OncoTargets and Therapy, Volume 12, Issue (2019)

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OncoTargets and Therapy, Volume 12, Issue (2019)

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Corrigendum

Correction
β-elemene inhibits radiation and hypoxia-induced macrophages infiltration via Prx-1/NF-κB/HIF-1α signaling pathway [Corrigendum]
Pages: mmmmmmmdccxiii-mmmmmmmdccxiv
Published online: 19 Sep 2019
Citationforβ-elemene inhibits radiation and hypoxia-induced macrophages infiltration via Prx-1/NF-κB/HIF-1α signaling pathway [Corrigendum] | Full Text | PDF (1.4 MB)
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Correction
LncRNA PVT1 promotes proliferation, invasion and epithelial–mesenchymal transition of renal cell carcinoma cells through downregulation of miR-16-5p [Corrigendum]
Pages: mmmmmmmdccxxxvii-mmmmmmmdccxxxviii
Published online: 20 Sep 2019
CitationforLncRNA PVT1 promotes proliferation, invasion and epithelial–mesenchymal transition of renal cell carcinoma cells through downregulation of miR-16-5p [Corrigendum] | Full Text | PDF (2.4 MB)
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Original Research

Article
Upregulation of circulating miR130a is correlated with development of Barrett’s esophagus and esophageal adenocarcinoma
Li Wang, Feng Ji, Gang Liu, Wei Wang, Zhitong Li, Yongqiang Yue & Zhonggao Wang
Pages: 1-7
Published online: 17 Dec 2018
AbstractforUpregulation of circulating miR130a is correlated with development of Barrett’s esophagus and esophageal adenocarcinoma | Full Text | References | PDF (989.4 KB)
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Open Access

Rapid Communication

Article
Pain predicts overall survival in men with metastatic castration-resistant prostate cancer treated with radium-223
Giandomenico Roviello, Rosj Gallicchio, Giovanni Bozza, Maria Grazia Rodriquenz, Michele Aieta & Giovanni Storto
Pages: 9-13
Published online: 17 Dec 2018
AbstractforPain predicts overall survival in men with metastatic castration-resistant prostate cancer treated with radium-223 | Full Text | References | PDF (338.1 KB)
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Open Access

Case Report

Case Report
Ceritinib for an anaplastic lymphoma kinase rearrangement-positive patient previously treated with alectinib with poor performance status
Rui Kitadai, Yusuke Okuma & Shoko Kawai
Pages: 15-19
Published online: 17 Dec 2018
AbstractforCeritinib for an anaplastic lymphoma kinase rearrangement-positive patient previously treated with alectinib with poor performance status | Full Text | References | PDF (918.8 KB)
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Original Research

Article
Methotrexate-induced apoptosis in human ovarian adenocarcinoma SKOV-3 cells via ROS-mediated bax/bcl-2-cyt-c release cascading
Gadah AlBasher, Abdullah A AlKahtane, Saud Alarifi, Daoud Ali, Mohammed S Alessia, Rafa S Almeer, Mohamed M Abdel-Daim, Nouf K Al-Sultan, Ahmed A Al-Qahtani, Huma Ali & Saad Alkahtani
Pages: 21-30
Published online: 17 Dec 2018
AbstractforMethotrexate-induced apoptosis in human ovarian adenocarcinoma SKOV-3 cells via ROS-mediated bax/bcl-2-cyt-c release cascading | Full Text | References | PDF (3.2 MB)
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Open Access
Article
Upregulation of syncytin-1 promotes invasion and metastasis by activating epithelial-mesenchymal transition-related pathway in endometrial carcinoma
Changmin Liu, Jiqin Xu, Feifei Wen, Fangfang Yang, Xiaoming Li, Dianzhong Geng, Lei Li, Jiming Chen & Jing Zheng
Pages: 31-40
Published online: 17 Dec 2018
AbstractforUpregulation of syncytin-1 promotes invasion and metastasis by activating epithelial-mesenchymal transition-related pathway in endometrial carcinoma | Full Text | References | PDF (4.9 MB)
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Open Access
Article
MicroRNA-562 negatively regulated c-MET/AKT pathway in the growth of glioblastoma cells
Xiaohu Nie, Zhongzhou Su, Renfu Yan, Ai Yan, Sheng Qiu & Yue Zhou
Pages: 41-49
Published online: 21 Dec 2018
AbstractforMicroRNA-562 negatively regulated c-MET/AKT pathway in the growth of glioblastoma cells | Full Text | References | PDF (2.1 MB)
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Case Report

Case Report
Newly emergent acquired EGFR exon 18 G724S mutation after resistance of a T790M specific EGFR inhibitor osimertinib in non-small-cell lung cancer: a case report
Yan Zhang, Bixiu He, Dongbo Zhou, Min Li & Chengping Hu
Pages: 51-56
Published online: 18 Dec 2018
AbstractforNewly emergent acquired EGFR exon 18 G724S mutation after resistance of a T790M specific EGFR inhibitor osimertinib in non-small-cell lung cancer: a case report | Full Text | References | PDF (423.2 KB)
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Case Report
Use of anlotinib in intra-abdominal desmoplastic small round cell tumors: a case report and literature review
Hui-Min Chen & Ge Feng
Pages: 57-61
Published online: 18 Dec 2018
AbstractforUse of anlotinib in intra-abdominal desmoplastic small round cell tumors: a case report and literature review | Full Text | References | PDF (1.3 MB)
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Original Research

Article
Targeting CDC7 improves sensitivity to chemotherapy of esophageal squamous cell carcinoma
Ji-Xiang Cao & Yao Lu
Pages: 63-74
Published online: 20 Dec 2018
AbstractforTargeting CDC7 improves sensitivity to chemotherapy of esophageal squamous cell carcinoma | Full Text | References | PDF (3.8 MB)
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Open Access
Article
Long noncoding RNA LINC01296 promotes cancer-cell proliferation and metastasis in urothelial carcinoma of the bladder
Xiaofei Wang, Lei Wang, Yanbing Gong, Zhenzhen Liu, Yingchao Qin, Jia Chen & Ningcheng Li
Pages: 75-85
Published online: 19 Dec 2018
AbstractforLong noncoding RNA LINC01296 promotes cancer-cell proliferation and metastasis in urothelial carcinoma of the bladder | Full Text | References | PDF (3 MB)
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Open Access
Article
Tanshinol inhibits the growth, migration and invasion of hepatocellular carcinoma cells via regulating the PI3K-AKT signaling pathway
Pingting Zhu, Zhaoguo Liu, JiaoJiao Zhou & Yuanyuan Chen
Pages: 87-99
Published online: 19 Dec 2018
AbstractforTanshinol inhibits the growth, migration and invasion of hepatocellular carcinoma cells via regulating the PI3K-AKT signaling pathway | Full Text | References | PDF (5.7 MB)
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Open Access
Article
RETRACTED ARTICLE: Long noncoding RNA SNHG15 serves as an oncogene and predicts poor prognosis in epithelial ovarian cancer
Chong Qu, Chunmei Dai, Yahua Guo, Rui Qin & Junbao Liu
Pages: 101-111
Published online: 19 Dec 2018
AbstractforRETRACTED ARTICLE: Long noncoding RNA SNHG15 serves as an oncogene and predicts poor prognosis in epithelial ovarian cancer | PDF (1.3 MB)
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Case Report

Case Report
Individualized treatment for a case of recurrent ovarian ependymoma
Zhen Yuan, Mei Yu & Yu Chen
Pages: 113-117
Published online: 20 Dec 2018
AbstractforIndividualized treatment for a case of recurrent ovarian ependymoma | Full Text | References | PDF (853 KB)
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Original Research

Article
RASSF1A promoter methylation correlates development, progression, and poor cancer-specific survival of renal cell carcinoma: trial sequential analysis
Qianfeng Zhuang, Zhen Chen, Jie Shen, Min Fan, Dong Xue, Hao Lu, Renfang Xu & Xiaozhou He
Pages: 119-134
Published online: 20 Dec 2018
AbstractforRASSF1A promoter methylation correlates development, progression, and poor cancer-specific survival of renal cell carcinoma: trial sequential analysis | Full Text | References | PDF (2.1 MB)
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Open Access
Article
Long non-coding RNA DANCR promotes the progression of non-small-cell lung cancer by inhibiting p21 expression
Lanfang Guo, Jianmei Gu, Sinan Hou, Dabiao Liu, Mengjie Zhou, Tengjiang Hua, Jinye Zhang, Zhijun Ge & Jing Xu
Pages: 135-146
Published online: 21 Dec 2018
AbstractforLong non-coding RNA DANCR promotes the progression of non-small-cell lung cancer by inhibiting p21 expression | Full Text | References | PDF (2.4 MB)
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Open Access
Article
Overexpression of lncRNA PTENP1 suppresses glioma cell proliferation and metastasis in vitro
Su Hu, Li Xu, Lihua Li, Dongdong Luo, Hailin Zhao, Dan Li & Biao Peng
Pages: 147-156
Published online: 21 Dec 2018
AbstractforOverexpression of lncRNA PTENP1 suppresses glioma cell proliferation and metastasis in vitro | Full Text | References | PDF (6.9 MB)
  • 80 Views
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Open Access
Article
Analysis of long non-coding RNAs in glioblastoma for prognosis prediction using weighted gene co-expression network analysis, Cox regression, and L1-LASSO penalization
Ruqing Liang, Yaqin Zhi, Guizhi Zheng, Bin Zhang, Hua Zhu & Meng Wang
Pages: 157-168
Published online: 21 Dec 2018
AbstractforAnalysis of long non-coding RNAs in glioblastoma for prognosis prediction using weighted gene co-expression network analysis, Cox regression, and L1-LASSO penalization | Full Text | References | PDF (6.3 MB)
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Open Access
Article
LncRNA SNHG5 promotes growth and invasion in melanoma by regulating the miR-26a-5p/TRPC3 pathway
Jun Gao, Kang Zeng, Yi Liu, Lin Gao & Lishi Liu
Pages: 169-179
Published online: 24 Dec 2018
AbstractforLncRNA SNHG5 promotes growth and invasion in melanoma by regulating the miR-26a-5p/TRPC3 pathway | Full Text | References | PDF (2.5 MB)
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Open Access
Article
The diagnostic accuracy of liquid exosomes for lung cancer detection: a meta-analysis
Zhipeng Song, Saisai Wang & Yang Liu
Pages: 181-192
Published online: 24 Dec 2018
AbstractforThe diagnostic accuracy of liquid exosomes for lung cancer detection: a meta-analysis | Full Text | References | PDF (1.4 MB)
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Review

Review Article
Critical factors in chimeric antigen receptor-modified T-cell (CAR-T) therapy for solid tumors
Lingli Yan & Bainan Liu
Pages: 193-204
Published online: 24 Dec 2018
AbstractforCritical factors in chimeric antigen receptor-modified T-cell (CAR-T) therapy for solid tumors | Full Text | References | PDF (483 KB)
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Original Research

Article
RETRACTED ARTICLE: miR-125a restrains cell migration and invasion by targeting STAT3 in gastric cancer cells
Liu Yang, Shuguang Zhang, Kai Guo, Hu Huang, Shuai Qi, Jie Yao & Zhihong Zhang
Pages: 205-215
Published online: 24 Dec 2018
AbstractforRETRACTED ARTICLE: miR-125a restrains cell migration and invasion by targeting STAT3 in gastric cancer cells | PDF (2.6 MB)
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Open Access
Article
CUX2 functions as an oncogene in papillary thyroid cancer
Yihan Sun, Danrong Ye, Yuefeng Li, Endong Chen, Rutian Hao, Yefeng Cai, Qingxuan Wang, Ouchen Wang & Xiaohua Zhang
Pages: 217-224
Published online: 24 Dec 2018
AbstractforCUX2 functions as an oncogene in papillary thyroid cancer | Full Text | References | PDF (2.2 MB)
  • 50 Views
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Open Access
Article
The use of regorafenib for patients with refractory metastatic colorectal cancer in clinical practice
Sang Eun Yoon, Su Jin Lee, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Ho Yeong Lim, Won Ki Kang, Young Suk Park & Seung Tae Kim
Pages: 225-231
Published online: 24 Dec 2018
AbstractforThe use of regorafenib for patients with refractory metastatic colorectal cancer in clinical practice | Full Text | References | PDF (373.7 KB)
  • 41 Views
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Open Access
Article
DEAD-box helicase 27 plays a tumor-promoter role by regulating the stem cell-like activity of human colorectal cancer cells
Chunxing Yang, Daojiang Li, Yang Bai, Shenglei Song, Peicheng Yan, Runliu Wu, Yi Zhang, Gui Hu, Changwei Lin, Xiaorong Li & Lihuang Huang
Pages: 233-241
Published online: 28 Dec 2018
AbstractforDEAD-box helicase 27 plays a tumor-promoter role by regulating the stem cell-like activity of human colorectal cancer cells | Full Text | References | PDF (2.3 MB)
  • 43 Views
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Open Access
Article
Upregulation of valosin-containing protein (VCP) is associated with poor prognosis and promotes tumor progression of orbital B-cell lymphoma
Wenwen Zhu, Di Li & Lihua Xiao
Pages: 243-253
Published online: 27 Dec 2018
AbstractforUpregulation of valosin-containing protein (VCP) is associated with poor prognosis and promotes tumor progression of orbital B-cell lymphoma | Full Text | References | PDF (5.2 MB)
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Erratum

Correction
Circ-DLG 1 promotes the proliferation of esophageal squamous cell carcinoma [Erratum]
Page: 255
Published online: 27 Dec 2018
CitationforCirc-DLG 1 promotes the proliferation of esophageal squamous cell carcinoma [Erratum] | Full Text | PDF (98.9 KB)
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Original Research

Article
Evodiamine inactivates NF-κB and potentiates the antitumor effects of gemcitabine on tongue cancer both in vitro and in vivo
Qi Guo, Yanmei Liu, Jiayuan Zhao, Jing Wang, Yue Li, Yunqing Pang, Jian Chen & Jing Wang
Pages: 257-267
Published online: 27 Dec 2018
AbstractforEvodiamine inactivates NF-κB and potentiates the antitumor effects of gemcitabine on tongue cancer both in vitro and in vivo | Full Text | References | PDF (2.4 MB)
  • 53 Views
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Open Access
Article
Should S-1 be better than capecitabine for patients with advanced gastric cancer in Asia? A systematic review and meta-analysis
Ziqi Ye, Jie Chen, Yuefeng Rao & Wenchao Yang
Pages: 269-277
Published online: 27 Dec 2018
AbstractforShould S-1 be better than capecitabine for patients with advanced gastric cancer in Asia? A systematic review and meta-analysis | Full Text | References | PDF (1.1 MB)
  • 29 Views
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Article
CD4+ CD25+ regulatory T cells promote hepatocellular carcinoma invasion via TGF-β1-induced epithelial–mesenchymal transition
Chunying Shi, Ying Chen, Yaodong Chen, Yuchuan Yang, Wang Bing & Jiping Qi
Pages: 279-289
Published online: 28 Dec 2018
AbstractforCD4+ CD25+ regulatory T cells promote hepatocellular carcinoma invasion via TGF-β1-induced epithelial–mesenchymal transition | Full Text | References | PDF (3 MB)
  • 84 Views
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Open Access
Article
Contribution of FPR and TLR9 to hypoxia-induced chemoresistance of ovarian cancer cells
Yongqing Cai, Jian Huang, Haiyan Xing, Bin Li, Ling Li, Xianfeng Wang, Dan Peng & Jianhong Chen
Pages: 291-301
Published online: 28 Dec 2018
AbstractforContribution of FPR and TLR9 to hypoxia-induced chemoresistance of ovarian cancer cells | Full Text | References | PDF (1.7 MB)
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Review

Review Article
Evaluating ivosidenib for the treatment of relapsed/refractory AML: design, development, and place in therapy
Samah Nassereddine, Coen J Lap & Imad A Tabbara
Pages: 303-308
Published online: 28 Dec 2018
AbstractforEvaluating ivosidenib for the treatment of relapsed/refractory AML: design, development, and place in therapy | Full Text | References | PDF (206.3 KB)
  • 92 Views
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Original Research

Article
MiR-6991-3p is identified as a novel suppressor in the expansion and activation of myeloid-derived suppressor cells in hepatoma-bearing mice
Jin-Ping Sun, Quan-Xing Ge, Zheng Ren, Xin-Fang Sun & Shu-Ping Xie
Pages: 309-317
Published online: 28 Dec 2018
AbstractforMiR-6991-3p is identified as a novel suppressor in the expansion and activation of myeloid-derived suppressor cells in hepatoma-bearing mice | Full Text | References | PDF (1.1 MB)
  • 29 Views
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Review

Review Article
Toward fully exploiting the therapeutic potential of marketed pharmaceuticals: the use of octreotide and chloroquine in oncology
Panagiota Papanagnou, Georgios E Papadopoulos, Theodora Stivarou & Anastasios Pappas
Pages: 319-339
Published online: 31 Dec 2018
AbstractforToward fully exploiting the therapeutic potential of marketed pharmaceuticals: the use of octreotide and chloroquine in oncology | Full Text | References | PDF (2.3 MB)
  • 56 Views
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Original Research

Article
Combination of TPF regimen and cinobufotalin inhibits proliferation and induces apoptosis in human hypopharyngeal and laryngeal squamous cell carcinoma cells
Xixi Shen, Yong Tao, Yifan Yang, Ru Wang, Jugao Fang & Meng Lian
Pages: 341-348
Published online: 31 Dec 2018
AbstractforCombination of TPF regimen and cinobufotalin inhibits proliferation and induces apoptosis in human hypopharyngeal and laryngeal squamous cell carcinoma cells | Full Text | References | PDF (926 KB)
  • 38 Views
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Open Access
Article
Comparison of the diagnostic performance of fluorescence in situ hybridization (FISH), nuclear matrix protein 22 (NMP22), and their combination model in bladder carcinoma detection: a systematic review and meta-analysis
Qindong Liang, Guangjie Zhang, Wuxian Li, Jing Wang & Shangchun Sheng
Pages: 349-358
Published online: 31 Dec 2018
AbstractforComparison of the diagnostic performance of fluorescence in situ hybridization (FISH), nuclear matrix protein 22 (NMP22), and their combination model in bladder carcinoma detection: a systematic review and meta-analysis | Full Text | References | PDF (698.9 KB)
  • 58 Views
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Article
Serum cytoskeleton-associated protein 4 as a biomarker for the diagnosis of hepatocellular carcinoma
Yu Wang, Weixin Yu, Mingqing He, Yan Huang, Mingyue Wang & Jinzhou Zhu
Pages: 359-364
Published online: 31 Dec 2018
AbstractforSerum cytoskeleton-associated protein 4 as a biomarker for the diagnosis of hepatocellular carcinoma | Full Text | References | PDF (547.2 KB)
  • 44 Views
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Review

Review Article
The progression of HMGB1-induced autophagy in cancer biology
Tianwei Xu, Lihua Jiang & Zhaoxia Wang
Pages: 365-377
Published online: 31 Dec 2018
AbstractforThe progression of HMGB1-induced autophagy in cancer biology | Full Text | References | PDF (732.2 KB)
  • 124 Views
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Original Research

Article
Targeted neoadjuvant therapy in the HER-2-positive breast cancer patients: a systematic review and meta-analysis
Wenhua Ma, Fugang Zhao, Changpeng Zhou, Yongqian Zhang, Yingchun Zhao, Na Li & Peng Xie
Pages: 379-390
Published online: 03 Jan 2019
AbstractforTargeted neoadjuvant therapy in the HER-2-positive breast cancer patients: a systematic review and meta-analysis | Full Text | References | PDF (1.2 MB)
  • 34 Views
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Review

Review Article
CART cell therapy for prostate cancer: status and promise
Haiyuan Yu, Jun Pan, Zhicheng Guo, Chunhua Yang & Lijun Mao
Pages: 391-395
Published online: 03 Jan 2019
AbstractforCART cell therapy for prostate cancer: status and promise | Full Text | References | PDF (651 KB)
  • 154 Views
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Original Research

Article
TRIM28 activates autophagy and promotes cell proliferation in glioblastoma
Yong Peng, Mingming Zhang, Zhongzhong Jiang & Yugang Jiang
Pages: 397-404
Published online: 03 Jan 2019
AbstractforTRIM28 activates autophagy and promotes cell proliferation in glioblastoma | Full Text | References | PDF (2.2 MB)
  • 44 Views
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Open Access
Article
rs187960998 polymorphism in miR-211 prevents development of human colon cancer by deregulation of 3′UTR in CHD5
Limei Zhu, Ran Wang, Li Zhang, Chunlei Zuo, Rui Zhang & Shaolin Zhao
Pages: 405-412
Published online: 03 Jan 2019
Abstractforrs187960998 polymorphism in miR-211 prevents development of human colon cancer by deregulation of 3′UTR in CHD5 | Full Text | References | PDF (4.1 MB)
  • 35 Views
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Corrigendum

Correction
PLK1 as a potential prognostic marker of gastric cancer through MEK-ER K pathway on PDTX models [Corrigendum]
Page: 413
Published online: 03 Jan 2019
CitationforPLK1 as a potential prognostic marker of gastric cancer through MEK-ER K pathway on PDTX models [Corrigendum] | Full Text | PDF (100.6 KB)
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Original Research

Article
Long noncoding RNA SNHG16 induces sorafenib resistance in hepatocellular carcinoma cells through sponging miR-140-5p
Junfeng Ye, Ruoyan Zhang, Xiaohong Du, Wengang Chai & Qiang Zhou
Pages: 415-422
Published online: 04 Jan 2019
AbstractforLong noncoding RNA SNHG16 induces sorafenib resistance in hepatocellular carcinoma cells through sponging miR-140-5p | Full Text | References | PDF (1.1 MB)
  • 33 Views
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Open Access
Article
lncRNA CASC9 regulates cell migration and invasion in hemangioma endothelial cells by targeting miR-125a-3p/Nrg1
Xianwei Li, Bo Chen, Decai Chi, Yingnan Zhang & Weiliang Jiang
Pages: 423-432
Published online: 07 Jan 2019
AbstractforlncRNA CASC9 regulates cell migration and invasion in hemangioma endothelial cells by targeting miR-125a-3p/Nrg1 | Full Text | References | PDF (2.9 MB)
  • 29 Views
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Open Access
Article
RETRACTED ARTICLE: miR-302 cluster inhibits angiogenesis and growth of K562 leukemia cells by targeting VEGFA
Jiang Cao, Li Li, Xiao Han, Hai Cheng, Wei Chen, Kunming Qi, Chong Chen, Qingyun Wu, Mingshan Niu, Lingyu Zeng & Kailin Xu
Pages: 433-441
Published online: 08 Jan 2019
AbstractforRETRACTED ARTICLE: miR-302 cluster inhibits angiogenesis and growth of K562 leukemia cells by targeting VEGFA | PDF (4.1 MB)
  • 9 Views
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Case Report

Case Report
Complete response with fluorouracil and irinotecan with a BRAFV600E and EGFR inhibitor in BRAF-mutated metastatic colorectal cancer: a case report
Zhan Wang, Wei-Ping Dai & Yuan-Sheng Zang
Pages: 443-447
Published online: 08 Jan 2019
AbstractforComplete response with fluorouracil and irinotecan with a BRAFV600E and EGFR inhibitor in BRAF-mutated metastatic colorectal cancer: a case report | Full Text | References | PDF (549.4 KB)
  • 47 Views
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Original Research

Article
Nodal staging score and adequacy of nodal staging
Hui-Min Chen & Ge Feng
Pages: 449-455
Published online: 08 Jan 2019
AbstractforNodal staging score and adequacy of nodal staging | Full Text | References | PDF (581.8 KB)
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Article
Diagnostic value of multiple tumor-associated autoantibodies in lung cancer
Rui Zhang, Li Ma, Weiying Li, Shijie Zhou & Shaofa Xu
Pages: 457-469
Published online: 09 Jan 2019
AbstractforDiagnostic value of multiple tumor-associated autoantibodies in lung cancer | Full Text | References | PDF (1 MB)
  • 40 Views
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Open Access
Article
The anthelmintic drug flubendazole induces cell apoptosis and inhibits NF-κB signaling in esophageal squamous cell carcinoma
Jiali Tao, Hongmei Zhao, Xiaochen Xie, Man Luo, Zhiwei Gao, Hong Sun & Ziming Huang
Pages: 471-478
Published online: 09 Jan 2019
AbstractforThe anthelmintic drug flubendazole induces cell apoptosis and inhibits NF-κB signaling in esophageal squamous cell carcinoma | Full Text | References | PDF (4.6 MB)
  • 37 Views
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Review

Review Article
Diagnostic significance of miR-210 as a potential tumor biomarker of human cancer detection: an updated pooled analysis of 30 articles
Song Feng, Anbang He, Deli Wang & Bin Kang
Pages: 479-493
Published online: 09 Jan 2019
AbstractforDiagnostic significance of miR-210 as a potential tumor biomarker of human cancer detection: an updated pooled analysis of 30 articles | Full Text | References | PDF (2 MB)
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Original Research

Article
Long noncoding RNA UCA1 targets miR-582-5p and contributes to the progression and drug resistance of bladder cancer cells through ATG7-mediated autophagy inhibition
Junfeng Wu, Wei Li, Jinzhuo Ning, Weimin Yu, Ting Rao & Fan Cheng
Pages: 495-508
Published online: 09 Jan 2019
AbstractforLong noncoding RNA UCA1 targets miR-582-5p and contributes to the progression and drug resistance of bladder cancer cells through ATG7-mediated autophagy inhibition | Full Text | References | PDF (2.3 MB)
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Open Access
Article
Celastrol inhibits colorectal cancer through TGF-β1/Smad signaling
Zhitao Jiang, Qianyu Cao, Guoliang Dai, Jianchun Wang, Chundi Liu, Lingyan Lv & Jinhuo Pan
Pages: 509-518
Published online: 09 Jan 2019
AbstractforCelastrol inhibits colorectal cancer through TGF-β1/Smad signaling | Full Text | References | PDF (2.5 MB)
  • 43 Views
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Open Access
Article
Correlation between high-resolution computed tomography lung nodule characteristics and EGFR mutation in lung adenocarcinomas
Yunqiang Nie, Hongjun Liu, Xiao Tan, Hui Wang, Fuzhou Li, Cuiyun Li, Ping Han, Xin Lyv, Xinyi Xu & Miao Guo
Pages: 519-526
Published online: 10 Jan 2019
AbstractforCorrelation between high-resolution computed tomography lung nodule characteristics and EGFR mutation in lung adenocarcinomas | Full Text | References | PDF (1.2 MB)
  • 38 Views
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Open Access
Article
Clinical significance of miR-195 in hepatocellular carcinoma and its biological function in tumor progression
Xiaoyan Chen & Angang Wang
Pages: 527-534
Published online: 10 Jan 2019
AbstractforClinical significance of miR-195 in hepatocellular carcinoma and its biological function in tumor progression | Full Text | References | PDF (853.2 KB)
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Case Report

Case Report
Merkel cell carcinoma of the thigh: case report and review of the literature
Wen Jiang, Jiali Xu, Rong Wang, Tingting Wang, Yongqian Shu & Lianke Liu
Pages: 535-540
Published online: 11 Jan 2019
AbstractforMerkel cell carcinoma of the thigh: case report and review of the literature | Full Text | References | PDF (1.9 MB)
  • 35 Views
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Original Research

Article
Should we apply sorafenib in hepatocellular carcinoma patients with microvascular invasion after curative hepatectomy?
Yun Huang, Zeyu Zhang, Yufan Zhou, Jiajin Yang, Kuan Hu & Zhiming Wang
Pages: 541-548
Published online: 11 Jan 2019
AbstractforShould we apply sorafenib in hepatocellular carcinoma patients with microvascular invasion after curative hepatectomy? | Full Text | References | PDF (439.9 KB)
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Review

Review Article
Epigenetic mechanism and target therapy of UHRF1 protein complex in malignancies
Busheng Xue, Jiansong Zhao, Penghui Feng, Jia Xing, Hongliang Wu & Yan Li
Pages: 549-559
Published online: 11 Jan 2019
AbstractforEpigenetic mechanism and target therapy of UHRF1 protein complex in malignancies | Full Text | References | PDF (2.4 MB)
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Original Research

Article
Comprehensive analysis of potential prognostic genes for the construction of a competing endogenous RNA regulatory network in hepatocellular carcinoma
Chaosen Yue, Yaoyao Ren, Hua Ge, Chaojie Liang, Yingchen Xu, Guangming Li & Jixiang Wu
Pages: 561-576
Published online: 14 Jan 2019
AbstractforComprehensive analysis of potential prognostic genes for the construction of a competing endogenous RNA regulatory network in hepatocellular carcinoma | Full Text | References | PDF (2.4 MB)
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Article
Effect of CD44st and HER2 expression on the postoperative prognosis of breast cancer patients
Dan Dan Chen, Jun An Ji, Hai Cui Yan, Guan Hong Huang & Xin Jian Fang
Pages: 577-585
Published online: 15 Jan 2019
AbstractforEffect of CD44st and HER2 expression on the postoperative prognosis of breast cancer patients | Full Text | References | PDF (1.2 MB)
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Article
Scutellarin inhibits the metastasis and cisplatin resistance in glioma cells
Shi-lei Tang, Yuan-lin Gao & Wen-zhong Hu
Pages: 587-598
Published online: 15 Jan 2019
AbstractforScutellarin inhibits the metastasis and cisplatin resistance in glioma cells | Full Text | References | PDF (1.9 MB)
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Article
miR-4262, low level of which predicts poor prognosis, targets proto-oncogene CD163 to suppress cell proliferation and invasion in gastric cancer
Hongzhi Zhang, Huijuan Jiang, Huixiang Zhang, Juncai Liu, Xigang Hu & Lei Chen
Pages: 599-607
Published online: 15 Jan 2019
AbstractformiR-4262, low level of which predicts poor prognosis, targets proto-oncogene CD163 to suppress cell proliferation and invasion in gastric cancer | Full Text | References | PDF (822.8 KB)
  • 28 Views
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Article
Pharmacological inhibition of USP7 promotes antitumor immunity and contributes to colon cancer therapy
Changqing Fu, Xiaojue Zhu, Peiqi Xu & Yonghao Li
Pages: 609-617
Published online: 15 Jan 2019
AbstractforPharmacological inhibition of USP7 promotes antitumor immunity and contributes to colon cancer therapy | Full Text | References | PDF (3.5 MB)
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Case Report

Case Report
Ureteral metastasis of non-small-cell lung cancer: a case report
Fan Ren, Minghui Liu, Xiaoqian Xu, Hongbing Zhang, Xin Li, Jinghao Liu & Jun Chen
Pages: 619-623
Published online: 15 Jan 2019
AbstractforUreteral metastasis of non-small-cell lung cancer: a case report | Full Text | References | PDF (5.2 MB)
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Original Research

Article
RAP80 expression in breast cancer and its relationship with apoptosis in breast cancer cells
Guanghua Jin, Xiaoyun Mao, Zhen Qiao, Bo Chen & Feng Jin
Pages: 625-634
Published online: 18 Jan 2019
AbstractforRAP80 expression in breast cancer and its relationship with apoptosis in breast cancer cells | Full Text | References | PDF (2 MB)
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Review

Review Article
Ponatinib: a novel multi-tyrosine kinase inhibitor against human malignancies
Fiona H Tan, Tracy L Putoczki, Stanley S Stylli & Rodney B Luwor
Pages: 635-645
Published online: 18 Jan 2019
AbstractforPonatinib: a novel multi-tyrosine kinase inhibitor against human malignancies | Full Text | References | PDF (279 KB)
  • 156 Views
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Original Research

Article
Long non-coding RNA LINC00662 promotes proliferation and migration in oral squamous cell carcinoma
Debin Xu, Yunmei Chen, Chunlei Yuan, Shuyong Zhang & Wei Peng
Pages: 647-656
Published online: 18 Jan 2019
AbstractforLong non-coding RNA LINC00662 promotes proliferation and migration in oral squamous cell carcinoma | Full Text | References | PDF (3.2 MB)
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Open Access
Article
The lncRNA ZEB2-AS1 is upregulated in gastric cancer and affects cell proliferation and invasion via miR-143-5p/HIF-1α axis
Fangxiong Wu, Hongyan Gao, Kaige Liu, Baohua Gao, Hezhuang Ren, Zheng Li & Fengrui Liu
Pages: 657-667
Published online: 18 Jan 2019
AbstractforThe lncRNA ZEB2-AS1 is upregulated in gastric cancer and affects cell proliferation and invasion via miR-143-5p/HIF-1α axis | Full Text | References | PDF (1.7 MB)
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Article
Comparing short-time outcomes of three-dimensional and two-dimensional totally laparoscopic surgery for colon cancer using overlapped delta-shaped anastomosis
Hao Su, Weisen Jin, Peng Wang, Mandula Bao, Xuewei Wang, Chuanduo Zhao, Xishan Wang, Zhixiang Zhou & Haitao Zhou
Pages: 669-675
Published online: 18 Jan 2019
AbstractforComparing short-time outcomes of three-dimensional and two-dimensional totally laparoscopic surgery for colon cancer using overlapped delta-shaped anastomosis | Full Text | References | PDF (728.2 KB)
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Review

Review Article
Role of radiotherapy in the treatment of metastatic head and neck cancer
Rafael Ordoñez, Ana Otero, Inmaculada Jerez, Jose A Medina, Yolanda Lupiañez-Pérez & Jaime Gomez-Millan
Pages: 677-683
Published online: 18 Jan 2019
AbstractforRole of radiotherapy in the treatment of metastatic head and neck cancer | Full Text | References | PDF (221.7 KB)
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Original Research

Article
Expression of NR1H3 in endometrial carcinoma and its effect on the proliferation of Ishikawa cells in vitro
Fang Fang, Dawei Li, Lu Zhao, Yue Li, Teng Zhang & Baoxia Cui
Pages: 685-697
Published online: 18 Jan 2019
AbstractforExpression of NR1H3 in endometrial carcinoma and its effect on the proliferation of Ishikawa cells in vitro | Full Text | References | PDF (1.9 MB)
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Open Access
Article
RETRACTED ARTICLE: LncRNA SNHG16 drives proliferation and invasion of papillary thyroid cancer through modulation of miR-497
Qiang Wen, Lina Zhao, Tongtong Wang, Ningning Lv, Xuejiao Cheng, Guang Zhang & Lin Bai
Pages: 699-708
Published online: 18 Jan 2019
AbstractforRETRACTED ARTICLE: LncRNA SNHG16 drives proliferation and invasion of papillary thyroid cancer through modulation of miR-497 | PDF (2.6 MB)
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Open Access
Article
Combining data from TCGA and GEO databases and reverse transcription quantitative PCR validation to identify gene prognostic markers in lung cancer
Xiao Liu, Jun Wang, Mei Chen, Shilan Liu, Xiaodan Yu & Fuqiang Wen
Pages: 709-720
Published online: 21 Jan 2019
AbstractforCombining data from TCGA and GEO databases and reverse transcription quantitative PCR validation to identify gene prognostic markers in lung cancer | Full Text | References | PDF (2.4 MB)
  • 71 Views
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Article
Anticancer activity of 1,25-(OH)2D3 against human breast cancer cell lines by targeting Ras/MEK/ERK pathway
Wei Zheng, Lin Cao, Linna Ouyang, Qian Zhang, Bofeng Duan, Wei Zhou, Shan Chen, Wei Peng, Yi Xie, Qing Fan & Daoxing Gong
Pages: 721-732
Published online: 22 Jan 2019
AbstractforAnticancer activity of 1,25-(OH)2D3 against human breast cancer cell lines by targeting Ras/MEK/ERK pathway | Full Text | References | PDF (5.4 MB)
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Review

Review Article
Comparison of neoadjuvant therapy and upfront surgery in resectable pancreatic cancer: a meta-analysis and systematic review
Xiaohan Ren, Xiyi Wei, Yichao Ding, Feng Qi, Yundi Zhang, Xin Hu, Chao Qin & Xiao Li
Pages: 733-744
Published online: 22 Jan 2019
AbstractforComparison of neoadjuvant therapy and upfront surgery in resectable pancreatic cancer: a meta-analysis and systematic review | Full Text | References | PDF (1 MB)
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Case Report

Case Report
Acquisition of T790M resistance mutation in a patient with advanced adenocarcinoma harbouring uncommon EGFR mutations: a case report and literature review
Taiki Hakozaki & Makiko Yomota
Pages: 745-748
Published online: 22 Jan 2019
AbstractforAcquisition of T790M resistance mutation in a patient with advanced adenocarcinoma harbouring uncommon EGFR mutations: a case report and literature review | Full Text | References | PDF (155 KB)
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Perspectives

Article
miR-124, a potential therapeutic target in colorectal cancer
Zhen Qin & Xia Liu
Pages: 749-751
Published online: 22 Jan 2019
AbstractformiR-124, a potential therapeutic target in colorectal cancer | Full Text | References | PDF (222.7 KB)
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Case Report

Case Report
Radiotherapy in advanced glottic laryngeal carcinoma in a patient with Wegener’s granulomatosis: how much radiation dose is needed?
Grazia Lazzari, Alessandra Briatico Vangosa, Maria Assunta De Cillis & Giovanni Silvano
Pages: 753-757
Published online: 23 Jan 2019
AbstractforRadiotherapy in advanced glottic laryngeal carcinoma in a patient with Wegener’s granulomatosis: how much radiation dose is needed? | Full Text | References | PDF (498.4 KB)
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Original Research

Article
RETRACTED ARTICLE: MicroRNA-217 acts as a tumor suppressor and correlates with the chemoresistance of cervical carcinoma to cisplatin
Zhaojun Yin & Weiru Ren
Pages: 759-771
Published online: 23 Jan 2019
AbstractforRETRACTED ARTICLE: MicroRNA-217 acts as a tumor suppressor and correlates with the chemoresistance of cervical carcinoma to cisplatin | PDF (3 MB)
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Article
Fenofibrate potentiates chemosensitivity to human breast cancer cells by modulating apoptosis via AKT/NF-κB pathway
Jianguo Sun, Zhibao Zheng, Qi Chen, Yin Pan, Mingming Quan & Yuechu Dai
Pages: 773-783
Published online: 23 Jan 2019
AbstractforFenofibrate potentiates chemosensitivity to human breast cancer cells by modulating apoptosis via AKT/NF-κB pathway | Full Text | References | PDF (2.3 MB)
  • 56 Views
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Article
G-protein-signaling modulator 2 expression and role in a CD133+ pancreatic cancer stem cell subset
Sheng-Chun Dang, Xiao-Bao Qian, Wei Jin, Lei Cui, Ji-Xiang Chen & Min Gu
Pages: 785-794
Published online: 23 Jan 2019
AbstractforG-protein-signaling modulator 2 expression and role in a CD133+ pancreatic cancer stem cell subset | Full Text | References | PDF (1.1 MB)
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Open Access
Article
MicroRNA-505 suppresses gastric cancer cell proliferation and invasion by directly targeting Polo-like kinase-1
Sheng-Chun Dang, Fei Wang, Xiao-Bao Qian, Malik Abdul, Qais-Ahmad Naseer, Wei Jin, Rong Hu, Qian Gu & Min Gu
Pages: 795-803
Published online: 24 Jan 2019
AbstractforMicroRNA-505 suppresses gastric cancer cell proliferation and invasion by directly targeting Polo-like kinase-1 | Full Text | References | PDF (6.5 MB)
  • 40 Views
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Article
lncRNA small nucleolar RNA host gene 20 predicts poor prognosis in glioma and promotes cell proliferation by silencing P21
Xiang-Sheng Li, Fa-Zheng Shen, Li-Yong Huang, Lei Hui, Rui-Hua Liu, Yan-Juan Ma & Bao-Zhe Jin
Pages: 805-814
Published online: 24 Jan 2019
AbstractforlncRNA small nucleolar RNA host gene 20 predicts poor prognosis in glioma and promotes cell proliferation by silencing P21 | Full Text | References | PDF (1.2 MB)
  • 30 Views
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Open Access
Article
Avasimibe inhibits tumor growth by targeting FoxM1-AKR1C1 in osteosarcoma
Liang Wang, Yang Liu & Guanzhen Yu
Pages: 815-823
Published online: 24 Jan 2019
AbstractforAvasimibe inhibits tumor growth by targeting FoxM1-AKR1C1 in osteosarcoma | Full Text | References | PDF (1.7 MB)
  • 42 Views
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Article
RETRACTED ARTICLE: The inhibitive effect of sh-HIF1A-AS2 on the proliferation, invasion, and pathological damage of breast cancer via targeting miR-548c-3p through regulating HIF-1α/VEGF pathway in vitro and vivo
Xiao Guo, Shenghai Lee & Peilong Cao
Pages: 825-834
Published online: 24 Jan 2019
AbstractforRETRACTED ARTICLE: The inhibitive effect of sh-HIF1A-AS2 on the proliferation, invasion, and pathological damage of breast cancer via targeting miR-548c-3p through regulating HIF-1α/VEGF pathway in vitro and vivo | PDF (6.2 MB)
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Article
miRNA-101-5p inhibits the growth and aggressiveness of NSCLC cells through targeting CXCL6
Qi Chen, Dan Liu, Zhi Hu, Cheng Luo & Si Lin Zheng
Pages: 835-848
Published online: 25 Jan 2019
AbstractformiRNA-101-5p inhibits the growth and aggressiveness of NSCLC cells through targeting CXCL6 | Full Text | References | PDF (5.2 MB)
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Open Access
Article
MiR-206 inhibits proliferation, migration, and invasion of gastric cancer cells by targeting the MUC1 gene
Min Deng, Yiyu Qin, Xiaodong Chen, Qizhi Wang & Jianchao Wang
Pages: 849-859
Published online: 25 Jan 2019
AbstractforMiR-206 inhibits proliferation, migration, and invasion of gastric cancer cells by targeting the MUC1 gene | Full Text | References | PDF (2.8 MB)
  • 43 Views
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Article
Efficacy and safety of nivolumab for metastatic biliary tract cancer
Miaomiao Gou, Yong Zhang, Haiyan Si & Guanghai Dai
Pages: 861-867
Published online: 25 Jan 2019
AbstractforEfficacy and safety of nivolumab for metastatic biliary tract cancer | Full Text | References | PDF (633.3 KB)
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Article
Downregulation of CENPK suppresses hepatocellular carcinoma malignant progression through regulating YAP1
Jianlin Wang, Haimin Li, Congcong Xia, Xisheng Yang, Bin Dai, Kaishan Tao & Kefeng Dou
Pages: 869-882
Published online: 29 Jan 2019
AbstractforDownregulation of CENPK suppresses hepatocellular carcinoma malignant progression through regulating YAP1 | Full Text | References | PDF (6.6 MB)
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Open Access
Article
Cryptotanshinone inhibits esophageal squamous-cell carcinoma in vitro and in vivo through the suppression of STAT3 activation
Yubin Ji, Yichen Liu, Nina Xue, Tingting Du, Liyuan Wang, Rui Huang, Ling Li, Chunhong Yan & Xiaoguang Chen
Pages: 883-896
Published online: 29 Jan 2019
AbstractforCryptotanshinone inhibits esophageal squamous-cell carcinoma in vitro and in vivo through the suppression of STAT3 activation | Full Text | References | PDF (3.8 MB)
  • 45 Views
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Article
Reversing platinum resistance in ovarian cancer multicellular spheroids by targeting Bcl-2
Ya’nan Yang, Song Li, Yiting Sun, Di Zhang, Zeyi Zhao & Lian Liu
Pages: 897-906
Published online: 29 Jan 2019
AbstractforReversing platinum resistance in ovarian cancer multicellular spheroids by targeting Bcl-2 | Full Text | References | PDF (5.5 MB)
  • 51 Views
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Article
RETRACTED ARTICLE: microRNA-628 inhibits the proliferation of acute myeloid leukemia cells by directly targeting IGF-1R
Lu Chen, Xin Jiang, Haoyue Chen, Qiaoyan Han, Chunhua Liu & Miao Sun
Pages: 907-919
Published online: 29 Jan 2019
AbstractforRETRACTED ARTICLE: microRNA-628 inhibits the proliferation of acute myeloid leukemia cells by directly targeting IGF-1R | PDF (2.4 MB)
  • 9 Views
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Article
Establishing a detection method for CCNY: a potentially significant clinical investigative marker in NSCLC patients
Li Ma, Meng Gu, Yu Teng & Weiying Li
Pages: 921-932
Published online: 29 Jan 2019
AbstractforEstablishing a detection method for CCNY: a potentially significant clinical investigative marker in NSCLC patients | Full Text | References | PDF (858.5 KB)
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Article
Effects of combined inhibition of STAT3 and VEGFR2 pathways on the radiosensitivity of non-small-cell lung cancer cells
Chenxi Hu, Wei Zhuang, Yun Qiao, Bin Liu, Liang Liu, Kaiyuan Hui & Xiaodong Jiang
Pages: 933-944
Published online: 29 Jan 2019
AbstractforEffects of combined inhibition of STAT3 and VEGFR2 pathways on the radiosensitivity of non-small-cell lung cancer cells | Full Text | References | PDF (7 MB)
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Open Access
Article
The expression of special AT-rich binding protein 1 in cervical cancer and its clinical significance
Lijie Zhao, Yuhua Zheng, Yong Ji & Xiaoying Zhang
Pages: 945-951
Published online: 30 Jan 2019
AbstractforThe expression of special AT-rich binding protein 1 in cervical cancer and its clinical significance | Full Text | References | PDF (443 KB)
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Case Report

Case Report
The coexistence of a Wilms’ tumor and renal cell carcinoma in children: a case report and review of the literature
Xiao-Ping Zou, Yao-Ying Jiang, Yan Liao, Yi-Wu Dang, Gang Chen, Zhen-Bo Feng & Yun Ma
Pages: 953-958
Published online: 30 Jan 2019
AbstractforThe coexistence of a Wilms’ tumor and renal cell carcinoma in children: a case report and review of the literature | Full Text | References | PDF (5 MB)
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Original Research

Article
Efficacy and safety of targeted therapy for metastatic HER2-positive breast cancer in the first-line treatment: a Bayesian network meta-analysis
Fubin Feng, Tingting Zhang, Fang Yin, Cun Liu, Jing Zhuang, Lingyu Qi, Xue Wang, Jia Li, Lu Wang, Jinhui Tian & Changgang Sun
Pages: 959-974
Published online: 31 Jan 2019
AbstractforEfficacy and safety of targeted therapy for metastatic HER2-positive breast cancer in the first-line treatment: a Bayesian network meta-analysis | Full Text | References | PDF (1.7 MB)
  • 56 Views
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Article
miR-135a suppresses migration of gastric cancer cells by targeting TRAF5-mediated NF-κB activation
Yongzheng Xie, Fangjun Li, Zheng Li & Zhaohui Shi
Pages: 975-984
Published online: 01 Feb 2019
AbstractformiR-135a suppresses migration of gastric cancer cells by targeting TRAF5-mediated NF-κB activation | Full Text | References | PDF (1.8 MB)
  • 38 Views
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Open Access
Article
Hypertension as a predictive biomarker in patients with advanced non-small-cell lung cancer treated with apatinib
Shen-Cun Fang, Wen Huang, Ying-Ming Zhang, Hai-Tao Zhang & Wei-Ping Xie
Pages: 985-992
Published online: 01 Feb 2019
AbstractforHypertension as a predictive biomarker in patients with advanced non-small-cell lung cancer treated with apatinib | Full Text | References | PDF (373.9 KB)
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Open Access
Article
Longdaysin inhibits Wnt/β-catenin signaling and exhibits antitumor activity against breast cancer
Yanpeng Xiong, Liang Zhou, Zijie Su, Jiaxing Song, Qi Sun, Shan-Shan Liu, Yuqing Xia, Zhongyuan Wang & Desheng Lu
Pages: 993-1005
Published online: 05 Feb 2019
AbstractforLongdaysin inhibits Wnt/β-catenin signaling and exhibits antitumor activity against breast cancer | Full Text | References | PDF (3.6 MB)
  • 40 Views
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Article
Downregulated expression of RACK1 results in pancreatic cancer growth and metastasis
Lei Zhang, Yang Lv, Yefei Rong, Wenqi Chen, Yuan Fang, Weilin Mao, Wenhui Lou, Dayong Jin & Xuefeng Xu
Pages: 1007-1020
Published online: 01 Feb 2019
AbstractforDownregulated expression of RACK1 results in pancreatic cancer growth and metastasis | Full Text | References | PDF (2.6 MB)
  • 35 Views
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Article
HIFU is safe, effective, and feasible in pancreatic cancer patients: a monocentric retrospective study among 523 patients
Zhouyu Ning, Jing Xie, Qiwen Chen, Chenyue Zhang, Litao Xu, Libin Song & Zhiqiang Meng
Pages: 1021-1029
Published online: 01 Feb 2019
AbstractforHIFU is safe, effective, and feasible in pancreatic cancer patients: a monocentric retrospective study among 523 patients | Full Text | References | PDF (747.6 KB)
  • 60 Views
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Open Access
Article
ZNF433 positively regulates the beta-catenin/ TCF pathway in prostate cancer and enhances the tumorigenicity of cancer cells
Shuo Gu, Peijin Hou, Kun Liu, Xiaobing Niu, Bingjian Wei, Fei Mao & Zongyuan Xu
Pages: 1031-1039
Published online: 01 Feb 2019
AbstractforZNF433 positively regulates the beta-catenin/ TCF pathway in prostate cancer and enhances the tumorigenicity of cancer cells | Full Text | References | PDF (9.7 MB)
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Open Access

Retraction

Retraction
The lncRNA TUG1 promotes epithelial ovarian cancer cell proliferation and invasion via the WNT/β-catenin pathway [Retraction]
Page: 1041
Published online: 04 Feb 2019
CitationforThe lncRNA TUG1 promotes epithelial ovarian cancer cell proliferation and invasion via the WNT/β-catenin pathway [Retraction] | Full Text | PDF (109.6 KB)
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Original Research

Article
RETRACTED ARTICLE: Overexpressed long noncoding RNA TUG1 affects the cell cycle, proliferation, and apoptosis of pancreatic cancer partly through suppressing RND3 and MT2A
Bingqing Hui, Yetao Xu, Benpeng Zhao, Hao Ji, Zhonghua Ma, Shufen Xu, ZhenYu He, Keming Wang & Jianwei Lu
Pages: 1043-1057
Published online: 05 Feb 2019
AbstractforRETRACTED ARTICLE: Overexpressed long noncoding RNA TUG1 affects the cell cycle, proliferation, and apoptosis of pancreatic cancer partly through suppressing RND3 and MT2A | PDF (2.8 MB)
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Article
Long noncoding RNA GIHCG induces cancer progression and chemoresistance and indicates poor prognosis in colorectal cancer
Xiaohua Jiang, Qin Li, Shun Zhang, Chun Song & Ping Zheng
Pages: 1059-1070
Published online: 07 Feb 2019
AbstractforLong noncoding RNA GIHCG induces cancer progression and chemoresistance and indicates poor prognosis in colorectal cancer | Full Text | References | PDF (2 MB)
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Case Report

Case Report
NCOA1–ALK: a novel ALK rearrangement in one lung adenocarcinoma patient responding to crizotinib treatment
Qi Cao, Zhiguang Liu, Yanhua Huang, Chuang Qi & Xiaowei Yin
Pages: 1071-1074
Published online: 07 Feb 2019
AbstractforNCOA1–ALK: a novel ALK rearrangement in one lung adenocarcinoma patient responding to crizotinib treatment | Full Text | References | PDF (3.6 MB)
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Original Research

Article
CHFR promotes the migration of human gastric cancer cells by inducing epithelial-to-mesenchymal transition in a HDAC1-dependent manner
Shangwen Yang, Feiyun He, Mugen Dai, Jundi Pan, Jianbo Wang & Bin Ye
Pages: 1075-1084
Published online: 07 Feb 2019
AbstractforCHFR promotes the migration of human gastric cancer cells by inducing epithelial-to-mesenchymal transition in a HDAC1-dependent manner | Full Text | References | PDF (4.2 MB)
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Review

Review Article
Mogamulizumab: a new tool for management of cutaneous T-cell lymphoma
Thomas A Ollila, Ilyas Sahin & Adam J Olszewski
Pages: 1085-1094
Published online: 07 Feb 2019
AbstractforMogamulizumab: a new tool for management of cutaneous T-cell lymphoma | Full Text | References | PDF (433.8 KB)
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Review Article
First-line treatment of women with advanced ovarian cancer: focus on bevacizumab
Claudia Marchetti, Ludovico Muzii, Alessia Romito & Pierluigi Benedetti Panici
Pages: 1095-1103
Published online: 08 Feb 2019
AbstractforFirst-line treatment of women with advanced ovarian cancer: focus on bevacizumab | Full Text | References | PDF (214.8 KB)
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Original Research

Article
Expression of Lin28 is correlated with prognosis and expression of HER-2 and steroid receptors in breast cancer
Chaoyang Xu, Shuxun Jin & Liming Huang
Pages: 1105-1110
Published online: 08 Feb 2019
AbstractforExpression of Lin28 is correlated with prognosis and expression of HER-2 and steroid receptors in breast cancer | Full Text | References | PDF (1.5 MB)
  • 27 Views
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Article
Overexpression of shugoshin1 predicts a poor prognosis for prostate cancer and promotes metastasis by affecting epithelial–mesenchymal transition
Jiagui Mu, Li Fan, Duo Liu & Dongsheng Zhu
Pages: 1111-1118
Published online: 08 Feb 2019
AbstractforOverexpression of shugoshin1 predicts a poor prognosis for prostate cancer and promotes metastasis by affecting epithelial–mesenchymal transition | Full Text | References | PDF (2.1 MB)
  • 30 Views
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Article
RETRACTED ARTICLE: Extracellular Hsp90α clinically correlates with tumor malignancy and promotes migration and invasion in esophageal squamous cell carcinoma
Xintong Wang, Dianzheng An, Xinlei Wang, Xiaomeng Liu & Baosheng Li
Pages: 1119-1128
Published online: 11 Feb 2019
AbstractforRETRACTED ARTICLE: Extracellular Hsp90α clinically correlates with tumor malignancy and promotes migration and invasion in esophageal squamous cell carcinoma | PDF (2.1 MB)
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Article
Prognostic implications of MYBL2 in resected Chinese gastric adenocarcinoma patients
Yongxu Jia, Yaping Gao, Jing Li, Zhiwei Chang, Jie Yan & Yanru Qin
Pages: 1129-1135
Published online: 11 Feb 2019
AbstractforPrognostic implications of MYBL2 in resected Chinese gastric adenocarcinoma patients | Full Text | References | PDF (955.5 KB)
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Article
Epstein-Barr virus-encoded LMP1 regulated Pim1 kinase expression promotes nasopharyngeal carcinoma cells proliferation
Ran-ran Ding, Jian-ling Yuan, Ya-nan Jia, Xiao-min Liao, Si-si Wang, Zhong-ming Shao, Mu-yin Feng, Wei Jie & Zhi-hua Shen
Pages: 1137-1146
Published online: 11 Feb 2019
AbstractforEpstein-Barr virus-encoded LMP1 regulated Pim1 kinase expression promotes nasopharyngeal carcinoma cells proliferation | Full Text | References | PDF (2.3 MB)
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Article
RETRACTED ARTICLE: Mst1-Hippo pathway triggers breast cancer apoptosis via inducing mitochondrial fragmentation in a manner dependent on JNK–Drp1 axis
Hui Ouyang, Enxiang Zhou & Huan Wang
Pages: 1147-1159
Published online: 11 Feb 2019
AbstractforRETRACTED ARTICLE: Mst1-Hippo pathway triggers breast cancer apoptosis via inducing mitochondrial fragmentation in a manner dependent on JNK–Drp1 axis | PDF (3.5 MB)
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Article
High-intensity focused ultrasound enhances the effect of bufalin by inducing apoptosis in pancreatic cancer cells
Zhouyu Ning, Zhenfeng Zhu, Haiyong Wang, Chenyue Zhang, Litao Xu, Liping Zhuang, Xia Yan, Dan Wang, Peng Wang & Zhiqiang Meng
Pages: 1161-1170
Published online: 12 Feb 2019
AbstractforHigh-intensity focused ultrasound enhances the effect of bufalin by inducing apoptosis in pancreatic cancer cells | Full Text | References | PDF (2.7 MB)
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Article
Up-regulation of CKAP2L expression promotes lung adenocarcinoma invasion and is associated with poor prognosis
Guosheng Xiong, Liyin Li, Xiaobo Chen, Sinuo Song, Yunping Zhao, Wenke Cai & Jingping Peng
Pages: 1171-1180
Published online: 12 Feb 2019
AbstractforUp-regulation of CKAP2L expression promotes lung adenocarcinoma invasion and is associated with poor prognosis | Full Text | References | PDF (1.9 MB)
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Case Report

Case Report
Rapid and complete response to idelalisib in a case of Richter syndrome
Cristina Bagacean, Mihnea Zdrenghea, Hussam Saad, Christian Berthou, Yves Renaudineau & Adrian Tempescul
Pages: 1181-1184
Published online: 13 Feb 2019
AbstractforRapid and complete response to idelalisib in a case of Richter syndrome | Full Text | References | PDF (479.8 KB)
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Original Research

Article
Dicerandrol B: a natural xanthone dimer induces apoptosis in cervical cancer HeLa cells through the endoplasmic reticulum stress and mitochondrial damage
Dandan Gao, Zhimin Guo, Jiabin Wang, Gaofeng Hu, Yuqiao Su, Lijun Chen, Qianwen Lv, Huimei Yu, Jianchun Qin & Wei Xu
Pages: 1185-1193
Published online: 13 Feb 2019
AbstractforDicerandrol B: a natural xanthone dimer induces apoptosis in cervical cancer HeLa cells through the endoplasmic reticulum stress and mitochondrial damage | Full Text | References | PDF (2.2 MB)
  • 48 Views
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Review

Review Article
Metabolic reprogramming results in abnormal glycolysis in gastric cancer: a review
Yuanda Liu, Ze Zhang, Junyang Wang, Chao Chen, Xiaohuan Tang, Jiaming Zhu & Jingjing Liu
Pages: 1195-1204
Published online: 13 Feb 2019
AbstractforMetabolic reprogramming results in abnormal glycolysis in gastric cancer: a review | Full Text | References | PDF (438.9 KB)
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Article
PNUTS mediates ionizing radiation-induced CNE-2 nasopharyngeal carcinoma cell migration, invasion, and epithelial–mesenchymal transition via the PI3K/AKT signaling pathway
Dan Yu, Xiang An, Wanlin Fan, Xin Wang, Yuxing He & Bing Li
Pages: 1205-1214
Published online: 15 Feb 2019
AbstractforPNUTS mediates ionizing radiation-induced CNE-2 nasopharyngeal carcinoma cell migration, invasion, and epithelial–mesenchymal transition via the PI3K/AKT signaling pathway | Full Text | References | PDF (3.6 MB)
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Article
Combined silencing of VEGF-A and angiopoietin-2, a more effective way to inhibit the Ishikawa endometrial cancer cell line
Xiaofeng Xu, Yuhua Yan, Qingying Xun, Jiayu Shi, Xiangyi Kong, Jun Wu & Huaijun Zhou
Pages: 1215-1223
Published online: 14 Feb 2019
AbstractforCombined silencing of VEGF-A and angiopoietin-2, a more effective way to inhibit the Ishikawa endometrial cancer cell line | Full Text | References | PDF (1.9 MB)
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Article
Knockdown of EIF3C promotes human U-2OS cells apoptosis through increased CASP3/7 and Chk1/2 by upregulating SAPK/JNK
Weilu Gao, Yong Hu, Zhengqin Zhang, Gongwen Du, Li Yin & Zongsheng Yin
Pages: 1225-1235
Published online: 14 Feb 2019
AbstractforKnockdown of EIF3C promotes human U-2OS cells apoptosis through increased CASP3/7 and Chk1/2 by upregulating SAPK/JNK | Full Text | References | PDF (1.7 MB)
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Article
Optimal postoperative adjuvant treatment strategy for HBV-related hepatocellular carcinoma with microvascular invasion: a propensity score analysis
Liming Wang, Bo Chen, Zhuo Li, Xuesong Yao, Mei Liu, Weiqi Rong, Fan Wu, Shengtao Lin, Yunhe Liu, Yiling Zheng, Yexiong Li, Weihu Wang & Jianxiong Wu
Pages: 1237-1247
Published online: 15 Feb 2019
AbstractforOptimal postoperative adjuvant treatment strategy for HBV-related hepatocellular carcinoma with microvascular invasion: a propensity score analysis | Full Text | References | PDF (458.2 KB)
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Article
Upregulation of STC2 in colorectal cancer and its clinicopathological significance
Chunxiao Zhang, Shuangqian Chen, Xiang Ma, Qian Yang, Fei Su, Xiang Shu, Wei Xie, Maohui Feng & Bin Xiong
Pages: 1249-1258
Published online: 15 Feb 2019
AbstractforUpregulation of STC2 in colorectal cancer and its clinicopathological significance | Full Text | References | PDF (3.5 MB)
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Review

Review Article
Moderate hypofractionated radiotherapy vs conventional fractionated radiotherapy in localized prostate cancer: a systemic review and meta-analysis from Phase III randomized trials
Zhenzhen Yin, Jinqiang You, Youyou Wang, Jinlin Zhao, Shengpeng Jiang, Ximei Zhang, Peiguo Wang, Zhen Tao, Xin Wang & Zhiyong Yuan
Pages: 1259-1268
Published online: 15 Feb 2019
AbstractforModerate hypofractionated radiotherapy vs conventional fractionated radiotherapy in localized prostate cancer: a systemic review and meta-analysis from Phase III randomized trials | Full Text | References | PDF (801 KB)
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Original Research

