, Yao Xiao, Yining Shao, Mingwei Sun, Ziyi Feng, Wen Guo, Jiapo Li, Jiatong Li & Dongyang Li
Pages: 4913-4944
Published online: 20 Aug 2018
AbstractforThe effects of beta-blocker use on cancer prognosis: a meta-analysis based on 319,006 patients | Full Text | References | PDF (4.2 MB)
  • 161 Views
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Article
Injection of an SV40 transcriptional terminator causes embryonic lethality: a possible zebrafish model for screening nonhomologous end-joining inhibitors
Zhe Yang, Shihao Chen, Songlei Xue, Xinxiu Li, Jiang Hu, Zhen Sun & Hengmi Cui
Pages: 4945-4953
Published online: 17 Aug 2018
AbstractforInjection of an SV40 transcriptional terminator causes embryonic lethality: a possible zebrafish model for screening nonhomologous end-joining inhibitors | Full Text | References | PDF (901.5 KB)
  • 61 Views
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Article
Reduced expression of Nrdp1 predicts a poor prognosis in human hepatocellular carcinoma
Xian Shao, Qian Lu, Gang Wang, Wei Huang, Linlin Yang & Zhong Chen
Pages: 4955-4963
Published online: 17 Aug 2018
AbstractforReduced expression of Nrdp1 predicts a poor prognosis in human hepatocellular carcinoma | Full Text | References | PDF (1.8 MB)
  • 57 Views
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Article
Long non-coding RNA NAP1L6 promotes tumor progression and predicts poor prognosis in prostate cancer by targeting Inhibin-β A
Yuxiao Zheng, Yiren Gao, Xiao Li, Shuhui Si, Haoxiang Xu, Feng Qi, Jun Wang, Gong Cheng, Lixin Hua & Haiwei Yang
Pages: 4965-4977
Published online: 17 Aug 2018
AbstractforLong non-coding RNA NAP1L6 promotes tumor progression and predicts poor prognosis in prostate cancer by targeting Inhibin-β A | Full Text | References | PDF (5.4 MB)
  • 65 Views
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Article
High CEP55 expression is associated with poor prognosis in non-small-cell lung cancer
Chao Jiang, Yu Zhang, Yong Li, Jiabin Lu, Qitao Huang, Rui Xu, Yanfeng Feng & Shumei Yan
Pages: 4979-4990
Published online: 17 Aug 2018
AbstractforHigh CEP55 expression is associated with poor prognosis in non-small-cell lung cancer | Full Text | References | PDF (11.3 MB)
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Case Series

ALK-rearrangement neuroendocrine carcinoma of the lung: a comprehensive study of a rare case series and review of literature
Qiang Zheng, Mingjia Zheng, Yan Jin, Xuxia Shen, Ling Shan, Lei Shen, Yihua Sun, Haiquan Chen & Yuan Li
Pages: 4991-4998
Published online: 17 Aug 2018
AbstractforALK-rearrangement neuroendocrine carcinoma of the lung: a comprehensive study of a rare case series and review of literature | Full Text | References | PDF (3.3 MB)
  • 104 Views
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Original Research

Article
Long non-coding RNA MEG3 suppresses survival, migration, and invasion of cervical cancer
Xiuhui Chen & Junying Qu
Pages: 4999-5007
Published online: 20 Aug 2018
AbstractforLong non-coding RNA MEG3 suppresses survival, migration, and invasion of cervical cancer | Full Text | References | PDF (1.8 MB)
  • 101 Views
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Case Report

Case Report
Cauda equine syndrome as the primary symptom of leptomeningeal metastases from lung cancer: a case report and review of literature
Yang Liu, Bin Wang, Yongxiang Qian, Dongmei Di, Min Wang & Xiaoying Zhang
Pages: 5009-5013
Published online: 20 Aug 2018
AbstractforCauda equine syndrome as the primary symptom of leptomeningeal metastases from lung cancer: a case report and review of literature | Full Text | References | PDF (478.7 KB)
  • 78 Views
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Original Research

Article
Molecular mechanism of activated T cells in breast cancer
Jie Wu, Maolan Li, Yijian Zhang, Yan Cai & Gaiping Zhao
Pages: 5015-5024
Published online: 20 Aug 2018
AbstractforMolecular mechanism of activated T cells in breast cancer | Full Text | References | PDF (2.3 MB)
  • 66 Views
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Article
Minichromosome maintenance protein 2 correlates with the malignant status and regulates proliferation and cell cycle in lung squamous cell carcinoma
Wei Wu, Xianwei Wang, Changting Shan, Yong Li & Fengzhu Li
Pages: 5025-5034
Published online: 20 Aug 2018
AbstractforMinichromosome maintenance protein 2 correlates with the malignant status and regulates proliferation and cell cycle in lung squamous cell carcinoma | Full Text | References | PDF (1.6 MB)
  • 86 Views
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Article
Long noncoding RNA XIST promotes proliferation and invasion by targeting miR-141 in papillary thyroid carcinoma
Yawei Xu, Junrong Wang & Junling Wang
Pages: 5035-5043
Published online: 21 Aug 2018
AbstractforLong noncoding RNA XIST promotes proliferation and invasion by targeting miR-141 in papillary thyroid carcinoma | Full Text | References | PDF (1.7 MB)
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Retraction

Retraction
Ablation of MCM10 using CRISPR/Cas9 restrains the growth and migration of esophageal squamous cell carcinoma cells through inhibition of Akt signaling [Retraction]
Page: 5045
Published online: 21 Aug 2018
CitationforAblation of MCM10 using CRISPR/Cas9 restrains the growth and migration of esophageal squamous cell carcinoma cells through inhibition of Akt signaling [Retraction] | Full Text | PDF (142.4 KB)
  • 58 Views
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Original Research

Article
Analysis of the clinical significance of DCLK1+ colorectal cancer using novel monoclonal antibodies against DCLK1
Tianqi Dai, Yunlong Hu, Fulian Lv, Tatsuhiko Ozawa, Xin Sun, Jingjing Huang, Xiaojian Han, Hiroyuki Kishi, Atsushi Muraguchi & Aishun Jin
Pages: 5047-5057
Published online: 21 Aug 2018
AbstractforAnalysis of the clinical significance of DCLK1+ colorectal cancer using novel monoclonal antibodies against DCLK1 | Full Text | References | PDF (2.9 MB)
  • 97 Views
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Article
Risk of bleeding associated with antiangiogenic monoclonal antibodies bevacizumab and ramucirumab: a meta-analysis of 85 randomized controlled trials
Bingkun Xiao, Weilan Wang & Dezhi Zhang
Pages: 5059-5074
Published online: 21 Aug 2018
AbstractforRisk of bleeding associated with antiangiogenic monoclonal antibodies bevacizumab and ramucirumab: a meta-analysis of 85 randomized controlled trials | Full Text | References | PDF (1,002.7 KB)
  • 171 Views
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Article
miRNA-543 promotes cell migration and invasion by targeting SPOP in gastric cancer
Junfei Xu, Feiran Wang, Xi Wang, Zhixian He & Xinguo Zhu
Pages: 5075-5082
Published online: 21 Aug 2018
AbstractformiRNA-543 promotes cell migration and invasion by targeting SPOP in gastric cancer | Full Text | References | PDF (2 MB)
  • 53 Views
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Article
Prognostic and clinicopathological significance of DEPTOR expression in cancer patients: a meta-analysis
Binwu Hu, Deyao Shi, Xiao Lv, Fashuai Wu, Songfeng Chen & Zengwu Shao
Pages: 5083-5092
Published online: 22 Aug 2018
AbstractforPrognostic and clinicopathological significance of DEPTOR expression in cancer patients: a meta-analysis | Full Text | References | PDF (925 KB)
  • 73 Views
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Review

Review Article
Spotlight on lorlatinib and its potential in the treatment of NSCLC: the evidence to date
Takaki Akamine, Gouji Toyokawa, Tetsuzo Tagawa & Takashi Seto
Pages: 5093-5101
Published online: 22 Aug 2018
AbstractforSpotlight on lorlatinib and its potential in the treatment of NSCLC: the evidence to date | Full Text | References | PDF (521.6 KB)
  • 195 Views
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Original Research

Article
Effect of lncRNA ANRIL silencing on anoikis and cell cycle in human glioma via microRNA-203a
Weiying Dai, Chao Tian & Song Jin
Pages: 5103-5109
Published online: 23 Aug 2018
AbstractforEffect of lncRNA ANRIL silencing on anoikis and cell cycle in human glioma via microRNA-203a | Full Text | References | PDF (990.8 KB)
  • 61 Views
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Article
MiRNA-16 inhibited oral squamous carcinoma tumor growth in vitro and in vivo via suppressing Wnt/β-catenin signaling pathway
Lijun Liu, Han Jiang, Jin Zhao & Hao Wen
Pages: 5111-5119
Published online: 23 Aug 2018
AbstractforMiRNA-16 inhibited oral squamous carcinoma tumor growth in vitro and in vivo via suppressing Wnt/β-catenin signaling pathway | Full Text | References | PDF (1.8 MB)
  • 98 Views
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Article
Synergistic antitumoral efficacy of a novel replicative adenovirus SG611-PDCD5 and daunorubicin in human leukemic cells
Ya-Lan Zhou, Qiu-Mei Yao, Jiao Zhou, Yan Chang, Jin-Lan Li, Ya-Zhe Wang, Hong-Ping Wu, Yu-Hong Chen, Yan-Rong Liu, Xiao-Jun Huang & Guo-Rui Ruan
Pages: 5121-5132
Published online: 23 Aug 2018
AbstractforSynergistic antitumoral efficacy of a novel replicative adenovirus SG611-PDCD5 and daunorubicin in human leukemic cells | Full Text | References | PDF (3.2 MB)
  • 59 Views
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Article
Antitumor effects of nadroparin combined with radiotherapy in Lewis lung cancer models
Xibing Zhuang, Tiankui Qiao, Sujuan Yuan, Qi Zhang, Wei Chen, Youjun Luo & Guoxiong Xu
Pages: 5133-5142
Published online: 24 Aug 2018
AbstractforAntitumor effects of nadroparin combined with radiotherapy in Lewis lung cancer models | Full Text | References | PDF (2.8 MB)
  • 53 Views
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Article
Peripheral blood lymphocyte responses to cytomegalovirus seropositivity after allogeneic-hematopoietic stem cell transplantation
Jiexin Zhang, Xian Chen, Guodong Rong, Ting Xu, Hong Zhao, Dan Chen, Lei Wu, Peijun Huang & Fang Wang
Pages: 5143-5150
Published online: 24 Aug 2018
AbstractforPeripheral blood lymphocyte responses to cytomegalovirus seropositivity after allogeneic-hematopoietic stem cell transplantation | Full Text | References | PDF (1.2 MB)
  • 54 Views
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Article
Targeting the autophagy in bone marrow stromal cells overcomes resistance to vorinostat in chronic lymphocytic leukemia
Lu Ding, Wan Zhang, Lili Yang, Helene Pelicano, Kaiwen Zhou, Ran Yin, Ruibin Huang & Junyi Zeng
Pages: 5151-5170
Published online: 24 Aug 2018
AbstractforTargeting the autophagy in bone marrow stromal cells overcomes resistance to vorinostat in chronic lymphocytic leukemia | Full Text | References | PDF (3.2 MB)
  • 75 Views
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Article
Prognostic value of SOX2, Cyclin D1, P53, and ki-67 in patients with esophageal squamous cell carcinoma
Hui Wang, Yaxing Zhou, Qian Liu, Jiarong Xu & Yuqing Ma
Pages: 5171-5181
Published online: 24 Aug 2018
AbstractforPrognostic value of SOX2, Cyclin D1, P53, and ki-67 in patients with esophageal squamous cell carcinoma | Full Text | References | PDF (3.4 MB)
  • 63 Views
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Article
125I seed brachytherapy versus external beam radiation therapy for the palliation of painful bone metastases of lung cancer after one cycle of chemotherapy progression
Zhanwang Xiang, Lifei Wang, Huzheng Yan, Zhihui Zhong, Wangkai Liu, Zhiqiang Mo, Fei Gao & Fujun Zhang
Pages: 5183-5193
Published online: 14 Nov 2022
Abstractfor125I seed brachytherapy versus external beam radiation therapy for the palliation of painful bone metastases of lung cancer after one cycle of chemotherapy progression | Full Text | References | PDF (1.6 MB)
  • 101 Views
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Article
Alternative treatment strategies to sorafenib in patients with advanced hepatocellular carcinoma: a meta-analysis of randomized Phase III trials
Hui Wang, Hefang Wang, Zhichong Yu & Honghao Liu
Pages: 5195-5201
Published online: 27 Aug 2018
AbstractforAlternative treatment strategies to sorafenib in patients with advanced hepatocellular carcinoma: a meta-analysis of randomized Phase III trials | Full Text | References | PDF (699.7 KB)
  • 78 Views
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Case Report

Case Report
Radiotherapy for one rectal cancer patient with cirrhosis and moderate to severe thrombocytopenia: a case report
Xinqi Shi, Huifang Xia, Weiwei Zhang, Guang Li & Ailin Li
Pages: 5203-5207
Published online: 27 Aug 2018
AbstractforRadiotherapy for one rectal cancer patient with cirrhosis and moderate to severe thrombocytopenia: a case report | Full Text | References | PDF (1.2 MB)
  • 51 Views
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Original Research

Article
Overexpression of long noncoding RNA LINC00882 is associated with poor prognosis in hepatocellular carcinoma
Lei Zhu, Feizhou Huang, Tao Wan, Hongbo Xu & Qian Zhao
Pages: 5209-5217
Published online: 13 Sep 2018
AbstractforOverexpression of long noncoding RNA LINC00882 is associated with poor prognosis in hepatocellular carcinoma | Full Text | References | PDF (3 MB)
  • 61 Views
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Article
Magnolol exerts anticancer activity in hepatocellular carcinoma cells through regulating endoplasmic reticulum stress-mediated apoptotic signaling
Ya-Dong Wang, Xue-Jun Sun, Wei-Jun Yang, Jing Li & Jia-Jun Yin
Pages: 5219-5226
Published online: 28 Aug 2018
AbstractforMagnolol exerts anticancer activity in hepatocellular carcinoma cells through regulating endoplasmic reticulum stress-mediated apoptotic signaling | Full Text | References | PDF (3.1 MB)
  • 64 Views
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Article
Surgical therapy and next-generation sequencing-based genetic alteration analysis of malignant solitary fibrous tumor of the pleura
Zuoqing Song, Fan Yang, Yingguo Zhang, Ping Fan, Guowei Liu, Chao Li, Wansheng Ding, Yulong Zhang, Xiaohong Xu & Yancheng Ye
Pages: 5227-5238
Published online: 14 Nov 2022
AbstractforSurgical therapy and next-generation sequencing-based genetic alteration analysis of malignant solitary fibrous tumor of the pleura | Full Text | References | PDF (2.8 MB)
  • 93 Views
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Article
miR-361-5p inhibits glioma migration and invasion by targeting SND1
Jing Liu, Jie Yang, Lin Yu, Chun Rao, Qian Wang, Cuiyun Sun, Cuijuan Shi, Dan Hua, Xuexia Zhou, Wenjun Luo, Run Wang, Weiping Li & Shizhu Yu
Pages: 5239-5252
Published online: 28 Aug 2018
AbstractformiR-361-5p inhibits glioma migration and invasion by targeting SND1 | Full Text | References | PDF (5.4 MB)
  • 65 Views
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Review

Review Article
Profile of abemaciclib and its potential in the treatment of breast cancer
James M Martin & Lori J Goldstein
Pages: 5253-5259
Published online: 29 Aug 2018
AbstractforProfile of abemaciclib and its potential in the treatment of breast cancer | Full Text | References | PDF (250.2 KB)
  • 385 Views
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Original Research

Article
Prognostic role of aspartate aminotransferase-lymphocyte ratio index in patients with metastatic colorectal cancer: results from the randomized ITACa trial
Andrea Casadei Gardini, Emanuela Scarpi, Elena Orlandi, Davide Tassinari, Silvana Leo, Ilaria Bernardini, Fabio Gelsomino, Stefano Tamberi, Silvia Ruscelli, Roberto Vespignani, Sonia Ronconi, Giovanni Luca Frassineti, Dino Amadori & Alessandro Passardi
Pages: 5261-5268
Published online: 29 Aug 2018
AbstractforPrognostic role of aspartate aminotransferase-lymphocyte ratio index in patients with metastatic colorectal cancer: results from the randomized ITACa trial | Full Text | References | PDF (832.2 KB)
  • 74 Views
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Article
RETRACTED ARTICLE: Long noncoding RNA Sox2 overlapping transcript (SOX2OT) promotes non-small-cell lung cancer migration and invasion via sponging microRNA 132 (miR-132)
Kewei Zhang, Yang Li, Limei Qu, Xiaobo Ma, Hongguang Zhao & Ying Tang
Pages: 5269-5278
Published online: 30 Aug 2018
AbstractforRETRACTED ARTICLE: Long noncoding RNA Sox2 overlapping transcript (SOX2OT) promotes non-small-cell lung cancer migration and invasion via sponging microRNA 132 (miR-132) | PDF (2.6 MB)
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Article
Microsurgical treatment of parafalcine meningiomas: a retrospective study of 126 cases
Xiangyi Kong, Shun Gong, I-Ting Lee & Yi Yang
Pages: 5279-5285
Published online: 30 Aug 2018
AbstractforMicrosurgical treatment of parafalcine meningiomas: a retrospective study of 126 cases | Full Text | References | PDF (579.3 KB)
  • 85 Views
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Case Report

Case Report
Successful treatment of relapsed testicular embryonal rhabdomyosarcoma with Endostar and traditional chemotherapy: a case report
Tao Han, Jianjun Chen, Yuting Luan, Xiaoxia Chen, Xiaodan Yang, Yue Zhang, Gao Li, Di Wang & Zhendong Zheng
Pages: 5287-5291
Published online: 30 Aug 2018
AbstractforSuccessful treatment of relapsed testicular embryonal rhabdomyosarcoma with Endostar and traditional chemotherapy: a case report | Full Text | References | PDF (1.7 MB)
  • 67 Views
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Original Research

Article
miR-376a inhibits breast cancer cell progression by targeting neuropilin-1 NR
Lansheng Zhang, Yanwei Chen, Hui Wang, Xia Zheng, Caihong Li & Zhengxiang Han
Pages: 5293-5302
Published online: 30 Aug 2018
AbstractformiR-376a inhibits breast cancer cell progression by targeting neuropilin-1 NR | Full Text | References | PDF (3.2 MB)
  • 101 Views
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Article
E2F3 promotes cancer growth and is overexpressed through copy number variation in human melanoma
Zhicai Feng, Cheng Peng, Daojiang Li, Danhua Zhang, Xu Li, Fengran Cui, Yanhong Chen & Quanyong He
Pages: 5303-5313
Published online: 30 Aug 2018
AbstractforE2F3 promotes cancer growth and is overexpressed through copy number variation in human melanoma | Full Text | References | PDF (2.3 MB)
  • 85 Views
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Article
Eukaryotic translation initiation factor 3 subunit G (EIF3G) resensitized HCT116/5-Fu to 5-fluorouracil (5-Fu) via inhibition of MRP and MDR1
Chenggang Yang, Xin Liu, Chaobin Li, Shuangjing Li, Wenfeng Du & Daogui Yang
Pages: 5315-5324
Published online: 31 Aug 2018
AbstractforEukaryotic translation initiation factor 3 subunit G (EIF3G) resensitized HCT116/5-Fu to 5-fluorouracil (5-Fu) via inhibition of MRP and MDR1 | Full Text | References | PDF (1.8 MB)
  • 90 Views
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Article
Prognostic role of long non-coding RNA HNF1A-AS1 in Chinese cancer patients: a meta-analysis
Chunbo Zhuang, Lei Zheng & Pei Wang
Pages: 5325-5332
Published online: 31 Aug 2018
AbstractforPrognostic role of long non-coding RNA HNF1A-AS1 in Chinese cancer patients: a meta-analysis | Full Text | References | PDF (992.5 KB)
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Case Series

Apatinib mesylate tablet in the treatment of advanced malignant melanoma
Lingge Yang, Huiyan Zhu, Peng Luo, Shiqi Chen, Yu Xu & Chunmeng Wang
Pages: 5333-5338
Published online: 31 Aug 2018
AbstractforApatinib mesylate tablet in the treatment of advanced malignant melanoma | Full Text | References | PDF (2 MB)
  • 62 Views
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Case Report

Case Report
Lymphangioleiomyomatosis: a case report and review of diagnosis and treatment
Yi Liu, Zhibin Guo, Chenlong Zhao, Xin Li, Hongyu Liu & Jun Chen
Pages: 5339-5347
Published online: 31 Aug 2018
AbstractforLymphangioleiomyomatosis: a case report and review of diagnosis and treatment | Full Text | References | PDF (2.4 MB)
  • 118 Views
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Original Research

Article
Genome-wide profiling reveals cancer-related genes with switched alternative polyadenylation sites in colorectal cancer
Xiaochen Yang, Jun Wu, Wei Xu, Sheng Tan, Changyu Chen, Xiaoyan Wang, Jielin Sun & Yani Kang
Pages: 5349-5357
Published online: 31 Aug 2018
AbstractforGenome-wide profiling reveals cancer-related genes with switched alternative polyadenylation sites in colorectal cancer | Full Text | References | PDF (1.8 MB)
  • 53 Views
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Article
SRPK1 is a poor prognostic indicator and a novel potential therapeutic target for human colorectal cancer
Nan Yi, Mingbing Xiao, Feng Jiang, Zhaoxiu Liu, Wenkai Ni, Cuihua Lu, Runzhou Ni & Weichang Chen
Pages: 5359-5370
Published online: 03 Sep 2018
AbstractforSRPK1 is a poor prognostic indicator and a novel potential therapeutic target for human colorectal cancer | Full Text | References | PDF (4.4 MB)
  • 87 Views
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Article
STARD13 is positively correlated with good prognosis and enhances 5-FU sensitivity via suppressing cancer stemness in hepatocellular carcinoma cells
Fei Gao, Xiaolin Yu, Rongqin Meng, Jisheng Wang & Lin Jia
Pages: 5371-5381
Published online: 31 Aug 2018
AbstractforSTARD13 is positively correlated with good prognosis and enhances 5-FU sensitivity via suppressing cancer stemness in hepatocellular carcinoma cells | Full Text | References | PDF (3.6 MB)
  • 65 Views
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Article
Expression profiles of long noncoding RNAs in lung adenocarcinoma
Bing Zhao, Hang Xu, Xiaoye Ai, Yasheng Adalat, Ying Tong, Jiazhennan Zhang & Shune Yang
Pages: 5383-5390
Published online: 06 Sep 2018
AbstractforExpression profiles of long noncoding RNAs in lung adenocarcinoma | Full Text | References | PDF (1.5 MB)
  • 63 Views
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Case Report

Case Report
Successful cisplatin-etoposide chemotherapy-based treatment of a primary small cell neuroendocrine carcinoma of the tonsil with multiple metastases: a case report
Xing Wang, Qiming Chen & Jian Meng
Pages: 5391-5395
Published online: 03 Sep 2018
AbstractforSuccessful cisplatin-etoposide chemotherapy-based treatment of a primary small cell neuroendocrine carcinoma of the tonsil with multiple metastases: a case report | Full Text | References | PDF (2.5 MB)
  • 94 Views
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Original Research

Article
RGD-modified nanoliposomes containing quercetin for lung cancer targeted treatment
Xiao Zhou, Hong-Yan Liu, Hui Zhao & Tong Wang
Pages: 5397-5405
Published online: 03 Sep 2018
AbstractforRGD-modified nanoliposomes containing quercetin for lung cancer targeted treatment | Full Text | References | PDF (2.7 MB)
  • 148 Views
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Article
Postoperative adjuvant chemo (embolization) therapy for hepatocellular carcinoma with portal vein tumor thrombosis
Ya-Fei Zhang, Hao Shang, Xian-Ling Zeng, Hong Ji, Yi-Ming Li & Hong-Wei Lu
Pages: 5407-5417
Published online: 03 Sep 2018
AbstractforPostoperative adjuvant chemo (embolization) therapy for hepatocellular carcinoma with portal vein tumor thrombosis | Full Text | References | PDF (1.6 MB)
  • 65 Views
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Article
RETRACTED ARTICLE: MicroRNA 628 suppresses migration and invasion of breast cancer stem cells through targeting SOS1
Chenghui Lin, Bin Gao, Xuemao Yan, Zixiong Lei, Kebing Chen, Yuquan Li, Qing Zeng, Zeqin Chen & Haomiao Li
Pages: 5419-5428
Published online: 04 Sep 2018
AbstractforRETRACTED ARTICLE: MicroRNA 628 suppresses migration and invasion of breast cancer stem cells through targeting SOS1 | PDF (3.1 MB)
  • 57 Views
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Article
Natural borneol is a novel chemosensitizer that enhances temozolomide-induced anticancer efficiency against human glioma by triggering mitochondrial dysfunction and reactive oxide species-mediated oxidative damage
Wen-Jian Liu, Yi-Bo Yin, Jing-Yi Sun, Sai Feng, Jin-Kui Ma, Xiao-Yan Fu, Ya-Jun Hou, Ming-Feng Yang, Bao-Liang Sun & Cun-Dong Fan
Pages: 5429-5439
Published online: 04 Sep 2018
AbstractforNatural borneol is a novel chemosensitizer that enhances temozolomide-induced anticancer efficiency against human glioma by triggering mitochondrial dysfunction and reactive oxide species-mediated oxidative damage | Full Text | References | PDF (3.1 MB)
  • 91 Views
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Article
Mifepristone inhibits proliferation, migration and invasion of HUUA cells and promotes its apoptosis by regulation of FAK and PI3K/AKT signaling pathway
Lin Sang, Dawei Lu, Jun Zhang, Shihua Du & Xingbo Zhao
Pages: 5441-5449
Published online: 04 Sep 2018
AbstractforMifepristone inhibits proliferation, migration and invasion of HUUA cells and promotes its apoptosis by regulation of FAK and PI3K/AKT signaling pathway | Full Text | References | PDF (3.7 MB)
  • 82 Views
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Article
Prognostic value of CD44v6 expression in breast cancer: a meta-analysis
Guang-Lei Qiao, Li-Na Song, Zhou-feng Deng, Ying Chen & Li-Jun Ma
Pages: 5451-5457
Published online: 04 Sep 2018
AbstractforPrognostic value of CD44v6 expression in breast cancer: a meta-analysis | Full Text | References | PDF (713 KB)
  • 91 Views
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Case Series

