Figures & data
Figure 1 The structure of caveolae.
Notes: Caveolae are 50–100 nm Ω-shaped, cholesterol-enriched, rigid membrane microdomains that are composed of scaffold proteins named caveolins. The most important constituent protein is Caveolin-1.
Figure 2 Cav1 and breast cancer prognosis.
Notes: CAFs and epithelium Cav1 expression may be primary prognostic indicators for breast cancer patients. Loss of CAFs Cav1 expression and high expression levels of epithelium Cav1 often show a poor clinical outcome. Moreover, cytoplasmic EGFR and stromal MCT-4 may be secondary prognostic indicators.
Abbreviations: CAFs, cancer-associated fibroblasts; Cav1, caveolin-1; MCT-4, monocarboxylate transporter 4.
Table 1 The role of Cav1 in breast cancer cells tumorigenesis
Table 2 The role of Cav1 in breast cancer tissues tumorigenesis
Figure 3 Cav1 acts both as a suppressor and a promoter in breast cancer cell tumorigenesis.
Notes: Cav1 can act as a suppressor in breast cancer cell carcinogenic process via suppressing breast cancer cell proliferation, autophagy, invasion and migration and promoting apoptosis. Cav1 can also act as a promoter in breast cancer cell carcinogenic process via promoting breast cancer cell proliferation, autophagy, invasion, migration and metastasis, and suppressing apoptosis and anoikis.
Abbreviations: BKCa, large conductance Ca2+-activated potassium; Cav1, caveolin-1; CSF1, colony-stimulating factor 1; EMT, epithelial to mesenchymal transition; FSP-1, fibroblast-specific protein-1; HER2, human epidermal growth factor receptor-2; HSP90, heat shock protein 90; MMP, matrix metalloproteinase; MT4-MMP, membrane type 4 matrix metalloproteinase; VEGF, vascular endothelial growth factor; SDF-1, stromal cell-derived factor-1.