Article
Correlations of lncRNAs with cervical lymph node metastasis and prognosis of papillary thyroid carcinoma
Na Li, Mingming Cui, Ping Yu & Qiang Li
Pages: 1269-1278
Published online: 18 Feb 2019
AbstractforCorrelations of lncRNAs with cervical lymph node metastasis and prognosis of papillary thyroid carcinoma | Full Text | References | PDF (2.4 MB)
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Review

Review Article
Ten years of research on the role of BVES/ POPDC1 in human disease: a review
Ping Han, Yu Lei, Dongxiao Li, Jingmei Liu, Wei Yan & Dean Tian
Pages: 1279-1291
Published online: 18 Feb 2019
AbstractforTen years of research on the role of BVES/ POPDC1 in human disease: a review | Full Text | References | PDF (522.5 KB)
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Original Research

Article
Potent in vitro and xenograft antitumor activity of a novel agent, PV-10, against relapsed and refractory neuroblastoma
Lucy Swift, Chunfen Zhang, Tanya Trippett & Aru Narendran
Pages: 1293-1307
Published online: 18 Feb 2019
AbstractforPotent in vitro and xenograft antitumor activity of a novel agent, PV-10, against relapsed and refractory neuroblastoma | Full Text | References | PDF (3.6 MB)
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Article
High expression of NUCB2 promotes papillary thyroid cancer cells proliferation and invasion
Jingzhu Zhao, Xinwei Yun, Xianhui Ruan, Jiadong Chi, Yang Yu, Yigong Li, Xiangqian Zheng & Ming Gao
Pages: 1309-1318
Published online: 18 Feb 2019
AbstractforHigh expression of NUCB2 promotes papillary thyroid cancer cells proliferation and invasion | Full Text | References | PDF (4.2 MB)
  • 47 Views
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Article
Identification of key pathways and hub genes in basal-like breast cancer using bioinformatics analysis
Kaidi Yang, Jian Gao & Mao Luo
Pages: 1319-1331
Published online: 18 Feb 2019
AbstractforIdentification of key pathways and hub genes in basal-like breast cancer using bioinformatics analysis | Full Text | References | PDF (4 MB)
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Case Report

Case Report
Treatment of adult brainstem glioma with combined antiangiogenic therapy: a case report and literature review
Dongdong Yu, Guang Han, Huali Liu, Likun Gao & Vivek Verma
Pages: 1333-1339
Published online: 18 Feb 2019
AbstractforTreatment of adult brainstem glioma with combined antiangiogenic therapy: a case report and literature review | Full Text | References | PDF (1.7 MB)
  • 59 Views
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Original Research

Article
Irreversible electroporation combined with chemotherapy for unresectable pancreatic carcinoma: a prospective cohort study
Shupeng Liu, Zilin Qin, Jiongyuan Xu, Jianying Zeng, Jibing Chen, Lizhi Niu & Meng Xu
Pages: 1341-1350
Published online: 18 Feb 2019
AbstractforIrreversible electroporation combined with chemotherapy for unresectable pancreatic carcinoma: a prospective cohort study | Full Text | References | PDF (1.4 MB)
  • 43 Views
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Article
lncRNA SLCO4A1-AS1 promotes growth and invasion of bladder cancer through sponging miR-335-5p to upregulate OCT4
Yu Yang, Feng Wang, Hang Huang, Yan Zhang, Hui Xie & Tongyi Men
Pages: 1351-1358
Published online: 18 Feb 2019
AbstractforlncRNA SLCO4A1-AS1 promotes growth and invasion of bladder cancer through sponging miR-335-5p to upregulate OCT4 | Full Text | References | PDF (1.5 MB)
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Case Report

Case Report
Stereotactic body radiation therapy for pulmonary large cell neuroendocrine carcinoma: a case report
In Young Jo & Seung-Gu Yeo
Pages: 1359-1364
Published online: 18 Feb 2019
AbstractforStereotactic body radiation therapy for pulmonary large cell neuroendocrine carcinoma: a case report | Full Text | References | PDF (1.5 MB)
  • 36 Views
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Original Research

Article
lncRNA MALAT1 potentiates the progression of tongue squamous cell carcinoma through regulating miR-140-5p-PAK1 pathway
Minhui Zhu, Caiyun Zhang, Donghui Chen, Shicai Chen & Hongliang Zheng
Pages: 1365-1377
Published online: 19 Feb 2019
AbstractforlncRNA MALAT1 potentiates the progression of tongue squamous cell carcinoma through regulating miR-140-5p-PAK1 pathway | Full Text | References | PDF (2.1 MB)
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Article
CT-guided cryoablation for unresectable pelvic recurrent colorectal cancer: a retrospective study
Ying Wang, Xin-Hong He, Li-Chao Xu, Hao-Zhe Huang, Guo-Dong Li, Yao-Hui Wang, Wen-Tao Li & Guang-Zhi Wang
Pages: 1379-1387
Published online: 19 Feb 2019
AbstractforCT-guided cryoablation for unresectable pelvic recurrent colorectal cancer: a retrospective study | Full Text | References | PDF (2.1 MB)
  • 53 Views
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Case Series

Brain metastases from breast cancer may respond to endocrine therapy: report of two cases
Qian Wang, Bing Sun, Chao Liu, Sanzhong Shi, Lijuan Ding, Jiannan Liu & Shikai Wu
Pages: 1389-1393
Published online: 19 Feb 2019
AbstractforBrain metastases from breast cancer may respond to endocrine therapy: report of two cases | Full Text | References | PDF (1 MB)
  • 36 Views
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Case Report

Case Report
Merkel cell carcinoma metastatic to cervical lymph node in a patient with rheumatoid arthritis: a case report
Na Li, Guodong Wang, Xiaohong Jiang, Minguang Huang, Huanyong Tian, Feng Xuan, Yufeng Zhang, Yanting Lv, Mengjun Hu, Zhen Wang, Peng Ren & Maoyi Xu
Pages: 1395-1400
Published online: 19 Feb 2019
AbstractforMerkel cell carcinoma metastatic to cervical lymph node in a patient with rheumatoid arthritis: a case report | Full Text | References | PDF (2.4 MB)
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Original Research

Article
Bioinformatic analysis of miR-4792 regulates Radix Tetrastigma hemsleyani flavone to inhibit proliferation, invasion, and induce apoptosis of A549 cells
Peigang Liu, Jinbao Pu, Junhui Zhang, Zhilu Chen, Kemin Wei & Lian’gen Shi
Pages: 1401-1412
Published online: 20 Feb 2019
AbstractforBioinformatic analysis of miR-4792 regulates Radix Tetrastigma hemsleyani flavone to inhibit proliferation, invasion, and induce apoptosis of A549 cells | Full Text | References | PDF (2.4 MB)
  • 38 Views
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Review

Review Article
First-line tyrosine kinase inhibitors in EGFR mutation-positive non-small-cell lung cancer: a network meta-analysis
Marscha S Holleman, Harm van Tinteren, Harry JM Groen, Maiwenn J Al & Carin A Uyl-de Groot
Pages: 1413-1421
Published online: 20 Feb 2019
AbstractforFirst-line tyrosine kinase inhibitors in EGFR mutation-positive non-small-cell lung cancer: a network meta-analysis | Full Text | References | PDF (390.5 KB)
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Original Research

Article
Extracellular matrix protein 1 (ECM1) is associated with carcinogenesis potential of human bladder cancer
Zhicai Wang, Qun Zhou, Aolin Li, Weiren Huang, Zhiming Cai & Wei Chen
Pages: 1423-1432
Published online: 20 Feb 2019
AbstractforExtracellular matrix protein 1 (ECM1) is associated with carcinogenesis potential of human bladder cancer | Full Text | References | PDF (2.2 MB)
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Case Report

Case Report
Multiple extramedullary plasmacytomas of the trachea and pharyngeal tissue: a case report and literature review
Ru-rong Tang, Yan Wang, Chao-nan Liang, Wei Li, Ling Pei, Jian Kang & Gang Hou
Pages: 1433-1437
Published online: 20 Feb 2019
AbstractforMultiple extramedullary plasmacytomas of the trachea and pharyngeal tissue: a case report and literature review | Full Text | References | PDF (2.4 MB)
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Original Research

Article
Impact of liver kinase B1 on p53 and survivin and its correlation with prognosis in gastric cancer
Weiwei Li, Shunxiang Luo, Guowei Ma & Lin Wang
Pages: 1439-1445
Published online: 22 Feb 2019
AbstractforImpact of liver kinase B1 on p53 and survivin and its correlation with prognosis in gastric cancer | Full Text | References | PDF (1.9 MB)
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Article
IL-27 inhibits non-small-cell lung cancer cell metastasis by miR-935 in vitro
Tao Wang, Yifei Chen, Hanxiang Nie, Yi Huang, Yang Zhao & Jiong Yang
Pages: 1447-1454
Published online: 21 Feb 2019
AbstractforIL-27 inhibits non-small-cell lung cancer cell metastasis by miR-935 in vitro | Full Text | References | PDF (905.2 KB)
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Review

Review Article
Spotlight on liposomal irinotecan for metastatic pancreatic cancer: patient selection and perspectives
Wonhee Woo, Edward T Carey & Minsig Choi
Pages: 1455-1463
Published online: 21 Feb 2019
AbstractforSpotlight on liposomal irinotecan for metastatic pancreatic cancer: patient selection and perspectives | Full Text | References | PDF (218.3 KB)
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Original Research

Article
BRAF mutation in cytologically indeterminate thyroid nodules: after reclassification of a variant thyroid carcinoma
Warut Pongsapich, Cheerasook Chongkolwatana, Naravat Poungvarin, Kanchana Amornpichetkul, Nutthaya Piyawattayakorn, Pichpisith Vejvisithsakul & Prachya Maneeprasopchoke
Pages: 1465-1473
Published online: 21 Feb 2019
AbstractforBRAF mutation in cytologically indeterminate thyroid nodules: after reclassification of a variant thyroid carcinoma | Full Text | References | PDF (3.5 MB)
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Article
Sympathetic innervation contributes to perineural invasion of salivary adenoid cystic carcinoma via the β2-adrenergic receptor
Chao Ma, Tao Gao, Jun Ju, Yi Zhang, Qianwei Ni, Yun Li, Zhenyan Zhao, Juan Chai, Xiangming Yang & Moyi Sun
Pages: 1475-1495
Published online: 21 Feb 2019
AbstractforSympathetic innervation contributes to perineural invasion of salivary adenoid cystic carcinoma via the β2-adrenergic receptor | Full Text | References | PDF (15.5 MB)
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Review

Review Article
The surgical perspective in precision treatment of diffuse gliomas
Niklas Thon, Joerg-Christian Tonn & Friedrich-Wilhelm Kreth
Pages: 1497-1508
Published online: 22 Feb 2019
AbstractforThe surgical perspective in precision treatment of diffuse gliomas | Full Text | References | PDF (2.2 MB)
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Original Research

Article
Downregulation of KLF13 through DNMT1-mediated hypermethylation promotes glioma cell proliferation and invasion
Rile Wu, Qiang Yun, Jianping Zhang & Jingang Bao
Pages: 1509-1520
Published online: 22 Feb 2019
AbstractforDownregulation of KLF13 through DNMT1-mediated hypermethylation promotes glioma cell proliferation and invasion | Full Text | References | PDF (2.4 MB)
  • 34 Views
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Review

Review Article
Development of treatment options for Chinese patients with advanced squamous cell lung cancer: focus on afatinib
Shun Lu
Pages: 1521-1538
Published online: 22 Feb 2019
AbstractforDevelopment of treatment options for Chinese patients with advanced squamous cell lung cancer: focus on afatinib | Full Text | References | PDF (3.8 MB)
  • 30 Views
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Review Article
Caveolin-1: a multifaceted driver of breast cancer progression and its application in clinical treatment
Xian-Ling Qian, Yi-Hang Pan, Qi-Yuan Huang, Yu-Bo Shi, Qing-Yun Huang, Zhen-Zhen Hu & Li-Xia Xiong
Pages: 1539-1552
Published online: 27 Feb 2019
AbstractforCaveolin-1: a multifaceted driver of breast cancer progression and its application in clinical treatment | Full Text | References | PDF (1.1 MB)
  • 95 Views
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Original Research

Article
NACT+IMRT versus NACT+IMRT+CCRT in locoregionally advanced NPC patients: a retrospective study
Xialin Chen, Xiang Zhu, Jianfang Wang, Jianjiang Liu & Rong Ji
Pages: 1553-1562
Published online: 22 Feb 2019
AbstractforNACT+IMRT versus NACT+IMRT+CCRT in locoregionally advanced NPC patients: a retrospective study | Full Text | References | PDF (389.9 KB)
  • 30 Views
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Article
Deleted in breast cancer 1 as a potential prognostic biomarker in human cancers: a pooled analysis of 2,254 patients
Gang Liu, Qiaosheng Wu, Yili Wang, Qiuyun Xiong & Feiguo Fu
Pages: 1563-1574
Published online: 22 Feb 2019
AbstractforDeleted in breast cancer 1 as a potential prognostic biomarker in human cancers: a pooled analysis of 2,254 patients | Full Text | References | PDF (575 KB)
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Article
MLL3 promotes the senescence of esophageal squamous cell carcinoma
Manhui Xia, Feng Ling, Feng Gao & Chunmu Tao
Pages: 1575-1582
Published online: 01 Mar 2019
AbstractforMLL3 promotes the senescence of esophageal squamous cell carcinoma | Full Text | References | PDF (4.3 MB)
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Review

Review Article
Management of recurrent nasopharyngeal carcinoma: current perspectives
F Perri, G Della Vittoria Scarpati, F Caponigro, F Ionna, F Longo, S Buonopane, P Muto, M Di Marzo, S Pisconti & R Solla
Pages: 1583-1591
Published online: 26 Feb 2019
AbstractforManagement of recurrent nasopharyngeal carcinoma: current perspectives | Full Text | References | PDF (224.1 KB)
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Case Report

Case Report
Primary poorly differentiated small cell type neuroendocrine carcinoma of the hypopharynx
Yin-Jie Ao & Shui-Hong Zhou
Pages: 1593-1601
Published online: 27 Feb 2019
AbstractforPrimary poorly differentiated small cell type neuroendocrine carcinoma of the hypopharynx | Full Text | References | PDF (3.1 MB)
  • 43 Views
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Original Research

Article
Ubiquitin-specific peptidase 28 enhances STAT3 signaling and promotes cell growth in non-small-cell lung cancer
Pengling Li, Ziming Huang, Jipeng Wang, Wei Chen & Jianan Huang
Pages: 1603-1611
Published online: 26 Feb 2019
AbstractforUbiquitin-specific peptidase 28 enhances STAT3 signaling and promotes cell growth in non-small-cell lung cancer | Full Text | References | PDF (1.5 MB)
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Article
The accumulation of metabolic syndrome components is associated with higher risk of positive surgical margin among patients with localized prostate cancer after radical prostatectomy
Xiaonan Zheng, Shi Qiu, Xinyang Liao, Xin Han, Kun Jin, Lu Yang & Qiang Wei
Pages: 1613-1620
Published online: 26 Feb 2019
AbstractforThe accumulation of metabolic syndrome components is associated with higher risk of positive surgical margin among patients with localized prostate cancer after radical prostatectomy | Full Text | References | PDF (507.9 KB)
  • 26 Views
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Article
Nab-paclitaxel in pretreated metastatic breast cancer: evaluation of activity, safety, and quality of life
Rossella De Luca, Giuseppe Profita & Giuseppe Cicero
Pages: 1621-1627
Published online: 26 Feb 2019
AbstractforNab-paclitaxel in pretreated metastatic breast cancer: evaluation of activity, safety, and quality of life | Full Text | References | PDF (313.6 KB)
  • 61 Views
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Article
ARQ-197 enhances the antitumor effect of sorafenib in hepatocellular carcinoma cells via decelerating its intracellular clearance
Xudong Gao, Hebing Chen, Xin Huang, Hao Li, Zhen Liu & Xiaochen Bo
Pages: 1629-1640
Published online: 26 Feb 2019
AbstractforARQ-197 enhances the antitumor effect of sorafenib in hepatocellular carcinoma cells via decelerating its intracellular clearance | Full Text | References | PDF (1.3 MB)
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Article
TCTP promotes epithelial–mesenchymal transition in lung adenocarcinoma
Ruilin Sun, Xi Lu, Li Gong & Faguang Jin
Pages: 1641-1653
Published online: 27 Feb 2019
AbstractforTCTP promotes epithelial–mesenchymal transition in lung adenocarcinoma | Full Text | References | PDF (4.5 MB)
  • 40 Views
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Article
The contribution of ABCG2 G34A and C421A polymorphisms to multiple myeloma susceptibility
Katarzyna Niebudek, Ewa Balcerczak, Marek Mirowski, Jacek Pietrzak, Izabela Zawadzka & Marta Żebrowska-Nawrocka
Pages: 1655-1660
Published online: 27 Feb 2019
AbstractforThe contribution of ABCG2 G34A and C421A polymorphisms to multiple myeloma susceptibility | Full Text | References | PDF (199.1 KB)
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Article
Clinical utility of a novel natural killer cell activity assay for diagnosing non-small cell lung cancer: a prospective pilot study
Sue In Choi, Seung Hyeun Lee, Ji-Young Park, Kyoung-Ah Kim, Eun Joo Lee, Sang Yeub Lee & Kwang Ho In
Pages: 1661-1669
Published online: 27 Feb 2019
AbstractforClinical utility of a novel natural killer cell activity assay for diagnosing non-small cell lung cancer: a prospective pilot study | Full Text | References | PDF (772.7 KB)
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Article
Effects of various interventions on the occurrence of macrovascular invasion of hepatocellular carcinoma after the baseline serum γ-glutamyltransferase stratification
Yao Liu, Qun Zhang, Xue Yang, Yuxin Li, Bingbing Zhu, Shuaishuai Niu, Yunyi Huang, Ying Hu & Xianbo Wang
Pages: 1671-1679
Published online: 28 Feb 2019
AbstractforEffects of various interventions on the occurrence of macrovascular invasion of hepatocellular carcinoma after the baseline serum γ-glutamyltransferase stratification | Full Text | References | PDF (689.6 KB)
  • 39 Views
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Article
Concurrent apatinib and docetaxel vs apatinib monotherapy as third- or subsequent-line therapy for advanced gastric adenocarcinoma: a retrospective study
Haimin Lin, Dali Han, Guobin Fu, Chengxin Liu, Lili Wang, Shumei Han, Bo Liu & Jinming Yu
Pages: 1681-1689
Published online: 28 Feb 2019
AbstractforConcurrent apatinib and docetaxel vs apatinib monotherapy as third- or subsequent-line therapy for advanced gastric adenocarcinoma: a retrospective study | Full Text | References | PDF (445.2 KB)
  • 30 Views
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Article
RRAD suppresses the Warburg effect by downregulating ACTG1 in hepatocellular carcinoma
Yingcai Yan, Hao Xu, Linshi Zhang, Xiaohu Zhou, Xiaohui Qian, Jiarong Zhou, Yu Huang, Wenhao Ge & Weilin Wang
Pages: 1691-1703
Published online: 28 Feb 2019
AbstractforRRAD suppresses the Warburg effect by downregulating ACTG1 in hepatocellular carcinoma | Full Text | References | PDF (9.3 MB)
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Article
CD24 isoform a promotes cell proliferation, migration and invasion and is downregulated by EGR1 in hepatocellular carcinoma
Liangyu Li, Jing Chen, Chao Ge, Fangyu Zhao, Taoyang Chen, Hua Tian, Jinjun Li & Hong Li
Pages: 1705-1716
Published online: 28 Feb 2019
AbstractforCD24 isoform a promotes cell proliferation, migration and invasion and is downregulated by EGR1 in hepatocellular carcinoma | Full Text | References | PDF (2.7 MB)
  • 35 Views
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Article
Everolimus for the treatment of advanced gastrointestinal or lung nonfunctional neuroendocrine tumors in East Asian patients: a subgroup analysis of the RADIANT-4 study
James C Yao, Do-Youn Oh, Jiaming Qian, Young Suk Park, Fabian Herbst, Antonia Ridolfi, Miguel Izquierdo, Tetsuhide Ito, Liqun Jia, Izumi Komoto, Virote Sriuranpong & Yasuhiro Shimada
Pages: 1717-1728
Published online: 28 Feb 2019
AbstractforEverolimus for the treatment of advanced gastrointestinal or lung nonfunctional neuroendocrine tumors in East Asian patients: a subgroup analysis of the RADIANT-4 study | Full Text | References | PDF (506.9 KB)
  • 51 Views
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Article
Dichloroacetic acid upregulates apoptosis of ovarian cancer cells by regulating mitochondrial function
Li Zhou, Lianlian Liu, Wei Chai, Ting Zhao, Xin Jin, Xinxin Guo, Liying Han & Chunli Yuan
Pages: 1729-1739
Published online: 28 Feb 2019
AbstractforDichloroacetic acid upregulates apoptosis of ovarian cancer cells by regulating mitochondrial function | Full Text | References | PDF (1.9 MB)
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Article
Single institution experience of split course radiotherapy in patients with desmoid tumors
Jurui Luo, Kairui Jin, Shuizhang Qian, Xuejun Ma, Ziqiang Pan, Weiqiang Yao, Zhen Zhang, Xiaomao Guo & Xiaoli Yu
Pages: 1741-1748
Published online: 07 Mar 2019
AbstractforSingle institution experience of split course radiotherapy in patients with desmoid tumors | Full Text | References | PDF (317.3 KB)
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Article
Upregulated expression of ACTL8 contributes to invasion and metastasis and indicates poor prognosis in colorectal cancer
Qiang Han, Ming-Li Sun, Wen-Si Liu, Hai-Shan Zhao, Long-Yang Jiang, Zhao-Jin Yu & Min-Jie Wei
Pages: 1749-1763
Published online: 01 Mar 2019
AbstractforUpregulated expression of ACTL8 contributes to invasion and metastasis and indicates poor prognosis in colorectal cancer | Full Text | References | PDF (4.7 MB)
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Article
Genetic ablation of TAZ induces HepG2 liver cancer cell apoptosis through activating the CaMKII/MIEF1 signaling pathway
Yi Hou, Chunna Lan, Ying Kong, Chunjiao Zhu, Wenna Peng, Zhichao Huang & Changjie Zhang
Pages: 1765-1779
Published online: 01 Mar 2019
AbstractforGenetic ablation of TAZ induces HepG2 liver cancer cell apoptosis through activating the CaMKII/MIEF1 signaling pathway | Full Text | References | PDF (4.2 MB)
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Review

Review Article
Targeting Trop-2 in solid tumors: future prospects
Saif Zaman, Hassan Jadid, Aaron C Denson & Jhanelle E Gray
Pages: 1781-1790
Published online: 01 Mar 2019
AbstractforTargeting Trop-2 in solid tumors: future prospects | Full Text | References | PDF (218.1 KB)
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Original Research

Article
A meta-analysis of the efficacy and safety of PD-1/PD-L1 immune checkpoint inhibitors as treatments for metastatic bladder cancer
Zhongyuan Fan, Ye Liang, Xuecheng Yang, Bin Li, Lili Cui, Lei Luo, Yuefeng Jia, Yonghua Wang & Haitao Niu
Pages: 1791-1801
Published online: 04 Mar 2019
AbstractforA meta-analysis of the efficacy and safety of PD-1/PD-L1 immune checkpoint inhibitors as treatments for metastatic bladder cancer | Full Text | References | PDF (1,023.1 KB)
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Article
Elevated HOXA13 expression promotes the proliferation and metastasis of gastric cancer partly via activating Erk1/2
Zhiwei Qin, Zhengqian Chen, Junyong Weng, Shanbao Li, Zeyin Rong & Chongzhi Zhou
Pages: 1803-1813
Published online: 04 Mar 2019
AbstractforElevated HOXA13 expression promotes the proliferation and metastasis of gastric cancer partly via activating Erk1/2 | Full Text | References | PDF (10.1 MB)
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Article
The overexpression of Rab9 promotes tumor progression regulated by XBP1 in breast cancer
Yansong Liu, Xin Wang, Zhonghua Zhang, Bin Xiao, Baoming An & Jun Zhang
Pages: 1815-1824
Published online: 04 Mar 2019
AbstractforThe overexpression of Rab9 promotes tumor progression regulated by XBP1 in breast cancer | Full Text | References | PDF (2.1 MB)
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Article
Ubiquitin-specific protease 4 promotes glioblastoma multiforme via activating ERK pathway
Yudong Zhou, Ping Liang, Wenyuan Ji, Zengpeng Yu, Hui Chen & Li Jiang
Pages: 1825-1839
Published online: 05 Mar 2019
AbstractforUbiquitin-specific protease 4 promotes glioblastoma multiforme via activating ERK pathway | Full Text | References | PDF (6.6 MB)
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Article
Lipid nanobubbles as an ultrasound-triggered artesunate delivery system for imaging-guided, tumor-targeted chemotherapy
Shuang Gao, Xiaohui Cheng & Jinhua Li
Pages: 1841-1850
Published online: 06 Mar 2019
AbstractforLipid nanobubbles as an ultrasound-triggered artesunate delivery system for imaging-guided, tumor-targeted chemotherapy | Full Text | References | PDF (1.9 MB)
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Case Report

Case Report
A case report for severe hand-foot skin reaction caused by chemotherapy with actinomycin D in a patient with oculocutaneous albinism
Shi-Jie Yan, Yan Li, Ze-Lian Li, Ying Chen, Xiao-Hui Zhang & Lan Xiao
Pages: 1851-1855
Published online: 08 Mar 2019
AbstractforA case report for severe hand-foot skin reaction caused by chemotherapy with actinomycin D in a patient with oculocutaneous albinism | Full Text | References | PDF (1.2 MB)
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Review

Review Article
Targeting off-target effects: endoplasmic reticulum stress and autophagy as effective strategies to enhance temozolomide treatment
Yichun He, Jing Su, Beiwu Lan, Yufei Gao & Jingxia Zhao
Pages: 1857-1865
Published online: 07 Mar 2019
AbstractforTargeting off-target effects: endoplasmic reticulum stress and autophagy as effective strategies to enhance temozolomide treatment | Full Text | References | PDF (597 KB)
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Original Research

Article
ROS generation and autophagosome accumulation contribute to the DMAMCL-induced inhibition of glioma cell proliferation by regulating the ROS/MAPK signaling pathway and suppressing the Akt/mTOR signaling pathway
Yanjun Wang, Jiachen Zhang, Yihang Yang, Qian Liu, Guangming Xu, Rui Zhang & Qi Pang
Pages: 1867-1880
Published online: 07 Mar 2019
AbstractforROS generation and autophagosome accumulation contribute to the DMAMCL-induced inhibition of glioma cell proliferation by regulating the ROS/MAPK signaling pathway and suppressing the Akt/mTOR signaling pathway | Full Text | References | PDF (8.2 MB)
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Article
Neoadjuvant chemotherapy with radical surgery vs radical surgery alone for cervical cancer: a systematic review and meta-analysis
Hui Zhao, Yue He, Shu-Li Yang, Qun Zhao & Yu-Mei Wu
Pages: 1881-1891
Published online: 07 Mar 2019
AbstractforNeoadjuvant chemotherapy with radical surgery vs radical surgery alone for cervical cancer: a systematic review and meta-analysis | Full Text | References | PDF (1.1 MB)
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Article
RETRACTED ARTICLE: MACC1 promotes angiogenesis in cholangiocarcinoma by upregulating VEGFA
Tao Peng, Zhonghu Li, Dajiang Li & Shuguang Wang
Pages: 1893-1903
Published online: 08 Mar 2019
AbstractforRETRACTED ARTICLE: MACC1 promotes angiogenesis in cholangiocarcinoma by upregulating VEGFA | PDF (3 MB)
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Review

Review Article
lncRNAs as potential molecular biomarkers in the clinicopathology and prognosis of cholangiocarcinoma: a systematic review and meta-analysis
Kangfu Dai, Jing Quan, Fangli Yan, Xinghan Jin, Xiang Pan, Xiaorui Song, Shijie Zhang, Qingqi Ren, Jikui Liu & Xiaoping Liu
Pages: 1905-1915
Published online: 08 Mar 2019
AbstractforlncRNAs as potential molecular biomarkers in the clinicopathology and prognosis of cholangiocarcinoma: a systematic review and meta-analysis | Full Text | References | PDF (926.3 KB)
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Original Research

Article
Prognostic implications and oncogenic roles of MYBL2 protein expression in esophageal squamous-cell carcinoma
Hui Qin, Yunyun Li, Hongyan Zhang, Feng Wang, Hongliu He, Xue Bai & Shanshan Li
Pages: 1917-1927
Published online: 08 Mar 2019
AbstractforPrognostic implications and oncogenic roles of MYBL2 protein expression in esophageal squamous-cell carcinoma | Full Text | References | PDF (9.6 MB)
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Article
Long noncoding RNA STXBP5-AS1 inhibits cell proliferation, migration, and invasion through inhibiting the PI3K/AKT signaling pathway in gastric cancer cells
Dongzhi Cen, Hu Huang, Liu Yang, Kai Guo & Jinshan Zhang
Pages: 1929-1936
Published online: 08 Mar 2019
AbstractforLong noncoding RNA STXBP5-AS1 inhibits cell proliferation, migration, and invasion through inhibiting the PI3K/AKT signaling pathway in gastric cancer cells | Full Text | References | PDF (2.7 MB)
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Review

Review Article
Mechanisms of drug resistance in acute myeloid leukemia
Jing Zhang, Yan Gu & Baoan Chen
Pages: 1937-1945
Published online: 11 Mar 2019
AbstractforMechanisms of drug resistance in acute myeloid leukemia | Full Text | References | PDF (269.1 KB)
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Original Research

Article
Hypoxic non-small-cell lung cancer cell-derived exosomal miR-21 promotes resistance of normoxic cell to cisplatin
Caijun Dong, Xingwang Liu, Huisheng Wang, Jutao Li, Lei Dai, Jun Li & Zhen Xu
Pages: 1947-1956
Published online: 12 Mar 2019
AbstractforHypoxic non-small-cell lung cancer cell-derived exosomal miR-21 promotes resistance of normoxic cell to cisplatin | Full Text | References | PDF (2.9 MB)
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Article
Elevated apolipoprotein B predicts poor postsurgery prognosis in patients with hepatocellular carcinoma
Xiaotong Yan, Mingjie Yao, Xiajie Wen, Yiwei Zhu, Erjiang Zhao, Xiangjun Qian, Xiangmei Chen, Weiquan Lu, Quanjun Lv, Ling Zhang & Fengmin Lu
Pages: 1957-1964
Published online: 12 Mar 2019
AbstractforElevated apolipoprotein B predicts poor postsurgery prognosis in patients with hepatocellular carcinoma | Full Text | References | PDF (894.9 KB)
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Article
Downregulation of MMSET impairs breast cancer proliferation and metastasis through inhibiting Wnt/β-catenin signaling
Xiaohui Zhao, Tian Xie, Wenhui Zhao, Wanhua Cai & Xiaobo Su
Pages: 1965-1977
Published online: 14 Mar 2019
AbstractforDownregulation of MMSET impairs breast cancer proliferation and metastasis through inhibiting Wnt/β-catenin signaling | Full Text | References | PDF (5.9 MB)
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Article
Construction of prognostic microRNA signature for human invasive breast cancer by integrated analysis
Wei Shi, Fang Dong, Yujia Jiang, Linlin Lu, Changwen Wang, Jie Tan, Wen Yang, Hui Guo, Jie Ming & Tao Huang
Pages: 1979-2010
Published online: 15 Mar 2019
AbstractforConstruction of prognostic microRNA signature for human invasive breast cancer by integrated analysis | Full Text | References | PDF (2.1 MB)
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Article
Curcumin inhibits the proliferation and invasion of MG-63 cells through inactivation of the p-JAK2/p-STAT3 pathway
Yuanjue Sun, Liguo Liu, Yaling Wang, Aina He, Haiyan Hu, Jianjun Zhang, Mingyong Han & Yujing Huang
Pages: 2011-2021
Published online: 15 Mar 2019
AbstractforCurcumin inhibits the proliferation and invasion of MG-63 cells through inactivation of the p-JAK2/p-STAT3 pathway | Full Text | References | PDF (4.3 MB)
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Article
Microcalcification and BMP-2 in breast cancer: correlation with clinicopathological features and outcomes
Li Zhang, Chunfang Hao, Yansheng Wu, Yuying Zhu, Yulin Ren & Zhongsheng Tong
Pages: 2023-2033
Published online: 15 Mar 2019
AbstractforMicrocalcification and BMP-2 in breast cancer: correlation with clinicopathological features and outcomes | Full Text | References | PDF (1.5 MB)
  • 51 Views
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Article
Paradoxical effects of cellular senescence-inhibited gene involved in hepatocellular carcinoma migration and proliferation by ERK pathway and mesenchymal-like markers
Qian Cheng, Tan-jun Tong, Zhao Li, Shi-hua Hu, Ding-bao Chen, Si-qi Wang & Ji-ye Zhu
Pages: 2035-2046
Published online: 15 Mar 2019
AbstractforParadoxical effects of cellular senescence-inhibited gene involved in hepatocellular carcinoma migration and proliferation by ERK pathway and mesenchymal-like markers | Full Text | References | PDF (3.3 MB)
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Review

Review Article
Spotlight on aldoxorubicin (INNO-206) and its potential in the treatment of soft tissue sarcomas: evidence to date
Lee D Cranmer
Pages: 2047-2062
Published online: 18 Mar 2019
AbstractforSpotlight on aldoxorubicin (INNO-206) and its potential in the treatment of soft tissue sarcomas: evidence to date | Full Text | References | PDF (368.1 KB)
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Original Research

Article
Elevated expression of microRNA-328-3p suppresses aggressive malignant behaviors via targeting matrix metalloprotease 16 in osteosarcoma
Ming Zhang, Jiayuan Zhang & Quan Zhou
Pages: 2063-2070
Published online: 18 Mar 2019
AbstractforElevated expression of microRNA-328-3p suppresses aggressive malignant behaviors via targeting matrix metalloprotease 16 in osteosarcoma | Full Text | References | PDF (1.3 MB)
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Article
Effect of 21-gene recurrence score in decision-making for surgery in early stage breast cancer
San-Gang Wu, Wen-Wen Zhang, Jun Wang, Yong Dong, Yong-Xiong Chen & Zhen-Yu He
Pages: 2071-2078
Published online: 19 Mar 2019
AbstractforEffect of 21-gene recurrence score in decision-making for surgery in early stage breast cancer | Full Text | References | PDF (561.1 KB)
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Article
Anti-PD1 up-regulates PD-L1 expression and inhibits T-cell lymphoma progression: possible involvement of an IFN-γ-associated JAK-STAT pathway
Weili Xue, Weiming Li, Tiantian Zhang, Zhaoming Li, Yingjun Wang, Yajuan Qiu, Yuanyuan Wang, Changying Chen, Dongjun Fu & Mingzhi Zhang
Pages: 2079-2088
Published online: 19 Mar 2019
AbstractforAnti-PD1 up-regulates PD-L1 expression and inhibits T-cell lymphoma progression: possible involvement of an IFN-γ-associated JAK-STAT pathway | Full Text | References | PDF (1.6 MB)
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Case Series

Two cases of lymphangitic carcinomatosis as the primary symptom of colorectal carcinoma that achieved complete remission using combination anti-EGFR antibody therapy
Hirokazu Toshima, Toshikazu Ikusue, Atsushi Hisamatsu, Kouji Kobayashi & Ken Shimada
Pages: 2089-2093
Published online: 20 Mar 2019
AbstractforTwo cases of lymphangitic carcinomatosis as the primary symptom of colorectal carcinoma that achieved complete remission using combination anti-EGFR antibody therapy | Full Text | References | PDF (12.1 MB)
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Original Research

Article
Nonhomologous end joining key factor XLF enhances both 5-florouracil and oxaliplatin resistance in colorectal cancer
Zhuo Liu, Miao Yu, Bingyuan Fei, Jing Sun & Dongxin Wang
Pages: 2095-2104
Published online: 20 Mar 2019
AbstractforNonhomologous end joining key factor XLF enhances both 5-florouracil and oxaliplatin resistance in colorectal cancer | Full Text | References | PDF (1.4 MB)
  • 33 Views
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Article
Elevated nuclear auto-antigenic sperm protein promotes melanoma progression by inducing cell proliferation
Jia-Xia Li, Chuan-Yuan Wei, Shu-Gang Cao & Ming-Wu Xia
Pages: 2105-2113
Published online: 21 Mar 2019
AbstractforElevated nuclear auto-antigenic sperm protein promotes melanoma progression by inducing cell proliferation | Full Text | References | PDF (1.6 MB)
  • 41 Views
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Article
SUVmax and metabolic tumor volume: surrogate image biomarkers of KRAS mutation status in colorectal cancer
Ying Lv, Xin Wang, Lerong Liang, Lei Wang & Jie Lu
Pages: 2115-2121
Published online: 21 Mar 2019
AbstractforSUVmax and metabolic tumor volume: surrogate image biomarkers of KRAS mutation status in colorectal cancer | Full Text | References | PDF (406.7 KB)
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Review

Review Article
Research status and progress of the RNA or protein biomarkers for prostate cancer
Chunjiao Song, Huan Chen & Chunyu Song
Pages: 2123-2136
Published online: 22 Mar 2019
AbstractforResearch status and progress of the RNA or protein biomarkers for prostate cancer | Full Text | References | PDF (286 KB)
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Original Research

Article
CDK7 inhibitor suppresses tumor progression through blocking the cell cycle at the G2/M phase and inhibiting transcriptional activity in cervical cancer
Shanshan Zhong, Yi Zhang, Xia Yin & Wen Di
Pages: 2137-2147
Published online: 22 Mar 2019
AbstractforCDK7 inhibitor suppresses tumor progression through blocking the cell cycle at the G2/M phase and inhibiting transcriptional activity in cervical cancer | Full Text | References | PDF (4.1 MB)
  • 76 Views
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Article
miR-1-3p suppresses proliferation of hepatocellular carcinoma through targeting SOX9
Hao Zhang, Zhenya Zhang, Lili Gao, Zhengdong Qiao, Minghua Yu, Bo Yu & Tao Yang
Pages: 2149-2157
Published online: 22 Mar 2019
AbstractformiR-1-3p suppresses proliferation of hepatocellular carcinoma through targeting SOX9 | Full Text | References | PDF (942.6 KB)
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Article
Weekly alternate intensive regimen FIrB/FOx in metastatic colorectal cancer patients: an update from clinical practice
Alessio Cortellini, Katia Cannita, Alessandro Parisi, Paola Lanfiuti Baldi, Olga Venditti, Carla D’Orazio, Antonella Dal Mas, Giuseppe Calvisi, Aldo V Giordano, Vincenzo Vicentini, Roberto Vicentini, Lara Felicioni, Antonio Marchetti, Fiamma Buttitta, Antonio Russo & Corrado Ficorella
Pages: 2159-2170
Published online: 25 Mar 2019
AbstractforWeekly alternate intensive regimen FIrB/FOx in metastatic colorectal cancer patients: an update from clinical practice | Full Text | References | PDF (795.1 KB)
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Article
The role of IRAK1 in breast cancer patients treated with neoadjuvant chemotherapy
Muwen Yang, Xingsong Qin, Guangyuan Qin & Xinyu Zheng
Pages: 2171-2180
Published online: 25 Mar 2019
AbstractforThe role of IRAK1 in breast cancer patients treated with neoadjuvant chemotherapy | Full Text | References | PDF (6.4 MB)
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Case Report

Case Report
A case of small-cell lung cancer with adrenocorticotropic hormone deficiency induced by nivolumab
Yan Zhu, Hong Hua Wu & Wei Wang
Pages: 2181-2186
Published online: 25 Mar 2019
AbstractforA case of small-cell lung cancer with adrenocorticotropic hormone deficiency induced by nivolumab | Full Text | References | PDF (855.3 KB)
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Original Research

Article
Delayed remission following sequential infusion of humanized CD19- and CD22-modified CAR-T cells in a patient with relapsed/refractory acute lymphoblastic leukemia and prior exposure to murine-derived CD19-directed CAR-T cells
Fei Yang, Jian Zhang, Xinyou Zhang, Mengli Tian, Jingjing Wang, Liqing Kang, Huiying Qiu & Depei Wu
Pages: 2187-2191
Published online: 25 Mar 2019
AbstractforDelayed remission following sequential infusion of humanized CD19- and CD22-modified CAR-T cells in a patient with relapsed/refractory acute lymphoblastic leukemia and prior exposure to murine-derived CD19-directed CAR-T cells | Full Text | References | PDF (1,016 KB)
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Article
LINC01296 promotes proliferation, migration, and invasion of HCC cells by targeting miR-122-5P and modulating EMT activity
Yafeng Wan, Molin Li & Ping Huang
Pages: 2193-2203
Published online: 26 Mar 2019
AbstractforLINC01296 promotes proliferation, migration, and invasion of HCC cells by targeting miR-122-5P and modulating EMT activity | Full Text | References | PDF (5.2 MB)
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Article
Efficacy of on-demand intrahepatic arterial therapy in combination with sorafenib for advanced hepatocellular carcinoma
Kazuto Tajiri, Yuka Futsukaichi, Saito Kobayashi, Kohei Nagata, Satoshi Yasumura, Terumi Takahara, Masami Minemura & Ichiro Yasuda
Pages: 2205-2214
Published online: 26 Mar 2019
AbstractforEfficacy of on-demand intrahepatic arterial therapy in combination with sorafenib for advanced hepatocellular carcinoma | Full Text | References | PDF (412.6 KB)
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Article
The impact of adjuvant radiotherapy on molecular prognostic markers in gliomas
Maciej Harat, Maciej Blok, Aleksandra Harat & Krystyna Soszyńska
Pages: 2215-2224
Published online: 26 Mar 2019
AbstractforThe impact of adjuvant radiotherapy on molecular prognostic markers in gliomas | Full Text | References | PDF (374.1 KB)
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Article
Effect of Th9/IL-9 on the growth of gastric cancer in nude mice
Li Cai, Yue Zhang, Yifei Zhang, Hongbing Chen & Jinchen Hu
Pages: 2225-2234
Published online: 26 Mar 2019
AbstractforEffect of Th9/IL-9 on the growth of gastric cancer in nude mice | Full Text | References | PDF (3.8 MB)
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Article
TRIB3 suppresses proliferation and invasion and promotes apoptosis of endometrial cancer cells by regulating the AKT signaling pathway
Junjie Qu, Binya Liu, Bilan Li, Guiqiang Du, Yiran Li, Jingyun Wang, Laman He & Xiaoping Wan
Pages: 2235-2245
Published online: 27 Mar 2019
AbstractforTRIB3 suppresses proliferation and invasion and promotes apoptosis of endometrial cancer cells by regulating the AKT signaling pathway | Full Text | References | PDF (2.4 MB)
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Article
MDM2 promotes epithelial–mesenchymal transition through activation of Smad2/3 signaling pathway in lung adenocarcinoma
Yong Tang, Yiwen Xuan, Guibin Qiao, Zhu’an Ou, Zhe He, Qihang Zhu, Ming Liao & Guilin Yin
Pages: 2247-2258
Published online: 27 Mar 2019
AbstractforMDM2 promotes epithelial–mesenchymal transition through activation of Smad2/3 signaling pathway in lung adenocarcinoma | Full Text | References | PDF (6.6 MB)
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Article
A novel curcumin derivative CL-6 exerts antitumor effect in human gastric cancer cells by inducing apoptosis through Hippo–YAP signaling pathway
Chenmin Ye, Wenqian Wang, Guojun Xia, Chengyang Yu, Yongdong Yi, Chunyan Hua, Fuyang Tu, Leibin Shen, Canjin Chen, Weijian Sun & Zhiqiang Zheng
Pages: 2259-2269
Published online: 27 Mar 2019
AbstractforA novel curcumin derivative CL-6 exerts antitumor effect in human gastric cancer cells by inducing apoptosis through Hippo–YAP signaling pathway | Full Text | References | PDF (5.7 MB)
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Review

Review Article
Selecting treatment options in refractory metastatic colorectal cancer
Margaret Byrne & Muhammad Wasif Saif
Pages: 2271-2278
Published online: 27 Mar 2019
AbstractforSelecting treatment options in refractory metastatic colorectal cancer | Full Text | References | PDF (259 KB)
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Review Article
Management of recurrent Ewing sarcoma: challenges and approaches
David Van Mater & Lars Wagner
Pages: 2279-2288
Published online: 27 Mar 2019
AbstractforManagement of recurrent Ewing sarcoma: challenges and approaches | Full Text | References | PDF (254.9 KB)
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Original Research

Article
TRIM31 promotes glioma proliferation and invasion through activating NF-κB pathway
Li Zhou, Zhe-Zhi Deng, Hai-Yan Li, Nan Jiang, Zhi-Sheng Wei, Ming-Fan Hong, Xiao-Dang Chen, Ji-Hui Wang, Ming-Xing Zhang, Yi-Hua Shi, Zheng-Qi Lu & Xu-Ming Huang
Pages: 2289-2297
Published online: 27 Mar 2019
AbstractforTRIM31 promotes glioma proliferation and invasion through activating NF-κB pathway | Full Text | References | PDF (2.2 MB)
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Article
Development and validation of prognostic nomograms for medullary thyroid cancer
Yong-jun Guan, Shi-ying Fang, Lin-lin Chen & Zheng-dong Li
Pages: 2299-2309
Published online: 27 Mar 2019
AbstractforDevelopment and validation of prognostic nomograms for medullary thyroid cancer | Full Text | References | PDF (1.1 MB)
  • 30 Views
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Article
Molecular subtype classification of papillary renal cell cancer using miRNA expression
Changwen Yu, Danjing Dai & Juan Xie
Pages: 2311-2322
Published online: 29 Mar 2019
AbstractforMolecular subtype classification of papillary renal cell cancer using miRNA expression | Full Text | References | PDF (15.2 MB)
  • 32 Views
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Article
MicroRNA-221 promotes papillary thyroid carcinoma cell migration and invasion via targeting RECK and regulating epithelial–mesenchymal transition
Zhao-li Wei, Ai-bin Gao, Qing Wang, Xiu-e Lou, Jing Zhao & Qing-jun Lu
Pages: 2323-2333
Published online: 28 Mar 2019
AbstractforMicroRNA-221 promotes papillary thyroid carcinoma cell migration and invasion via targeting RECK and regulating epithelial–mesenchymal transition | Full Text | References | PDF (4 MB)
  • 33 Views
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Article
Comparison of CHOP vs CHOPE for treatment of peripheral T-cell lymphoma: a meta-analysis
Shu Deng, Shenyun Lin, Jianping Shen & Yuqing Zeng
Pages: 2335-2342
Published online: 28 Mar 2019
AbstractforComparison of CHOP vs CHOPE for treatment of peripheral T-cell lymphoma: a meta-analysis | Full Text | References | PDF (880.1 KB)
  • 51 Views
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Article
1,25-Dihydroxyvitamin D3 affects gastric cancer progression by repressing BMP3 promoter methylation
Ye Zhao, Liang-Liang Cai, Hui-Ling Wang, Xiao-Juan Shi, Hui-Ming Ye, Ping Song, Bao-Qi Huang & Chi-Meng Tzeng
Pages: 2343-2353
Published online: 28 Mar 2019
Abstractfor1,25-Dihydroxyvitamin D3 affects gastric cancer progression by repressing BMP3 promoter methylation | Full Text | References | PDF (1.4 MB)
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Article
Tumor necrosis factor α knockout impaired tumorigenesis in chronic myeloid leukemia cells partly by metabolism modification and miRNA regulation
Na Shen, Songya Liu, Jieke Cui, Qing Li, Yong You, Zhaodong Zhong, Fanjun Cheng, An-Yuan Guo, Ping Zou, Guolin Yuan & Xiaojian Zhu
Pages: 2355-2364
Published online: 29 Mar 2019
AbstractforTumor necrosis factor α knockout impaired tumorigenesis in chronic myeloid leukemia cells partly by metabolism modification and miRNA regulation | Full Text | References | PDF (2.5 MB)
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Case Report

Case Report
Postchemotherapy sarcoma as a somatic-type malignancy derived from the gonadal yolk sac tumor in a patient with 46, XY pure gonadal dysgenesis
Xuan Zong, Jia-Xin Yang, Ying Zhang, Dong-Yan Cao, Keng Shen, Yan You & Li-Na Guo
Pages: 2365-2372
Published online: 28 Mar 2019
AbstractforPostchemotherapy sarcoma as a somatic-type malignancy derived from the gonadal yolk sac tumor in a patient with 46, XY pure gonadal dysgenesis | Full Text | References | PDF (4.8 MB)
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Original Research

Article
Overexpression of miR-664 is associated with poor overall survival and accelerates cell proliferation, migration and invasion in hepatocellular carcinoma
Xianming Wang, Zhengtong Zhou, Tao Zhang, Minghai Wang, Rongwei Xu, Shiyong Qin & Shuguang Zhang
Pages: 2373-2381
Published online: 28 Mar 2019
AbstractforOverexpression of miR-664 is associated with poor overall survival and accelerates cell proliferation, migration and invasion in hepatocellular carcinoma | Full Text | References | PDF (1 MB)
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Article
Luteolin suppresses tumor proliferation through inducing apoptosis and autophagy via MAPK activation in glioma
Yijie You, Rong Wang, Naiyuan Shao, Feng Zhi & Yilin Yang
Pages: 2383-2396
Published online: 28 Mar 2019
AbstractforLuteolin suppresses tumor proliferation through inducing apoptosis and autophagy via MAPK activation in glioma | Full Text | References | PDF (3.5 MB)
  • 48 Views
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Article
SIRT4 inhibits the proliferation, migration, and invasion abilities of thyroid cancer cells by inhibiting glutamine metabolism
Zhouxun Chen, Jiahao Lin, Shuyi Feng, Xuxu Chen, Hanzhang Huang, Chen Wang, Yujun Yu, Yu He, Shaoliang Han, Linfeng Zheng & Guoyu Huang
Pages: 2397-2408
Published online: 28 Mar 2019
AbstractforSIRT4 inhibits the proliferation, migration, and invasion abilities of thyroid cancer cells by inhibiting glutamine metabolism | Full Text | References | PDF (4.4 MB)
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Article
Histone deacetylase 6 is overexpressed and promotes tumor growth of colon cancer through regulation of the MAPK/ERK signal pathway
Shi-Lan Zhang, Hong-Yi Zhu, Bing-Yi Zhou, Yi Chu, Ji-Rong Huo, Yu-Yong Tan & De-Liang Liu
Pages: 2409-2419
Published online: 02 Apr 2019
AbstractforHistone deacetylase 6 is overexpressed and promotes tumor growth of colon cancer through regulation of the MAPK/ERK signal pathway | Full Text | References | PDF (492.3 KB)
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Case Report

Case Report
Clinical treatment of advanced synchronous triple primary malignancies: comprehensive treatment based on targeted therapy
Ying Zhang, Yunjie Ge, Xiaohui Wu & Shuangmei Liu
Pages: 2421-2430
Published online: 02 Apr 2019
AbstractforClinical treatment of advanced synchronous triple primary malignancies: comprehensive treatment based on targeted therapy | Full Text | References | PDF (921.9 KB)
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Case Report
Hepatopulmonary syndrome after radiofrequency ablation of recurrent intrahepatic cholangiocarcinoma: a case report
Yu Wang, Kuansheng Ma, Ai Zhong, Qing Xiong & Jian Chen
Pages: 2431-2438
Published online: 02 Apr 2019
AbstractforHepatopulmonary syndrome after radiofrequency ablation of recurrent intrahepatic cholangiocarcinoma: a case report | Full Text | References | PDF (4.2 MB)
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Original Research

Article
Differentiation antagonizing non-protein coding RNA modulates the proliferation, migration, and angiogenesis of glioma cells by targeting the miR-216a/LGR5 axis and the PI3K/AKT signaling pathway
Wei Wang, Yulian Li, Qinghai Ma, Haicheng Yan & Wuyun Su
Pages: 2439-2449
Published online: 04 Apr 2019
AbstractforDifferentiation antagonizing non-protein coding RNA modulates the proliferation, migration, and angiogenesis of glioma cells by targeting the miR-216a/LGR5 axis and the PI3K/AKT signaling pathway | Full Text | References | PDF (790.4 KB)
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Article
LKB1 suppresses glioma cell invasion via NF-κB/Snail signaling repression
Ye Yuan, Shi-Lin Li, Yu-Lin Cao, Jun-Jun Li & Qiang-Ping Wang
Pages: 2451-2463
Published online: 02 Apr 2019
AbstractforLKB1 suppresses glioma cell invasion via NF-κB/Snail signaling repression | Full Text | References | PDF (10.4 MB)
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Article
SOX5 promotes cell invasion and metastasis via activation of Twist-mediated epithelial–mesenchymal transition in gastric cancer
Jianxiong You, Qing Zhao, Xindong Fan & Jingbing Wang
Pages: 2465-2476
Published online: 03 Apr 2019
AbstractforSOX5 promotes cell invasion and metastasis via activation of Twist-mediated epithelial–mesenchymal transition in gastric cancer | Full Text | References | PDF (2.3 MB)
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Article
Combination treatment with cetuximab in advanced nasopharyngeal carcinoma patients: a meta-analysis
Jia Shen, Changling Sun, Min Zhou & Zhen Zhang
Pages: 2477-2494
Published online: 03 Apr 2019
AbstractforCombination treatment with cetuximab in advanced nasopharyngeal carcinoma patients: a meta-analysis | Full Text | References | PDF (1.9 MB)
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Article
Association of polymorphisms in MALAT1 with the risk of esophageal squamous cell carcinoma in a Chinese population
Yan Qu, Na Shao, Wenjing Yang, Jianbo Wang & Yufeng Cheng
Pages: 2495-2503
Published online: 03 Apr 2019
AbstractforAssociation of polymorphisms in MALAT1 with the risk of esophageal squamous cell carcinoma in a Chinese population | Full Text | References | PDF (283.9 KB)
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Review

Review Article
Durvalumab for the management of urothelial carcinoma: a short review on the emerging data and therapeutic potential
Capucine Baldini, Stéphane Champiat, Perrine Vuagnat & Christophe Massard
Pages: 2505-2512
Published online: 03 Apr 2019
AbstractforDurvalumab for the management of urothelial carcinoma: a short review on the emerging data and therapeutic potential | Full Text | References | PDF (881.9 KB)
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Original Research

Article
Clinical outcome of osteosarcoma and its correlation with programmed death-ligand 1 and T cell activation markers
Kazushige Yoshida, Masanori Okamoto, Jun Sasaki, Chika Kuroda, Haruka Ishida, Katsuya Ueda, Satomi Okano, Hirokazu Ideta, Takayuki Kamanaka, Atsushi Sobajima, Takashi Takizawa, Munehisa Kito, Kaoru Aoki, Takeshi Uemura, Hisao Haniu, Hiroyuki Kato & Naoto Saito
Pages: 2513-2518
Published online: 03 Apr 2019
AbstractforClinical outcome of osteosarcoma and its correlation with programmed death-ligand 1 and T cell activation markers | Full Text | References | PDF (463.3 KB)
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Article
SIRT1 inhibits hepatocellular carcinoma metastasis by promoting M1 macrophage polarization via NF-κB pathway
Bei Zhou, Yun Yang & Cuiping Li
Pages: 2519-2529
Published online: 04 Apr 2019
AbstractforSIRT1 inhibits hepatocellular carcinoma metastasis by promoting M1 macrophage polarization via NF-κB pathway | Full Text | References | PDF (1.9 MB)
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Case Report

Case Report
Long-term response of metastatic renal clear cell carcinoma following a subcutaneous injection of mixed bacterial vaccine: a case report
Jibing Chen, Youyong Lv, Feng Mu & Kecheng Xu
Pages: 2531-2538
Published online: 05 Apr 2019
AbstractforLong-term response of metastatic renal clear cell carcinoma following a subcutaneous injection of mixed bacterial vaccine: a case report | Full Text | References | PDF (2.6 MB)
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Original Research

Article
The diagnostic value of circulating tumor cells and ctDNA for gene mutations in lung cancer
Mengyuan Lyu, Jian Zhou, Kang Ning & Binwu Ying
Pages: 2539-2552
Published online: 05 Apr 2019
AbstractforThe diagnostic value of circulating tumor cells and ctDNA for gene mutations in lung cancer | Full Text | References | PDF (2.2 MB)
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Article
Silencing UBE4B induces nasopharyngeal carcinoma apoptosis through the activation of caspase3 and p53
Chengyin Weng, Yong Chen, Yong Wu, Xia Liu, Haibo Mao, Xisheng Fang, Baoxiu Li, Lina Wang, Mingmei Guan, Guolong Liu, Lin Lu & Yawei Yuan
Pages: 2553-2561
Published online: 08 Apr 2019
AbstractforSilencing UBE4B induces nasopharyngeal carcinoma apoptosis through the activation of caspase3 and p53 | Full Text | References | PDF (1.9 MB)
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Article
LncRNA PVT1 promotes proliferation, invasion and epithelial–mesenchymal transition of renal cell carcinoma cells through downregulation of miR-16-5p
Yu Ren, Weiping Huang, Guobin Weng, Pinger Cui, Haote Liang & Yeping Li
Pages: 2563-2575
Published online: 05 Apr 2019
AbstractforLncRNA PVT1 promotes proliferation, invasion and epithelial–mesenchymal transition of renal cell carcinoma cells through downregulation of miR-16-5p | Full Text | References | PDF (2.6 MB)
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Article
Clinical efficacy and survival analysis of apatinib combined with docetaxel in advanced esophageal cancer
Jing Li, Yongxu Jia, Yaping Gao, Zhiwei Chang, Huiqiong Han, Jie Yan & Yanru Qin
Pages: 2577-2583
Published online: 08 Apr 2019
AbstractforClinical efficacy and survival analysis of apatinib combined with docetaxel in advanced esophageal cancer | Full Text | References | PDF (384.4 KB)
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Article
SMYD2-OE promotes oxaliplatin resistance in colon cancer through MDR1/P-glycoprotein via MEK/ERK/AP1 pathway
Hailiang Ren, Zheng Wang, Yao Chen, Yanjun Liu, Shu Zhang, Tongtong Zhang & Yuntao Li
Pages: 2585-2594
Published online: 08 Apr 2019
AbstractforSMYD2-OE promotes oxaliplatin resistance in colon cancer through MDR1/P-glycoprotein via MEK/ERK/AP1 pathway | Full Text | References | PDF (2.8 MB)
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Article
Long noncoding RNA LINC00515 promotes cell proliferation and inhibits apoptosis by sponging miR-16 and activating PRMT5 expression in human glioma
Zhangyi Wu & Yihai Lin
Pages: 2595-2604
Published online: 08 Apr 2019
AbstractforLong noncoding RNA LINC00515 promotes cell proliferation and inhibits apoptosis by sponging miR-16 and activating PRMT5 expression in human glioma | Full Text | References | PDF (648.2 KB)
  • 31 Views
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Article
Shikonin-induced necroptosis in nasopharyngeal carcinoma cells via ROS overproduction and upregulation of RIPK1/RIPK3/MLKL expression
Tiancong Liu, Xun Sun & Zhiwei Cao
Pages: 2605-2614
Published online: 09 Apr 2019
AbstractforShikonin-induced necroptosis in nasopharyngeal carcinoma cells via ROS overproduction and upregulation of RIPK1/RIPK3/MLKL expression | Full Text | References | PDF (712.4 KB)
  • 99 Views
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Article
RETRACTED ARTICLE: miRNA-99b-5p targets FZD8 to inhibit non-small cell lung cancer proliferation, migration and invasion
Rui Liu, Yajuan Chen, Tao Shou, Jing Hu & Chen Qing
Pages: 2615-2621
Published online: 08 Apr 2019
AbstractforRETRACTED ARTICLE: miRNA-99b-5p targets FZD8 to inhibit non-small cell lung cancer proliferation, migration and invasion | PDF (2.3 MB)
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Article
Diagnostic value of circular RNAs as effective biomarkers for cancer: a systematic review and meta-analysis
Hong Tan, Li Gan, Xiaoming Fan, Limin Liu & Shan Liu
Pages: 2623-2633
Published online: 10 Apr 2019
AbstractforDiagnostic value of circular RNAs as effective biomarkers for cancer: a systematic review and meta-analysis | Full Text | References | PDF (798.4 KB)
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Article
High aspartate transaminase/alanine transaminase ratio predicts poor prognosis in patients with localized upper tract urothelial cancer: a propensity score-matched study in a large Chinese center
Yifan Li, Dong Fang, Zhengqing Bao, Anbang He, Bao Guan, Shiming He, Yonghao Zhan, Yanqing Gong, Xuesong Li & Liqun Zhou
Pages: 2635-2648
Published online: 11 Apr 2019
AbstractforHigh aspartate transaminase/alanine transaminase ratio predicts poor prognosis in patients with localized upper tract urothelial cancer: a propensity score-matched study in a large Chinese center | Full Text | References | PDF (461 KB)
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Article
lncRNA KCNQ1OT1 enhances the chemoresistance of oxaliplatin in colon cancer by targeting the miR-34a/ATG4B pathway
Yongchao Li, Changfeng Li, Dandan Li, Lei Yang, Jingpeng Jin & Bin Zhang
Pages: 2649-2660
Published online: 09 Apr 2019
AbstractforlncRNA KCNQ1OT1 enhances the chemoresistance of oxaliplatin in colon cancer by targeting the miR-34a/ATG4B pathway | Full Text | References | PDF (2.9 MB)
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Article
Cell-free miR-17-5p as a diagnostic biomarker for gastric cancer inhibits dendritic cell maturation
Zi-Jin Cui, Xiao-Li Xie, Wei Qi, Yi-Chao Yang, Yun Bai, Jing Han, Qian Ding & Hui-Qing Jiang
Pages: 2661-2675
Published online: 09 Apr 2019
AbstractforCell-free miR-17-5p as a diagnostic biomarker for gastric cancer inhibits dendritic cell maturation | Full Text | References | PDF (1.8 MB)
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Article
Overexpression of PRR11 promotes tumorigenic capability and is associated with progression in esophageal squamous cell carcinoma
Li Zhou, Zhe-Zhi Deng, Hai-Yan Li, Nan Jiang, Zhi-Sheng Wei, Ming-Fan Hong, Ji-Hui Wang, Ming-Xing Zhang, Yi-Hua Shi, Zheng-Qi Lu & Xu-Ming Huang
Pages: 2677-2693
Published online: 09 Apr 2019
AbstractforOverexpression of PRR11 promotes tumorigenic capability and is associated with progression in esophageal squamous cell carcinoma | Full Text | References | PDF (4.5 MB)
  • 31 Views
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Article
Clinicopathological impacts of c-Met overexpression in bladder cancer: evidence from 1,336 cases
Xin Xu, Guanjun Zhang, Liujia He & Yi Zhu
Pages: 2695-2702
Published online: 10 Apr 2019
AbstractforClinicopathological impacts of c-Met overexpression in bladder cancer: evidence from 1,336 cases | Full Text | References | PDF (500.1 KB)
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Article
IL-37 promotes cell apoptosis in cervical cancer involving Bim upregulation
Ping Ouyang, Weifang An, Renhuai Chen, He Zhang, Danrui Chen, Enping Jiang, Wei Zhu, Peng Li, Hongsheng Guo, Zhangquan Chen & Sen Wang
Pages: 2703-2712
Published online: 10 Apr 2019
AbstractforIL-37 promotes cell apoptosis in cervical cancer involving Bim upregulation | Full Text | References | PDF (675.5 KB)
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Article
miR-19 promotes the proliferation of clear cell renal cell carcinoma by targeting the FRK–PTEN axis
Zhi-Fei Jing, Jian-Bin Bi, Ze-Liang Li, Xian-Kui Liu, Jun Li, Yu-Yan Zhu, Xiao-Tong Zhang, Zhe Zhang, Zhen-Hua Li & Chui-Ze Kong
Pages: 2713-2727
Published online: 10 Apr 2019
AbstractformiR-19 promotes the proliferation of clear cell renal cell carcinoma by targeting the FRK–PTEN axis | Full Text | References | PDF (6.4 MB)
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Case Report