Clinical benefit of fulvestrant monotherapy in the multimodal treatment of hormone receptor and HER2 positive advanced breast cancer: a case series
Orsolya Rusz, Renáta Kószó, Ágnes Dobi, Melinda Csenki, Erzsébet Valicsek, Alíz Nikolényi, Gabriella Uhercsák, Adrienne Cserháti & Zsuzsanna Kahán
Pages: 5459-5463
Published online: 04 Sep 2018
AbstractforClinical benefit of fulvestrant monotherapy in the multimodal treatment of hormone receptor and HER2 positive advanced breast cancer: a case series | Full Text | References | PDF (1.2 MB)
  • 88 Views
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Original Research

Article
Altered fractionation radiotherapy with or without chemotherapy in the treatment of head and neck cancer: a network meta-analysis
Yingyu Liu, Changgui Kou, Wei Bai, Xinyu Liu, Yan Song, Lili Zhang, Mohan Wang, Yangyu Zhang, Yueyue You, Yue Yin, Xin Jiang & Ying Xin
Pages: 5465-5483
Published online: 04 Sep 2018
AbstractforAltered fractionation radiotherapy with or without chemotherapy in the treatment of head and neck cancer: a network meta-analysis | Full Text | References | PDF (836.7 KB)
  • 87 Views
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Article
Absence of AIF1L contributes to cell migration and a poor prognosis of breast cancer
Peipei Liu, Wenhui Li, Yuanyuan Hu & Youhong Jiang
Pages: 5485-5498
Published online: 05 Sep 2018
AbstractforAbsence of AIF1L contributes to cell migration and a poor prognosis of breast cancer | Full Text | References | PDF (2.4 MB)
  • 116 Views
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Article
Suppression of c-MET overcomes erlotinib resistance in tongue cancer cells
Keqiang Huang & Dongxu Liu
Pages: 5499-5508
Published online: 05 Sep 2018
AbstractforSuppression of c-MET overcomes erlotinib resistance in tongue cancer cells | Full Text | References | PDF (4.2 MB)
  • 54 Views
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Article
Comparison of efficacy and toxicity between nedaplatin and cisplatin in treating malignant pleural effusion
Li-Zhe Zhong, Hong-Yan Xu, Zhong-Min Zhao, Guang-Mei Zhang & Feng-Wu Lin
Pages: 5509-5512
Published online: 05 Sep 2018
AbstractforComparison of efficacy and toxicity between nedaplatin and cisplatin in treating malignant pleural effusion | Full Text | References | PDF (238.7 KB)
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Corrigendum

Correction
An evaluation of the clinical diagnostic value of contrast-enhanced ultrasound combined with contrast-enhanced computed tomography in space-occupying lesions of the kidney [Corrigendum]
Page: 5513
Published online: 05 Sep 2018
CitationforAn evaluation of the clinical diagnostic value of contrast-enhanced ultrasound combined with contrast-enhanced computed tomography in space-occupying lesions of the kidney [Corrigendum] | Full Text | PDF (143.3 KB)
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Review

Review Article
Prognostic significance of NANOG expression in solid tumors: a meta-analysis
Lingqiong Zhao, Jie Liu, Shu Chen, Chun Fang, Xianquan Zhang & Zhibin Luo
Pages: 5515-5526
Published online: 06 Sep 2018
AbstractforPrognostic significance of NANOG expression in solid tumors: a meta-analysis | Full Text | References | PDF (1.5 MB)
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Original Research

Article
Feasibility of radical hysterectomy in women with FIGO stage IIB cervical cancer: an observation study of 10-year experience in a tertiary center
Lei Yuan, Jiaqi Guo, Xiaochun Zhang, Mo Chen, Congjian Xu & Liangqing Yao
Pages: 5527-5533
Published online: 19 Sep 2018
AbstractforFeasibility of radical hysterectomy in women with FIGO stage IIB cervical cancer: an observation study of 10-year experience in a tertiary center | Full Text | References | PDF (679.2 KB)
  • 73 Views
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Article
Nomograms for predicting long-term overall survival and disease-specific survival of patients with clear cell renal cell carcinoma
Guanghao Zhang, Yun Wu, Jiashu Zhang, Zhiqing Fang, Zhaoxu Liu, Zhonghua Xu & Yidong Fan
Pages: 5535-5544
Published online: 06 Sep 2018
AbstractforNomograms for predicting long-term overall survival and disease-specific survival of patients with clear cell renal cell carcinoma | Full Text | References | PDF (726.5 KB)
  • 118 Views
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Case Report

Case Report
Effective treatment of pulmonary adenocarcinoma harboring triple EGFR mutations of L858R, T790M, and cis-C797S by osimertinib, bevacizumab, and brigatinib combination therapy: a case report
Jing Zhao, Ming Zou, Jinyan Lv, Yingmin Han, Guangzhi Wang & Gang Wang
Pages: 5545-5550
Published online: 06 Sep 2018
AbstractforEffective treatment of pulmonary adenocarcinoma harboring triple EGFR mutations of L858R, T790M, and cis-C797S by osimertinib, bevacizumab, and brigatinib combination therapy: a case report | Full Text | References | PDF (1.9 MB)
  • 146 Views
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Original Research

Article
Negative correlation of cytoplasm TIMP3 with miR-222 indicates a good prognosis for NSCLC
Yiyan Lei, Zhaoguo Liu & Weilin Yang
Pages: 5551-5557
Published online: 06 Sep 2018
AbstractforNegative correlation of cytoplasm TIMP3 with miR-222 indicates a good prognosis for NSCLC | Full Text | References | PDF (1.7 MB)
  • 61 Views
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Article
CXCR2 is a novel cancer stem-like cell marker for triple-negative breast cancer
Yuyi Wang, Li Tu, Chi Du, Xiaoxiao Xie, Yanyang Liu, Jiantao Wang, Zhixi Li, Ming Jiang, Dan Cao, Xi Yan & Feng Luo
Pages: 5559-5567
Published online: 06 Sep 2018
AbstractforCXCR2 is a novel cancer stem-like cell marker for triple-negative breast cancer | Full Text | References | PDF (11 MB)
  • 132 Views
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Article
Hsa_circ_0003998 promotes cell proliferation and invasion by targeting miR-326 in non-small cell lung cancer
Wanjun Yu, Hao Jiang, Huihui Zhang & Jipeng Li
Pages: 5569-5577
Published online: 07 Sep 2018
AbstractforHsa_circ_0003998 promotes cell proliferation and invasion by targeting miR-326 in non-small cell lung cancer | Full Text | References | PDF (1.5 MB)
  • 54 Views
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Article
RRM1 expression and the clinicopathological characteristics of patients with non-small cell lung cancer treated with gemcitabine
Ying Chen, Ying Huang, Dong-Ming Chen, Chao Wu, Qiu-Ping Leng, Wen-Yi Wang, Ming-Qin Deng, Yan-Xia Zhao & Xiao-Hong Yang
Pages: 5579-5589
Published online: 07 Sep 2018
AbstractforRRM1 expression and the clinicopathological characteristics of patients with non-small cell lung cancer treated with gemcitabine | Full Text | References | PDF (1.3 MB)
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Article
Preoperative high-sensitivity C-reactive protein to lymphocyte ratio index plays a vital role in the prognosis of hepatocellular carcinoma after surgical resection
Minjun Liao, Pu Chen, Yan Liao, Jun Li, Wenmin Yao, Tian Sun, Weijia Liao & Lili Su
Pages: 5591-5600
Published online: 07 Sep 2018
AbstractforPreoperative high-sensitivity C-reactive protein to lymphocyte ratio index plays a vital role in the prognosis of hepatocellular carcinoma after surgical resection | Full Text | References | PDF (1.8 MB)
  • 64 Views
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Case Report

Case Report
Pembrolizumab and salvage chemotherapy in EGFR T790M-positive non-small-cell lung cancer with high PD-L1 expression
Takehiro Tozuka, Masahiro Seike, Yuji Minegishi, Shingo Kitagawa, Tomomi Kato, Natsuki Takano, Kakeru Hisakane, Satoshi Takahashi, Kenichi Kobayashi, Takeru Kashiwada, Teppei Sugano, Susumu Takeuchi, Shinobu Kunugi, Rintaro Noro, Yoshinobu Saito, Kaoru Kubota & Akihiko Gemma
Pages: 5601-5605
Published online: 07 Sep 2018
AbstractforPembrolizumab and salvage chemotherapy in EGFR T790M-positive non-small-cell lung cancer with high PD-L1 expression | Full Text | References | PDF (1.7 MB)
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Original Research

Article
Podoplanin-positive cancer-associated fibroblasts predict poor prognosis in lung cancer patients
Guoming Hu, Kefang Zhong, Wei Chen, Shimin Wang & Liming Huang
Pages: 5607-5619
Published online: 10 Sep 2018
AbstractforPodoplanin-positive cancer-associated fibroblasts predict poor prognosis in lung cancer patients | Full Text | References | PDF (1.3 MB)
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Article
Low-frequency ultrasound enhances chemotherapy sensitivity and induces autophagy in PTX-resistant PC-3 cells via the endoplasmic reticulum stress-mediated PI3K/Akt/mTOR signaling pathway
Yuqi Wu, Xiaobing Liu, Zizhen Qin, Li Hu & Xiangwei Wang
Pages: 5621-5630
Published online: 10 Sep 2018
AbstractforLow-frequency ultrasound enhances chemotherapy sensitivity and induces autophagy in PTX-resistant PC-3 cells via the endoplasmic reticulum stress-mediated PI3K/Akt/mTOR signaling pathway | Full Text | References | PDF (11 MB)
  • 150 Views
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Article
The downregulated long noncoding RNA DHRS4-AS1 is protumoral and associated with the prognosis of clear cell renal cell carcinoma
Changlin Wang, Gang Wang, Zijian Zhang, Zichun Wang, Minghua Ren, Xiaoxiong Wang, Haoming Li, Yipeng Yu, Jing Liu, Licheng Cai, Yong Li, Daming Zhang & Cheng Zhang
Pages: 5631-5646
Published online: 10 Sep 2018
AbstractforThe downregulated long noncoding RNA DHRS4-AS1 is protumoral and associated with the prognosis of clear cell renal cell carcinoma | Full Text | References | PDF (3.8 MB)
  • 74 Views
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Article
Upregulation of long noncoding RNA CCAT1-L promotes epithelial–mesenchymal transition in gastric adenocarcinoma
Hua Fang, Hui-Min Liu, Wei-Hua Wu, Han Liu, Yong Pan & Wen-Jun Li
Pages: 5647-5655
Published online: 10 Sep 2018
AbstractforUpregulation of long noncoding RNA CCAT1-L promotes epithelial–mesenchymal transition in gastric adenocarcinoma | Full Text | References | PDF (2 MB)
  • 54 Views
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Article
MicroRNA-300 suppresses metastasis of oral squamous cell carcinoma by inhibiting epithelial-to-mesenchymal transition
Yuanyuan Kang, Ying Zhang, Yan Sun, Yan Wen & Fuli Sun
Pages: 5657-5666
Published online: 10 Sep 2018
AbstractforMicroRNA-300 suppresses metastasis of oral squamous cell carcinoma by inhibiting epithelial-to-mesenchymal transition | Full Text | References | PDF (3.3 MB)
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Review

Review Article
The role of gene sculptor microRNAs in human precancerous lesions
Ran-Hong Wang, Lan-Ying He & Shui-Hong Zhou
Pages: 5667-5675
Published online: 10 Sep 2018
AbstractforThe role of gene sculptor microRNAs in human precancerous lesions | Full Text | References | PDF (3.2 MB)
  • 76 Views
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Original Research

Article
A correlation study of the expression of HA-CD44st and HER-2 in breast cancer
Lu Ying Zhi, Zhang Xu, Li Ning, Li Jia Jin, Yan Hai Cui, Huang Guan Hong & Xin Jian Fang
Pages: 5677-5688
Published online: 10 Sep 2018
AbstractforA correlation study of the expression of HA-CD44st and HER-2 in breast cancer | Full Text | References | PDF (2.2 MB)
  • 63 Views
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Article
Volatile anesthetic sevoflurane suppresses lung cancer cells and miRNA interference in lung cancer cells
Le Wang, Tiao Wang, Jia-Qi Gu & Hui-Bin Su
Pages: 5689-5693
Published online: 11 Sep 2018
AbstractforVolatile anesthetic sevoflurane suppresses lung cancer cells and miRNA interference in lung cancer cells | Full Text | References | PDF (523.2 KB)
  • 84 Views
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Article
NEAT1_2–SFPQ axis mediates cisplatin resistance in liver cancer cells in vitro
Yi Ru, Xiao-Jie Chen, Wen-Zhi Guo, She-Gan Gao, Yi-Jun Qi, Pan Chen, Xiao-Shan Feng & Shui-Jun Zhang
Pages: 5695-5702
Published online: 11 Sep 2018
AbstractforNEAT1_2–SFPQ axis mediates cisplatin resistance in liver cancer cells in vitro | Full Text | References | PDF (1.8 MB)
  • 104 Views
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Article
Helicobacter pylori promotes gastric epithelial cell survival through the PLK1/PI3K/Akt pathway
Wenting Xu, Ying Huang, Zhen Yang, Yi Hu, Xu Shu, Chuan Xie, Cong He, Yin Zhu & Nonghua Lu
Pages: 5703-5713
Published online: 11 Sep 2018
AbstractforHelicobacter pylori promotes gastric epithelial cell survival through the PLK1/PI3K/Akt pathway | Full Text | References | PDF (11.1 MB)
  • 82 Views
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Case Series

The incidence and risk factors of hepatotoxicity induced by perioperative hyperthermic intraperitoneal chemotherapy in gastrointestinal carcinoma patients: a retrospective study
Zhewen Zheng, Haijun Yu, Bin Xiong, Shuangting Shen, Hui Yang & Yunfeng Zhou
Pages: 5715-5722
Published online: 14 Nov 2022
AbstractforThe incidence and risk factors of hepatotoxicity induced by perioperative hyperthermic intraperitoneal chemotherapy in gastrointestinal carcinoma patients: a retrospective study | Full Text | References | PDF (304.4 KB)
  • 45 Views
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Original Research

Article
IL-8 regulates the stemness properties of cancer stem cells in the small-cell lung cancer cell line H446
Fang Jin, Yajing Miao, Pengyu Xu & Xiaofei Qiu
Pages: 5723-5731
Published online: 11 Sep 2018
AbstractforIL-8 regulates the stemness properties of cancer stem cells in the small-cell lung cancer cell line H446 | Full Text | References | PDF (4.2 MB)
  • 95 Views
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Article
SOX5 induces lung adenocarcinoma angiogenesis by inducing the expression of VEGF through STAT3 signaling
Xin Chen, Qi Zheng, Weidong Li, Yuan Lu, Yiming Ni, Liang Ma & Yufei Fu
Pages: 5733-5741
Published online: 11 Sep 2018
AbstractforSOX5 induces lung adenocarcinoma angiogenesis by inducing the expression of VEGF through STAT3 signaling | Full Text | References | PDF (2.5 MB)
  • 83 Views
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Article
Long noncoding RNA SNHG6 promotes the progression of colorectal cancer through sponging miR-760 and activation of FOXC1
Yuekun Zhu, Yanwei Xing, Fengxu Chi, Weidong Sun, Zhiyong Zhang & Daxun Piao
Pages: 5743-5752
Published online: 14 Nov 2022
AbstractforLong noncoding RNA SNHG6 promotes the progression of colorectal cancer through sponging miR-760 and activation of FOXC1 | Full Text | References | PDF (1.9 MB)
  • 65 Views
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Article
Targeted cancer therapy using engineered exosome as a natural drug delivery vehicle
Hosna Gomari, Mehdi Forouzandeh Moghadam & Masoud Soleimani
Pages: 5753-5762
Published online: 14 Nov 2022
AbstractforTargeted cancer therapy using engineered exosome as a natural drug delivery vehicle | Full Text | References | PDF (7.3 MB)
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Review

Review Article
Ultrasound-mediated microbubble destruction: a new method in cancer immunotherapy
Jiawei Tu, Hui Zhang, Jinsui Yu, Chun Liufu & Zhiyi Chen
Pages: 5763-5775
Published online: 12 Sep 2018
AbstractforUltrasound-mediated microbubble destruction: a new method in cancer immunotherapy | Full Text | References | PDF (2.2 MB)
  • 213 Views
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Original Research

Article
Combined detection of IL-6 and IL-8 is beneficial to the diagnosis of early stage esophageal squamous cell cancer: a preliminary study based on the screening of serum markers using protein chips
Qiang Tong, Xiao-long Wang, Sheng-bao Li, Gong-li Yang, Shu Jin, Zi-ye Gao & Xiao-bo Liu
Pages: 5777-5787
Published online: 12 Sep 2018
AbstractforCombined detection of IL-6 and IL-8 is beneficial to the diagnosis of early stage esophageal squamous cell cancer: a preliminary study based on the screening of serum markers using protein chips | Full Text | References | PDF (1.2 MB)
  • 99 Views
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Article
Association of GSTP1 and P16 promoter methylation with the risk of HBV-related hepatocellular carcinoma: a meta-analysis
Qin Li, Cunliang Deng, Ting Zhang & Xiang Li
Pages: 5789-5796
Published online: 14 Nov 2022
AbstractforAssociation of GSTP1 and P16 promoter methylation with the risk of HBV-related hepatocellular carcinoma: a meta-analysis | Full Text | References | PDF (1.2 MB)
  • 51 Views
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Article
PPP5C promotes cell proliferation and survival in human prostate cancer by regulating of the JNK and ERK1/2 phosphorylation
Jian-Min Lv, Lu Chen, Yi Gao, Hai Huang, Xiu-Wu Pan, Xi Liu, Ming Chen, Fa-Jun Qu, Lin Li, Jun-Kai Wang, Xin-Gang Cui & Dan-Feng Xu
Pages: 5797-5809
Published online: 12 Sep 2018
AbstractforPPP5C promotes cell proliferation and survival in human prostate cancer by regulating of the JNK and ERK1/2 phosphorylation | Full Text | References | PDF (9.6 MB)
  • 91 Views
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Article
Subgroup analysis reveals molecular heterogeneity and provides potential precise treatment for pancreatic cancers
Heying Zhang, Juan Zeng, Yongqiang Tan, Lin Lu, Cheng Sun, Yusi Liang, Huawei Zou, Xianghong Yang & Yonggang Tan
Pages: 5811-5819
Published online: 14 Nov 2022
AbstractforSubgroup analysis reveals molecular heterogeneity and provides potential precise treatment for pancreatic cancers | Full Text | References | PDF (4.7 MB)
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Case Report

Case Report
Apatinib combined with docetaxel as a salvage treatment for metastatic esophageal squamous cancer: a case report
Li-Jun Liang, Yi-Xuan Wen, You-You Xia, Lei Wang, Jia-Yan Fei & Xiao-Dong Jiang
Pages: 5821-5826
Published online: 13 Sep 2018
AbstractforApatinib combined with docetaxel as a salvage treatment for metastatic esophageal squamous cancer: a case report | Full Text | References | PDF (2.2 MB)
  • 50 Views
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Original Research

Article
Combination of carcinoembryonic antigen with the American Joint Committee on Cancer TNM staging system in rectal cancer: a real-world and large population-based study
Qi Liu, Peng Lian, Dakui Luo, Sanjun Cai, Qingguo Li & Xinxiang Li
Pages: 5827-5834
Published online: 13 Sep 2018
AbstractforCombination of carcinoembryonic antigen with the American Joint Committee on Cancer TNM staging system in rectal cancer: a real-world and large population-based study | Full Text | References | PDF (715.5 KB)
  • 53 Views
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Article
TMEM119 promotes gastric cancer cell migration and invasion through STAT3 signaling pathway
Peifen Zheng, Weifeng Wang, Muxi Ji, Qin Zhu, Yuliang Feng, Feng Zhou & Qiaona He
Pages: 5835-5844
Published online: 13 Sep 2018
AbstractforTMEM119 promotes gastric cancer cell migration and invasion through STAT3 signaling pathway | Full Text | References | PDF (2.3 MB)
  • 154 Views
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Article
Long-term response to first-line bevacizumab-based therapy in patients with metastatic breast cancer: results of the observational “LORENA” study
Andrés Redondo, Manuel Ramos Vázquez, Luis Manso, Miguel J Gil Gil, Isabel Garau Llinas, Elisa García-Garre, César A Rodríguez, José Ignacio Chacón & Guillermo López-Vivanco
Pages: 5845-5852
Published online: 17 Sep 2018
AbstractforLong-term response to first-line bevacizumab-based therapy in patients with metastatic breast cancer: results of the observational “LORENA” study | Full Text | References | PDF (729 KB)
  • 71 Views
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Article
DACH1 inhibits glioma invasion and tumor growth via the Wnt/catenin pathway
Jing Wang, Yan Zou, Xuechao Wu, Mu Chen, Shuai Zhang, Xiaojie Lu & Qing Wang
Pages: 5853-5863
Published online: 17 Sep 2018
AbstractforDACH1 inhibits glioma invasion and tumor growth via the Wnt/catenin pathway | Full Text | References | PDF (2.3 MB)
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Article
Evaluation of supportive and barrier-protective skin care products in the daily prevention and treatment of cutaneous toxicity during systemic chemotherapy
Diana Lüftner, Veronica Dell’Acqua, Frédéric Selle, Ahmed Khalil, Maria Cristina Leonardi, Alejandro De La Torre Tomás, George Shenouda, Jesus Romero Fernandez, Roberto Orecchia, Dominique Moyal & Sophie Seité
Pages: 5865-5872
Published online: 17 Sep 2018
AbstractforEvaluation of supportive and barrier-protective skin care products in the daily prevention and treatment of cutaneous toxicity during systemic chemotherapy | Full Text | References | PDF (695.5 KB)
  • 212 Views
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Article
Estrogen affects cell growth and IGF-1 receptor expression in renal cell carcinoma
Lijiang Sun, Zhemin Gao, Lei Luo, Hailin Tan & Guiming Zhang
Pages: 5873-5878
Published online: 17 Sep 2018
AbstractforEstrogen affects cell growth and IGF-1 receptor expression in renal cell carcinoma | Full Text | References | PDF (1.2 MB)
  • 88 Views
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Case Series

Case Report
A case of interstitial lung disease with alveolar hemorrhage induced by pembrolizumab
Teppei Sugano, Masahiro Seike, Rintaro Noro, Syota Kaburaki, Takehiro Tozuka, Akihiko Takahashi, Natsuki Takano, Toru Tanaka, Takeru Kashiwada, Susumu Takeuchi, Yuji Minegishi, Yoshinobu Saito, Kaoru Kubota, Yasuhiro Terasaki & Akihiko Gemma
Pages: 5879-5883
Published online: 17 Sep 2018
AbstractforA case of interstitial lung disease with alveolar hemorrhage induced by pembrolizumab | Full Text | References | PDF (2.6 MB)
  • 75 Views
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Original Research

Article
MicroRNA-140-3p enhances the sensitivity of hepatocellular carcinoma cells to sorafenib by targeting pregnenolone X receptor
Jiaqi Li, Jing Zhao, Huan Wang, Xiaohan Li, Aixia Liu, Qin Qin & Boan Li
Pages: 5885-5894
Published online: 17 Sep 2018
AbstractforMicroRNA-140-3p enhances the sensitivity of hepatocellular carcinoma cells to sorafenib by targeting pregnenolone X receptor | Full Text | References | PDF (1.7 MB)
  • 72 Views
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Article
Elevated urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine and serum uric acid are associated with progression and are prognostic factors of colorectal cancer
Lingna Mao, Cheng Guo & Shu Zheng
Pages: 5895-5902
Published online: 17 Sep 2018
AbstractforElevated urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine and serum uric acid are associated with progression and are prognostic factors of colorectal cancer | Full Text | References | PDF (720.5 KB)
  • 68 Views
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Article
Laparoscopic procedure compared with open radical hysterectomy with pelvic lymphadenectomy in early cervical cancer: a retrospective study
Jianfeng Guo, Lu Yang, Jing Cai, Linjuan Xu, Jie Min, Yi Shen, Zhoufang Xiong, Weihong Dong, Vichitra Bunyamanop & Zehua Wang
Pages: 5903-5908
Published online: 18 Sep 2018
AbstractforLaparoscopic procedure compared with open radical hysterectomy with pelvic lymphadenectomy in early cervical cancer: a retrospective study | Full Text | References | PDF (644.7 KB)
  • 58 Views
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Review

Review Article
Therapy-related myeloid neoplasms: clinical perspectives
Luana Fianchi, Marianna Criscuolo, Emiliano Fabiani, Giulia Falconi, Alessio Maria Edoardo Maraglino, Maria Teresa Voso & Livio Pagano
Pages: 5909-5915
Published online: 17 Sep 2018
AbstractforTherapy-related myeloid neoplasms: clinical perspectives | Full Text | References | PDF (246.1 KB)
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Original Research

Article
Lipoprotein (a): a promising prognostic biomarker in patients with hepatocellular carcinoma after curative resection
Xing-hui Gao, Shuang-shuang Zhang, Hao Chen, Kun Wang, Wen Xie & Fu-Bing Wang
Pages: 5917-5924
Published online: 17 Sep 2018
AbstractforLipoprotein (a): a promising prognostic biomarker in patients with hepatocellular carcinoma after curative resection | Full Text | References | PDF (1.4 MB)
  • 47 Views
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Case Report