Article
Successful treatment of brain radiation necrosis resulting from triple-negative breast cancer with Endostar and short-term hyperbaric oxygen therapy: a case report
Shiyun Xing, Zhenhai Fan, Lei Shi, Ze Yang & Yuju Bai
Pages: 2729-2735
Published online: 10 Apr 2019
AbstractforSuccessful treatment of brain radiation necrosis resulting from triple-negative breast cancer with Endostar and short-term hyperbaric oxygen therapy: a case report | Full Text | References | PDF (570.7 KB)
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Original Research

Article
Whole transcriptome sequencing identifies crucial genes associated with colon cancer and elucidation of their possible mechanisms of action
Yang Yang, Yanan Zhao, Wenlong Zhang & Yuansong Bai
Pages: 2737-2747
Published online: 10 Apr 2019
AbstractforWhole transcriptome sequencing identifies crucial genes associated with colon cancer and elucidation of their possible mechanisms of action | Full Text | References | PDF (2.4 MB)
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Corrigendum

Correction
Efficacy and safety of apatinib treatment for gastric cancer, hepatocellular carcinoma and non-small cell lung cancer: a meta-analysis [Corrigendum]
Page: 2749
Published online: 11 Apr 2019
CitationforEfficacy and safety of apatinib treatment for gastric cancer, hepatocellular carcinoma and non-small cell lung cancer: a meta-analysis [Corrigendum] | Full Text | PDF (154.7 KB)
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Original Research

Article
Rituximab-based combination therapy in patients with Waldenström macroglobulinemia: a systematic review and meta-analysis
Yan-Hua Zheng, Li Xu, Chun Cao, Juan Feng, Hai-Long Tang, Mi-Mi Shu, Guang-Xun Gao & Xie-Qun Chen
Pages: 2751-2766
Published online: 11 Apr 2019
AbstractforRituximab-based combination therapy in patients with Waldenström macroglobulinemia: a systematic review and meta-analysis | Full Text | References | PDF (1.6 MB)
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Article
The proliferation of cervical cancer is promoted by miRNA-125b through the regulation of the HMGA1
Bingmei Sun, Ying Zhang, Lianxiang Zhou, Linin Yin, Fei Li, Chao Li & Jiayu Xia
Pages: 2767-2776
Published online: 11 Apr 2019
AbstractforThe proliferation of cervical cancer is promoted by miRNA-125b through the regulation of the HMGA1 | Full Text | References | PDF (1.2 MB)
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Article
Pyrotinib treatment on HER2-positive gastric cancer cells promotes the released exosomes to enhance endothelial cell progression, which can be counteracted by apatinib
Zhengxing Gao, Chunqing Song, Guangxin Li, Haishan Lin, Xiangyao Lian, Ninggang Zhang & Bangwei Cao
Pages: 2777-2787
Published online: 11 Apr 2019
AbstractforPyrotinib treatment on HER2-positive gastric cancer cells promotes the released exosomes to enhance endothelial cell progression, which can be counteracted by apatinib | Full Text | References | PDF (935.4 KB)
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Article
Stanniocalcin 1 in tumor microenvironment promotes metastasis of ovarian cancer
Yuqi Yang, Sheng Yin, Shuqing Li, Yaping Chen & Lina Yang
Pages: 2789-2798
Published online: 11 Apr 2019
AbstractforStanniocalcin 1 in tumor microenvironment promotes metastasis of ovarian cancer | Full Text | References | PDF (682.1 KB)
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Article
Aberrant expression of PAFAH1B3 associates with poor prognosis and affects proliferation and aggressiveness in hypopharyngeal squamous cell carcinoma
Jianing Xu, Yuanwei Zang, Shengda Cao, Dapeng Lei & Xinliang Pan
Pages: 2799-2808
Published online: 11 Apr 2019
AbstractforAberrant expression of PAFAH1B3 associates with poor prognosis and affects proliferation and aggressiveness in hypopharyngeal squamous cell carcinoma | Full Text | References | PDF (4.2 MB)
  • 26 Views
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Article
MicroRNA-940 restricts the expression of metastasis-associated gene MACC1 and enhances the antitumor effect of Anlotinib on colorectal cancer
Yan Wang, Meng Zhao, Huishan Zhao, Shi Cheng, Rixing Bai & Maomin Song
Pages: 2809-2822
Published online: 12 Apr 2019
AbstractforMicroRNA-940 restricts the expression of metastasis-associated gene MACC1 and enhances the antitumor effect of Anlotinib on colorectal cancer | Full Text | References | PDF (859.1 KB)
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Case Report

Case Report
Sunitinib-and-Chinese herbal medicine-based systematic treatment clinically cured a patient with multiple metastatic primary clear cell carcinoma of the liver: a case report
Lingling Sun, Hanrui Chen, Zhiwei Xiao, Wei Guo & Lizhu Lin
Pages: 2823-2828
Published online: 12 Apr 2019
AbstractforSunitinib-and-Chinese herbal medicine-based systematic treatment clinically cured a patient with multiple metastatic primary clear cell carcinoma of the liver: a case report | Full Text | References | PDF (2.8 MB)
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Original Research

Article
FAM111B, a direct target of p53, promotes the malignant process of lung adenocarcinoma
Haijun Sun, Kaichao Liu, Jianfeng Huang, Qi Sun, Chenye Shao, Jing Luo, Lin Xu, Yi Shen & Binhui Ren
Pages: 2829-2842
Published online: 17 Apr 2019
AbstractforFAM111B, a direct target of p53, promotes the malignant process of lung adenocarcinoma | Full Text | References | PDF (4.3 MB)
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Article
Decreased expression of aquaporin 1 correlates with clinicopathological features of patients with cervical cancer
Min Wei, Hailang Yu, Yanling Zhang, Jun Zeng, Cuixia Cai & Rong Shi
Pages: 2843-2851
Published online: 23 Apr 2019
AbstractforDecreased expression of aquaporin 1 correlates with clinicopathological features of patients with cervical cancer | Full Text | References | PDF (1.7 MB)
  • 35 Views
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Article
Prognostic significance of EIF4G1 in patients with pancreatic ductal adenocarcinoma
Tae Sik Goh, Mihyang Ha, Jung Sub Lee, Dae Cheon Jeong, Eun Sang Jung, Myoung-Eun Han, Yun Hak Kim & Sae-Ock Oh
Pages: 2853-2859
Published online: 15 Apr 2019
AbstractforPrognostic significance of EIF4G1 in patients with pancreatic ductal adenocarcinoma | Full Text | References | PDF (953.4 KB)
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Article
SIRT6 promotes the Warburg effect of papillary thyroid cancer cell BCPAP through reactive oxygen species
Weiping Yu, Zhou Yang, Renhong Huang, Zhijun Min & Min Ye
Pages: 2861-2868
Published online: 15 Apr 2019
AbstractforSIRT6 promotes the Warburg effect of papillary thyroid cancer cell BCPAP through reactive oxygen species | Full Text | References | PDF (566 KB)
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Article
Notch pathway is involved in the suppression of colorectal cancer by embryonic stem cell microenvironment
Guanghui Lan, Zongwei Lin, Jinhui Zhang, Li Liu, Jianjun Zhang, Lei Zheng & Qiong Luo
Pages: 2869-2878
Published online: 16 Apr 2019
AbstractforNotch pathway is involved in the suppression of colorectal cancer by embryonic stem cell microenvironment | Full Text | References | PDF (2.8 MB)
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Article
Leptin rs7799039 (G2548A) polymorphism is associated with cancer risk: a meta-analysis involving 25,799 subjects
Weifeng Tang, Mingqiang Kang, Chao Liu & Hao Qiu
Pages: 2879-2890
Published online: 16 Apr 2019
AbstractforLeptin rs7799039 (G2548A) polymorphism is associated with cancer risk: a meta-analysis involving 25,799 subjects | Full Text | References | PDF (2 MB)
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Article
Nr5a2 promotes tumor growth and metastasis of gastric cancer AGS cells by Wnt/beta-catenin signaling
Lei Liu, Yan Li, Biran Pan, Tongtong Zhang, Danfeng Wei, Yifang Zhu & Yuanbiao Guo
Pages: 2891-2902
Published online: 17 Apr 2019
AbstractforNr5a2 promotes tumor growth and metastasis of gastric cancer AGS cells by Wnt/beta-catenin signaling | Full Text | References | PDF (2.4 MB)
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Review

Review Article
MDM2 antagonists as a novel treatment option for acute myeloid leukemia: perspectives on the therapeutic potential of idasanutlin (RG7388)
Arushi Khurana & Danielle A Shafer
Pages: 2903-2910
Published online: 16 Apr 2019
AbstractforMDM2 antagonists as a novel treatment option for acute myeloid leukemia: perspectives on the therapeutic potential of idasanutlin (RG7388) | Full Text | References | PDF (265.8 KB)
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Original Research

Article
Neuropilin-1 is associated with the prognosis of cervical cancer in Henan Chinese population
Li Yang, Ling Liu, Yuan-Hang Zhu, Bing-Bing Wang, Yan-Nan Chen, Feng Zhang, Xiao-An Zhang & Chen-Chen Ren
Pages: 2911-2920
Published online: 17 Apr 2019
AbstractforNeuropilin-1 is associated with the prognosis of cervical cancer in Henan Chinese population | Full Text | References | PDF (2 MB)
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Article
Downregulation of survivin by adenovirus-mediated shRNA promotes apoptosis in skin cancer cells
Yuqin Hao, Xuefeng Bai, Xia Liu, Shuxia Kang, Xin Zhang, Caiyun Liu & Zhehai Li
Pages: 2921-2930
Published online: 17 Apr 2019
AbstractforDownregulation of survivin by adenovirus-mediated shRNA promotes apoptosis in skin cancer cells | Full Text | References | PDF (1.9 MB)
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Case Report

Case Report
A significant response to a combination of trastuzumab and vinorelbine in HER2-negative metastatic breast cancer with HER2 V777L mutation
Lei Lei, Wei-Wu Ye, Lin-Feng Zheng, Ping Huang, Lei Shi, Jian Huang, Ya-Bing Zheng, Zhan-Hong Chen, Xiao-Jia Wang & Xian Wang
Pages: 2931-2936
Published online: 17 Apr 2019
AbstractforA significant response to a combination of trastuzumab and vinorelbine in HER2-negative metastatic breast cancer with HER2 V777L mutation | Full Text | References | PDF (2.6 MB)
  • 31 Views
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Case Report
CD5-negative chronic lymphocytic leukemia/small lymphocytic lymphoma in a patient with gastrointestinal mantle cell lymphoma: an unusual case report
Dangui Chen, Yang Zhan, Jun Peng & Fusheng Yao
Pages: 2937-2941
Published online: 17 Apr 2019
AbstractforCD5-negative chronic lymphocytic leukemia/small lymphocytic lymphoma in a patient with gastrointestinal mantle cell lymphoma: an unusual case report | Full Text | References | PDF (1.1 MB)
  • 48 Views
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Case Report
Refinement of diagnosis and supporting evidence for the use of immunotherapy through sequential biopsies in a case of EML4-ALK positive lung cancer
Peng Song, Jingcheng Zhang & Li Zhang
Pages: 2943-2948
Published online: 17 Apr 2019
AbstractforRefinement of diagnosis and supporting evidence for the use of immunotherapy through sequential biopsies in a case of EML4-ALK positive lung cancer | Full Text | References | PDF (3 MB)
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Case Report
Successful treatment with cryoablation in a patient with bone metastasis in the mid-shaft femur: a case report
Kouji Kita, Tomoki Nakamura, Takashi Yamanaka, Keisuke Yoshida, Tomohito Hagi, Kunihiro Asanuma, Atsuhiro Nakatsuka & Akihiro Sudo
Pages: 2949-2953
Published online: 17 Apr 2019
AbstractforSuccessful treatment with cryoablation in a patient with bone metastasis in the mid-shaft femur: a case report | Full Text | References | PDF (2.3 MB)
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Original Research

Article
Expression of FOXP1 and FOXO3a in extrahepatic cholangiocarcinoma and the implications in clinicopathological significance and prognosis
Jun He, Zhulin Yang, Zhengchun Wu, Lingxiang Wang, Shu Xu, Qiong Zou, Yuan Yuan & Daiqiang Li
Pages: 2955-2965
Published online: 17 Apr 2019
AbstractforExpression of FOXP1 and FOXO3a in extrahepatic cholangiocarcinoma and the implications in clinicopathological significance and prognosis | Full Text | References | PDF (4.4 MB)
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Article
LncRNA MIR100HG promotes cancer cell proliferation, migration and invasion in laryngeal squamous cell carcinoma through the downregulation of miR-204-5p
Yongyang Huang, Chao Zhang & Yanhui Zhou
Pages: 2967-2973
Published online: 17 Apr 2019
AbstractforLncRNA MIR100HG promotes cancer cell proliferation, migration and invasion in laryngeal squamous cell carcinoma through the downregulation of miR-204-5p | Full Text | References | PDF (1.4 MB)
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Case Report

Case Report
Large-cell neuroendocrine carcinoma of nasal cavity and paranasal sinuses after successful curative therapy: a case report and literature review
Qin Zhao, Jinlong Wei, Chengbin Zhang, Lingbin Meng, Bin Wang, Ling Gao & Xin Jiang
Pages: 2975-2980
Published online: 17 Apr 2019
AbstractforLarge-cell neuroendocrine carcinoma of nasal cavity and paranasal sinuses after successful curative therapy: a case report and literature review | Full Text | References | PDF (4.8 MB)
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Original Research

Article
Profile of lenvatinib in the treatment of hepatocellular carcinoma: design, development, potential place in therapy and network meta-analysis of hepatitis B and hepatitis C in all Phase III trials
Andrea Casadei Gardini, Marco Puzzoni, Francesco Montagnani, Giorgia Marisi, Emiliano Tamburini, Alessandro Cucchetti, Leonardo Solaini, Francesco Giuseppe Foschi, Fabio Conti, Giorgio Ercolani, Stefano Cascinu & Mario Scartozzi
Pages: 2981-2988
Published online: 24 Apr 2019
AbstractforProfile of lenvatinib in the treatment of hepatocellular carcinoma: design, development, potential place in therapy and network meta-analysis of hepatitis B and hepatitis C in all Phase III trials | Full Text | References | PDF (1.9 MB)
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Expert Opinion

Editorial
Treating advanced breast cancer with metronomic chemotherapy: what is known, what is new and what is the future?
Marina Elena Cazzaniga, Laura Biganzoli, Laura Cortesi, Sabino De Placido, Michela Donadio, Alessandra Fabi, Antonella Ferro, Daniele Generali, Vito Lorusso, Andrea Milani, Emilia Montagna, Elisabetta Munzone, Laura Orlando, Laura Pizzuti, Edda Simoncini, Claudio Zamagni, Giovanni L Pappagallo & On behalf of the “Metronomic Chemotherapy in Advanced Breast Cancer” Study Group
Pages: 2989-2997
Published online: 23 Apr 2019
AbstractforTreating advanced breast cancer with metronomic chemotherapy: what is known, what is new and what is the future? | Full Text | References | PDF (244.4 KB)
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Open Access

Original Research

Article
MiR-216b suppresses cell proliferation, migration, invasion, and epithelial–mesenchymal transition by regulating FOXM1 expression in human non-small cell lung cancer
Lidong Wang, Yansen Wang, Xiangyang Du, Yanfen Yao, Lei Wang & Yawei Jia
Pages: 2999-3009
Published online: 18 Apr 2019
AbstractforMiR-216b suppresses cell proliferation, migration, invasion, and epithelial–mesenchymal transition by regulating FOXM1 expression in human non-small cell lung cancer | Full Text | References | PDF (3.6 MB)
  • 79 Views
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Article
CD40L inhibits cell growth of THP-1 cells by suppressing the PI3K/Akt pathway
Zhongxin Feng, Qi Chen, Mingqiang Ren, Zuguo Tian & Yuping Gong
Pages: 3011-3017
Published online: 18 Apr 2019
AbstractforCD40L inhibits cell growth of THP-1 cells by suppressing the PI3K/Akt pathway | Full Text | References | PDF (3.2 MB)
  • 35 Views
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Open Access
Article
NRF3 suppresses breast cancer cell metastasis and cell proliferation and is a favorable predictor of survival in breast cancer
Jianguo Sun, Zhibao Zheng, Qi Chen, Yin Pan, Hongsheng Lu, Hui Zhang, Yingzhi Yu & Yuechu Dai
Pages: 3019-3030
Published online: 18 Apr 2019
AbstractforNRF3 suppresses breast cancer cell metastasis and cell proliferation and is a favorable predictor of survival in breast cancer | Full Text | References | PDF (2.9 MB)
  • 46 Views
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Open Access
Article
ZNF277 regulates ovarian cancer cell proliferation and invasion through inhibition of PTEN
Zhengling Liu, Zonglan Xu, Yonghui Tian, Hua Yan & Yanyan Lou
Pages: 3031-3042
Published online: 18 Apr 2019
AbstractforZNF277 regulates ovarian cancer cell proliferation and invasion through inhibition of PTEN | Full Text | References | PDF (2.2 MB)
  • 36 Views
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Article
Pim-1 inhibitor SMI-4a suppresses tumor growth in non-small cell lung cancer via PI3K/AKT/mTOR pathway
Wenjie Jiang, Yuan Chen, Xing Song, Yingjie Shao, Zhonghua Ning & Wendong Gu
Pages: 3043-3050
Published online: 23 Apr 2019
AbstractforPim-1 inhibitor SMI-4a suppresses tumor growth in non-small cell lung cancer via PI3K/AKT/mTOR pathway | Full Text | References | PDF (1.9 MB)
  • 37 Views
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Open Access
Article
M2 macrophages confer resistance to 5-fluorouracil in colorectal cancer through the activation of CCL22/PI3K/AKT signaling
Chen Wei, Chaogang Yang, Shuyi Wang, Dongdong Shi, Chunxiao Zhang, Xiaobin Lin & Bin Xiong
Pages: 3051-3063
Published online: 18 Apr 2019
AbstractforM2 macrophages confer resistance to 5-fluorouracil in colorectal cancer through the activation of CCL22/PI3K/AKT signaling | Full Text | References | PDF (2.6 MB)
  • 57 Views
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Open Access
Article
hMOF reduction enhances radiosensitivity through the homologous recombination pathway in non-small-cell lung cancer
Nan Li, Guang-Wei Tian, Ling-Rong Tang & Guang Li
Pages: 3065-3075
Published online: 23 Apr 2019
AbstractforhMOF reduction enhances radiosensitivity through the homologous recombination pathway in non-small-cell lung cancer | Full Text | References | PDF (5.7 MB)
  • 34 Views
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Open Access
Article
Modified FOLFIRINOX for unresectable locally advanced/metastatic pancreatic cancer. A real-world comparison of an attenuated with a full dose in a single center experience
Luigi Cavanna, Elisa Maria Stroppa, Chiara Citterio, Patrizia Mordenti, Camilla Di Nunzio, Silvia Peveri, Elena Orlandi & Stefano Vecchia
Pages: 3077-3085
Published online: 23 Apr 2019
AbstractforModified FOLFIRINOX for unresectable locally advanced/metastatic pancreatic cancer. A real-world comparison of an attenuated with a full dose in a single center experience | Full Text | References | PDF (583.3 KB)
  • 50 Views
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Open Access
Article
Retinoic acid receptor α facilitates human colorectal cancer progression via Akt and MMP2 signaling
Gui-Li Huang, Qing-Xi Chen, Jia-Jia Ma, Si-Yao Sui, Yu-Ning Wang & Dong-Yan Shen
Pages: 3087-3098
Published online: 23 Apr 2019
AbstractforRetinoic acid receptor α facilitates human colorectal cancer progression via Akt and MMP2 signaling | Full Text | References | PDF (4.3 MB)
  • 33 Views
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Article
MiR-145 inhibits EGF-induced epithelial-to-mesenchymal transition via targeting Smad2 in human glioblastoma
Weijie Chen, Baochen Huang, Enqin Wang & Xingqiang Wang
Pages: 3099-3107
Published online: 23 Apr 2019
AbstractforMiR-145 inhibits EGF-induced epithelial-to-mesenchymal transition via targeting Smad2 in human glioblastoma | Full Text | References | PDF (2.6 MB)
  • 84 Views
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Open Access
Article
INPP4B promotes colorectal cancer cell proliferation by activating mTORC1 signaling and cap-dependent translation
Xin-Hua Ruan, Xi-Mei Liu, Zhi-Xiang Yang, Shao-Peng Zhang, Quan-Zheng Li & Chun-Sheng Lin
Pages: 3109-3117
Published online: 23 Apr 2019
AbstractforINPP4B promotes colorectal cancer cell proliferation by activating mTORC1 signaling and cap-dependent translation | Full Text | References | PDF (932.2 KB)
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Open Access

Review

Review Article
Expression level and clinical significance of SNHG1 in human cancers: a meta-analysis
Yang Yu, Jian Yang, Shengquan Yang, Quanpeng Li, Mingjiong Zhang, Lijuan Wang, Guozhong Ji & Lin Miao
Pages: 3119-3127
Published online: 24 Apr 2019
AbstractforExpression level and clinical significance of SNHG1 in human cancers: a meta-analysis | Full Text | References | PDF (2.4 MB)
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Open Access

Original Research

Article
Expression and significance of LncRNA MNX1-AS1 in non-small cell lung cancer
Gaofeng Liu, Xiaofeng Guo, Yong Zhang, Yan Liu, Dandan Li, Guangyao Tang & Sujuan Cui
Pages: 3129-3138
Published online: 26 Apr 2019
AbstractforExpression and significance of LncRNA MNX1-AS1 in non-small cell lung cancer | Full Text | References | PDF (2.5 MB)
  • 36 Views
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Open Access
Article
Cinobufotalin as an effective adjuvant therapy for advanced gastric cancer: a meta-analysis of randomized controlled trials
Huiling Sun, Wenxiao Wang, Minghua Bai & Dongling Liu
Pages: 3139-3160
Published online: 26 Apr 2019
AbstractforCinobufotalin as an effective adjuvant therapy for advanced gastric cancer: a meta-analysis of randomized controlled trials | Full Text | References | PDF (7.9 MB)
  • 82 Views
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Open Access
Article
GADD45α-targeted suicide gene therapy driven by synthetic CArG promoter E9NS sensitizes NSCLC cells to cisplatin, resveratrol, and radiation regardless of p53 status
Qiwen Shi, Vijaykumar Sutariya, Sheeba Varghese Gupta & Deepak Bhatia
Pages: 3161-3170
Published online: 26 Apr 2019
AbstractforGADD45α-targeted suicide gene therapy driven by synthetic CArG promoter E9NS sensitizes NSCLC cells to cisplatin, resveratrol, and radiation regardless of p53 status | Full Text | References | PDF (3.5 MB)
  • 40 Views
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Open Access

Review

Article
Antitumor activity of larotrectinib in tumors harboring NTRK gene fusions: a short review on the current evidence
Biagio Ricciuti, Carlo Genova, Lucio Crinò, Massimo Libra & Giulia Costanza Leonardi
Pages: 3171-3179
Published online: 30 Apr 2019
AbstractforAntitumor activity of larotrectinib in tumors harboring NTRK gene fusions: a short review on the current evidence | Full Text | References | PDF (442.3 KB)
  • 56 Views
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Original Research

Article
MiR-155-5p accelerates the metastasis of cervical cancer cell via targeting TP53INP1
Ning Li, Tao Cui, Wenling Guo, Dianwei Wang & Li Mao
Pages: 3181-3196
Published online: 29 Apr 2019
AbstractforMiR-155-5p accelerates the metastasis of cervical cancer cell via targeting TP53INP1 | Full Text | References | PDF (5.6 MB)
  • 71 Views
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Open Access
Article
RETRACTED ARTICLE: Exosomal Tenascin-c induces proliferation and invasion of pancreatic cancer cells by WNT signaling
Songying Qian, Xiaodong Tan, Xinlu Liu, Peng Liu & Yunhao Wu
Pages: 3197-3205
Published online: 29 Apr 2019
AbstractforRETRACTED ARTICLE: Exosomal Tenascin-c induces proliferation and invasion of pancreatic cancer cells by WNT signaling | PDF (2.2 MB)
  • 28 Views
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Open Access
Article
Fibronectin 1 promotes melanoma proliferation and metastasis by inhibiting apoptosis and regulating EMT
Bifei Li, Weiyu Shen, Huayi Peng, Yumei Li, Fan Chen, Liping Zheng, Jianhua Xu & Lee Jia
Pages: 3207-3221
Published online: 01 May 2019
AbstractforFibronectin 1 promotes melanoma proliferation and metastasis by inhibiting apoptosis and regulating EMT | Full Text | References | PDF (5.4 MB)
  • 100 Views
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Open Access
Article
Numb inhibits cell proliferation, invasion, and epithelial–mesenchymal transition through PAK1/β-catenin signaling pathway in ovarian cancer
Jiabin Liang, Bingbing Han, Yunhe Zhang & Qingfen Yue
Pages: 3223-3233
Published online: 29 Apr 2019
AbstractforNumb inhibits cell proliferation, invasion, and epithelial–mesenchymal transition through PAK1/β-catenin signaling pathway in ovarian cancer | Full Text | References | PDF (2.5 MB)
  • 33 Views
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Open Access

Review

Review Article
NUT midline carcinoma of the head and neck: current perspectives
M Napolitano, M Venturelli, E Molinaro & A Toss
Pages: 3235-3244
Published online: 30 Apr 2019
AbstractforNUT midline carcinoma of the head and neck: current perspectives | Full Text | References | PDF (663.8 KB)
  • 62 Views
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Review Article
Advancements of Annexin A1 in inflammation and tumorigenesis
Gang Shao, Hanwei Zhou, Qiyu Zhang, Yuanting Jin & Caiyun Fu
Pages: 3245-3254
Published online: 30 Apr 2019
AbstractforAdvancements of Annexin A1 in inflammation and tumorigenesis | Full Text | References | PDF (1.1 MB)
  • 59 Views
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Original Research

Article
RETRACTED ARTICLE: MicroRNA-143-3p suppresses tumorigenesis by targeting catenin-δ1 in colorectal cancer
Xiaohua Ding, Jiying Du, Kai Mao, Xiaoyu Wang, Yuange Ding & Fanping Wang
Pages: 3255-3265
Published online: 01 May 2019
AbstractforRETRACTED ARTICLE: MicroRNA-143-3p suppresses tumorigenesis by targeting catenin-δ1 in colorectal cancer | PDF (1.6 MB)
  • 9 Views
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Open Access
Article
Ribonucleotide reductase subunit M2 as a novel target for clear-cell renal cell carcinoma
Yun Zou, Juan Zhou, Bin Xu, Wenzhi Li & Zhong Wang
Pages: 3267-3275
Published online: 30 Apr 2019
AbstractforRibonucleotide reductase subunit M2 as a novel target for clear-cell renal cell carcinoma | Full Text | References | PDF (1.4 MB)
  • 93 Views
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Open Access
Article
Crossover safety study of aprepitant: 2-min injection vs 30-min infusion in cancer patients receiving emetogenic chemotherapy
Rudolph M Navari & Michael C Mosier
Pages: 3277-3284
Published online: 30 Apr 2019
AbstractforCrossover safety study of aprepitant: 2-min injection vs 30-min infusion in cancer patients receiving emetogenic chemotherapy | Full Text | References | PDF (454.6 KB)
  • 124 Views
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Article
MEX3C regulates lipid metabolism to promote bladder tumorigenesis through JNK pathway
Haichao Chao, Leihong Deng, Fanghua Xu, Zhaojun Yu, Xiangda Xu, Jianbiao Huang & Tao Zeng
Pages: 3285-3294
Published online: 01 May 2019
AbstractforMEX3C regulates lipid metabolism to promote bladder tumorigenesis through JNK pathway | Full Text | References | PDF (3.1 MB)
  • 46 Views
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Open Access
Article
Increased MCL-1 expression predicts poor prognosis and disease recurrence in acute myeloid leukemia
Xi-xi Li, Jing-dong Zhou, Xiang-mei Wen, Ting-juan Zhang, De-hong Wu, Zhao-qun Deng, Zhi-hui Zhang, Xin-yue Lian, Pin-fang He, Xin-yu Yao, Jiang Lin & Jun Qian
Pages: 3295-3304
Published online: 01 May 2019
AbstractforIncreased MCL-1 expression predicts poor prognosis and disease recurrence in acute myeloid leukemia | Full Text | References | PDF (1.6 MB)
  • 34 Views
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Open Access
Article
High feasibility of cytological specimens for detection of ROS1 fusion by reverse transcriptase PCR in Chinese patients with advanced non-small-cell lung cancer
Limin Zhang, Yan Wang, Chao Zhao, Jinpeng Shi, Sha Zhao, Xiaozhen Liu, Yijun Jia, Tao Zhu, Tao Jiang, Xuefei Li & Caicun Zhou
Pages: 3305-3311
Published online: 01 May 2019
AbstractforHigh feasibility of cytological specimens for detection of ROS1 fusion by reverse transcriptase PCR in Chinese patients with advanced non-small-cell lung cancer | Full Text | References | PDF (426.3 KB)
  • 36 Views
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Open Access
Article
Altered circulating levels of adipokine omentin-1 in patients with prostate cancer
Lin Zhou, Weiming He, Wenjun Wang & Daoping Zhou
Pages: 3313-3319
Published online: 01 May 2019
AbstractforAltered circulating levels of adipokine omentin-1 in patients with prostate cancer | Full Text | References | PDF (268 KB)
  • 43 Views
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Open Access

Case Report

Case Report
Poor prognosis of pulmonary sarcomatoid carcinoma with KRAS mutation and ALK fusion
Fangmin Chen, Qihua Gu, Chengping Hu, Xiaoling Cai & Shuhua Lei
Pages: 3321-3325
Published online: 01 May 2019
AbstractforPoor prognosis of pulmonary sarcomatoid carcinoma with KRAS mutation and ALK fusion | Full Text | References | PDF (3.9 MB)
  • 37 Views
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Open Access

Original Research

Article
Nicotine promotes cervical metastasis of oral cancer by regulating peroxiredoxin 1 and epithelial–mesenchymal transition in mice
Min Wang, Wenwen Niu, Moci Qi, Hui Chen, Min Zhang, Chunxiao Wang, Lihua Ge, Jing Yang, Congcong Miao, Ni Shi, Tong Chen & Xiaofei Tang
Pages: 3327-3338
Published online: 01 May 2019
AbstractforNicotine promotes cervical metastasis of oral cancer by regulating peroxiredoxin 1 and epithelial–mesenchymal transition in mice | Full Text | References | PDF (2.4 MB)
  • 34 Views
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Open Access
Article
Fatty acid synthase enhances colorectal cancer cell proliferation and metastasis via regulating AMPK/mTOR pathway
Ting Lu, Liang Sun, Zhiyi Wang, Yu Zhang, Zhilong He & Chunfang Xu
Pages: 3339-3347
Published online: 02 May 2019
AbstractforFatty acid synthase enhances colorectal cancer cell proliferation and metastasis via regulating AMPK/mTOR pathway | Full Text | References | PDF (1.3 MB)
  • 57 Views
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Open Access
Article
LncRNA SNHG6 promotes the migration, invasion, and epithelial-mesenchymal transition of colorectal cancer cells by miR-26a/EZH2 axis
Mingyuan Zhang, Wenbiao Duan & Weiliang Sun
Pages: 3349-3360
Published online: 02 May 2019
AbstractforLncRNA SNHG6 promotes the migration, invasion, and epithelial-mesenchymal transition of colorectal cancer cells by miR-26a/EZH2 axis | Full Text | References | PDF (2.4 MB)
  • 36 Views
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Open Access

Corrigendum

Correction
Overexpression of APC11 predicts worse survival in lung adenocarcinoma [Corrigendum]
Pages: 3361-3362
Published online: 02 May 2019
CitationforOverexpression of APC11 predicts worse survival in lung adenocarcinoma [Corrigendum] | Full Text | PDF (758 KB)
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Open Access

Original Research

Article
CircHIPK3 overexpression accelerates the proliferation and invasion of prostate cancer cells through regulating miRNA-338-3p
Chengkuan Cai, Yunlai Zhi, Kunpeng Wang, Pengcheng Zhang, Zhenshuai Ji, Cheng Xie & Fanghu Sun
Pages: 3363-3372
Published online: 02 May 2019
AbstractforCircHIPK3 overexpression accelerates the proliferation and invasion of prostate cancer cells through regulating miRNA-338-3p | Full Text | References | PDF (1.9 MB)
  • 32 Views
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Open Access

Case Report

Review Article
Multiple myeloma with dural mater involvement
Su Liu, Xubin Li, Yueyang Li, Dongying Li, Yafei Wang & Chen Tian
Pages: 3373-3375
Published online: 03 May 2019
AbstractforMultiple myeloma with dural mater involvement | Full Text | References | PDF (523.2 KB)
  • 68 Views
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Original Research

Article
Long non-coding RNA CASC2 serves as a ceRNA of microRNA-21 to promote PDCD4 expression in oral squamous cell carcinoma
Lina Pan, Hui Chen, Yang Bai, Qibao Wang & Liang Chen
Pages: 3377-3385
Published online: 06 May 2019
AbstractforLong non-coding RNA CASC2 serves as a ceRNA of microRNA-21 to promote PDCD4 expression in oral squamous cell carcinoma | Full Text | References | PDF (2.3 MB)
  • 37 Views
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Open Access

Review

Review Article
Pancreatic cancer in young adults: changes, challenges, and solutions
Florian Primavesi, Stefan Stättner, Konstantin Schlick, Tobias Kiesslich, Christian Mayr, Eckhard Klieser, Romana Urbas & Daniel Neureiter
Pages: 3387-3400
Published online: 06 May 2019
AbstractforPancreatic cancer in young adults: changes, challenges, and solutions | Full Text | References | PDF (648.9 KB)
  • 61 Views
  • 15 CrossRef citations
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Open Access

Original Research

Article
Assessment of tumor mutation burden calculation from gene panel sequencing data
Zhenwu Xu, Jiawei Dai, Dandan Wang, Hui Lu, Heng Dai, Hao Ye, Jianlei Gu, Shengjia Chen & Bingding Huang
Pages: 3401-3409
Published online: 06 May 2019
AbstractforAssessment of tumor mutation burden calculation from gene panel sequencing data | Full Text | References | PDF (2.7 MB)
  • 63 Views
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Open Access

Review

Review Article
Research progress of cystatin SN in cancer
Yanfang Liu & Jing Yao
Pages: 3411-3419
Published online: 06 May 2019
AbstractforResearch progress of cystatin SN in cancer | Full Text | References | PDF (1.4 MB)
  • 52 Views
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Original Research

Article
KIAA1429 regulates the migration and invasion of hepatocellular carcinoma by altering m6A modification of ID2 mRNA
Xiaoyu Cheng, Ming Li, Xi Rao, Wenfeng Zhang, Xiaopeng Li, Liang Wang & Guanjun Huang
Pages: 3421-3428
Published online: 07 May 2019
AbstractforKIAA1429 regulates the migration and invasion of hepatocellular carcinoma by altering m6A modification of ID2 mRNA | Full Text | References | PDF (1.9 MB)
  • 51 Views
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Open Access
Article
The functions of microRNA-124 on bladder cancer
Zhigang Cao, Li Xu, Shuli Zhao & Xu Zhu
Pages: 3429-3439
Published online: 07 May 2019
AbstractforThe functions of microRNA-124 on bladder cancer | Full Text | References | PDF (3.2 MB)
  • 28 Views
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Open Access
Article
Collagen stiffness promoted non-muscle-invasive bladder cancer progression to muscle-invasive bladder cancer
Huier Zhu, Hui Chen, Jizhong Wang, Ling Zhou & Shaoyan Liu
Pages: 3441-3457
Published online: 07 May 2019
AbstractforCollagen stiffness promoted non-muscle-invasive bladder cancer progression to muscle-invasive bladder cancer | Full Text | References | PDF (7.5 MB)
  • 60 Views
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Open Access
Article
The clinical efficacy of ultrasound-guided percutaneous microwave ablation for rib metastases with severe intractable pain: a preliminary clinical study
Zhigang Cheng, Xin Li, Chao An, Xiaoling Yu, Jie Yu, Zhiyu Han, Fangyi Liu & Ping Liang
Pages: 3459-3465
Published online: 07 May 2019
AbstractforThe clinical efficacy of ultrasound-guided percutaneous microwave ablation for rib metastases with severe intractable pain: a preliminary clinical study | Full Text | References | PDF (971.1 KB)
  • 24 Views
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Open Access
Article
Long noncoding RNA UBE2R2-AS1 promotes glioma cell apoptosis via targeting the miR-877-3p/TLR4 axis
Wu Xu, Guo-Qing Hu, Clive Da Costa, Jun-Hai Tang, Qing-Rui Li, Lei Du, Ya-Wen Pan & Sheng-Qing Lv
Pages: 3467-3480
Published online: 07 May 2019
AbstractforLong noncoding RNA UBE2R2-AS1 promotes glioma cell apoptosis via targeting the miR-877-3p/TLR4 axis | Full Text | References | PDF (5.1 MB)
  • 36 Views
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Article
miR-125a-5p inhibits colorectal cancer cell epithelial–mesenchymal transition, invasion and migration by targeting TAZ
Lei Tang, Li Zhou, Shengchun Wu, Xiaoming Shi, Guangwei Jiang, Shuai Niu & Dianzhu Ding
Pages: 3481-3489
Published online: 07 May 2019
AbstractformiR-125a-5p inhibits colorectal cancer cell epithelial–mesenchymal transition, invasion and migration by targeting TAZ | Full Text | References | PDF (4 MB)
  • 31 Views
  • 24 CrossRef citations
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Article
INPP4B inhibits cell proliferation, invasion and chemoresistance in human hepatocellular carcinoma
Wendong Tang, Liwen Yang, Taoyu Yang, Min Liu, Yanjie Zhou, Jiang Lin, Ke Wang & Chenbo Ding
Pages: 3491-3507
Published online: 07 May 2019
AbstractforINPP4B inhibits cell proliferation, invasion and chemoresistance in human hepatocellular carcinoma | Full Text | References | PDF (6.5 MB)
  • 32 Views
  • 10 CrossRef citations
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Article
Long non-coding RNA homeobox A11 antisense RNA (HOXA11-AS) promotes retinoblastoma progression via sponging miR-506-3p
Ning Han, Ling Zuo, Han Chen, Chunxia Zhang, Pei He & Hongtao Yan
Pages: 3509-3517
Published online: 07 May 2019
AbstractforLong non-coding RNA homeobox A11 antisense RNA (HOXA11-AS) promotes retinoblastoma progression via sponging miR-506-3p | Full Text | References | PDF (2.6 MB)
  • 29 Views
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Article
c-Src is required for hypoxia-induced metastasis-associated functions in prostate cancer cells
Yao Dai & Dietmar Siemann
Pages: 3519-3529
Published online: 08 May 2019
Abstractforc-Src is required for hypoxia-induced metastasis-associated functions in prostate cancer cells | Full Text | References | PDF (3.8 MB)
  • 49 Views
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Article
miR-129-5p inhibits prostate cancer proliferation via targeting ETV1
Ge Gao, Dianhui Xiu, Bin Yang, Daju Sun, Xin Wei, Youpeng Ding, Yanan Ma & Zhixin Wang
Pages: 3531-3544
Published online: 09 May 2019
AbstractformiR-129-5p inhibits prostate cancer proliferation via targeting ETV1 | Full Text | References | PDF (1.7 MB)
  • 42 Views
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Open Access
Article
Identification of novel biomarkers and candidate small molecule drugs in non-small-cell lung cancer by integrated microarray analysis
Qiong Wu, Bo Zhang, Yidan Sun, Ran Xu, Xinyi Hu, Shiqi Ren, Qianqian Ma, Chen Chen, Jian Shu, Fuwei Qi, Ting He, Wei Wang & Ziheng Wang
Pages: 3545-3563
Published online: 13 May 2019
AbstractforIdentification of novel biomarkers and candidate small molecule drugs in non-small-cell lung cancer by integrated microarray analysis | Full Text | References | PDF (6.9 MB)
  • 70 Views
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Open Access
Article
Polymorphism of miRNA and esophageal cancer risk: an updated systemic review and meta-analysis
Xudong Guo, Lei Zhao, Yi Shen, Yi Shao, Wenqiang Wei & Fen Liu
Pages: 3565-3580
Published online: 23 May 2019
AbstractforPolymorphism of miRNA and esophageal cancer risk: an updated systemic review and meta-analysis | Full Text | References | PDF (2.9 MB)
  • 38 Views
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Open Access
Article
The reversal of MRP1 expression induced by low-frequency and low-intensity ultrasound and curcumin mediated by VEGF in brain glioma
Lei Yao & Zhen Zhang
Pages: 3581-3593
Published online: 13 May 2019
AbstractforThe reversal of MRP1 expression induced by low-frequency and low-intensity ultrasound and curcumin mediated by VEGF in brain glioma | Full Text | References | PDF (3.9 MB)
  • 37 Views
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Open Access
Article
miR-106b promotes proliferation and invasion by targeting Capicua through MAPK signaling in renal carcinoma cancer
Lu-Jie Miao, Shu Yan, Qian-Feng Zhuang, Qing-Yan Mao, Dong Xue, Xiao-Zhou He & Jian-Ping Chen
Pages: 3595-3607
Published online: 13 May 2019
AbstractformiR-106b promotes proliferation and invasion by targeting Capicua through MAPK signaling in renal carcinoma cancer | Full Text | References | PDF (3.7 MB)
  • 37 Views
  • 14 CrossRef citations
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Open Access

Review

Review Article
Clinicopathological and prognostic significance of Nanog expression in non-small cell lung cancer: a meta-analysis
Guichuan Huang, Jing Zhang, Xin Wang, Yi Chen, Daishun Liu & Shuliang Guo
Pages: 3609-3617
Published online: 13 May 2019
AbstractforClinicopathological and prognostic significance of Nanog expression in non-small cell lung cancer: a meta-analysis | Full Text | References | PDF (1.1 MB)
  • 32 Views
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Review Article
Novel cancer therapy targeting microbiome
Tatsuya Nagano, Takehiro Otoshi, Daisuke Hazama, Tatsunori Kiriu, Kanoko Umezawa, Naoko Katsurada & Yoshihiro Nishimura
Pages: 3619-3624
Published online: 13 May 2019
AbstractforNovel cancer therapy targeting microbiome | Full Text | References | PDF (226.1 KB)
  • 62 Views
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Original Research

Article
PAQR4 promotes cell proliferation and metastasis through the CDK4-pRB-E2F1 pathway in non-small-cell lung cancer
Bin Wu & Rongyu Liu
Pages: 3625-3633
Published online: 13 May 2019
AbstractforPAQR4 promotes cell proliferation and metastasis through the CDK4-pRB-E2F1 pathway in non-small-cell lung cancer | Full Text | References | PDF (2 MB)
  • 33 Views
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Open Access

Case Report

Case Report
Long-term progression-free survival of apatinib monotherapy for relapsed ovarian cancer: a case report and literature review
Di Zhang, Jiaqi Huang, Yulan Sun & Qisen Guo
Pages: 3635-3644
Published online: 15 May 2019
AbstractforLong-term progression-free survival of apatinib monotherapy for relapsed ovarian cancer: a case report and literature review | Full Text | References | PDF (2.4 MB)
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Review

Review Article
The role of circadian clock genes in tumors
Han-Xue Li
Pages: 3645-3660
Published online: 13 May 2019
AbstractforThe role of circadian clock genes in tumors | Full Text | References | PDF (660.3 KB)
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Article
Insulin-like growth factor II mRNA-binding protein 3 promotes cell proliferation, migration and invasion in human glioblastoma
Chao Wu, Hongxin Ma, Guijun Qi, Fanyu Chen & Jiancheng Chu
Pages: 3661-3670
Published online: 15 May 2019
AbstractforInsulin-like growth factor II mRNA-binding protein 3 promotes cell proliferation, migration and invasion in human glioblastoma | Full Text | References | PDF (2.6 MB)
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Review

Review Article
Prognostic and clinicopathological value of PD-L1 in colorectal cancer: a systematic review and meta-analysis
Lianzhou Yang, Rujun Xue & Chunhua Pan
Pages: 3671-3682
Published online: 14 May 2019
AbstractforPrognostic and clinicopathological value of PD-L1 in colorectal cancer: a systematic review and meta-analysis | Full Text | References | PDF (2.4 MB)
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Article
Identification of key genes and pathways in seminoma by bioinformatics analysis
Ye-Hui Chen, Ting-Ting Lin, Yu-Peng Wu, Xiao-Dong Li, Shao-Hao Chen, Xue-Yi Xue, Yong Wei, Qing-Shui Zheng, Jin-Bei Huang & Ning Xu
Pages: 3683-3693
Published online: 14 May 2019
AbstractforIdentification of key genes and pathways in seminoma by bioinformatics analysis | Full Text | References | PDF (1.8 MB)
  • 60 Views
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Article
Identification and validation of an individualized autophagy-clinical prognostic index in bladder cancer patients
Shi-Shuo Wang, Gang Chen, Sheng-Hua Li, Jin-Shu Pang, Kai-Teng Cai, Hai-Biao Yan, Zhi-Guang Huang & Rong-Quan He
Pages: 3695-3712
Published online: 14 May 2019
AbstractforIdentification and validation of an individualized autophagy-clinical prognostic index in bladder cancer patients | Full Text | References | PDF (4.3 MB)
  • 31 Views
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Article
Anti-tumor effect of aloe-emodin on cervical cancer cells was associated with human papillomavirus E6/E7 and glucose metabolism
Rui Gao, Xiaowen Wu, Zhi Huang, Bi Wang, Fenghu Li, Hui Xu & Li Ran
Pages: 3713-3721
Published online: 14 May 2019
AbstractforAnti-tumor effect of aloe-emodin on cervical cancer cells was associated with human papillomavirus E6/E7 and glucose metabolism | Full Text | References | PDF (3.8 MB)
  • 91 Views
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Article
Efficacy and tolerability of stereotactic body radiotherapy for lung metastases in three patients with pediatric malignancies
Jared Deck, Gary Eastwick, Jody Sima, Amanda Raymond, Jeffrey Bogart & Paul Aridgides
Pages: 3723-3727
Published online: 15 May 2019
AbstractforEfficacy and tolerability of stereotactic body radiotherapy for lung metastases in three patients with pediatric malignancies | Full Text | References | PDF (667.1 KB)
  • 42 Views
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Article
Downregulation of GBAS regulates oral squamous cell carcinoma proliferation and apoptosis via the p53 signaling pathway
Xing Wang, Yuting Bai, Ying Han, Jian Meng & Hongwei Liu
Pages: 3729-3742
Published online: 17 May 2019
AbstractforDownregulation of GBAS regulates oral squamous cell carcinoma proliferation and apoptosis via the p53 signaling pathway | Full Text | References | PDF (3.4 MB)
  • 34 Views
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Article
Homeobox B7 accelerates the cancer progression of gastric carcinoma cells by promoting epithelial–mesenchymal transition (EMT) and activating Src–FAK pathway
Jianghong Wu, Ziwen Long, Hong Cai, Shengjia Yu & Xiaowen Liu
Pages: 3743-3751
Published online: 16 May 2019
AbstractforHomeobox B7 accelerates the cancer progression of gastric carcinoma cells by promoting epithelial–mesenchymal transition (EMT) and activating Src–FAK pathway | Full Text | References | PDF (2.5 MB)
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Article
ITGBL1 promotes EMT, invasion and migration by activating NF-κB signaling pathway in prostate cancer
Wenze Li, Shuren Li, Jie Yang, Chunyan Cui, Miao Yu & Yadong Zhang
Pages: 3753-3763
Published online: 16 May 2019
AbstractforITGBL1 promotes EMT, invasion and migration by activating NF-κB signaling pathway in prostate cancer | Full Text | References | PDF (3.8 MB)
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Article
RETRACTED ARTICLE: microRNA-605 inhibits the oncogenicity of non-small-cell lung cancer by directly targeting Forkhead Box P1
Wei Zhou & Ruichao Li
Pages: 3765-3777
Published online: 17 May 2019
AbstractforRETRACTED ARTICLE: microRNA-605 inhibits the oncogenicity of non-small-cell lung cancer by directly targeting Forkhead Box P1 | PDF (3.9 MB)
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Article
LncRNA MIR210HG promotes proliferation and invasion of non-small cell lung cancer by upregulating methylation of CACNA2D2 promoter via binding to DNMT1
Xiaowen Kang, Fanwu Kong, Kun Huang, Lu Li, Zhaoguo Li, Xinyan Wang, Wei Zhang & Xiaomei Wu
Pages: 3779-3790
Published online: 16 May 2019
AbstractforLncRNA MIR210HG promotes proliferation and invasion of non-small cell lung cancer by upregulating methylation of CACNA2D2 promoter via binding to DNMT1 | Full Text | References | PDF (3.6 MB)
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Article
Prognostic value of preoperative computed tomography in HBV-related hepatocellular carcinoma patients after curative resection
Wei Zhang, Jie Chen, Lijuan Liu, Lili Wang, Junjie Liu & Danke Su
Pages: 3791-3804
Published online: 16 May 2019
AbstractforPrognostic value of preoperative computed tomography in HBV-related hepatocellular carcinoma patients after curative resection | Full Text | References | PDF (2.5 MB)
  • 59 Views
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Article
Irradiation increases the immunogenicity of lung cancer cells and irradiation-based tumor cell vaccine elicits tumor-specific T cell responses in vivo
Lumeng Luo, Minghe Lv, Xibing Zhuang, Qi Zhang & Tiankui Qiao
Pages: 3805-3815
Published online: 16 May 2019
AbstractforIrradiation increases the immunogenicity of lung cancer cells and irradiation-based tumor cell vaccine elicits tumor-specific T cell responses in vivo | Full Text | References | PDF (3.8 MB)
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Article
Prognostic significance and biological function of Lamina-associated polypeptide 2 in non-small-cell lung cancer
Chang Liu, Hui Yu, Xuxia Shen, Jie Qiao, Xianghua Wu, Jianhua Chang, Xunxia Zhu, Jialei Wang & Xiaoyong Shen
Pages: 3817-3827
Published online: 16 May 2019
AbstractforPrognostic significance and biological function of Lamina-associated polypeptide 2 in non-small-cell lung cancer | Full Text | References | PDF (2.2 MB)
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Article
MiR-449a regulates the cell migration and invasion of human non-small cell lung carcinoma by targeting ADAM10
Haining Meng, Qiao Huang, Xijin Zhang, Jiawei Huang, Ruowu Shen & Bei Zhang
Pages: 3829-3838
Published online: 16 May 2019
AbstractforMiR-449a regulates the cell migration and invasion of human non-small cell lung carcinoma by targeting ADAM10 | Full Text | References | PDF (1.9 MB)
  • 33 Views
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Article
Effect of XPC polymorphisms on the response to platinum-based chemotherapy: a meta-analysis
Chenyao Xie, Jing Zhao, Wenxi Hua, Pei Tan, Yudi Chen, Jingwen Rui, Xiaohan Sun, Jiaying Fan, Xiangyu Wei, Xiaojing Xu & Xiaoqin Yang
Pages: 3839-3848
Published online: 16 May 2019
AbstractforEffect of XPC polymorphisms on the response to platinum-based chemotherapy: a meta-analysis | Full Text | References | PDF (1.7 MB)
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Article
Impact of CXCR4 and CXCR7 knockout by CRISPR/Cas9 on the function of triple-negative breast cancer cells
Meng Yang, Chen Zeng, Peiting Li, Liyuan Qian, Boni Ding, Lihua Huang, Gang Li, Han Jiang, Ni Gong & Wei Wu
Pages: 3849-3858
Published online: 17 May 2019
AbstractforImpact of CXCR4 and CXCR7 knockout by CRISPR/Cas9 on the function of triple-negative breast cancer cells | Full Text | References | PDF (3.4 MB)
  • 149 Views
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Article
Proteomic analysis of cerebrospinal fluid in pediatric acute lymphoblastic leukemia patients: a pilot study
Linghong Guo, Honghong Ren, Hao Zeng, Yanqiu Gong & Xuelei Ma
Pages: 3859-3868
Published online: 17 May 2019
AbstractforProteomic analysis of cerebrospinal fluid in pediatric acute lymphoblastic leukemia patients: a pilot study | Full Text | References | PDF (2.2 MB)
  • 54 Views
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Article
Circular RNA CDR1as acts as a sponge of miR-135b-5p to suppress ovarian cancer progression
He Chen, Min Mao, Jing Jiang, Daling Zhu & Peiling Li
Pages: 3869-3879
Published online: 17 May 2019
AbstractforCircular RNA CDR1as acts as a sponge of miR-135b-5p to suppress ovarian cancer progression | Full Text | References | PDF (3 MB)
  • 124 Views
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Article
Mitochondria P-glycoprotein confers paclitaxel resistance on ovarian cancer cells
Weina Guo, Weihong Dong, Min Li & Yi Shen
Pages: 3881-3891
Published online: 17 May 2019
AbstractforMitochondria P-glycoprotein confers paclitaxel resistance on ovarian cancer cells | Full Text | References | PDF (2.2 MB)
  • 37 Views
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Article
Curcumin reverses oxaliplatin resistance in human colorectal cancer via regulation of TGF-β/Smad2/3 signaling pathway
Jiahuan Yin, Li Wang, Yong Wang, Hailong Shen, Xiaojie Wang & Lei Wu
Pages: 3893-3903
Published online: 17 May 2019
AbstractforCurcumin reverses oxaliplatin resistance in human colorectal cancer via regulation of TGF-β/Smad2/3 signaling pathway | Full Text | References | PDF (1.7 MB)
  • 56 Views
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Article
Artificial microenvironment of in vitro glioblastoma cell cultures changes profile of miRNAs related to tumor drug resistance
Monika Witusik-Perkowska, Magdalena Zakrzewska, Dariusz J Jaskolski, Pawel P Liberski & Janusz Szemraj
Pages: 3905-3918
Published online: 20 May 2019
AbstractforArtificial microenvironment of in vitro glioblastoma cell cultures changes profile of miRNAs related to tumor drug resistance | Full Text | References | PDF (5.2 MB)
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Article
A temperature-sensitive phase-change hydrogel of tamoxifen achieves the long-acting antitumor activation on breast cancer cells
Du Meng, Hongwei Lei, Xiaoqiang Zheng, Yaxuan Han, Ronggang Sun, Dongli Zhao & Rui Liu
Pages: 3919-3931
Published online: 24 May 2019
AbstractforA temperature-sensitive phase-change hydrogel of tamoxifen achieves the long-acting antitumor activation on breast cancer cells | Full Text | References | PDF (2.4 MB)
  • 66 Views
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Article
Downregulation of NSD3 (WHSC1L1) inhibits cell proliferation and migration via ERK1/2 deactivation and decreasing CAPG expression in colorectal cancer cells
Lanjuan Yi, Lanjie Yi, Qing Liu & Chen Li
Pages: 3933-3943
Published online: 21 May 2019
AbstractforDownregulation of NSD3 (WHSC1L1) inhibits cell proliferation and migration via ERK1/2 deactivation and decreasing CAPG expression in colorectal cancer cells | Full Text | References | PDF (2.3 MB)
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Article
LncRNA DLX6-AS1 promotes the proliferation, invasion, and migration of non-small cell lung cancer cells by targeting the miR-27b-3p/GSPT1 axis
Wen Sun, Liwen Zhang, Ranran Yan, Ying Yang & Xiangli Meng
Pages: 3945-3954
Published online: 22 May 2019
AbstractforLncRNA DLX6-AS1 promotes the proliferation, invasion, and migration of non-small cell lung cancer cells by targeting the miR-27b-3p/GSPT1 axis | Full Text | References | PDF (3 MB)
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Article
Serum starvation induces cell death in NSCLC via miR-224
Guoqin Wang, Jiangqiong Han, Li Zhuang, Shijuan Li, Quan Gong & Yunlan Chen
Pages: 3953-3962
Published online: 22 May 2019
AbstractforSerum starvation induces cell death in NSCLC via miR-224 | Full Text | References | PDF (3.4 MB)
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Article
MiR-1284 suppresses gastric cancer progression by targeting EIF4A1
Weiyuan Wei, Wenlong Cao, Zexu Zhan, Linhai Yan, Yubo Xie & Qiang Xiao
Pages: 3965-3976
Published online: 21 May 2019
AbstractforMiR-1284 suppresses gastric cancer progression by targeting EIF4A1 | Full Text | References | PDF (3.4 MB)
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Article
Insulin-like growth factor-1, metabolic abnormalities, and pathological complete remission rate in HER2-positive breast cancer patients receiving neoadjuvant therapy
Yi-Wei Tong, Gen Wang, Jia-Yi Wu, Ou Huang, Jian-Rong He, Li Zhu, Wei-Guo Chen, Ya-Fen Li, Xiao-Song Chen & Kun-Wei Shen
Pages: 3977-3989
Published online: 21 May 2019
AbstractforInsulin-like growth factor-1, metabolic abnormalities, and pathological complete remission rate in HER2-positive breast cancer patients receiving neoadjuvant therapy | Full Text | References | PDF (835.3 KB)
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Article
Analysis of risk factors for colon cancer progression
Zhou Yang, Yusheng Chen, Dejun Wu, Zhijun Min & Yingjun Quan
Pages: 3991-4000
Published online: 22 May 2019
AbstractforAnalysis of risk factors for colon cancer progression | Full Text | References | PDF (2.5 MB)
  • 125 Views
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Article
HEATR1 modulates cell survival in non-small cell lung cancer via activation of the p53/PUMA signaling pathway
Saifei He, Xing Ma, Ying Ye, Miao Zhang, Juhua Zhuang, Yanan Song & Wei Xia
Pages: 4001-4011
Published online: 21 May 2019
AbstractforHEATR1 modulates cell survival in non-small cell lung cancer via activation of the p53/PUMA signaling pathway | Full Text | References | PDF (2.1 MB)
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Article
LncRNA GAS5-mediated miR-1323 promotes tumor progression by targeting TP53INP1 in hepatocellular carcinoma
Fengjuan Zhang, Chao Yang, Zhiyuan Xing, Pei Liu, Bo Zhang, Xiang Ma, Liuye Huang & Likun Zhuang
Pages: 4013-4023
Published online: 21 May 2019
AbstractforLncRNA GAS5-mediated miR-1323 promotes tumor progression by targeting TP53INP1 in hepatocellular carcinoma | Full Text | References | PDF (2.8 MB)
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Article
Circular RNA hsa_circ_009755 downregulation correlates with clinicopathology in oral squamous cell carcinoma
Zihong Wang, Jing Tang, Yufan Wang, Shuai Sun, Yuling Chen, Yuehong Shen & Hong-Yu Yang
Pages: 4025-4031
Published online: 23 May 2019
AbstractforCircular RNA hsa_circ_009755 downregulation correlates with clinicopathology in oral squamous cell carcinoma | Full Text | References | PDF (2.1 MB)
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Article
Antitumor effects of conditioned media of human fetal dermal mesenchymal stem cells on melanoma cells
Bencheng Sun, Xiao Wang, Yi Pan, Ya Jiao, Yongjun Qi, Hongmin Gong & Duyin Jiang
Pages: 4033-4046
Published online: 28 May 2019
AbstractforAntitumor effects of conditioned media of human fetal dermal mesenchymal stem cells on melanoma cells | Full Text | References | PDF (7.5 MB)
  • 129 Views
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Article
Calotropin activates YAP through downregulation of LATS1 in colorectal cancer cells
Limin Zhou, Luliang Cai, Yanzi Guo, Huanyu Zhang, Peng Wang, Guohui Yi & Yonghao Huang
Pages: 4047-4054
Published online: 23 May 2019
AbstractforCalotropin activates YAP through downregulation of LATS1 in colorectal cancer cells | Full Text | References | PDF (2.3 MB)
  • 35 Views
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Article
TPM4 promotes cell migration by modulating F-actin formation in lung cancer
Xiaoting Zhao, Mei Jiang & Ziyu Wang
Pages: 4055-4063
Published online: 31 May 2019
AbstractforTPM4 promotes cell migration by modulating F-actin formation in lung cancer | Full Text | References | PDF (3.7 MB)
  • 198 Views
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Article
circANKS1B regulates FOXM1 expression and promotes cell migration and invasion by functioning as a sponge of the miR-149 in colorectal cancer
Dongzheng Li, Ruixue Yang, Liu Yang, Dongfeng Wang, Xin Zhou & Yan Sun
Pages: 4065-4073
Published online: 23 May 2019
AbstractforcircANKS1B regulates FOXM1 expression and promotes cell migration and invasion by functioning as a sponge of the miR-149 in colorectal cancer | Full Text | References | PDF (2.3 MB)
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Review