Case Report
Successful treatment of recurrent rectal implantation metastasis of ovarian cancer by natural orifice specimen extraction surgery: a case report
Hao Su, Bin Li, Wenhao Ren, Mandula Bao, Peng Wang, Qian Liu, Xishan Wang, Zhixiang Zhou & Haitao Zhou
Pages: 5925-5931
Published online: 17 Sep 2018
AbstractforSuccessful treatment of recurrent rectal implantation metastasis of ovarian cancer by natural orifice specimen extraction surgery: a case report | Full Text | References | PDF (2.5 MB)
  • 68 Views
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Original Research

Article
Osteopontin promotes cancer cell drug resistance, invasion, and lactate production and is associated with poor outcome of patients with advanced non-small-cell lung cancer
Xiaoping Ouyang, Yumin Huang, Xing Jin, Wei Zhao, Tao Hu, Feng Wu & Jianan Huang
Pages: 5933-5941
Published online: 14 Nov 2022
AbstractforOsteopontin promotes cancer cell drug resistance, invasion, and lactate production and is associated with poor outcome of patients with advanced non-small-cell lung cancer | Full Text | References | PDF (3 MB)
  • 200 Views
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Article
Identification of the predictive genes for the response of colorectal cancer patients to FOLFOX therapy
Hengjun Lin, Xueke Qiu, Bo Zhang & Jichao Zhang
Pages: 5943-5955
Published online: 17 Sep 2018
AbstractforIdentification of the predictive genes for the response of colorectal cancer patients to FOLFOX therapy | Full Text | References | PDF (1.8 MB)
  • 106 Views
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Case Report

Case Report
Treatment with olaparib monotherapy for BRCA2-mutated refractory intrahepatic cholangiocarcinoma: a case report
Yuan Cheng, Juan Zhang, Shu kui Qin & Hai qing Hua
Pages: 5957-5962
Published online: 14 Nov 2022
AbstractforTreatment with olaparib monotherapy for BRCA2-mutated refractory intrahepatic cholangiocarcinoma: a case report | Full Text | References | PDF (873.9 KB)
  • 147 Views
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Original Research

Article
TLR9 signaling activation at different stages in colorectal cancer and NF-kappaB expression
Caixia Gao, Tiankui Qiao, Bin Zhang, Sujuan Yuan, Xibing Zhuang & Youjun Luo
Pages: 5963-5971
Published online: 18 Sep 2018
AbstractforTLR9 signaling activation at different stages in colorectal cancer and NF-kappaB expression | Full Text | References | PDF (1.6 MB)
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Review

Review Article
PD1/PDL1 inhibitors for the treatment of advanced urothelial bladder cancer
David D Stenehjem, Dao Tran, Michael A Nkrumah & Shilpa Gupta
Pages: 5973-5989
Published online: 19 Sep 2018
AbstractforPD1/PDL1 inhibitors for the treatment of advanced urothelial bladder cancer | Full Text | References | PDF (991.9 KB)
  • 290 Views
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Original Research

Article
Prognostic value of miR-17-5 p in gastrointestinal cancers: a systematic review and meta-analysis
Zeyu Wang, Jing Zhang, Zhiguang Zhang, Yong Jiang, Man Li, Qian Li, Lu Bai, Dongying Yao, Miao Wang & Xiaoping Wang
Pages: 5991-5999
Published online: 19 Sep 2018
AbstractforPrognostic value of miR-17-5 p in gastrointestinal cancers: a systematic review and meta-analysis | Full Text | References | PDF (1.1 MB)
  • 64 Views
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Article
Application of weighted gene co-expression network analysis to identify key modules and hub genes in oral squamous cell carcinoma tumorigenesis
Xiaoqi Zhang, Hao Feng, Ziyu Li, Dongfang Li, Shanshan Liu, Haiyun Huang & Minqi Li
Pages: 6001-6021
Published online: 19 Sep 2018
AbstractforApplication of weighted gene co-expression network analysis to identify key modules and hub genes in oral squamous cell carcinoma tumorigenesis | Full Text | References | PDF (7.3 MB)
  • 277 Views
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Article
The predictive ability of plasma ESR1 mutations for the efficacy of endocrine therapy in hormone-receptor-positive advanced breast cancer
Yangfan Du, Na Li, Xin Jiao, Kai Li & Shunchao Yan
Pages: 6023-6029
Published online: 19 Sep 2018
AbstractforThe predictive ability of plasma ESR1 mutations for the efficacy of endocrine therapy in hormone-receptor-positive advanced breast cancer | Full Text | References | PDF (641.1 KB)
  • 84 Views
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Article
Oldhamianoside inhibits the growth of ovarian cancer both in vitro and in vivo via adjusting inflammation and angiogenesis signals
Zenghui Li, Ying Zuo, Li Hou, Liangliang Dong & Xiaomei Sun
Pages: 6031-6037
Published online: 19 Sep 2018
AbstractforOldhamianoside inhibits the growth of ovarian cancer both in vitro and in vivo via adjusting inflammation and angiogenesis signals | Full Text | References | PDF (1.1 MB)
  • 59 Views
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Article
Phenformin and metformin inhibit growth and migration of LN229 glioma cells in vitro and in vivo
Yanmin Wang, Yanli Meng, Shijun Zhang, Huancheng Wu, Dawei Yang, Chaohui Nie & Qunliang Hu
Pages: 6039-6048
Published online: 20 Sep 2018
AbstractforPhenformin and metformin inhibit growth and migration of LN229 glioma cells in vitro and in vivo | Full Text | References | PDF (2.2 MB)
  • 102 Views
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Article
Upregulation of the alternative splicing factor NOVA2 in colorectal cancer vasculature
Stefania Gallo, Maria Vittoria Arcidiacono, Veronica Tisato, Roberta Piva, Letizia Penolazzi, Cristina Bosi, Carlo V Feo, Roberta Gafà & Paola Secchiero
Pages: 6049-6056
Published online: 20 Sep 2018
AbstractforUpregulation of the alternative splicing factor NOVA2 in colorectal cancer vasculature | Full Text | References | PDF (2.6 MB)
  • 74 Views
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Review

Review Article
Comparison of short-term outcomes between minimally invasive McKeown and Ivor Lewis esophagectomy for esophageal or junctional cancer: a systematic review and meta-analysis
Jianqing Deng, Qingqing Su, Zhipeng Ren, Jiaxin Wen, Zhiqiang Xue, Lianbin Zhang & Xiangyang Chu
Pages: 6057-6069
Published online: 20 Sep 2018
AbstractforComparison of short-term outcomes between minimally invasive McKeown and Ivor Lewis esophagectomy for esophageal or junctional cancer: a systematic review and meta-analysis | Full Text | References | PDF (1.1 MB)
  • 99 Views
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Original Research

Article
LINK-A promotes cell proliferation through the regulation of aerobic glycolysis in non-small-cell lung cancer
Wei Zhao, Wancheng Li, Wenjing Dai, Na Huang & Jing Qiu
Pages: 6071-6080
Published online: 14 Nov 2022
AbstractforLINK-A promotes cell proliferation through the regulation of aerobic glycolysis in non-small-cell lung cancer | Full Text | References | PDF (2.1 MB)
  • 71 Views
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Article
SNHG8 is identified as a key regulator in non-small-cell lung cancer progression sponging to miR-542-3p by targeting CCND1/CDK6
Changhao Chen, Zhiwei Zhang, Jie Li & Yuejun Sun
Pages: 6081-6090
Published online: 20 Sep 2018
AbstractforSNHG8 is identified as a key regulator in non-small-cell lung cancer progression sponging to miR-542-3p by targeting CCND1/CDK6 | Full Text | References | PDF (1.3 MB)
  • 72 Views
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Article
Efficacy and safety of trastuzumab as maintenance or palliative therapy in advanced HER2-positive gastric cancer
Xiaomin Fu, Yong Zhang, Jing Yang, Yalong Qi, Yue Ming, Miaomiao Sun, Yiman Shang, Yonghao Yang, Xiaoyan Zhu & Quanli Gao
Pages: 6091-6100
Published online: 20 Sep 2018
AbstractforEfficacy and safety of trastuzumab as maintenance or palliative therapy in advanced HER2-positive gastric cancer | Full Text | References | PDF (1.9 MB)
  • 115 Views
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Article
Lentivirus-mediated shRNA targeting MUTYH inhibits malignant phenotypes of bladder cancer SW780 cells
Qunjun Gao, Yuhan Liu, Haibiao Xie, Yucheng Zhong, Xinhui Liao, Hengji Zhan, Qun Zhou, Mengting Ding, Kang Yang, Aolin Li, Yuchen Liu, Hongbing Mei & Zhiming Cai
Pages: 6101-6109
Published online: 21 Sep 2018
AbstractforLentivirus-mediated shRNA targeting MUTYH inhibits malignant phenotypes of bladder cancer SW780 cells | Full Text | References | PDF (6.6 MB)
  • 77 Views
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Article
Dual inhibitor of PI3K and mTOR (NVP-BEZ235) augments the efficacy of fluorouracil on gastric cancer chemotherapy
Liangqing Li, Shengwei Zhang, Diya Xie, Hui Chen, Xuelan Zheng & Dun Pan
Pages: 6111-6118
Published online: 20 Sep 2018
AbstractforDual inhibitor of PI3K and mTOR (NVP-BEZ235) augments the efficacy of fluorouracil on gastric cancer chemotherapy | Full Text | References | PDF (2.5 MB)
  • 68 Views
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Review

Review Article
Efficacy and safety of apatinib treatment for gastric cancer, hepatocellular carcinoma and non-small cell lung cancer: a meta-analysis
Jin-min Xue, Manirakiza Astère, Mao-xi Zhong, Han Lin, Jin Shen & Yu-xi Zhu
Pages: 6119-6128
Published online: 21 Sep 2018
AbstractforEfficacy and safety of apatinib treatment for gastric cancer, hepatocellular carcinoma and non-small cell lung cancer: a meta-analysis | Full Text | References | PDF (899.4 KB)
  • 91 Views
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Original Research

Article
Is long interval from neoadjuvant chemoradiotherapy to surgery optimal for rectal cancer in the era of intensity-modulated radiotherapy?: a prospective observational study
Hui Chang, Wu Jiang, Wei-Jun Ye, Ya-Lan Tao, Qiao-Xuan Wang, Wei-Wei Xiao & Yuan-Hong Gao
Pages: 6129-6138
Published online: 21 Sep 2018
AbstractforIs long interval from neoadjuvant chemoradiotherapy to surgery optimal for rectal cancer in the era of intensity-modulated radiotherapy?: a prospective observational study | Full Text | References | PDF (831.9 KB)
  • 75 Views
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Article
Distribution of CD4+ and CD8+ exhausted tumor-infiltrating lymphocytes in molecular subtypes of Chinese breast cancer patients
Feng Shi, Hong Chang, Quan Zhou, Yan-Jie Zhao, Guang-Jiang Wu & Qing-Kun Song
Pages: 6139-6145
Published online: 21 Sep 2018
AbstractforDistribution of CD4+ and CD8+ exhausted tumor-infiltrating lymphocytes in molecular subtypes of Chinese breast cancer patients | Full Text | References | PDF (3.9 MB)
  • 96 Views
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Case Report

Case Report
Scalp metastases as first presentation of pulmonary adenocarcinomas: a case report
Qian Yu, Smriti Subedi, Yunlei Tong, Qing Wei, Hui Xu, Yao Wang, Yu Gong & Yuling Shi
Pages: 6147-6151
Published online: 21 Sep 2018
AbstractforScalp metastases as first presentation of pulmonary adenocarcinomas: a case report | Full Text | References | PDF (3.5 MB)
  • 78 Views
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Original Research

Article
CPEB4 promotes growth and metastasis of gastric cancer cells via ZEB1-mediated epithelial– mesenchymal transition
Gan Cao, Dehu Chen, Guiyuan Liu, Yan Pan & Qinghong Liu
Pages: 6153-6165
Published online: 21 Sep 2018
AbstractforCPEB4 promotes growth and metastasis of gastric cancer cells via ZEB1-mediated epithelial– mesenchymal transition | Full Text | References | PDF (3.6 MB)
  • 81 Views
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Article
Clinical, dosimetric, and position factors for radiation-induced acute esophagitis in intensity-modulated (chemo)radiotherapy for locally advanced non-small-cell lung cancer
Jin Huang, Tianyu He, Ronghui Yang, Tianlong Ji & Guang Li
Pages: 6167-6175
Published online: 21 Sep 2018
AbstractforClinical, dosimetric, and position factors for radiation-induced acute esophagitis in intensity-modulated (chemo)radiotherapy for locally advanced non-small-cell lung cancer | Full Text | References | PDF (858.1 KB)
  • 75 Views
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Article
All-trans retinoic acid-encapsulated, CD20 antibody-conjugated poly(lactic-co-glycolic acid) nanoparticles effectively target and eliminate melanoma-initiating cells in vitro
Xingyu Chen, Zhiyuan Zhang, Shengfeng Yang, Hairong Chen, Dan Wang & Jun Li
Pages: 6177-6187
Published online: 25 Sep 2018
AbstractforAll-trans retinoic acid-encapsulated, CD20 antibody-conjugated poly(lactic-co-glycolic acid) nanoparticles effectively target and eliminate melanoma-initiating cells in vitro | Full Text | References | PDF (5.2 MB)
  • 66 Views
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Review

Review Article
Immunotherapy combined with epidermal growth factor receptor-tyrosine kinase inhibitors in non-small-cell lung cancer treatment
Hongge Liang, Xiaoyan Liu & Mengzhao Wang
Pages: 6189-6196
Published online: 25 Sep 2018
AbstractforImmunotherapy combined with epidermal growth factor receptor-tyrosine kinase inhibitors in non-small-cell lung cancer treatment | Full Text | References | PDF (299.7 KB)
  • 131 Views
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Original Research

Article
SOX2, a stemness gene, induces progression of NSCLC A549 cells toward anchorage-independent growth and chemoresistance to vinblastine
Chungyoul Choe, Hyewon Kim, Sol Min, Sangkyu Park, Jeongmin Seo & Sangho Roh
Pages: 6197-6207
Published online: 14 Nov 2022
AbstractforSOX2, a stemness gene, induces progression of NSCLC A549 cells toward anchorage-independent growth and chemoresistance to vinblastine | Full Text | References | PDF (1.9 MB)
  • 141 Views
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Article
CAV2 promotes the growth of renal cell carcinoma through the EGFR/PI3K/Akt pathway
Fu Liu, Zhi Shangli & Zhili Hu
Pages: 6209-6216
Published online: 25 Sep 2018
AbstractforCAV2 promotes the growth of renal cell carcinoma through the EGFR/PI3K/Akt pathway | Full Text | References | PDF (3.7 MB)
  • 74 Views
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Article
MicroRNA-671-3p promotes proliferation and migration of glioma cells via targeting CKAP4
Gui-Feng Lu, Chun-Yue You, Yuan-Shou Chen, Hui Jiang, Xiang Zheng, Wei-Wei Tang, Xian-Yan Wang, Hai-Yan Xu & Fei Geng
Pages: 6217-6226
Published online: 25 Sep 2018
AbstractforMicroRNA-671-3p promotes proliferation and migration of glioma cells via targeting CKAP4 | Full Text | References | PDF (11.3 MB)
  • 89 Views
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Review

Review Article
Mechanisms, monitoring, and management of tyrosine kinase inhibitors–associated cardiovascular toxicities
Maher Chaar, Jeff Kamta & Sihem Ait-Oudhia
Pages: 6227-6237
Published online: 25 Sep 2018
AbstractforMechanisms, monitoring, and management of tyrosine kinase inhibitors–associated cardiovascular toxicities | Full Text | References | PDF (768 KB)
  • 316 Views
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Original Research

Article
PLK1 as a potential prognostic marker of gastric cancer through MEK-ERK pathway on PDTX models
Sheng-Chun Dang, Yi-Yi Fan, Lei Cui, Ji-Xiang Chen, Jian-Guo Qu & Min Gu
Pages: 6239-6247
Published online: 25 Sep 2018
AbstractforPLK1 as a potential prognostic marker of gastric cancer through MEK-ERK pathway on PDTX models | Full Text | References | PDF (4.9 MB)
  • 64 Views
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Article
Overexpression of GPR35 confers drug resistance in NSCLC cells by β-arrestin/Akt signaling
Wei Wang, Tianci Han, Wei Tong, Jian Zhao & Xueshan Qiu
Pages: 6249-6257
Published online: 26 Sep 2018
AbstractforOverexpression of GPR35 confers drug resistance in NSCLC cells by β-arrestin/Akt signaling | Full Text | References | PDF (2.4 MB)
  • 107 Views
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Article
RETRACTED ARTICLE: Effect of long non-coding RNA AOC4P on gastrointestinal stromal tumor cells
Jin-Chen Hu, Quan Wang, Li-Xin Jiang, Li Cai, Hui-Yuan Zhai, Zeng-Wu Yao, Meng-Lai Zhang & Ye Feng
Pages: 6259-6269
Published online: 26 Sep 2018
AbstractforRETRACTED ARTICLE: Effect of long non-coding RNA AOC4P on gastrointestinal stromal tumor cells | PDF (5.6 MB)
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Case Report

Case Report
POEMS syndrome complicated with multiple ischemic vascular events: case report and review of literature
Mihaela Găman, Ana-Maria Vlădăreanu, Camelia Dobrea, Minodora Onisâi, Cristina Marinescu, Diana Cîşleanu, Cristina Ciufu, Daniela Vasile, Horia Bumbea & Irina Voican
Pages: 6271-6276
Published online: 27 Sep 2018
AbstractforPOEMS syndrome complicated with multiple ischemic vascular events: case report and review of literature | Full Text | References | PDF (546.6 KB)
  • 65 Views
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Original Research

Article
Metabolic syndrome and the incidence of hepatocellular carcinoma: a meta-analysis of cohort studies
Yongxin Chen, Xiaofei Li, Shuang Wu, Weiwei Ye & Lianqing Lou
Pages: 6277-6285
Published online: 14 Nov 2022
AbstractforMetabolic syndrome and the incidence of hepatocellular carcinoma: a meta-analysis of cohort studies | Full Text | References | PDF (853.1 KB)
  • 64 Views
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Article
Predictive value of LDH kinetics in bevacizumab treatment and survival of patients with advanced NSCLC
Butuo Li, Cheng Li, Meiying Guo, Shuheng Shang, Xiaogang Li, Peng Xie, Xindong Sun, Jinming Yu & Linlin Wang
Pages: 6287-6294
Published online: 14 Nov 2022
AbstractforPredictive value of LDH kinetics in bevacizumab treatment and survival of patients with advanced NSCLC | Full Text | References | PDF (3.6 MB)
  • 96 Views
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Article
RETRACTED ARTICLE: LINC00152 promotes the growth and invasion of oral squamous cell carcinoma by regulating miR-139-5p
Minghe Li, Jun Ning, Zhihong Li, Jing Wang, Cong Zhao & Lei Wang
Pages: 6295-6304
Published online: 27 Sep 2018
AbstractforRETRACTED ARTICLE: LINC00152 promotes the growth and invasion of oral squamous cell carcinoma by regulating miR-139-5p | PDF (2.2 MB)
  • 14 Views
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Article
miR-218 overexpression suppresses tumorigenesis of papillary thyroid cancer via inactivation of PTEN/PI3K/AKT pathway by targeting Runx2
Mingkun Han, Liwei Chen & Yang Wang
Pages: 6305-6316
Published online: 14 Nov 2022
AbstractformiR-218 overexpression suppresses tumorigenesis of papillary thyroid cancer via inactivation of PTEN/PI3K/AKT pathway by targeting Runx2 | Full Text | References | PDF (3.2 MB)
  • 108 Views
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Article
A ten-long non-coding RNA signature for predicting prognosis of patients with cervical cancer
Liang Shen, Haochen Yu, Ming Liu, Deying Wei, Wei Liu, Changzhong Li & Qin Chang
Pages: 6317-6326
Published online: 14 Nov 2022
AbstractforA ten-long non-coding RNA signature for predicting prognosis of patients with cervical cancer | Full Text | References | PDF (2.7 MB)
  • 68 Views
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Case Report

Case Report
Extramedullary relapse of acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation treated by CAR T-cell therapy: a case report
Dongmei Wang, Rui Shi, Qinglong Wang & Jianqiang Li
Pages: 6327-6332
Published online: 28 Sep 2018
AbstractforExtramedullary relapse of acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation treated by CAR T-cell therapy: a case report | Full Text | References | PDF (1.4 MB)
  • 128 Views
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Original Research

Article
Efficacy and safety of weekly nab-paclitaxel plus cisplatin with concurrent intensity-modulated radiotherapy in patients with inoperable, locally advanced esophageal cancer: a pilot trial
Daquan Wang, Wencheng Zhang, Dong Qian, Yong Guan, Xi Chen, Hualei Zhang, Jun Wang & Qingsong Pang
Pages: 6333-6338
Published online: 28 Sep 2018
AbstractforEfficacy and safety of weekly nab-paclitaxel plus cisplatin with concurrent intensity-modulated radiotherapy in patients with inoperable, locally advanced esophageal cancer: a pilot trial | Full Text | References | PDF (449 KB)
  • 87 Views
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Article
MicroRNA-1225-5p behaves as a tumor suppressor in human glioblastoma via targeting of IRS1
Dongyuan Li, Guonan Chi, Zhuo Chen & Xingyi Jin
Pages: 6339-6350
Published online: 28 Sep 2018
AbstractforMicroRNA-1225-5p behaves as a tumor suppressor in human glioblastoma via targeting of IRS1 | Full Text | References | PDF (5.2 MB)
  • 56 Views
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Article
Knockdown of CLDN6 inhibits cell proliferation and migration via PI3K/AKT/mTOR signaling pathway in endometrial carcinoma cell line HEC-1-B
Xia Cao & Guo-Zhao He
Pages: 6351-6360
Published online: 01 Oct 2018
AbstractforKnockdown of CLDN6 inhibits cell proliferation and migration via PI3K/AKT/mTOR signaling pathway in endometrial carcinoma cell line HEC-1-B | Full Text | References | PDF (3.5 MB)
  • 101 Views
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Review

Review Article
Siva-1 emerges as a tissue-specific oncogene beyond its classic role of a proapoptotic gene
Jiri Vachtenheim Jr, Robert Lischke & Jiri Vachtenheim
Pages: 6361-6367
Published online: 01 Oct 2018
AbstractforSiva-1 emerges as a tissue-specific oncogene beyond its classic role of a proapoptotic gene | Full Text | References | PDF (321.6 KB)
  • 68 Views
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Original Research

Article
NOP7 interacts with β-catenin and activates β-catenin/TCF signaling in hepatocellular carcinoma cells
Nan Wu, Jing Zhao, Youhua Yuan, Chuanjia Lu, Wenjing Zhu & Qun Jiang
Pages: 6369-6376
Published online: 01 Oct 2018
AbstractforNOP7 interacts with β-catenin and activates β-catenin/TCF signaling in hepatocellular carcinoma cells | Full Text | References | PDF (9 MB)
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Case Report

Case Report
Elemene treatment for NSCLC with multiple CNS metastases: a case report and literature review
Yushan Han, Xia Zhang, Yishan Lu, Yan Dong, Hong Fu, Bin Zhang & Yajie Gao
Pages: 6377-6382
Published online: 02 Oct 2018
AbstractforElemene treatment for NSCLC with multiple CNS metastases: a case report and literature review | Full Text | References | PDF (1.3 MB)
  • 41 Views
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Original Research

Article
LINC00460 modulates KDM2A to promote cell proliferation and migration by targeting miR-342-3p in gastric cancer
Fang Wang, Shaobo Liang, Xiaowei Liu, Lei Han, Junye Wang & Qin Du
Pages: 6383-6394
Published online: 02 Oct 2018
AbstractforLINC00460 modulates KDM2A to promote cell proliferation and migration by targeting miR-342-3p in gastric cancer | Full Text | References | PDF (3.9 MB)
  • 72 Views
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Article
H19 induced by oxidative stress confers temozolomide resistance in human glioma cells via activating NF-κB signaling
Shibo Duan, Ming Li, Zhifeng Wang, Longlong Wang & Yongjie Liu
Pages: 6395-6404
Published online: 02 Oct 2018
AbstractforH19 induced by oxidative stress confers temozolomide resistance in human glioma cells via activating NF-κB signaling | Full Text | References | PDF (1.4 MB)
  • 139 Views
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Article
Adverse events risk associated with regorafenib in the treatment of advanced solid tumors: meta-analysis of randomized controlled trials
Xiaonan Yin, Yuan Yin, Chaoyong Shen, Huijiao Chen, Jiang Wang, Zhaolun Cai, Zhixin Chen & Bo Zhang
Pages: 6405-6414
Published online: 02 Oct 2018
AbstractforAdverse events risk associated with regorafenib in the treatment of advanced solid tumors: meta-analysis of randomized controlled trials | Full Text | References | PDF (385.3 KB)
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Review

Review Article
LncRNA as a diagnostic and prognostic biomarker in bladder cancer: a systematic review and meta-analysis
Jing Quan, Xiang Pan, Liwen Zhao, Zuwei Li, Kangfu Dai, Fangli Yan, Suyue Liu, Hongfei Ma & Yongqing Lai
Pages: 6415-6424
Published online: 04 Oct 2018
AbstractforLncRNA as a diagnostic and prognostic biomarker in bladder cancer: a systematic review and meta-analysis | Full Text | References | PDF (809.7 KB)
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Original Research