Review Article
Progress in the identification of gene mutations involved in multiple myeloma
Ying Hu, Wenming Chen & Jingbo Wang
Pages: 4075-4080
Published online: 24 May 2019
AbstractforProgress in the identification of gene mutations involved in multiple myeloma | Full Text | References | PDF (451.1 KB)
  • 55 Views
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Original Research

Article
ODC1 promotes proliferation and mobility via the AKT/GSK3β/β-catenin pathway and modulation of acidotic microenvironment in human hepatocellular carcinoma
Zi Ye, Zhirui Zeng, Yiyi Shen, Qiang Yang, Duidui Chen, Zubing Chen & Shiqiang Shen
Pages: 4081-4092
Published online: 27 May 2019
AbstractforODC1 promotes proliferation and mobility via the AKT/GSK3β/β-catenin pathway and modulation of acidotic microenvironment in human hepatocellular carcinoma | Full Text | References | PDF (3.4 MB)
  • 109 Views
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Case Report

Case Report
Anlotinib is effective in the treatment of advanced carcinoma ex pleomorphic adenoma of the submandibular gland
Shujie Song, Ping Sui, Minmin Li, Liangming Zhang & Dengjun Sun
Pages: 4093-4097
Published online: 24 May 2019
AbstractforAnlotinib is effective in the treatment of advanced carcinoma ex pleomorphic adenoma of the submandibular gland | Full Text | References | PDF (1.3 MB)
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Original Research

Article
Long non-coding RNA H19 promotes the proliferation and invasion of lung cancer cells and regulates the expression of E-cadherin, N-cadherin, and vimentin
Shu Liao, Chaxiu Yu, Hucheng Liu, Congkai Zhang, Yong Li & Xiaojun Zhong
Pages: 4099-4107
Published online: 24 May 2019
AbstractforLong non-coding RNA H19 promotes the proliferation and invasion of lung cancer cells and regulates the expression of E-cadherin, N-cadherin, and vimentin | Full Text | References | PDF (2.4 MB)
  • 53 Views
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Article
Grape seed procyanidin B2 promotes the autophagy and apoptosis in colorectal cancer cells via regulating PI3K/Akt signaling pathway
Ruijuan Zhang, Qianyun Yu, Wenqiang Lu, Jun Shen, Dongqing Zhou, Yingjue Wang, Shurong Gao & Zhijun Wang
Pages: 4109-4118
Published online: 24 May 2019
AbstractforGrape seed procyanidin B2 promotes the autophagy and apoptosis in colorectal cancer cells via regulating PI3K/Akt signaling pathway | Full Text | References | PDF (2.5 MB)
  • 51 Views
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Article
The anti-apoptotic effect on cancer-associated fibroblasts of B7-H3 molecule enhancing the cell invasion and metastasis in renal cancer
Shuai Zhang, Chenchao Zhou, Dongze Zhang, Ziyi Huang & Guangbo Zhang
Pages: 4119-4127
Published online: 24 May 2019
AbstractforThe anti-apoptotic effect on cancer-associated fibroblasts of B7-H3 molecule enhancing the cell invasion and metastasis in renal cancer | Full Text | References | PDF (2.1 MB)
  • 39 Views
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Review

Review Article
Progression of the role of CRYAB in signaling pathways and cancers
JunFei Zhang, Jia Liu, JiaLi Wu, WenFeng Li, ZhongWei Chen & LiShan Yang
Pages: 4129-4139
Published online: 30 May 2019
AbstractforProgression of the role of CRYAB in signaling pathways and cancers | Full Text | References | PDF (792.4 KB)
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Original Research

Article
ITGA3 serves as a diagnostic and prognostic biomarker for pancreatic cancer
Yan Jiao, Yanqing Li, Songyang Liu, Qingmin Chen & Yahui Liu
Pages: 4141-4152
Published online: 27 May 2019
AbstractforITGA3 serves as a diagnostic and prognostic biomarker for pancreatic cancer | Full Text | References | PDF (3.7 MB)
  • 87 Views
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Article
Identification of key genes and pathways in Ewing’s sarcoma patients associated with metastasis and poor prognosis
Guoqi Li, Piao Zhang, Wenkan Zhang, Zhong Lei, Jiaming He, Jiahong Meng, Tuoyu Di & Weiqi Yan
Pages: 4153-4165
Published online: 27 May 2019
AbstractforIdentification of key genes and pathways in Ewing’s sarcoma patients associated with metastasis and poor prognosis | Full Text | References | PDF (4.3 MB)
  • 44 Views
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Article
RETRACTED ARTICLE: microRNA-612 suppresses the malignant development of non-small-cell lung cancer by directly targeting bromodomain-containing protein 4
Xiaowen Kang, Fanwu Kong, Shijie Wu, Qiushuang Liu, Chengcheng Yang, Xiaomei Wu & Wei Zhang
Pages: 4167-4179
Published online: 28 May 2019
AbstractforRETRACTED ARTICLE: microRNA-612 suppresses the malignant development of non-small-cell lung cancer by directly targeting bromodomain-containing protein 4 | PDF (3.9 MB)
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Article
CD48 is a key molecule of immunomodulation affecting prognosis in glioma
Cunyi Zou, Chen Zhu, Gefei Guan, Qing Guo, Tianqi Liu, Shuai Shen, Zihao Yan, Xiaoyan Xu, Zhiguo Lin, Ling Chen, Anhua Wu & Wen Cheng
Pages: 4181-4193
Published online: 28 May 2019
AbstractforCD48 is a key molecule of immunomodulation affecting prognosis in glioma | Full Text | References | PDF (6.3 MB)
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Article
Evaluation of MET T1010I and MET rs40239 single-nucleotide polymorphisms in triple-negative breast cancer: a case–control study
Despoina Kalapanida, Flora Zagouri, Maria Gazouli, Andriani Tsiakou, Eleni Zografos, Constantine Dimitrakakis, Spyridon Marinopoulos, Aris Giannos, Theodoros N Sergentanis, Efstathios Kastritis, Evangelos Terpos & Meletios-Athanassios Dimopoulos
Pages: 4195-4202
Published online: 28 May 2019
AbstractforEvaluation of MET T1010I and MET rs40239 single-nucleotide polymorphisms in triple-negative breast cancer: a case–control study | Full Text | References | PDF (641.2 KB)
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Article
β-elemene inhibits radiation and hypoxia-induced macrophages infiltration via Prx-1/NF-κB/HIF-1α signaling pathway
Xiaomu Yu, Zongjuan Li, Yang Zhang, Maoyi Xu, Yilin Che, Xiaoyuan Tian, Ruonan Wang, Kun Zou & Lijuan Zou
Pages: 4203-4211
Published online: 28 May 2019
Abstractforβ-elemene inhibits radiation and hypoxia-induced macrophages infiltration via Prx-1/NF-κB/HIF-1α signaling pathway | Full Text | References | PDF (1.8 MB)
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Review

Review Article
NEDD9 overexpression predicts poor prognosis in solid cancers: a meta-analysis
Yang Gu, Jingjing Lu, Chen Chen & Fei Zheng
Pages: 4213-4222
Published online: 28 May 2019
AbstractforNEDD9 overexpression predicts poor prognosis in solid cancers: a meta-analysis | Full Text | References | PDF (1.8 MB)
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Corrigendum

Correction
CD40L inhibits cell growth of THP-1 cells by suppressing the PI3K/Akt pathway [Corrigendum]
Page: 4223
Published online: 28 May 2019
CitationforCD40L inhibits cell growth of THP-1 cells by suppressing the PI3K/Akt pathway [Corrigendum] | Full Text | PDF (147.5 KB)
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Original Research

Article
miR-29a inhibits proliferation, invasion, and migration of papillary thyroid cancer by targeting DPP4
Yufei Wang, Jie Han, Yuetao Lv & Guochao Zhang
Pages: 4225-4233
Published online: 28 May 2019
AbstractformiR-29a inhibits proliferation, invasion, and migration of papillary thyroid cancer by targeting DPP4 | Full Text | References | PDF (1.4 MB)
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Article
Neutrophil–lymphocyte ratio (NLR) predicted prognosis for advanced non-small-cell lung cancer (NSCLC) patients who received immune checkpoint blockade (ICB)
Fangping Ren, Tian Zhao, Bing Liu & Lei Pan
Pages: 4235-4244
Published online: 29 May 2019
AbstractforNeutrophil–lymphocyte ratio (NLR) predicted prognosis for advanced non-small-cell lung cancer (NSCLC) patients who received immune checkpoint blockade (ICB) | Full Text | References | PDF (1.7 MB)
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Article
Androgen receptor promotes oral squamous cell carcinoma cell migration by increasing EGFR phosphorylation
Xin Liu, Shanglan Qing, Keke Che, Lihua Li & Xiaoming Liao
Pages: 4245-4252
Published online: 04 Jun 2019
AbstractforAndrogen receptor promotes oral squamous cell carcinoma cell migration by increasing EGFR phosphorylation | Full Text | References | PDF (2.4 MB)
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Article
High LAMC1 expression in glioma is associated with poor prognosis
Jian Liu, Dingyang Liu, Zhuanyi Yang & Zhiquan Yang
Pages: 4253-4260
Published online: 29 May 2019
AbstractforHigh LAMC1 expression in glioma is associated with poor prognosis | Full Text | References | PDF (1.5 MB)
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Case Report

Case Report
Complete response to crizotinib in a metastatic adenocarcinoma of unknown primary harboring MET amplification and NTRK1 co-occurring mutation
Jing-hao Yao, An-sheng Wang, Xiao-jing Wang, Lu Zhang, Yue Zhu, Yu-rong Ou, Zi-shu Wang & Yan Yang
Pages: 4261-4267
Published online: 29 May 2019
AbstractforComplete response to crizotinib in a metastatic adenocarcinoma of unknown primary harboring MET amplification and NTRK1 co-occurring mutation | Full Text | References | PDF (2.1 MB)
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Original Research

Article
HnRNPL promotes Wilms tumor progression by regulating the p53 and Bcl2 pathways
Xin Luo, Changkai Deng, Feng Liu, Xing Liu, Tao Lin, Dawei He & Guanghui Wei
Pages: 4269-4279
Published online: 29 May 2019
AbstractforHnRNPL promotes Wilms tumor progression by regulating the p53 and Bcl2 pathways | Full Text | References | PDF (2 MB)
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Case Report

Case Report
Diagnosis and treatment of synchronous multiple primary lung cancer – a case report
Yi Bao, Jiayuan Wu, Jun Zhang & Yawei Yu
Pages: 4281-4285
Published online: 29 May 2019
AbstractforDiagnosis and treatment of synchronous multiple primary lung cancer – a case report | Full Text | References | PDF (1.2 MB)
  • 33 Views
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Original Research

Article
LncRNA FENDRR attenuates colon cancer progression by repression of SOX4 protein
Jianchao Liu & Wenfeng Du
Pages: 4287-4295
Published online: 30 May 2019
AbstractforLncRNA FENDRR attenuates colon cancer progression by repression of SOX4 protein | Full Text | References | PDF (2.2 MB)
  • 28 Views
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Article
SKP2 targeted inhibition suppresses human uveal melanoma progression by blocking ubiquitylation of p27
Hongbo Zhao, Hui Pan, Huixue Wang, Peiwei Chai, Shengfang Ge, Renbing Jia & Xianqun Fan
Pages: 4297-4308
Published online: 30 May 2019
AbstractforSKP2 targeted inhibition suppresses human uveal melanoma progression by blocking ubiquitylation of p27 | Full Text | References | PDF (1.4 MB)
  • 88 Views
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Article
Variability within the human TERT gene, telomere length and predisposition to chronic lymphocytic leukemia
Barbara Wysoczanska, Marta Dratwa, Katarzyna Gebura, Jakub Mizgala, Grzegorz Mazur, Tomasz Wrobel & Katarzyna Bogunia-Kubik
Pages: 4309-4320
Published online: 31 May 2019
AbstractforVariability within the human TERT gene, telomere length and predisposition to chronic lymphocytic leukemia | Full Text | References | PDF (1.3 MB)
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Retraction

Retraction
Polydatin exerts anti-tumor effects against renal cell carcinoma cells via induction of caspase-dependent apoptosis and inhibition of the PI3K/Akt pathway [Retraction]
Page: 4321
Published online: 04 Jun 2019
CitationforPolydatin exerts anti-tumor effects against renal cell carcinoma cells via induction of caspase-dependent apoptosis and inhibition of the PI3K/Akt pathway [Retraction] | Full Text | PDF (149.4 KB)
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Original Research

Article
Zoledronic acid exhibits radio-sensitizing activity in human pancreatic cancer cells via inactivation of STAT3/NF-κB signaling
Yanjie You, Qiang Wang, Haijun Li, Yuhong Ma, Yanhong Deng, Zhengcai Ye & Feihu Bai
Pages: 4323-4330
Published online: 04 Jun 2019
AbstractforZoledronic acid exhibits radio-sensitizing activity in human pancreatic cancer cells via inactivation of STAT3/NF-κB signaling | Full Text | References | PDF (1.9 MB)
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Article
Long intergenic noncoding RNA 00707 promotes colorectal cancer cell proliferation and metastasis by sponging miR-206
Huifang Zhu, Guoyang He, Yongqiang Wang, Yuhan Hu, Zheying Zhang, Xinlai Qian & Yongxia Wang
Pages: 4331-4340
Published online: 31 May 2019
AbstractforLong intergenic noncoding RNA 00707 promotes colorectal cancer cell proliferation and metastasis by sponging miR-206 | Full Text | References | PDF (658.3 KB)
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Article
Knockdown of cyclooxygenase-2 leads to growth inhibition and cell cycle arrest in hepatocellular carcinoma cells
Xiuhe Lv, Zhen Chen, Shaohua Li & Huahong Xie
Pages: 4341-4349
Published online: 31 May 2019
AbstractforKnockdown of cyclooxygenase-2 leads to growth inhibition and cell cycle arrest in hepatocellular carcinoma cells | Full Text | References | PDF (1.4 MB)
  • 33 Views
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Article
Diagnostic and prognostic roles of circ-SHPRH for solid cancers: a meta-analysis
Feng Li, Qilin Huang, Zhenyu Gong, Hongxiang Wang & Juxiang Chen
Pages: 4351-4357
Published online: 31 May 2019
AbstractforDiagnostic and prognostic roles of circ-SHPRH for solid cancers: a meta-analysis | Full Text | References | PDF (1.7 MB)
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Article
Deferoxamine-induced high expression of TfR1 and DMT1 enhanced iron uptake in triple-negative breast cancer cells by activating IL-6/PI3K/AKT pathway
Chunli Chen, Ping Liu, Xiaoyue Duan, Man Cheng & Lisa X Xu
Pages: 4359-4377
Published online: 31 May 2019
AbstractforDeferoxamine-induced high expression of TfR1 and DMT1 enhanced iron uptake in triple-negative breast cancer cells by activating IL-6/PI3K/AKT pathway | Full Text | References | PDF (9.1 MB)
  • 51 Views
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Article
High expression of GM II is associated with poor prognosis of gastric cancer patients
Shasha Zhu, Yao Li, Wei Xiao & Yaying Yang
Pages: 4379-4389
Published online: 04 Jun 2019
AbstractforHigh expression of GM II is associated with poor prognosis of gastric cancer patients | Full Text | References | PDF (2.1 MB)
  • 65 Views
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Article
m6A methyltransferase METTL3 suppresses colorectal cancer proliferation and migration through p38/ERK pathways
Ru Deng, Yikan Cheng, Shubiao Ye, Jianwei Zhang, Runqing Huang, Peisi Li, Huashan Liu, Qiling Deng, Xianrui Wu, Ping Lan & Yanhong Deng
Pages: 4391-4402
Published online: 04 Jun 2019
Abstractform6A methyltransferase METTL3 suppresses colorectal cancer proliferation and migration through p38/ERK pathways | Full Text | References | PDF (4.4 MB)
  • 56 Views
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Article
Norcantharidin inhibits the DDR of bladder cancer stem-like cells through cdc6 degradation
Xianghua Shi, Sansan Chen, Yongjun Zhang, Weiwei Xie, Zhiming Hu, Hongwei Li, Jinlong Li, Zhongxin Zhou & Wanlong Tan
Pages: 4403-4413
Published online: 07 Jun 2019
AbstractforNorcantharidin inhibits the DDR of bladder cancer stem-like cells through cdc6 degradation | Full Text | References | PDF (4 MB)
  • 84 Views
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Article
RETRACTED ARTICLE: MicroRNA-559 plays an inhibitory role in the malignant progression of glioblastoma cells by directly targeting metadherin
Fan Yang, Chuangang Zhang, Congbin Xu, Fangyou Fu, Dong Han & Hongliang Li
Pages: 4415-4426
Published online: 05 Jun 2019
AbstractforRETRACTED ARTICLE: MicroRNA-559 plays an inhibitory role in the malignant progression of glioblastoma cells by directly targeting metadherin | PDF (3.4 MB)
  • 10 Views
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Article
Licochalcone A inhibits cell proliferation, migration, and invasion through regulating the PI3K/AKT signaling pathway in oral squamous cell carcinoma
Yuli Hao, Chunping Zhang, Yuanyuan Sun & Hongyan Xu
Pages: 4427-4435
Published online: 05 Jun 2019
AbstractforLicochalcone A inhibits cell proliferation, migration, and invasion through regulating the PI3K/AKT signaling pathway in oral squamous cell carcinoma | Full Text | References | PDF (1.8 MB)
  • 103 Views
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Article
Sphingosine kinase 2 inhibitor ABC294640 displays anti-epithelial ovarian cancer activities in vitro and in vivo
Keqi Song, Lan Dai, Xiaoran Long, Xiaojuan Cui, Yixuan Liu & Wen Di
Pages: 4437-4449
Published online: 06 Jun 2019
AbstractforSphingosine kinase 2 inhibitor ABC294640 displays anti-epithelial ovarian cancer activities in vitro and in vivo | Full Text | References | PDF (3.7 MB)
  • 34 Views
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Article
Androgen upregulates the palmitoylation of eIF3L in human prostate LNCaP cells
Luwei Cui, Ming Liu, Shicong Lai, Huimin Hou, Tongxiang Diao, Dalei Zhang, Miao Wang, Yaoguang Zhang & Jianye Wang
Pages: 4451-4459
Published online: 05 Jun 2019
AbstractforAndrogen upregulates the palmitoylation of eIF3L in human prostate LNCaP cells | Full Text | References | PDF (1.9 MB)
  • 31 Views
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Article
The natural flavonoid glycoside vitexin displays preclinical antitumor activity by suppressing NF-κB signaling in nasopharyngeal carcinoma
Wenbin Wang, Hongbo Cheng, Xilan Gu & Xiaodong Yin
Pages: 4461-4468
Published online: 05 Jun 2019
AbstractforThe natural flavonoid glycoside vitexin displays preclinical antitumor activity by suppressing NF-κB signaling in nasopharyngeal carcinoma | Full Text | References | PDF (1.5 MB)
  • 124 Views
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Article
Long non-coding RNA FLJ33360 participates in ovarian cancer progression by sponging miR-30b-3p
Meiqin Yang, Zhensheng Zhai, Shuang Guo, Xiaoxi Li, Yongxia Zhu & Yue Wang
Pages: 4469-4480
Published online: 07 Jun 2019
AbstractforLong non-coding RNA FLJ33360 participates in ovarian cancer progression by sponging miR-30b-3p | Full Text | References | PDF (3.3 MB)
  • 77 Views
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Article
LINC00339 promotes growth and invasiveness of hepatocellular carcinoma by the miR-1182/SKA1 pathway
Jun Xiao, Haibo Yu & Zhongwu Ma
Pages: 4481-4488
Published online: 06 Jun 2019
AbstractforLINC00339 promotes growth and invasiveness of hepatocellular carcinoma by the miR-1182/SKA1 pathway | Full Text | References | PDF (2.3 MB)
  • 26 Views
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Article
A pooled analysis of transarterial radioembolization with yttrium-90 microspheres for the treatment of unresectable intrahepatic cholangiocarcinoma
Yanhua Zhen, Bin Liu, Zhihui Chang, Haiyan Ren, Zhaoyu Liu & Jiahe Zheng
Pages: 4489-4498
Published online: 07 Jun 2019
AbstractforA pooled analysis of transarterial radioembolization with yttrium-90 microspheres for the treatment of unresectable intrahepatic cholangiocarcinoma | Full Text | References | PDF (1.1 MB)
  • 16 Views
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Article
Ilex hainanensis Merr targets ITGAV to suppress the proliferation and metastasis of osteosarcoma cells
Yi Pei, YueYan Zhang, Ke Zheng, GuanNing Shang, YuMing Wang, Wei Wang, EnDuo Qiu, ShengLong Li, Fei Liu & XiaoJing Zhang
Pages: 4499-4507
Published online: 07 Jun 2019
AbstractforIlex hainanensis Merr targets ITGAV to suppress the proliferation and metastasis of osteosarcoma cells | Full Text | References | PDF (2.5 MB)
  • 17 Views
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Article
MiRNA-124 inhibits the proliferation, migration and invasion of cancer cell in hepatocellular carcinoma by downregulating lncRNA-UCA1
Baolei Zhao, Yanmin Lu, Xuefeng Cao, Wentao Zhu, Lingqun Kong, Haibin Ji, Fan Zhang, Xutao Lin, Qinghai Guan, Kun Ou, Xingyuan Zhang & Qiangpu Chen
Pages: 4509-4516
Published online: 12 Jun 2019
AbstractforMiRNA-124 inhibits the proliferation, migration and invasion of cancer cell in hepatocellular carcinoma by downregulating lncRNA-UCA1 | Full Text | References | PDF (1.7 MB)
  • 64 Views
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Article
Identification of candidate biomarkers correlated with the diagnosis and prognosis of cervical cancer via integrated bioinformatics analysis
Fangfang Dai, Gantao Chen, Yanqing Wang, Li Zhang, Youmei Long, Mengqin Yuan, Dongyong Yang, Shiyi Liu, Yanxiang Cheng & Liping Zhang
Pages: 4517-4532
Published online: 12 Jun 2019
AbstractforIdentification of candidate biomarkers correlated with the diagnosis and prognosis of cervical cancer via integrated bioinformatics analysis | Full Text | References | PDF (5.9 MB)
  • 78 Views
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Article
KIF5B-RET fusion gene and its correlation with clinicopathological and prognostic features in lung cancer: a meta-analysis
Xiao-Feng Cong, Lei Yang, Chen Chen & Ziling Liu
Pages: 4533-4542
Published online: 11 Jun 2019
AbstractforKIF5B-RET fusion gene and its correlation with clinicopathological and prognostic features in lung cancer: a meta-analysis | Full Text | References | PDF (879.3 KB)
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Review

Review Article
Evaluating tisagenlecleucel and its potential in the treatment of relapsed or refractory diffuse large B cell lymphoma: evidence to date
PD Zavras, Y Wang, A Gandhi, K Lontos & GM Delgoffe
Pages: 4543-4554
Published online: 11 Jun 2019
AbstractforEvaluating tisagenlecleucel and its potential in the treatment of relapsed or refractory diffuse large B cell lymphoma: evidence to date | Full Text | References | PDF (562.9 KB)
  • 124 Views
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Original Research

Article
Pseudogene DUXAP10 acts as a diagnostic and prognostic marker and promotes cell proliferation by activating PI3K/AKT pathway in hepatocellular carcinoma
Chaosen Yue, Chaojie Liang, Hua Ge, Lijun Yan, Yingchen Xu, Guangming Li, Pengyang Li, Zhigang Wei & Jixiang Wu
Pages: 4555-4566
Published online: 11 Jun 2019
AbstractforPseudogene DUXAP10 acts as a diagnostic and prognostic marker and promotes cell proliferation by activating PI3K/AKT pathway in hepatocellular carcinoma | Full Text | References | PDF (2.4 MB)
  • 60 Views
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Review

Review Article
Profile of alectinib for the treatment of ALK-positive non-small cell lung cancer (NSCLC): patient selection and perspectives
Niki Karachaliou, Manuel Fernandez Bruno, Jillian Wilhelmina Paulina Bracht & Rafael Rosell
Pages: 4567-4575
Published online: 13 Jun 2019
AbstractforProfile of alectinib for the treatment of ALK-positive non-small cell lung cancer (NSCLC): patient selection and perspectives | Full Text | References | PDF (363.5 KB)
  • 205 Views
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Case Report

Article
Probe-based confocal laser endomicroscopy (pCLE) is a suitable method for extrapulmonary high grade neuroendocrine rectal carcinoma (HGNEC) evaluation
Renato Cannizzaro, Stefania Maiero, Mara Fornasarig, Vincenzo Canzonieri, Raffaella Magris, Giovanni Guarnieri, Martina Urbani, Angela Buonadonna, Tanja Baresic & Paola Spessotto
Pages: 4577-4583
Published online: 17 Jun 2019
AbstractforProbe-based confocal laser endomicroscopy (pCLE) is a suitable method for extrapulmonary high grade neuroendocrine rectal carcinoma (HGNEC) evaluation | Full Text | References | PDF (2.8 MB)
  • 63 Views
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Original Research

Article
Harmine suppresses the proliferation of pancreatic cancer cells and sensitizes pancreatic cancer to gemcitabine treatment
Lin-Wen Wu, Jian-Kang Zhang, Mingjun Rao, Zuo-Yan Zhang, Hua-Jian Zhu & Chong Zhang
Pages: 4585-4593
Published online: 12 Jun 2019
AbstractforHarmine suppresses the proliferation of pancreatic cancer cells and sensitizes pancreatic cancer to gemcitabine treatment | Full Text | References | PDF (2.2 MB)
  • 147 Views
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Article
Downregulation of microRNA-4324 promotes the EMT of esophageal squamous-cell carcinoma cells via upregulating FAK
Jian Zhou, Jiangtao Zhu, Guojun Jiang, Juncheng Feng & Qianqian Wang
Pages: 4595-4604
Published online: 12 Jun 2019
AbstractforDownregulation of microRNA-4324 promotes the EMT of esophageal squamous-cell carcinoma cells via upregulating FAK | Full Text | References | PDF (2.4 MB)
  • 22 Views
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Review

Article
Immune checkpoint inhibitors for small cell lung cancer: opportunities and challenges
Orgilmaa Regzedmaa, Hongbing Zhang, Hongyu Liu & Jun Chen
Pages: 4605-4620
Published online: 13 Jun 2019
AbstractforImmune checkpoint inhibitors for small cell lung cancer: opportunities and challenges | Full Text | References | PDF (1.1 MB)
  • 140 Views
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Original Research

Article
Overexpression of microRNA-216a inhibits autophagy by targeting regulated MAP1S in colorectal cancer
Yunfeng Wang, Songyan Zhang, Shuwei Dang, Xuan Fang & Ming Liu
Pages: 4621-4629
Published online: 12 Jun 2019
AbstractforOverexpression of microRNA-216a inhibits autophagy by targeting regulated MAP1S in colorectal cancer | Full Text | References | PDF (1.8 MB)
  • 69 Views
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Article
Association between potentially functional polymorphisms of chemokine family members and the survival of esophageal cancer patients in a Chinese population
Jin-Lin Du, Ge-Nan Li, Rong-Wei He, Shi-Zhuo Zhang, Xing Zhang & Zhi-Gang Huang
Pages: 4631-4641
Published online: 13 Jun 2019
AbstractforAssociation between potentially functional polymorphisms of chemokine family members and the survival of esophageal cancer patients in a Chinese population | Full Text | References | PDF (1.3 MB)
  • 19 Views
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Article
Rapamycin suppresses angiogenesis and lymphangiogenesis in melanoma by downregulating VEGF-A/VEGFR-2 and VEGF-C/VEGFR-3 expression
Min Wang, Yuan Xu, Guo-Zhong Wen, Qian Wang & Si-Ming Yuan
Pages: 4643-4654
Published online: 13 Jun 2019
AbstractforRapamycin suppresses angiogenesis and lymphangiogenesis in melanoma by downregulating VEGF-A/VEGFR-2 and VEGF-C/VEGFR-3 expression | Full Text | References | PDF (4.2 MB)
  • 37 Views
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Article
Studies on the treatment of melanoma with folate acid conjugated dextran and lauryl alcohol loaded with IMD0354
Can Liu, Wei Chen, Zizi Chen, Yu Yan, Qing Wang, Huiqing Xie, Xiang Chen, Aijun Wang, Shijie Tang & Jianda Zhou
Pages: 4655-4663
Published online: 14 Jun 2019
AbstractforStudies on the treatment of melanoma with folate acid conjugated dextran and lauryl alcohol loaded with IMD0354 | Full Text | References | PDF (1.8 MB)
  • 59 Views
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Corrigendum

Correction
Grape seed procyanidin B2 promotes the autophagy and apoptosis in colorectal cancer cells via regulating PI3K/Akt signaling pathway [Corrigendum]
Page: 4665
Published online: 14 Jun 2019
CitationforGrape seed procyanidin B2 promotes the autophagy and apoptosis in colorectal cancer cells via regulating PI3K/Akt signaling pathway [Corrigendum] | Full Text | PDF (145.9 KB)
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Original Research

Article
Effect of overexpression of Oct4 and Sox2 genes on the biological and oncological characteristics of gastric cancer cells
Borong Chen, Zhipeng Zhu, Lulu Li, Weipeng Ye, Junjie Zeng, Jin Gao, Shengjie Wang, Liang Zhang & Zhengjie Huang
Pages: 4667-4682
Published online: 18 Jun 2019
AbstractforEffect of overexpression of Oct4 and Sox2 genes on the biological and oncological characteristics of gastric cancer cells | Full Text | References | PDF (5.9 MB)
  • 148 Views
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Article
WHSC1 acts as a prognostic indicator and functions as an oncogene in cervical cancer
Jin Wu, Ming Luo, Zhaoning Duan, Ying Jia, Hua Linghu, Pu Tian & Hongbo Qi
Pages: 4683-4690
Published online: 17 Jun 2019
AbstractforWHSC1 acts as a prognostic indicator and functions as an oncogene in cervical cancer | Full Text | References | PDF (2 MB)
  • 28 Views
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Article
Effects of BCc1 nanoparticle and its mixture with doxorubicin on survival of murine 4T1 tumor model
Maryam Hafizi, Masoud Soleimani, Sajad Noorian, Somayeh Kalanaky, Saideh Fakharzadeh, Nafiseh Tavakolpoor Saleh, Mohammad Hassan Nazaran & Mohammad Esmaeil Akbari
Pages: 4691-4701
Published online: 18 Jun 2019
AbstractforEffects of BCc1 nanoparticle and its mixture with doxorubicin on survival of murine 4T1 tumor model | Full Text | References | PDF (1.9 MB)
  • 49 Views
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Article
Overexpression of CD55 correlates with tumor progression and poor prognosis in gastric stromal tumors
Xiaonan Yin, Chaoyong Shen, Yuan Yin, Zhaolun Cai, Jian Wang, Zhou Zhao, Xin Chen, Zhixin Chen, Huijiao Chen & Bo Zhang
Pages: 4703-4712
Published online: 18 Jun 2019
AbstractforOverexpression of CD55 correlates with tumor progression and poor prognosis in gastric stromal tumors | Full Text | References | PDF (1.1 MB)
  • 81 Views
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Article
Effect of the imatinib treatment regimen on the postoperative prognosis of patients with high-risk gastrointestinal stromal tumors
Yan-Shu Li, Wei Li, Qing-Sheng Zeng & Wei-Hua Fu
Pages: 4713-4719
Published online: 18 Jun 2019
AbstractforEffect of the imatinib treatment regimen on the postoperative prognosis of patients with high-risk gastrointestinal stromal tumors | Full Text | References | PDF (448.6 KB)
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Review

Review Article
Oral microbiota and gastrointestinal cancer
Yangyang Zhang, Qiaoli Niu, Wenguo Fan, Fang Huang & Hongwen He
Pages: 4721-4728
Published online: 18 Jun 2019
AbstractforOral microbiota and gastrointestinal cancer | Full Text | References | PDF (723.2 KB)
  • 59 Views
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Original Research

Article
Long noncoding RNA LINC-PINT promotes proliferation through EZH2 and predicts poor prognosis in clear cell renal cell carcinoma
Junyao Duan, Xin Ma, Jing Shi, Yundong Xuan, Hanfeng Wang, Pin Li, Yu Zhang, Yang Fan, Huijie Gong, Xuetao Ma, Yuewen Pang, Ling Wang, Yongji Yan & Xu Zhang
Pages: 4729-4740
Published online: 19 Jun 2019
AbstractforLong noncoding RNA LINC-PINT promotes proliferation through EZH2 and predicts poor prognosis in clear cell renal cell carcinoma | Full Text | References | PDF (3.5 MB)
  • 67 Views
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Article
Intramedullary spinal cord metastasis in malignancies: an institutional analysis and review
Jincai Lv, Bailong Liu, Xiaoyue Quan, Cheng Li, Lihua Dong & Min Liu
Pages: 4741-4753
Published online: 21 Jun 2019
AbstractforIntramedullary spinal cord metastasis in malignancies: an institutional analysis and review | Full Text | References | PDF (1.2 MB)
  • 51 Views
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Article
Decreased expression of SPINT1-AS1 and SPINT1 mRNA might be independent unfavorable prognostic indicators in esophageal squamous cell carcinoma
Fang-Fang Shen, Ying Pan, Hai-Jun Yang, Jun-Kuo Li, Fang Zhao, Jing-Fen Su, Yan-Yan Li, Lin-Qiang Tian, Pan-Ting Yu, Yan-Tian Cao, Yao-Wen Zhang & Fu-You Zhou
Pages: 4755-4763
Published online: 20 Jun 2019
AbstractforDecreased expression of SPINT1-AS1 and SPINT1 mRNA might be independent unfavorable prognostic indicators in esophageal squamous cell carcinoma | Full Text | References | PDF (901.2 KB)
  • 68 Views
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Review

Review Article
Emerging roles of circular RNAs in colorectal cancer
Shuhong Hao, Liang Cong, Rongfeng Qu, Rui Liu, Guizhen Zhang & Yarong Li
Pages: 4765-4777
Published online: 19 Jun 2019
AbstractforEmerging roles of circular RNAs in colorectal cancer | Full Text | References | PDF (798.8 KB)
  • 120 Views
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Original Research

Article
Downregulation of H19 decreases the radioresistance in esophageal squamous cell carcinoma cells
Wenguang Luo, Wei Liu, Jie Yao, Wenjing Zhu, Hongyan Zhang, Qi Sheng, Lin Wang, Lei Lv & Liting Qian
Pages: 4779-4788
Published online: 19 Jun 2019
AbstractforDownregulation of H19 decreases the radioresistance in esophageal squamous cell carcinoma cells | Full Text | References | PDF (1.8 MB)
  • 84 Views
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Article
SOX30 methylation correlates with disease progression in patients with chronic myeloid leukemia
Ting-Juan Zhang, Xiang-Mei Wen, Jing-Dong Zhou, Yu Gu, Zi-Jun Xu, Hong Guo, Ji-Chun Ma, Qian Yuan, Qin Chen, Jiang Lin & Jun Qian
Pages: 4789-4794
Published online: 20 Jun 2019
AbstractforSOX30 methylation correlates with disease progression in patients with chronic myeloid leukemia | Full Text | References | PDF (1.1 MB)
  • 61 Views
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Article
RETRACTED ARTICLE: Upregulated RACK1 attenuates gastric cancer cell growth and epithelial–mesenchymal transition via suppressing Wnt/β-catenin signaling
Lihui Zhu, Wen Chen, Guoqing Li, Honghui Chen, Wenqiu Liao, Li Zhang & Xiaoli Xiao
Pages: 4795-4805
Published online: 20 Jun 2019
AbstractforRETRACTED ARTICLE: Upregulated RACK1 attenuates gastric cancer cell growth and epithelial–mesenchymal transition via suppressing Wnt/β-catenin signaling | PDF (4.2 MB)
  • 19 Views
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Case Report

Case Report
BRAF V600E-positive monomorphic epitheliotropic intestinal T-cell lymphoma complicating the course of hairy cell leukemia
Alessandro Broccoli, Clara Bertuzzi, Michelangelo Fiorentino, Alice Morigi, Vittorio Stefoni, Claudio Agostinelli, Lisa Argnani, Michele Cavo & Pier Luigi Zinzani
Pages: 4807-4812
Published online: 20 Jun 2019
AbstractforBRAF V600E-positive monomorphic epitheliotropic intestinal T-cell lymphoma complicating the course of hairy cell leukemia | Full Text | References | PDF (2.2 MB)
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Original Research

Article
RETRACTED ARTICLE: MicroRNA-937 inhibits the malignant phenotypes of breast cancer by directly targeting and downregulating forkhead box Q1
Xiaoting Han, Xiaolong Guo, Wenzhen Zhang & Qiumei Cong
Pages: 4813-4824
Published online: 20 Jun 2019
AbstractforRETRACTED ARTICLE: MicroRNA-937 inhibits the malignant phenotypes of breast cancer by directly targeting and downregulating forkhead box Q1 | PDF (3 MB)
  • 16 Views
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Article
Abietic acid suppresses non-small-cell lung cancer cell growth via blocking IKKβ/NF-κB signaling
Xueping Liu, Wei Chen, Quanxing Liu & Jigang Dai
Pages: 4825-4837
Published online: 20 Jun 2019
AbstractforAbietic acid suppresses non-small-cell lung cancer cell growth via blocking IKKβ/NF-κB signaling | Full Text | References | PDF (3.5 MB)
  • 188 Views
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Article
Upregulation of microRNA-1270 suppressed human glioblastoma cancer cell proliferation migration and tumorigenesis by acting through WT1
Lai Wei, Pan Li, Chunjing Zhao, Na Wang & Na Wei
Pages: 4839-4848
Published online: 20 Jun 2019
AbstractforUpregulation of microRNA-1270 suppressed human glioblastoma cancer cell proliferation migration and tumorigenesis by acting through WT1 | Full Text | References | PDF (1.3 MB)
  • 33 Views
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Article
Retrospective study of the efficacy and toxicity of lobaplatin in combined chemotherapy for metastatic breast cancer
Yuan Wu, Xiao-Yue Xu, Fei Yan, Wei-Li Sun, Yan Zhang, De-Lin Liu & Bo Shen
Pages: 4849-4857
Published online: 21 Jun 2019
AbstractforRetrospective study of the efficacy and toxicity of lobaplatin in combined chemotherapy for metastatic breast cancer | Full Text | References | PDF (1,004.9 KB)
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Review

Review Article
Prolonged low-dose infusion for gemcitabine: a systematic review
Dehua Zhao, Jing Chen, Mingming Chu & Jisheng Wang
Pages: 4859-4868
Published online: 21 Jun 2019
AbstractforProlonged low-dose infusion for gemcitabine: a systematic review | Full Text | References | PDF (527.1 KB)
  • 80 Views
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Original Research

Article
RETRACTED ARTICLE: microRNA-564 inhibits the aggressive phenotypes of papillary thyroid cancer by directly targeting astrocyte-elevated gene-1
Zhenzhen Song, Huimei Yang, Xia Wu, Cui Kong & Cong’e Xu
Pages: 4869-4881
Published online: 28 Jun 2019
AbstractforRETRACTED ARTICLE: microRNA-564 inhibits the aggressive phenotypes of papillary thyroid cancer by directly targeting astrocyte-elevated gene-1 | PDF (4.1 MB)
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Article
Long noncoding RNA LINC01089 predicts clinical prognosis and inhibits cell proliferation and invasion through the Wnt/β-catenin signaling pathway in breast cancer
Hongfan Yuan, Yi Qin, Beilei Zeng, Yixiao Feng, Yunhai Li, Tingxiu Xiang & Guosheng Ren
Pages: 4883-4895
Published online: 21 Jun 2019
AbstractforLong noncoding RNA LINC01089 predicts clinical prognosis and inhibits cell proliferation and invasion through the Wnt/β-catenin signaling pathway in breast cancer | Full Text | References | PDF (3.9 MB)
  • 83 Views
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Article
miR-3691-5p promotes hepatocellular carcinoma cell migration and invasion through activating PI3K/Akt signaling by targeting PTEN
Wei Du, Xu Zhang & Zhen Wan
Pages: 4897-4906
Published online: 21 Jun 2019
AbstractformiR-3691-5p promotes hepatocellular carcinoma cell migration and invasion through activating PI3K/Akt signaling by targeting PTEN | Full Text | References | PDF (2.5 MB)
  • 66 Views
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Article
IFN-γ and TNF-α aggravate endothelial damage caused by CD123-targeted CAR T cell
Yao Sun, Shenyu Wang, Long Zhao, Bin Zhang & Hu Chen
Pages: 4907-4925
Published online: 24 Jun 2019
AbstractforIFN-γ and TNF-α aggravate endothelial damage caused by CD123-targeted CAR T cell | Full Text | References | PDF (6.5 MB)
  • 55 Views
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Article
miR-373 promotes neuroblastoma cell proliferation, migration, and invasion by targeting SRCIN1
Xiu-Li Yuan, Fei-Qiu Wen, Xiao-Wen Chen, Xian-Ping Jiang & Si-Xi Liu
Pages: 4927-4936
Published online: 21 Jun 2019
AbstractformiR-373 promotes neuroblastoma cell proliferation, migration, and invasion by targeting SRCIN1 | Full Text | References | PDF (3.3 MB)
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Review

Review Article
Dissecting the prevention of estrogen-dependent breast carcinogenesis through Nrf2-dependent and independent mechanisms
Aldo Giudice, Antonio Barbieri, Sabrina Bimonte, Marco Cascella, Arturo Cuomo, Anna Crispo, Giovanni D'Arena, Massimiliano Galdiero, Maria Elena Della Pepa, Gerardo Botti, Michele Caraglia, Mario Capunzo, Claudio Arra & Maurizio Montella
Pages: 4937-4953
Published online: 24 Jun 2019
AbstractforDissecting the prevention of estrogen-dependent breast carcinogenesis through Nrf2-dependent and independent mechanisms | Full Text | References | PDF (1.1 MB)
  • 130 Views
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Review Article
A pooled meta-analysis of PD-1/L1 inhibitors incorporation therapy for advanced non-small cell lung cancer
Ning Wan, Bo Ji, Jian Li, Jie Jiang, Chen Yang, Tiantian Zhang & Wenjie Huang
Pages: 4955-4973
Published online: 27 Jun 2019
AbstractforA pooled meta-analysis of PD-1/L1 inhibitors incorporation therapy for advanced non-small cell lung cancer | Full Text | References | PDF (4.6 MB)
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Original Research

Article
TRIM11 promotes proliferation and glycolysis of breast cancer cells via targeting AKT/GLUT1 pathway
WenBo Song, Zheng Wang, Xiang Gu, ALi Wang, XiaoJun Chen, Hui Miao, JunFeng Chu & Ye Tian
Pages: 4975-4984
Published online: 28 Jun 2019
AbstractforTRIM11 promotes proliferation and glycolysis of breast cancer cells via targeting AKT/GLUT1 pathway | Full Text | References | PDF (2.4 MB)
  • 37 Views
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Article
CXCR4 antagonism in combination with IDO1 inhibition weakens immune suppression and inhibits tumor growth in mouse breast cancer bone metastases
Jian Zhang, Yanxia Pang, Tao Xie & Liulong Zhu
Pages: 4985-4992
Published online: 28 Jun 2019
AbstractforCXCR4 antagonism in combination with IDO1 inhibition weakens immune suppression and inhibits tumor growth in mouse breast cancer bone metastases | Full Text | References | PDF (2 MB)
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Article
The role of miR-382-5p in glioma cell proliferation, migration and invasion
Jinjin Wang, Chunfeng Chen, Xu Yan & Peng Wang
Pages: 4993-5002
Published online: 25 Jun 2019
AbstractforThe role of miR-382-5p in glioma cell proliferation, migration and invasion | Full Text | References | PDF (3.7 MB)
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Article
ARHGAP4 mediates the Warburg effect in pancreatic cancer through the mTOR and HIF-1α signaling pathways
Yehua Shen, Gang Chen, Liping Zhuang, Litao Xu, Junhua Lin & Luming Liu
Pages: 5003-5012
Published online: 28 Jun 2019
AbstractforARHGAP4 mediates the Warburg effect in pancreatic cancer through the mTOR and HIF-1α signaling pathways | Full Text | References | PDF (2.8 MB)
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Article
Clinical efficacy of decitabine in combination with standard-dose cytarabine, aclarubicin hydrochloride, and granulocyte colony-stimulating factor in the treatment of young patients with newly diagnosed acute myeloid leukemia
Liping Dou, Qingyu Xu, Mengzhen Wang, Yang Xiao, Longcan Cheng, Honghua Li, Wenrong Huang, Junhui Mei, Yu Jing, Jian Bo, Daihong Liu & Li Yu
Pages: 5013-5023
Published online: 28 Jun 2019
AbstractforClinical efficacy of decitabine in combination with standard-dose cytarabine, aclarubicin hydrochloride, and granulocyte colony-stimulating factor in the treatment of young patients with newly diagnosed acute myeloid leukemia | Full Text | References | PDF (1.6 MB)
  • 34 Views
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Article
Cyclin-dependent kinase inhibitor 2B gene is associated with the sensitivity of hepatoma cells to Sorafenib
Xie Weng, Lixian Zeng, Feifei Yan, Mengxue He, Xiuqiong Wu & Dayong Zheng
Pages: 5025-5036
Published online: 28 Jun 2019
AbstractforCyclin-dependent kinase inhibitor 2B gene is associated with the sensitivity of hepatoma cells to Sorafenib | Full Text | References | PDF (3.9 MB)
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Article
PRPF40A as a potential diagnostic and prognostic marker is upregulated in pancreatic cancer tissues and cell lines: an integrated bioinformatics data analysis
Zhen Huo, Shuyu Zhai, Yuanchi Weng, Hao Qian, Xiaomei Tang, Yusheng Shi, Xiaxing Deng, Yue Wang & Baiyong Shen
Pages: 5037-5051
Published online: 28 Jun 2019
AbstractforPRPF40A as a potential diagnostic and prognostic marker is upregulated in pancreatic cancer tissues and cell lines: an integrated bioinformatics data analysis | Full Text | References | PDF (4.6 MB)
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Article
Monoclonal antibody AC10364 inhibits cell proliferation in 5-fluorouracil resistant hepatocellular carcinoma via apoptotic pathways
Jianzhong Wu, Junwei Qu, Haixia Cao, Changwen Jing, Zhuo Wang, Heng Xu & Rong Ma
Pages: 5053-5067
Published online: 28 Jun 2019
AbstractforMonoclonal antibody AC10364 inhibits cell proliferation in 5-fluorouracil resistant hepatocellular carcinoma via apoptotic pathways | Full Text | References | PDF (4.1 MB)
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Article
Overexpression of miR-450 affects the biological behavior of HepG2 cells by targeting DNMT3a
Yan Wang, Lina Wang, Xue Yu & Jianping Duan
Pages: 5069-5076
Published online: 01 Jul 2019
AbstractforOverexpression of miR-450 affects the biological behavior of HepG2 cells by targeting DNMT3a | Full Text | References | PDF (1.8 MB)
  • 27 Views
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Article
Preparation of highly activated natural killer cells for advanced lung cancer therapy
Silun Xie, Zhenyi Wu, Lizhi Niu, Jibing Chen, Yunkun Ma & Mingjie Zhang
Pages: 5077-5086
Published online: 01 Jul 2019
AbstractforPreparation of highly activated natural killer cells for advanced lung cancer therapy | Full Text | References | PDF (761.6 KB)
  • 53 Views
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Article
Dietary natural astaxanthin at an early stage inhibits N-nitrosomethylbenzylamine–induced esophageal cancer oxidative stress and inflammation via downregulation of NFκB and COX2 in F344 rats
Lingling Cui, Fan Xu, Minkai Wang, Li Li, Tianyi Qiao, Han Cui, Zhonglei Li & Changqing Sun
Pages: 5087-5096
Published online: 01 Jul 2019
AbstractforDietary natural astaxanthin at an early stage inhibits N-nitrosomethylbenzylamine–induced esophageal cancer oxidative stress and inflammation via downregulation of NFκB and COX2 in F344 rats | Full Text | References | PDF (1.5 MB)
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Review

Review Article
Update on liquid biopsy in clinical management of non-small cell lung cancer
Zhen Wu, Zhen Yang, Yu Dai, Qiang Zhu & Liang-An Chen
Pages: 5097-5109
Published online: 01 Jul 2019
AbstractforUpdate on liquid biopsy in clinical management of non-small cell lung cancer | Full Text | References | PDF (343.4 KB)
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Original Research

Article
RETRACTED ARTICLE: Dihydrotanshinone I inhibits the growth of osteosarcoma through the Wnt/β-catenin signaling pathway
Tao Tan, Jin Chen, Yaxin Hu, Nan Wang, Yangmei Chen, Tingting Yu, Duanyang Lin, Shengdong Yang, Jinyong Luo & Xiaoji Luo
Pages: 5111-5122
Published online: 02 Jul 2019
AbstractforRETRACTED ARTICLE: Dihydrotanshinone I inhibits the growth of osteosarcoma through the Wnt/β-catenin signaling pathway | PDF (5 MB)
  • 56 Views
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Review

Review Article
Targeted therapy and personalized medicine in gastrointestinal stromal tumors: drug resistance, mechanisms, and treatment strategies
George Z Li & Chandrajit P Raut
Pages: 5123-5133
Published online: 01 Jul 2019
AbstractforTargeted therapy and personalized medicine in gastrointestinal stromal tumors: drug resistance, mechanisms, and treatment strategies | Full Text | References | PDF (1.5 MB)
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Original Research

Article
The safety and efficacy of amrubicin in the treatment of previously untreated extensive-disease small-cell lung cancer: a meta-analysis
Ji-Feng Wu, Jian-Jun Zhou, Xin-Ai Li, Li-Hui Hu & Meng-Li Wen
Pages: 5135-5142
Published online: 01 Jul 2019
AbstractforThe safety and efficacy of amrubicin in the treatment of previously untreated extensive-disease small-cell lung cancer: a meta-analysis | Full Text | References | PDF (1.6 MB)
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Article
MTSS1 inhibits metastatic potential and induces G2/M phase cell cycle arrest in gastric cancer
Ke Liu, Xiao-Dong Jiao, Jie-Lu Hao, Bao-Dong Qin, Ying Wu, Wei Chen, Jun Liu, Xi He & Yuan-Sheng Zang
Pages: 5143-5152
Published online: 02 Jul 2019
AbstractforMTSS1 inhibits metastatic potential and induces G2/M phase cell cycle arrest in gastric cancer | Full Text | References | PDF (2 MB)
  • 25 Views
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Article
Bioinformatics analysis of molecular genetic targets and key pathways for hepatocellular carcinoma
Junxue Tu, Jingjing Chen, Meimei He, Hongfei Tong, Haibin Liu, Bin Zhou, Yi Liao & Zhaohong Wang
Pages: 5153-5162
Published online: 02 Jul 2019
AbstractforBioinformatics analysis of molecular genetic targets and key pathways for hepatocellular carcinoma | Full Text | References | PDF (3.5 MB)
  • 65 Views
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Article
Dehydrocorydaline inhibits cell proliferation, migration and invasion via suppressing MEK1/2-ERK1/2 cascade in melanoma
Huanrong Hu, Zhen Dong, Xianxing Wang, Longchang Bai, Qian Lei, Jie Yang, Lin Li, Qian Li, Lichao Liu, Yanli Zhang, Yacong Ji, Leiyang Guo, Yaling Liu & Hongjuan Cui
Pages: 5163-5175
Published online: 02 Jul 2019
AbstractforDehydrocorydaline inhibits cell proliferation, migration and invasion via suppressing MEK1/2-ERK1/2 cascade in melanoma | Full Text | References | PDF (4.1 MB)
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Review

Review Article
Evidence to date: talazoparib in the treatment of breast cancer
Pedro Exman, Romualdo Barroso-Sousa & Sara M Tolaney
Pages: 5177-5187
Published online: 02 Jul 2019
AbstractforEvidence to date: talazoparib in the treatment of breast cancer | Full Text | References | PDF (286.7 KB)
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Original Research

Article
RETRACTED ARTICLE: C-terminal of E1A binding protein 1 enhances the migration of gastric epithelial cells and has a clinicopathologic significance in human gastric carcinoma
Can Wang, Min Wang, Bocheng Xing, Zhaocheng Chi, Hongyu Wang, Chunxiao Lie & Han Dong
Pages: 5189-5200
Published online: 02 Jul 2019
AbstractforRETRACTED ARTICLE: C-terminal of E1A binding protein 1 enhances the migration of gastric epithelial cells and has a clinicopathologic significance in human gastric carcinoma | PDF (2 MB)
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Article
Prognostic value of aspartate transaminase to alanine transaminase (De Ritis) ratio in solid tumors: a pooled analysis of 9,400 patients
Jiayuan Wu, Lin Chen, Yufeng Wang, Wenkai Tan & Zhe Huang
Pages: 5201-5213
Published online: 02 Jul 2019
AbstractforPrognostic value of aspartate transaminase to alanine transaminase (De Ritis) ratio in solid tumors: a pooled analysis of 9,400 patients | Full Text | References | PDF (2.1 MB)
  • 58 Views
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Article
LSD1 regulates Notch and PI3K/Akt/mTOR pathways through binding the promoter regions of Notch target genes in esophageal squamous cell carcinoma
Guiqin Hou, Qi Zhao, Mengying Zhang, Peng Wang, Hua Ye, Yang Wang, Yandan Ren, Jianying Zhang & Zhaoming Lu
Pages: 5215-5225
Published online: 02 Jul 2019
AbstractforLSD1 regulates Notch and PI3K/Akt/mTOR pathways through binding the promoter regions of Notch target genes in esophageal squamous cell carcinoma | Full Text | References | PDF (2.7 MB)
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Article
Ethyl acetate extracts of Nepenthes ventricosa x sibuyanensis leaves cause growth inhibition against oral cancer cells via oxidative stress
Jen-Yang Tang, Tzu-Jung Yu, Li-Ching Lin, Sheng-Yao Peng, Chun-Lin Wang, Fu Ou-Yang, Yuan-Bin Cheng & Hsueh-Wei Chang
Pages: 5227-5239
Published online: 03 Jul 2019
AbstractforEthyl acetate extracts of Nepenthes ventricosa x sibuyanensis leaves cause growth inhibition against oral cancer cells via oxidative stress | Full Text | References | PDF (3.9 MB)
  • 46 Views
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Article
Albumin-to-alkaline phosphatase ratio at diagnosis predicts survival in patients with metastatic non-small-cell lung cancer
Dan Li, He Yu & Weimin Li
Pages: 5241-5249
Published online: 02 Jul 2019
AbstractforAlbumin-to-alkaline phosphatase ratio at diagnosis predicts survival in patients with metastatic non-small-cell lung cancer | Full Text | References | PDF (1.2 MB)
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Case Report

Case Report
Effective high intensity focused ultrasound treatment in recurrent aggressive breast fibromatosis: a case report
Jing Zhao, Qiyuan Wang, Xiuzhen Li, Xiaoye Hu & Hong Shen
Pages: 5251-5256
Published online: 02 Jul 2019
AbstractforEffective high intensity focused ultrasound treatment in recurrent aggressive breast fibromatosis: a case report | Full Text | References | PDF (1.6 MB)
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Review

Review Article
Animal models of well-differentiated/dedifferentiated liposarcoma: utility and limitations
Silvia Codenotti, Walaa Mansoury, Luca Pinardi, Eugenio Monti, Francesco Marampon & Alessandro Fanzani
Pages: 5257-5268
Published online: 03 Jul 2019
AbstractforAnimal models of well-differentiated/dedifferentiated liposarcoma: utility and limitations | Full Text | References | PDF (1.1 MB)
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Original Research

Article
Helicobacter pylori upregulates TRPC6 via Wnt/β-catenin signaling to promote gastric cancer migration and invasion
Yang Song, Gao Liu, Shuang Liu, Rong Chen, Na Wang, Zhaoyu Liu, Xiao Zhang, Zheng Xiao & Lin Liu
Pages: 5269-5279
Published online: 03 Jul 2019
AbstractforHelicobacter pylori upregulates TRPC6 via Wnt/β-catenin signaling to promote gastric cancer migration and invasion | Full Text | References | PDF (3.1 MB)
  • 33 Views
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Article
Rhein sensitizes human colorectal cancer cells to EGFR inhibitors by inhibiting STAT3 pathway
Yan Zhuang, Ying Bai, Yan Hu, Yueqin Guo, Lingyuan Xu, Wanle Hu, Lehe Yang, Chengguang Zhao, Xiaokun Li & Haiyang Zhao
Pages: 5281-5291
Published online: 03 Jul 2019
AbstractforRhein sensitizes human colorectal cancer cells to EGFR inhibitors by inhibiting STAT3 pathway | Full Text | References | PDF (4.3 MB)
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Case Series

Article
Completely resolved advanced biliary tract cancer after treatment by pembrolizumab: a report of two cases
Osama M Alshari, Tamara A Dawaymeh, Nour A Tashtush, Abdelwahab J Aleshawi, Abdel Rahman A Al Manasra & Khaled A Obeidat
Pages: 5293-5298
Published online: 04 Jul 2019
AbstractforCompletely resolved advanced biliary tract cancer after treatment by pembrolizumab: a report of two cases | Full Text | References | PDF (924.3 KB)
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Case Report

Article
Stereotactic body radiotherapy as the initial treatment for hepatocellular carcinoma with extensive inferior vena cava and atrium tumor thrombus
Yongjie Shui, Xiaoping Zhu, Jianjun Wu, Tingbo Liang & Qichun Wei
Pages: 5299-5303
Published online: 04 Jul 2019
AbstractforStereotactic body radiotherapy as the initial treatment for hepatocellular carcinoma with extensive inferior vena cava and atrium tumor thrombus | Full Text | References | PDF (1,021.9 KB)
  • 30 Views
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Case Report
Efficacy of afatinib in a HER2 amplification-positive endometrioid adenocarcinoma patient– a case report
Li Zhou, Yifeng Ren, Xia Wang, Dongliu Miao, Analyn Lizaso, Haiyan Li, Han Han-Zhang, Jun Qian & Hui Yang
Pages: 5305-5309
Published online: 04 Jul 2019
AbstractforEfficacy of afatinib in a HER2 amplification-positive endometrioid adenocarcinoma patient– a case report | Full Text | References | PDF (658.8 KB)
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Original Research

Article
RETRACTED ARTICLE: MicroRNA-936 targets FGF2 to inhibit epithelial ovarian cancer aggressiveness by deactivating the PI3K/Akt pathway
Cuihong Li, Shunrui Yu, Shanshan Wu, Ying Ni & Zixuan Pan
Pages: 5311-5322
Published online: 08 Jul 2019
AbstractforRETRACTED ARTICLE: MicroRNA-936 targets FGF2 to inhibit epithelial ovarian cancer aggressiveness by deactivating the PI3K/Akt pathway | PDF (3.9 MB)
  • 11 Views
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Article
TGFβ1 is essential for MSCs-CAFs differentiation and promotes HCT116 cells migration and invasion via JAK/STAT3 signaling
Hao-Xiang Tan, Zhen-Bin Cao, Ting-Ting He, Tao Huang, Cai-Ling Xiang & Yu Liu
Pages: 5323-5334
Published online: 05 Jul 2019
AbstractforTGFβ1 is essential for MSCs-CAFs differentiation and promotes HCT116 cells migration and invasion via JAK/STAT3 signaling | Full Text | References | PDF (6.1 MB)
  • 50 Views
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Article
RETRACTED ARTICLE: GATA1 gene silencing inhibits invasion, proliferation and migration of cholangiocarcinoma stem cells via disrupting the PI3K/AKT pathway
Guang Shi, Hong Zhang, Qiong Yu, Chunmei Hu & Youbo Ji
Pages: 5335-5354
Published online: 05 Jul 2019
AbstractforRETRACTED ARTICLE: GATA1 gene silencing inhibits invasion, proliferation and migration of cholangiocarcinoma stem cells via disrupting the PI3K/AKT pathway | PDF (6.2 MB)
  • 9 Views
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Case Report