Article
Co-expression network analysis identified CDH11 in association with progression and prognosis in gastric cancer
Peng-Fei Chen, Fan Wang, Jia-Yan Nie, Jue-Rong Feng, Jing Liu, Rui Zhou, Hong-Ling Wang & Qiu Zhao
Pages: 6425-6436
Published online: 02 Oct 2018
AbstractforCo-expression network analysis identified CDH11 in association with progression and prognosis in gastric cancer | Full Text | References | PDF (2.8 MB)
  • 115 Views
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Article
Radix Tetrastigma hemsleyani flavone exhibits antitumor activity in colorectal cancer via Wnt/β-catenin signaling pathway
Xiaowei Wu, Na Yu, Yuping Zhang, Yuanning Ye, Wenrong Sun, Lei Ye, Huimin Wu, Zhao Yang, Lin Wu & Fangyu Wang
Pages: 6437-6446
Published online: 04 Oct 2018
AbstractforRadix Tetrastigma hemsleyani flavone exhibits antitumor activity in colorectal cancer via Wnt/β-catenin signaling pathway | Full Text | References | PDF (2.6 MB)
  • 105 Views
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Article
TRIM28 is overexpressed in glioma and associated with tumor progression
Chunhai Su, Hui Li & Wenbo Gao
Pages: 6447-6458
Published online: 10 Oct 2018
AbstractforTRIM28 is overexpressed in glioma and associated with tumor progression | Full Text | References | PDF (3.2 MB)
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Review

Review Article
Evolving role of neurokinin 1-receptor antagonists for chemotherapy-induced nausea and vomiting
Rudolph M Navari & Lee S Schwartzberg
Pages: 6459-6478
Published online: 04 Oct 2018
AbstractforEvolving role of neurokinin 1-receptor antagonists for chemotherapy-induced nausea and vomiting | Full Text | References | PDF (592.8 KB)
  • 132 Views
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Review Article
The regulation of cytokine signaling by retinal determination gene network pathway in cancer
Xinhua Zheng, Qian Liu, Ming Yi, Shuang Qin & Kongming Wu
Pages: 6479-6487
Published online: 04 Oct 2018
AbstractforThe regulation of cytokine signaling by retinal determination gene network pathway in cancer | Full Text | References | PDF (1.2 MB)
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Original Research

Article
miR-431-5p alters the epithelial-to-mesenchymal transition markers by targeting UROC28 in hepatoma cells
Qinglei Kong, Jianhua Han, Hong Deng, Feilong Wu, Shaozhong Guo & Zhiqiang Ye
Pages: 6489-6503
Published online: 04 Oct 2018
AbstractformiR-431-5p alters the epithelial-to-mesenchymal transition markers by targeting UROC28 in hepatoma cells | Full Text | References | PDF (6.2 MB)
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Review

Review Article
Immune-checkpoint inhibitors for combating T-cell dysfunction in cancer
Ewelina Grywalska, Marcin Pasiarski, Stanisław Góźdź & Jacek Roliński
Pages: 6505-6524
Published online: 04 Oct 2018
AbstractforImmune-checkpoint inhibitors for combating T-cell dysfunction in cancer | Full Text | References | PDF (531.9 KB)
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Review Article
Pembrolizumab for the treatment of patients with recurrent locally advanced or metastatic gastric or gastroesophageal junction cancer: an evidence-based review of place in therapy
Rutika Mehta, Anand Shah & Khaldoun Almhanna
Pages: 6525-6537
Published online: 04 Oct 2018
AbstractforPembrolizumab for the treatment of patients with recurrent locally advanced or metastatic gastric or gastroesophageal junction cancer: an evidence-based review of place in therapy | Full Text | References | PDF (406 KB)
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Original Research

Article
The efficacy and safety of apatinib for refractory malignancies: a review and meta-analysis
Dantong Sun, Helei Hou, Chuantao Zhang & Xiaochun Zhang
Pages: 6539-6554
Published online: 05 Oct 2018
AbstractforThe efficacy and safety of apatinib for refractory malignancies: a review and meta-analysis | Full Text | References | PDF (3.2 MB)
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Article
Radiofrequency ablation of hepatocellular carcinoma: a meta-analysis of overall survival and recurrence-free survival
Andrea Casadei Gardini, Giorgia Marisi, Matteo Canale, Francesco Giuseppe Foschi, Gabriele Donati, Giorgio Ercolani, Martina Valgiusti, Alessandro Passardi, Giovanni Luca Frassineti & Emanuela Scarpi
Pages: 6555-6567
Published online: 05 Oct 2018
AbstractforRadiofrequency ablation of hepatocellular carcinoma: a meta-analysis of overall survival and recurrence-free survival | Full Text | References | PDF (876.6 KB)
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Article
Effects of insulin-like growth factor binding protein 3 on apoptosis of cutaneous squamous cell carcinoma cells
Jinli Liu, Yuanyuan Guo, Yuanyuna Huang, Haowei Xue, Suwen Bai, Jinhang Zhu, Xianming Xia, Bing Shen & Wei Fang
Pages: 6569-6577
Published online: 05 Oct 2018
AbstractforEffects of insulin-like growth factor binding protein 3 on apoptosis of cutaneous squamous cell carcinoma cells | Full Text | References | PDF (2 MB)
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Article
Knockdown of RNF6 inhibits gastric cancer cell growth by suppressing STAT3 signaling
Ziming Huang, Yong Cai, Chenchen Yang, Zhen Chen, Hong Sun, Yingying Xu, Wei Chen, Dafu Xu, Wenze Tian & Haixiao Wang
Pages: 6579-6587
Published online: 05 Oct 2018
AbstractforKnockdown of RNF6 inhibits gastric cancer cell growth by suppressing STAT3 signaling | Full Text | References | PDF (6.9 MB)
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Article
Nodal regulates bladder cancer cell migration and invasion via the ALK/Smad signaling pathway
Youkong Li, Wen Zhong, Min Zhu, Shengguo Hu & Xiaokang Su
Pages: 6589-6597
Published online: 05 Oct 2018
AbstractforNodal regulates bladder cancer cell migration and invasion via the ALK/Smad signaling pathway | Full Text | References | PDF (3 MB)
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Case Report

Case Report
Complete response associated with lenalidomide and celecoxib in a case of primary refractory Hodgkin lymphoma
Marta Garcia-Recio, Jordi Martinez-Serra, Francesc Mestre, Leyre Bento, Jordi Gines, Rafael Ramos, Jaime Daumal, Paloma López, Antonia Sampol & Antonio Gutierrez
Pages: 6599-6603
Published online: 08 Oct 2018
AbstractforComplete response associated with lenalidomide and celecoxib in a case of primary refractory Hodgkin lymphoma | Full Text | References | PDF (1.1 MB)
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Original Research

Article
Asparagine synthetase expression is associated with the sensitivity to asparaginase in extranodal natural killer/T-cell lymphoma in vivo and in vitro
Wen-jian Liu, Hua Wang, Xiong-wen Peng, Wei-da Wang, Na-wei Liu, Yang Wang & Yue Lu
Pages: 6605-6615
Published online: 08 Oct 2018
AbstractforAsparagine synthetase expression is associated with the sensitivity to asparaginase in extranodal natural killer/T-cell lymphoma in vivo and in vitro | Full Text | References | PDF (4.6 MB)
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Article
Efficacy and safety of iodine-125 brachytherapy combined with chemotherapy in the treatment of advanced NSCLC in the elderly
Chunrong Wu, Bo Li, Guiyin Sun, Chunfang Peng & Debing Xiang
Pages: 6617-6624
Published online: 08 Oct 2018
AbstractforEfficacy and safety of iodine-125 brachytherapy combined with chemotherapy in the treatment of advanced NSCLC in the elderly | Full Text | References | PDF (1.2 MB)
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Case Report

Case Report
Male accessory breast cancer on the abdominal wall: a case report and literature review
Guo-Bin Zhong, Xin-Qing Ye, Jian-Lun Liu, Shu-Zhe Xiao, Qing-Hua Huang & Wei Wei
Pages: 6625-6631
Published online: 08 Oct 2018
AbstractforMale accessory breast cancer on the abdominal wall: a case report and literature review | Full Text | References | PDF (3.9 MB)
  • 80 Views
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Article
Predictive role of skin rash in advanced pancreatic cancer patients treated with gemcitabine plus erlotinib: a systematic review and meta-analysis
Minyan Zeng, Qi Feng, Ming Lu, Jun Zhou, Zuyao Yang & Jinling Tang
Pages: 6633-6646
Published online: 14 Nov 2022
AbstractforPredictive role of skin rash in advanced pancreatic cancer patients treated with gemcitabine plus erlotinib: a systematic review and meta-analysis | Full Text | References | PDF (1.6 MB)
  • 69 Views
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Article
Pim1 promotes cell proliferation and regulates glycolysis via interaction with MYC in ovarian cancer
Yong Wu, Yu Deng, Jun Zhu, Yachen Duan, WeiWei Weng & Xiaohua Wu
Pages: 6647-6656
Published online: 09 Oct 2018
AbstractforPim1 promotes cell proliferation and regulates glycolysis via interaction with MYC in ovarian cancer | Full Text | References | PDF (2.8 MB)
  • 141 Views
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Article
YAP regulates ALDH1A1 expression and stem cell property of bladder cancer cells
Ai-Yue Zhao, Yi-Jun Dai, Jian-Feng Lian, Yan Huang, Jian-Guang Lin, Yang-Bin Dai & Tian-Wen Xu
Pages: 6657-6663
Published online: 10 Oct 2018
AbstractforYAP regulates ALDH1A1 expression and stem cell property of bladder cancer cells | Full Text | References | PDF (3.9 MB)
  • 95 Views
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Article
Construction of a recombinant eukaryotic expression vector containing DNM3 gene and its expression in colon cancer cells
Liang Jiang, Qi-Lian Liang, Wei-Ming Liang, Hui-Jie Zhang, Jie Huang, Gao-Le Yuan, Xiao-Xia Peng, Shao-Ang Cheng, Zhi-Gang Huang & Xiang-Ning Zhang
Pages: 6665-6671
Published online: 09 Oct 2018
AbstractforConstruction of a recombinant eukaryotic expression vector containing DNM3 gene and its expression in colon cancer cells | Full Text | References | PDF (3 MB)
  • 98 Views
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Article
Clinical significance and biological roles of cyclins in gastric cancer
Hai-Ping Zhang, Shu-Yu Li, Jian-Ping Wang & Jun Lin
Pages: 6673-6685
Published online: 09 Oct 2018
AbstractforClinical significance and biological roles of cyclins in gastric cancer | Full Text | References | PDF (3.1 MB)
  • 89 Views
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Article
Effects of thyrotropin suppression on lumbar bone mineral density in postmenopausal women with differentiated thyroid carcinoma
Pei Zhang, Hui Xi & Ruihong Yan
Pages: 6687-6692
Published online: 09 Oct 2018
AbstractforEffects of thyrotropin suppression on lumbar bone mineral density in postmenopausal women with differentiated thyroid carcinoma | Full Text | References | PDF (503.3 KB)
  • 74 Views
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Article
Knockdown of RAI14 suppresses the progression of gastric cancer
Cheng Chen, Aihemaiti Maimaiti, Xin Zhang, Hui Qu, Qilong Sun, Qingsi He & Wenbin Yu
Pages: 6693-6703
Published online: 09 Oct 2018
AbstractforKnockdown of RAI14 suppresses the progression of gastric cancer | Full Text | References | PDF (5.2 MB)
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Article
Effects of proton pump inhibitors on reversing multidrug resistance via downregulating V-ATPases/PI3K/Akt/mTOR/HIF-1α signaling pathway through TSC1/2 complex and Rheb in human gastric adenocarcinoma cells in vitro and in vivo
Min Chen, Jian Lu, Wei Wei, Ying Lv, Xiaoqi Zhang, Yuling Yao, Lei Wang, Tingsheng Ling & Xiaoping Zou
Pages: 6705-6722
Published online: 10 Oct 2018
AbstractforEffects of proton pump inhibitors on reversing multidrug resistance via downregulating V-ATPases/PI3K/Akt/mTOR/HIF-1α signaling pathway through TSC1/2 complex and Rheb in human gastric adenocarcinoma cells in vitro and in vivo | Full Text | References | PDF (7.3 MB)
  • 136 Views
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Article
Circ-DLG1 promotes the proliferation of esophageal squamous cell carcinoma
Jun Rong, Qian Wang, Yanzhou Zhang, Daolong Zhu, Handong Sun, Weiwei Tang, Rongping Wang, Weihong Shi & Xiu-feng Cao
Pages: 6723-6730
Published online: 09 Oct 2018
AbstractforCirc-DLG1 promotes the proliferation of esophageal squamous cell carcinoma | Full Text | References | PDF (2.3 MB)
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Article
Role of monocyte-to-lymphocyte ratio in predicting sorafenib response in patients with advanced hepatocellular carcinoma
Zhenfeng Zhu, Litao Xu, Liping Zhuang, Zhouyu Ning, Chenyue Zhang, Xia Yan, Junhua Lin, Yehua Shen, Peng Wang & Zhiqiang Meng
Pages: 6731-6740
Published online: 10 Oct 2018
AbstractforRole of monocyte-to-lymphocyte ratio in predicting sorafenib response in patients with advanced hepatocellular carcinoma | Full Text | References | PDF (1.3 MB)
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Article
MTBP promotes migration and invasion by regulation of ZEB2-mediated epithelial–mesenchymal transition in lung cancer cells
Bo Pan, Haibo Han, Lina Wu, Ying Xiong, Jianzhi Zhang, Bin Dong, Yue Yang & Jinfeng Chen
Pages: 6741-6756
Published online: 10 Oct 2018
AbstractforMTBP promotes migration and invasion by regulation of ZEB2-mediated epithelial–mesenchymal transition in lung cancer cells | Full Text | References | PDF (7 MB)
  • 80 Views
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Article
Overexpression of long noncoding RNA NORAD in colorectal cancer associates with tumor progression
Lili Wang, Lutao Du, Weili Duan, Suzhen Yan, Yujiao Xie & Chuanxin Wang
Pages: 6757-6766
Published online: 10 Oct 2018
AbstractforOverexpression of long noncoding RNA NORAD in colorectal cancer associates with tumor progression | Full Text | References | PDF (3.9 MB)
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Article
Clinical significance of serum total oxidant/antioxidant status in patients with operable and advanced gastric cancer
Xue-Fang Du, Li-Li Zhang, De-Zhong Zhang, Lu Yang, Ying-Ying Fan & Shu-Ping Dong
Pages: 6767-6775
Published online: 10 Oct 2018
AbstractforClinical significance of serum total oxidant/antioxidant status in patients with operable and advanced gastric cancer | Full Text | References | PDF (1.4 MB)
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Article
MicroRNA-647 promotes the therapeutic effectiveness of argon–helium cryoablation and inhibits cell proliferation through targeting TRAF2 via the NF-κB signaling pathway in non-small cell lung cancer
Yun-song Zhang, Tianzi Chen, Ying Jiu Cai, Jianlin Dong, Fang Bai, Xiaojun Gao, Li Tian, Naiying Duan & Dan Liu
Pages: 6777-6784
Published online: 10 Oct 2018
AbstractforMicroRNA-647 promotes the therapeutic effectiveness of argon–helium cryoablation and inhibits cell proliferation through targeting TRAF2 via the NF-κB signaling pathway in non-small cell lung cancer | Full Text | References | PDF (2.2 MB)
  • 64 Views
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Article
Metastatic malignancies and the effect on arterial stiffness and blood pressure levels: the possible role of chemotherapy
Eleni Res, Stella Maria Kyvelou, Charalambos Vlachopoulos, Kyriaki Manousou, Dimitris Tousoulis, Christodoulos Stefanadis & Dimitris Pektasides
Pages: 6785-6793
Published online: 11 Oct 2018
AbstractforMetastatic malignancies and the effect on arterial stiffness and blood pressure levels: the possible role of chemotherapy | Full Text | References | PDF (365.3 KB)
  • 96 Views
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Article
Upregulation of AKIP1 contributes to metastasis and progression and predicts poor prognosis of patients with colorectal cancer
Weifang Jiang, Weiji Yang, Li Yuan & Fanlong Liu
Pages: 6795-6801
Published online: 11 Oct 2018
AbstractforUpregulation of AKIP1 contributes to metastasis and progression and predicts poor prognosis of patients with colorectal cancer | Full Text | References | PDF (2.4 MB)
  • 49 Views
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Article
EGFR-TKI-based vs non-EGFR-TKI-based adjuvant therapy in resected non-small-cell lung cancer with EGFR mutations: a meta-analysis of randomized controlled trials
Jing-Xun Wu, Qi He, Feng Ye, Qing-Xia Zhou, Hao-Jun Chen, Long Sun & Hua Wu
Pages: 6803-6810
Published online: 14 Nov 2022
AbstractforEGFR-TKI-based vs non-EGFR-TKI-based adjuvant therapy in resected non-small-cell lung cancer with EGFR mutations: a meta-analysis of randomized controlled trials | Full Text | References | PDF (749.5 KB)
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Article
SATB1 siRNA-encapsulated immunoliposomes conjugated with CD44 antibodies target and eliminate gastric cancer-initiating cells
Feng Yang, Zhi Zheng, Luming Zheng, Jianmin Qin, Haijia Li, Xuchao Xue, Jie Gao & Guoen Fang
Pages: 6811-6825
Published online: 11 Oct 2018
AbstractforSATB1 siRNA-encapsulated immunoliposomes conjugated with CD44 antibodies target and eliminate gastric cancer-initiating cells | Full Text | References | PDF (3.4 MB)
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Article
Cytidine monophosphate N-acetylneuraminic acid synthetase enhances invasion of human triple-negative breast cancer cells
Elizabeth M O’Day, Greg E Idos, Collin Hill, Joan W Chen & Gerhard Wagner
Pages: 6827-6838
Published online: 11 Oct 2018
AbstractforCytidine monophosphate N-acetylneuraminic acid synthetase enhances invasion of human triple-negative breast cancer cells | Full Text | References | PDF (2.5 MB)
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Case Report

Case Report
Renal Ewing sarcoma/primitive neuroectodermal tumor in a pregnant woman who underwent robot-assisted laparoscopic nephrectomy: a case report and literature review
Chenkui Miao, Jie Yang, Jianxin Xue, Jundong Zhu, Wen Chen, Yuan Qin & Zengjun Wang
Pages: 6839-6843
Published online: 11 Oct 2018
AbstractforRenal Ewing sarcoma/primitive neuroectodermal tumor in a pregnant woman who underwent robot-assisted laparoscopic nephrectomy: a case report and literature review | Full Text | References | PDF (4.7 MB)
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Original Research

Article
RETRACTED: The lncRNA TUG1 promotes epithelial ovarian cancer cell proliferation and invasion via the WNT/β-catenin pathway
Shankun Liu, Ying Liu, Qiang Lu, Xiao Zhou, Li Chen & Weifeng Liang
Pages: 6845-6851
Published online: 12 Oct 2018
AbstractforRETRACTED: The lncRNA TUG1 promotes epithelial ovarian cancer cell proliferation and invasion via the WNT/β-catenin pathway | PDF (1.9 MB)
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Case Report

Case Report
Malignant mixed ovarian germ cell tumor composed of immature teratoma, yolk sac tumor and embryonal carcinoma harboring an EGFR mutation: a case report
Yao Wang, Jia-Xin Yang, Mei Yu, Dong-Yan Cao & Keng Shen
Pages: 6853-6862
Published online: 12 Oct 2018
AbstractforMalignant mixed ovarian germ cell tumor composed of immature teratoma, yolk sac tumor and embryonal carcinoma harboring an EGFR mutation: a case report | Full Text | References | PDF (8.7 MB)
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Article
Low-dose hypomethylating agent decitabine in combination with aclacinomycin and cytarabine achieves a better outcome than standard FLAG chemotherapy in refractory/relapsed acute myeloid leukemia patients with poor-risk cytogenetics and mutations
Limin Li, Xiaoqian Zhang, Hongjuan Yu, Mingwen Zhang, Mengyuan Xu, Jie Liu, Yueyue Fu, Hongbin Meng, Chengfang Lyu, Xiaoxia Li & Jin Zhou
Pages: 6863-6870
Published online: 12 Oct 2018
AbstractforLow-dose hypomethylating agent decitabine in combination with aclacinomycin and cytarabine achieves a better outcome than standard FLAG chemotherapy in refractory/relapsed acute myeloid leukemia patients with poor-risk cytogenetics and mutations | Full Text | References | PDF (433.7 KB)
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Article
Downregulation of miR-638 promotes progression of breast cancer and is associated with prognosis of breast cancer patients
Minghong Li, Jian Wang & Haibo Liu
Pages: 6871-6877
Published online: 12 Oct 2018
AbstractforDownregulation of miR-638 promotes progression of breast cancer and is associated with prognosis of breast cancer patients | Full Text | References | PDF (750.4 KB)
  • 59 Views
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Article
Carbonic anhydrase IX enhances tumor cell proliferation and tumor progression in osteosarcoma
Kazuma Okuno, Takao Matsubara, Tomoki Nakamura, Takahiro Iino, Takuya Kakimoto, Kunihiro Asanuma, Akihiko Matsumine & Akihiro Sudo
Pages: 6879-6886
Published online: 12 Oct 2018
AbstractforCarbonic anhydrase IX enhances tumor cell proliferation and tumor progression in osteosarcoma | Full Text | References | PDF (2.2 MB)
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Article
RETRACTED: Synergistic suppression effect on tumor growth of acute myeloid leukemia by combining cytarabine with an engineered oncolytic vaccinia virus
Jiamin Peng, Shibing Wang, Weimin Fan, Shuangshuang Li, Yi Wu, Xiaozhou Mou, Jianchao Wang & Xiangmin Tong
Pages: 6887-6900
Published online: 15 Oct 2018
AbstractforRETRACTED: Synergistic suppression effect on tumor growth of acute myeloid leukemia by combining cytarabine with an engineered oncolytic vaccinia virus | PDF (7.7 MB)
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Review

Review Article
Targeting VEGF pathway to normalize the vasculature: an emerging insight in cancer therapy
Jing-biao Wu, Ya-ling Tang & Xin-hua Liang
Pages: 6901-6909
Published online: 14 Nov 2022
AbstractforTargeting VEGF pathway to normalize the vasculature: an emerging insight in cancer therapy | Full Text | References | PDF (591.1 KB)
  • 210 Views
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Original Research

Article
NFATC2 is a novel therapeutic target for colorectal cancer stem cells
Tingyuan Lang, Xiaojuan Ding, Liangsheng Kong, Xiaoyan Zhou, Zhiqi Zhang, Huangxian Ju & Shijia Ding
Pages: 6911-6924
Published online: 15 Oct 2018
AbstractforNFATC2 is a novel therapeutic target for colorectal cancer stem cells | Full Text | References | PDF (1.8 MB)
  • 114 Views
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Article
SMAGP a novel biomarker of cervical cancer development and progression
Yongqin Jia, Haiyu Li, Geli Liu & Fangzhou Song
Pages: 6925-6935
Published online: 15 Oct 2018
AbstractforSMAGP a novel biomarker of cervical cancer development and progression | Full Text | References | PDF (4.1 MB)
  • 64 Views
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Article
Crizotinib presented with promising efficacy but for concomitant mutation in next-generation sequencing-identified ROS1-rearranged non-small-cell lung cancer
Liang Zeng, Yizhi Li, Lili Xiao, Yi Xiong, Li Liu, Wenjuan Jiang, Jianfu Heng, Jingjing Qu, Nong Yang & Yongchang Zhang
Pages: 6937-6945
Published online: 15 Oct 2018
AbstractforCrizotinib presented with promising efficacy but for concomitant mutation in next-generation sequencing-identified ROS1-rearranged non-small-cell lung cancer | Full Text | References | PDF (651.4 KB)
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Article
Identification of driver genes associated with chemotherapy resistance of Ewing’s sarcoma
Hongyi Liao, Xianbiao Xie, Yuanyuan Xu & Gang Huang
Pages: 6947-6956
Published online: 14 Nov 2022
AbstractforIdentification of driver genes associated with chemotherapy resistance of Ewing’s sarcoma | Full Text | References | PDF (2 MB)
  • 135 Views
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Article
Identification of critically carcinogenesis-related genes in basal cell carcinoma
Jie Dai, Kang Lin, Yan Huang, Yan Lu, Wen-Qi Chen, Xiao-Rong Zhang, Bang-Shun He, Yu-Qin Pan, Shu-Kui Wang & Wei-Xin Fan
Pages: 6957-6967
Published online: 15 Oct 2018
AbstractforIdentification of critically carcinogenesis-related genes in basal cell carcinoma | Full Text | References | PDF (1.3 MB)
  • 93 Views
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Article
Genome-scale analysis identifies SERPINE1 and SPARC as diagnostic and prognostic biomarkers in gastric cancer
Ping Liao, Wei Li, Ruizheng Liu, Jamie K Teer, Biaobo Xu, Wei Zhang, Xi Li, Howard L Mcleod & Yijing He
Pages: 6969-6980
Published online: 15 Oct 2018
AbstractforGenome-scale analysis identifies SERPINE1 and SPARC as diagnostic and prognostic biomarkers in gastric cancer | Full Text | References | PDF (4.1 MB)
  • 90 Views
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Article
Inhibition of miR-10a-5p suppresses cholangiocarcinoma cell growth through downregulation of Akt pathway
Lili Gao, Xiaoping Yang, Hao Zhang, Minghua Yu, Jianting Long & Tao Yang
Pages: 6981-6994
Published online: 15 Oct 2018
AbstractforInhibition of miR-10a-5p suppresses cholangiocarcinoma cell growth through downregulation of Akt pathway | Full Text | References | PDF (823.3 KB)
  • 76 Views
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Article
Decreased pretherapy serum apolipoprotein A-I is associated with extent of metastasis and poor prognosis of non-small-cell lung cancer
Hui Shi, Haidong Huang, Jin Pu, Dongchen Shi, Yunye Ning, Yuchao Dong, Yiping Han, Paul Zarogoulidis & Chong Bai
Pages: 6995-7003
Published online: 15 Oct 2018
AbstractforDecreased pretherapy serum apolipoprotein A-I is associated with extent of metastasis and poor prognosis of non-small-cell lung cancer | Full Text | References | PDF (927.2 KB)
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Review