Case Report
Successful long-term treatment of non–small cell lung cancer positive for RET rearrangement with pemetrexed
Masayuki Takeda, Kazuko Sakai, Kazuto Nishio & Kazuhiko Nakagawa
Pages: 5355-5358
Published online: 08 Jul 2019
AbstractforSuccessful long-term treatment of non–small cell lung cancer positive for RET rearrangement with pemetrexed | Full Text | References | PDF (560.2 KB)
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Original Research

Article
The combination of the glycolysis inhibitor 2-DG and sorafenib can be effective against sorafenib-tolerant persister cancer cells
Li Wang, Qian Yang, Shaoyong Peng & Xiaoxia Liu
Pages: 5359-5373
Published online: 08 Jul 2019
AbstractforThe combination of the glycolysis inhibitor 2-DG and sorafenib can be effective against sorafenib-tolerant persister cancer cells | Full Text | References | PDF (4 MB)
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Corrigendum

Correction
The role of IRAK1 in breast cancer patients treated with neoadjuvant chemotherapy [Corrigendum]
Page: 5375
Published online: 05 Jul 2019
CitationforThe role of IRAK1 in breast cancer patients treated with neoadjuvant chemotherapy [Corrigendum] | Full Text | PDF (143.5 KB)
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Original Research

Article
Lycorine exerts antitumor activity against osteosarcoma cells in vitro and in vivo xenograft model through the JAK2/STAT3 pathway
Hongzhi Hu, Shangyu Wang, Deyao Shi, Binglong Zhong, Xin Huang, Chunwei Shi & Zengwu Shao
Pages: 5377-5388
Published online: 08 Jul 2019
AbstractforLycorine exerts antitumor activity against osteosarcoma cells in vitro and in vivo xenograft model through the JAK2/STAT3 pathway | Full Text | References | PDF (4.4 MB)
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Case Report

Case Report
Significant benefit of nivolumab combining radiotherapy in metastatic gallbladder cancer patient with strong PD-L1 expression: a case report
Weiwei Kong, Jia Wei, Juan Liu, Yudong Qiu, Jiong Shi, Jian He, Mu Su, Mingzhe Xiao & Baorui Liu
Pages: 5389-5393
Published online: 08 Jul 2019
AbstractforSignificant benefit of nivolumab combining radiotherapy in metastatic gallbladder cancer patient with strong PD-L1 expression: a case report | Full Text | References | PDF (1.6 MB)
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Original Research

Article
Identification and functional characterization of Lys-trimethylation of lactate dehydrogenase A
Lin Li, Zuohui Zhao, Wenguo Jiang, Jisheng Guo & Shuping Zhang
Pages: 5395-5404
Published online: 08 Jul 2019
AbstractforIdentification and functional characterization of Lys-trimethylation of lactate dehydrogenase A | Full Text | References | PDF (2.5 MB)
  • 27 Views
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Article
RETRACTED ARTICLE: Long noncoding RNA DLEU1 aggravates glioma progression via the miR-421/MEF2D axis
Li Feng, Mingyuan He, Min Rao, Jiandong Diao & Yonggang Zhu
Pages: 5405-5414
Published online: 08 Jul 2019
AbstractforRETRACTED ARTICLE: Long noncoding RNA DLEU1 aggravates glioma progression via the miR-421/MEF2D axis | PDF (5.7 MB)
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Article
Dual PI3K/mTOR Inhibitor, XL765, suppresses glioblastoma growth by inducing ER stress-dependent apoptosis
Hang Zhao, Guangyong Chen & Huaxin Liang
Pages: 5415-5424
Published online: 08 Jul 2019
AbstractforDual PI3K/mTOR Inhibitor, XL765, suppresses glioblastoma growth by inducing ER stress-dependent apoptosis | Full Text | References | PDF (2.5 MB)
  • 30 Views
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Article
GLUT5 increases fructose utilization in ovarian cancer
Cuiping Jin, Xiaojin Gong & Yumin Shang
Pages: 5425-5436
Published online: 08 Jul 2019
AbstractforGLUT5 increases fructose utilization in ovarian cancer | Full Text | References | PDF (6 MB)
  • 108 Views
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Article
RETRACTED ARTICLE: microRNA-605 directly targets SOX9 to alleviate the aggressive phenotypes of glioblastoma multiforme cell lines by deactivating the PI3K/Akt pathway
Jianwu Jia, Jing Wang, Meifeng Yin & Yongdong Liu
Pages: 5437-5448
Published online: 08 Jul 2019
AbstractforRETRACTED ARTICLE: microRNA-605 directly targets SOX9 to alleviate the aggressive phenotypes of glioblastoma multiforme cell lines by deactivating the PI3K/Akt pathway | PDF (3.1 MB)
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Case Report

Case Report
t(15; 17) associated with primary myelofibrosis: a case report of an unusual clinical presentation and diagnostic dilemma
Kalyan Nadiminti, Margarida Silverman, Sharathkumar Bhagavathi & Praveen Vikas
Pages: 5449-5455
Published online: 11 Jul 2019
Abstractfort(15; 17) associated with primary myelofibrosis: a case report of an unusual clinical presentation and diagnostic dilemma | Full Text | References | PDF (967.3 KB)
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Review

Review Article
Progressive study of effects of erianin on anticancer activity
Yuying Zhang, Qianqian Zhang, Fanhua Wei & Na Liu
Pages: 5457-5465
Published online: 09 Jul 2019
AbstractforProgressive study of effects of erianin on anticancer activity | Full Text | References | PDF (1.5 MB)
  • 36 Views
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Review Article
Comparative review of drug–drug interactions with epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of non-small-cell lung cancer
Zi-Yi Xu & Jun-Ling Li
Pages: 5467-5484
Published online: 09 Jul 2019
AbstractforComparative review of drug–drug interactions with epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of non-small-cell lung cancer | Full Text | References | PDF (476.7 KB)
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Original Research

Article
Long noncoding RNA DANCR contributes to docetaxel resistance in prostate cancer through targeting the miR-34a-5p/JAG1 pathway
Yongliang Ma, Bo Fan, Zongtao Ren, Bin Liu & Yanchao Wang
Pages: 5485-5497
Published online: 09 Jul 2019
AbstractforLong noncoding RNA DANCR contributes to docetaxel resistance in prostate cancer through targeting the miR-34a-5p/JAG1 pathway | Full Text | References | PDF (3 MB)
  • 33 Views
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Article
G protein-coupled receptor kinase 2 regulating β2-adrenergic receptor signaling in M2-polarized macrophages contributes to hepatocellular carcinoma progression
Jing-Jing Wu, Yang Yang, Wen-Ting Peng, Jia-Chang Sun, Wu-Yi Sun & Wei Wei
Pages: 5499-5513
Published online: 11 Jul 2019
AbstractforG protein-coupled receptor kinase 2 regulating β2-adrenergic receptor signaling in M2-polarized macrophages contributes to hepatocellular carcinoma progression | Full Text | References | PDF (3 MB)
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Article
The total flavonoid of Eucommia ulmoides sensitizes human glioblastoma cells to radiotherapy via HIF-α/MMP-2 pathway and activates intrinsic apoptosis pathway
Yongsheng Wang, Xiangru Tan, Song Li & Shuilu Yang
Pages: 5515-5524
Published online: 11 Jul 2019
AbstractforThe total flavonoid of Eucommia ulmoides sensitizes human glioblastoma cells to radiotherapy via HIF-α/MMP-2 pathway and activates intrinsic apoptosis pathway | Full Text | References | PDF (3.1 MB)
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Article
Synergistic effect of meta-tetra(hydroxyphenyl)chlorin-based photodynamic therapy followed by cisplatin on malignant Hep-2 cells
Kai Xue, Yi-Nan Wang, Xue Zhao, Hong-Xin Zhang, Dan Yu & Chun-Shun Jin
Pages: 5525-5536
Published online: 10 Jul 2019
AbstractforSynergistic effect of meta-tetra(hydroxyphenyl)chlorin-based photodynamic therapy followed by cisplatin on malignant Hep-2 cells | Full Text | References | PDF (3.1 MB)
  • 26 Views
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Article
Tumor suppressive functions of LZTFL1 in hepatocellular carcinoma
Shasha Li, Jingjing Li & Zujiang Yu
Pages: 5537-5544
Published online: 10 Jul 2019
AbstractforTumor suppressive functions of LZTFL1 in hepatocellular carcinoma | Full Text | References | PDF (1.6 MB)
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Case Report

Article
Successful treatment with osimertinib and its subsequent resistance mechanism in a patient with non-small-cell lung cancer harboring acquired EGFR T790M mutation after recovery from AC0010-induced interstitial lung disease
Hanping Wang, Li Zhang, Xiaohua Shi, Xiaotong Zhang & Xiaoyan Si
Pages: 5545-5549
Published online: 10 Jul 2019
AbstractforSuccessful treatment with osimertinib and its subsequent resistance mechanism in a patient with non-small-cell lung cancer harboring acquired EGFR T790M mutation after recovery from AC0010-induced interstitial lung disease | Full Text | References | PDF (1.6 MB)
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Original Research

Article
12-Lipoxygenase promotes epithelial–mesenchymal transition via the Wnt/β-catenin signaling pathway in gastric cancer cells
Xiao-Huang Yang, Ming-Kai Zhuang, Wen-Hui Xie, Fan Du, Yue-Hong Huang, Zhi-Xin Chen, Feng-Lin Chen & Xiao-Zhong Wang
Pages: 5551-5561
Published online: 11 Jul 2019
Abstractfor12-Lipoxygenase promotes epithelial–mesenchymal transition via the Wnt/β-catenin signaling pathway in gastric cancer cells | Full Text | References | PDF (3.7 MB)
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Article
RETRACTED ARTICLE: MicroRNA-652 suppresses malignant phenotypes in glioblastoma multiforme via FOXK1-mediated AKT/mTOR signaling pathway
Huimei Yang, Zhenzhen Song, Xia Wu, Yilei Wu & Chengxia Liu
Pages: 5563-5575
Published online: 10 Jul 2019
AbstractforRETRACTED ARTICLE: MicroRNA-652 suppresses malignant phenotypes in glioblastoma multiforme via FOXK1-mediated AKT/mTOR signaling pathway | PDF (4.3 MB)
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Article
Research on the establishment of a TPM3 monoclonal stable transfected PANC-1 cell line and the experiment of the EMT occurrence in human pancreatic cancer
Shuo Zhou, Xiang Ma, Zhen-Jie Wang, Wei-Yue Zhang, Hai Jiang, San-Dang Li, Tai-Zhe Zhang, Jie Du & Zheng Lu
Pages: 5577-5587
Published online: 11 Jul 2019
AbstractforResearch on the establishment of a TPM3 monoclonal stable transfected PANC-1 cell line and the experiment of the EMT occurrence in human pancreatic cancer | Full Text | References | PDF (2.9 MB)
  • 35 Views
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Article
Malic enzyme 1 (ME1) is a potential oncogene in gastric cancer cells and is associated with poor survival of gastric cancer patients
Yanyan Shi, Siliang Zhou, Pan Wang, Yanlei Guo, Bingteng Xie & Shigang Ding
Pages: 5589-5599
Published online: 11 Jul 2019
AbstractforMalic enzyme 1 (ME1) is a potential oncogene in gastric cancer cells and is associated with poor survival of gastric cancer patients | Full Text | References | PDF (3.5 MB)
  • 41 Views
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Article
miR-21: a promising biomarker for the early detection of colon cancer
Farnaz Dehghan, Sohrab Boozarpour, Zhila Torabizadeh & Sakineh Alijanpour
Pages: 5601-5607
Published online: 11 Jul 2019
AbstractformiR-21: a promising biomarker for the early detection of colon cancer | Full Text | References | PDF (771.8 KB)
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Case Report

Case Report
Endoscopic submucosal dissection of tracheal deep benign fibrous histiocytoma using hybrid knife
Jiang-wei Ma, Yuan Miao, Xu-yong Lin, Qiu-yue Wang, Wei Wang, Jian Kang & Gang Hou
Pages: 5609-5613
Published online: 11 Jul 2019
AbstractforEndoscopic submucosal dissection of tracheal deep benign fibrous histiocytoma using hybrid knife | Full Text | References | PDF (1.3 MB)
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Original Research

Article
LncRNA LINC00668 promotes the progression of breast cancer by inhibiting apoptosis and accelerating cell cycle
Xia Qiu, Jiangnan Dong, Zheng Zhao, Jun Li & Xiaoyan Cai
Pages: 5615-5625
Published online: 11 Jul 2019
AbstractforLncRNA LINC00668 promotes the progression of breast cancer by inhibiting apoptosis and accelerating cell cycle | Full Text | References | PDF (5.2 MB)
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Article
Decitabine enhances cytotoxic effect of T cells with an anti-CD19 chimeric antigen receptor in treatment of lymphoma
Sujun Li, Lei Xue, Min Wang, Ping Qiang, Hui Xu, Xuhan Zhang, Wenyao Kang, Fengtao You, Hanying Xu, Yu Wang, Xin Liu, Lin Yang & Xingbing Wang
Pages: 5627-5638
Published online: 12 Jul 2019
AbstractforDecitabine enhances cytotoxic effect of T cells with an anti-CD19 chimeric antigen receptor in treatment of lymphoma | Full Text | References | PDF (3.6 MB)
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Article
MicroRNA-106b-5p promotes hepatocellular carcinoma development via modulating FOG2
Ling-Xiang Yu, Bo-Lun Zhang, Mu-Yi Yang, Hu Liu, Chao-Hui Xiao, Shao-Geng Zhang & Rong Liu
Pages: 5639-5647
Published online: 15 Jul 2019
AbstractforMicroRNA-106b-5p promotes hepatocellular carcinoma development via modulating FOG2 | Full Text | References | PDF (2.2 MB)
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Corrigendum

Correction
LncRNA PVT1 promotes proliferation, invasion and epithelial–mesenchymal transition of renal cell carcinoma cells through downregulation of miR-16-5p [Corrigendum]
Page: 5649
Published online: 12 Jul 2019
CitationforLncRNA PVT1 promotes proliferation, invasion and epithelial–mesenchymal transition of renal cell carcinoma cells through downregulation of miR-16-5p [Corrigendum] | Full Text | PDF (886.4 KB)
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Original Research

Article
THAP7 promotes cell proliferation by regulating the G1/S phase transition via epigenetically silencing p21 in lung adenocarcinoma
Cai-Ping Chen, Yi Sang, Lijuan Liu, Zhi-Qi Feng, Zibin Liang & Xiaofeng Pei
Pages: 5651-5660
Published online: 12 Jul 2019
AbstractforTHAP7 promotes cell proliferation by regulating the G1/S phase transition via epigenetically silencing p21 in lung adenocarcinoma | Full Text | References | PDF (2.4 MB)
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Article
LAPTM4B knockdown increases the radiosensitivity of EGFR-overexpressing radioresistant nasopharyngeal cancer cells by inhibiting autophagy
Chu Chu, Xiaoshuang Niu, Xiaomin Ou & Chaosu Hu
Pages: 5661-5677
Published online: 15 Jul 2019
AbstractforLAPTM4B knockdown increases the radiosensitivity of EGFR-overexpressing radioresistant nasopharyngeal cancer cells by inhibiting autophagy | Full Text | References | PDF (7.4 MB)
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Case Report

Case Report
Nanosomal docetaxel lipid suspension based chemotherapy in a pregnant MBC patient – a case report
Rajkumar Ramaswamy, Nisarg Joshi, Mujtaba A Khan & Seerin Siddhara
Pages: 5679-5685
Published online: 15 Jul 2019
AbstractforNanosomal docetaxel lipid suspension based chemotherapy in a pregnant MBC patient – a case report | Full Text | References | PDF (834.9 KB)
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Original Research

Article
miR-937 regulates the proliferation and apoptosis via targeting APAF1 in breast cancer
Huiying Fang, Wei Jiang, Zhouhong Jing, Xiaosong Mu & Zhongxun Xiong
Pages: 5687-5699
Published online: 17 Jul 2019
AbstractformiR-937 regulates the proliferation and apoptosis via targeting APAF1 in breast cancer | Full Text | References | PDF (5 MB)
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Article
Matrix metalloproteinase 2 contributes to aggressive phenotype, epithelial-mesenchymal transition and poor outcome in nasopharyngeal carcinoma
Siyi Li & Weiren Luo
Pages: 5701-5711
Published online: 17 Jul 2019
AbstractforMatrix metalloproteinase 2 contributes to aggressive phenotype, epithelial-mesenchymal transition and poor outcome in nasopharyngeal carcinoma | Full Text | References | PDF (3.8 MB)
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Article
Diallyl disulfide inhibits colon cancer metastasis by suppressing Rac1-mediated epithelial-mesenchymal transition
Longzheng Xia, Jingguan Lin, Jian Su, Linda Oyang, Heran Wang, Shiming Tan, Yanyan Tang, Xiaoyan Chen, Wenbin Liu, Xia Luo, Yutong Tian, Jiaxin Liang, Qi Su, Qianjin Liao & Yujuan Zhou
Pages: 5713-5728
Published online: 16 Jul 2019
AbstractforDiallyl disulfide inhibits colon cancer metastasis by suppressing Rac1-mediated epithelial-mesenchymal transition | Full Text | References | PDF (7.3 MB)
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Article
MiR-34c acts as a tumor suppressor in non-small cell lung cancer by inducing endoplasmic reticulum stress through targeting HMGB1
Li Tu, Xiang Long, Weidong Song, Zhongdong Lv, Huadong Zeng, Tiezhu Wang, Xianglu Liu, Juanni Dong & Ping Xu
Pages: 5729-5739
Published online: 16 Jul 2019
AbstractforMiR-34c acts as a tumor suppressor in non-small cell lung cancer by inducing endoplasmic reticulum stress through targeting HMGB1 | Full Text | References | PDF (4.1 MB)
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Article
Sichong formula inhibits the proliferation and migration of human gastric cancer cells
Meng Wang, Zhaochun Tian, Yong Zhu, Jian Ding, Chen Li, Yongkun Zhou & Yunjie Zhang
Pages: 5741-5750
Published online: 16 Jul 2019
AbstractforSichong formula inhibits the proliferation and migration of human gastric cancer cells | Full Text | References | PDF (3.1 MB)
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Article
Oridonin overcomes the gemcitabine resistant PANC-1/Gem cells by regulating GST pi and LRP/1 ERK/JNK signalling
Bili Wang, Can Shen, Yang Li, Ting Zhang, Hui Huang, Jun Ren, Zhengjun Hu, Jian Xu & Bin Xu
Pages: 5751-5765
Published online: 17 Jul 2019
AbstractforOridonin overcomes the gemcitabine resistant PANC-1/Gem cells by regulating GST pi and LRP/1 ERK/JNK signalling | Full Text | References | PDF (4.6 MB)
  • 55 Views
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Article
The LncRNA XIRP2-AS1 predicts favorable prognosis in colon cancer
Fengru Zhou, Feng Shen, Zhuojun Zheng & Jincheng Ruan
Pages: 5767-5778
Published online: 17 Jul 2019
AbstractforThe LncRNA XIRP2-AS1 predicts favorable prognosis in colon cancer | Full Text | References | PDF (3.1 MB)
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Article
Retrospective analysis of sorafenib efficacy and safety in Chinese patients with high recurrence rate of post-hepatic carcinectomy
Desheng Wang, Weridong Jia, Zhiming Wang, Tianfu Wen, Wei Ding, Feng Xia, Ling Zhang, Feixiang Wu, Tao Peng, Bin Liu, Cuncai Zhou, Qichang Zheng, Xiongying Miao, Junping Peng, Zhiyong Huang & Kefeng Dou
Pages: 5779-5791
Published online: 17 Jul 2019
AbstractforRetrospective analysis of sorafenib efficacy and safety in Chinese patients with high recurrence rate of post-hepatic carcinectomy | Full Text | References | PDF (793.8 KB)
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Article
ASAP3 is a downstream target of HIF-1α and is critical for progression of lung adenocarcinoma
Pingping Zhang, Junwei Sun, Jindan Kai, Yi Peng, Xiyou Liu, Fuxiang Zhou & Jianping Wu
Pages: 5793-5803
Published online: 17 Jul 2019
AbstractforASAP3 is a downstream target of HIF-1α and is critical for progression of lung adenocarcinoma | Full Text | References | PDF (3.2 MB)
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Article
A retrospective six-patient series of apatinib for the treatment of persistent or recurrent carcinoma of the cervix
Chao Chen, Shukui Qin, Zixiong Li, Xianwen Luo, Yu Zhang, Jue Zhang & Xiufeng Liu
Pages: 5805-5811
Published online: 17 Jul 2019
AbstractforA retrospective six-patient series of apatinib for the treatment of persistent or recurrent carcinoma of the cervix | Full Text | References | PDF (753.1 KB)
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Review

Review Article
Update on elotuzumab for the treatment of relapsed/refractory multiple myeloma: patients’ selection and perspective
Sabrina Trudel, Philippe Moreau & Cyrille Touzeau
Pages: 5813-5822
Published online: 18 Jul 2019
AbstractforUpdate on elotuzumab for the treatment of relapsed/refractory multiple myeloma: patients’ selection and perspective | Full Text | References | PDF (275.7 KB)
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Original Research

Article
Verticillin A suppresses HGF-induced migration and invasion via repression of the c-Met/FAK/Src pathway in human gastric and cervical cancer cells
Jingxin Lu, Xia Li, Kai Tu, Yuelin Guan, Kwok-Pui Fung & Feiyan Liu
Pages: 5823-5833
Published online: 26 Jul 2019
AbstractforVerticillin A suppresses HGF-induced migration and invasion via repression of the c-Met/FAK/Src pathway in human gastric and cervical cancer cells | Full Text | References | PDF (5 MB)
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Article
Protein kinase C-iota-mediated glycolysis promotes non-small-cell lung cancer progression
Liu Liu, Bei Lei, Lihua Wang, Cheng Chang, Hao Yang, Jianjun Liu, Gang Huang & Wenhui Xie
Pages: 5835-5848
Published online: 18 Jul 2019
AbstractforProtein kinase C-iota-mediated glycolysis promotes non-small-cell lung cancer progression | Full Text | References | PDF (6 MB)
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Article
Hsa_circ_0003998 may be used as a new biomarker for the diagnosis and prognosis of hepatocellular carcinoma
Guang-Lei Qiao, Li Chen, Wei-Hua Jiang, Cheng Yang, Chun-Mei Yang, Li-Na Song, Ying Chen, Hong-Li Yan & Li-Jun Ma
Pages: 5849-5860
Published online: 19 Jul 2019
AbstractforHsa_circ_0003998 may be used as a new biomarker for the diagnosis and prognosis of hepatocellular carcinoma | Full Text | References | PDF (1.9 MB)
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Article
RETRACTED ARTICLE: The prognostic value of LINC01296 in pan-cancers and the molecular regulatory mechanism in hepatocellular carcinoma: a comprehensive study based on data mining, bioinformatics, and in vitro validation
Chaojie Liang, Yongping Zhang, Yu Zhang, Ruihuan Li, Zhimin Wang, Zhigang Wei & Jiansheng Guo
Pages: 5861-5885
Published online: 19 Jul 2019
AbstractforRETRACTED ARTICLE: The prognostic value of LINC01296 in pan-cancers and the molecular regulatory mechanism in hepatocellular carcinoma: a comprehensive study based on data mining, bioinformatics, and in vitro validation | PDF (17.1 MB)
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Article
AEG-1 promotes the growth of gastric cancer through the upregulation of eIF4E expression
Shengjie Wu, Zuhao Zhang, Dandan Wu, Hongling Chen, Xixi Qian, Xuerong Wang & Wenbin Huang
Pages: 5887-5895
Published online: 22 Jul 2019
AbstractforAEG-1 promotes the growth of gastric cancer through the upregulation of eIF4E expression | Full Text | References | PDF (3.2 MB)
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Article
The prognostic significance of SHP2 and its binding protein Hook1 in non-small cell lung cancer
Lingjuan He, Yinyan Li, Xin Huang, Hongqiang Cheng, Yuehai Ke & Linrun Wang
Pages: 5897-5906
Published online: 22 Jul 2019
AbstractforThe prognostic significance of SHP2 and its binding protein Hook1 in non-small cell lung cancer | Full Text | References | PDF (2.2 MB)
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Article
Estradiol promotes the progression of ER+ breast cancer through methylation-mediated RSK4 inactivation
Qiuyun Li, Hui Gao, Huawei Yang, Wei Wei & Yi Jiang
Pages: 5907-5916
Published online: 22 Jul 2019
AbstractforEstradiol promotes the progression of ER+ breast cancer through methylation-mediated RSK4 inactivation | Full Text | References | PDF (2.9 MB)
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Case Report

Article
A case of primary gastric diffuse large B-cell lymphoma occurring in chronic myeloid leukemia
Zhimei Cai, Shuo Liu, Jie Zi, Jinlong Ma & Zheng Ge
Pages: 5917-5923
Published online: 22 Jul 2019
AbstractforA case of primary gastric diffuse large B-cell lymphoma occurring in chronic myeloid leukemia | Full Text | References | PDF (474.4 KB)
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Review

Review Article
High Tiam1 expression predicts positive lymphatic metastasis and worse survival in patients with malignant solid tumors: a systematic review and meta-analysis
Caixia Yang, Chenlin Ma, Yingchun Li, Peng Mo & Yusheng Yang
Pages: 5925-5936
Published online: 25 Jul 2019
AbstractforHigh Tiam1 expression predicts positive lymphatic metastasis and worse survival in patients with malignant solid tumors: a systematic review and meta-analysis | Full Text | References | PDF (2 MB)
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Original Research

Article
MicroRNA-132 inhibits migration, invasion and epithelial-mesenchymal transition via TGFβ1/Smad2 signaling pathway in human bladder cancer
Xi Chao Wei & Zhong Hua Lv
Pages: 5937-5945
Published online: 23 Jul 2019
AbstractforMicroRNA-132 inhibits migration, invasion and epithelial-mesenchymal transition via TGFβ1/Smad2 signaling pathway in human bladder cancer | Full Text | References | PDF (2.6 MB)
  • 27 Views
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Article
Fasting blood glucose levels and prognosis in patients with non-small-cell lung cancer: a prospective cohort study in China
Jin-Rong Yang, Guo-Chong Chen, Jia-Ying Xu, Chen-Jie Ling, Na Yu, Jing Yang, Da-Xiong Zeng, Min-Jing Gu, Da-Peng Li, Yu-Song Zhang & Li-Qiang Qin
Pages: 5947-5953
Published online: 23 Jul 2019
AbstractforFasting blood glucose levels and prognosis in patients with non-small-cell lung cancer: a prospective cohort study in China | Full Text | References | PDF (237 KB)
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Article
14-Deoxycoleon U-induced endoplasmic reticulum stress-mediated apoptosis, autophagy, and cell cycle arrest in lung adenocarcinoma
Xiaozhi Peng, Yijun Tu, San Fu, Yu Xia, Chaozhi Ma, Yanfang Yang, Hezhen Wu, Yanwen Liu & Pengtao You
Pages: 5955-5965
Published online: 30 Jul 2019
Abstractfor14-Deoxycoleon U-induced endoplasmic reticulum stress-mediated apoptosis, autophagy, and cell cycle arrest in lung adenocarcinoma | Full Text | References | PDF (4.2 MB)
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Article
MicroRNA-27a downregulates the expression of Hsp90 and enhances the radiosensitivity in esophageal squamous cell carcinoma
Xintong Wang, Dianzheng An, Xiaomeng Liu, Xinlei Wang & Baosheng Li
Pages: 5967-5977
Published online: 23 Jul 2019
AbstractforMicroRNA-27a downregulates the expression of Hsp90 and enhances the radiosensitivity in esophageal squamous cell carcinoma | Full Text | References | PDF (3.2 MB)
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Article
Identification of seven-gene signature for prediction of lung squamous cell carcinoma
Zhe Wang, Zhongmiao Wang, Xing Niu, Jie Liu, Zhuning Wang, Lijie Chen & Baoli Qin
Pages: 5979-5988
Published online: 24 Jul 2019
AbstractforIdentification of seven-gene signature for prediction of lung squamous cell carcinoma | Full Text | References | PDF (3.2 MB)
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Article
LINC00958-MYC positive feedback loop modulates resistance of head and neck squamous cell carcinoma cells to chemo- and radiotherapy in vitro
Shanshan Huang, Zhengyu Zhan, Li Li, Hui Guo, Yangyang Yao, Miao Feng, Jun Deng & Jianping Xiong
Pages: 5989-6000
Published online: 24 Jul 2019
AbstractforLINC00958-MYC positive feedback loop modulates resistance of head and neck squamous cell carcinoma cells to chemo- and radiotherapy in vitro | Full Text | References | PDF (2.4 MB)
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Article
The role of PEG3 in the occurrence and prognosis of colon cancer
Ting Zhou, Wei Lin, Qiongni Zhu, Helen Renaud, Xiaowei Liu, Ruidong Li, Cui Tang, Chong Ma, Tai Rao, Zhirong Tan & Ying Guo
Pages: 6001-6012
Published online: 25 Jul 2019
AbstractforThe role of PEG3 in the occurrence and prognosis of colon cancer | Full Text | References | PDF (2.2 MB)
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Review

Article
Role of OCT1 in hepatocellular carcinoma
Jingguo Li, Zhengyi Yang & Biguang Tuo
Pages: 6013-6022
Published online: 25 Jul 2019
AbstractforRole of OCT1 in hepatocellular carcinoma | Full Text | References | PDF (916.7 KB)
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Article
Immune checkpoint inhibitors in esophageal squamous cell carcinoma: progress and opportunities
Ruidi Jiao, Hui Luo, Wenbo Xu & Hong Ge
Pages: 6023-6032
Published online: 29 Jul 2019
AbstractforImmune checkpoint inhibitors in esophageal squamous cell carcinoma: progress and opportunities | Full Text | References | PDF (314.1 KB)
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Article
EGCG overcomes gefitinib resistance by inhibiting autophagy and augmenting cell death through targeting ERK phosphorylation in NSCLC
Jiao Meng, Cuicui Chang, Yuhua Chen, Fangfang Bi, Chen Ji & Wei Liu
Pages: 6033-6043
Published online: 26 Jul 2019
AbstractforEGCG overcomes gefitinib resistance by inhibiting autophagy and augmenting cell death through targeting ERK phosphorylation in NSCLC | Full Text | References | PDF (1.4 MB)
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Article
Frequency and clinical features of BRAF mutations among patients with stage III/IV lung adenocarcinoma without EGFR/ALK aberrations
Ho Cheol Kim, Yeh Rim Kang, Wonjun Ji, Yeon Joo Kim, Shinkyo Yoon, Jae Cheol Lee & Chang-Min Choi
Pages: 6045-6052
Published online: 26 Jul 2019
AbstractforFrequency and clinical features of BRAF mutations among patients with stage III/IV lung adenocarcinoma without EGFR/ALK aberrations | Full Text | References | PDF (1.4 MB)
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Article
EP3 receptor antagonist L798,106 reduces proliferation and migration of SK-BR-3 breast cancer cells
Anna Hester, Barbara Salzmann, Martina Rahmeh, Thomas Kolben, Bastian Czogalla, Nina Ditsch, Sven Mahner, Udo Jeschke & Theresa Maria Kolben
Pages: 6053-6068
Published online: 29 Jul 2019
AbstractforEP3 receptor antagonist L798,106 reduces proliferation and migration of SK-BR-3 breast cancer cells | Full Text | References | PDF (5.1 MB)
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Article
A temperature-sensitive phase-change hydrogel of topotecan achieves a long-term sustained antitumor effect on retinoblastoma cells
Yan Huo, Qun Wang, Ying Liu, Junyi Wang, Qian Li, Zongyuan Li, Yan Dong, Yifei Huang & Liqiang Wang
Pages: 6069-6082
Published online: 30 Jul 2019
AbstractforA temperature-sensitive phase-change hydrogel of topotecan achieves a long-term sustained antitumor effect on retinoblastoma cells | Full Text | References | PDF (2.8 MB)
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Article
VE-822 mediated inhibition of ATR signaling sensitizes chondrosarcoma to cisplatin via reversion of the DNA damage response
Xiao Liang, Qiya Yang, Wanchun Wang, Tang Liu & Jinyue Hu
Pages: 6083-6092
Published online: 30 Jul 2019
AbstractforVE-822 mediated inhibition of ATR signaling sensitizes chondrosarcoma to cisplatin via reversion of the DNA damage response | Full Text | References | PDF (5.1 MB)
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Article
MiR-203 acts as a radiosensitizer of gastric cancer cells by directly targeting ZEB1
Ying Jiang, Shan Jin, Shisheng Tan, Qi Shen & Yingbo Xue
Pages: 6093-6104
Published online: 30 Jul 2019
AbstractforMiR-203 acts as a radiosensitizer of gastric cancer cells by directly targeting ZEB1 | Full Text | References | PDF (2.7 MB)
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Article
lncRNA FOXD2-AS1 confers cisplatin resistance of non-small-cell lung cancer via regulation of miR185-5p–SIX1 axis
Peng Ge, Lei Cao, Yue-Juan Yao, Rui-Jun Jing, Wei Wang & Han-Jie Li
Pages: 6105-6117
Published online: 30 Jul 2019
AbstractforlncRNA FOXD2-AS1 confers cisplatin resistance of non-small-cell lung cancer via regulation of miR185-5p–SIX1 axis | Full Text | References | PDF (2.7 MB)
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Article
Antitumor effect of kurarinone and underlying mechanism in small cell lung carcinoma cells
Ting-Wen Chung, Chi-Chien Lin, Shih-Chao Lin, Hong-Lin Chan & Ching-Chieh Yang
Pages: 6119-6131
Published online: 05 Aug 2019
AbstractforAntitumor effect of kurarinone and underlying mechanism in small cell lung carcinoma cells | Full Text | References | PDF (6.6 MB)
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Article
miR-495-3p inhibits the cell proliferation, invasion and migration of osteosarcoma by targeting C1q/TNF-related protein 3
Gang Zhao, Liwei Zhang, Dejian Qian, Yifeng Sun & Wei Liu
Pages: 6133-6143
Published online: 02 Aug 2019
AbstractformiR-495-3p inhibits the cell proliferation, invasion and migration of osteosarcoma by targeting C1q/TNF-related protein 3 | Full Text | References | PDF (6.1 MB)
  • 71 Views
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Article
Long noncoding RNA LINC00673 promotes the proliferation and metastasis of epithelial ovarian cancer by associating with opioid growth factor receptor
Tingting Zheng, Junjun Qiu, Chunbo Li, Xiaojing Lin, Xiaoyan Tang & Keqin Hua
Pages: 6145-6156
Published online: 05 Aug 2019
AbstractforLong noncoding RNA LINC00673 promotes the proliferation and metastasis of epithelial ovarian cancer by associating with opioid growth factor receptor | Full Text | References | PDF (4.2 MB)
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Case Report

Review Article
A rare case of acute promyelocytic leukemia with IRF2BP2-RARA fusion; and literature review
Yiping Liu, Fang Xu, Hong Hu, Jingjing Wen, Jing Su, Qiaolin Zhou & Wen Qu
Pages: 6157-6163
Published online: 02 Aug 2019
AbstractforA rare case of acute promyelocytic leukemia with IRF2BP2-RARA fusion; and literature review | Full Text | References | PDF (1.6 MB)
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Original Research

Article
Exploration of bladder cancer-associated methylated miRNAs by methylated DNA immunoprecipitation sequencing
Xin Gao, Wenwen Zheng, Lili Ye, Xiaohong Wen, Shunlan Wang, Hui Cao, Xi Liu, Denggao Huang, Fei Wang & Shufang Zhang
Pages: 6165-6174
Published online: 01 Aug 2019
AbstractforExploration of bladder cancer-associated methylated miRNAs by methylated DNA immunoprecipitation sequencing | Full Text | References | PDF (3.1 MB)
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Article
TGF-β1 mediates lncRNA GAPLINC expression to promote the migration and invasion of non-small cell lung cancer
Jianqiang Zhao, Changmei Wang, Shuai Liu, Xinyou Su & Aimei Ouyang
Pages: 6175-6180
Published online: 02 Aug 2019
AbstractforTGF-β1 mediates lncRNA GAPLINC expression to promote the migration and invasion of non-small cell lung cancer | Full Text | References | PDF (1.6 MB)
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Article
RETRACTED ARTICLE: Circular RNA hsa_circ_0023404 promotes proliferation, migration and invasion in non-small cell lung cancer by regulating miR-217/ZEB1 axis
Chengjun Liu, Zuwang Zhang & Dongdong Qi
Pages: 6181-6189
Published online: 05 Aug 2019
AbstractforRETRACTED ARTICLE: Circular RNA hsa_circ_0023404 promotes proliferation, migration and invasion in non-small cell lung cancer by regulating miR-217/ZEB1 axis | PDF (2.2 MB)
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Article
WTAP is a prognostic marker of high-grade serous ovarian cancer and regulates the progression of ovarian cancer cells
Hai-Lan Yu, Xu-Dong Ma, Jin-Fei Tong, Jian-Qiong Li, Xiao-Jing Guan & Jian-Hua Yang
Pages: 6191-6201
Published online: 06 Aug 2019
AbstractforWTAP is a prognostic marker of high-grade serous ovarian cancer and regulates the progression of ovarian cancer cells | Full Text | References | PDF (2.7 MB)
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Article
Macrophage-associated lncRNA ELMO1-AS1: a novel therapeutic target and prognostic biomarker for hepatocellular carcinoma
Tao Luo, Miao Chen, Yuan Zhao, Duo Wang, Junjie Liu, Jie Chen, Honglin Luo & Lequn Li
Pages: 6203-6216
Published online: 06 Aug 2019
AbstractforMacrophage-associated lncRNA ELMO1-AS1: a novel therapeutic target and prognostic biomarker for hepatocellular carcinoma | Full Text | References | PDF (4.5 MB)
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Article
miRNA-15a regulates the proliferation and apoptosis of papillary thyroid carcinoma via regulating AKT pathway
Jin Jin, Jie Zhang, Yigui Xue, Li Luo, Siyao Wang & Haoming Tian
Pages: 6217-6226
Published online: 06 Aug 2019
AbstractformiRNA-15a regulates the proliferation and apoptosis of papillary thyroid carcinoma via regulating AKT pathway | Full Text | References | PDF (1.4 MB)
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Case Report

Review Article
Whole-exome sequencing insights into pulmonary artery sarcoma mimicking pulmonary embolism: a case report and review
Ying Wu, Jing Huang, Qin Wang, Mei Zhang, Yimin Luo, Xihua Wang, Xiaoli Zhu & Hongbing Liu
Pages: 6227-6235
Published online: 07 Aug 2019
AbstractforWhole-exome sequencing insights into pulmonary artery sarcoma mimicking pulmonary embolism: a case report and review | Full Text | References | PDF (3.4 MB)
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Original Research

Article
Contribution of programmed cell death 6 genetic variations, gender, and smoking status to lung cancer
Te-Chun Shen, Wen-Shin Chang, Te-Chun Hsia, Hsin-Ting Li, Wei-Chun Chen, Chia-Wen Tsai & Da-Tian Bau
Pages: 6237-6244
Published online: 09 Aug 2019
AbstractforContribution of programmed cell death 6 genetic variations, gender, and smoking status to lung cancer | Full Text | References | PDF (598.6 KB)
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Article
Association of miRNA-499 rs3746444 A>G variants with adenocarcinoma of esophagogastric junction (AEG) risk and lymph node status
Weifeng Tang, Yafeng Wang, Huiwen Pan, Hao Qiu & Shuchen Chen
Pages: 6245-6252
Published online: 08 Aug 2019
AbstractforAssociation of miRNA-499 rs3746444 A>G variants with adenocarcinoma of esophagogastric junction (AEG) risk and lymph node status | Full Text | References | PDF (257.3 KB)
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Article
Oxymatrine reverses epithelial-mesenchymal transition in breast cancer cells by depressing αⅤβ3 integrin/FAK/PI3K/Akt signaling activation
Yan Chen, Lin Chen, Jing-Yu Zhang, Zong-Yue Chen, Ting-ting Liu, Yan-Yan Zhang, Ling-Yun Fu, Shuang-Qin Fan, Min-Qin Zhang, Shi-quan Gan, Nen-ling Zhang & Xiang-Chun Shen
Pages: 6253-6265
Published online: 08 Aug 2019
AbstractforOxymatrine reverses epithelial-mesenchymal transition in breast cancer cells by depressing αⅤβ3 integrin/FAK/PI3K/Akt signaling activation | Full Text | References | PDF (8.3 MB)
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Review

Article
PIM-1 kinase: a potential biomarker of triple-negative breast cancer
Jieying Chen & Guangyu Tang
Pages: 6267-6273
Published online: 08 Aug 2019
AbstractforPIM-1 kinase: a potential biomarker of triple-negative breast cancer | Full Text | References | PDF (369.4 KB)
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Original Research

Article
Thermo-chemotherapy inhibits the proliferation and metastasis of gastric cancer cells via suppression of EIF5A2 expression
Ming-Chen Ba, Zheng Ba, Shu-Zhong Cui, Yuan-Feng Gong, Cheng Chen, Kun-Peng Lin, Yin-Bing Wu & Yi-Nuo Tu
Pages: 6275-6284
Published online: 09 Aug 2019
AbstractforThermo-chemotherapy inhibits the proliferation and metastasis of gastric cancer cells via suppression of EIF5A2 expression | Full Text | References | PDF (3.9 MB)
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Article
Upregulation of hypoxia-inducible factor 1α mRNA expression was associated with poor prognosis in patients with hepatocellular carcinoma
Wei Cheng, Ziwei Cheng, Zongguo Yang, Dongwei Xing & Minguang Zhang
Pages: 6285-6296
Published online: 09 Aug 2019
AbstractforUpregulation of hypoxia-inducible factor 1α mRNA expression was associated with poor prognosis in patients with hepatocellular carcinoma | Full Text | References | PDF (3.6 MB)
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Article
LncRNA-MALAT1 regulates proliferation and apoptosis of ovarian cancer cells by targeting miR-503-5p
Qian Sun, Qian Li & Fangfang Xie
Pages: 6297-6307
Published online: 09 Aug 2019
AbstractforLncRNA-MALAT1 regulates proliferation and apoptosis of ovarian cancer cells by targeting miR-503-5p | Full Text | References | PDF (2.4 MB)
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Article
Silencing of CARMA3 inhibits bladder cancer cell migration and invasion via deactivating β-catenin signaling pathway
Xiaojun Man, Tao Liu, Yuanjun Jiang, Zhe Zhang, Yuyan Zhu, Zhenhua Li, Chuize Kong & Jiani He
Pages: 6309-6322
Published online: 09 Aug 2019
AbstractforSilencing of CARMA3 inhibits bladder cancer cell migration and invasion via deactivating β-catenin signaling pathway | Full Text | References | PDF (4.8 MB)
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Article
Long noncoding RNA HCP5 suppresses skin cutaneous melanoma development by regulating RARRES3 gene expression via sponging miR-12
Xihua Wei, Xuelian Gu, Min Ma & Chunxiang Lou
Pages: 6323-6335
Published online: 12 Aug 2019
AbstractforLong noncoding RNA HCP5 suppresses skin cutaneous melanoma development by regulating RARRES3 gene expression via sponging miR-12 | Full Text | References | PDF (2.4 MB)
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Article
Albumin exfoliated titanium disulfide nanosheet: a multifunctional nanoplatform for synergistic photothermal/radiation colon cancer therapy
Chen Cao, Junhui Zhang, Chuanhua Yang, Lili Xiang & Wenneng Liu
Pages: 6337-6347
Published online: 09 Aug 2019
AbstractforAlbumin exfoliated titanium disulfide nanosheet: a multifunctional nanoplatform for synergistic photothermal/radiation colon cancer therapy | Full Text | References | PDF (3.5 MB)
  • 35 Views
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Article
CircLMNB1 promotes colorectal cancer by regulating cell proliferation, apoptosis and epithelial-mesenchymal transition
Chunping He, Chao Huang, Rui Zhou & Honggang Yu
Pages: 6349-6359
Published online: 09 Aug 2019
AbstractforCircLMNB1 promotes colorectal cancer by regulating cell proliferation, apoptosis and epithelial-mesenchymal transition | Full Text | References | PDF (3.4 MB)
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Article
The effect of MTHFD2 on the proliferation and migration of colorectal cancer cell lines
Yameng Wei, Pengfei Liu, Qian Li, Juan Du, Yani Chen, Yu Wang, Haiyan Shi, Yanfeng Wang, Huahua Zhang, Wanjuan Xue, Yi Gao, Dan Li, Yun Feng, Jing Yan, Jiming Han & Jing Zhang
Pages: 6361-6370
Published online: 12 Aug 2019
AbstractforThe effect of MTHFD2 on the proliferation and migration of colorectal cancer cell lines | Full Text | References | PDF (4.4 MB)
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Article
tRNA-derived fragment tRF-03357 promotes cell proliferation, migration and invasion in high-grade serous ovarian cancer
Minmin Zhang, Feifei Li, Jing Wang, Wenzhu He, Yun Li, Hongyan Li, Zhaolian Wei & Yunxia Cao
Pages: 6371-6383
Published online: 16 Aug 2019
AbstractfortRNA-derived fragment tRF-03357 promotes cell proliferation, migration and invasion in high-grade serous ovarian cancer | Full Text | References | PDF (3.9 MB)
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Article
Dosimetric comparison of different algorithms in stereotactic body radiation therapy (SBRT) plan for non-small cell lung cancer (NSCLC)
Jun Zhang, Dazhen Jiang, Huanfan Su, Zhitao Dai, Jing Dai, Hui Liu, Conghua Xie & Haijun Yu
Pages: 6385-6391
Published online: 12 Aug 2019
AbstractforDosimetric comparison of different algorithms in stereotactic body radiation therapy (SBRT) plan for non-small cell lung cancer (NSCLC) | Full Text | References | PDF (1.7 MB)
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Article
FAM163A, a positive regulator of ERK signaling pathway, interacts with 14-3-3β and promotes cell proliferation in squamous cell lung carcinoma
Nan Liu, Haijing Zhou, Xiupeng Zhang, Lin Cai, Jingduo Li, Jing Zhao, Yang Liu, Liang Wang, Chuifeng Fan, Ailin Li & Yuan Miao
Pages: 6393-6406
Published online: 13 Aug 2019
AbstractforFAM163A, a positive regulator of ERK signaling pathway, interacts with 14-3-3β and promotes cell proliferation in squamous cell lung carcinoma | Full Text | References | PDF (6.1 MB)
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Article
Microwave ablation compared with radiofrequency ablation for treatment of hepatocellular carcinoma and liver metastases: a systematic review and meta-analysis
Mrudula B Glassberg, Sudip Ghosh, Jeffrey W Clymer, Rana A Qadeer, Nicole C Ferko, Behnam Sadeghirad, George WJ Wright & Joseph F Amaral
Pages: 6407-6438
Published online: 13 Aug 2019
AbstractforMicrowave ablation compared with radiofrequency ablation for treatment of hepatocellular carcinoma and liver metastases: a systematic review and meta-analysis | Full Text | References | PDF (8.4 MB)
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Article
Bio-physic constraint model using spatial registration of delta 18F-fluorodeoxyglucose positron emission tomography/computed tomography images for predicting radiation pneumonitis in esophageal squamous cell carcinoma patients receiving neoadjuvant chemoradiation
Tien-Chi Hou, Kun-Yao Dai, Ming-Che Wu, Kai-Lung Hua, Hung-Chi Tai, Wen-Chien Huang & Yu-Jen Chen
Pages: 6439-6451
Published online: 13 Aug 2019
AbstractforBio-physic constraint model using spatial registration of delta 18F-fluorodeoxyglucose positron emission tomography/computed tomography images for predicting radiation pneumonitis in esophageal squamous cell carcinoma patients receiving neoadjuvant chemoradiation | Full Text | References | PDF (898.6 KB)
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Article
Establishment of reference intervals for serum [−2]proPSA (p2PSA), %p2PSA and prostate health index in healthy men
Zhi-Yu Wu, Cheng Yang, Jie Luo, Shao-Li Deng, Bin Wu & Ming Chen
Pages: 6453-6460
Published online: 13 Aug 2019
AbstractforEstablishment of reference intervals for serum [−2]proPSA (p2PSA), %p2PSA and prostate health index in healthy men | Full Text | References | PDF (1.1 MB)
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Article
RETRACTED ARTICLE: HIF1α/PD-L1 axis mediates hypoxia-induced cell apoptosis and tumor progression in follicular thyroid carcinoma
Lingyan Zhou, Guofen Cha, Liyu Chen, Chen Yang, Dong Xu & Minghua Ge
Pages: 6461-6470
Published online: 13 Aug 2019
AbstractforRETRACTED ARTICLE: HIF1α/PD-L1 axis mediates hypoxia-induced cell apoptosis and tumor progression in follicular thyroid carcinoma | PDF (5.1 MB)
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Article
LINC00491 as a new molecular marker can promote the proliferation, migration and invasion of colon adenocarcinoma cells
Jiahui Wan, Daiqian Deng, Xiuli Wang, Xiaojin Wang, Shijun Jiang & Rongjun Cui
Pages: 6471-6480
Published online: 13 Aug 2019
AbstractforLINC00491 as a new molecular marker can promote the proliferation, migration and invasion of colon adenocarcinoma cells | Full Text | References | PDF (2.7 MB)
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Review

Article
Chinese perspectives on clinical efficacy and safety of alectinib in patients with ALK-positive advanced non-small cell lung cancer
Hui Yu, Si Sun, Xingjiang Hu, Jinjing Xia, Jialei Wang & Haiquan Chen
Pages: 6481-6495
Published online: 14 Aug 2019
AbstractforChinese perspectives on clinical efficacy and safety of alectinib in patients with ALK-positive advanced non-small cell lung cancer | Full Text | References | PDF (700.9 KB)
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Case Report

Article
Primary spinal epidural diffuse large B-cell lymphoma with paraplegia as the first manifestation: a case report
Yefei Shu, Anlong Wang, Li Yi, Xiaofeng Xu & Wei Yang
Pages: 6497-6501
Published online: 14 Aug 2019
AbstractforPrimary spinal epidural diffuse large B-cell lymphoma with paraplegia as the first manifestation: a case report | Full Text | References | PDF (2 MB)
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Original Research

Article
miR520a-3p suppresses cell proliferation and metastasis by inhibiting the p65–NFκB pathway in glioblastoma
Jing-quan Zhang & Bo Hong
Pages: 6503-6513
Published online: 14 Aug 2019
AbstractformiR520a-3p suppresses cell proliferation and metastasis by inhibiting the p65–NFκB pathway in glioblastoma | Full Text | References | PDF (2.3 MB)
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Article
Efficacy of a new oncolytic adenovirus armed with IL-13 against oral carcinoma models
Kai-Liang Zhang, Rui-Ping Li, Bao-Ping Zhang, Shu-Ting Gao, Bo Li, Chun-Juan Huang, Rui Cao, Jing-Yang Cheng, Xiao-Dong Xie, Zhan-Hai Yu & Xin-Yu Feng
Pages: 6515-6523
Published online: 14 Aug 2019
AbstractforEfficacy of a new oncolytic adenovirus armed with IL-13 against oral carcinoma models | Full Text | References | PDF (1 MB)
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Article
Downregulated miR-585-3p promotes cell growth and proliferation in colon cancer by upregulating PSME3
Chunmei Liu, Juan Yang, Han Wu & Jun Li
Pages: 6525-6534
Published online: 14 Aug 2019
AbstractforDownregulated miR-585-3p promotes cell growth and proliferation in colon cancer by upregulating PSME3 | Full Text | References | PDF (3.2 MB)
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Review

Review Article
Second-generation EGFR and ErbB tyrosine kinase inhibitors as first-line treatments for non-small cell lung cancer
Shouzheng Wang & Junling Li
Pages: 6535-6548
Published online: 15 Aug 2019
AbstractforSecond-generation EGFR and ErbB tyrosine kinase inhibitors as first-line treatments for non-small cell lung cancer | Full Text | References | PDF (1.6 MB)
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Original Research

Article
The efficacy and safety of anlotinib treatment for advanced lung cancer
Lan Shao, Wenxian Wang, Zhengbo Song & Yiping Zhang
Pages: 6549-6554
Published online: 15 Aug 2019
AbstractforThe efficacy and safety of anlotinib treatment for advanced lung cancer | Full Text | References | PDF (356.7 KB)
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Article
Protective effect of Chuquiraga spinosa Lessing associated with simvastatin on N-Nitroso-N-methylurea (NMU)-induced prostate cancer in rats
Jorge Luis Arroyo-Acevedo, Juan Pedro Rojas-Armas, Oscar Herrera-Calderón, Roberto Chávez-Asmat, Hugo Jesús Justil-Guerrero, Cristian Aguilar-Carranza, Edwin Enciso-Roca, Johnny Aldo Tinco-Jayo, Ricardo Ángel Yuli-Posadas, Cesar Franco-Quino & Victor Chumpitaz-Cerrate
Pages: 6555-6562
Published online: 15 Aug 2019
AbstractforProtective effect of Chuquiraga spinosa Lessing associated with simvastatin on N-Nitroso-N-methylurea (NMU)-induced prostate cancer in rats | Full Text | References | PDF (2 MB)
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Corrigendum

Correction
Long non-coding RNA NAP1L6 promotes tumor progression and predicts poor prognosis in prostate cancer by targeting Inhibin-β A [Corrigendum]
Pages: 6563-6564
Published online: 15 Aug 2019
CitationforLong non-coding RNA NAP1L6 promotes tumor progression and predicts poor prognosis in prostate cancer by targeting Inhibin-β A [Corrigendum] | Full Text | PDF (706.8 KB)
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Original Research

Article
Paip1 overexpression is involved in the progression of gastric cancer and predicts shorter survival of diagnosed patients
Qianrong Wang, Anna Han, Liyan Chen, Jie Sun, Zhenhua Lin, Xianglan Zhang & Xiangshan Ren
Pages: 6565-6576
Published online: 16 Aug 2019
AbstractforPaip1 overexpression is involved in the progression of gastric cancer and predicts shorter survival of diagnosed patients | Full Text | References | PDF (5.9 MB)
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Article
RETRACTED ARTICLE: Hsa_circ_0008945 promoted breast cancer progression by targeting miR-338-3p
Li Zhang & Fengping Ding
Pages: 6577-6589
Published online: 16 Aug 2019
AbstractforRETRACTED ARTICLE: Hsa_circ_0008945 promoted breast cancer progression by targeting miR-338-3p | PDF (5.8 MB)
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Article
A six-gene-based prognostic model predicts complete remission and overall survival in childhood acute myeloid leukemia
Nan Zhang, Ying Chen, Shifeng Lou, Yan Shen & Jianchuan Deng
Pages: 6591-6604
Published online: 16 Aug 2019
AbstractforA six-gene-based prognostic model predicts complete remission and overall survival in childhood acute myeloid leukemia | Full Text | References | PDF (4.1 MB)
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Article
MicroRNA-26a-5p inhibits proliferation, invasion and metastasis by repressing the expression of Wnt5a in papillary thyroid carcinoma
Dongliang Shi, Haiyan Wang, Mingjian Ding, Meng Yang, Chenhao Li, Wenhua Yang & Liang Chen
Pages: 6605-6616
Published online: 16 Aug 2019
AbstractforMicroRNA-26a-5p inhibits proliferation, invasion and metastasis by repressing the expression of Wnt5a in papillary thyroid carcinoma | Full Text | References | PDF (2.2 MB)
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Article
Systemic inflammation score in locally advanced rectal cancer patients following total mesorectal excision
Yanru Feng, Luying Liu & Yuan Zhu
Pages: 6617-6622
Published online: 19 Aug 2019
AbstractforSystemic inflammation score in locally advanced rectal cancer patients following total mesorectal excision | Full Text | References | PDF (546.7 KB)
  • 22 Views
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Article
LncSNHG3/miR-139-5p/BMI1 axis regulates proliferation, migration, and invasion in hepatocellular carcinoma
Jian Wu, Lingyun Liu, Huilin Jin, Qiao Li, Shutong Wang & Baogang Peng
Pages: 6623-6638
Published online: 19 Aug 2019
AbstractforLncSNHG3/miR-139-5p/BMI1 axis regulates proliferation, migration, and invasion in hepatocellular carcinoma | Full Text | References | PDF (3.5 MB)
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Article
GPX2 suppression of H2O2 stress regulates cervical cancer metastasis and apoptosis via activation of the β-catenin-WNT pathway
Yingxin Wang, Penglong Cao, Mohammed Alshwmi, Nan Jiang, Zhen Xiao, Fengquan Jiang, Juebin Gu, Xiaonan Wang, Xiaoye Sun & Shijun Li
Pages: 6639-6651
Published online: 19 Aug 2019
AbstractforGPX2 suppression of H2O2 stress regulates cervical cancer metastasis and apoptosis via activation of the β-catenin-WNT pathway | Full Text | References | PDF (5.4 MB)
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Article
Long noncoding RNA THAP9-AS1 is induced by Helicobacter pylori and promotes cell growth and migration of gastric cancer
Wenxiao Jia, Jiaqin Zhang, Fang Ma, Shengjie Hao, Xue Li, Ruiting Guo, Qianqian Gao, Yundong Sun, Jihui Jia & Wenjuan Li
Pages: 6653-6663
Published online: 19 Aug 2019
AbstractforLong noncoding RNA THAP9-AS1 is induced by Helicobacter pylori and promotes cell growth and migration of gastric cancer | Full Text | References | PDF (2.2 MB)
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Review

Article
Circulating microRNAs as promising diagnostic biomarkers for pancreatic cancer: a systematic review
Jinru Xue, Erna Jia, Na Ren, Andrew Lindsay & Haixin Yu
Pages: 6665-6684
Published online: 19 Aug 2019
AbstractforCirculating microRNAs as promising diagnostic biomarkers for pancreatic cancer: a systematic review | Full Text | References | PDF (3.1 MB)
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Original Research

Article
Chelidonine enhances the antitumor effect of lenvatinib on hepatocellular carcinoma cells
Fang-jie Hou, Li-xiao Guo, Kai-yan Zheng, Jun-na Song, Qian Wang & Yu-guang Zheng
Pages: 6685-6697
Published online: 19 Aug 2019
AbstractforChelidonine enhances the antitumor effect of lenvatinib on hepatocellular carcinoma cells | Full Text | References | PDF (7.1 MB)
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Article
The tumor suppressive roles of ARHGAP25 in lung cancer cells
Ke Xu, Bin Liu & Yegang Ma
Pages: 6699-6710
Published online: 19 Aug 2019
AbstractforThe tumor suppressive roles of ARHGAP25 in lung cancer cells | Full Text | References | PDF (3.4 MB)
  • 35 Views
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Article
Inhibiting the HPV16 oncogene-mediated glycolysis sensitizes human cervical carcinoma cells to 5-fluorouracil
Dan Ma, Yong Huang & Shurong Song
Pages: 6711-6720
Published online: 19 Aug 2019
AbstractforInhibiting the HPV16 oncogene-mediated glycolysis sensitizes human cervical carcinoma cells to 5-fluorouracil | Full Text | References | PDF (2.7 MB)
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Article
ANO6 promotes cell proliferation and invasion in glioma through regulating the ERK signaling pathway
Zhao-bo Xuan, Ye-ji Wang & Jun Xie
Pages: 6721-6731
Published online: 20 Aug 2019
AbstractforANO6 promotes cell proliferation and invasion in glioma through regulating the ERK signaling pathway | Full Text | References | PDF (3.7 MB)
  • 103 Views
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Article
Linc00467 promotes lung adenocarcinoma proliferation via sponging miR-20b-5p to activate CCND1 expression
Hao Ding, Yuchuan Luo, Ke Hu, Pei Liu & Mengqing Xiong
Pages: 6733-6743
Published online: 21 Aug 2019
AbstractforLinc00467 promotes lung adenocarcinoma proliferation via sponging miR-20b-5p to activate CCND1 expression | Full Text | References | PDF (3.3 MB)
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Article
GJB4 promotes gastric cancer cell proliferation and migration via Wnt/CTNNB1 pathway
GuiYuan Liu, Yi Pang, YaJun Zhang, HaiRong Fu, Wei Xiong & YongHui Zhang
Pages: 6745-6755
Published online: 20 Aug 2019
AbstractforGJB4 promotes gastric cancer cell proliferation and migration via Wnt/CTNNB1 pathway | Full Text | References | PDF (4.2 MB)
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Article
Dual targeting of estrogen receptor α and estrogen-related receptor α: a novel endocrine therapy for endometrial cancer
XiaoDan Mao, Binhua Dong, Min Gao, GuanYu Ruan, MeiMei Huang, Elena Ioana Braicu, Jalid Sehouli & PengMing Sun
Pages: 6757-6767
Published online: 20 Aug 2019
AbstractforDual targeting of estrogen receptor α and estrogen-related receptor α: a novel endocrine therapy for endometrial cancer | Full Text | References | PDF (3.7 MB)
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Article
CITED1 contributes to the progression of papillary thyroid carcinoma via the Wnt/β-catenin signaling pathway
Ying Wang, Huan Huang, Fengqiong Hu, Jia Li, Lie Zhang & Hua Pang
Pages: 6769-6777
Published online: 21 Aug 2019
AbstractforCITED1 contributes to the progression of papillary thyroid carcinoma via the Wnt/β-catenin signaling pathway | Full Text | References | PDF (2.5 MB)
  • 28 Views
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Article
Silencing of estrogen receptor β promotes the invasion and migration of osteosarcoma cells through activating Wnt signaling pathway
Yiping Zhang, Changchang Yin, Xufeng Zhou, Yahua Wu & Lili Wang
Pages: 6779-6788
Published online: 22 Aug 2019
AbstractforSilencing of estrogen receptor β promotes the invasion and migration of osteosarcoma cells through activating Wnt signaling pathway | Full Text | References | PDF (2.3 MB)
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Article
lncRNA DSCAM-AS1 downregulates miR-216b to promote the migration and invasion of colorectal adenocarcinoma cells
Fei Liu, Jianhui Jia, Liping Sun, Qingrui Yu, Hongyan Duan, Dexin Jiao, Zhiqiang Gong, Shendong Zhu, Kexin Jiang, Yijiang He, Liping Chen, Yanni Zhang & Han Sun
Pages: 6789-6795
Published online: 21 Aug 2019
AbstractforlncRNA DSCAM-AS1 downregulates miR-216b to promote the migration and invasion of colorectal adenocarcinoma cells | Full Text | References | PDF (1.3 MB)
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Review