Review Article
TIM-3, a promising target for cancer immunotherapy
Yayi He, Jie Cao, Chao Zhao, Xuefei Li, Caicun Zhou & Fred R Hirsch
Pages: 7005-7009
Published online: 14 Nov 2022
AbstractforTIM-3, a promising target for cancer immunotherapy | Full Text | References | PDF (240.6 KB)
  • 417 Views
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Review Article
Research progress of the clinicopathologic features of lung adenosquamous carcinoma
Jing Wang, Yanling Wang, Mengting Tong, Hongming Pan & Da Li
Pages: 7011-7017
Published online: 16 Oct 2018
AbstractforResearch progress of the clinicopathologic features of lung adenosquamous carcinoma | Full Text | References | PDF (258.3 KB)
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Original Research

Article
Zileuton suppresses cholangiocarcinoma cell proliferation and migration through inhibition of the Akt signaling pathway
Sasikamon Khophai, Malinee Thanee, Anchalee Techasen, Nisana Namwat, Poramate Klanrit, Attapol Titapun, Apiwat Jarearnrat, Prakasit Sa-Ngiamwibool & Watcharin Loilome
Pages: 7019-7029
Published online: 16 Oct 2018
AbstractforZileuton suppresses cholangiocarcinoma cell proliferation and migration through inhibition of the Akt signaling pathway | Full Text | References | PDF (2.3 MB)
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Article
Brevilin A promotes oxidative stress and induces mitochondrial apoptosis in U87 glioblastoma cells
Jie Wang, Miao Li, Xiaolin Cui, Dongyue Lv, Lingling Jin, Muhammad Khan & Tonghui Ma
Pages: 7031-7040
Published online: 16 Oct 2018
AbstractforBrevilin A promotes oxidative stress and induces mitochondrial apoptosis in U87 glioblastoma cells | Full Text | References | PDF (2 MB)
  • 134 Views
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Review

Review Article
Clinical use of FLT3 inhibitors in acute myeloid leukemia
Grerk Sutamtewagul & Carlos E Vigil
Pages: 7041-7052
Published online: 16 Oct 2018
AbstractforClinical use of FLT3 inhibitors in acute myeloid leukemia | Full Text | References | PDF (321.6 KB)
  • 130 Views
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Original Research

Article
The functional verification of EGFR-CAR T-cells targeted to hypopharyngeal squamous cell carcinoma
Yi-Han Dong, Yi-Ming Ding, Wei Guo, Jun-Wei Huang, Zheng Yang, Yang Zhang & Xiao-Hong Chen
Pages: 7053-7059
Published online: 16 Oct 2018
AbstractforThe functional verification of EGFR-CAR T-cells targeted to hypopharyngeal squamous cell carcinoma | Full Text | References | PDF (767.2 KB)
  • 127 Views
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Article
Platelet-to-lymphocyte ratio and lymphocyte-to-white blood cell ratio predict the efficacy of neoadjuvant chemotherapy and the prognosis of locally advanced gastric cancer patients treated with the oxaliplatin and capecitabine regimen
Cheng Tang, Xi Cheng, Shan Yu, Yan Wang, Jun Hou, Qian Li, Zhenbin Shen, Tianshu Liu & Yuehong Cui
Pages: 7061-7075
Published online: 17 Oct 2018
AbstractforPlatelet-to-lymphocyte ratio and lymphocyte-to-white blood cell ratio predict the efficacy of neoadjuvant chemotherapy and the prognosis of locally advanced gastric cancer patients treated with the oxaliplatin and capecitabine regimen | Full Text | References | PDF (3.9 MB)
  • 59 Views
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Article
A systematic review and meta-analysis on the effect of angiogenesis blockade for the treatment of gastric cancer
Zhi-Gang Bai & Zhong-Tao Zhang
Pages: 7077-7087
Published online: 17 Oct 2018
AbstractforA systematic review and meta-analysis on the effect of angiogenesis blockade for the treatment of gastric cancer | Full Text | References | PDF (767.4 KB)
  • 95 Views
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Review

Review Article
Novel EXO-T vaccine using polyclonal CD4+ T cells armed with HER2-specific exosomes for HER2-positive breast cancer
Rong Li, Rajni Chibbar & Jim Xiang
Pages: 7089-7093
Published online: 17 Oct 2018
AbstractforNovel EXO-T vaccine using polyclonal CD4+ T cells armed with HER2-specific exosomes for HER2-positive breast cancer | Full Text | References | PDF (505.3 KB)
  • 104 Views
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Review Article
Mechanisms of resistance to BRAF and MEK inhibitors and clinical update of US Food and Drug Administration-approved targeted therapy in advanced melanoma
Sunilkumar Kakadia, Naveen Yarlagadda, Ramez Awad, Madappa Kundranda, Jiaxin Niu, Boris Naraev, Lida Mina, Tomislav Dragovich, Mark Gimbel & Fade Mahmoud
Pages: 7095-7107
Published online: 17 Oct 2018
AbstractforMechanisms of resistance to BRAF and MEK inhibitors and clinical update of US Food and Drug Administration-approved targeted therapy in advanced melanoma | Full Text | References | PDF (1.7 MB)
  • 263 Views
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Review Article
MicroRNA-195: a review of its role in cancers
Wanpeng Yu, Xiao Liang, Xiangdong Li, Yuan Zhang, Zhenqing Sun, Ying Liu & Jianxun Wang
Pages: 7109-7123
Published online: 17 Oct 2018
AbstractforMicroRNA-195: a review of its role in cancers | Full Text | References | PDF (1.2 MB)
  • 179 Views
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Original Research

Article
Overexpression of APC11 predicts worse survival in lung adenocarcinoma
Jiayu Zhou, Shizhen Zhang, Guoxiang Fu, Zhengfu He, Yong Xu, Weiwen Ye & Zhoumiao Chen
Pages: 7125-7132
Published online: 17 Oct 2018
AbstractforOverexpression of APC11 predicts worse survival in lung adenocarcinoma | Full Text | References | PDF (1.6 MB)
  • 43 Views
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Article
Lentivirus-mediated overexpression of HSDL2 suppresses cell proliferation and induces apoptosis in cholangiocarcinoma
Deng-Yong Zhang, Zhong Liu, Zheng Lu, Wan-Liang Sun, Xiang Ma, Pei Zhang, Bin-Quan Wu & Pei-Yuan Cui
Pages: 7133-7142
Published online: 17 Oct 2018
AbstractforLentivirus-mediated overexpression of HSDL2 suppresses cell proliferation and induces apoptosis in cholangiocarcinoma | Full Text | References | PDF (1.9 MB)
  • 60 Views
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Article
Tumoral response and tumoral phenotypic changes in a rat model of diethylnitrosamine-induced hepatocellular carcinoma after salirasib and sorafenib administration
Olga Ciccarelli, Arthur Colson, Christine De Saeger, Raymond Reding, Christine Sempoux, Isabelle A Leclercq & Peter Stärkel
Pages: 7143-7153
Published online: 17 Oct 2018
AbstractforTumoral response and tumoral phenotypic changes in a rat model of diethylnitrosamine-induced hepatocellular carcinoma after salirasib and sorafenib administration | Full Text | References | PDF (2.6 MB)
  • 62 Views
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Article
Gene expression analyses identify a relationship between stanniocalcin 2 and the malignant behavior of colorectal cancer
Jian Wang, Sana Sahengbieke, Xiaoping Xu, Lei Zhang, Xiaoming Xu, Lifeng Sun, Qun Deng, Da Wang, Dong Chen, Yuan Pan, Zhaohui Liu & Shaojun Yu
Pages: 7155-7168
Published online: 18 Oct 2018
AbstractforGene expression analyses identify a relationship between stanniocalcin 2 and the malignant behavior of colorectal cancer | Full Text | References | PDF (7.1 MB)
  • 109 Views
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Article
Prognostic value of NEK2 overexpression in digestive system cancers: a meta-analysis and systematic review
Qian Ren, Bowen Li, Min Liu, Zenan Hu & Yuping Wang
Pages: 7169-7178
Published online: 18 Oct 2018
AbstractforPrognostic value of NEK2 overexpression in digestive system cancers: a meta-analysis and systematic review | Full Text | References | PDF (747 KB)
  • 69 Views
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Article
Dosimetric comparison of volumetric-modulated arc therapy and intensity-modulated radiation therapy in patients with cervical cancer: a meta-analysis
Wei Bai, Changgui Kou, Weiying Yu, Yuanyuan Li, Wanqing Hua, Lei Yu & Jianfeng Wang
Pages: 7179-7186
Published online: 18 Oct 2018
AbstractforDosimetric comparison of volumetric-modulated arc therapy and intensity-modulated radiation therapy in patients with cervical cancer: a meta-analysis | Full Text | References | PDF (1.1 MB)
  • 146 Views
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Article
Lentivirus-mediated siRNA knockdown of SPHK1 inhibits proliferation and tumorigenesis of neuroblastoma
Lin Su, Junyan Tian, Jinsong Sun, Nuan Han, Lin Feng, Baohua Yu & Yuepeng Wang
Pages: 7187-7196
Published online: 18 Oct 2018
AbstractforLentivirus-mediated siRNA knockdown of SPHK1 inhibits proliferation and tumorigenesis of neuroblastoma | Full Text | References | PDF (1.3 MB)
  • 68 Views
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Article
Knockdown of lncRNA UCA1 inhibits proliferation and invasion of papillary thyroid carcinoma through regulating miR-204/IGFBP5 axis
Hongyu Liu, Ruil Li, Lianyue Guan & Tao Jiang
Pages: 7197-7204
Published online: 18 Oct 2018
AbstractforKnockdown of lncRNA UCA1 inhibits proliferation and invasion of papillary thyroid carcinoma through regulating miR-204/IGFBP5 axis | Full Text | References | PDF (2.4 MB)
  • 52 Views
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Open Access
Article
The miR-503 cluster is coordinately under-expressed in endometrial endometrioid adenocarcinoma and targets many oncogenes, cell cycle genes, DNA repair genes and chemotherapy response genes
Eric J Devor, Elizabeth Cha, Akshaya Warrier, Marina D Miller, Jesus Gonzalez-Bosquet & Kimberly K Leslie
Pages: 7205-7211
Published online: 18 Oct 2018
AbstractforThe miR-503 cluster is coordinately under-expressed in endometrial endometrioid adenocarcinoma and targets many oncogenes, cell cycle genes, DNA repair genes and chemotherapy response genes | Full Text | References | PDF (719.1 KB)
  • 64 Views
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Article
RETRACTED ARTICLE: TNFα promotes glioblastoma A172 cell mitochondrial apoptosis via augmenting mitochondrial fission and repression of MAPK–ERK–YAP signaling pathways
Changyu Lu, Xiaolei Chen, Qun Wang, Xinghua Xu & Bainan Xu
Pages: 7213-7227
Published online: 18 Oct 2018
AbstractforRETRACTED ARTICLE: TNFα promotes glioblastoma A172 cell mitochondrial apoptosis via augmenting mitochondrial fission and repression of MAPK–ERK–YAP signaling pathways | PDF (7.4 MB)
  • 69 Views
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Article
The elevated glutaminolysis of bladder cancer and T cells in a simulated tumor microenvironment contributes to the up-regulation of PD-L1 expression by interferon-γ
Liping Wang, Xuecheng Yang, Dan Li, Zhijuan Liang, Yuanbin Chen, Guofeng Ma, Yonghua Wang, Yongxin Li, Ye Liang & Haitao Niu
Pages: 7229-7243
Published online: 18 Oct 2018
AbstractforThe elevated glutaminolysis of bladder cancer and T cells in a simulated tumor microenvironment contributes to the up-regulation of PD-L1 expression by interferon-γ | Full Text | References | PDF (8.2 MB)
  • 90 Views
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Article
Long non-coding RNA ZEB1-AS1 promotes cell invasion and epithelial to mesenchymal transition through inducing ZEB1 expression in cervical cancer
Rongjie Cheng, Nan Li, Shuyan Yang, Lei Liu & Shiyu Han
Pages: 7245-7253
Published online: 18 Oct 2018
AbstractforLong non-coding RNA ZEB1-AS1 promotes cell invasion and epithelial to mesenchymal transition through inducing ZEB1 expression in cervical cancer | Full Text | References | PDF (3.5 MB)
  • 77 Views
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Article
Thymosin α1 suppresses migration and invasion of PD-L1 high-expressing non-small-cell lung cancer cells via inhibition of STAT3–MMP2 signaling
Cong Bo, Qiang Wu, Hai Zhao, Xuebing Li & Qinghua Zhou
Pages: 7255-7270
Published online: 23 Oct 2018
AbstractforThymosin α1 suppresses migration and invasion of PD-L1 high-expressing non-small-cell lung cancer cells via inhibition of STAT3–MMP2 signaling | Full Text | References | PDF (2.8 MB)
  • 95 Views
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Article
Radiation therapy’s efficacy on tongue cancer: a population-based survival analysis
Yu Zhu, Chengmao Zhou & Qixiong He
Pages: 7271-7276
Published online: 23 Oct 2018
AbstractforRadiation therapy’s efficacy on tongue cancer: a population-based survival analysis | Full Text | References | PDF (436.1 KB)
  • 98 Views
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Article
Efficacy and safety analysis on dendritic cell-based vaccine-treated high-grade glioma patients: a systematic review and meta-analysis
Changling Li, Ting Liu, Bo Zhou, Yubin Zhou, Huiying Yu & Yun Sun
Pages: 7277-7293
Published online: 24 Oct 2018
AbstractforEfficacy and safety analysis on dendritic cell-based vaccine-treated high-grade glioma patients: a systematic review and meta-analysis | Full Text | References | PDF (1.5 MB)
  • 92 Views
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Case Report

Case Report
Evidence of response to pembrolizumab in a patient with Lynch syndrome-related metastatic colon cancer
Pamela Salman, Sergio Panay, René Fernández, Mauricio Mahave & Cristian Soza-Ried
Pages: 7295-7300
Published online: 23 Oct 2018
AbstractforEvidence of response to pembrolizumab in a patient with Lynch syndrome-related metastatic colon cancer | Full Text | References | PDF (1.6 MB)
  • 144 Views
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Review

Review Article
MCL-1 inhibition in cancer treatment
Weiguo Xiang, Chao-Yie Yang & Longchuan Bai
Pages: 7301-7314
Published online: 23 Oct 2018
AbstractforMCL-1 inhibition in cancer treatment | Full Text | References | PDF (1.2 MB)
  • 418 Views
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Original Research

Article
Radioembolization versus chemoembolization for unresectable hepatocellular carcinoma: a meta-analysis of randomized trials
Andrea Casadei Gardini, Emiliano Tamburini, Mercedes Iñarrairaegui, Giovanni Luca Frassineti & Bruno Sangro
Pages: 7315-7321
Published online: 25 Oct 2018
AbstractforRadioembolization versus chemoembolization for unresectable hepatocellular carcinoma: a meta-analysis of randomized trials | Full Text | References | PDF (846.9 KB)
  • 130 Views
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Article
Clinical characterization of ERBB2 exon 20 insertions and heterogeneity of outcomes responding to afatinib in Chinese lung cancer patients
Zhefeng Liu, Lin Wu, Jun Cao, Zhe Yang, Chengzhi Zhou, Liming Cao, Hao Wu, Haibo Shen, Meiling Jin, Yong Zhang, Xinru Mao, Jianxing Xiang, Ke Ma, Bing Li, Tengfei Zhang & Yi Hu
Pages: 7323-7331
Published online: 23 Oct 2018
AbstractforClinical characterization of ERBB2 exon 20 insertions and heterogeneity of outcomes responding to afatinib in Chinese lung cancer patients | Full Text | References | PDF (2.3 MB)
  • 164 Views
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Article
Down-regulation of CXCL11 inhibits colorectal cancer cell growth and epithelial-mesenchymal transition
Yu Jie Gao, De Lin Liu, Sheng Li, Gao Feng Yuan, Li Li, Hong Yan Zhu & Guan Yi Cao
Pages: 7333-7343
Published online: 23 Oct 2018
AbstractforDown-regulation of CXCL11 inhibits colorectal cancer cell growth and epithelial-mesenchymal transition | Full Text | References | PDF (2.7 MB)
  • 102 Views
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Case Report

Case Report
Iodine-125 seed implantation and allogenic natural killer cell immunotherapy for hepatocellular carcinoma after liver transplantation: a case report
Silun Xie, Zhengyi Wu, Liang Zhou, Yingqing Liang, Xiaohua Wang, Lizhi Niu, Kecheng Xu, Jibing Chen & Mingjie Zhang
Pages: 7345-7352
Published online: 25 Oct 2018
AbstractforIodine-125 seed implantation and allogenic natural killer cell immunotherapy for hepatocellular carcinoma after liver transplantation: a case report | Full Text | References | PDF (3.5 MB)
  • 76 Views
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Review

Review Article
Enzalutamide-resistant castration-resistant prostate cancer: challenges and solutions
Marcello Tucci, Clizia Zichi, Consuelo Buttigliero, Francesca Vignani, Giorgio V Scagliotti & Massimo Di Maio
Pages: 7353-7368
Published online: 24 Oct 2018
AbstractforEnzalutamide-resistant castration-resistant prostate cancer: challenges and solutions | Full Text | References | PDF (343 KB)
  • 336 Views
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Review Article
The efficacy and safety of immune checkpoint inhibitor combination therapy in lung cancer: a systematic review and meta-analysis
Min Peng, Xing Li, Gu Lei, Yi Ming Weng, Meng Xue Hu & Qi Bin Song
Pages: 7369-7383
Published online: 24 Oct 2018
AbstractforThe efficacy and safety of immune checkpoint inhibitor combination therapy in lung cancer: a systematic review and meta-analysis | Full Text | References | PDF (2 MB)
  • 126 Views
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Original Research

Article
Contribution of dysregulated circRNA_100876 to proliferation and metastasis of esophageal squamous cell carcinoma
Sai Cao, Guohao Chen, Liumei Yan, Libo Li & Xianying Huang
Pages: 7385-7394
Published online: 24 Oct 2018
AbstractforContribution of dysregulated circRNA_100876 to proliferation and metastasis of esophageal squamous cell carcinoma | Full Text | References | PDF (3.3 MB)
  • 64 Views
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Open Access
Article
Notch1 serves as a prognostic factor and regulates metastasis via regulating EGFR expression in hypopharyngeal squamous cell carcinoma
Jiajun Tian, Xianfang Liu, Xiuxiu Liu, Peihang Jing, Na Sa, Haibo Wang & Wei Xu
Pages: 7395-7405
Published online: 24 Oct 2018
AbstractforNotch1 serves as a prognostic factor and regulates metastasis via regulating EGFR expression in hypopharyngeal squamous cell carcinoma | Full Text | References | PDF (6 MB)
  • 55 Views
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Article
Comprehensive bioinformatics analysis identifies several potential diagnostic markers and potential roles of cyclin family members in lung adenocarcinoma
Li-Wei Gao & Guo-Liang Wang
Pages: 7407-7415
Published online: 24 Oct 2018
AbstractforComprehensive bioinformatics analysis identifies several potential diagnostic markers and potential roles of cyclin family members in lung adenocarcinoma | Full Text | References | PDF (15.6 MB)
  • 74 Views
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Review

Review Article
Research progress on GP73 in malignant tumors
Rong Liang, Ziyu Liu, Xuemin Piao, Mingtang Zuo, Jinyan Zhang, Zhihui Liu, Yongqiang Li & Yan Lin
Pages: 7417-7421
Published online: 24 Oct 2018
AbstractforResearch progress on GP73 in malignant tumors | Full Text | References | PDF (221.6 KB)
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Case Report

Case Report
Activated pulmonary tuberculosis in a patient with melanoma during PD-1 inhibition: a case report
Wan He, Xiangmei Zhang, Wenwen Li, Cheng Kong, Yuanyang Wang, Lianyu Zhu, Ruilian Xu, Guofang Deng & Peize Zhang
Pages: 7423-7427
Published online: 24 Oct 2018
AbstractforActivated pulmonary tuberculosis in a patient with melanoma during PD-1 inhibition: a case report | Full Text | References | PDF (1.5 MB)
  • 75 Views
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Original Research

Article
Regulation of cell proliferation and metastasis by microRNA-593-5p in human gastric cancer
Han Yu, Weiyuan Wei, Wenlong Cao, Zexu Zhan, Linhai Yan, Kun Wu, Dongyi Xie, Bin Cai, Yubo Xie & Qiang Xiao
Pages: 7429-7440
Published online: 14 Nov 2022
AbstractforRegulation of cell proliferation and metastasis by microRNA-593-5p in human gastric cancer | Full Text | References | PDF (5.7 MB)
  • 57 Views
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Article
Options of medical treatment and laryngeal function preservation in elderly patients with medial wall pyriform sinus cancer
Qin Wang, Yehai Liu, Kaile Wu, Yi Zhao, Chaobing Gao, Busheng Tong & Ming Zhang
Pages: 7441-7446
Published online: 01 Nov 2018
AbstractforOptions of medical treatment and laryngeal function preservation in elderly patients with medial wall pyriform sinus cancer | Full Text | References | PDF (760.7 KB)
  • 55 Views
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Article
ARHGAP30 suppressed lung cancer cell proliferation, migration, and invasion through inhibition of the Wnt/β-catenin signaling pathway
Xiaoliang Mao & Jichun Tong
Pages: 7447-7457
Published online: 24 Oct 2018
AbstractforARHGAP30 suppressed lung cancer cell proliferation, migration, and invasion through inhibition of the Wnt/β-catenin signaling pathway | Full Text | References | PDF (4 MB)
  • 77 Views
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Article
The expression level and prognostic value of HIPK3 among non-small-cell lung cancer patients in China
Yifei Liu, Li Qian, Juanjuan Yang, Hua Huang, Jia Feng, Xiaoli Li, Tingting Bian, Honggang Ke, Jian Liu & Jianguo Zhang
Pages: 7459-7469
Published online: 25 Oct 2018
AbstractforThe expression level and prognostic value of HIPK3 among non-small-cell lung cancer patients in China | Full Text | References | PDF (2.5 MB)
  • 73 Views
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Article
Knockdown of CCNO decreases the tumorigenicity of gastric cancer by inducing apoptosis
Lan Li, Yu Cao, Hourong Zhou, Yu Li, Bing He, Xia Zhou, Zhao Nie, Li Liang, Ying Liu & Limin Ye
Pages: 7471-7481
Published online: 14 Nov 2022
AbstractforKnockdown of CCNO decreases the tumorigenicity of gastric cancer by inducing apoptosis | Full Text | References | PDF (2.1 MB)
  • 60 Views
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Open Access
Article
RETRACTED ARTICLE: Long noncoding RNA UCA1 promotes the proliferation, invasion, and migration of nasopharyngeal carcinoma cells via modulation of miR-145
Jing Wu, Mingyu Du, Qian Zhang, Wenjun Zhang, Yanxin Fan, Li Yin, Qian Fei, Xuesong Jiang, Wei Chen, Huanfeng Zhu, Pengwei Yan, Xia He & Xiuhua Bian
Pages: 7483-7492
Published online: 25 Oct 2018
AbstractforRETRACTED ARTICLE: Long noncoding RNA UCA1 promotes the proliferation, invasion, and migration of nasopharyngeal carcinoma cells via modulation of miR-145 | PDF (3.8 MB)
  • 44 Views
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Article
FAM129B promoted tumor invasion and proliferation via facilitating the phosphorylation of FAK signaling and associated with adverse clinical outcome of non-small cell lung cancer patients
Xiaoming Zhou, Fangfei Yang, Qin Zhang, Yuan Miao, Xuejun Hu, Ailin Li, Gang Hou, Qiuyue Wang & Jian Kang
Pages: 7493-7501
Published online: 25 Oct 2018
AbstractforFAM129B promoted tumor invasion and proliferation via facilitating the phosphorylation of FAK signaling and associated with adverse clinical outcome of non-small cell lung cancer patients | Full Text | References | PDF (4.1 MB)
  • 76 Views
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Article
miR-23b-3p and miR-130a-5p affect cell growth, migration and invasion by targeting CB1R via the Wnt/β-catenin signaling pathway in gastric carcinoma
Xiangshu Xian, Li Tang, Chengrong Wu & Liuye Huang
Pages: 7503-7512
Published online: 25 Oct 2018
AbstractformiR-23b-3p and miR-130a-5p affect cell growth, migration and invasion by targeting CB1R via the Wnt/β-catenin signaling pathway in gastric carcinoma | Full Text | References | PDF (3.7 MB)
  • 66 Views
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Article
Re-biopsy status among Chinese non-small-cell lung cancer patients who progressed after icotinib therapy
Hanping Wang, Li Zhang, Xiaoyan Si, Xiaotong Zhang & Mengzhao Wang
Pages: 7513-7519
Published online: 26 Oct 2018
AbstractforRe-biopsy status among Chinese non-small-cell lung cancer patients who progressed after icotinib therapy | Full Text | References | PDF (540.4 KB)
  • 54 Views
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Article
The impact of immunosenescence on the efficacy of immune checkpoint inhibitors in melanoma patients: a meta-analysis
Ping Li, Xuefang Yang, Yumiao Feng, Lijuan Wu, Wei Ma, Gaozhong Ding, Yun Wei & Lan Sun
Pages: 7521-7527
Published online: 14 Nov 2022
AbstractforThe impact of immunosenescence on the efficacy of immune checkpoint inhibitors in melanoma patients: a meta-analysis | Full Text | References | PDF (536.6 KB)
  • 69 Views
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Review

Review Article
Clinical and molecular characteristics associated with the efficacy of PD-1/PD-L1 inhibitors for solid tumors: a meta-analysis
Yi Ming Weng, Min Peng, Meng Xue Hu, Yi Yao & Qi Bin Song
Pages: 7529-7542
Published online: 14 Nov 2022
AbstractforClinical and molecular characteristics associated with the efficacy of PD-1/PD-L1 inhibitors for solid tumors: a meta-analysis | Full Text | References | PDF (1.4 MB)
  • 79 Views
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Original Research

Article
BMP-2 inhibits lung metastasis of osteosarcoma: an early investigation using an orthotopic model
Qisheng Xiong, Xuesong Wang, Lizhen Wang, Yan Huang, Xiaodong Tian, Yubo Fan & Chia-Ying Lin
Pages: 7543-7553
Published online: 29 Oct 2018
AbstractforBMP-2 inhibits lung metastasis of osteosarcoma: an early investigation using an orthotopic model | Full Text | References | PDF (6.3 MB)
  • 78 Views
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Case Report

Case Report
Successful alternative treatment for relapsed adult acute lymphoblastic leukemia with dendritic cells-cytokine-induced killer cells combined with a rituximab-based regimen
XiaoFang Xiao, XingNong Ye, Cheng Xu & Jian Huang
Pages: 7555-7558
Published online: 29 Oct 2018
AbstractforSuccessful alternative treatment for relapsed adult acute lymphoblastic leukemia with dendritic cells-cytokine-induced killer cells combined with a rituximab-based regimen | Full Text | References | PDF (981.8 KB)
  • 72 Views
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Original Research

Article
Sirt3 enhances glioma cell viability by stabilizing Ku70–BAX interaction
Ke Luo, Wei Huang & Shuang Tang
Pages: 7559-7567
Published online: 29 Oct 2018
AbstractforSirt3 enhances glioma cell viability by stabilizing Ku70–BAX interaction | Full Text | References | PDF (2.1 MB)
  • 47 Views
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Open Access
Article
ADAMTS8 targets ERK to suppress cell proliferation, invasion, and metastasis of hepatocellular carcinoma
Xuetao Zhao, Congrong Yang, Jianhua Wu & Yuemin Nan
Pages: 7569-7578
Published online: 29 Oct 2018
AbstractforADAMTS8 targets ERK to suppress cell proliferation, invasion, and metastasis of hepatocellular carcinoma | Full Text | References | PDF (3.6 MB)
  • 55 Views
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Article
GATA3 is downregulated in osteosarcoma and facilitates EMT as well as migration through regulation of slug
Linjie Ma, Wentao Xue & Xianghai Ma
Pages: 7579-7589
Published online: 30 Oct 2018
AbstractforGATA3 is downregulated in osteosarcoma and facilitates EMT as well as migration through regulation of slug | Full Text | References | PDF (2.2 MB)
  • 72 Views
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Open Access
Article
RGS17 inhibits tumorigenesis and improves 5-fluorouracil sensitivity in nasopharyngeal carcinoma
Qianqian Yu, Niankai Zhang, Yan Jiang, Yichuan Huang, Yuan-Yuan Lian, Tingting Liu, Na Li & Ge Guan
Pages: 7591-7600
Published online: 14 Nov 2022
AbstractforRGS17 inhibits tumorigenesis and improves 5-fluorouracil sensitivity in nasopharyngeal carcinoma | Full Text | References | PDF (5 MB)
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Open Access

Expression of Concern

Expression of Concern
Knockdown of immature colon carcinoma transcript-I inhibits proliferation of glioblastoma multiforme cells through Gap 2/mitotic phase arrest [Expression of concern]
Page: 7601
Published online: 30 Oct 2018
CitationforKnockdown of immature colon carcinoma transcript-I inhibits proliferation of glioblastoma multiforme cells through Gap 2/mitotic phase arrest [Expression of concern] | Full Text | PDF (145.6 KB)
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Original Research

Article
Protein tyrosine phosphatase L1 inhibits high-grade serous ovarian carcinoma progression by targeting IκBα
Yacheng Wang, Miao Li, Ting Huang & Jun Li
Pages: 7603-7612
Published online: 14 Nov 2022
AbstractforProtein tyrosine phosphatase L1 inhibits high-grade serous ovarian carcinoma progression by targeting IκBα | Full Text | References | PDF (2.9 MB)
  • 51 Views
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Article
RETRACTED ARTICLE: SIRT6 overexpression induces apoptosis of nasopharyngeal carcinoma by inhibiting NF-κB signaling
Lei Ouyang, Liang Yi, Jingkun Li, Shijiang Yi, Shisheng Li, Peng Liu & Xinming Yang
Pages: 7613-7624
Published online: 01 Nov 2018
AbstractforRETRACTED ARTICLE: SIRT6 overexpression induces apoptosis of nasopharyngeal carcinoma by inhibiting NF-κB signaling | PDF (2.4 MB)
  • 57 Views
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Article
Significance of PYK2 level as a prognosis predictor in patients with colon adenocarcinoma after surgical resection
Shufang Liu, Lingling Chen & Yunfei Xu
Pages: 7625-7634
Published online: 31 Oct 2018
AbstractforSignificance of PYK2 level as a prognosis predictor in patients with colon adenocarcinoma after surgical resection | Full Text | References | PDF (3.6 MB)
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Article
Clinicopathological analysis of PD-L2 expression in colorectal cancer
Peng-Da Guo, Zhong-Wen Sun, Hui-Jun Lai, Jie Yang, Ping-Ping Wu, Yun-Di Guo & Jing Sun
Pages: 7635-7642
Published online: 01 Nov 2018
AbstractforClinicopathological analysis of PD-L2 expression in colorectal cancer | Full Text | References | PDF (3.2 MB)
  • 95 Views
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Article
Acyl-CoA dehydrogenase long chain expression is associated with esophageal squamous cell carcinoma progression and poor prognosis
Dong-Lin Yu, Hong-Wei Li, Yang Wang, Cun-Qi Li, Dong You, Lei Jiang, Yi-Peng Song & Xing-Hua Li
Pages: 7643-7653
Published online: 31 Oct 2018
AbstractforAcyl-CoA dehydrogenase long chain expression is associated with esophageal squamous cell carcinoma progression and poor prognosis | Full Text | References | PDF (3.8 MB)
  • 77 Views
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Review

Review Article
A systematic review and meta-analysis of gastrointestinal events associated with nonoperative therapies for neuroendocrine tumors
Quhui Wu, Bo Chen, Guofu Yan, Zhulin Yang, Li Xiong & Jun He
Pages: 7655-7668
Published online: 31 Oct 2018
AbstractforA systematic review and meta-analysis of gastrointestinal events associated with nonoperative therapies for neuroendocrine tumors | Full Text | References | PDF (1.2 MB)
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Original Research

Article
Cytotoxic effect of Drimia maritima bulb extract and induction of mitochondrial apoptotic signaling in human breast cancer cells, MCF-7 and MDA-MB-468
Maryam Hamzeloo-Moghadam, Mahmoud Aghaei, Mohammad Hossein Abdolmohammadi, Amir Khalaj & Faranak Fallahian
Pages: 7669-7677
Published online: 31 Oct 2018
AbstractforCytotoxic effect of Drimia maritima bulb extract and induction of mitochondrial apoptotic signaling in human breast cancer cells, MCF-7 and MDA-MB-468 | Full Text | References | PDF (1.3 MB)
  • 83 Views
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Article
16-Hydroxycleroda-3,13-dien-15,16-olide induces anoikis in human renal cell carcinoma cells: involvement of focal adhesion disassembly and signaling
Yu-Chi Chen, Bu-Miin Huang, Wei-Chang Lee & Yung-Chia Chen
Pages: 7679-7690
Published online: 31 Oct 2018
Abstractfor16-Hydroxycleroda-3,13-dien-15,16-olide induces anoikis in human renal cell carcinoma cells: involvement of focal adhesion disassembly and signaling | Full Text | References | PDF (7.5 MB)
  • 62 Views
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Article
A meta-analysis of nivolumab for the treatment of advanced non-small-cell lung cancer
Shuo Chen, Bin Hu & Hui Li
Pages: 7691-7697
Published online: 31 Oct 2018
AbstractforA meta-analysis of nivolumab for the treatment of advanced non-small-cell lung cancer | Full Text | References | PDF (690 KB)
  • 80 Views
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Article
Low expression level of ASK1-interacting protein-1 correlated with tumor angiogenesis and poor survival in patients with esophageal squamous cell cancer
Dongfeng Sun, Chengyu Chen, Wensi Hu, Chenxi Zhong, Limin Fan, Xiaoming Song & Zhibo Gai
Pages: 7699-7707
Published online: 01 Nov 2018
AbstractforLow expression level of ASK1-interacting protein-1 correlated with tumor angiogenesis and poor survival in patients with esophageal squamous cell cancer | Full Text | References | PDF (1.7 MB)
  • 50 Views
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Article
The clinical feasibility of flexible bronchoscopy interventional therapy in patients with central airway stenosis and respiratory failure caused by malignancy
Jiwang Wang, Yang Yang, Wangjian Zha & Xiuwei Zhang
Pages: 7709-7714
Published online: 01 Nov 2018
AbstractforThe clinical feasibility of flexible bronchoscopy interventional therapy in patients with central airway stenosis and respiratory failure caused by malignancy | Full Text | References | PDF (673.7 KB)
  • 58 Views
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Article
lncRNA PCAT6 promotes non-small cell lung cancer cell proliferation, migration and invasion through regulating miR-330-5p
Li Hua Cui, Hai Rong Xu, Wu Yang & Li Jiang Yu
Pages: 7715-7724
Published online: 01 Nov 2018
AbstractforlncRNA PCAT6 promotes non-small cell lung cancer cell proliferation, migration and invasion through regulating miR-330-5p | Full Text | References | PDF (4 MB)
  • 57 Views
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Article
Underexpression of INPPL1 is associated with aggressive clinicopathologic characteristics in papillary thyroid carcinoma
Yi-Li Zhou, Chen Zheng, Yi-Tong Chen & Xue-Min Chen
Pages: 7725-7731
Published online: 01 Nov 2018
AbstractforUnderexpression of INPPL1 is associated with aggressive clinicopathologic characteristics in papillary thyroid carcinoma | Full Text | References | PDF (632.7 KB)
  • 44 Views
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Article
MicroRNA-645 targets urokinase plasminogen activator and decreases the invasive growth of MDA-MB-231 triple-negative breast cancer cells
Du Meng, Ming Lei, Yaxuan Han, Dongli Zhao, Xiaozhi Zhang, Yunyi Yang & Rui Liu
Pages: 7733-7743
Published online: 02 Nov 2018
AbstractforMicroRNA-645 targets urokinase plasminogen activator and decreases the invasive growth of MDA-MB-231 triple-negative breast cancer cells | Full Text | References | PDF (3 MB)
  • 94 Views
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Article
Decreased expression of peroxiredoxin1 inhibits proliferation, invasion, and metastasis of ovarian cancer cell
Ming-Jun Zheng, Jing Wang, Hui-Min Wang, Ling-Ling Gao, Xiao Li, Wen-Chao Zhang, Rui Gou, Qian Guo, Xin Nie, Juan-Juan Liu & Bei Lin
Pages: 7745-7761
Published online: 02 Nov 2018
AbstractforDecreased expression of peroxiredoxin1 inhibits proliferation, invasion, and metastasis of ovarian cancer cell | Full Text | References | PDF (6.6 MB)
  • 64 Views
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Article
Potential targets of TMEM176A in the growth of glioblastoma cells
Zhiguo Liu, Haixia An, Peng Song, Dejing Wang, Shichun Li, Kai Chen & Qi Pang
Pages: 7763-7775
Published online: 02 Nov 2018
AbstractforPotential targets of TMEM176A in the growth of glioblastoma cells | Full Text | References | PDF (6.4 MB)
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Article
Resveratrol, an activator of SIRT1, induces protective autophagy in non-small-cell lung cancer via inhibiting Akt/mTOR and activating p38-MAPK
Jing Wang, Jiamei Li, Naiqing Cao, Zhen Li, Jingying Han & Li Li
Pages: 7777-7786
Published online: 02 Nov 2018
AbstractforResveratrol, an activator of SIRT1, induces protective autophagy in non-small-cell lung cancer via inhibiting Akt/mTOR and activating p38-MAPK | Full Text | References | PDF (6.4 MB)
  • 253 Views
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Case Report

Case Report
Huge borderline phyllodes breast tumor with repeated recurrences and progression toward more malignant phenotype: a case report and literature review
Yining Wang, Yonglin Zhang, Guanglei Chen, Fangming Liu, Chao Liu, Tiantian Xu & Zhenhai Ma
Pages: 7787-7793
Published online: 02 Nov 2018
AbstractforHuge borderline phyllodes breast tumor with repeated recurrences and progression toward more malignant phenotype: a case report and literature review | Full Text | References | PDF (3.9 MB)
  • 67 Views
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Original Research

Article
PTPRF as a novel tumor suppressor through deactivation of ERK1/2 signaling in gastric adenocarcinoma
Xiang’an Tian, Chengju Yang, Liguang Yang, Qinli Sun & Naiqing Liu
Pages: 7795-7803
Published online: 02 Nov 2018
AbstractforPTPRF as a novel tumor suppressor through deactivation of ERK1/2 signaling in gastric adenocarcinoma | Full Text | References | PDF (1.3 MB)
  • 89 Views
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Article
Rab18 overexpression promotes proliferation and chemoresistance through regulation of mitochondrial function in human gastric cancer
Binge Wu, Rui Qi, Xu Liu, Lehua Qian & Zhongjun Wu
Pages: 7805-7820
Published online: 05 Nov 2018
AbstractforRab18 overexpression promotes proliferation and chemoresistance through regulation of mitochondrial function in human gastric cancer | Full Text | References | PDF (9.8 MB)
  • 70 Views
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Case Report

Case Report
Intestinal metastasis from primary ROS1-positive lung adenocarcinoma cancer patients responding to crizotinib
Hua-fei Chen, Qu-xia Zhang, You-cai Zhu, Kai-qi Du, Xiao-feng Li, Li-xin Wu, Wen-xian Wang & Chun-wei Xu
Pages: 7821-7825
Published online: 05 Nov 2018
AbstractforIntestinal metastasis from primary ROS1-positive lung adenocarcinoma cancer patients responding to crizotinib | Full Text | References | PDF (1.6 MB)
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Original Research

Article
Long noncoding RNA HOXD-AS1 in various cancers: a meta-analysis and TCGA data review
Fuhong Zhang, Xiaowan Chen, Kehu Xi, Zhiqiang Qiu, Youhu Wang, Yan Gui, Yun Hou, Kangbing Chen & Xiaobing Zhang
Pages: 7827-7840
Published online: 05 Nov 2018
AbstractforLong noncoding RNA HOXD-AS1 in various cancers: a meta-analysis and TCGA data review | Full Text | References | PDF (4.4 MB)
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Article
TRIM32 overexpression improves chemoresistance through regulation of mitochondrial function in non-small-cell lung cancers
Yaming Du, Wei Zhang, Binghui Du, Sheng Zang, Xinpeng Wang, Xin Mao & Zhansheng Hu
Pages: 7841-7852
Published online: 05 Nov 2018
AbstractforTRIM32 overexpression improves chemoresistance through regulation of mitochondrial function in non-small-cell lung cancers | Full Text | References | PDF (3.3 MB)
  • 62 Views
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Article
RETRACTED ARTICLE: EZH2 contributes to 5-FU resistance in gastric cancer by epigenetically suppressing FBXO32 expression
Chenyu Wang, Xingwang Li, Junjie Zhang, Zheng Ge, Hejin Chen & Junhong Hu
Pages: 7853-7864
Published online: 05 Nov 2018
AbstractforRETRACTED ARTICLE: EZH2 contributes to 5-FU resistance in gastric cancer by epigenetically suppressing FBXO32 expression | PDF (2.3 MB)
  • 43 Views
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Article
Inhibition of GLUT-1 expression and the PI3K/Akt pathway to enhance the chemosensitivity of laryngeal carcinoma cells in vitro
Tao Jiang, Min-Li Zhou & Jun Fan
Pages: 7865-7872
Published online: 06 Nov 2018
AbstractforInhibition of GLUT-1 expression and the PI3K/Akt pathway to enhance the chemosensitivity of laryngeal carcinoma cells in vitro | Full Text | References | PDF (1.1 MB)
  • 112 Views
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Article
OCT4, SOX2, and NANOG positive expression correlates with poor differentiation, advanced disease stages, and worse overall survival in HER2+ breast cancer patients
Fan Yang, Jiaming Zhang & Hua Yang
Pages: 7873-7881
Published online: 06 Nov 2018
AbstractforOCT4, SOX2, and NANOG positive expression correlates with poor differentiation, advanced disease stages, and worse overall survival in HER2+ breast cancer patients | Full Text | References | PDF (1.5 MB)
  • 107 Views
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Article
Transcatheter hepatic arterial infusion chemotherapy vs sorafenib in the treatment of patients with hepatocellular carcinoma of Barcelona Clinic Liver Cancer stage C: a meta-analysis of Asian population
Jia-Yan Ni, Shan-Shan Liu, Hong-Liang Sun, Wei-Dong Wang, Ze-Long Zhong, Si-Nan Hou, Yao-Ting Chen & Lin-Feng Xu
Pages: 7883-7894
Published online: 14 Nov 2022
AbstractforTranscatheter hepatic arterial infusion chemotherapy vs sorafenib in the treatment of patients with hepatocellular carcinoma of Barcelona Clinic Liver Cancer stage C: a meta-analysis of Asian population | Full Text | References | PDF (1.5 MB)
  • 52 Views
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Article
Therapeutic strategies of melatonin in cancer patients: a systematic review and meta-analysis
Yi Wang, Pengcheng Wang, Xiaoli Zheng & Xing Du
Pages: 7895-7908
Published online: 14 Nov 2022
AbstractforTherapeutic strategies of melatonin in cancer patients: a systematic review and meta-analysis | Full Text | References | PDF (1 MB)
  • 210 Views
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Article
Clinical evaluation of vascular normalization induced by recombinant human endostatin in nasopharyngeal carcinoma via dynamic contrast-enhanced ultrasonography
Zhendong Yang, Min Kang, Shangyong Zhu, Jianyuan Huang, Xigui Li & Rensheng Wang
Pages: 7909-7917
Published online: 14 Nov 2022
AbstractforClinical evaluation of vascular normalization induced by recombinant human endostatin in nasopharyngeal carcinoma via dynamic contrast-enhanced ultrasonography | Full Text | References | PDF (1.3 MB)
  • 52 Views
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Article
MicroRNA-18a promotes hepatocellular carcinoma proliferation, migration, and invasion by targeting Bcl2L10
Xiaodong Wang, Jian Lu, Jisen Cao, Bozhao Ma, Chao Gao & Feng Qi
Pages: 7919-7934
Published online: 09 Nov 2018
AbstractforMicroRNA-18a promotes hepatocellular carcinoma proliferation, migration, and invasion by targeting Bcl2L10 | Full Text | References | PDF (10.1 MB)
  • 66 Views
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Article
TRIM37 targets AKT in the growth of lung cancer cells
Shumin Dong, Xueqin Pang, Haijun Sun, Chunluan Yuan, Chuanyong Mu & Shiying Zheng
Pages: 7935-7945
Published online: 08 Nov 2018
AbstractforTRIM37 targets AKT in the growth of lung cancer cells | Full Text | References | PDF (9.9 MB)
  • 69 Views
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Article
Matched-pair analysis of survival in the patients with T3 laryngeal squamous cell carcinoma treated with supracricoid partial laryngectomy or total laryngectomy
Xin Xia, Ying-Ying Zhu, Wen-Wen Diao, Xiao-Li Zhu, Xiao-Hua Shi, Wu-Yi Li, Zhi-Qiang Gao, Guo-Jun Li & Xing-Ming Chen
Pages: 7947-7953
Published online: 09 Nov 2018
AbstractforMatched-pair analysis of survival in the patients with T3 laryngeal squamous cell carcinoma treated with supracricoid partial laryngectomy or total laryngectomy | Full Text | References | PDF (982.9 KB)
  • 46 Views
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Article
RETRACTED ARTICLE: lncRNA differentiation antagonizing nonprotein coding RNA overexpression accelerates progression and indicates poor prognosis in pancreatic ductal adenocarcinoma
Lei Chen, Jie Liu, Tong Tang, Yong-Chuan Zhang, Ming-Zhong Liu, Li-Ya Xu & Jun Zhang
Pages: 7955-7965
Published online: 09 Nov 2018
AbstractforRETRACTED ARTICLE: lncRNA differentiation antagonizing nonprotein coding RNA overexpression accelerates progression and indicates poor prognosis in pancreatic ductal adenocarcinoma | PDF (1.6 MB)
  • 30 Views
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Article
miR-185 suppresses progression of Ewing’s sarcoma via inhibiting the PI3K/AKT and Wnt/β-catenin pathways
Shuai Zhang, Dong Li, Guang-jun Jiao, Hong-liang Wang & Ting-bin Yan
Pages: 7967-7977
Published online: 09 Nov 2018
AbstractformiR-185 suppresses progression of Ewing’s sarcoma via inhibiting the PI3K/AKT and Wnt/β-catenin pathways | Full Text | References | PDF (3.2 MB)
  • 74 Views
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Article
The prognostic roles of mRNAs of the exosomes derived from bone marrow stromal cells in common malignancies: a bioinformatic study
Fei Zhao & Yan-Qiu Yu
Pages: 7979-7986
Published online: 12 Nov 2018
AbstractforThe prognostic roles of mRNAs of the exosomes derived from bone marrow stromal cells in common malignancies: a bioinformatic study | Full Text | References | PDF (1.8 MB)
  • 65 Views
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Article
RETRACTED ARTICLE: Lupeol inhibits growth and migration in two human colorectal cancer cell lines by suppression of Wnt–β-catenin pathway
Yihao Wang, Dan Hong, Yuqin Qian, Xuezi Tu, Keke Wang, Xianhong Yang, Sijia Shao, Xinlong Kong, Zhefeng Lou & Longjin Jin
Pages: 7987-7999
Published online: 09 Nov 2018
AbstractforRETRACTED ARTICLE: Lupeol inhibits growth and migration in two human colorectal cancer cell lines by suppression of Wnt–β-catenin pathway | PDF (4.3 MB)
  • 18 Views
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Article
Long noncoding RNA H19 mediated the chemosensitivity of breast cancer cells via Wnt pathway and EMT process
Hongli Gao, Guijun Hao, Yue Sun, Liye Li & Yukun Wang
Pages: 8001-8012
Published online: 09 Nov 2018
AbstractforLong noncoding RNA H19 mediated the chemosensitivity of breast cancer cells via Wnt pathway and EMT process | Full Text | References | PDF (3.6 MB)
  • 113 Views
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Erratum

Correction
SNHG8 is identified as a key regulator in non-small-cell lung cancer progression sponging to miR-542-3p by targeting CCND1/CDK6 [Erratum]
Page: 8013
Published online: 12 Nov 2018
CitationforSNHG8 is identified as a key regulator in non-small-cell lung cancer progression sponging to miR-542-3p by targeting CCND1/CDK6 [Erratum] | Full Text | PDF (154 KB)
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Original Research

Article
Patterns of regional nodal relapse after D2 lymphadenectomy in gastric cancer: rethinking the target volume
Wang Yang, Menglong Zhou, Ran Hu, Guichao Li, Yan Wang, Lijun Shen, Liping Liang, Jianing Yang & Zhen Zhang
Pages: 8015-8024
Published online: 14 Nov 2022
AbstractforPatterns of regional nodal relapse after D2 lymphadenectomy in gastric cancer: rethinking the target volume | Full Text | References | PDF (3.3 MB)
  • 48 Views
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Article
miR-517a promotes Warburg effect in HCC by directly targeting FBP1
Delin Zhang, Zhu Li, Tao Li, Dan Luo, Xinfu Feng, Yan Liu & Jianzhao Huang
Pages: 8025-8032
Published online: 13 Nov 2018
AbstractformiR-517a promotes Warburg effect in HCC by directly targeting FBP1 | Full Text | References | PDF (1.1 MB)
  • 62 Views
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Article
Knockdown of HOXA transcript at the distal tip suppresses the growth and invasion and induces apoptosis of oral tongue squamous carcinoma cells
Mingkui Mu, Yue Li, Yuanbo Zhan, Xin Li & Bin Zhang
Pages: 8033-8044
Published online: 13 Nov 2018
AbstractforKnockdown of HOXA transcript at the distal tip suppresses the growth and invasion and induces apoptosis of oral tongue squamous carcinoma cells | Full Text | References | PDF (4.1 MB)
  • 58 Views
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Review

Review Article
Potential clinical application of lncRNAs in non-small cell lung cancer
Tong Lu, Yuanyong Wang, Di Chen, Jia Liu & Wenjie Jiao
Pages: 8045-8052
Published online: 13 Nov 2018
AbstractforPotential clinical application of lncRNAs in non-small cell lung cancer | Full Text | References | PDF (239.2 KB)
  • 151 Views
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Review Article
Clinicopathological and prognostic significance of circulating tumor cells in patients with esophageal cancer: a meta-analysis
Jinxuan Hou, Kun Zou, Chaogang Yang, Xiaohua Leng & Yu Xu
Pages: 8053-8061
Published online: 14 Nov 2022
AbstractforClinicopathological and prognostic significance of circulating tumor cells in patients with esophageal cancer: a meta-analysis | Full Text | References | PDF (692.7 KB)
  • 75 Views
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Original Research