Article
Metabolomics: a promising diagnostic and therapeutic implement for breast cancer
Zhanghan Chen, Zehuan Li, Haoran Li & Ying Jiang
Pages: 6797-6811
Published online: 21 Aug 2019
AbstractforMetabolomics: a promising diagnostic and therapeutic implement for breast cancer | Full Text | References | PDF (364.1 KB)
  • 86 Views
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Original Research

Article
The better effects of microbubble ultrasound transfection of miR-940 on cell proliferation inhibition and apoptosis promotion in human cervical cancer cells
Xiaojun Xiao, Yujuan Zhang, Qi Lin & Keli Zhong
Pages: 6813-6824
Published online: 21 Aug 2019
AbstractforThe better effects of microbubble ultrasound transfection of miR-940 on cell proliferation inhibition and apoptosis promotion in human cervical cancer cells | Full Text | References | PDF (3 MB)
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Article
miR-596 suppresses the expression of Survivin and enhances the sensitivity of osteosarcoma cells to the molecular targeting agent anlotinib
Leisheng Wang, He En, Lei Yang, Yanbing Zhang, Baisheng Sun & Jianjiang Gao
Pages: 6825-6838
Published online: 21 Aug 2019
AbstractformiR-596 suppresses the expression of Survivin and enhances the sensitivity of osteosarcoma cells to the molecular targeting agent anlotinib | Full Text | References | PDF (3 MB)
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Case Report

Article
Resection as first-line therapy for large hepatic sclerosing hemangioma: a case report
Li Xu, Xu Yang, Shan Ke, Xue-mei Ding, Shao-hong Wang, Jun Gao & Wen-bing Sun
Pages: 6839-6842
Published online: 22 Aug 2019
AbstractforResection as first-line therapy for large hepatic sclerosing hemangioma: a case report | Full Text | References | PDF (987.9 KB)
  • 62 Views
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Original Research

Article
MAP3K1 rs889312 genotypes influence survival outcomes of Chinese gastric cancer patients who received adjuvant chemotherapy based on platinum and fluorouracil regimes
Jian Yang, Wei Zheng, Zhi Xu & Jinfei Chen
Pages: 6843-6855
Published online: 22 Aug 2019
AbstractforMAP3K1 rs889312 genotypes influence survival outcomes of Chinese gastric cancer patients who received adjuvant chemotherapy based on platinum and fluorouracil regimes | Full Text | References | PDF (1 MB)
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Article
LncRNA ELF3-AS1 is involved in the regulation of oral squamous cell carcinoma cell proliferation by reprogramming glucose metabolism
Hongxing Chu, Zhengqiang Li, Zekun Gan, Zinan Yang, Zhenzhen Wu & Mingdeng Rong
Pages: 6857-6863
Published online: 22 Aug 2019
AbstractforLncRNA ELF3-AS1 is involved in the regulation of oral squamous cell carcinoma cell proliferation by reprogramming glucose metabolism | Full Text | References | PDF (1.2 MB)
  • 22 Views
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Article
Overexpression of miR-671-5p indicates a poor prognosis in colon cancer and accelerates proliferation, migration, and invasion of colon cancer cells
Wei Jin, Jinsheng Shi & Meiqin Liu
Pages: 6865-6873
Published online: 22 Aug 2019
AbstractforOverexpression of miR-671-5p indicates a poor prognosis in colon cancer and accelerates proliferation, migration, and invasion of colon cancer cells | Full Text | References | PDF (2.9 MB)
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Review

Article
Inhibition of the hedgehog pathway for the treatment of cancer using Itraconazole
Ke Li, Dengyang Fang, Zuming Xiong & Runlan Luo
Pages: 6875-6886
Published online: 23 Aug 2019
AbstractforInhibition of the hedgehog pathway for the treatment of cancer using Itraconazole | Full Text | References | PDF (2.2 MB)
  • 88 Views
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Article
Recent advances and application of PD-1 blockade in sarcoma
Wenli Zuo & Lingdi Zhao
Pages: 6887-6896
Published online: 23 Aug 2019
AbstractforRecent advances and application of PD-1 blockade in sarcoma | Full Text | References | PDF (283.7 KB)
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Original Research

Article
Exosomes derived from HCC cells with different invasion characteristics mediated EMT through TGF-β/Smad signaling pathway
Zhen Qu, Jiawei Feng, Hua Pan, Yong Jiang, Yunfei Duan & Zhenzhong Fa
Pages: 6897-6905
Published online: 23 Aug 2019
AbstractforExosomes derived from HCC cells with different invasion characteristics mediated EMT through TGF-β/Smad signaling pathway | Full Text | References | PDF (3.7 MB)
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Article
Transcription factor E2F1 positively regulates interferon regulatory factor 5 expression in non-small cell lung cancer
Dan-dan Feng, Qian Cao, Dao-qi Zhang, Xiao-lu Wu, Cai-xia Yang, Yu-fei Chen, Tang Yu, Hai-xiao Qi & Guo-ping Zhou
Pages: 6907-6915
Published online: 23 Aug 2019
AbstractforTranscription factor E2F1 positively regulates interferon regulatory factor 5 expression in non-small cell lung cancer | Full Text | References | PDF (1.7 MB)
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Article
RETRACTED ARTICLE: MiR-29a function as tumor suppressor in cervical cancer by targeting SIRT1 and predict patient prognosis
Ping Nan, Yugui Niu, Xiuhua Wang & Qiang Li
Pages: 6917-6925
Published online: 26 Aug 2019
AbstractforRETRACTED ARTICLE: MiR-29a function as tumor suppressor in cervical cancer by targeting SIRT1 and predict patient prognosis | PDF (4 MB)
  • 9 Views
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Article
NLRP3 inflammasome activation by estrogen promotes the progression of human endometrial cancer
Shuang-Ge Liu, Xiao-Xiong Wu, Teng Hua, Xiao-Yan Xin, Di-Lu Feng, Shu-Qi Chi, Xiao-Xiao Wang & Hong-Bo Wang
Pages: 6927-6936
Published online: 27 Aug 2019
AbstractforNLRP3 inflammasome activation by estrogen promotes the progression of human endometrial cancer | Full Text | References | PDF (5.4 MB)
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Article
BRMS1 downregulation is a poor prognostic biomarker in anaplastic thyroid carcinoma patients
Yu Wu, Huijuan Wang, Jingtai Zhi, Linfei Hu, Xiukun Hou, Xianhui Ruan, Xiangqian Zheng, Hui Liu & Ming Gao
Pages: 6937-6945
Published online: 28 Aug 2019
AbstractforBRMS1 downregulation is a poor prognostic biomarker in anaplastic thyroid carcinoma patients | Full Text | References | PDF (2.2 MB)
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Article
RETRACTED ARTICLE: microRNA-493 inhibits tongue squamous cell carcinoma oncogenicity via directly targeting HMGA2
Dan Jiao, Yingying Liu & Zhen Tian
Pages: 6947-6959
Published online: 28 Aug 2019
AbstractforRETRACTED ARTICLE: microRNA-493 inhibits tongue squamous cell carcinoma oncogenicity via directly targeting HMGA2 | PDF (3.9 MB)
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Article
PD-1 inhibitors dependent CD8+ T cells inhibit mouse colon cancer cell metastasis
Chang E Gao, Ming Zhang, Qian Song & Jian Dong
Pages: 6961-6971
Published online: 28 Aug 2019
AbstractforPD-1 inhibitors dependent CD8+ T cells inhibit mouse colon cancer cell metastasis | Full Text | References | PDF (4 MB)
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Article
miR-1271 inhibits growth, invasion and epithelial–mesenchymal transition by targeting ZEB1 in ovarian cancer cells
Yanni Jiao, Guiping Zhu, Jiang Yu, Ying Li, Man Wu, Jing Zhao & Xiangwen Tian
Pages: 6973-6980
Published online: 28 Aug 2019
AbstractformiR-1271 inhibits growth, invasion and epithelial–mesenchymal transition by targeting ZEB1 in ovarian cancer cells | Full Text | References | PDF (2.1 MB)
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Article
Long non-coding RNA LINC00665 gastric cancer tumorigenesis by regulation miR-149-3p/RNF2 axis
Hongyang Qi, Zhanyu Xiao & Yunxi Wang
Pages: 6981-6990
Published online: 28 Aug 2019
AbstractforLong non-coding RNA LINC00665 gastric cancer tumorigenesis by regulation miR-149-3p/RNF2 axis | Full Text | References | PDF (3.4 MB)
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Article
RETRACTED ARTICLE: SNHG8 is upregulated in esophageal squamous cell carcinoma and directly sponges microRNA-411 to increase oncogenicity by upregulating KPNA2
Huali Song, Jinxia Song, Lianwei Lu & Shoubo Li
Pages: 6991-7004
Published online: 28 Aug 2019
AbstractforRETRACTED ARTICLE: SNHG8 is upregulated in esophageal squamous cell carcinoma and directly sponges microRNA-411 to increase oncogenicity by upregulating KPNA2 | PDF (8.9 MB)
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Article
An immune-related gene pairs signature predicts overall survival in serous ovarian carcinoma
Liuyan Zhang, Ping Zhu, Yao Tong, Yuzhuo Wang, Haifen Ma, Xuefei Xia, Yu Zhou, Xingguo Zhang, Feng Gao & Peng Shu
Pages: 7005-7014
Published online: 28 Aug 2019
AbstractforAn immune-related gene pairs signature predicts overall survival in serous ovarian carcinoma | Full Text | References | PDF (2.6 MB)
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Article
MicroRNA-30a-3p inhibits the progression of lung cancer via the PI3K/AKT by targeting DNA methyltransferase 3a
Desheng Wei, Guangmao Yu & Yeping Zhao
Pages: 7015-7024
Published online: 28 Aug 2019
AbstractforMicroRNA-30a-3p inhibits the progression of lung cancer via the PI3K/AKT by targeting DNA methyltransferase 3a | Full Text | References | PDF (5 MB)
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Article
Upregulation of long non-coding RNA FOXP4-AS1 and its regulatory network in hepatocellular carcinoma
Duo Wang, Tao Bai, Guanyu Chen, Junjie Liu, Miao Chen, Yuan Zhao, Tao Luo, Jie Chen, Lequn Li, Chunyan Zhang & Hang Li
Pages: 7025-7038
Published online: 29 Aug 2019
AbstractforUpregulation of long non-coding RNA FOXP4-AS1 and its regulatory network in hepatocellular carcinoma | Full Text | References | PDF (18.3 MB)
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Case Report

Article
Decitabine-containing G-CSF priming regimen overcomes resistance of primary mediastinal neoplasm from early T-cell precursors to conventional chemotherapy: a case report
Yuhuan Yang, Shuna Yao, Jiuyang Zhang, Zheng Yan, Junfeng Chu, Haiying Wang, Zhihua Yao, Fan Zhang, Qingxin Xia & Yanyan Liu
Pages: 7039-7044
Published online: 29 Aug 2019
AbstractforDecitabine-containing G-CSF priming regimen overcomes resistance of primary mediastinal neoplasm from early T-cell precursors to conventional chemotherapy: a case report | Full Text | References | PDF (3.8 MB)
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Original Research

Article
MicroRNA-3651 promotes the growth and invasion of hepatocellular carcinoma cells by targeting PTEN
Xinyang Zhao, Qilong Song, Ge Miao & Xinfeng Zhu
Pages: 7045-7054
Published online: 29 Aug 2019
AbstractforMicroRNA-3651 promotes the growth and invasion of hepatocellular carcinoma cells by targeting PTEN | Full Text | References | PDF (3 MB)
  • 26 Views
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Article
RETRACTED ARTICLE: Circular RNA SMARCA5 inhibits the proliferation, migration, and invasion of non-small cell lung cancer by miR-19b-3p/HOXA9 axis
Yaqiu Wang, Huiping Li, Hong Lu & Yaguang Qin
Pages: 7055-7065
Published online: 30 Aug 2019
AbstractforRETRACTED ARTICLE: Circular RNA SMARCA5 inhibits the proliferation, migration, and invasion of non-small cell lung cancer by miR-19b-3p/HOXA9 axis | PDF (1.5 MB)
  • 7 Views
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Article
Upregulation of SHIP2 participates in the development of breast cancer via promoting Wnt/β-catenin signaling
Juan Zhou, Manman Di & Hui Han
Pages: 7067-7077
Published online: 30 Aug 2019
AbstractforUpregulation of SHIP2 participates in the development of breast cancer via promoting Wnt/β-catenin signaling | Full Text | References | PDF (8.9 MB)
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Article
Intersectin 1 (ITSN1) identified by comprehensive bioinformatic analysis and experimental validation as a key candidate biological target in breast cancer
Chen Xie, Wenmin Xiong, Junyu Li, Xia Wang, Chen Xu & Liping Yang
Pages: 7079-7093
Published online: 30 Aug 2019
AbstractforIntersectin 1 (ITSN1) identified by comprehensive bioinformatic analysis and experimental validation as a key candidate biological target in breast cancer | Full Text | References | PDF (10.5 MB)
  • 30 Views
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Article
RETRACTED ARTICLE: LncRNA XIST depletion prevents cancer progression in invasive pituitary neuroendocrine tumor by inhibiting bFGF via upregulation of microRNA-424-5p
Kai Zhou, Shaoshan Li, Guojia Du, Yandong Fan, Pengfei Wu, Hongjie Sun & Tingrong Zhang
Pages: 7095-7109
Published online: 02 Sep 2019
AbstractforRETRACTED ARTICLE: LncRNA XIST depletion prevents cancer progression in invasive pituitary neuroendocrine tumor by inhibiting bFGF via upregulation of microRNA-424-5p | PDF (3.4 MB)
  • 7 Views
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Article
Atractylodes macrocephala polysaccharides regulate the innate immunity of colorectal cancer cells by modulating the TLR4 signaling pathway
Zifang Feng, Ruibin Yang, Liusong Wu, Shihua Tang, Bin Wei, Lijia Guo, Ling He & Yonghuai Feng
Pages: 7111-7121
Published online: 04 Sep 2019
AbstractforAtractylodes macrocephala polysaccharides regulate the innate immunity of colorectal cancer cells by modulating the TLR4 signaling pathway | Full Text | References | PDF (5.5 MB)
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Case Report

Article
BCOR mutation and TLS-ERG expression in acute myeloid leukemia with monoclonal immunoglobulinemia
Jingxia Jin, Shuna Luo, XingNong Ye & Jian Huang
Pages: 7123-7127
Published online: 02 Sep 2019
AbstractforBCOR mutation and TLS-ERG expression in acute myeloid leukemia with monoclonal immunoglobulinemia | Full Text | References | PDF (2.4 MB)
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Original Research

Article
Prognostic significance of lymphocyte-to-monocyte ratio and platelet-to-lymphocyte ratio in patients with hepatocellular carcinoma undergoing transcatheter arterial chemoembolization and radiofrequency ablation
Yanjun Shen, Huige Wang, Xiangmei Chen, Wendong Li & Jinglong Chen
Pages: 7129-7137
Published online: 02 Sep 2019
AbstractforPrognostic significance of lymphocyte-to-monocyte ratio and platelet-to-lymphocyte ratio in patients with hepatocellular carcinoma undergoing transcatheter arterial chemoembolization and radiofrequency ablation | Full Text | References | PDF (435.9 KB)
  • 32 Views
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Article
DPY30 regulates cervical squamous cell carcinoma by mediating epithelial–mesenchymal transition (EMT)
Feng-xi He, Li-li Zhang, Peng-fei Jin, Dan-dan Liu & Ai-hua Li
Pages: 7139-7147
Published online: 02 Sep 2019
AbstractforDPY30 regulates cervical squamous cell carcinoma by mediating epithelial–mesenchymal transition (EMT) | Full Text | References | PDF (1.9 MB)
  • 17 Views
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Article
G3BP1 activates the TGF-β/Smad signaling pathway to promote gastric cancer
Rui Xiong, Jian-long Gao & Tao Yin
Pages: 7149-7156
Published online: 02 Sep 2019
AbstractforG3BP1 activates the TGF-β/Smad signaling pathway to promote gastric cancer | Full Text | References | PDF (1.4 MB)
  • 37 Views
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Article
Significance of tertiary Gleason pattern 5 in patients with Gleason score 7 after radical prostatectomy: a retrospective cohort study
Jiakun Li, Yaochuan Guo, Shi Qiu, Mingjing He, Kun Jin, Xiaonan Zheng, Xiang Tu, Xinyang Liao, Lu Yang & Qiang Wei
Pages: 7157-7164
Published online: 02 Sep 2019
AbstractforSignificance of tertiary Gleason pattern 5 in patients with Gleason score 7 after radical prostatectomy: a retrospective cohort study | Full Text | References | PDF (1.9 MB)
  • 33 Views
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Article
HOXC13-AS-miR-122-5p-SATB1-C-Myc feedback loop promotes migration, invasion and EMT process in glioma
Ning Liu, Ziyu Wang, Dachao Liu & Peng Xie
Pages: 7165-7173
Published online: 02 Sep 2019
AbstractforHOXC13-AS-miR-122-5p-SATB1-C-Myc feedback loop promotes migration, invasion and EMT process in glioma | Full Text | References | PDF (2.4 MB)
  • 36 Views
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Article
STAT gene family mRNA expression and prognostic value in hepatocellular carcinoma
Zhitao Dong, Yi Chen, Cheng Yang, Meng Zhang, Aixue Chen, Jiamei Yang & Yangqing Huang
Pages: 7175-7191
Published online: 03 Sep 2019
AbstractforSTAT gene family mRNA expression and prognostic value in hepatocellular carcinoma | Full Text | References | PDF (6.7 MB)
  • 39 Views
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Article
Positive correlation between programmed death ligand-1 and p53 in triple-negative breast cancer
Yan Zeng, Cheng-Long Wang, Jie Xian, Qian Ye, Xue Qin, Yi-Wen Tan & You-De Cao
Pages: 7193-7201
Published online: 03 Sep 2019
AbstractforPositive correlation between programmed death ligand-1 and p53 in triple-negative breast cancer | Full Text | References | PDF (1.6 MB)
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Article
MicroRNA-765 sensitizes osteosarcoma cells to cisplatin via downregulating APE1 expression
Wei Liang, Chongyi Li, Mengxia Li, Dong Wang & Zhaoyang Zhong
Pages: 7203-7214
Published online: 03 Sep 2019
AbstractforMicroRNA-765 sensitizes osteosarcoma cells to cisplatin via downregulating APE1 expression | Full Text | References | PDF (2.9 MB)
  • 22 Views
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Article
Downregulation of miR-21 inhibits the malignant phenotype of pancreatic cancer cells by targeting VHL
Jinjin Sun, Zhijia Jiang, Yanxun Li, Kaiqiang Wang, Xing Chen & Geng Liu
Pages: 7215-7226
Published online: 03 Sep 2019
AbstractforDownregulation of miR-21 inhibits the malignant phenotype of pancreatic cancer cells by targeting VHL | Full Text | References | PDF (5 MB)
  • 41 Views
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Review

Article
Therapies targeting the signal pathways of pheochromocytoma and paraganglioma
Yalin Liu, Longfei Liu & Feizhou Zhu
Pages: 7227-7241
Published online: 04 Sep 2019
AbstractforTherapies targeting the signal pathways of pheochromocytoma and paraganglioma | Full Text | References | PDF (2.1 MB)
  • 50 Views
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Original Research

Article
Irisin functions to inhibit malignant growth of human pancreatic cancer cells via downregulation of the PI3K/AKT signaling pathway
Deguo Zhang, Ping Zhang, Luan Li, Nan Tang, Fei Huang, Xianguo Kong, Xueying Tan & Guangjun Shi
Pages: 7243-7249
Published online: 04 Sep 2019
AbstractforIrisin functions to inhibit malignant growth of human pancreatic cancer cells via downregulation of the PI3K/AKT signaling pathway | Full Text | References | PDF (1.6 MB)
  • 37 Views
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Article
Effects of HER2 status on the prognosis of male breast cancer: a population-based study
Liang Chen, Yi Ming Weng, Meng Xue Hu, Min Peng & Qi Bin Song
Pages: 7251-7260
Published online: 05 Sep 2019
AbstractforEffects of HER2 status on the prognosis of male breast cancer: a population-based study | Full Text | References | PDF (3.4 MB)
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Article
Long non-coding RNA XIST promotes malignant behavior of epithelial ovarian cancer
Kun Zuo, Youhong Zhao, Yukun Zheng, De Chen, Xiaoli Liu, Song Du & Qing Liu
Pages: 7261-7267
Published online: 05 Sep 2019
AbstractforLong non-coding RNA XIST promotes malignant behavior of epithelial ovarian cancer | Full Text | References | PDF (1.2 MB)
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Article
Overexpression of TRMT12 may independently predict poor overall survival in patients with head and neck squamous cell carcinoma
Kai Wang, Mengmeng Zheng & Yuan Ren
Pages: 7269-7279
Published online: 05 Sep 2019
AbstractforOverexpression of TRMT12 may independently predict poor overall survival in patients with head and neck squamous cell carcinoma | Full Text | References | PDF (3.9 MB)
  • 38 Views
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Review

Article
Major histocompatibility complex class II molecule in non-small cell lung cancer diagnosis, prognosis and treatment
Hao Wang, Sha Zhao, Xiaoshen Zhang, Keyi Jia, Juan Deng, Caicun Zhou & Yayi He
Pages: 7281-7288
Published online: 05 Sep 2019
AbstractforMajor histocompatibility complex class II molecule in non-small cell lung cancer diagnosis, prognosis and treatment | Full Text | References | PDF (1.1 MB)
  • 37 Views
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Original Research

Article
KRAS rs7973450 A>G increases neuroblastoma risk in Chinese children: a four-center case-control study
Ao Lin, Rui-Xi Hua, Jue Tang, Jinhong Zhu, Ruizhong Zhang, Haixia Zhou, Jiao Zhang, Jiwen Cheng, Huimin Xia & Jing He
Pages: 7289-7295
Published online: 05 Sep 2019
AbstractforKRAS rs7973450 A>G increases neuroblastoma risk in Chinese children: a four-center case-control study | Full Text | References | PDF (374.2 KB)
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Article
In vitro mitochondrial-targeted antioxidant peptide induces apoptosis in cancer cells
Wei Zhan, Xin Liao, Lianghe Li, Zhongsheng Chen, Tian Tian, Lei Yu & Zupeng Chen
Pages: 7297-7306
Published online: 06 Sep 2019
AbstractforIn vitro mitochondrial-targeted antioxidant peptide induces apoptosis in cancer cells | Full Text | References | PDF (3.4 MB)
  • 39 Views
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Article
RETRACTED ARTICLE: MicroRNA-675 directly targets MAPK1 to suppress the oncogenicity of papillary thyroid cancer and is sponged by long non-coding RNA RMRP
Junyi Wang, Tiantian Xiao & Ming Zhao
Pages: 7307-7321
Published online: 06 Sep 2019
AbstractforRETRACTED ARTICLE: MicroRNA-675 directly targets MAPK1 to suppress the oncogenicity of papillary thyroid cancer and is sponged by long non-coding RNA RMRP | PDF (4.6 MB)
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Case Report

Review Article
Response and acquired resistance to savolitinib in a patient with pulmonary sarcomatoid carcinoma harboring MET exon 14 skipping mutation: a case report
Sen Han, Jian Fang, Shun Lu, Linfang Wang, Jing Li, Min Cheng, Yongxin Ren & Weiguo Su
Pages: 7323-7328
Published online: 06 Sep 2019
AbstractforResponse and acquired resistance to savolitinib in a patient with pulmonary sarcomatoid carcinoma harboring MET exon 14 skipping mutation: a case report | Full Text | References | PDF (817.2 KB)
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Review

Article
Review and perspective on adjuvant and neoadjuvant immunotherapies in NSCLC
Chengxiang Yi, Yayi He, Haoran Xia, Helin Zhang & Peng Zhang
Pages: 7329-7336
Published online: 06 Sep 2019
AbstractforReview and perspective on adjuvant and neoadjuvant immunotherapies in NSCLC | Full Text | References | PDF (1.7 MB)
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Original Research

Article
Long noncoding RNA ZEB2-AS1 facilitates laryngeal squamous cell carcinoma progression by miR-6840-3p/PLXNB1 axis
Qiushi Xu, Hongyu Liu, Bing Yu, Wenjing Chen, Lili Zhai, XueYing Li & Yanchun Fang
Pages: 7337-7345
Published online: 06 Sep 2019
AbstractforLong noncoding RNA ZEB2-AS1 facilitates laryngeal squamous cell carcinoma progression by miR-6840-3p/PLXNB1 axis | Full Text | References | PDF (5.4 MB)
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Review

Article
OX40 (CD134) and OX40 ligand, important immune checkpoints in cancer
Juan Deng, Sha Zhao, Xiaoshen Zhang, Keyi Jia, Hao Wang, Caicun Zhou & Yayi He
Pages: 7347-7353
Published online: 06 Sep 2019
AbstractforOX40 (CD134) and OX40 ligand, important immune checkpoints in cancer | Full Text | References | PDF (791.2 KB)
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Case Report

Article
Lenvatinib combined nivolumab injection followed by extended right hepatectomy is a feasible treatment for patients with massive hepatocellular carcinoma: a case report
Xin Chen, Yazhou Zhang, Nu Zhang, Yongsheng Ge & Weidong Jia
Pages: 7355-7359
Published online: 09 Sep 2019
AbstractforLenvatinib combined nivolumab injection followed by extended right hepatectomy is a feasible treatment for patients with massive hepatocellular carcinoma: a case report | Full Text | References | PDF (1.6 MB)
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Original Research

Article
Silencing stomatin-like protein 2 attenuates tumor progression and inflammatory response through repressing CD14 in liver cancer
Xiaolin Pu, Changqing Dong, Wenyu Zhu, Wei Li & Hua Jiang
Pages: 7361-7373
Published online: 09 Sep 2019
AbstractforSilencing stomatin-like protein 2 attenuates tumor progression and inflammatory response through repressing CD14 in liver cancer | Full Text | References | PDF (9.1 MB)
  • 26 Views
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Article
The effects and mechanisms of a biosynthetic ginsenoside 3β,12β-Di-O-Glc-PPD on non-small cell lung cancer
Lu-Lu Huang, Mei Tang, Qian-Qian Du, Chun-Xia Liu, Chen Yan, Jin-Ling Yang & Yan Li
Pages: 7375-7385
Published online: 09 Sep 2019
AbstractforThe effects and mechanisms of a biosynthetic ginsenoside 3β,12β-Di-O-Glc-PPD on non-small cell lung cancer | Full Text | References | PDF (15.9 MB)
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Article
Low microRNA-622 expression predicts poor prognosis and is associated with ZEB2 in glioma
Qian Song, Honggang Pang, Lei Qi, Chen Liang, Tuo Wang, Wei Wang & Ruichun Li
Pages: 7387-7397
Published online: 10 Sep 2019
AbstractforLow microRNA-622 expression predicts poor prognosis and is associated with ZEB2 in glioma | Full Text | References | PDF (2.1 MB)
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Case Report

Article
Great efficacy of afatinib on a patient with lung adenocarcinoma harboring uncommon EGFR delE709_T710insD mutations: a case report
Ning An, Haoyi Wang, Hui Zhu, Weiwei Yan, Wang Jing, Li Kong, Yan Zhang & Jinming Yu
Pages: 7399-7404
Published online: 10 Sep 2019
AbstractforGreat efficacy of afatinib on a patient with lung adenocarcinoma harboring uncommon EGFR delE709_T710insD mutations: a case report | Full Text | References | PDF (1.3 MB)
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Article
High-dose vitamin C suppresses the invasion and metastasis of breast cancer cells via inhibiting epithelial-mesenchymal transition
Ling-Hui Zeng, Qing-Mei Wang, Lin-Yi Feng, Yu-Dun Ke, Qian-Zi Xu, An-Yi Wei, Chong Zhang & Rong-Biao Ying
Pages: 7405-7413
Published online: 10 Sep 2019
AbstractforHigh-dose vitamin C suppresses the invasion and metastasis of breast cancer cells via inhibiting epithelial-mesenchymal transition | Full Text | References | PDF (3 MB)
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Article
Construction of a nomogram for the prediction of prognosis in patients with resectable gastric cancer undergoing fewer than sixteen lymph node biopsies
Zhe Li & Hong Cen
Pages: 7415-7428
Published online: 11 Sep 2019
AbstractforConstruction of a nomogram for the prediction of prognosis in patients with resectable gastric cancer undergoing fewer than sixteen lymph node biopsies | Full Text | References | PDF (3.3 MB)
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Article
Up-regulated long non-coding RNA DUXAP8 promotes cell growth through repressing Krüppel-like factor 2 expression in human hepatocellular carcinoma
Hao Jiang, Xuefei Shi, Guochao Ye, Yongcan Xu, Jiewei Xu, Jun Lu & Wei Lu
Pages: 7429-7436
Published online: 11 Sep 2019
AbstractforUp-regulated long non-coding RNA DUXAP8 promotes cell growth through repressing Krüppel-like factor 2 expression in human hepatocellular carcinoma | Full Text | References | PDF (2.8 MB)
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Article
Ultrasound-microbubbles-mediated microRNA-449a inhibits lung cancer cell growth via the regulation of Notch1
Lingwu Meng, Shaofei Yuan, Linjia Zhu, Zongxiao ShangGuan & Renguo Zhao
Pages: 7437-7450
Published online: 13 Sep 2019
AbstractforUltrasound-microbubbles-mediated microRNA-449a inhibits lung cancer cell growth via the regulation of Notch1 | Full Text | References | PDF (5.1 MB)
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Article
Serum circSETDB1 is a promising biomarker for predicting response to platinum-taxane-combined chemotherapy and relapse in high-grade serous ovarian cancer
Wei Wang, Jinshu Wang, Xinzhong Zhang & Gang Liu
Pages: 7451-7457
Published online: 11 Sep 2019
AbstractforSerum circSETDB1 is a promising biomarker for predicting response to platinum-taxane-combined chemotherapy and relapse in high-grade serous ovarian cancer | Full Text | References | PDF (826.6 KB)
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Article
Contribution of interaction between genetic variants of interleukin-11 and Helicobacter pylori infection to the susceptibility of gastric cancer
Chuanwen Liao, Shuqin Hu, Zihan Zheng & Huazhang Tong
Pages: 7459-7466
Published online: 11 Sep 2019
AbstractforContribution of interaction between genetic variants of interleukin-11 and Helicobacter pylori infection to the susceptibility of gastric cancer | Full Text | References | PDF (2 MB)
  • 41 Views
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Article
The inhibitory effect of oridonin on colon cancer was mediated by deactivation of TGF-β1/Smads-PAI-1 signaling pathway in vitro and vivo
He-Qi Bu, Feng Shen & Junhui Cui
Pages: 7467-7476
Published online: 11 Sep 2019
AbstractforThe inhibitory effect of oridonin on colon cancer was mediated by deactivation of TGF-β1/Smads-PAI-1 signaling pathway in vitro and vivo | Full Text | References | PDF (4.4 MB)
  • 35 Views
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Article
Suppressing Hedgehog signaling reverses drug resistance of refractory acute myeloid leukemia
Kaikai Huang, Zhiqiang Sun, Bingjie Ding, Xuejie Jiang, Zhixiang Wang, Yufeng Zhu & Fanyi Meng
Pages: 7477-7488
Published online: 11 Sep 2019
AbstractforSuppressing Hedgehog signaling reverses drug resistance of refractory acute myeloid leukemia | Full Text | References | PDF (9 MB)
  • 51 Views
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Article
OGDH promotes the progression of gastric cancer by regulating mitochondrial bioenergetics and Wnt/β-catenin signal pathway
Xin Lu, Nan Wu, Wanli Yang, Jia Sun, Kemin Yan & Jing Wu
Pages: 7489-7500
Published online: 12 Sep 2019
AbstractforOGDH promotes the progression of gastric cancer by regulating mitochondrial bioenergetics and Wnt/β-catenin signal pathway | Full Text | References | PDF (7.6 MB)
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Article
Long noncoding RNA ZFAS1 promotes progression of papillary thyroid carcinoma by sponging miR-590-3p and upregulating HMGA2 expression
Houchao Tong, Xi Zhuang, Jingsheng Cai, Yu Ding, Yan Si, Hao Zhang & Meiping Shen
Pages: 7501-7512
Published online: 13 Sep 2019
AbstractforLong noncoding RNA ZFAS1 promotes progression of papillary thyroid carcinoma by sponging miR-590-3p and upregulating HMGA2 expression | Full Text | References | PDF (3.7 MB)
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Article
Epigenetics mechanisms mediate the miR-125a/BRMS1 axis to regulate invasion and metastasis in gastric cancer
Jianbo Xiong, Yi Tu, Zongfeng Feng, Daojiang Li, Zhouwen Yang, Qiuxia Huang, Zhengrong Li, Yi Cao & Zhigang Jie
Pages: 7513-7525
Published online: 12 Sep 2019
AbstractforEpigenetics mechanisms mediate the miR-125a/BRMS1 axis to regulate invasion and metastasis in gastric cancer | Full Text | References | PDF (4.5 MB)
  • 40 Views
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Article
PLK1 contributes to autophagy by regulating MYC stabilization in osteosarcoma cells
Hao Mo, Juliang He, Zhenchao Yuan, Zhenjie Wu, Bin Liu, Xiang Lin & Jian Guan
Pages: 7527-7536
Published online: 12 Sep 2019
AbstractforPLK1 contributes to autophagy by regulating MYC stabilization in osteosarcoma cells | Full Text | References | PDF (3.6 MB)
  • 47 Views
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Article
RETRACTED ARTICLE: Silencing circZFR inhibits the proliferation, migration and invasion of human renal carcinoma cells by regulating miR-206
Mi Wang, Yisheng Gao & Jie Liu
Pages: 7537-7550
Published online: 13 Sep 2019
AbstractforRETRACTED ARTICLE: Silencing circZFR inhibits the proliferation, migration and invasion of human renal carcinoma cells by regulating miR-206 | PDF (7.2 MB)
  • 9 Views
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Article
Restoration of miR-26b expression partially reverses the cisplatin resistance of NSCLC by targeting tafazzin
Shuzhi Zang, Shasha Zhao, Xinyuan Gao, Yunxia Li, Chunlei Zhong & Jianlian Gao
Pages: 7551-7560
Published online: 13 Sep 2019
AbstractforRestoration of miR-26b expression partially reverses the cisplatin resistance of NSCLC by targeting tafazzin | Full Text | References | PDF (2.9 MB)
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Article
Up-regulated LncRNA-ATB regulates the growth and metastasis of cholangiocarcinoma via miR-200c signals
Hai Lin, Lili Yang, Feng Tian, Shuang Nie, Hailang Zhou, Jun Liu & Weichang Chen
Pages: 7561-7571
Published online: 13 Sep 2019
AbstractforUp-regulated LncRNA-ATB regulates the growth and metastasis of cholangiocarcinoma via miR-200c signals | Full Text | References | PDF (4.8 MB)
  • 38 Views
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Article
The Role Of Hepatic Stellate Cells In Promoting Liver Metastasis Of Colorectal Carcinoma
Wen-Hai Huang, Min-Wei Zhou, Yan-Feng Zhu, Jian-Bin Xiang, Zhen-Yang Li, Zi-Hao Wang, Yi-Ming Zhou, Yi Yang, Zong-You Chen & Xiao-Dong Gu
Pages: 7573-7580
Published online: 16 Sep 2019
AbstractforThe Role Of Hepatic Stellate Cells In Promoting Liver Metastasis Of Colorectal Carcinoma | Full Text | References | PDF (3.4 MB)
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Article
Anti-tumor effect of chitin oligosaccharide plus cisplatin in vitro and in vivo
Xing Liu, Yan Zhang, Zhaozhe Liu & Xiaodong Xie
Pages: 7581-7590
Published online: 16 Sep 2019
AbstractforAnti-tumor effect of chitin oligosaccharide plus cisplatin in vitro and in vivo | Full Text | References | PDF (7.5 MB)
  • 32 Views
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Article
GADD45a Mediated Cell Cycle Inhibition Is Regulated By P53 In Bladder Cancer
Na Han, Fang Yuan, Peng Xian, Nan Liu, Jianmin Liu, Haiyan Zhang, Huayong Zhang, Kai Yao & Gangjun Yuan
Pages: 7591-7599
Published online: 16 Sep 2019
AbstractforGADD45a Mediated Cell Cycle Inhibition Is Regulated By P53 In Bladder Cancer | Full Text | References | PDF (3.9 MB)
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Article
Positive feedback loop of lncRNA HOXC-AS2/miR-876-5p/ZEB1 to regulate EMT in glioma
Nan Dong, Junxiu Guo, Song Han, Long Bao, Yi Diao & Zhixiong Lin
Pages: 7601-7609
Published online: 16 Sep 2019
AbstractforPositive feedback loop of lncRNA HOXC-AS2/miR-876-5p/ZEB1 to regulate EMT in glioma | Full Text | References | PDF (4.9 MB)
  • 38 Views
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Article
A novel CXCL8 analog is effective in inhibiting the growth via cell cycle arrest and attenuating invasion of Lewis lung carcinoma
Su-Ya Hsu, Hui-Yuan Yu, Wei-Chen Lee, Chia-En Hsiao, Chih-Lung Wu, Hsi-Tsung Cheng, Li-Jin Lin, Fang Li, Yu-Ting Chou & Jya-Wei Cheng
Pages: 7611-7621
Published online: 16 Sep 2019
AbstractforA novel CXCL8 analog is effective in inhibiting the growth via cell cycle arrest and attenuating invasion of Lewis lung carcinoma | Full Text | References | PDF (4.9 MB)
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Article
MicroRNA-424 regulates cisplatin resistance of gastric cancer by targeting SMURF1 based on GEO database and primary validation in human gastric cancer tissues
Li Lu, Menglin Wu, Yaoheng Lu, Zhicheng Zhao, Tong Liu, Weihua Fu & Weidong Li
Pages: 7623-7636
Published online: 17 Sep 2019
AbstractforMicroRNA-424 regulates cisplatin resistance of gastric cancer by targeting SMURF1 based on GEO database and primary validation in human gastric cancer tissues | Full Text | References | PDF (9.3 MB)
  • 51 Views
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Article
Inhibition of esophageal cancer growth through the suppression of PI3K/AKT/mTOR signaling pathway
Ni Shi, Hao Yu & Tong Chen
Pages: 7637-7647
Published online: 17 Sep 2019
AbstractforInhibition of esophageal cancer growth through the suppression of PI3K/AKT/mTOR signaling pathway | Full Text | References | PDF (3.4 MB)
  • 56 Views
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Case Report

Article
AFP-producing hepatoid adenocarcinoma (HAC) of peritoneum and omentum: a case report and literature review
Man Zou, Yanhui Li, Yuhong Dai, Li Sun, Tingting Huang, Xianglin Yuan & Hong Qiu
Pages: 7649-7654
Published online: 18 Sep 2019
AbstractforAFP-producing hepatoid adenocarcinoma (HAC) of peritoneum and omentum: a case report and literature review | Full Text | References | PDF (3.9 MB)
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Original Research

Article
lncRNA LINC01494 Promotes Proliferation, Migration And Invasion In Glioma Through miR-122-5p/CCNG1 Axis
Chang Li, Guozhang Hu, Bo Wei, Le Wang & Naijie Liu
Pages: 7655-7662
Published online: 18 Sep 2019
AbstractforlncRNA LINC01494 Promotes Proliferation, Migration And Invasion In Glioma Through miR-122-5p/CCNG1 Axis | Full Text | References | PDF (9.3 MB)
  • 28 Views
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Article
FLI-06 Intercepts Notch Signaling And Suppresses The Proliferation And Self-renewal Of Tongue Cancer Cells
Rui-huan Gan, Li-song Lin, Jing Xie, Li Huang, Lin-can Ding, Bo-hua Su, Xian-e Peng, Da-li Zheng & You-guang Lu
Pages: 7663-7674
Published online: 18 Sep 2019
AbstractforFLI-06 Intercepts Notch Signaling And Suppresses The Proliferation And Self-renewal Of Tongue Cancer Cells | Full Text | References | PDF (7.1 MB)
  • 36 Views
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Article
MiR-223-3p targeting epithelial cell transforming sequence 2 oncogene inhibits the activity, apoptosis, invasion and migration of MDA-MB-468 breast cancer cells
Xiaorui Wang, Zhongsheng Tong & Hong Liu
Pages: 7675-7684
Published online: 18 Sep 2019
AbstractforMiR-223-3p targeting epithelial cell transforming sequence 2 oncogene inhibits the activity, apoptosis, invasion and migration of MDA-MB-468 breast cancer cells | Full Text | References | PDF (4.7 MB)
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Review

Article
The Roles And Signaling Pathways Of Phosphatidylethanolamine-Binding Protein 4 In Tumors
Zi-Kang Luo, Qiong-Feng Chen, Xiaoqin Qu & Xiao-Yan Zhou
Pages: 7685-7690
Published online: 18 Sep 2019
AbstractforThe Roles And Signaling Pathways Of Phosphatidylethanolamine-Binding Protein 4 In Tumors | Full Text | References | PDF (243.8 KB)
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Case Report

Article
Durable Response After Combination Of Concurrent Chemoradiotherapy And Anti-PD-1 Therapy In HER2-Negative Advanced Gastric Adenocarcinoma: A Case Report
Shanshan Yu, Luya Cai, Fan Lin, Xueyuan Wu, Cheng Zhang, Xuan Liu & Wenfeng Li
Pages: 7691-7698
Published online: 19 Sep 2019
AbstractforDurable Response After Combination Of Concurrent Chemoradiotherapy And Anti-PD-1 Therapy In HER2-Negative Advanced Gastric Adenocarcinoma: A Case Report | Full Text | References | PDF (3.4 MB)
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Article
Circulating serum exosomal aHIF is a novel prognostic predictor for epithelial ovarian cancer
Xiaoyan Tang, Songping Liu, Yinglei Liu, Xiaojing Lin, Tingting Zheng, Xin Liu, Junjun Qiu & Keqin Hua
Pages: 7699-7711
Published online: 19 Sep 2019
AbstractforCirculating serum exosomal aHIF is a novel prognostic predictor for epithelial ovarian cancer | Full Text | References | PDF (5.1 MB)
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Article
TNF-like ligand 1A is associated with progression and prognosis of human gastric cancer
Yaxian Gao, Yuanyuan Wang, Xiao Wang, Yongwei Wang, Xiaoqing Zhang & Xun Sun
Pages: 7715-7723
Published online: 19 Sep 2019
AbstractforTNF-like ligand 1A is associated with progression and prognosis of human gastric cancer | Full Text | References | PDF (3.4 MB)
  • 24 Views
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Article
The correlation of BER protein, IRF3 with CD8+ T cell and their prognostic significance in upper tract urothelial carcinoma
Lin-ang Wang, Bo Yang, Wen Rao, Hualiang Xiao, Dong Wang & Jun Jiang
Pages: 7725-7735
Published online: 24 Sep 2019
AbstractforThe correlation of BER protein, IRF3 with CD8+ T cell and their prognostic significance in upper tract urothelial carcinoma | Full Text | References | PDF (3.5 MB)
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Article
miR-139-5p functions as a tumor suppressor in cervical cancer by targeting TCF4 and inhibiting Wnt/β-catenin signaling
Xia Ji, Hairong Guo, Shanyu Yin & Haiyan Du
Pages: 7739-7748
Published online: 20 Sep 2019
AbstractformiR-139-5p functions as a tumor suppressor in cervical cancer by targeting TCF4 and inhibiting Wnt/β-catenin signaling | Full Text | References | PDF (3.2 MB)
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Article
Epidermal growth factor receptor (EGFR) gene alteration and protein overexpression in Malaysian triple-negative breast cancer (TNBC) cohort
Zubaidah Zakaria, Muhamad Farid Zulkifle, Wan Atiqah Najiah Wan Hasan, Azlah Kamilah Azhari, Sayyidi Hamzi Abdul Raub, Jeyanthy Eswaran, Meera Soundararajan & Sharifah Noor Akmal Syed Husain
Pages: 7749-7756
Published online: 20 Sep 2019
AbstractforEpidermal growth factor receptor (EGFR) gene alteration and protein overexpression in Malaysian triple-negative breast cancer (TNBC) cohort | Full Text | References | PDF (951.8 KB)
  • 141 Views
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Article
Association Of GSTM1, GSTT1 And GSTP1 Polymorphisms With Breast Cancer Among Jordanian Women
Laith N AL-Eitan, Doaa M Rababa'h, Mansour A Alghamdi & Rame H Khasawneh
Pages: 7757-7765
Published online: 20 Sep 2019
AbstractforAssociation Of GSTM1, GSTT1 And GSTP1 Polymorphisms With Breast Cancer Among Jordanian Women | Full Text | References | PDF (1.1 MB)
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Case Report

Article
Individualized Treatment Analysis Of Breast Cancer With Chronic Renal Failure
Wei Liu, Jin-fu Peng & Meng-jie Tang
Pages: 7767-7772
Published online: 20 Sep 2019
AbstractforIndividualized Treatment Analysis Of Breast Cancer With Chronic Renal Failure | Full Text | References | PDF (2.4 MB)
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Original Research

Article
Intratumoral IL-12 Gene Therapy Inhibits Tumor Growth In A HCC-Hu-PBL-NOD/SCID Murine Model
Zhi-Feng Zhou, Feng Peng, Jie-Yu Li & Yun-Bin Ye
Pages: 7773-7784
Published online: 20 Sep 2019
AbstractforIntratumoral IL-12 Gene Therapy Inhibits Tumor Growth In A HCC-Hu-PBL-NOD/SCID Murine Model | Full Text | References | PDF (6.3 MB)
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Case Series

Article
Treatment Response To Osimertinib In EGFR-Mutated Leptomeningeal Metastases From Non-Small Cell Lung Cancer: A Case Series
Huiying Li, Tingting Yu, Mingmin Huang, Aibin Guo, Xiaoping Qian & Zhenyu Yin
Pages: 7785-7790
Published online: 20 Sep 2019
AbstractforTreatment Response To Osimertinib In EGFR-Mutated Leptomeningeal Metastases From Non-Small Cell Lung Cancer: A Case Series | Full Text | References | PDF (1.2 MB)
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Article
Predictive Significance Of Preoperative Systemic Immune-Inflammation Index Determination In Postoperative Liver Metastasis Of Colorectal Cancer
Yao Lu, Dao Xin & Feng Wang
Pages: 7791-7799
Published online: 20 Sep 2019
AbstractforPredictive Significance Of Preoperative Systemic Immune-Inflammation Index Determination In Postoperative Liver Metastasis Of Colorectal Cancer | Full Text | References | PDF (1.7 MB)
  • 91 Views
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Article
MiR-19a Promotes Migration And Invasion By Targeting RHOB In Osteosarcoma
Ruidong Liu, Liefeng Shen, Niyan Qu, Xia Zhao, Jialiang Wang & Jun Geng
Pages: 7801-7808
Published online: 23 Sep 2019
AbstractforMiR-19a Promotes Migration And Invasion By Targeting RHOB In Osteosarcoma | Full Text | References | PDF (3.4 MB)
  • 33 Views
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Article
The TGF-β/Smad Pathway Inhibitor SB431542 Enhances The Antitumor Effect Of Radiofrequency Ablation On Bladder Cancer Cells
Hong-qing Zhou, Ming-sheng Liu, Ti-bin Deng, Ping-bo Xie, Wei Wang, Tao Shao, Yao Wu & Peng Zhang
Pages: 7809-7821
Published online: 23 Sep 2019
AbstractforThe TGF-β/Smad Pathway Inhibitor SB431542 Enhances The Antitumor Effect Of Radiofrequency Ablation On Bladder Cancer Cells | Full Text | References | PDF (11.7 MB)
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Article
CTHRC1 May Serve As A Prognostic Biomarker For Hepatocellular Carcinoma
Huifang Zhou, Libo Su, Chao Liu, Baosheng Li, Hui Li, Ying Xie & Dianxing Sun
Pages: 7823-7831
Published online: 23 Sep 2019
AbstractforCTHRC1 May Serve As A Prognostic Biomarker For Hepatocellular Carcinoma | Full Text | References | PDF (3.6 MB)
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Case Report

Article
Follicular Lymphoma Presenting With Monoclonal IgM And MYD88 Mutation: A Case Report And Review Of The Literature
Linglong Xu, Xiaoxiao Ding, Limei Ying, Xiaochang Zhang & Nina Lu
Pages: 7833-7842
Published online: 23 Sep 2019
AbstractforFollicular Lymphoma Presenting With Monoclonal IgM And MYD88 Mutation: A Case Report And Review Of The Literature | Full Text | References | PDF (10 MB)
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Article
MAGEC2 Correlates With Unfavorable Prognosis And Promotes Tumor Development In HCC Via Epithelial-Mesenchymal Transition
Xuefeng Gu, Yuan Mao, Chuanbing Shi, Wei Ye, Ning Hou, Li Xu, Yan Chen & Wei Zhao
Pages: 7843-7855
Published online: 24 Sep 2019
AbstractforMAGEC2 Correlates With Unfavorable Prognosis And Promotes Tumor Development In HCC Via Epithelial-Mesenchymal Transition | Full Text | References | PDF (8.3 MB)
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Review

Article
Targeted Therapy For RET-Rearranged Non-Small Cell Lung Cancer: Clinical Development And Future Directions
Christoph Jakob Ackermann, Gustavo Stock, Rebecca Tay, Mohammed Dawod, Fabio Gomes & Raffaele Califano
Pages: 7857-7864
Published online: 24 Sep 2019
AbstractforTargeted Therapy For RET-Rearranged Non-Small Cell Lung Cancer: Clinical Development And Future Directions | Full Text | References | PDF (350.3 KB)
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Article
LINC00565 promotes proliferation and inhibits apoptosis of gastric cancer by targeting miR-665/AKT3 axis
Jianghong Hu, Guohua Ni, Ling Mao, Xianglong Xue, Jijie Zhang, Weixia Wu, Shaoru Zhang, Hong Zhao, Lifang Ding & Lihui Wang
Pages: 7865-7875
Published online: 24 Sep 2019
AbstractforLINC00565 promotes proliferation and inhibits apoptosis of gastric cancer by targeting miR-665/AKT3 axis | Full Text | References | PDF (3.1 MB)
  • 82 Views
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Article
Synergistic effect of a retinoid X receptor-selective ligand bexarotene and docetaxel in prostate cancer
Danyang Shen, Huan Wang, Qiming Zheng, Sheng Cheng, Liwei Xu, Mingchao Wang, Gong H Li & Li Q Xia
Pages: 7877-7886
Published online: 24 Sep 2019
AbstractforSynergistic effect of a retinoid X receptor-selective ligand bexarotene and docetaxel in prostate cancer | Full Text | References | PDF (2.9 MB)
  • 29 Views
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Article
Enumeration And Characterization Of Circulating Tumor Cells And Its Application In Advanced Gastric Cancer
Boran Cheng, Gangling Tong, Xuan Wu, Wenwu Cai, Zhu Li, Zhongyi Tong, Lirui He, Shaokang Yu & Shubin Wang
Pages: 7887-7896
Published online: 25 Sep 2019
AbstractforEnumeration And Characterization Of Circulating Tumor Cells And Its Application In Advanced Gastric Cancer | Full Text | References | PDF (4.3 MB)
  • 44 Views
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Article
Expression Of BMP7 In Ovarian Cancer And Biological Effect Of BMP7 Knockdown On Ovarian Cancer Cells
Hongwei Guan, Juan Li, Rui Sun, Wei Liu, Mei Feng, Hui Ma & Changzhong Li
Pages: 7897-7909
Published online: 26 Sep 2019
AbstractforExpression Of BMP7 In Ovarian Cancer And Biological Effect Of BMP7 Knockdown On Ovarian Cancer Cells | Full Text | References | PDF (8.4 MB)
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Article
LncRNA RHPN1-AS1 Targeting miR-625/REG3A Promotes Cell Proliferation And Invasion Of Glioma Cells
Peng Cui, Jichun Su, Qingmin Li, Guangming Xu & Ningxi Zhu
Pages: 7911-7921
Published online: 26 Sep 2019
AbstractforLncRNA RHPN1-AS1 Targeting miR-625/REG3A Promotes Cell Proliferation And Invasion Of Glioma Cells | Full Text | References | PDF (6 MB)
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Article
Genetic association of XRCC5 gene polymorphisms with breast cancer among Jordanian women
Laith N AL-Eitan, Doaa M Rababa’h, Mansour A Alghamdi & Rame H Khasawneh
Pages: 7923-7928
Published online: 26 Sep 2019
AbstractforGenetic association of XRCC5 gene polymorphisms with breast cancer among Jordanian women | Full Text | References | PDF (906 KB)
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Review

Article
The Impact Of Succinate Dehydrogenase Gene (SDH) Mutations In Renal Cell Carcinoma (RCC): A Systematic Review
Seyed Mohammad Kazem Aghamir, Ramin Heshmat, Mehdi Ebrahimi, Seyed Ebrahim Ketabchi, Somayeh Parichehreh Dizaji & Fatemeh Khatami
Pages: 7929-7940
Published online: 26 Sep 2019
AbstractforThe Impact Of Succinate Dehydrogenase Gene (SDH) Mutations In Renal Cell Carcinoma (RCC): A Systematic Review | Full Text | References | PDF (473.2 KB)
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Article
The Surgical Morbidity And Oncological Outcome Of Total Laparoscopic Radical Trachelectomy Versus Total Laparoscopic Radical Hysterectomy For Early Stage Cervical Cancer: A Retrospective Study With 11-Year Follow-Up
Qi Lu, Zhiqiang Zhang, Meizhu Xiao, Chongdong Liu & Zhenyu Zhang
Pages: 7941-7947
Published online: 26 Sep 2019
AbstractforThe Surgical Morbidity And Oncological Outcome Of Total Laparoscopic Radical Trachelectomy Versus Total Laparoscopic Radical Hysterectomy For Early Stage Cervical Cancer: A Retrospective Study With 11-Year Follow-Up | Full Text | References | PDF (280.4 KB)
  • 30 Views
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Article
A Feedback Loop Regulation Of LINC01433 And YAP Promotes Malignant Behavior In Gastric Cancer Cells
Cao Zhang, Haiquan Qian, Ke Liu, Wei Zhao & Lei Wang
Pages: 7949-7962
Published online: 01 Oct 2019
AbstractforA Feedback Loop Regulation Of LINC01433 And YAP Promotes Malignant Behavior In Gastric Cancer Cells | Full Text | References | PDF (10.3 MB)
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Article
Reverse of microtubule-directed chemotherapeutic drugs resistance induced by cancer-associated fibroblasts in breast cancer
Xuebo Li, Qiang Li, Xiuli Yu, Haitao Li & Guoqiang Huang
Pages: 7963-7973
Published online: 27 Sep 2019
AbstractforReverse of microtubule-directed chemotherapeutic drugs resistance induced by cancer-associated fibroblasts in breast cancer | Full Text | References | PDF (2.8 MB)
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Review

Article
Application Of Adoptive Immunotherapy In Ovarian Cancer
Siyu Yang, Xiaojiao Yin, Ying Yue & Siqing Wang
Pages: 7975-7991
Published online: 27 Sep 2019
AbstractforApplication Of Adoptive Immunotherapy In Ovarian Cancer | Full Text | References | PDF (1.6 MB)
  • 58 Views
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Article
RETRACTED ARTICLE: MicroRNA-155-3p promotes breast cancer progression through down-regulating CADM1
Guochao Zhang, Lele Zhong, Hao Luo & Shibing Wang
Pages: 7993-8002
Published online: 27 Sep 2019
AbstractforRETRACTED ARTICLE: MicroRNA-155-3p promotes breast cancer progression through down-regulating CADM1 | PDF (1.9 MB)
  • 37 Views
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Review

Article
Evaluating Acalabrutinib In The Treatment Of Mantle Cell Lymphoma: Design, Development, And Place In Therapy
Jennifer Girard, John Reneau, Sumana Devata, Ryan A Wilcox, Mark S Kaminski, Jessica Mercer, Shannon Carty & Tycel J Phillips
Pages: 8003-8014
Published online: 30 Sep 2019
AbstractforEvaluating Acalabrutinib In The Treatment Of Mantle Cell Lymphoma: Design, Development, And Place In Therapy | Full Text | References | PDF (1.8 MB)
  • 53 Views
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Article
Advances Of Chimeric Antigen Receptor T Cell Therapy In Ovarian Cancer
Wenying Yan, Hongmei Hu & Biao Tang
Pages: 8015-8022
Published online: 30 Sep 2019
AbstractforAdvances Of Chimeric Antigen Receptor T Cell Therapy In Ovarian Cancer | Full Text | References | PDF (1,003.8 KB)
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Article
Detection Of Mutations In The Isocitrate Dehydrogenase Genes (IDH1/IDH2) Using castPCRTM In Patients With AML And Their Clinical Impact In Mexico City
Irma Olarte, Anel García, Christian Ramos, Brenda Arratia, Federico Centeno, Johanna Paredes, Etta Rozen, Juan Kassack, Juan Collazo & Adolfo Martínez
Pages: 8023-8031
Published online: 01 Oct 2019
AbstractforDetection Of Mutations In The Isocitrate Dehydrogenase Genes (IDH1/IDH2) Using castPCRTM In Patients With AML And Their Clinical Impact In Mexico City | Full Text | References | PDF (3.4 MB)
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Article
Proton Therapy For Lymphomas: Current State Of The Art
Umberto Ricardi, Maja V Maraldo, Mario Levis & Rahul R Parikh
Pages: 8033-8046
Published online: 01 Oct 2019
AbstractforProton Therapy For Lymphomas: Current State Of The Art | Full Text | References | PDF (3.3 MB)
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Article
LncRNA GATA6-AS inhibits cancer cell migration and invasion in gallbladder cancer by downregulating miR-421
Kezhi Li, Jianwei Tang & Yong Hou
Pages: 8047-8053
Published online: 01 Oct 2019
AbstractforLncRNA GATA6-AS inhibits cancer cell migration and invasion in gallbladder cancer by downregulating miR-421 | Full Text | References | PDF (2.4 MB)
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Article
TCF-4 Regulated lncRNA-XIST Promotes M2 Polarization Of Macrophages And Is Associated With Lung Cancer
Yanbin Sun & Jingjing Xu
Pages: 8055-8062
Published online: 02 Oct 2019
AbstractforTCF-4 Regulated lncRNA-XIST Promotes M2 Polarization Of Macrophages And Is Associated With Lung Cancer | Full Text | References | PDF (5.1 MB)
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Article
Akt/mTOR-Mediated Autophagy Confers Resistance To BET Inhibitor JQ1 In Ovarian Cancer
Wenqing Luan, Yingxin Pang, Rui Li, Xuan Wei, Xiaoxiao Jiao, Juanjuan Shi, Jiangtao Yu, Hongluan Mao & Peishu Liu
Pages: 8063-8074
Published online: 03 Oct 2019
AbstractforAkt/mTOR-Mediated Autophagy Confers Resistance To BET Inhibitor JQ1 In Ovarian Cancer | Full Text | References | PDF (7.7 MB)
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Article
RBPJ inhibits the movability of endometrial carcinoma cells by miR-155/NF-κB/ROS pathway
Yufeng Xiao, Xiaoli Wang, Xiping Dong, Yan Zhang & Haibin Liu
Pages: 8075-8084
Published online: 02 Oct 2019
AbstractforRBPJ inhibits the movability of endometrial carcinoma cells by miR-155/NF-κB/ROS pathway | Full Text | References | PDF (4.4 MB)
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Article
RETRACTED ARTICLE: Circular RNA circ-Foxo3 induced cell apoptosis in urothelial carcinoma via interaction with miR-191-5p
Chunyang Wang, Weiyang Tao, Shaobin Ni & Qiyin Chen
Pages: 8085-8094
Published online: 16 Oct 2019
AbstractforRETRACTED ARTICLE: Circular RNA circ-Foxo3 induced cell apoptosis in urothelial carcinoma via interaction with miR-191-5p | PDF (5.8 MB)
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Article
PTPRU, As A Tumor Suppressor, Inhibits Cancer Stemness By Attenuating Hippo/YAP Signaling Pathway
Jiayi Gu, Zhiqi Zhang, Tingyuan Lang, Xinlin Ma, Linxi Yang, Jia Xu, Cong Tian, Kun Han & Jiangfeng Qiu
Pages: 8095-8104
Published online: 04 Oct 2019
AbstractforPTPRU, As A Tumor Suppressor, Inhibits Cancer Stemness By Attenuating Hippo/YAP Signaling Pathway | Full Text | References | PDF (7 MB)
  • 31 Views
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Article
Hypermethylation Of ADHFE1 Promotes The Proliferation Of Colorectal Cancer Cell Via Modulating Cell Cycle Progression
Yu-Han Hu, Shuai Ma, Xiang-Nan Zhang, Zhe-Ying Zhang, Hui-Fang Zhu, Ying-Hua Ji, Jian Li, Xin-Lai Qian & Yong-Xia Wang
Pages: 8105-8115
Published online: 04 Oct 2019
AbstractforHypermethylation Of ADHFE1 Promotes The Proliferation Of Colorectal Cancer Cell Via Modulating Cell Cycle Progression | Full Text | References | PDF (8.5 MB)
  • 39 Views
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Article
LncRNA LINC01116 Promotes Cancer Cell Proliferation, Migration And Invasion In Gastric Cancer By Positively Interacting With lncRNA CASC11
Xiaohui Su, Jianjun Zhang, Xianfeng Luo, Wei Yang, Yanqing Liu, Yang Liu & Zexing Shan
Pages: 8117-8123
Published online: 03 Oct 2019
AbstractforLncRNA LINC01116 Promotes Cancer Cell Proliferation, Migration And Invasion In Gastric Cancer By Positively Interacting With lncRNA CASC11 | Full Text | References | PDF (4.5 MB)
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Article
RETRACTED ARTICLE: CXCL8 Promotes Glioma Progression By Activating The JAK/STAT1/HIF-1α/Snail Signaling Axis
Zhiming Chen, Lei Mou, Yiheng Pan, Chi Feng, Jingjing Zhang & Junjun Li
Pages: 8125-8138
Published online: 03 Oct 2019
AbstractforRETRACTED ARTICLE: CXCL8 Promotes Glioma Progression By Activating The JAK/STAT1/HIF-1α/Snail Signaling Axis | PDF (14 MB)
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Article
Decreased IFIT2 Expression In Human Non-Small-Cell Lung Cancer Tissues Is Associated With Cancer Progression And Poor Survival Of The Patients
Wenya Su, Wenlu Xiao, Lujun Chen, Qi Zhou, Xiao Zheng, Jingfang Ju, Jingting Jiang & Zhigang Wang
Pages: 8139-8149
Published online: 03 Oct 2019
AbstractforDecreased IFIT2 Expression In Human Non-Small-Cell Lung Cancer Tissues Is Associated With Cancer Progression And Poor Survival Of The Patients | Full Text | References | PDF (4.7 MB)
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Article
Perioperative Targeted Therapy Or Immunotherapy In Non-Small-Cell Lung Cancer
Huanlan Sa, Peng Song, Kewei Ma, Yong Gao, Li Zhang & Deqiang Wang
Pages: 8151-8159
Published online: 03 Oct 2019
AbstractforPerioperative Targeted Therapy Or Immunotherapy In Non-Small-Cell Lung Cancer | Full Text | References | PDF (268.4 KB)
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Article
Communication Of Cancer Cells And Lymphatic Vessels In Cancer: Focus On Bladder Cancer
Zhang-song Wu, Wa Ding, Jiajia Cai, Ghassan Bashir, Yu-qing Li & Song Wu
Pages: 8161-8177
Published online: 03 Oct 2019
AbstractforCommunication Of Cancer Cells And Lymphatic Vessels In Cancer: Focus On Bladder Cancer | Full Text | References | PDF (2.3 MB)
  • 68 Views
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Original Research