Article
Celecoxib suppresses cutaneous squamous-cell carcinoma cell migration via inhibition of SDF1-induced endocytosis of CXCR4
Ting Gong, Yan Yu, Bo Yang, Min Lin, Jin-Wen Huang, Bo Cheng & Chao Ji
Pages: 8063-8071
Published online: 12 Nov 2018
AbstractforCelecoxib suppresses cutaneous squamous-cell carcinoma cell migration via inhibition of SDF1-induced endocytosis of CXCR4 | Full Text | References | PDF (4.9 MB)
  • 57 Views
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Article
Expression of CLIC1 as a potential biomarker for oral squamous cell carcinoma: a preliminary study
Ying Xu, Jie Xu, Jiali Feng, Jie Li, Chao Jiang, Xian Li, Sihai Zou, Qian Wang & Yong Li
Pages: 8073-8081
Published online: 14 Nov 2022
AbstractforExpression of CLIC1 as a potential biomarker for oral squamous cell carcinoma: a preliminary study | Full Text | References | PDF (2.1 MB)
  • 74 Views
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Article
Association of MLH1 single nucleotide polymorphisms with clinical outcomes of first-line irinotecan-based chemotherapy in colorectal cancer
Deqiang Wang, Xiaomei Zhang, Yan Zhang, Yuan Wu, Xin Guan, Wei Zhu, Mei Wang, Chuang Qi & Bo Shen
Pages: 8083-8088
Published online: 13 Nov 2018
AbstractforAssociation of MLH1 single nucleotide polymorphisms with clinical outcomes of first-line irinotecan-based chemotherapy in colorectal cancer | Full Text | References | PDF (503.7 KB)
  • 45 Views
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Article
High expression of TFEB is associated with aggressive clinical features in colorectal cancer
Jing Liang, Xinfeng Jia, Kun Wang & Niankun Zhao
Pages: 8089-8098
Published online: 13 Nov 2018
AbstractforHigh expression of TFEB is associated with aggressive clinical features in colorectal cancer | Full Text | References | PDF (2.6 MB)
  • 121 Views
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Review

Review Article
Lipocalin 2: a potential therapeutic target for breast cancer metastasis
Chenxia Hu, Ke Yang, Mengjie Li, Weiping Huang, Fengxue Zhang & Hongqi Wang
Pages: 8099-8106
Published online: 13 Nov 2018
AbstractforLipocalin 2: a potential therapeutic target for breast cancer metastasis | Full Text | References | PDF (3.4 MB)
  • 232 Views
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Original Research

Article
Follicle-stimulating hormone inhibits cervical cancer via NF-κB pathway
Xi Shi, Shiwei Qiu, Wei Zhuang, Caiji Wang, Shili Zhang, Na Yuan, Fukang Yuan & Yuehua Qiao
Pages: 8107-8115
Published online: 14 Nov 2018
AbstractforFollicle-stimulating hormone inhibits cervical cancer via NF-κB pathway | Full Text | References | PDF (1,019.6 KB)
  • 72 Views
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Article
In vitro and in vivo superior radiosensitizing effect of berbamine for head and neck squamous cell carcinoma
Hongmei Zhu, Shu Ruan, Feng Jia, Jiusheng Chu, Yong Zhu, Yongjiu Huang & Guan Liu
Pages: 8117-8125
Published online: 14 Nov 2018
AbstractforIn vitro and in vivo superior radiosensitizing effect of berbamine for head and neck squamous cell carcinoma | Full Text | References | PDF (1.5 MB)
  • 65 Views
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Article
Potential role of Toll-like receptor 2 expression and polymorphisms in colon cancer susceptibility in the Saudi Arabian population
Abdelhabib Semlali, Narasimha Reddy Parine, Nouf S Al-Numair, Mikhlid Almutairi, Yousef M Hawsawi, Abdullah Al Amri, Abdulrahman M Aljebreen, Maha Arafah, Majid A Almadi, Nahla Ali Azzam, Othman Alharbi & Mohammad Saud Alanazi
Pages: 8127-8141
Published online: 14 Nov 2018
AbstractforPotential role of Toll-like receptor 2 expression and polymorphisms in colon cancer susceptibility in the Saudi Arabian population | Full Text | References | PDF (1.5 MB)
  • 147 Views
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Article
Identification of tumor-educated platelet biomarkers of non-small-cell lung cancer
Meiling Sheng, Zhaohui Dong & Yanping Xie
Pages: 8143-8151
Published online: 14 Nov 2018
AbstractforIdentification of tumor-educated platelet biomarkers of non-small-cell lung cancer | Full Text | References | PDF (2.1 MB)
  • 182 Views
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Article
The anticancer activity of genistein is increased in estrogen receptor beta 1-positive breast cancer cells
Hua Jiang, Jingjing Fan, Lin Cheng, Pan Hu & Renbin Liu
Pages: 8153-8163
Published online: 14 Nov 2018
AbstractforThe anticancer activity of genistein is increased in estrogen receptor beta 1-positive breast cancer cells | Full Text | References | PDF (3 MB)
  • 137 Views
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Article
E2F transcription factor 8 promotes cell proliferation via CCND1/p21 in esophageal squamous cell carcinoma
Huiwen Chang, Jianxiang Song, Jixiang Wu & Yajun Zhang
Pages: 8165-8173
Published online: 15 Nov 2018
AbstractforE2F transcription factor 8 promotes cell proliferation via CCND1/p21 in esophageal squamous cell carcinoma | Full Text | References | PDF (2.5 MB)
  • 58 Views
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Article
MicroRNA-302a-3p suppresses hepatocellular carcinoma progression by inhibiting proliferation and invasion
Ying Ye, Yanan Song, Juhua Zhuang, Guoyu Wang, Jing Ni, Suiliang Zhang & Wei Xia
Pages: 8175-8184
Published online: 10 Dec 2018
AbstractforMicroRNA-302a-3p suppresses hepatocellular carcinoma progression by inhibiting proliferation and invasion | Full Text | References | PDF (2.6 MB)
  • 72 Views
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Article
RETRACTED: Polydatin exerts anti-tumor effects against renal cell carcinoma cells via induction of caspase-dependent apoptosis and inhibition of the PI3K/Akt pathway
Yi-Li Jin, Li-Min Xin, Chang-Chun Zhou & Yu Ren
Pages: 8185-8195
Published online: 16 Nov 2018
AbstractforRETRACTED: Polydatin exerts anti-tumor effects against renal cell carcinoma cells via induction of caspase-dependent apoptosis and inhibition of the PI3K/Akt pathway | PDF (4.4 MB)
  • 23 Views
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Case Report

Case Report
Primary clear cell adenocarcinoma of the pancreas: a case report and literature update
Pi-Jiang Sun, Yan-Hua Yu & Xi-Jun Cui
Pages: 8197-8200
Published online: 16 Nov 2018
AbstractforPrimary clear cell adenocarcinoma of the pancreas: a case report and literature update | Full Text | References | PDF (5.6 MB)
  • 69 Views
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Original Research

Article
Afatinib reverses ceritinib resistance (CR) in ALK/ROS1-positive non-small-cell lung cancer cell (NSCLC) via suppression of NRG1 pathway
Hui Chen, Qiang Zhang, Yu Zhang, Bin Jia, Bin Zhang & Changli Wang
Pages: 8201-8209
Published online: 26 Nov 2018
AbstractforAfatinib reverses ceritinib resistance (CR) in ALK/ROS1-positive non-small-cell lung cancer cell (NSCLC) via suppression of NRG1 pathway | Full Text | References | PDF (1.5 MB)
  • 62 Views
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Article
Alcoholic liver disease and risk of cholangiocarcinoma: a systematic review and meta-analysis
Jianping Xiong, ZiJun Yin, Weiyu Xu, Zheng Shen, Ye Li & Xin Lu
Pages: 8211-8219
Published online: 20 Nov 2018
AbstractforAlcoholic liver disease and risk of cholangiocarcinoma: a systematic review and meta-analysis | Full Text | References | PDF (714.2 KB)
  • 73 Views
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Article
Cytoskeleton-associated protein 4 is a novel serodiagnostic marker for esophageal squamous-cell carcinoma
Lei Chen, Chuanwen You, Xiaowei Jin, Lei Zhou, Liyou Huang & Yanhua Wang
Pages: 8221-8226
Published online: 20 Nov 2018
AbstractforCytoskeleton-associated protein 4 is a novel serodiagnostic marker for esophageal squamous-cell carcinoma | Full Text | References | PDF (704.1 KB)
  • 51 Views
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Article
Icotinib inhibits the proliferation of hepatocellular carcinoma cells in vitro and in vivo dependently on EGFR activation and PDL1 expression
Jisan Sun, Wentao Jiang, Dazhi Tian, Qingjun Guo & Zhongyang Shen
Pages: 8227-8237
Published online: 21 Nov 2018
AbstractforIcotinib inhibits the proliferation of hepatocellular carcinoma cells in vitro and in vivo dependently on EGFR activation and PDL1 expression | Full Text | References | PDF (2.6 MB)
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Review

Review Article
Clinical efficacy of immune checkpoint inhibitors in the treatment of unresectable advanced or recurrent gastric cancer: an evidence-based review of therapies
Kazuhiro Togasaki, Yasutaka Sukawa, Takanori Kanai & Hiromasa Takaishi
Pages: 8239-8250
Published online: 14 Nov 2022
AbstractforClinical efficacy of immune checkpoint inhibitors in the treatment of unresectable advanced or recurrent gastric cancer: an evidence-based review of therapies | Full Text | References | PDF (3.4 MB)
  • 139 Views
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Original Research

Article
Platelets enhance the ability of bone-marrow mesenchymal stem cells to promote cancer metastasis
Qianqian Wang, Zhuqian Li, Li Sun, Bin Chen, Yuanyuan Zhao, Bo Shen, Miaolin Zhu, Xiangdong Zhao, Changgen Xu, Mei Wang, Wenrong Xu & Wei Zhu
Pages: 8251-8263
Published online: 21 Nov 2018
AbstractforPlatelets enhance the ability of bone-marrow mesenchymal stem cells to promote cancer metastasis | Full Text | References | PDF (13.8 MB)
  • 71 Views
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Review

Review Article
The return of gemtuzumab ozogamicin: a humanized anti-CD33 monoclonal antibody–drug conjugate for the treatment of newly diagnosed acute myeloid leukemia
Pamela C Egan & John L Reagan
Pages: 8265-8272
Published online: 22 Nov 2018
AbstractforThe return of gemtuzumab ozogamicin: a humanized anti-CD33 monoclonal antibody–drug conjugate for the treatment of newly diagnosed acute myeloid leukemia | Full Text | References | PDF (366.7 KB)
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Corrigendum

Correction
Natural borneol is a novel chemosensitizer that enhances temozolomide-induced anticancer efficiency against human glioma by triggering mitochondrial dysfunction and reactive oxide species-mediated oxidative damage [Corrigendum]
Pages: 8273-8274
Published online: 22 Nov 2018
CitationforNatural borneol is a novel chemosensitizer that enhances temozolomide-induced anticancer efficiency against human glioma by triggering mitochondrial dysfunction and reactive oxide species-mediated oxidative damage [Corrigendum] | Full Text | PDF (1.9 MB)
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Original Research

Article
The effect of piperlongumine on endothelial and lung adenocarcinoma cells with regulated expression of profilin-1
Maciej Gagat, Marta Hałas-Wiśniewska, Wioletta Zielińska, Magdalena Izdebska, Dariusz Grzanka & Alina Grzanka
Pages: 8275-8292
Published online: 22 Nov 2018
AbstractforThe effect of piperlongumine on endothelial and lung adenocarcinoma cells with regulated expression of profilin-1 | Full Text | References | PDF (9.4 MB)
  • 64 Views
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Rapid Communication

Article
Quaternized chitosan promotes the antiproliferative effect of vemurafenib in melanoma cells by increasing cell permeability
Min Li & Ying Yang
Pages: 8293-8299
Published online: 22 Nov 2018
AbstractforQuaternized chitosan promotes the antiproliferative effect of vemurafenib in melanoma cells by increasing cell permeability | Full Text | References | PDF (3.1 MB)
  • 61 Views
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Original Research

Article
Modified FOLFOX6 as a first-line treatment for patients with advanced gastric cancer with massive ascites or inadequate oral intake
Hiroki Osumi, Daisuke Takahari, Keisho Chin, Mariko Ogura, Takashi Ichimura, Takeru Wakatsuki, Takeshi Suzuki, Yumiko Ota, Izuma Nakayama, Akira Ooki, Mitsukuni Suenaga, Eiji Shinozaki & Kensei Yamaguchi
Pages: 8301-8307
Published online: 23 Nov 2018
AbstractforModified FOLFOX6 as a first-line treatment for patients with advanced gastric cancer with massive ascites or inadequate oral intake | Full Text | References | PDF (335.2 KB)
  • 85 Views
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Open Access
Article
Associations between the NUDT15 R139C polymorphism and susceptibility to thiopurine-induced leukopenia in Asians: a meta-analysis
Yulan Liu, Yang Meng, Lu Wang, Zhou Liu, Jiao Li & Weiguo Dong
Pages: 8309-8317
Published online: 14 Nov 2022
AbstractforAssociations between the NUDT15 R139C polymorphism and susceptibility to thiopurine-induced leukopenia in Asians: a meta-analysis | Full Text | References | PDF (731.6 KB)
  • 96 Views
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Article
Prognostic significance of mammary Paget’s disease in Chinese women: a 10-year, population-based, matched cohort study
Huanhuan Zhou, Kongbeng Lu, Lei Zheng, Liwei Guo, Yun Gao, Xianyuan Miao, Zhanhong Chen & Xiaojia Wang
Pages: 8319-8326
Published online: 23 Nov 2018
AbstractforPrognostic significance of mammary Paget’s disease in Chinese women: a 10-year, population-based, matched cohort study | Full Text | References | PDF (1.1 MB)
  • 55 Views
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Review

Review Article
New developments in the treatment of basal cell carcinoma: update on current and emerging treatment options with a focus on vismodegib
Peter Koelblinger & Roland Lang
Pages: 8327-8340
Published online: 23 Nov 2018
AbstractforNew developments in the treatment of basal cell carcinoma: update on current and emerging treatment options with a focus on vismodegib | Full Text | References | PDF (304.7 KB)
  • 127 Views
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Original Research

Article
KIAA1199 overexpression is associated with abnormal expression of EMT markers and is a novel independent prognostic biomarker for hepatocellular carcinoma
Zhengchen Jiang, Xiangyu Zhai, Binyao Shi, Dan Luo & Bin Jin
Pages: 8341-8348
Published online: 23 Nov 2018
AbstractforKIAA1199 overexpression is associated with abnormal expression of EMT markers and is a novel independent prognostic biomarker for hepatocellular carcinoma | Full Text | References | PDF (5.5 MB)
  • 47 Views
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Article
TGF-beta 1 levels are associated with lymphocyte percentages in patients with lung cancer treated with radiation therapy
Jing Luo, Sainan Hu, Tingting Wei, Jifeng Sun, Ningbo Liu & Jun Wang
Pages: 8349-8355
Published online: 26 Nov 2018
AbstractforTGF-beta 1 levels are associated with lymphocyte percentages in patients with lung cancer treated with radiation therapy | Full Text | References | PDF (327.2 KB)
  • 69 Views
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Corrigendum

Correction
MTBP promotes migration and invasion by regulation of ZEB2-mediated epithelial–mesenchymal transition in lung cancer cells [Corrigendum]
Page: 8357
Published online: 26 Nov 2018
CitationforMTBP promotes migration and invasion by regulation of ZEB2-mediated epithelial–mesenchymal transition in lung cancer cells [Corrigendum] | Full Text | PDF (143 KB)
  • 53 Views
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Original Research

Article
Is APC hypermethylation a diagnostic biomarker for bladder cancer? A meta-analysis
Wei Han, Yutao Wang, Jingli Fan & Chunlei Wang
Pages: 8359-8369
Published online: 27 Nov 2018
AbstractforIs APC hypermethylation a diagnostic biomarker for bladder cancer? A meta-analysis | Full Text | References | PDF (2.9 MB)
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Article
GDF11 restrains tumor growth by promoting apoptosis in pancreatic cancer
Yanzhe Liu, Lijuan Shao, Kuang Chen, Zizheng Wang, Jin Wang, Wei Jing & Minggen Hu
Pages: 8371-8379
Published online: 27 Nov 2018
AbstractforGDF11 restrains tumor growth by promoting apoptosis in pancreatic cancer | Full Text | References | PDF (3.6 MB)
  • 122 Views
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Article
Prognostic roles of mRNA expression of peroxiredoxins in lung cancer
Liangyuan Chen, Chunli Huang, Xiaojun Yang, Qiuqin Zhang & Falin Chen
Pages: 8381-8388
Published online: 27 Nov 2018
AbstractforPrognostic roles of mRNA expression of peroxiredoxins in lung cancer | Full Text | References | PDF (3.7 MB)
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Review

Review Article
A comparison of fulvestrant plus a targeted agent with fulvestrant alone in hormone receptor-positive advanced breast cancer that progressed on prior endocrine therapy: a meta-analysis
Liang Xu, Ningning Yan, Zhihua Li, Lihua Luo, Xiaobo Wu, Qiuming Liu, Yingchun Xu & Yali Cao
Pages: 8389-8398
Published online: 27 Nov 2018
AbstractforA comparison of fulvestrant plus a targeted agent with fulvestrant alone in hormone receptor-positive advanced breast cancer that progressed on prior endocrine therapy: a meta-analysis | Full Text | References | PDF (687.9 KB)
  • 46 Views
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Original Research

Article
LncRNA ANCR promotes proliferation and radiation resistance of nasopharyngeal carcinoma by inhibiting PTEN expression
Xingkai Ma, Jieyu Zhou, Jianyong Liu, Geping Wu, Yan Yu, Hongyan Zhu & Jisheng Liu
Pages: 8399-8408
Published online: 27 Nov 2018
AbstractforLncRNA ANCR promotes proliferation and radiation resistance of nasopharyngeal carcinoma by inhibiting PTEN expression | Full Text | References | PDF (1.7 MB)
  • 99 Views
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Open Access
Article
lncRNA FBXL19-AS1 regulates osteosarcoma cell proliferation, migration and invasion by sponging miR-346
Runsang Pan, Zhixu He, Wanyuan Ruan, Sun Li, Hui Chen, Zhiyu Chen, Fang Liu, Xiaobin Tian & Yingjie Nie
Pages: 8409-8420
Published online: 29 Nov 2018
AbstractforlncRNA FBXL19-AS1 regulates osteosarcoma cell proliferation, migration and invasion by sponging miR-346 | Full Text | References | PDF (3.4 MB)
  • 67 Views
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Article
Better efficacy of intrapleural infusion of bevacizumab with pemetrexed for malignant pleural effusion mediated from nonsquamous non-small cell lung cancer
Xinyu Song, Dawei Chen, Jun Guo, Li Kong, Haiyong Wang & Zhehai Wang
Pages: 8421-8426
Published online: 27 Nov 2018
AbstractforBetter efficacy of intrapleural infusion of bevacizumab with pemetrexed for malignant pleural effusion mediated from nonsquamous non-small cell lung cancer | Full Text | References | PDF (508.1 KB)
  • 45 Views
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Article
High expression of uPA related to p38MAPK in esophageal cancer indicates poor prognosis
Qilong Liu, Wenfeng Li, Shibin Yang & Zhaoguo Liu
Pages: 8427-8434
Published online: 14 Nov 2022
AbstractforHigh expression of uPA related to p38MAPK in esophageal cancer indicates poor prognosis | Full Text | References | PDF (932.9 KB)
  • 58 Views
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Article
XRCC1 rs1799782 (C194T) polymorphism correlated with tumor metastasis and molecular subtypes in breast cancer
Qing Li, Rong Ma & Mei Zhang
Pages: 8435-8444
Published online: 28 Nov 2018
AbstractforXRCC1 rs1799782 (C194T) polymorphism correlated with tumor metastasis and molecular subtypes in breast cancer | Full Text | References | PDF (4.8 MB)
  • 119 Views
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Rapid Communication

Article
MiR-21-5p promotes the progression of non-small-cell lung cancer by regulating the expression of SMAD7
Xiangpan Li & Xiaofei Wu
Pages: 8445-8454
Published online: 28 Nov 2018
AbstractforMiR-21-5p promotes the progression of non-small-cell lung cancer by regulating the expression of SMAD7 | Full Text | References | PDF (2.8 MB)
  • 130 Views
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Original Research

Article
Inhibition of EZH2 and EGFR produces a synergistic effect on cell apoptosis by increasing autophagy in gastric cancer cells
Youping Yang, Feng Zhu, Qingmei Wang, Yan Ding, Rongbiao Ying & Linghui Zeng
Pages: 8455-8463
Published online: 29 Nov 2018
AbstractforInhibition of EZH2 and EGFR produces a synergistic effect on cell apoptosis by increasing autophagy in gastric cancer cells | Full Text | References | PDF (1.2 MB)
  • 95 Views
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Open Access
Article
RETRACTED ARTICLE: Overexpression of Mst1 reduces gastric cancer cell viability by repressing the AMPK-Sirt3 pathway and activating mitochondrial fission
Shiwei Yao & Wei Yan
Pages: 8465-8479
Published online: 29 Nov 2018
AbstractforRETRACTED ARTICLE: Overexpression of Mst1 reduces gastric cancer cell viability by repressing the AMPK-Sirt3 pathway and activating mitochondrial fission | PDF (5.4 MB)
  • 82 Views
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Article
Upregulation of SOX18 in colorectal cancer cells promotes proliferation and correlates with colorectal cancer risk
Zuohua Miao, Xiao Deng, Ping Shuai & Jing Zeng
Pages: 8481-8490
Published online: 29 Nov 2018
AbstractforUpregulation of SOX18 in colorectal cancer cells promotes proliferation and correlates with colorectal cancer risk | Full Text | References | PDF (1.5 MB)
  • 83 Views
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Article
Elevated FAM3C promotes cell epithelial– mesenchymal transition and cell migration in gastric cancer
Mengyue Shi, Guihua Duan, Shuang Nie, Shanshan Shen & Xiaoping Zou
Pages: 8491-8505
Published online: 05 Dec 2018
AbstractforElevated FAM3C promotes cell epithelial– mesenchymal transition and cell migration in gastric cancer | Full Text | References | PDF (5.9 MB)
  • 79 Views
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Article
Prolyl hydroxylase domain 3 influences the radiotherapy efficacy of pancreatic cancer cells by targeting hypoxia-inducible factor-1α
Li-rui Tang, Jun-xin Wu, Shao-li Cai, Yun-xia Huang, Xue-qing Zhang, Wan-kai Fu, Qing-yang Zhuang & Jin-luan Li
Pages: 8507-8515
Published online: 29 Nov 2018
AbstractforProlyl hydroxylase domain 3 influences the radiotherapy efficacy of pancreatic cancer cells by targeting hypoxia-inducible factor-1α | Full Text | References | PDF (2 MB)
  • 50 Views
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Article
Near-infrared nanoparticles based on indocyanine green-conjugated albumin: a versatile platform for imaging-guided synergistic tumor chemo-phototherapy with temperature-responsive drug release
Yuxin Ma, Xiaohua Liu, Qianli Ma & Yizhi Liu
Pages: 8517-8528
Published online: 29 Nov 2018
AbstractforNear-infrared nanoparticles based on indocyanine green-conjugated albumin: a versatile platform for imaging-guided synergistic tumor chemo-phototherapy with temperature-responsive drug release | Full Text | References | PDF (3.4 MB)
  • 93 Views
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Article
A novel long-sustaining system of apatinib for long-term inhibition of the proliferation of hepatocellular carcinoma cells
Yanli Wang & Zigui Tang
Pages: 8529-8541
Published online: 29 Nov 2018
AbstractforA novel long-sustaining system of apatinib for long-term inhibition of the proliferation of hepatocellular carcinoma cells | Full Text | References | PDF (1.9 MB)
  • 86 Views
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Article
Vandetanib (ZD6474) induces antiangiogenesis through mTOR–HIF-1 alpha–VEGF signaling axis in breast cancer cells
Ling Li, Jingkui Yu, Shuhong Jiao, Wei Wang, Fen Zhang & Shiqing Sun
Pages: 8543-8553
Published online: 29 Nov 2018
AbstractforVandetanib (ZD6474) induces antiangiogenesis through mTOR–HIF-1 alpha–VEGF signaling axis in breast cancer cells | Full Text | References | PDF (6.6 MB)
  • 96 Views
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Clinical Trial Report

Article
Local analgesic effect of a bioadhesive barrier-forming oral liquid in cancer patients with oral mucositis caused by chemotherapy and/or radiotherapy: a randomized multicenter, single-use, positive-controlled, open-label study
Yuan Cheng, Shu Kui Qin, Yan Ping Chen, Li Hua Dong, Xiang Dong Sun, Shi Ying Yu & Shi Kai Wu
Pages: 8555-8564
Published online: 30 Nov 2018
AbstractforLocal analgesic effect of a bioadhesive barrier-forming oral liquid in cancer patients with oral mucositis caused by chemotherapy and/or radiotherapy: a randomized multicenter, single-use, positive-controlled, open-label study | Full Text | References | PDF (445.7 KB)
  • 470 Views
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Original Research

Article
Afatinib vs erlotinib for second-line treatment of Chinese patients with advanced squamous cell carcinoma of the lung
Shun Lu, Wei Li, Caicun Zhou, Cheng-Ping Hu, Shukui Qin, Gang Cheng, Jifeng Feng, Jie Wang, Agnieszka Cseh, Barbara Peil, Neil Gibson, Eva Ehrnrooth & Li Zhang
Pages: 8565-8573
Published online: 30 Nov 2018
AbstractforAfatinib vs erlotinib for second-line treatment of Chinese patients with advanced squamous cell carcinoma of the lung | Full Text | References | PDF (862.3 KB)
  • 65 Views
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Article
Afatinib versus gemcitabine/cisplatin for first-line treatment of Chinese patients with advanced non-small-cell lung cancer harboring EGFR mutations: subgroup analysis of the LUX-Lung 6 trial
Yi-Long Wu, Chong-Rui Xu, Cheng-Ping Hu, Jifeng Feng, Shun Lu, Yunchao Huang, Wei Li, Mei Hou, Jian Hua Shi, Angela Märten, Jean Fan, Barbara Peil & Caicun Zhou
Pages: 8575-8587
Published online: 30 Nov 2018
AbstractforAfatinib versus gemcitabine/cisplatin for first-line treatment of Chinese patients with advanced non-small-cell lung cancer harboring EGFR mutations: subgroup analysis of the LUX-Lung 6 trial | Full Text | References | PDF (1 MB)
  • 106 Views
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Case Report

Case Report
A novel BCR-ABL1 mutation in a patient with Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia
Raquel Vinhas, Alexandra Lourenço, Susana Santos, Marcos Lemos, Patrícia Ribeiro, Aida Botelho de Sousa, Pedro Viana Baptista & Alexandra Ramos Fernandes
Pages: 8589-8598
Published online: 30 Nov 2018
AbstractforA novel BCR-ABL1 mutation in a patient with Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia | Full Text | References | PDF (2.5 MB)
  • 77 Views
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Case Report
Intestinal metastasis from breast invasive ductal carcinoma after a long latency: case report and literature review
Min Liu, Lei Zhang, Liang Guo, Jincai Lv, Weiyan Shi & Bailong Liu
Pages: 8599-8603
Published online: 03 Dec 2018
AbstractforIntestinal metastasis from breast invasive ductal carcinoma after a long latency: case report and literature review | Full Text | References | PDF (5.6 MB)
  • 58 Views
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Review

Review Article
Efficacy and safety of bevacizumab-based combination therapy for treatment of patients with metastatic colorectal cancer
Ran Xu, Chen Xu, Chuntong Liu, Can Cui & Jing Zhu
Pages: 8605-8621
Published online: 04 Dec 2018
AbstractforEfficacy and safety of bevacizumab-based combination therapy for treatment of patients with metastatic colorectal cancer | Full Text | References | PDF (1.4 MB)
  • 73 Views
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Original Research

Article
Efficacy and safety of PD1/PDL1 blockades versus docetaxel in patients with pretreated advanced non-small-cell lung cancer: a meta-analysis
Jixiang Liu, Yulan Zhong, Shanshan Peng, Xiangxiang Zhou & Xin Gan
Pages: 8623-8632
Published online: 03 Dec 2018
AbstractforEfficacy and safety of PD1/PDL1 blockades versus docetaxel in patients with pretreated advanced non-small-cell lung cancer: a meta-analysis | Full Text | References | PDF (931.8 KB)
  • 45 Views
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Article
Natural product pectolinarigenin inhibits proliferation, induces apoptosis, and causes G2/M phase arrest of HCC via PI3K/AKT/mTOR/ERK signaling pathway
Tianchun Wu, Xiaogang Dong, Dongdong Yu, Zhenhua Shen, Jinbei Yu & Sheng Yan
Pages: 8633-8642
Published online: 03 Dec 2018
AbstractforNatural product pectolinarigenin inhibits proliferation, induces apoptosis, and causes G2/M phase arrest of HCC via PI3K/AKT/mTOR/ERK signaling pathway | Full Text | References | PDF (4.7 MB)
  • 89 Views
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Article
miR-222-3p promotes osteosarcoma cell migration and invasion through targeting TIMP3
Jianping Guo, Quanxiang Liu, Zengxin Li, Haifeng Guo, Changshuang Bai & Fajia Wang
Pages: 8643-8653
Published online: 03 Dec 2018
AbstractformiR-222-3p promotes osteosarcoma cell migration and invasion through targeting TIMP3 | Full Text | References | PDF (4.8 MB)
  • 64 Views
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Article
A peptide-CpG-DNA-liposome complex vaccine targeting TM4SF5 suppresses growth of pancreatic cancer in a mouse allograft model
Sangkyu Park, Dongbum Kim, Guang Wu, Harry Jung, Jeong-A Park, Hyung-Joo Kwon & Younghee Lee
Pages: 8655-8672
Published online: 03 Dec 2018
AbstractforA peptide-CpG-DNA-liposome complex vaccine targeting TM4SF5 suppresses growth of pancreatic cancer in a mouse allograft model | Full Text | References | PDF (3.3 MB)
  • 125 Views
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Article
Expression of activating transcription factor 5 (ATF5) is increased in astrocytomas of different WHO grades and correlates with survival of glioblastoma patients
Jonas Feldheim, Almuth F Kessler, Dominik Schmitt, Lara Wilczek, Thomas Linsenmann, Mathias Dahlmann, Camelia M Monoranu, Ralf-Ingo Ernestus, Carsten Hagemann & Mario Löhr
Pages: 8673-8684
Published online: 04 Dec 2018
AbstractforExpression of activating transcription factor 5 (ATF5) is increased in astrocytomas of different WHO grades and correlates with survival of glioblastoma patients | Full Text | References | PDF (812.1 KB)
  • 72 Views
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Article
Application of preoperative three-dimensional model design in radioactive particle implantation for advanced pancreatic cancer
Yang Liu, Shao-Cheng Lyu, Xian-Qiang Wang & Yan-Bin Wang
Pages: 8685-8693
Published online: 04 Dec 2018
AbstractforApplication of preoperative three-dimensional model design in radioactive particle implantation for advanced pancreatic cancer | Full Text | References | PDF (2.1 MB)
  • 44 Views
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Article
MiR-411 suppresses the development of bladder cancer by regulating ZnT1
Yang Liu, Tao Liu, Hongwei Jin, Lei Yin, Hongyuan Yu & Jianbin Bi
Pages: 8695-8704
Published online: 04 Dec 2018
AbstractforMiR-411 suppresses the development of bladder cancer by regulating ZnT1 | Full Text | References | PDF (2.5 MB)
  • 85 Views
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Case Report

Case Report
Clinical benefit from afatinib in an advanced squamous cell lung carcinoma patient harboring HER2 S310Y mutation: a case report
Yan Gao, Aihong Zheng, Xiuming Zhu, Jia Song & Qian Xue
Pages: 8705-8710
Published online: 05 Dec 2018
AbstractforClinical benefit from afatinib in an advanced squamous cell lung carcinoma patient harboring HER2 S310Y mutation: a case report | Full Text | References | PDF (11 MB)
  • 59 Views
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Original Research

Article
Development and validation of a prognostic signature for preoperative prediction of overall survival in gastric cancer patients
Minggu Zhu, Qicai Wang, Zhaowen Luo, Kelong Liu & Zhiqiao Zhang
Pages: 8711-8722
Published online: 04 Dec 2018
AbstractforDevelopment and validation of a prognostic signature for preoperative prediction of overall survival in gastric cancer patients | Full Text | References | PDF (1.5 MB)
  • 53 Views
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Case Report

Case Report
Pathological complete response induced by neoadjuvant treatment using BRAF and MEK inhibitors in a patient with unresectable BRAF V600E-mutant malignant melanoma of the gallbladder
Zhou Yu, Elisa Quiroz, Yulei Shen & Ishmael A Jaiyesimi
Pages: 8723-8728
Published online: 04 Dec 2018
AbstractforPathological complete response induced by neoadjuvant treatment using BRAF and MEK inhibitors in a patient with unresectable BRAF V600E-mutant malignant melanoma of the gallbladder | Full Text | References | PDF (2 MB)
  • 61 Views
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Original Research

Article
MALAT1 promotes proliferation, migration, and invasion of MG63 cells by upregulation of TGIF2 via negatively regulating miR-129
Kai Liu, Yingang Zhang, Liang Liu & Qiling Yuan
Pages: 8729-8740
Published online: 14 Nov 2022
AbstractforMALAT1 promotes proliferation, migration, and invasion of MG63 cells by upregulation of TGIF2 via negatively regulating miR-129 | Full Text | References | PDF (2 MB)
  • 49 Views
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Article
Overexpression of NELFCD promotes colorectal cancer cells proliferation, migration, and invasion
Shenglei Song, Daojiang Li, Chunxing Yang, Peicheng Yan, Yang Bai, Yi Zhang, Gui Hu, Changwei Lin & Xiaorong Li
Pages: 8741-8750
Published online: 05 Dec 2018
AbstractforOverexpression of NELFCD promotes colorectal cancer cells proliferation, migration, and invasion | Full Text | References | PDF (3.1 MB)
  • 66 Views
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Article
Inhibition of XIAP increases carboplatin sensitivity in ovarian cancer
Yiping Zhang, Furong Huang, Qingyu Luo, Xiaowei Wu, Zhihua Liu, Hongyan Chen & Yinghui Huang
Pages: 8751-8759
Published online: 05 Dec 2018
AbstractforInhibition of XIAP increases carboplatin sensitivity in ovarian cancer | Full Text | References | PDF (4 MB)
  • 94 Views
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Article
SFRP5 inhibits the migration and invasion of melanoma cells through Wnt signaling pathway
Yangmei Chen, Daopei Zou, Nan Wang, Tao Tan, Yu Liu, Qing Zhao, Yihuan Pu, Rabin Jung Thapa & Jin Chen
Pages: 8761-8772
Published online: 06 Dec 2018
AbstractforSFRP5 inhibits the migration and invasion of melanoma cells through Wnt signaling pathway | Full Text | References | PDF (16.9 MB)
  • 81 Views
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Article
miR-1 inhibits the proliferation of breast cancer stem cells by targeting EVI-1
Lei Wu, Tianyi Wang, Dongning He, Xiaoxi Li & Youhong Jiang
Pages: 8773-8781
Published online: 06 Dec 2018
AbstractformiR-1 inhibits the proliferation of breast cancer stem cells by targeting EVI-1 | Full Text | References | PDF (2.7 MB)
  • 86 Views
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Article
PIWI-like protein 1 upregulation promotes gastric cancer invasion and metastasis
Chun-li Gao, Rui Sun, Dong-hai Li & Fei Gong
Pages: 8783-8789
Published online: 06 Dec 2018
AbstractforPIWI-like protein 1 upregulation promotes gastric cancer invasion and metastasis | Full Text | References | PDF (1.6 MB)
  • 106 Views
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Article
MicroRNA 486-3p directly targets BIK and regulates apoptosis and invasion in colorectal cancer cells
Li Feng, Li Jing, Jing Han, Guiying Wang, Yan Liu, Xue Zhang, Yudong Wang, Feifei Wang, Hongqing Ma & Yibing Liu
Pages: 8791-8801
Published online: 06 Dec 2018
AbstractforMicroRNA 486-3p directly targets BIK and regulates apoptosis and invasion in colorectal cancer cells | Full Text | References | PDF (16.1 MB)
  • 48 Views
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Article
TRIM37 promotes cell invasion and metastasis by regulating SIP1-mediated epithelial–mesenchymal transition in gastric cancer
Dehu Chen, Xiaolan You, Yan Pan, Qinghong Liu & Gan Cao
Pages: 8803-8813
Published online: 10 Dec 2018
AbstractforTRIM37 promotes cell invasion and metastasis by regulating SIP1-mediated epithelial–mesenchymal transition in gastric cancer | Full Text | References | PDF (1.8 MB)
  • 57 Views
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Article
TSPAN7 promotes the migration and proliferation of lung cancer cells via epithelial-to-mesenchymal transition
Xianguo Wang, Min Lin, Jinping Zhao, Shaoping Zhu, Ming Xu & Xuefeng Zhou
Pages: 8815-8822
Published online: 13 Dec 2018
AbstractforTSPAN7 promotes the migration and proliferation of lung cancer cells via epithelial-to-mesenchymal transition | Full Text | References | PDF (1.9 MB)
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Article
Antimetastatic effect of epigenetic drugs, hydralazine and valproic acid, in Ras-transformed NIH 3T3 cells
Enrique Pérez-Cárdenas, Lucía Taja-Chayeb, Catalina Trejo-Becerril, José Chanona-Vilchis, Alma Chávez-Blanco, Guadalupe Domínguez-Gómez, Elizabeth Langley, Alejandro García-Carrancá & Alfonso Dueñas-González
Pages: 8823-8833
Published online: 07 Dec 2018
AbstractforAntimetastatic effect of epigenetic drugs, hydralazine and valproic acid, in Ras-transformed NIH 3T3 cells | Full Text | References | PDF (1.2 MB)
  • 121 Views
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Article
Transcatheter hepatic arterial chemoembolization plus cinobufotalin injection adjuvant therapy for advanced hepatocellular carcinoma: a meta-analysis of 27 trials involving 2,079 patients
Na Guo, Yanyan Miao & Mingzhong Sun
Pages: 8835-8853
Published online: 14 Nov 2022
AbstractforTranscatheter hepatic arterial chemoembolization plus cinobufotalin injection adjuvant therapy for advanced hepatocellular carcinoma: a meta-analysis of 27 trials involving 2,079 patients | Full Text | References | PDF (3.5 MB)
  • 50 Views
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Article
Overexpressing lncRNA SNHG16 inhibited HCC proliferation and chemoresistance by functionally sponging hsa-miR-93
Fengfeng Xu, Guoqing Zha, Yanpeng Wu, Weilong Cai & Jian Ao
Pages: 8855-8863
Published online: 07 Dec 2018
AbstractforOverexpressing lncRNA SNHG16 inhibited HCC proliferation and chemoresistance by functionally sponging hsa-miR-93 | Full Text | References | PDF (1.3 MB)
  • 81 Views
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Article
miRNA-19 promotes non-small-cell lung cancer cell proliferation via inhibiting CBX7 expression
Xiaogang Peng, Li Guan & Baoan Gao
Pages: 8865-8874
Published online: 07 Dec 2018
AbstractformiRNA-19 promotes non-small-cell lung cancer cell proliferation via inhibiting CBX7 expression | Full Text | References | PDF (3.3 MB)
  • 59 Views
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Article
Overexpression of CD300A inhibits progression of NSCLC through downregulating Wnt/β-catenin pathway
Ze Tang, Hongfei Cai, Rui Wang & Youbin Cui
Pages: 8875-8883
Published online: 07 Dec 2018
AbstractforOverexpression of CD300A inhibits progression of NSCLC through downregulating Wnt/β-catenin pathway | Full Text | References | PDF (3.5 MB)
  • 74 Views
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Article
Predictive value of positron emission tomography for the prognosis of molecularly targeted therapy in solid tumors
Xianhe Xie, Huijuan Chen, Haitao Yang, Heng Lin, Sijing Zhou, Ruifen Shen, Cuiping Lu, Liting Ling, Wanzun Lin & Ziyuan Liao
Pages: 8885-8899
Published online: 07 Dec 2018
AbstractforPredictive value of positron emission tomography for the prognosis of molecularly targeted therapy in solid tumors | Full Text | References | PDF (3.1 MB)
  • 50 Views
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Article
Drug–target–disease network analysis of gene–phenotype connectivity for genistein in ovarian cancer
Chen Zhang, Fan Yang, Suiqin Ni, Wenbing Teng & Yingxia Ning
Pages: 8901-8908
Published online: 14 Nov 2022
AbstractforDrug–target–disease network analysis of gene–phenotype connectivity for genistein in ovarian cancer | Full Text | References | PDF (2.7 MB)
  • 71 Views
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Case Report

Case Report
Good local tumor control but lethal hemorrhage after apatinib treatment for intractable squamous carcinoma of the floor of the mouth: a case report
Xiaopeng Zhu, Min Liu, Jincai Lv, Liang Guo, Cheng Li, Lihua Dong & Bailong Liu
Pages: 8909-8913
Published online: 07 Dec 2018
AbstractforGood local tumor control but lethal hemorrhage after apatinib treatment for intractable squamous carcinoma of the floor of the mouth: a case report | Full Text | References | PDF (2.1 MB)
  • 53 Views
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Original Research

Article
The potential functions of FAM46C in oral squamous cell carcinoma
Xiaohua Zhuang & Mengmeng Lu
Pages: 8915-8923
Published online: 10 Dec 2018
AbstractforThe potential functions of FAM46C in oral squamous cell carcinoma | Full Text | References | PDF (2.4 MB)
  • 53 Views
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Review

Review Article
Osteopontin versus alpha-fetoprotein as a diagnostic marker for hepatocellular carcinoma: a meta-analysis
Tingting Sun, Yurong Tang, Diwen Sun, Qingao Bu & Peng Li
Pages: 8925-8935
Published online: 10 Dec 2018
AbstractforOsteopontin versus alpha-fetoprotein as a diagnostic marker for hepatocellular carcinoma: a meta-analysis | Full Text | References | PDF (1.5 MB)
  • 74 Views
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Case Series

Coincident primary breast lymphoma and gastrointestinal stromal tumor: case series and molecular mechanisms
Ethan B Ludmir, Tyler Gutschenritter, Chelsea C Pinnix, Jillian R Gunther, Loretta J Nastoupil, Joseph D Khoury, L Jeffrey Medeiros, Bouthaina S Dabaja & Sarah A Milgrom
Pages: 8937-8942
Published online: 10 Dec 2018
AbstractforCoincident primary breast lymphoma and gastrointestinal stromal tumor: case series and molecular mechanisms | Full Text | References | PDF (2 MB)
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Corrigendum

Correction
A small compound spindlactone A sensitizes human endometrial cancer cells to TRAIL-induced apoptosis via the inhibition of NAD(P)H dehydrogenase quinone 1 [Corrigendum]
Page: 8943
Published online: 10 Dec 2018
CitationforA small compound spindlactone A sensitizes human endometrial cancer cells to TRAIL-induced apoptosis via the inhibition of NAD(P)H dehydrogenase quinone 1 [Corrigendum] | Full Text | PDF (144.7 KB)
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Case Report

Case Report
Therapeutic decision based on molecular detection of resistance mechanism in an ALK-rearranged lung cancer patient: a case report
Elisa De Carlo, Monica Schiappacassi, Martina Urbani, Roberto Doliana, Gustavo Baldassarre, Valentina Da Ros, Sandra Santarossa, Emanuela Chimienti, Eleonora Berto, Lucia Fratino & Alessandra Bearz
Pages: 8945-8950
Published online: 10 Dec 2018
AbstractforTherapeutic decision based on molecular detection of resistance mechanism in an ALK-rearranged lung cancer patient: a case report | Full Text | References | PDF (728.3 KB)
  • 45 Views
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Original Research

Article
MIIP is downregulated in gastric cancer and its forced expression inhibits proliferation and invasion of gastric cancer cells in vitro and in vivo
Dan Sun, Yiwei Wang, Shanshan Jiang, Gang Wang & Yan Xin
Pages: 8951-8964
Published online: 11 Dec 2018
AbstractforMIIP is downregulated in gastric cancer and its forced expression inhibits proliferation and invasion of gastric cancer cells in vitro and in vivo | Full Text | References | PDF (8.3 MB)
  • 65 Views
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Article
RETRACTED ARTICLE: miRNA-641 inhibits the proliferation, migration, and invasion and induces apoptosis of cervical cancer cells by directly targeting ZEB1
Rui Yao, Huzhong Zheng, Liqun Wu & Pingsheng Cai
Pages: 8965-8976
Published online: 11 Dec 2018
AbstractforRETRACTED ARTICLE: miRNA-641 inhibits the proliferation, migration, and invasion and induces apoptosis of cervical cancer cells by directly targeting ZEB1 | PDF (3 MB)
  • 19 Views
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Article
Celastrol induces ubiquitin-dependent degradation of mTOR in breast cancer cells
Xiaoli Li, Guangbei Zhu, Xintong Yao, Ning Wang, Ronghui Hu, Qingxin Kong, Duanfang Zhou, Liangyuan Long, Jiali Cai & Weiying Zhou
Pages: 8977-8985
Published online: 11 Dec 2018
AbstractforCelastrol induces ubiquitin-dependent degradation of mTOR in breast cancer cells | Full Text | References | PDF (1.1 MB)
  • 86 Views
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Case Report

Case Report
c.1439delA frameshift deletion mutation in familial adenomatous polyposis
De-Jian Ma, Bi-Shi Wang, Jin-Bo Yue, Zeng-Jun Li & Yan-Lai Sun
Pages: 8987-8993
Published online: 11 Dec 2018
Abstractforc.1439delA frameshift deletion mutation in familial adenomatous polyposis | Full Text | References | PDF (1.6 MB)
  • 47 Views
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Original Research

Article
Resveratrol induces apoptosis in human melanoma cell through negatively regulating Erk/PKM2/Bcl-2 axis
Hailong Zhao, Limin Han, Yi Jian, Yuntao Ma, Wanyue Yan, Xiaowen Chen, Haiyan Xu & Lijuan Li
Pages: 8995-9006
Published online: 11 Dec 2018
AbstractforResveratrol induces apoptosis in human melanoma cell through negatively regulating Erk/PKM2/Bcl-2 axis | Full Text | References | PDF (5.1 MB)
  • 136 Views
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Case Report

Case Report
A primary retroperitoneal anaplastic lymphoma kinase-positive anaplastic large cell lymphoma with tumor thrombosis
Jisong Li, Xiaodong Tian, Mangju Wang, Wei Liu, Xiaochao Guo, Ke Wang, Lin Nong, Wei Wang & Yinmo Yang
Pages: 9007-9011
Published online: 12 Dec 2018
AbstractforA primary retroperitoneal anaplastic lymphoma kinase-positive anaplastic large cell lymphoma with tumor thrombosis | Full Text | References | PDF (5.2 MB)
  • 62 Views
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Original Research

Article
RETRACTED ARTICLE: microRNA-769 is downregulated in colorectal cancer and inhibits cancer progression by directly targeting cyclin-dependent kinase 1
Lei Wang, Minyi Xu, Pei Lu & Fangfang Zhou
Pages: 9013-9025
Published online: 12 Dec 2018
AbstractforRETRACTED ARTICLE: microRNA-769 is downregulated in colorectal cancer and inhibits cancer progression by directly targeting cyclin-dependent kinase 1 | PDF (3.6 MB)
  • 11 Views
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Case Report

Case Report
Pseudomyxoma extraperitonei in horseshoe kidney masquerading as renal hilar tumor: a case report
Xin Wang, Xiang Gao, Liang Wang, Zhihong Dai, Bo Fan, Haoyu Cui & Zhiyu Liu
Pages: 9027-9032
Published online: 12 Dec 2018
AbstractforPseudomyxoma extraperitonei in horseshoe kidney masquerading as renal hilar tumor: a case report | Full Text | References | PDF (3.3 MB)
  • 41 Views
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Original Research

Article
Curative effectiveness and safety of osimertinib in the treatment for non-small-cell lung cancer: a meta-analysis of the experimental evidence
Peng Chen, Fuchao Chen, Jiexin Lei & Benhong Zhou
Pages: 9033-9047
Published online: 14 Nov 2022
AbstractforCurative effectiveness and safety of osimertinib in the treatment for non-small-cell lung cancer: a meta-analysis of the experimental evidence | Full Text | References | PDF (1.3 MB)
  • 73 Views
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Review

Review Article
Early and late outcomes of bevacizumab plus chemotherapy versus chemotherapy alone as a neoadjuvant treatment in HER2-negative nonmetastatic breast cancer: a meta-analysis of randomized controlled trials
Jinli Wei, Yulin Luo & Deyuan Fu
Pages: 9049-9059
Published online: 12 Dec 2018
AbstractforEarly and late outcomes of bevacizumab plus chemotherapy versus chemotherapy alone as a neoadjuvant treatment in HER2-negative nonmetastatic breast cancer: a meta-analysis of randomized controlled trials | Full Text | References | PDF (1,023.1 KB)
  • 48 Views
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Review Article
The effect of additional chemotherapy on high-risk prostate cancer: a systematic review and meta-analysis
Junru Chen, Xingming Zhang, Guangxi Sun, Jinge Zhao, Jiandong Liu, Peng Zhao, Jindong Dai, Pengfei Shen & Hao Zeng
Pages: 9061-9070
Published online: 13 Dec 2018
AbstractforThe effect of additional chemotherapy on high-risk prostate cancer: a systematic review and meta-analysis | Full Text | References | PDF (832.8 KB)
  • 64 Views
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Original Research

Article
Risk factors for lymph node metastasis and the impact of adjuvant chemotherapy on ductal carcinoma in situ with microinvasion: a population-based study
Cong Chen, Shumin Huang, Aihua Huang, Yunlu Jia, Ji Wang, Zeqin Zhang, Misha Mao, Linbo Wang & Jichun Zhou
Pages: 9071-9080
Published online: 13 Dec 2018
AbstractforRisk factors for lymph node metastasis and the impact of adjuvant chemotherapy on ductal carcinoma in situ with microinvasion: a population-based study | Full Text | References | PDF (604.6 KB)
  • 71 Views
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Review

Review Article
Encorafenib/binimetinib for the treatment of BRAF-mutant advanced, unresectable, or metastatic melanoma: design, development, and potential place in therapy
James Sun, Jonathan S Zager & Zeynep Eroglu
Pages: 9081-9089
Published online: 14 Dec 2018
AbstractforEncorafenib/binimetinib for the treatment of BRAF-mutant advanced, unresectable, or metastatic melanoma: design, development, and potential place in therapy | Full Text | References | PDF (212.1 KB)
  • 371 Views
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Original Research

Article
miRNA-30c can be used as a target in the diagnosis and treatment of osteosarcoma
Rongxin Sun, Aikeremujiang Muheremu & Yihe Hu
Pages: 9091-9099
Published online: 14 Dec 2018
AbstractformiRNA-30c can be used as a target in the diagnosis and treatment of osteosarcoma | Full Text | References | PDF (2.3 MB)
  • 78 Views
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Article
Natural antisense transcript of hypoxia-inducible factor 1 regulates hypoxic cell apoptosis in epithelial ovarian cancer
Jun-jun Qiu, Xiao-jing Lin, Ting-ting Zheng, Xiao-yan Tang & Ke-qin Hua
Pages: 9101-9110
Published online: 14 Dec 2018
AbstractforNatural antisense transcript of hypoxia-inducible factor 1 regulates hypoxic cell apoptosis in epithelial ovarian cancer | Full Text | References | PDF (3.1 MB)
  • 58 Views
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Rapid Communication

Article
Next-generation sequencing of circulating tumor DNA for detection of gene mutations in lung cancer: implications for precision treatment
Jinhuo Lai, Bin Du, Yao Wang, Riping Wu & Zongyang Yu
Pages: 9111-9116
Published online: 14 Nov 2022
AbstractforNext-generation sequencing of circulating tumor DNA for detection of gene mutations in lung cancer: implications for precision treatment | Full Text | References | PDF (199.6 KB)
  • 103 Views
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