Article
Knockdown Of TRIM31 Enhances Colorectal Cancer Radiosensitivity By Inducing DNA Damage And Activating Apoptosis
Hui Zhang, Yun Deng, Liping Liang, Lijun Shen, Ji Zhu, Yaqi Wang, Jing Zhang & Zhen Zhang
Pages: 8179-8188
Published online: 03 Oct 2019
AbstractforKnockdown Of TRIM31 Enhances Colorectal Cancer Radiosensitivity By Inducing DNA Damage And Activating Apoptosis | Full Text | References | PDF (5.5 MB)
  • 86 Views
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Article
Role Of Robot-Assisted Partial Nephrectomy For Renal Cell Carcinomas In The Purpose Of Nephron Sparing
I-Hung Shao, Hung-Cheng Kan, Chung-Yi Liu, Po-Hung Lin, Kai-Jie Yu, See-Tong Pang, Chun-Te Wu, Cheng-Keng Chuang & Ying-Hsu Chang
Pages: 8189-8196
Published online: 04 Oct 2019
AbstractforRole Of Robot-Assisted Partial Nephrectomy For Renal Cell Carcinomas In The Purpose Of Nephron Sparing | Full Text | References | PDF (2 MB)
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Article
circZNF609 promotes the proliferation and migration of gastric cancer by sponging miR-483-3p and regulating CDK6
Weidong Wu, Ningxian Wei, Gang Shao, Chunnan Jiang, Shaoru Zhang & Lihui Wang
Pages: 8197-8205
Published online: 04 Oct 2019
AbstractforcircZNF609 promotes the proliferation and migration of gastric cancer by sponging miR-483-3p and regulating CDK6 | Full Text | References | PDF (2.6 MB)
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Article
Long Noncoding RNA HCP5 Regulates Pancreatic Cancer Gemcitabine (GEM) Resistance By Sponging Hsa-miR-214-3p To Target HDGF
Yunfei Liu, Jiale Wang, Luo Dong, Li Xia, Hongwei Zhu, Zhiqiang Li & Xiao Yu
Pages: 8207-8216
Published online: 04 Oct 2019
AbstractforLong Noncoding RNA HCP5 Regulates Pancreatic Cancer Gemcitabine (GEM) Resistance By Sponging Hsa-miR-214-3p To Target HDGF | Full Text | References | PDF (4.9 MB)
  • 27 Views
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Article
The Roles Of Angiogenesis And Cancer Stem Cells In Sorafenib Drug Resistance In Hepatocellular Carcinoma
Chiung-Chi Cheng, Wei-Ting Chao, Chen-Chun Liao, Jing-Hao Shih, Yih-Shyong Lai, Yung-Hsiang Hsu & Yi-Hsiang Liu
Pages: 8217-8227
Published online: 04 Oct 2019
AbstractforThe Roles Of Angiogenesis And Cancer Stem Cells In Sorafenib Drug Resistance In Hepatocellular Carcinoma | Full Text | References | PDF (8 MB)
  • 42 Views
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Review

Article
Pathophysiologic Mechanisms And Management Of Large Granular Lymphocytic Leukemia Associated Pure Red Cell Aplasia
Zhi-Yuan Qiu, Rong Qin, Guang-Yu Tian, Yan Wang & Ye-Qing Zhang
Pages: 8229-8240
Published online: 04 Oct 2019
AbstractforPathophysiologic Mechanisms And Management Of Large Granular Lymphocytic Leukemia Associated Pure Red Cell Aplasia | Full Text | References | PDF (390.4 KB)
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Original Research

Article
Association Between Genetic Polymorphisms In TYMS And Glioma Risk In Chinese Patients: A Case-Control Study
Li Yao, Linghui Zhou, Yujiao Deng, Yi Zheng, Pengtao Yang, Meng Wang, Shanshan Dong, Qian Hao, Peng Xu, Na Li, Ying Wu, Zhen Zhai, Lijuan Lyu & Zhijun Dai
Pages: 8241-8247
Published online: 07 Oct 2019
AbstractforAssociation Between Genetic Polymorphisms In TYMS And Glioma Risk In Chinese Patients: A Case-Control Study | Full Text | References | PDF (808.4 KB)
  • 46 Views
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Review

Article
Star Circular RNAs In Human Cancer: Progress And Perspectives
Ye Cheng, Hanzhi Sun, Hanjin Wang, Wei Jiang, Weiwei Tang, Chen Lu, Wenling Zhang, Ziyi Chen & Chengyu Lv
Pages: 8249-8261
Published online: 07 Oct 2019
AbstractforStar Circular RNAs In Human Cancer: Progress And Perspectives | Full Text | References | PDF (981.7 KB)
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Article
Reactive Oxygen Species Modulator 1 As An Adverse Prognostic Marker In Stage III Non-Small Cell Lung Cancer Treated With Radiotherapy: A Retrospective Pilot Study
Moonkyoo Kong, Ji-Youn Sung & Seung Hyeun Lee
Pages: 8263-8273
Published online: 09 Oct 2019
AbstractforReactive Oxygen Species Modulator 1 As An Adverse Prognostic Marker In Stage III Non-Small Cell Lung Cancer Treated With Radiotherapy: A Retrospective Pilot Study | Full Text | References | PDF (603 KB)
  • 30 Views
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Article
SOX17 Inhibits Tumor Metastasis Via Wnt Signaling In Endometrial Cancer
Weiqiang Zhou, Kai Wang, Jingyun Wang, Junjie Qu, Guiqiang Du & Yongli Zhang
Pages: 8275-8286
Published online: 07 Oct 2019
AbstractforSOX17 Inhibits Tumor Metastasis Via Wnt Signaling In Endometrial Cancer | Full Text | References | PDF (9.7 MB)
  • 31 Views
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Article
INPP4B As A Prognostic And Diagnostic Marker Regulates Cell Growth Of Pancreatic Cancer Via Activating AKT
Shuyu Zhai, Yuanbin Liu, Xiongxiong Lu, Hao Qian, Xiaomei Tang, Xi Cheng, Yue Wang, Yusheng Shi & Xiaxing Deng
Pages: 8287-8299
Published online: 09 Oct 2019
AbstractforINPP4B As A Prognostic And Diagnostic Marker Regulates Cell Growth Of Pancreatic Cancer Via Activating AKT | Full Text | References | PDF (8.8 MB)
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Article
AKAP12 Endogenous Transcripts Suppress The Proliferation, Migration And Invasion Of Colorectal Cancer Cells By Directly Targeting oncomiR-183-5p
Tingting Hu, Xuan Wu, Ke Li, Yuan Li, Ping He, Zhiyuan Wu, Jie Fan, Weiwei Liu & Ming Guan
Pages: 8301-8310
Published online: 08 Oct 2019
AbstractforAKAP12 Endogenous Transcripts Suppress The Proliferation, Migration And Invasion Of Colorectal Cancer Cells By Directly Targeting oncomiR-183-5p | Full Text | References | PDF (4.9 MB)
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Article
Therapeutic Effect Of First-Line EGFR-TKIs Combined With Concurrent Cranial Radiotherapy On NSCLC Patients With EGFR Activating Mutation And Brain Metastasis: A Retrospective Study
Ning An, Haoyi Wang, Ji Li, Xiaoyang Zhai, Wang Jing, Wenxiao Jia, Li Kong, Hui Zhu & Jinming Yu
Pages: 8311-8318
Published online: 08 Oct 2019
AbstractforTherapeutic Effect Of First-Line EGFR-TKIs Combined With Concurrent Cranial Radiotherapy On NSCLC Patients With EGFR Activating Mutation And Brain Metastasis: A Retrospective Study | Full Text | References | PDF (1.6 MB)
  • 33 Views
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Article
RETRACTED ARTICLE: The Multifunction Of miR-218-5p-Cx43 Axis In Breast Cancer
Chen Xia, Hong Jiang, Fugui Ye & Zhigang Zhuang
Pages: 8319-8328
Published online: 08 Oct 2019
AbstractforRETRACTED ARTICLE: The Multifunction Of miR-218-5p-Cx43 Axis In Breast Cancer | PDF (11.4 MB)
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Article
MiR-200a-3p promoted the malignant behaviors of ovarian cancer cells through regulating PCDH9
Can Shi, Yijun Yang, Lei Zhang, Juanpeng Yu, Shanshan Qin, Hongge Xu & Yingchun Gao
Pages: 8329-8338
Published online: 08 Oct 2019
AbstractforMiR-200a-3p promoted the malignant behaviors of ovarian cancer cells through regulating PCDH9 | Full Text | References | PDF (2 MB)
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Article
miR-92b-3p Functions As A Key Gene In Esophageal Squamous Cell Cancer As Determined By Co-Expression Analysis
Wanpeng Wang, Sengwang Fu, Xiaolu Lin, Jinhui Zheng, Juan Pu, Yun Gu, Weijun Deng, Yanyan Liu, Zhongxiang He, Wei Liang & Chengshi Wang
Pages: 8339-8353
Published online: 14 Oct 2019
AbstractformiR-92b-3p Functions As A Key Gene In Esophageal Squamous Cell Cancer As Determined By Co-Expression Analysis | Full Text | References | PDF (11 MB)
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Article
Five Hub Genes Can Be The Potential DNA Methylation Biomarkers For Cholangiocarcinoma Using Bioinformatics Analysis
Diyu Chen, Hao Wu, Bin He, Yuejie Lu, Wenxuan Wu, Hua Liu, Xiaode Feng, Jianzhong Chen & Jian Wu
Pages: 8355-8365
Published online: 11 Oct 2019
AbstractforFive Hub Genes Can Be The Potential DNA Methylation Biomarkers For Cholangiocarcinoma Using Bioinformatics Analysis | Full Text | References | PDF (7.5 MB)
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Article
miR-942 promotes proliferation and metastasis of hepatocellular carcinoma cells by inhibiting RRM2B
Qifan Zhang, Bili Zhu, Jianping Qian, Kai Wang & Jie Zhou
Pages: 8367-8378
Published online: 11 Oct 2019
AbstractformiR-942 promotes proliferation and metastasis of hepatocellular carcinoma cells by inhibiting RRM2B | Full Text | References | PDF (2.1 MB)
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Article
Systematic nutrition management for locally advanced nasopharyngeal carcinoma patients undergoing radiotherapy
Jian-Feng Huang, Ren-Juan Sun, Wen-Jun Jiang, Ping Wu, Li Zhang, Mei-Qin Xu, Le-Yuan Zhou, Qing-Feng Pang, Ya-Xian Wu, Bo Yang & Fu-Zheng Zhang
Pages: 8379-8386
Published online: 10 Oct 2019
AbstractforSystematic nutrition management for locally advanced nasopharyngeal carcinoma patients undergoing radiotherapy | Full Text | References | PDF (580.8 KB)
  • 68 Views
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Article
The Nuclear Export Inhibitor Selinexor Inhibits Hypoxia Signaling Pathways And 3D Spheroid Growth Of Cancer Cells
Reinhard Depping, Moritz von Fallois, Yosef Landesman & Friederike Katharina Kosyna
Pages: 8387-8399
Published online: 11 Oct 2019
AbstractforThe Nuclear Export Inhibitor Selinexor Inhibits Hypoxia Signaling Pathways And 3D Spheroid Growth Of Cancer Cells | Full Text | References | PDF (4.7 MB)
  • 35 Views
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Article
Integrated Bioinformatics Data Analysis Reveals Prognostic Significance Of SIDT1 In Triple-Negative Breast Cancer
Ya Wang, Hanning Li, Jingjing Ma, Tian Fang, Xiaoting Li, Jiahao Liu, Henok Kessete Afewerky, Xiong Li & Qinglei Gao
Pages: 8401-8410
Published online: 11 Oct 2019
AbstractforIntegrated Bioinformatics Data Analysis Reveals Prognostic Significance Of SIDT1 In Triple-Negative Breast Cancer | Full Text | References | PDF (4 MB)
  • 56 Views
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Article
Roles Of EAAT1, DHFR, And Fetuin-A In The Pathogenesis, Progression And Prognosis Of Chondrosarcoma
Lile He, Xiangyu Shi, Zhongyue Liu, Xiaolei Ren, Chenghao Zhang, Zhulin Yang & Zhihong Li
Pages: 8411-8420
Published online: 14 Oct 2019
AbstractforRoles Of EAAT1, DHFR, And Fetuin-A In The Pathogenesis, Progression And Prognosis Of Chondrosarcoma | Full Text | References | PDF (5.5 MB)
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Article
Novel Tumor Suppressor lncRNA Growth Arrest-Specific 5 (GAS5) In Human Cancer
Yaya Yu & Swei Sunny Hann
Pages: 8421-8436
Published online: 11 Oct 2019
AbstractforNovel Tumor Suppressor lncRNA Growth Arrest-Specific 5 (GAS5) In Human Cancer | Full Text | References | PDF (898.3 KB)
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Review Article
The Role Of PD-1/PD-L1 Axis In Treg Development And Function: Implications For Cancer Immunotherapy
Jiajing Cai, Dongsheng Wang, Guoyuan Zhang & Xiaolan Guo
Pages: 8437-8445
Published online: 15 Oct 2019
AbstractforThe Role Of PD-1/PD-L1 Axis In Treg Development And Function: Implications For Cancer Immunotherapy | Full Text | References | PDF (387.1 KB)
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Clinical Trial Report

Article
Ultra-Low-Dose Bevacizumab For Cerebral Radiation Necrosis: A Prospective Phase II Clinical Study
Hongqing Zhuang, Hongxia Zhuang, Siyu Shi & Yuxia Wang
Pages: 8447-8453
Published online: 11 Oct 2019
AbstractforUltra-Low-Dose Bevacizumab For Cerebral Radiation Necrosis: A Prospective Phase II Clinical Study | Full Text | References | PDF (2.1 MB)
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Article
RETRACTED ARTICLE: Long Noncoding RNA UCA1 Accelerates Nasopharyngeal Carcinoma Cell Progression By Modulating miR-124-3p/ITGB1 Axis
Chunxiu Liu, Hu Zhang & Hui Liu
Pages: 8455-8466
Published online: 11 Oct 2019
AbstractforRETRACTED ARTICLE: Long Noncoding RNA UCA1 Accelerates Nasopharyngeal Carcinoma Cell Progression By Modulating miR-124-3p/ITGB1 Axis | PDF (8 MB)
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Review

Article
Prevention Of Skeletal Related Events In Multiple Myeloma: Focus On The RANK-L Pathway In The Treatment Of Multiple Myeloma
Ricardo D Parrondo & Taimur Sher
Pages: 8467-8478
Published online: 14 Oct 2019
AbstractforPrevention Of Skeletal Related Events In Multiple Myeloma: Focus On The RANK-L Pathway In The Treatment Of Multiple Myeloma | Full Text | References | PDF (407.9 KB)
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Article
Upregulation Of Protein Tyrosine Phosphatase Receptor Type C Associates To The Combination Of Hashimoto’s Thyroiditis And Papillary Thyroid Carcinoma And Is Predictive Of A Poor Prognosis
Yanmeizhi Wu, Jun Han, Kazakova Elena Vladimirovna, Shumei Zhang, Wenhua Lv, Yan Zhang, Esma Jamaspishvili, Jingxue Sun, Qingxiao Fang, Jingjing Meng & Hong Qiao
Pages: 8479-8489
Published online: 14 Oct 2019
AbstractforUpregulation Of Protein Tyrosine Phosphatase Receptor Type C Associates To The Combination Of Hashimoto’s Thyroiditis And Papillary Thyroid Carcinoma And Is Predictive Of A Poor Prognosis | Full Text | References | PDF (4.3 MB)
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Article
Hypoxia-Induced Cleavage Of Soluble ephrinA1 From Cancer Cells Is Mediated By MMP-2 And Associates With Angiogenesis In Oral Squamous Cell Carcinoma
Ting-Ting Ma, Lin Wang, Jun-Lin Wang, Yan-Jie Liu, Yu-Cong Chen, Hu-Jie He & Yong Song
Pages: 8491-8499
Published online: 14 Oct 2019
AbstractforHypoxia-Induced Cleavage Of Soluble ephrinA1 From Cancer Cells Is Mediated By MMP-2 And Associates With Angiogenesis In Oral Squamous Cell Carcinoma | Full Text | References | PDF (8.8 MB)
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Article
RETRACTED ARTICLE: MicroRNA-761 targets FGFR1 to suppress the malignancy of osteosarcoma by deactivating PI3K/Akt pathway
Zhongzhe Lv, Jinming Ma, Jianchuan Wang & Jianmin Lu
Pages: 8501-8513
Published online: 15 Oct 2019
AbstractforRETRACTED ARTICLE: MicroRNA-761 targets FGFR1 to suppress the malignancy of osteosarcoma by deactivating PI3K/Akt pathway | PDF (5.2 MB)
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Article
miR-204 Negatively Regulates Cell Growth And Metastasis By Targeting ROBO4 In Human Bladder Cancer
Yang Li, Rong Chen, Zun Li, Hepeng Cheng, Xiaodong Li, Tieqiang Li & Chaoyang Zhu
Pages: 8515-8524
Published online: 16 Oct 2019
AbstractformiR-204 Negatively Regulates Cell Growth And Metastasis By Targeting ROBO4 In Human Bladder Cancer | Full Text | References | PDF (5.9 MB)
  • 34 Views
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Article
MiR-4766-5p Inhibits The Development And Progression Of Gastric Cancer By Targeting NKAP
Yaning Wei, Yanan Wang, Aimin Zang, Zhiyu Wang, Guotao Fang & Dan Hong
Pages: 8525-8536
Published online: 16 Oct 2019
AbstractforMiR-4766-5p Inhibits The Development And Progression Of Gastric Cancer By Targeting NKAP | Full Text | References | PDF (9 MB)
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Article
NCAPG Promotes The Proliferation Of Hepatocellular Carcinoma Through PI3K/AKT Signaling
Chengwu Gong, Jiyuan Ai, Yun Fan, Jun Gao, Weiwei Liu, Qian Feng, Wenjun Liao & Linquan Wu
Pages: 8537-8552
Published online: 16 Oct 2019
AbstractforNCAPG Promotes The Proliferation Of Hepatocellular Carcinoma Through PI3K/AKT Signaling | Full Text | References | PDF (15.7 MB)
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Article
Long Non-Coding RNA LINC00152 Regulates Cell Proliferation, Migration And Invasion In Esophageal Squamous Cell Carcinoma Via miR-107/Rab10 Axis
Zhigang Zhou & Fei Huang
Pages: 8553-8567
Published online: 17 Oct 2019
AbstractforLong Non-Coding RNA LINC00152 Regulates Cell Proliferation, Migration And Invasion In Esophageal Squamous Cell Carcinoma Via miR-107/Rab10 Axis | Full Text | References | PDF (14.4 MB)
  • 36 Views
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Article
Knockdown of ROS proto-oncogene 1 inhibits migration and invasion in gastric cancer cells by targeting the PI3K/Akt signaling pathway
Jingjing Qiao, Man Li, Dan Sun, Wenhui Li & Yan Xin
Pages: 8569-8582
Published online: 16 Oct 2019
AbstractforKnockdown of ROS proto-oncogene 1 inhibits migration and invasion in gastric cancer cells by targeting the PI3K/Akt signaling pathway | Full Text | References | PDF (7.6 MB)
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Case Report

Article
A Case Report Of Uterine Leiomyosarcoma
Siyu Cao, Yang Liu, Xuechai Bai & Liang Wang
Pages: 8583-8586
Published online: 16 Oct 2019
AbstractforA Case Report Of Uterine Leiomyosarcoma | Full Text | References | PDF (496.4 KB)
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Article
Investigation Of Small Molecular Substances As Potential Biomarkers For Discrimination Of Gastric Tumor
Jianyong Zhang, Qingjun Gao, Xue Luo, Wenxiong Zhang, Nanpeng Wang & Yiping Wei
Pages: 8587-8594
Published online: 17 Oct 2019
AbstractforInvestigation Of Small Molecular Substances As Potential Biomarkers For Discrimination Of Gastric Tumor | Full Text | References | PDF (4.4 MB)
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Case Report

Article
Primary Pulmonary Lymphoepithelioma-Like Carcinoma Response Favorably To Nivolumab: A Case Report
Zhi-Xin Qiu, Ping Zhou & Ke Wang
Pages: 8595-8600
Published online: 17 Oct 2019
AbstractforPrimary Pulmonary Lymphoepithelioma-Like Carcinoma Response Favorably To Nivolumab: A Case Report | Full Text | References | PDF (3.5 MB)
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Review

Article
Resveratrol As A Natural Regulator Of Autophagy For Prevention And Treatment Of Cancer
Yuanyuan Tian, Wenjing Song, Dan Li, Lu Cai & Yuguang Zhao
Pages: 8601-8609
Published online: 17 Oct 2019
AbstractforResveratrol As A Natural Regulator Of Autophagy For Prevention And Treatment Of Cancer | Full Text | References | PDF (761.5 KB)
  • 86 Views
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Article
Apiosporamide, A 4-hydroxy-2-pyridone Alkaloid, Induces Apoptosis Via PI3K/Akt Signaling Pathway In Osteosarcoma Cells
Yuying Zhang, Qianqian Zhang, Jie Bao, Jintian Huang & Hua Zhang
Pages: 8611-8620
Published online: 21 Oct 2019
AbstractforApiosporamide, A 4-hydroxy-2-pyridone Alkaloid, Induces Apoptosis Via PI3K/Akt Signaling Pathway In Osteosarcoma Cells | Full Text | References | PDF (5.4 MB)
  • 41 Views
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Article
Methyloleanolate Induces Apoptotic And Autophagic Cell Death Via Reactive Oxygen Species Generation And c-Jun N-terminal Kinase Phosphorylation
Myoung Seok Jeong, Ji Hoon Jung, Hyemin Lee, Chang Geun Kim & Sung-Hoon Kim
Pages: 8621-8635
Published online: 23 Oct 2019
AbstractforMethyloleanolate Induces Apoptotic And Autophagic Cell Death Via Reactive Oxygen Species Generation And c-Jun N-terminal Kinase Phosphorylation | Full Text | References | PDF (7.3 MB)
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Article
Nitrogen Permease Regulator-Like-2 Exhibited Anti-Tumor Effects And Enhanced The Sensitivity Of Colorectal Cancer Cells To Oxaliplatin And 5-Fluorouracil
Aiyun Liu, Jiutao Qiao, Liyuan He, Zhangmeng Liu, Jing Chen, Fenghua Pei & Yaju Du
Pages: 8637-8644
Published online: 18 Oct 2019
AbstractforNitrogen Permease Regulator-Like-2 Exhibited Anti-Tumor Effects And Enhanced The Sensitivity Of Colorectal Cancer Cells To Oxaliplatin And 5-Fluorouracil | Full Text | References | PDF (5.5 MB)
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Case Report

Case Report
A Gallbladder Carcinoma Patient With Pseudo-Progressive Remission After Hydrogen Inhalation
Jibing Chen, Feng Mu, Tianyu Lu, Yangyang Ma, Duanming Du & Kecheng Xu
Pages: 8645-8651
Published online: 18 Oct 2019
AbstractforA Gallbladder Carcinoma Patient With Pseudo-Progressive Remission After Hydrogen Inhalation | Full Text | References | PDF (4.1 MB)
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Original Research

Article
Long Noncoding RNA SNHG16 Sponges miR-182-5p And miR-128-3p To Promote Retinoblastoma Cell Migration And Invasion By Targeting LASP1
Lidong Yang, Liyou Zhang, Lu Lu & Yan Wang
Pages: 8653-8662
Published online: 18 Oct 2019
AbstractforLong Noncoding RNA SNHG16 Sponges miR-182-5p And miR-128-3p To Promote Retinoblastoma Cell Migration And Invasion By Targeting LASP1 | Full Text | References | PDF (6.3 MB)
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Article
An Immunoscore System Based On CD3+ And CD8+ Infiltrating Lymphocytes Densities To Predict The Outcome Of Patients With Colorectal Adenocarcinoma
Mouna Trabelsi, Faten Farah, Bechir Zouari, Mohamed Habib Jaafoura & Maher Kharrat
Pages: 8663-8673
Published online: 21 Oct 2019
AbstractforAn Immunoscore System Based On CD3+ And CD8+ Infiltrating Lymphocytes Densities To Predict The Outcome Of Patients With Colorectal Adenocarcinoma | Full Text | References | PDF (4.7 MB)
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Article
S100 Calcium Binding Protein A11 (S100A11) Promotes The Proliferation, Migration And Invasion Of Cervical Cancer Cells, And Activates Wnt/β-Catenin Signaling
Man Meng, Lin Sang & Xiangyu Wang
Pages: 8675-8685
Published online: 22 Oct 2019
AbstractforS100 Calcium Binding Protein A11 (S100A11) Promotes The Proliferation, Migration And Invasion Of Cervical Cancer Cells, And Activates Wnt/β-Catenin Signaling | Full Text | References | PDF (6.3 MB)
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Review

Review Article
Tumor-Associated Macrophages (TAMs): A Critical Activator In Ovarian Cancer Metastasis
Meichen Yin, Jiayu Shen, Shuqian Yu, Jing Fei, Xiaoqing Zhu, Jiayao Zhao, Lingyun Zhai, Annapurna Sadhukhan & Jianwei Zhou
Pages: 8687-8699
Published online: 21 Oct 2019
AbstractforTumor-Associated Macrophages (TAMs): A Critical Activator In Ovarian Cancer Metastasis | Full Text | References | PDF (2.6 MB)
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Original Research

Article
RGS4 Regulates Proliferation And Apoptosis Of NSCLC Cells Via microRNA-16 And Brain-Derived Neurotrophic Factor
Zheng He, Lianhua Yu, Shiyi Luo, Qi Li, Shuhong Huang & Yunhe An
Pages: 8701-8714
Published online: 25 Oct 2019
AbstractforRGS4 Regulates Proliferation And Apoptosis Of NSCLC Cells Via microRNA-16 And Brain-Derived Neurotrophic Factor | Full Text | References | PDF (10.7 MB)
  • 63 Views
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Article
RETRACTED ARTICLE: Overexpression Of ERβ Participates In The Progression Of Liver Cancer Via Inhibiting The Notch Signaling Pathway
Yiping Zhang, Benyi Yi, Xufeng Zhou, Yahua Wu & Lili Wang
Pages: 8715-8724
Published online: 22 Oct 2019
AbstractforRETRACTED ARTICLE: Overexpression Of ERβ Participates In The Progression Of Liver Cancer Via Inhibiting The Notch Signaling Pathway | PDF (5.9 MB)
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Article
LncRNA CASC15 Functions As An Unfavorable Predictor Of Ovarian Cancer Prognosis And Inhibits Tumor Progression Through Regulation Of miR-221/ARID1A Axis
Yin Shi, Shanshan Gao, Ying Zheng, Mukun Yao & Fan Ruan
Pages: 8725-8736
Published online: 23 Oct 2019
AbstractforLncRNA CASC15 Functions As An Unfavorable Predictor Of Ovarian Cancer Prognosis And Inhibits Tumor Progression Through Regulation Of miR-221/ARID1A Axis | Full Text | References | PDF (6.8 MB)
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Article
α-Hederin Increases The Apoptosis Of Cisplatin-Resistant Gastric Cancer Cells By Activating Mitochondrial Pathway In Vivo And Vitro
Yinghui Liu, Hongbo Lei, Jingjing Ma, Huan Deng, Pengzhan He & Weiguo Dong
Pages: 8737-8750
Published online: 23 Oct 2019
Abstractforα-Hederin Increases The Apoptosis Of Cisplatin-Resistant Gastric Cancer Cells By Activating Mitochondrial Pathway In Vivo And Vitro | Full Text | References | PDF (13.9 MB)
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Article
Se-Enriched Cordyceps militaris Inhibits Cell Proliferation, Induces Cell Apoptosis, And Causes G2/M Phase Arrest In Human Non-Small Cell Lung Cancer Cells
Lihua Luo, Ruizhi Ran, Jie Yao, Fang Zhang, Maohui Xing, Min Jin, Lanqing Wang & Tao Zhang
Pages: 8751-8763
Published online: 23 Oct 2019
AbstractforSe-Enriched Cordyceps militaris Inhibits Cell Proliferation, Induces Cell Apoptosis, And Causes G2/M Phase Arrest In Human Non-Small Cell Lung Cancer Cells | Full Text | References | PDF (10.2 MB)
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Case Report

Case Report
Hepatoid Adenocarcinoma Of The Lung Metastasizing To The Gingiva
Chunhua Wang, Guohui Xu, Ge Wu, Zhiming Chen, Zhiyong Sun, Ping Zheng, Yecai Huang, Fuqiang Wang & Xuegang Yang
Pages: 8765-8768
Published online: 23 Oct 2019
AbstractforHepatoid Adenocarcinoma Of The Lung Metastasizing To The Gingiva | Full Text | References | PDF (3 MB)
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Review

Article
Darolutamide For Castration-Resistant Prostate Cancer
Diogo A Bastos & Emmanuel S Antonarakis
Pages: 8769-8777
Published online: 23 Oct 2019
AbstractforDarolutamide For Castration-Resistant Prostate Cancer | Full Text | References | PDF (335.8 KB)
  • 127 Views
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Original Research

Article
Neutrophil-To-Lymphocyte Ratio Predicted Long-Term Chemotherapy Benefits In Stage IIIB-IV Non-Squamous Non-Small Cell Lung Cancer Patients Without Sensitive Mutations
Xing Li, Wei-Hua Zeng, Yu-Qi Zhou, Yan-Ying Ji, Wei-Zhan Li, Li-Yi Zhang, Yue-Fei Guo, Ding-Yun Feng & Tian-Tuo Zhang
Pages: 8779-8787
Published online: 23 Oct 2019
AbstractforNeutrophil-To-Lymphocyte Ratio Predicted Long-Term Chemotherapy Benefits In Stage IIIB-IV Non-Squamous Non-Small Cell Lung Cancer Patients Without Sensitive Mutations | Full Text | References | PDF (3 MB)
  • 26 Views
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Article
Prognostic Values Of Preoperative Serum CEA And CA125 Levels And Nomograms For Young Breast Cancer Patients
Xuan Li, Danian Dai, Bo Chen, Sirong He, Jie Zhang, Chunjie Wen & Bin Wang
Pages: 8789-8800
Published online: 24 Oct 2019
AbstractforPrognostic Values Of Preoperative Serum CEA And CA125 Levels And Nomograms For Young Breast Cancer Patients | Full Text | References | PDF (6.2 MB)
  • 37 Views
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Case Report

Case Report
A Rare Case Of Synchronous Multiple Primary Lung Cancer: Squamous Cell Cancer And Small Cell Lung Cancer
Luxi Jiang, Xiangxin Zheng, Shengchang Wu, Jie Zhang, Guoqing Ru & Yaqing Li
Pages: 8801-8806
Published online: 24 Oct 2019
AbstractforA Rare Case Of Synchronous Multiple Primary Lung Cancer: Squamous Cell Cancer And Small Cell Lung Cancer | Full Text | References | PDF (3.3 MB)
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Corrigendum

Correction
Synergistic Effect Of A Retinoid X Receptor-Selective Ligand Bexarotene And Docetaxel In Prostate Cancer [Corrigendum]
Page: 8807
Published online: 25 Oct 2019
CitationforSynergistic Effect Of A Retinoid X Receptor-Selective Ligand Bexarotene And Docetaxel In Prostate Cancer [Corrigendum] | Full Text | PDF (144.3 KB)
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Original Research

Article
Targeted Toxin Gene Therapy Of Breast Cancer Stem Cells Using CXCR1 Promoter And bFGF 5′UTR
Cobra Moradian & Fatemeh Rahbarizadeh
Pages: 8809-8820
Published online: 25 Oct 2019
AbstractforTargeted Toxin Gene Therapy Of Breast Cancer Stem Cells Using CXCR1 Promoter And bFGF 5′UTR | Full Text | References | PDF (5.7 MB)
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Article
Ganoderan (GDN) Regulates The Growth, Motility And Apoptosis Of Non-Small Cell Lung Cancer Cells Through ERK Signaling Pathway In Vitro And In Vivo
Weifeng Wang, Xiaohui Gou, Hua Xue & Kai Liu
Pages: 8821-8832
Published online: 25 Oct 2019
AbstractforGanoderan (GDN) Regulates The Growth, Motility And Apoptosis Of Non-Small Cell Lung Cancer Cells Through ERK Signaling Pathway In Vitro And In Vivo | Full Text | References | PDF (9.5 MB)
  • 63 Views
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Article
The Prognostic Values Of Circulating Tumor Cells In Lung Carcinoma: An Analysis On 98 Chinese Patients
Min-Hua Tan, Zhi-Geng Zhong, Pan-Long Chen & Yi-Xing Zhou
Pages: 8833-8840
Published online: 25 Oct 2019
AbstractforThe Prognostic Values Of Circulating Tumor Cells In Lung Carcinoma: An Analysis On 98 Chinese Patients | Full Text | References | PDF (7 MB)
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Article
LncRNA NORAD Promotes Proliferation And Inhibits Apoptosis Of Gastric Cancer By Regulating miR-214/Akt/mTOR Axis
Wei Tao, Yajun Li, Meng Zhu, Cheng Li & Peng Li
Pages: 8841-8851
Published online: 30 Oct 2019
AbstractforLncRNA NORAD Promotes Proliferation And Inhibits Apoptosis Of Gastric Cancer By Regulating miR-214/Akt/mTOR Axis | Full Text | References | PDF (11.9 MB)
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Article
Long Non-Coding RNA CDKN2B-AS1 Facilitates Laryngeal Squamous Cell Cancer Through Regulating miR-497/CDK6 Pathway
Xiangyan Cui, Tingting Yu, Jing Shang, Dong Xiao & Xin Wang
Pages: 8853-8862
Published online: 29 Oct 2019
AbstractforLong Non-Coding RNA CDKN2B-AS1 Facilitates Laryngeal Squamous Cell Cancer Through Regulating miR-497/CDK6 Pathway | Full Text | References | PDF (7.2 MB)
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Article
Clinicopathological Characteristics And EGFR-TKIs Efficacies In Lung Squamous Cell Carcinoma Patients Harboring An EGFR Sensitizing Mutation
Shaozhang Zhou, Huilin Wang, Wei Jiang & Qitao Yu
Pages: 8863-8871
Published online: 30 Oct 2019
AbstractforClinicopathological Characteristics And EGFR-TKIs Efficacies In Lung Squamous Cell Carcinoma Patients Harboring An EGFR Sensitizing Mutation | Full Text | References | PDF (2.2 MB)
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Case Report

Case Report
Hyperprogressive Disease In Cervical Small Cell Carcinoma Treated By Immune Checkpoint Inhibitor
Zihan Xu, Liying Chen, Linpeng Zheng, Qiao Yang, Mingjing Chen, Jianmin Wang, Guangkuo Zhu, Zhengtang Chen & Jianguo Sun
Pages: 8873-8877
Published online: 30 Oct 2019
AbstractforHyperprogressive Disease In Cervical Small Cell Carcinoma Treated By Immune Checkpoint Inhibitor | Full Text | References | PDF (3.4 MB)
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Original Research

Article
RETRACTED ARTICLE: The Long Non-Coding RNA SBF2-AS1 Exerts Oncogenic Functions In Gastric Cancer By Targeting The miR-302b-3p/E2F Transcription Factor 3 Axis
Chaojie Liang, Chaosen Yue, Chaowei Liang, Hua Ge, Zhigang Wei, Guangming Li, Jixiang Wu, He Huang & Jiansheng Guo
Pages: 8879-8893
Published online: 30 Oct 2019
AbstractforRETRACTED ARTICLE: The Long Non-Coding RNA SBF2-AS1 Exerts Oncogenic Functions In Gastric Cancer By Targeting The miR-302b-3p/E2F Transcription Factor 3 Axis | PDF (10.9 MB)
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Article
TIMP1 Is A Potential Key Gene Associated With The Pathogenesis And Prognosis Of Ulcerative Colitis-Associated Colorectal Cancer
Ru Huang, Kaijing Wang, Lei Gao & Wei Gao
Pages: 8895-8904
Published online: 30 Oct 2019
AbstractforTIMP1 Is A Potential Key Gene Associated With The Pathogenesis And Prognosis Of Ulcerative Colitis-Associated Colorectal Cancer | Full Text | References | PDF (4.2 MB)
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Article
MicroRNA-186-5p Inhibits Proliferation And Metastasis Of Esophageal Cancer By Mediating HOXA9
Changqin Xu, Bin Li, Shulei Zhao, Bingjie Jin, Ruzhen Jia, Jian Ge & Hongwei Xu
Pages: 8905-8914
Published online: 30 Oct 2019
AbstractforMicroRNA-186-5p Inhibits Proliferation And Metastasis Of Esophageal Cancer By Mediating HOXA9 | Full Text | References | PDF (4.9 MB)
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Article
EFEMP2 Inhibits Breast Cancer Invasion And Metastasis In Vitro And In Vivo
Ning Kang, Jijun Zhou, Jia Xu, Dongsheng Zhou & Weichen Shi
Pages: 8915-8933
Published online: 30 Oct 2019
AbstractforEFEMP2 Inhibits Breast Cancer Invasion And Metastasis In Vitro And In Vivo | Full Text | References | PDF (18.2 MB)
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Article
RETRACTED ARTICLE: MicroRNA-139-3p Inhibits The Growth And Metastasis Of Ovarian Cancer By Inhibiting ELAVL1
Fang Xue, Qi Rong Li, Yan Hua Xu & Hai Bin Zhou
Pages: 8935-8945
Published online: 05 Nov 2019
AbstractforRETRACTED ARTICLE: MicroRNA-139-3p Inhibits The Growth And Metastasis Of Ovarian Cancer By Inhibiting ELAVL1 | PDF (7.6 MB)
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Article
LOXL 2 Promotes The Epithelial–Mesenchymal Transition And Malignant Progression Of Cervical Cancer
Jing Tian, He-Xi Sun, Ying-Chun Li, Li Jiang, Shan-Ling Zhang & Quan Hao
Pages: 8947-8954
Published online: 30 Oct 2019
AbstractforLOXL 2 Promotes The Epithelial–Mesenchymal Transition And Malignant Progression Of Cervical Cancer | Full Text | References | PDF (6.7 MB)
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Case Report

Case Report
Coexistence Of A Huge Venous Thromboembolism And Bleeding Tendency In Cytokine Release Syndrome During CAR-T Therapy
Haiyan Liu, Ye Yang, Jie Jiang, Xinfeng Wang, Chenlu Zhang, Yijing Jiang, Lemin Hong & Hongming Huang
Pages: 8955-8960
Published online: 30 Oct 2019
AbstractforCoexistence Of A Huge Venous Thromboembolism And Bleeding Tendency In Cytokine Release Syndrome During CAR-T Therapy | Full Text | References | PDF (3.1 MB)
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Original Research

Article
Key Genes And Pathways Controlled By E2F1 In Human Castration-Resistant Prostate Cancer Cells
Qingniao Zhou, Chengbang Wang, Yuanyuan Zhu, Qunying Wu, Yonghua Jiang, Yuanjie Huang & Yanling Hu
Pages: 8961-8976
Published online: 31 Oct 2019
AbstractforKey Genes And Pathways Controlled By E2F1 In Human Castration-Resistant Prostate Cancer Cells | Full Text | References | PDF (13 MB)
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Article
Bag-1 Silence Sensitizes Non-Small Cell Lung Cancer Cells To Cisplatin Through Multiple Gene Pathways
Jiling Lv, Fang Zhang, Congying Zhai, Gejin Wang & Yan Qu
Pages: 8977-8989
Published online: 31 Oct 2019
AbstractforBag-1 Silence Sensitizes Non-Small Cell Lung Cancer Cells To Cisplatin Through Multiple Gene Pathways | Full Text | References | PDF (10.8 MB)
  • 38 Views
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Article
RETRACTED ARTICLE: Long Noncoding RNA NEAT1 Promotes Cell Proliferation And Invasion And Suppresses Apoptosis In Hepatocellular Carcinoma By Regulating miRNA-22-3p/akt2 In Vitro And In Vivo
Xichang Zhou, Xiang Wang, Yizhou Zhou, Long Cheng, Youwei Zhang & Yangmei Zhang
Pages: 8991-9004
Published online: 31 Oct 2019
AbstractforRETRACTED ARTICLE: Long Noncoding RNA NEAT1 Promotes Cell Proliferation And Invasion And Suppresses Apoptosis In Hepatocellular Carcinoma By Regulating miRNA-22-3p/akt2 In Vitro And In Vivo | PDF (9.6 MB)
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Article
RETRACTED ARTICLE: MicroRNA-503 Inhibits Non-Small Cell Lung Cancer Progression By Targeting PDK1/PI3K/AKT Pathway
Yingying Wei, Yuanfan Liao, Yu Deng, Yukun Zu, Bo Zhao & Fan Li
Pages: 9005-9016
Published online: 31 Oct 2019
AbstractforRETRACTED ARTICLE: MicroRNA-503 Inhibits Non-Small Cell Lung Cancer Progression By Targeting PDK1/PI3K/AKT Pathway | PDF (9.8 MB)
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Article
Long Non-Coding RNA CASC9 And HIF-1α Form A Positive Feedback Loop To Facilitate Cell Proliferation And Metastasis In Lung Cancer
Yuxing Jin, Huikang Xie, Liang Duan, Deping Zhao, Jiaan Ding & Gening Jiang
Pages: 9017-9027
Published online: 31 Oct 2019
AbstractforLong Non-Coding RNA CASC9 And HIF-1α Form A Positive Feedback Loop To Facilitate Cell Proliferation And Metastasis In Lung Cancer | Full Text | References | PDF (9.6 MB)
  • 26 Views
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Article
Receptor-Interacting Protein Kinase 1 Promotes Cholangiocarcinoma Proliferation And Lymphangiogenesis Through The Activation Protein 1 Pathway
Cheng-Zong Li, Yu-Xiang Lin, Tian-Cong Huang, Jun-Yong Pan & Gao-Xiong Wang
Pages: 9029-9040
Published online: 01 Nov 2019
AbstractforReceptor-Interacting Protein Kinase 1 Promotes Cholangiocarcinoma Proliferation And Lymphangiogenesis Through The Activation Protein 1 Pathway | Full Text | References | PDF (12.9 MB)
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Article
CARF, As An Oncogene, Promotes Colorectal Cancer Stemness By Activating ERBB Signaling Pathway
Weiyi Dong, Zheng Cao, Yanmin Pang, Teng Feng & Hongtao Tian
Pages: 9041-9051
Published online: 01 Nov 2019
AbstractforCARF, As An Oncogene, Promotes Colorectal Cancer Stemness By Activating ERBB Signaling Pathway | Full Text | References | PDF (7.9 MB)
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Article
miR-522-3p Promotes Osteosarcoma Cell Growth By Regulating Glucose Uptake And GLUT1 Expression
Rong Chen, Jiasheng Lin, Wei Yan & Dongdong Chen
Pages: 9053-9058
Published online: 01 Nov 2019
AbstractformiR-522-3p Promotes Osteosarcoma Cell Growth By Regulating Glucose Uptake And GLUT1 Expression | Full Text | References | PDF (3.2 MB)
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Article
Supervised Machine Learning Predictive Analytics For Triple-Negative Breast Cancer Death Outcomes
Yucan Xu, Lingsha Ju, Jianhua Tong, Chengmao Zhou & Jianjun Yang
Pages: 9059-9067
Published online: 01 Nov 2019
AbstractforSupervised Machine Learning Predictive Analytics For Triple-Negative Breast Cancer Death Outcomes | Full Text | References | PDF (2.7 MB)
  • 299 Views
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Article
FKBP14 Promotes The Proliferation And Migration Of Colon Carcinoma Cells Through Targeting IL-6/STAT3 Signaling Pathway
Leilei Yang, Ruili Zhang, Jie Yang, Tienan Bi & Shenkang Zhou
Pages: 9069-9076
Published online: 01 Nov 2019
AbstractforFKBP14 Promotes The Proliferation And Migration Of Colon Carcinoma Cells Through Targeting IL-6/STAT3 Signaling Pathway | Full Text | References | PDF (4.7 MB)
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Article
Individualized Prediction Of Metastatic Involvement Of Lymph Nodes Posterior To The Right Recurrent Laryngeal Nerve In Papillary Thyroid Carcinoma
Jiang Zhu, Rui Huang, DaiXing Hu, Yi Dou, HaoYu Ren, ZhiXin Yang, Chang Deng, Wei Xiong, Denghui Wang, Yu Mao, Xuesong Li & XinLiang Su
Pages: 9077-9084
Published online: 04 Nov 2019
AbstractforIndividualized Prediction Of Metastatic Involvement Of Lymph Nodes Posterior To The Right Recurrent Laryngeal Nerve In Papillary Thyroid Carcinoma | Full Text | References | PDF (2.1 MB)
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Case Report

Case Report
Genomic Alterations In Primary Cardiac Diffuse Large B Cell Lymphoma: A Case Report And Literature Review
Jinjing Zhang, Xuyong Lin, Yan Li & Rui Zhang
Pages: 9085-9092
Published online: 04 Nov 2019
AbstractforGenomic Alterations In Primary Cardiac Diffuse Large B Cell Lymphoma: A Case Report And Literature Review | Full Text | References | PDF (2 MB)
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Original Research

Article
Diosgenin Suppresses Cholangiocarcinoma Cells Via Inducing Cell Cycle Arrest And Mitochondria-Mediated Apoptosis
Xiao-Mei Mao, Pan Zhou, Si-Yang Li, Xiao-Yun Zhang, Jin-Xing Shen, Qing-Xi Chen, Jiang-Xing Zhuang & Dong-Yan Shen
Pages: 9093-9104
Published online: 04 Nov 2019
AbstractforDiosgenin Suppresses Cholangiocarcinoma Cells Via Inducing Cell Cycle Arrest And Mitochondria-Mediated Apoptosis | Full Text | References | PDF (9.1 MB)
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Review

Review Article
Checkpoint CD47 Function On Tumor Metastasis And Immune Therapy
Shu Lian, Xiaodong Xie, Yusheng Lu & Lee Jia
Pages: 9105-9114
Published online: 04 Nov 2019
AbstractforCheckpoint CD47 Function On Tumor Metastasis And Immune Therapy | Full Text | References | PDF (2.3 MB)
  • 69 Views
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Corrigendum

Correction
Circulating Serum Exosomal aHIF Is A Novel Prognostic Predictor For Epithelial Ovarian Cancer [Corrigendum]
Page: 9115
Published online: 05 Nov 2019
CitationforCirculating Serum Exosomal aHIF Is A Novel Prognostic Predictor For Epithelial Ovarian Cancer [Corrigendum] | Full Text | PDF (677.8 KB)
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Original Research

Article
Expression And Biological Interaction Network Of RHOC For Hepatic Carcinoma With Metastasis In PBMC Samples
Yanting Shen, Lu Bu, Rui Li, Zhenzhu Chen, Fei Tian & Qinyu Ge
Pages: 9117-9128
Published online: 05 Nov 2019
AbstractforExpression And Biological Interaction Network Of RHOC For Hepatic Carcinoma With Metastasis In PBMC Samples | Full Text | References | PDF (9.3 MB)
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Article
GLUT-1 siRNA Enhances Radiosensitization Of Laryngeal Cancer Stem Cells Via Enhanced DNA Damage, Cell Cycle Redistribution, And Promotion Of Apoptosis In Vitro And In Vivo
Jiang-Tao Zhong, Qi Yu, Shui-Hong Zhou, Er Yu, Yang-Yang Bao, Zhong-Jie Lu & Jun Fan
Pages: 9129-9142
Published online: 05 Nov 2019
AbstractforGLUT-1 siRNA Enhances Radiosensitization Of Laryngeal Cancer Stem Cells Via Enhanced DNA Damage, Cell Cycle Redistribution, And Promotion Of Apoptosis In Vitro And In Vivo | Full Text | References | PDF (7.8 MB)
  • 47 Views
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Article
RNA m6A Methyltransferase METTL3 Promotes The Growth Of Prostate Cancer By Regulating Hedgehog Pathway
Jiarong Cai, Fei Yang, Hailun Zhan, Jie Situ, Wenbiao Li, Yunhua Mao & Yun Luo
Pages: 9143-9152
Published online: 05 Nov 2019
AbstractforRNA m6A Methyltransferase METTL3 Promotes The Growth Of Prostate Cancer By Regulating Hedgehog Pathway | Full Text | References | PDF (5.4 MB)
  • 51 Views
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Article
RETRACTED ARTICLE: Estrogen Receptor Beta Inhibits The Proliferation, Migration, And Angiogenesis Of Gastric Cancer Cells Through Inhibiting Nuclear Factor-Kappa B Signaling
Yiping Zhang, Yahua Wu, Xufeng Zhou, Benyi Yi & Lili Wang
Pages: 9153-9164
Published online: 05 Nov 2019
AbstractforRETRACTED ARTICLE: Estrogen Receptor Beta Inhibits The Proliferation, Migration, And Angiogenesis Of Gastric Cancer Cells Through Inhibiting Nuclear Factor-Kappa B Signaling | PDF (8 MB)
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Article
Targeting ZEB2 By microRNA-129 In Non-Small Cell Lung Cancer Suppresses Cell Proliferation, Invasion And Migration Via Regulating Wnt/β-Catenin Signaling Pathway And Epithelial–Mesenchymal Transition
Xingtao Li, Chunhong Li, Hongmei Bi, Shufang Bai, Lin Zhao, Jing Zhang & Chunhui Qi
Pages: 9165-9175
Published online: 05 Nov 2019
AbstractforTargeting ZEB2 By microRNA-129 In Non-Small Cell Lung Cancer Suppresses Cell Proliferation, Invasion And Migration Via Regulating Wnt/β-Catenin Signaling Pathway And Epithelial–Mesenchymal Transition | Full Text | References | PDF (7.4 MB)
  • 31 Views
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Article
RETRACTED ARTICLE: MicroRNA-769-5p Promotes The Growth Of Glioma Cells By Targeting Lysine Methyltransferase 2A
Mingze Chang, Peng Yan, Bei Zhang, Gejuan Zhang, Juanhong Wang, Hanming Ge, Nannan Han, Chengxue Du, Wenzhen Shi & Ye Tian
Pages: 9177-9187
Published online: 05 Nov 2019
AbstractforRETRACTED ARTICLE: MicroRNA-769-5p Promotes The Growth Of Glioma Cells By Targeting Lysine Methyltransferase 2A | PDF (9.3 MB)
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Article
RASSF6 Is Downregulated In Human Bladder Cancers And Regulates Doxorubicin Sensitivity And Mitochondrial Membrane Potential Via The Hippo Signaling Pathway
Shutao Tan, Xiaobo Bian, Bin Wu & Xiaonan Chen
Pages: 9189-9200
Published online: 05 Nov 2019
AbstractforRASSF6 Is Downregulated In Human Bladder Cancers And Regulates Doxorubicin Sensitivity And Mitochondrial Membrane Potential Via The Hippo Signaling Pathway | Full Text | References | PDF (9.7 MB)
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Article
CLK3 Is A Direct Target Of miR-144 And Contributes To Aggressive Progression In Hepatocellular Carcinoma
Hua Li, Xichun Cui, Qiuyue Hu, Xiaolong Chen & Pengli Zhou
Pages: 9201-9213
Published online: 05 Nov 2019
AbstractforCLK3 Is A Direct Target Of miR-144 And Contributes To Aggressive Progression In Hepatocellular Carcinoma | Full Text | References | PDF (11.4 MB)
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Article
LncRNA CCAT1 Promotes Colorectal Cancer Tumorigenesis Via A miR-181b-5p/TUSC3 Axis
Si Chen, Yan Liu, Yuanyuan Wang & Zhaoping Xue
Pages: 9215-9225
Published online: 05 Nov 2019
AbstractforLncRNA CCAT1 Promotes Colorectal Cancer Tumorigenesis Via A miR-181b-5p/TUSC3 Axis | Full Text | References | PDF (7.2 MB)
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Article
HGF/MET Regulated Epithelial-Mesenchymal Transitions And Metastasis By FOSL2 In Non-Small Cell Lung Cancer
Jun Yin, Weimin Hu, Wenfan Fu, Lu Dai, Zeyong Jiang, Shengpeng Zhong, Boyun Deng & Jian Zhao
Pages: 9227-9237
Published online: 05 Nov 2019
AbstractforHGF/MET Regulated Epithelial-Mesenchymal Transitions And Metastasis By FOSL2 In Non-Small Cell Lung Cancer | Full Text | References | PDF (5.8 MB)
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Article
SPOP Regulates The Biological Mechanism Of Ovarian Cancer Cells Through The Hh Signaling Pathway
Yanxi Li, Qiubo Yu, Ruohan Li, Jing Luo, Dong Yuan, Jiao Song, Yixuan Sun, Tengfei Long & Zhu Yang
Pages: 9239-9248
Published online: 06 Nov 2019
AbstractforSPOP Regulates The Biological Mechanism Of Ovarian Cancer Cells Through The Hh Signaling Pathway | Full Text | References | PDF (6.9 MB)
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Article
Clinical Significance And Integrative Analysis Of Kinesin Family Member 18B In Lung Adenocarcinoma
Yonglong Zhong, Lingyu Jiang, Xiaomao Long, Yifan Zhou, Shen Deng, Hui Lin & Xiangwei Li
Pages: 9249-9264
Published online: 05 Nov 2019
AbstractforClinical Significance And Integrative Analysis Of Kinesin Family Member 18B In Lung Adenocarcinoma | Full Text | References | PDF (13.6 MB)
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Article
Identification Of Actionable Genetic Targets In Primary Cardiac Sarcomas
Carmen Salvador-Coloma, María Saigí, Roberto Díaz-Beveridge, Rosa María Penín, María Pané-Foix, Empar Mayordomo, Marcos Melián, Mona Schuler, Xavier García Del Muro & Jaime Font de Mora
Pages: 9265-9275
Published online: 07 Nov 2019
AbstractforIdentification Of Actionable Genetic Targets In Primary Cardiac Sarcomas | Full Text | References | PDF (3.9 MB)
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Article
RETRACTED ARTICLE: LINC00958 Promotes The Malignancy Of Nasopharyngeal Carcinoma By Sponging microRNA-625 And Thus Upregulating NUAK1
Meijuan Chen, Zhina Xu, Yingyao Zhang & Xiujuan Zhang
Pages: 9277-9290
Published online: 06 Nov 2019
AbstractforRETRACTED ARTICLE: LINC00958 Promotes The Malignancy Of Nasopharyngeal Carcinoma By Sponging microRNA-625 And Thus Upregulating NUAK1 | PDF (9.4 MB)
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Article
Emerging Roles Of hsa-circ-0046600 Targeting The miR-640/HIF-1α Signalling Pathway In The Progression Of HCC
Zhensheng Zhai, Qiang Fu, Chuanjiang Liu, Xu Zhang, Pengchong Jia, Peng Xia, Pan Liu, Shixiu Liao, Tao Qin & Hongwei Zhang
Pages: 9291-9302
Published online: 06 Nov 2019
AbstractforEmerging Roles Of hsa-circ-0046600 Targeting The miR-640/HIF-1α Signalling Pathway In The Progression Of HCC | Full Text | References | PDF (10 MB)
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Case Report

Case Report
FGFR2-BICC1: A Subtype Of FGFR2 Oncogenic Fusion Variant In Cholangiocarcinoma And The Response To Sorafenib
Xihui Ying, Jianfei Tu, Wenxian Wang, Xingliang Li, Chunwei Xu & Jiansong Ji
Pages: 9303-9307
Published online: 06 Nov 2019
AbstractforFGFR2-BICC1: A Subtype Of FGFR2 Oncogenic Fusion Variant In Cholangiocarcinoma And The Response To Sorafenib | Full Text | References | PDF (4.6 MB)
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Original Research

Article
Long Non-Coding RNA STARD13-AS Suppresses Cell Proliferation And Metastasis In Colorectal Cancer
Bin Yang, Sheng-Ning Zhou, Jia-Nan Tan, Jing Huang, Zhi-Tao Chen, Guang-Yu Zhong & Fang-Hai Han
Pages: 9309-9318
Published online: 06 Nov 2019
AbstractforLong Non-Coding RNA STARD13-AS Suppresses Cell Proliferation And Metastasis In Colorectal Cancer | Full Text | References | PDF (2.1 MB)
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Article
BANCR Regulates The Cell Invasion And Migration In Esophageal Squamous Cell Carcinoma Through Wnt/β-Catenin Signaling Pathway
Quan Chen, Yiming Zheng, Bingbing Wu, Xia Chen, Fei Sun, Pengfei Ge & Pengcheng Wang
Pages: 9319-9327
Published online: 06 Nov 2019
AbstractforBANCR Regulates The Cell Invasion And Migration In Esophageal Squamous Cell Carcinoma Through Wnt/β-Catenin Signaling Pathway | Full Text | References | PDF (5.2 MB)
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Article
Serum Derived Exosomes From Pancreatic Cancer Patients Promoted Metastasis: An iTRAQ-Based Proteomic Analysis
Puxian Tang, Lianyuan Tao, Chunhui Yuan, Lingfu Zhang & Dianrong Xiu
Pages: 9329-9339
Published online: 06 Nov 2019
AbstractforSerum Derived Exosomes From Pancreatic Cancer Patients Promoted Metastasis: An iTRAQ-Based Proteomic Analysis | Full Text | References | PDF (7.8 MB)
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Article
CD137 Co-Stimulation Improves The Antitumor Effect Of LMP1-Specific Chimeric Antigen Receptor T Cells In Vitro And In Vivo
Xiaojun Tang, Qi Tang, Yuan Mao, Xiaochen Huang, Lizhou Jia, Jin Zhu & Zhenqing Feng
Pages: 9341-9350
Published online: 07 Nov 2019
AbstractforCD137 Co-Stimulation Improves The Antitumor Effect Of LMP1-Specific Chimeric Antigen Receptor T Cells In Vitro And In Vivo | Full Text | References | PDF (2.3 MB)
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Perspectives

Review Article
Labyrinthin, The Tumor Marker Recognized By MCA 44-3A6: A Case For Pan-Tumor Markers As Targets To Treat Cancer
James A Radosevich & Michael Babich
Pages: 9351-9354
Published online: 06 Nov 2019
AbstractforLabyrinthin, The Tumor Marker Recognized By MCA 44-3A6: A Case For Pan-Tumor Markers As Targets To Treat Cancer | Full Text | References | PDF (926.4 KB)
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Original Research

Article
Tanshinone IIA Reverses Gefitinib-Resistance In Human Non-Small-Cell Lung Cancer Via Regulation Of VEGFR/Akt Pathway
Rui Wang, Zhilin Luo, Hong Zhang & Tianhu Wang
Pages: 9355-9365
Published online: 07 Nov 2019
AbstractforTanshinone IIA Reverses Gefitinib-Resistance In Human Non-Small-Cell Lung Cancer Via Regulation Of VEGFR/Akt Pathway | Full Text | References | PDF (2.6 MB)
  • 108 Views
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Article
Linc00511 Indicates A Poor Prognosis Of Liver Hepatocellular Carcinoma
Pingan Hu, Huxiao Cui, Ting Lei, Siqiao Li, Erhui Mai & Fuxin Jia
Pages: 9367-9376
Published online: 08 Nov 2019
AbstractforLinc00511 Indicates A Poor Prognosis Of Liver Hepatocellular Carcinoma | Full Text | References | PDF (8.1 MB)
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Article
The hERG1 Potassium Channel Behaves As Prognostic Factor In Gastric Dysplasia Endoscopic Samples
Elena Lastraioli, Maria Raffaella Romoli, Jessica Iorio, Tiziano Lottini, Mariella Chiudinelli, Maria Bencivenga, Carla Vindigni, Anna Tomezzoli, Giovanni De Manzoni, Bruno Compagnoni, Ilaria Manzi, Luca Messerini, Luca Saragoni, Annarosa Arcangeli & On behalf of Gruppo Italiano di Ricerca Cancro Gastrico (GIRCG)
Pages: 9377-9384
Published online: 07 Nov 2019
AbstractforThe hERG1 Potassium Channel Behaves As Prognostic Factor In Gastric Dysplasia Endoscopic Samples | Full Text | References | PDF (4.3 MB)
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Article
The Prognostic Significance Of JMJD3 In Primary Sarcomatoid Carcinoma Of The Lung, A Rare Subtype Of Lung Cancer
Shuman Li, Li Jiang, Qingmei He, Weidong Wei, Yun Wang, Xinke Zhang, Jun Liu, Keming Chen, Jiewei Chen & Dan Xie
Pages: 9385-9393
Published online: 07 Nov 2019
AbstractforThe Prognostic Significance Of JMJD3 In Primary Sarcomatoid Carcinoma Of The Lung, A Rare Subtype Of Lung Cancer | Full Text | References | PDF (5.7 MB)
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Article
DNA-PKcs Mediates An Epithelial-Mesenchymal Transition Process Promoting Cutaneous Squamous Cell Carcinoma Invasion And Metastasis By Targeting The TGF-β1/Smad Signaling Pathway
Juan Zhang, Hui Jiang, Dan Xu, Wen-Juan Wu, Hong-Duo Chen & Li He
Pages: 9395-9405
Published online: 07 Nov 2019
AbstractforDNA-PKcs Mediates An Epithelial-Mesenchymal Transition Process Promoting Cutaneous Squamous Cell Carcinoma Invasion And Metastasis By Targeting The TGF-β1/Smad Signaling Pathway | Full Text | References | PDF (9 MB)
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Article
Long Non-Coding RNA HOXA-AS2 Enhances The Malignant Biological Behaviors In Glioma By Epigenetically Regulating RND3 Expression
Lixin Wu, Xuqiang Zhu, Zhenyu Song, Di Chen, Mengguo Guo, Junxin Liang, Daling Ding, Weiguang Wang & Dongming Yan
Pages: 9407-9419
Published online: 07 Nov 2019
AbstractforLong Non-Coding RNA HOXA-AS2 Enhances The Malignant Biological Behaviors In Glioma By Epigenetically Regulating RND3 Expression | Full Text | References | PDF (10.1 MB)
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Article
Downregulation Of microRNA-133b And Its Clinical Value In Non-Small Cell Lung Cancer
Guan-yu Chen & Lin Ruan
Pages: 9421-9434
Published online: 07 Nov 2019
AbstractforDownregulation Of microRNA-133b And Its Clinical Value In Non-Small Cell Lung Cancer | Full Text | References | PDF (14.3 MB)
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Article
Gain-Of-Function E76K-Mutant SHP2 Promotes Cell Proliferation, Metastasis, And Tumor Growth In Glioblastoma Through Activation Of The ERK/CREB Pathway
Fan Yang, Mo Xu, Shiqing Wang, Le Song, Dandan Yu, Yao Li, Rui Cao, Zhang Xiong, Zhijun Chen, Qian Zhang, Bing Zhao & Siying Wang
Pages: 9435-9447
Published online: 07 Nov 2019
AbstractforGain-Of-Function E76K-Mutant SHP2 Promotes Cell Proliferation, Metastasis, And Tumor Growth In Glioblastoma Through Activation Of The ERK/CREB Pathway | Full Text | References | PDF (8.9 MB)
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Article
miR-214-3p inhibits epithelial-to-mesenchymal transition and metastasis of endometrial cancer cells by targeting TWIST1
Yuan-Yuan Fang, Ming-Rong Tan, Jian Zhou, Li Liang, Xiao-Yun Liu, Kun Zhao & Er-Chen Bao
Pages: 9449-9458
Published online: 18 Nov 2019
AbstractformiR-214-3p inhibits epithelial-to-mesenchymal transition and metastasis of endometrial cancer cells by targeting TWIST1 | Full Text | References | PDF (2 MB)
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Review

Review Article
The Role Of Circulating Tumor DNA In Therapeutic Resistance
Chenxin Xu, Haixia Cao, Chen Shi & Jifeng Feng
Pages: 9459-9471
Published online: 08 Nov 2019
AbstractforThe Role Of Circulating Tumor DNA In Therapeutic Resistance | Full Text | References | PDF (401.3 KB)
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Original Research

Article
Effects Of Adenosine On Apoptosis Of Ovarian Cancer A2780 Cells Via ROS And Caspase Pathways
Bing Xia & Jing Wang
Pages: 9473-9480
Published online: 08 Nov 2019
AbstractforEffects Of Adenosine On Apoptosis Of Ovarian Cancer A2780 Cells Via ROS And Caspase Pathways | Full Text | References | PDF (4.7 MB)
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Article
Hydrocortisone Suppresses Early Paraneoplastic Inflammation And Angiogenesis To Attenuate Early Hepatocellular Carcinoma Progression In Rats
Xiaolong Liu, Haiyan Cui, Hongling Niu, Liping Wang, Xiangzhi Li, Jingbo Sun, Qingzhu Wei, Jianghui Dong, Lixin Liu & Cory J Xian
Pages: 9481-9493
Published online: 08 Nov 2019
AbstractforHydrocortisone Suppresses Early Paraneoplastic Inflammation And Angiogenesis To Attenuate Early Hepatocellular Carcinoma Progression In Rats | Full Text | References | PDF (6.2 MB)
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Article
Association Of Initial Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors Treatment And EGFR Exon 19 Deletion With Frequency Of The T790M Mutation In Non-Small Cell Lung Cancer Patients After Resistance To First-Line Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors
Wen Gao, Jing He, Shi-Dai Jin, Jing Xu, Tong-Fu Yu, Wei Wang, Quan Zhu, Hui Dai, Hao Wu, Yi-Qian Liu, Yong-Qian Shu & Ren-Hua Guo
Pages: 9495-9504
Published online: 08 Nov 2019
AbstractforAssociation Of Initial Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors Treatment And EGFR Exon 19 Deletion With Frequency Of The T790M Mutation In Non-Small Cell Lung Cancer Patients After Resistance To First-Line Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors | Full Text | References | PDF (568.7 KB)
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Article
Biomarkers Reflecting The Destruction Of The Blood-Brain Barrier Are Valuable In Predicting The Risk Of Lymphomas With Central Nervous System Involvement
Wenjun Yu, Mengya Si, Li Li, Ping He, Zhiqiang Fan, Qiaoxin Zhang & Xiaoyang Jiao
Pages: 9505-9512
Published online: 11 Nov 2019
AbstractforBiomarkers Reflecting The Destruction Of The Blood-Brain Barrier Are Valuable In Predicting The Risk Of Lymphomas With Central Nervous System Involvement | Full Text | References | PDF (453.6 KB)
  • 31 Views
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Article
RETRACTED ARTICLE: miR-152-3p Sensitizes Glioblastoma Cells Towards Cisplatin Via Regulation Of SOS1
Meihua Wang, Qi Wu, Mingming Fang, Wu Huang & Hong Zhu
Pages: 9513-9525
Published online: 11 Nov 2019
AbstractforRETRACTED ARTICLE: miR-152-3p Sensitizes Glioblastoma Cells Towards Cisplatin Via Regulation Of SOS1 | PDF (7.4 MB)
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Review

Review Article
Blocking TGF-β Signaling To Enhance The Efficacy Of Immune Checkpoint Inhibitor
Xianguang Bai, Ming Yi, Ying Jiao, Qian Chu & Kongming Wu
Pages: 9527-9538
Published online: 11 Nov 2019
AbstractforBlocking TGF-β Signaling To Enhance The Efficacy Of Immune Checkpoint Inhibitor | Full Text | References | PDF (2.8 MB)
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Original Research

Article
circ_0003418 Inhibits Tumorigenesis And Cisplatin Chemoresistance Through Wnt/β-Catenin Pathway In Hepatocellular Carcinoma
Hang Chen, Shan Liu, Molin Li, Ping Huang & Xiaoping Li
Pages: 9539-9549
Published online: 11 Nov 2019
Abstractforcirc_0003418 Inhibits Tumorigenesis And Cisplatin Chemoresistance Through Wnt/β-Catenin Pathway In Hepatocellular Carcinoma | Full Text | References | PDF (12.4 MB)
  • 29 Views
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Case Report

Case Report
Radiologic Complete Response In Lung Adenocarcinoma With Symptomatic Brain Metastasis After Systematic Therapy: A Case Study
Jianxin Chen, Junhui Wang, Qinhong Zheng, Meiling Weng & Xilin Wu
Pages: 9551-9557
Published online: 11 Nov 2019
AbstractforRadiologic Complete Response In Lung Adenocarcinoma With Symptomatic Brain Metastasis After Systematic Therapy: A Case Study | Full Text | References | PDF (6.1 MB)
  • 22 Views
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Original Research

Article
The Prognostic Significance Of Pretreatment Albumin/alkaline Phosphatase Ratio In Patients With Stage IB-IIA Cervical Cancer
Can Zhang, Yong Li, Rui Ji, Weiling Zhang, Chenfei Zhang, Youli Dan, Hongyan Qian & Aiqin He
Pages: 9559-9568
Published online: 12 Nov 2019
AbstractforThe Prognostic Significance Of Pretreatment Albumin/alkaline Phosphatase Ratio In Patients With Stage IB-IIA Cervical Cancer | Full Text | References | PDF (5.2 MB)
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Corrigendum

Correction
Long Non-Coding RNA CASC2 Serves As A ceRNA Of microRNA-21 To Promote PDCD4 Expression In Oral Squamous Cell Carcinoma [Corrigendum]
Page: 9569
Published online: 13 Nov 2019
CitationforLong Non-Coding RNA CASC2 Serves As A ceRNA Of microRNA-21 To Promote PDCD4 Expression In Oral Squamous Cell Carcinoma [Corrigendum] | Full Text | PDF (147 KB)
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Original Research

Article
miR-19a Is Involved In Progression And Malignancy Of Anaplastic Thyroid Cancer Cells
Giovanna Calabrese, Anna Dolcimascolo, Giuseppe Caruso & Stefano Forte
Pages: 9571-9583
Published online: 13 Nov 2019
AbstractformiR-19a Is Involved In Progression And Malignancy Of Anaplastic Thyroid Cancer Cells | Full Text | References | PDF (9.2 MB)
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Article
RETRACTED ARTICLE: Coronin3 Promotes Nasopharyngeal Carcinoma Migration And Invasion By Induction Of Epithelial-To-Mesenchymal Transition
Liyuan Fan, Yumei Wei, Xiuping Ding & Baosheng Li
Pages: 9585-9598
Published online: 13 Nov 2019
AbstractforRETRACTED ARTICLE: Coronin3 Promotes Nasopharyngeal Carcinoma Migration And Invasion By Induction Of Epithelial-To-Mesenchymal Transition | PDF (12.4 MB)
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Article
Knockdown Of Long Non-Coding RNA TP73-AS1 Inhibited Cell Proliferation And Metastasis Through Wnt/β-Catenin Pathway In Lung Adenocarcinoma
Ying Peng, Yan Xu, Guangming Yang, Shiwei Li & Zhilian Rui
Pages: 9599-9610
Published online: 13 Nov 2019
AbstractforKnockdown Of Long Non-Coding RNA TP73-AS1 Inhibited Cell Proliferation And Metastasis Through Wnt/β-Catenin Pathway In Lung Adenocarcinoma | Full Text | References | PDF (11.7 MB)
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Article
Upregulation Of miR-153 Inhibits Triple-Negative Breast Cancer Progression By Targeting ZEB2-Mediated EMT And Contributes To Better Prognosis
Dongliang Shi, Yong Li, Liqiao Fan, Qun Zhao, Bibo Tan & Guozhong Cui
Pages: 9611-9625
Published online: 13 Nov 2019
AbstractforUpregulation Of miR-153 Inhibits Triple-Negative Breast Cancer Progression By Targeting ZEB2-Mediated EMT And Contributes To Better Prognosis | Full Text | References | PDF (9.1 MB)
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Article
EZH2 Contributes To Cisplatin Resistance In Breast Cancer By Epigenetically Suppressing miR-381 Expression
Dongwei Dou, Xin Ge, Xinxing Wang, Xiaodong Xu, Zhe Zhang, Jingjing Seng, Zhang Cao, Yuanting Gu & Mingli Han
Pages: 9627-9637
Published online: 13 Nov 2019
AbstractforEZH2 Contributes To Cisplatin Resistance In Breast Cancer By Epigenetically Suppressing miR-381 Expression | Full Text | References | PDF (1.4 MB)
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Article
Silencing Of MAGI1 Promotes The Proliferation And Inhibits Apoptosis Of Glioma Cells Via The Wnt/β-Catenin And PTEN/AKT Signaling Pathways
Yongzhi Lu, Wei Sun, Liang Zhang & Junyao Li
Pages: 9639-9650
Published online: 13 Nov 2019
AbstractforSilencing Of MAGI1 Promotes The Proliferation And Inhibits Apoptosis Of Glioma Cells Via The Wnt/β-Catenin And PTEN/AKT Signaling Pathways | Full Text | References | PDF (11.8 MB)
  • 33 Views
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Article
MiR-32-5p Regulates Radiosensitization, Migration And Invasion Of Colorectal Cancer Cells By Targeting TOB1 Gene
Hong Liang, Yumei Tang, Hui Zhang & Chao Zhang
Pages: 9651-9661
Published online: 14 Nov 2019
AbstractforMiR-32-5p Regulates Radiosensitization, Migration And Invasion Of Colorectal Cancer Cells By Targeting TOB1 Gene | Full Text | References | PDF (9.2 MB)
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Case Report

Case Report
Temozolomide Combined With Capecitabine In The Treatment Of Mixed Neuroendocrine Carcinoma Of The Lung With Poor Tolerance After Repeated Radiochemotherapy: A Case Report And Literature Review
Bin Zhang, Di Wang, Xia Zhang, Xiaonan Cui, Li Kong, Minghuan Li & Jinming Yu
Pages: 9663-9668
Published online: 14 Nov 2019
AbstractforTemozolomide Combined With Capecitabine In The Treatment Of Mixed Neuroendocrine Carcinoma Of The Lung With Poor Tolerance After Repeated Radiochemotherapy: A Case Report And Literature Review | Full Text | References | PDF (2.3 MB)
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Original Research

Article
Stomatitis And Everolimus: A Review Of Current Literature On 8,201 Patients
Claudia Arena, Giuseppe Troiano, Khrystyna Zhurakivska, Riccardo Nocini & Lorenzo Lo Muzio
Pages: 9669-9683
Published online: 14 Nov 2019
AbstractforStomatitis And Everolimus: A Review Of Current Literature On 8,201 Patients | Full Text | References | PDF (632.7 KB)
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Article
Sodium Selenite Improves The Therapeutic Effect Of BMSCs Via Promoting The Proliferation And Differentiation, Thereby Promoting The Hematopoietic Factors
Dongmei Yan, Botao Tang, Lixin Yan, Lei Zhang, Meijuan Miao, Xi Chen, Guangyi Sui, Qi Zhang, Daoyuan Liu & Hui Wang
Pages: 9685-9696
Published online: 14 Nov 2019
AbstractforSodium Selenite Improves The Therapeutic Effect Of BMSCs Via Promoting The Proliferation And Differentiation, Thereby Promoting The Hematopoietic Factors | Full Text | References | PDF (5.6 MB)
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Article
IP10-CDR3 Reduces The Viability And Induces The Apoptosis Of Ovarian Cancer Cells By Down-Regulating The Expression Of Bcl-2 And Caspase 3
Qi Chen, Quan He, Lingling Zhuang, Kunya Wang, Chunhua Yin & Linsheng He
Pages: 9697-9706
Published online: 14 Nov 2019
AbstractforIP10-CDR3 Reduces The Viability And Induces The Apoptosis Of Ovarian Cancer Cells By Down-Regulating The Expression Of Bcl-2 And Caspase 3 | Full Text | References | PDF (7.6 MB)
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Article
Clinical Value Of Apatinib As A Salvage Treatment In Patients With Chemo-Refractory Advanced Cervical Cancer
Meng Su, Ya Gao, XuXue Ye, QingYu Zhou, LiHao Zhao, Xiaona Cai, Didi Chen, Huafang Su, Xiaohua Zhang & Congying Xie
Pages: 9707-9713
Published online: 14 Nov 2019
AbstractforClinical Value Of Apatinib As A Salvage Treatment In Patients With Chemo-Refractory Advanced Cervical Cancer | Full Text | References | PDF (2.2 MB)
  • 34 Views
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Article
Utility Of Plasma circBNC2 As A Diagnostic Biomarker In Epithelial Ovarian Cancer
Yingchao Hu, Yapei Zhu, Wen Zhang, Jinghe Lang & Li Ning
Pages: 9715-9723
Published online: 14 Nov 2019
AbstractforUtility Of Plasma circBNC2 As A Diagnostic Biomarker In Epithelial Ovarian Cancer | Full Text | References | PDF (2.6 MB)
  • 35 Views
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Article
Tanshinone IIA Reverses Oxaliplatin Resistance In Human Colorectal Cancer Via Inhibition Of ERK/Akt Signaling Pathway
Yonggang Zhang, Tingrui Ge, Ping Xiang, Jingyi Zhou, Shumin Tang, Haibing Mao & Qiang Tang
Pages: 9725-9734
Published online: 14 Nov 2019
AbstractforTanshinone IIA Reverses Oxaliplatin Resistance In Human Colorectal Cancer Via Inhibition Of ERK/Akt Signaling Pathway | Full Text | References | PDF (7.8 MB)
  • 30 Views
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Article
A Retrospective Case Series Of High-Intensity Focused Ultrasound (HIFU) In Combination With Gemcitabine And Oxaliplatin (Gemox) On Treating Elderly Middle And Advanced Pancreatic Cancer
Shuang-fen Tao, Wen-hua Gu, Jian-chun Gu, Mei-ling Zhu, Qing Wang & Lei-zhen Zheng
Pages: 9735-9745
Published online: 15 Nov 2019
AbstractforA Retrospective Case Series Of High-Intensity Focused Ultrasound (HIFU) In Combination With Gemcitabine And Oxaliplatin (Gemox) On Treating Elderly Middle And Advanced Pancreatic Cancer | Full Text | References | PDF (1.5 MB)
  • 53 Views
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Article
The Biological-Behavioral Effect Of Neuritin On Non-Small Cell Lung Cancer Vascular Endothelial Cells Via VEGFR And Notch1
Qiao Zhang, Juan Zhang, Jian Zhang, Patiguli Aerxiding, Amina Quhai, Cuncun Chen & Li Shan
Pages: 9747-9755
Published online: 20 Nov 2019
AbstractforThe Biological-Behavioral Effect Of Neuritin On Non-Small Cell Lung Cancer Vascular Endothelial Cells Via VEGFR And Notch1 | Full Text | References | PDF (5 MB)
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Article
Immune-Mediated Antitumor Effect By VEGFR2 Selective Inhibitor For Gastric Cancer
Ju Yang, Jing Yan, Jie Shao, Qiuping Xu, Fanyan Meng, Fangjun Chen, Naiqing Ding, Shiyao Du, Shujuan Zhou, Juan Cai, Qin Wang & Baorui Liu
Pages: 9757-9765
Published online: 15 Nov 2019
AbstractforImmune-Mediated Antitumor Effect By VEGFR2 Selective Inhibitor For Gastric Cancer | Full Text | References | PDF (5 MB)
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Article
Oncogenic Activities Of UBE2S Mediated By VHL/HIF-1α/STAT3 Signal Via The Ubiquitin-Proteasome System In PDAC
Lei Wang, Yiyi Liang, Pengping Li, Qingchun Liang, Haijun Sun, Dazhou Xu & Wei Hu
Pages: 9767-9781
Published online: 15 Nov 2019
AbstractforOncogenic Activities Of UBE2S Mediated By VHL/HIF-1α/STAT3 Signal Via The Ubiquitin-Proteasome System In PDAC | Full Text | References | PDF (8.7 MB)
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Article
Inhibition Of Glycogen Synthase Kinase 3 Beta Suppresses The Growth And Survival Of Skull Base Chordoma Cells By Downregulating Brachyury Expression
Xudong Yan, Zhiyuan Li, Hong Li, Pei Liu, Zehang Zhao, Shan Cheng, Zhenlin Wang & Qiuhang Zhang
Pages: 9783-9791
Published online: 18 Nov 2019
AbstractforInhibition Of Glycogen Synthase Kinase 3 Beta Suppresses The Growth And Survival Of Skull Base Chordoma Cells By Downregulating Brachyury Expression | Full Text | References | PDF (2.9 MB)
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Corrigendum

Correction
Akt/mTOR-Mediated Autophagy Confers Resistance To BET Inhibitor JQ1 In Ovarian Cancer [Corrigendum]
Page: 9793
Published online: 15 Nov 2019
CitationforAkt/mTOR-Mediated Autophagy Confers Resistance To BET Inhibitor JQ1 In Ovarian Cancer [Corrigendum] | Full Text | PDF (1.4 MB)
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Original Research

Article
RETRACTED ARTICLE: MicroRNA-618 Directly Targets Metadherin mRNA To Suppress The Malignant Phenotype Of Osteosarcoma Cells By Reducing PTEN-AKT Pathway Output
Bohan Li, Jie Zhao, Qian Zhao, Dongjin Wu, Cheng Zhang, Kun Zhao, Yang Song & Chunzheng Gao
Pages: 9795-9807
Published online: 15 Nov 2019
AbstractforRETRACTED ARTICLE: MicroRNA-618 Directly Targets Metadherin mRNA To Suppress The Malignant Phenotype Of Osteosarcoma Cells By Reducing PTEN-AKT Pathway Output | PDF (11.7 MB)
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Article
FGFR1 Induces Acquired Resistance Against Gefitinib By Activating AKT/mTOR Pathway In NSCLC
Dan Zhang, Li-li Han, Fen Du, Xiao-meng Liu, Jin Li, Hui-hui Wang, Ming-hui Song, Zeng Li & Guo-yin Li
Pages: 9809-9816
Published online: 18 Nov 2019
AbstractforFGFR1 Induces Acquired Resistance Against Gefitinib By Activating AKT/mTOR Pathway In NSCLC | Full Text | References | PDF (3.5 MB)
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Review

Review Article
The Exosome And Breast Cancer Cell Plasticity
Xiaoyun Mao & Feng Jin
Pages: 9817-9825
Published online: 18 Nov 2019
AbstractforThe Exosome And Breast Cancer Cell Plasticity | Full Text | References | PDF (430.7 KB)
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Original Research

Article
MIR22HG As A Tumor Suppressive lncRNA In HCC: A Comprehensive Analysis Integrating RT-qPCR, mRNA-Seq, And Microarrays
Li Gao, Dan-dan Xiong, Rong-quan He, Xia Yang, Ze-feng Lai, Li-min Liu, Zhi-guang Huang, Hua-yu Wu, Li-hua Yang, Jie Ma, Sheng-hua Li, Peng Lin, Hong Yang, Dian-zhong Luo, Yi-wu Dang & Gang Chen
Pages: 9827-9848
Published online: 18 Nov 2019
AbstractforMIR22HG As A Tumor Suppressive lncRNA In HCC: A Comprehensive Analysis Integrating RT-qPCR, mRNA-Seq, And Microarrays | Full Text | References | PDF (19 MB)
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Article
THUMPD3-AS1 Is Correlated With Non-Small Cell Lung Cancer And Regulates Self-Renewal Through miR-543 And ONECUT2
Jia Hu, Youfang Chen, Xiaodong Li, Huikai Miao, Rongzhen Li, Dongni Chen & Zhesheng Wen
Pages: 9849-9860
Published online: 19 Nov 2019
AbstractforTHUMPD3-AS1 Is Correlated With Non-Small Cell Lung Cancer And Regulates Self-Renewal Through miR-543 And ONECUT2 | Full Text | References | PDF (8.7 MB)
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Article
TNIP1 Inhibits Proliferation And Promotes Apoptosis In Clear Cell Renal Carcinoma Through Targeting C/Ebpβ
Yong Yang, Jinhai Fan, Shenglu Han & Enyuan Li
Pages: 9861-9871
Published online: 18 Nov 2019
AbstractforTNIP1 Inhibits Proliferation And Promotes Apoptosis In Clear Cell Renal Carcinoma Through Targeting C/Ebpβ | Full Text | References | PDF (3.7 MB)
  • 35 Views
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Article
Long Noncoding RNA TP73-AS1 Modulates Medulloblastoma Progression In Vitro And In Vivo By Sponging miR-494-3p And Targeting EIF5A2
Bing Li, Mingfeng Shen, Hongwei Yao, Xuan Chen & Zhiqiang Xiao
Pages: 9873-9885
Published online: 18 Nov 2019
AbstractforLong Noncoding RNA TP73-AS1 Modulates Medulloblastoma Progression In Vitro And In Vivo By Sponging miR-494-3p And Targeting EIF5A2 | Full Text | References | PDF (9.8 MB)
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Article
RETRACTED ARTICLE: LncRNA NEAT1 Promotes Proliferation, Migration And Invasion Via Regulating miR-296-5p/CNN2 Axis In Hepatocellular Carcinoma Cells
Yandong Li, Xiyan Ding, Shuqiu Xiu, Guobin Du & Yahui Liu
Pages: 9887-9897
Published online: 18 Nov 2019
AbstractforRETRACTED ARTICLE: LncRNA NEAT1 Promotes Proliferation, Migration And Invasion Via Regulating miR-296-5p/CNN2 Axis In Hepatocellular Carcinoma Cells | PDF (7.3 MB)
  • 10 Views
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Article
PDHA1 Gene Knockout In Human Esophageal Squamous Cancer Cells Resulted In Greater Warburg Effect And Aggressive Features In Vitro And In Vivo
Lan Liu, Jing Cao, Jing Zhao, Xiangyu Li, Zhenhe Suo & Huixiang Li
Pages: 9899-9913
Published online: 18 Nov 2019
AbstractforPDHA1 Gene Knockout In Human Esophageal Squamous Cancer Cells Resulted In Greater Warburg Effect And Aggressive Features In Vitro And In Vivo | Full Text | References | PDF (10.2 MB)
  • 164 Views
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Article
Hypermethylated KLF9 Is An Independent Prognostic Factor For Favorable Outcome In Breast Cancer
Lei Wang, Qiqi Mao, Shaocheng Zhou & Xiaochun Ji
Pages: 9915-9926
Published online: 18 Nov 2019
AbstractforHypermethylated KLF9 Is An Independent Prognostic Factor For Favorable Outcome In Breast Cancer | Full Text | References | PDF (6.4 MB)
  • 28 Views
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Article
RRM2 Regulated By LINC00667/miR-143-3p Signal Is Responsible For Non-Small Cell Lung Cancer Cell Progression
Yanbing Yang, Sensen Li, Juan Cao, Yaojun Li, Haiying Hu & Zhuyu Wu
Pages: 9927-9939
Published online: 20 Nov 2019
AbstractforRRM2 Regulated By LINC00667/miR-143-3p Signal Is Responsible For Non-Small Cell Lung Cancer Cell Progression | Full Text | References | PDF (8.4 MB)
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Case Series

Case Report
Unleashing The Potential Of Multiple-Targeted Therapies In Hepatobiliary Cancers: Two Cases, Cocktail Therapy With Nine Molecular Targeted Agents And Long-Lasting Survival
Jianzhen Lin, Xiaobo Yang, Yuan Xie & Haitao Zhao
Pages: 9941-9945
Published online: 19 Nov 2019
AbstractforUnleashing The Potential Of Multiple-Targeted Therapies In Hepatobiliary Cancers: Two Cases, Cocktail Therapy With Nine Molecular Targeted Agents And Long-Lasting Survival | Full Text | References | PDF (2.4 MB)
  • 23 Views
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Original Research

Article
Fibrinogen Is A Coagulation Marker Associated With The Prognosis Of Endometrial Cancer
Qing Li, Rong Cong, Fanfei Kong, Jian Ma, Qijun Wu & Xiaoxin Ma
Pages: 9947-9956
Published online: 19 Nov 2019
AbstractforFibrinogen Is A Coagulation Marker Associated With The Prognosis Of Endometrial Cancer | Full Text | References | PDF (460.5 KB)
  • 73 Views
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Article
circ-MYBL2 Serves As A Sponge For miR-361-3p Promoting Cervical Cancer Cells Proliferation And Invasion
Jinrong Wang, Hui Li & Zhen Liang
Pages: 9957-9964
Published online: 20 Nov 2019
Abstractforcirc-MYBL2 Serves As A Sponge For miR-361-3p Promoting Cervical Cancer Cells Proliferation And Invasion | Full Text | References | PDF (5 MB)
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Case Report

Case Report
Pancytopenia And Limbic Encephalopathy Complicating Immunotherapy For Clear Cell Endometrial Cancer With Microsatellite Instability-High (MSI-H)
Aladdin Kanbour, Kakil Ibrahim Rasul, Salha Bujassoum Albader, Reem Jawad Al Sulaiman, Gayan Melikyan, Hanan Farghaly, Zsolt Lengyel, Yousef Al Rimawi, Dina Soliman & Nabil Elhadi Omar
Pages: 9965-9973
Published online: 19 Nov 2019
AbstractforPancytopenia And Limbic Encephalopathy Complicating Immunotherapy For Clear Cell Endometrial Cancer With Microsatellite Instability-High (MSI-H) | Full Text | References | PDF (3.2 MB)
  • 74 Views
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Original Research

Article
miR-124 Functions As A Melanoma Tumor Suppressor By Targeting RACK1
Congcong Shen, Hui Hua, Lixiong Gu, Shuanglin Cao, Hengji Cai, Xiaodong Yao & Xiaodong Chen
Pages: 9975-9986
Published online: 19 Nov 2019
AbstractformiR-124 Functions As A Melanoma Tumor Suppressor By Targeting RACK1 | Full Text | References | PDF (6.4 MB)
  • 78 Views
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Article
Upregulation Of miR-149-3p Suppresses Spinal Chordoma Malignancy By Targeting Smad3
Jie Yao & Xuejian Wu
Pages: 9987-9997
Published online: 19 Nov 2019
AbstractforUpregulation Of miR-149-3p Suppresses Spinal Chordoma Malignancy By Targeting Smad3 | Full Text | References | PDF (7.9 MB)
  • 82 Views
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Article
Mutations In Thirty Hotspot Genes In Newly Diagnosed Chinese Multiple Myeloma Patients
Ying Hu, Wenming Chen & Jingbo Wang
Pages: 9999-10010
Published online: 21 Nov 2019
AbstractforMutations In Thirty Hotspot Genes In Newly Diagnosed Chinese Multiple Myeloma Patients | Full Text | References | PDF (11.3 MB)
  • 25 Views
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Article
Upregulated LINC00565 Accelerates Ovarian Cancer Progression By Targeting GAS6
Mi Gong, Chengyan Luo, Huangyang Meng, Siyue Li, Sipei Nie, Yi Jiang, Yicong Wan, Huijian Li & Wenjun Cheng
Pages: 10011-10022
Published online: 20 Nov 2019
AbstractforUpregulated LINC00565 Accelerates Ovarian Cancer Progression By Targeting GAS6 | Full Text | References | PDF (6 MB)
  • 27 Views
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Article
Metabonomic Variation of Exopolysaccharide from Rhizopus nigricans on AOM/DSS-Induced Colorectal Cancer in Mice
Yan Lu, Jiayue Wang, Yueshan Ji & Kaoshan Chen
Pages: 10023-10033
Published online: 20 Nov 2019
AbstractforMetabonomic Variation of Exopolysaccharide from Rhizopus nigricans on AOM/DSS-Induced Colorectal Cancer in Mice | Full Text | References | PDF (11.2 MB)
  • 46 Views
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Article
Serum Exosomal Long Noncoding RNA pcsk2-2:1 As A Potential Novel Diagnostic Biomarker For Gastric Cancer
Chenchen Cai, Haoliang Zhang, Yingxing Zhu, Peiming Zheng, Yinhai Xu, Jingfang Sun, Miaomiao Zhang, Ting Lan, Bing Gu, Shibao Li & Ping Ma
Pages: 10035-10041
Published online: 25 Nov 2019
AbstractforSerum Exosomal Long Noncoding RNA pcsk2-2:1 As A Potential Novel Diagnostic Biomarker For Gastric Cancer | Full Text | References | PDF (8.3 MB)
  • 57 Views
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Article
Prevalence of DLL3, CTLA-4 and MSTN Expression in Patients with Small Cell Lung Cancer
Orgilmaa Regzedmaa, Ying Li, Yongwen Li, Hongbing Zhang, Jin Wang, Hao Gong, Yin Yuan, Weiting Li, Hongyu Liu & Jun Chen
Pages: 10043-10055
Published online: 21 Nov 2019
AbstractforPrevalence of DLL3, CTLA-4 and MSTN Expression in Patients with Small Cell Lung Cancer | Full Text | References | PDF (1.5 MB)
  • 59 Views
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Article
Integrated Analysis To Identify Molecular Biomarkers Of High-Grade Serous Ovarian Cancer
Manfei Si, Junji Zhang, Jianzhong Cao, Zhibo Xie, Shan Shu, Yapei Zhu & Jinghe Lang
Pages: 10057-10075
Published online: 21 Nov 2019
AbstractforIntegrated Analysis To Identify Molecular Biomarkers Of High-Grade Serous Ovarian Cancer | Full Text | References | PDF (12.3 MB)
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Article
Pretreatment Aspartate Aminotransferase-to-Alanine Aminotransferase (De Ritis) Ratio Predicts the Prognosis of Nonmetastatic Nasopharyngeal Carcinoma
Jiayuan Wu, Shasha Li, Yufeng Wang & Liren Hu
Pages: 10077-10087
Published online: 22 Nov 2019
AbstractforPretreatment Aspartate Aminotransferase-to-Alanine Aminotransferase (De Ritis) Ratio Predicts the Prognosis of Nonmetastatic Nasopharyngeal Carcinoma | Full Text | References | PDF (817 KB)
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Article
miR-193b Increases the Chemosensitivity of Osteosarcoma Cells by Promoting FEN1-Mediated Autophagy
Suwei Dong, Yanbin Xiao, Xiang Ma, Wei He, Jianping Kang, Zhuohui Peng, Lei Wang & Zhen Li
Pages: 10089-10098
Published online: 22 Nov 2019
AbstractformiR-193b Increases the Chemosensitivity of Osteosarcoma Cells by Promoting FEN1-Mediated Autophagy | Full Text | References | PDF (5.5 MB)
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Article
PD-L1 Expression Is Regulated By NF-κB During EMT Signaling In Gastric Carcinoma
Dan Xu, Jing Li, Rui-Yang Li, Ting Lan, Chi Xiao & Ping Gong
Pages: 10099-10105
Published online: 25 Nov 2019
AbstractforPD-L1 Expression Is Regulated By NF-κB During EMT Signaling In Gastric Carcinoma | Full Text | References | PDF (3.8 MB)
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Article
LncRNA RGMB-AS1 Promotes Glioma Growth and Invasion Through miR-1200/HOXB2 Axis
Bailin Pan, Ming Zhao, Ning Wang, Longbiao Xu, Tianya Wu & Zequn Li
Pages: 10107-10114
Published online: 25 Nov 2019
AbstractforLncRNA RGMB-AS1 Promotes Glioma Growth and Invasion Through miR-1200/HOXB2 Axis | Full Text | References | PDF (8.5 MB)
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Article
Interaction Of c-Jun And HOTAIR- Increased Expression Of p21 Converge In Polyphyllin I-Inhibited Growth Of Human Lung Cancer Cells
YueYang Zhao, XiaoJuan Tang, Yuhua Huang, Qing Tang, ChangJu Ma, Fang Zheng, WanYin Wu & Swei Sunny Hann
Pages: 10115-10127
Published online: 25 Nov 2019
AbstractforInteraction Of c-Jun And HOTAIR- Increased Expression Of p21 Converge In Polyphyllin I-Inhibited Growth Of Human Lung Cancer Cells | Full Text | References | PDF (7.2 MB)
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Article
RETRACTED ARTICLE: Propofol Suppresses Proliferation, Migration, Invasion And Promotes Apoptosis By Upregulating microRNA-140-5p In Gastric Cancer Cells
Fengbo Zhu, Qiuxia Li, Ying Yang, Liangui Wang & Jing Wang
Pages: 10129-10138
Published online: 25 Nov 2019
AbstractforRETRACTED ARTICLE: Propofol Suppresses Proliferation, Migration, Invasion And Promotes Apoptosis By Upregulating microRNA-140-5p In Gastric Cancer Cells | PDF (6 MB)
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Article
Induction Of XLF And 53BP1 Expression Is Associated With Temozolomide Resistance In Glioblastoma Cells
Tongxia Zhang, Jie Chai & Lingyi Chi
Pages: 10139-10151
Published online: 25 Nov 2019
AbstractforInduction Of XLF And 53BP1 Expression Is Associated With Temozolomide Resistance In Glioblastoma Cells | Full Text | References | PDF (12.4 MB)
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Article
Downregulation of the Helicase Lymphoid-Specific (HELLS) Gene Impairs Cell Proliferation and Induces Cell Cycle Arrest in Colorectal Cancer Cells
Xi Liu, Xuyang Hou, Yan Zhou, Qinglong Li, Fanhua Kong, Shichao Yan, Sanlin Lei, Li Xiong & Jun He
Pages: 10153-10163
Published online: 26 Nov 2019
AbstractforDownregulation of the Helicase Lymphoid-Specific (HELLS) Gene Impairs Cell Proliferation and Induces Cell Cycle Arrest in Colorectal Cancer Cells | Full Text | References | PDF (6.8 MB)
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Article
Prevalence And Clinical Significance Of Oncogenic CD79B And MYD88 Mutations In Primary Testicular Diffuse Large B-Cell Lymphoma: A Retrospective Study In China
Yan-ping Chen, Long-feng Ke, Jian-ping Lu, Jian-chao Wang, Wei-feng Zhu, Fang-fang Chen, Shao-feng Lin, Chun-wei Xu, Mei-juan Wu & Gang Chen
Pages: 10165-10175
Published online: 26 Nov 2019
AbstractforPrevalence And Clinical Significance Of Oncogenic CD79B And MYD88 Mutations In Primary Testicular Diffuse Large B-Cell Lymphoma: A Retrospective Study In China | Full Text | References | PDF (4.6 MB)
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Article
Osteopontin Mediates Cetuximab Resistance via the MAPK Pathway in NSCLC Cells
Jian Cui, Jun Wang, Chao Lin, Jixiang Liu & Wei Zuo
Pages: 10177-10185
Published online: 26 Nov 2019
AbstractforOsteopontin Mediates Cetuximab Resistance via the MAPK Pathway in NSCLC Cells | Full Text | References | PDF (3.6 MB)
  • 31 Views
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Article
The Therapeutic Effect of Melatonin on GC by Inducing Cell Apoptosis and Autophagy Induced by Endoplasmic Reticulum Stress
Yanshan Zheng, Jiawei Tu, Xinxin Wang, Yue Yu, Jiajia Li, Yin Jin & Jiansheng Wu
Pages: 10187-10198
Published online: 26 Nov 2019
AbstractforThe Therapeutic Effect of Melatonin on GC by Inducing Cell Apoptosis and Autophagy Induced by Endoplasmic Reticulum Stress | Full Text | References | PDF (9.5 MB)
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Article
Identification Of Novel lncRNAs For Detection Of HBV-Associated Hepatocellular Carcinoma
Yuwei Li, Xia Chen, Hengliu Huang, Guangyao Li, Ling Liao, Tao Yuan & Shaoli Deng
Pages: 10199-10211
Published online: 27 Nov 2019
AbstractforIdentification Of Novel lncRNAs For Detection Of HBV-Associated Hepatocellular Carcinoma | Full Text | References | PDF (8.3 MB)
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Article
P120-Catenin And Its Phosphorylation On Tyr228 Inhibits Proliferation And Invasion In Colon Adenocarcinoma Cells
Xiuming Ding, Xiuqin Wang, Shifen Lu, Xuemei Gao & Shumei Ju
Pages: 10213-10225
Published online: 26 Nov 2019
AbstractforP120-Catenin And Its Phosphorylation On Tyr228 Inhibits Proliferation And Invasion In Colon Adenocarcinoma Cells | Full Text | References | PDF (8.3 MB)
  • 24 Views
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Article
RETARCTED ARTICLE: Resveratrol Reverses Cigarette Smoke-Induced Urocystic Epithelial–Mesenchymal Transition via Suppression of STAT3 Phosphorylation in SV-HUC-1-Immortalized Human Urothelial Cells
Hongliang Sun, Zhiqiang Zhang, Taotao Zhang, Hao Geng, Dongdong Xie, Yi Wang, Demao Ding, Tao Zhang & Dexin Yu
Pages: 10227-10237
Published online: 26 Nov 2019
AbstractforRETARCTED ARTICLE: Resveratrol Reverses Cigarette Smoke-Induced Urocystic Epithelial–Mesenchymal Transition via Suppression of STAT3 Phosphorylation in SV-HUC-1-Immortalized Human Urothelial Cells | PDF (7.1 MB)
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Article
Inhibition of ISG15 Enhances the Anti-Cancer Effect of Trametinib in Colon Cancer Cells
Sheng Zhou, Meilin Ren, Huanji Xu, Hongwei Xia, Qiulin Tang & Ming Liu
Pages: 10239-10250
Published online: 26 Nov 2019
AbstractforInhibition of ISG15 Enhances the Anti-Cancer Effect of Trametinib in Colon Cancer Cells | Full Text | References | PDF (7.8 MB)
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Article
RETRACTED ARTICLE: MicroRNA-188-5p Promotes Epithelial–Mesenchymal Transition by Targeting ID4 Through Wnt/β‑catenin Signaling in Retinoblastoma
Ming Yang, Yang Li & Wenbin Wei
Pages: 10251-10262
Published online: 27 Nov 2019
AbstractforRETRACTED ARTICLE: MicroRNA-188-5p Promotes Epithelial–Mesenchymal Transition by Targeting ID4 Through Wnt/β‑catenin Signaling in Retinoblastoma | PDF (10.2 MB)
  • 16 Views
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Article
Siglecs, Novel Immunotherapy Targets, Potentially Enhance The Effectiveness of Existing Immune Checkpoint Inhibitors in Glioma Immunotherapy
Guan-Zhang Li, Ke-Nan Zhang, Zheng Wang, Hui-Min Hu, Zhi-Liang Wang, Ruo-Yu Huang, Hao-Yu Jiang, You Zhai, Yue-Mei Feng, Yuan-Hao Chang, Ren-Peng Li, Fan Wu, Fan Zeng, Tao Jiang & Wei Zhang
Pages: 10263-10273
Published online: 27 Nov 2019
AbstractforSiglecs, Novel Immunotherapy Targets, Potentially Enhance The Effectiveness of Existing Immune Checkpoint Inhibitors in Glioma Immunotherapy | Full Text | References | PDF (12 MB)
  • 36 Views
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Article
miR-140-3p Suppresses Cell Growth And Induces Apoptosis In Colorectal Cancer By Targeting PD-L1
Wei Jiang, Tao Li, Jingjing Wang, Ruonan Jiao, Xiao Shi, Xiaodan Huang & Guozhong Ji
Pages: 10275-10285
Published online: 27 Nov 2019
AbstractformiR-140-3p Suppresses Cell Growth And Induces Apoptosis In Colorectal Cancer By Targeting PD-L1 | Full Text | References | PDF (7 MB)
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Article
The Long Non-Coding RNA-14327.1 Promotes Migration and Invasion Potential of Endometrial Carcinoma Cells by Stabilizing the Potassium Channel Kca3.1
Yingli Zhang, Ping Zhang, Lu Chen, Lingqin Zhao, Jianqing Zhu & Tao Zhu
Pages: 10287-10297
Published online: 27 Nov 2019
AbstractforThe Long Non-Coding RNA-14327.1 Promotes Migration and Invasion Potential of Endometrial Carcinoma Cells by Stabilizing the Potassium Channel Kca3.1 | Full Text | References | PDF (6.7 MB)
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Article
Aberrantly High Expression Of NOK/STYK1 Is Tightly Associated With The Activation Of The AKT/GSK3β/N-Cadherin Pathway In Non-Small Cell Lung Cancer
Zhao Huang, Nan Ma, Yan-Lu Xiong, Lei Wang, Wei-Miao Li, Yuan-Yang Lai, Chen-Xi Zhang, Zhi-Pei Zhang, Xiao-Fei Li & Jin-Bo Zhao
Pages: 10299-10309
Published online: 27 Nov 2019
AbstractforAberrantly High Expression Of NOK/STYK1 Is Tightly Associated With The Activation Of The AKT/GSK3β/N-Cadherin Pathway In Non-Small Cell Lung Cancer | Full Text | References | PDF (8.3 MB)
  • 25 Views
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Article
Influence and mechanism of miR-99a suppressing development of colorectal cancer (CRC) with diabetes mellitus (DM)
Peixuan Zhu, Jiahao Liu, Meijuan Lu, Gongfa Wu, Xutao Lin, Longmei Cai & Xiaona Zhang
Pages: 10311-10321
Published online: 27 Nov 2019
AbstractforInfluence and mechanism of miR-99a suppressing development of colorectal cancer (CRC) with diabetes mellitus (DM) | Full Text | References | PDF (2.1 MB)
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Article
Long Non-Coding RNA HOTAIR Modulates KLF12 to Regulate Gastric Cancer Progression via PI3K/ATK Signaling Pathway by Sponging miR-618
Jin Xun, Chunfeng Wang, Jianning Yao, Bing Gao & Lianfeng Zhang
Pages: 10323-10334
Published online: 27 Nov 2019
AbstractforLong Non-Coding RNA HOTAIR Modulates KLF12 to Regulate Gastric Cancer Progression via PI3K/ATK Signaling Pathway by Sponging miR-618 | Full Text | References | PDF (8.5 MB)
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Review

Review Article
Evaluating the Safety and Efficacy of Nivolumab in Patients with Advanced Hepatocellular Carcinoma: Evidence to Date
Sri Harsha Tella, Amit Mahipal, Anuhya Kommalapati & Zhaohui Jin
Pages: 10335-10342
Published online: 28 Nov 2019
AbstractforEvaluating the Safety and Efficacy of Nivolumab in Patients with Advanced Hepatocellular Carcinoma: Evidence to Date | Full Text | References | PDF (377.7 KB)
  • 33 Views
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Review Article
Recent Progress in Rare Oncogenic Drivers and Targeted Therapy For Non-Small Cell Lung Cancer
Yijia Guo, Rui Cao, Xiangyan Zhang, Letian Huang, Li Sun, Jianzhu Zhao, Jietao Ma & Chengbo Han
Pages: 10343-10360
Published online: 28 Nov 2019
AbstractforRecent Progress in Rare Oncogenic Drivers and Targeted Therapy For Non-Small Cell Lung Cancer | Full Text | References | PDF (1.5 MB)
  • 62 Views
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Original Research

Article
Weighted Gene Co-Expression Network Analysis Identified Cancer Cell Proliferation as a Common Phenomenon During Perineural Invasion
Ting Huang, Yiwei Wang, Zhihua Wang, Yunxia Cui, Xiao Sun & Yudong Wang
Pages: 10361-10374
Published online: 28 Nov 2019
AbstractforWeighted Gene Co-Expression Network Analysis Identified Cancer Cell Proliferation as a Common Phenomenon During Perineural Invasion | Full Text | References | PDF (12.8 MB)
  • 39 Views
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Article
Long Non-Coding RNA TUG1 Modulates Proliferation, Migration, And Invasion Of Acute Myeloid Leukemia Cells Via Regulating miR-370-3p/MAPK1/ERK
Gang Li, Peiming Zheng, Huiling Wang, Yushu Ai & Xiaohuan Mao
Pages: 10375-10388
Published online: 29 Nov 2019
AbstractforLong Non-Coding RNA TUG1 Modulates Proliferation, Migration, And Invasion Of Acute Myeloid Leukemia Cells Via Regulating miR-370-3p/MAPK1/ERK | Full Text | References | PDF (12.2 MB)
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Article
Comparative Effectiveness of Radiofrequency Ablation, Surgical Resection and Transplantation for Early Hepatocellular Carcinoma by Cancer Risk Groups: Results of Propensity Score-Weighted Analysis
Wei-Jia Zhao, Gui-Qi Zhu, Yi-Ming Wu, Wen-Wen Wang & Bing-Long Bai
Pages: 10389-10400
Published online: 29 Nov 2019
AbstractforComparative Effectiveness of Radiofrequency Ablation, Surgical Resection and Transplantation for Early Hepatocellular Carcinoma by Cancer Risk Groups: Results of Propensity Score-Weighted Analysis | Full Text | References | PDF (3.1 MB)
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Article
Long Non-Coding RNA NEAT1 Promoted Hepatocellular Carcinoma Cell Proliferation and Reduced Apoptosis Through the Regulation of Let-7b-IGF-1R Axis
Qin Liu, Hexian Shi, Jianbo Yang & Ning Jiang
Pages: 10401-10413
Published online: 29 Nov 2019
AbstractforLong Non-Coding RNA NEAT1 Promoted Hepatocellular Carcinoma Cell Proliferation and Reduced Apoptosis Through the Regulation of Let-7b-IGF-1R Axis | Full Text | References | PDF (13.1 MB)
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Article
Recombinant Viral Capsid Protein L2 (rVL2) of HPV 16 Suppresses Cell Proliferation and Glucose Metabolism via ITGB7/C/EBPβ Signaling Pathway in Cervical Cancer Cell Lines
Zhihong Chai, Yufei Yang, ZhongYi Gu, Xianli Cai, Wenwei Ye, Lin Kong, Xiaoxiao Qiu, Lingxiao Ying, Ziliang Wang & Linyou Wang
Pages: 10415-10425
Published online: 29 Nov 2019
AbstractforRecombinant Viral Capsid Protein L2 (rVL2) of HPV 16 Suppresses Cell Proliferation and Glucose Metabolism via ITGB7/C/EBPβ Signaling Pathway in Cervical Cancer Cell Lines | Full Text | References | PDF (9 MB)
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Article
Overexpressing CCT6A Contributes To Cancer Cell Growth By Affecting The G1-To-S Phase Transition And Predicts A Negative Prognosis In Hepatocellular Carcinoma
Guofen Zeng, Jialiang Wang, Yanlin Huang, Yifan Lian, Dongmei Chen, Huan Wei, Chaoshuang Lin & Yuehua Huang
Pages: 10427-10439
Published online: 29 Nov 2019
AbstractforOverexpressing CCT6A Contributes To Cancer Cell Growth By Affecting The G1-To-S Phase Transition And Predicts A Negative Prognosis In Hepatocellular Carcinoma | Full Text | References | PDF (8.3 MB)
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Article
miR-424-5p Promotes Proliferation, Migration and Invasion of Laryngeal Squamous Cell Carcinoma
Yujun Li, Jie Liu, Wanglai Hu, Yuliang Zhang, Jiangwei Sang, Huizheng Li, Teng Ma, Yunfeng Bo, Tao Bai, Huina Guo, Yan Lu, Xuting Xue, Min Niu, Shanshan Ge, Shuxin Wen, Binquan Wang, Wei Gao & Yongyan Wu
Pages: 10441-10453
Published online: 29 Nov 2019
AbstractformiR-424-5p Promotes Proliferation, Migration and Invasion of Laryngeal Squamous Cell Carcinoma | Full Text | References | PDF (8.8 MB)
  • 34 Views
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Article
Inhibition of KPNB1 Inhibits Proliferation and Promotes Apoptosis of Chronic Myeloid Leukemia Cells Through Regulation of E2F1
Teng Wang, Zhenglan Huang, Ningshu Huang, Yuhang Peng, Miao Gao, Xin Wang & Wenli Feng
Pages: 10455-10467
Published online: 02 Dec 2019
AbstractforInhibition of KPNB1 Inhibits Proliferation and Promotes Apoptosis of Chronic Myeloid Leukemia Cells Through Regulation of E2F1 | Full Text | References | PDF (10.6 MB)
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Article
Prognostic Significance of LDH Ratio in Serum/Cerebral Spinal Fluid of Patients with Primary Testicular Diffuse Large B-Cell Lymphoma
Yi-Zhen Liu, Pan Luo, Cheng Liu, Kai Xue, Jia Jin, Zu-Guang Xia, Xiao-Jian Liu, Qun-Ling Zhang, Jun-Ning Cao, Xiao-Nan Hong & Fang-Fang Lv
Pages: 10469-10475
Published online: 02 Dec 2019
AbstractforPrognostic Significance of LDH Ratio in Serum/Cerebral Spinal Fluid of Patients with Primary Testicular Diffuse Large B-Cell Lymphoma | Full Text | References | PDF (2.6 MB)
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Article
Differential Expression And Effects Of Peroxiredoxin-6 On Drug Resistance And Cancer Stem Cell-Like Properties In Non-Small Cell Lung Cancer
Jun Xu, Qiang Su, Mingxia Gao, Qingsong Liang, Junfeng Li & Xu Chen
Pages: 10477-10486
Published online: 02 Dec 2019
AbstractforDifferential Expression And Effects Of Peroxiredoxin-6 On Drug Resistance And Cancer Stem Cell-Like Properties In Non-Small Cell Lung Cancer | Full Text | References | PDF (6.5 MB)
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Article
Further Study of Circulating Antibodies to P16, CD25 and FOXP3 in Hepatocellular Carcinoma
Jiaxin Wang, Yangchun Xu, Yanjun Wang, Xuan Zhang & Guizhen Zhang
Pages: 10487-10493
Published online: 02 Dec 2019
AbstractforFurther Study of Circulating Antibodies to P16, CD25 and FOXP3 in Hepatocellular Carcinoma | Full Text | References | PDF (647.4 KB)
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Case Report

Case Report
Initial Therapy of Advanced Anaplastic Thyroid Cancer via Targeting VEGFR-2: A Case Report
Lin Cheng, Qiong Jiao, Yuchen Jin, Hao Fu, Huizhen Zhang & Libo Chen
Pages: 10495-10500
Published online: 02 Dec 2019
AbstractforInitial Therapy of Advanced Anaplastic Thyroid Cancer via Targeting VEGFR-2: A Case Report | Full Text | References | PDF (4.3 MB)
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Original Research

Article
JAZF1 Suppresses Papillary Thyroid Carcinoma Cell Proliferation and Facilitates Apoptosis via Regulating TAK1/NF-κB Pathways
Liangliang Huang, Yuhuai Cai, Yi Luo, Daigang Xiong, Zeyu Hou, Junyuan Lv, Feng Zeng, Yan Yang & Xiaoming Cheng
Pages: 10501-10514
Published online: 02 Dec 2019
AbstractforJAZF1 Suppresses Papillary Thyroid Carcinoma Cell Proliferation and Facilitates Apoptosis via Regulating TAK1/NF-κB Pathways | Full Text | References | PDF (10.2 MB)
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Article
miR-509-5p Downregulation Is Associated With Male Infertility And Acts As A Suppressor In Testicular Germ Cell Tumor Cells Through Targeting MDM2
Jinxia Sun, Lei Niu, Shanxia Gao, Xijuan Yi & Jianxia Chen
Pages: 10515-10522
Published online: 02 Dec 2019
AbstractformiR-509-5p Downregulation Is Associated With Male Infertility And Acts As A Suppressor In Testicular Germ Cell Tumor Cells Through Targeting MDM2 | Full Text | References | PDF (5.1 MB)
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Article
EPS8 is a Potential Oncogene in Glioblastoma
Gang Yang, Yong-bin Lu & Quan-lin Guan
Pages: 10523-10534
Published online: 02 Dec 2019
AbstractforEPS8 is a Potential Oncogene in Glioblastoma | Full Text | References | PDF (8.9 MB)
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Article
MicroRNA-497-5p Induces Cell Cycle Arrest Of Cervical Cancer Cells In S Phase By Targeting CBX4
Yani Chen, Juan Du, Yu Wang, Haiyan Shi, Qiuyu Jiang, Yangfeng Wang, Huahua Zhang, Yameng Wei, Wanjuan Xue, Zhiying Pu, Yi Gao, Dan Li, Yun Feng, Jing Yan & Jing Zhang
Pages: 10535-10545
Published online: 02 Dec 2019
AbstractforMicroRNA-497-5p Induces Cell Cycle Arrest Of Cervical Cancer Cells In S Phase By Targeting CBX4 | Full Text | References | PDF (7.6 MB)
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Article
Docosahexaenoic Acid Serving As Sensitizing Agents And Gefitinib Resistance Revertants In EGFR Targeting Treatment
Xuansheng Ding, Lei Ge, Aiwen Yan, Yuyin Ding, Junye Tao, Qianqian Liu & Chen Qiao
Pages: 10547-10558
Published online: 02 Dec 2019
AbstractforDocosahexaenoic Acid Serving As Sensitizing Agents And Gefitinib Resistance Revertants In EGFR Targeting Treatment | Full Text | References | PDF (9.8 MB)
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Article
Pseudo-Progression and the Neutrophil-to-Lymphocyte Ratio in Non-Small Cell Lung Cancer Treated with Immune Checkpoint Inhibitors: A Case–Control Study
Tatsunori Kiriu, Masatsugu Yamamoto, Tatsuya Nagano, Daisuke Hazama, Reina Sekiya, Masahiro Katsurada, Naoko Katsurada, Motoko Tachihara, Kazuyuki Kobayashi & Yoshihiro Nishimura
Pages: 10559-10568
Published online: 02 Dec 2019
AbstractforPseudo-Progression and the Neutrophil-to-Lymphocyte Ratio in Non-Small Cell Lung Cancer Treated with Immune Checkpoint Inhibitors: A Case–Control Study | Full Text | References | PDF (1.8 MB)
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Article
LINC00096 Promotes the Proliferation and Invasion by Sponging miR-383-5p and Regulating RBM3 Expression in Triple-Negative Breast Cancer
Yanyan Tian, Shuguan Xia, Mingde Ma & Yonggang Zuo
Pages: 10569-10578
Published online: 02 Dec 2019
AbstractforLINC00096 Promotes the Proliferation and Invasion by Sponging miR-383-5p and Regulating RBM3 Expression in Triple-Negative Breast Cancer | Full Text | References | PDF (7.1 MB)
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Article
Apatinib Plus Temozolomide for Recurrent Glioblastoma: An Uncontrolled, Open-Label Study
Yong Wang, Xiangji Meng, Shizhen Zhou, Yufang Zhu, Jun Xu & Rongjie Tao
Pages: 10579-10585
Published online: 03 Dec 2019
AbstractforApatinib Plus Temozolomide for Recurrent Glioblastoma: An Uncontrolled, Open-Label Study | Full Text | References | PDF (2.3 MB)
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Article
A Retrospective Analysis: A Novel Index Predicts Survival and Risk-Stratification for Bone Destruction in 419 Newly Diagnosed Multiple Myelomas
Yanxia Jin, Yufeng Shang, Hailing Liu, Lu Ding, Xiqin Tong, Honglei Tu, Guolin Yuan & Fuling Zhou
Pages: 10587-10596
Published online: 03 Dec 2019
AbstractforA Retrospective Analysis: A Novel Index Predicts Survival and Risk-Stratification for Bone Destruction in 419 Newly Diagnosed Multiple Myelomas | Full Text | References | PDF (3.8 MB)
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Review

Review Article
Nucleic Acid Aptamer: A Novel Potential Diagnostic and Therapeutic Tool for Leukemia
Yuan Tan, Yuejin Li & Faqing Tang
Pages: 10597-10613
Published online: 04 Dec 2019
AbstractforNucleic Acid Aptamer: A Novel Potential Diagnostic and Therapeutic Tool for Leukemia | Full Text | References | PDF (1.7 MB)
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Original Research

Article
Piwi-Interacting RNA1037 Enhances Chemoresistance and Motility in Human Oral Squamous Cell Carcinoma Cells
Guanghui Li, Xi Wang, Chunmei Li, Shuang Hu, Zhixing Niu, Qiang Sun & Minglei Sun
Pages: 10615-10627
Published online: 04 Dec 2019
AbstractforPiwi-Interacting RNA1037 Enhances Chemoresistance and Motility in Human Oral Squamous Cell Carcinoma Cells | Full Text | References | PDF (2.7 MB)
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Article
NEDD4 Negatively Regulates GITR via Ubiquitination in Immune Microenvironment of Melanoma
Yu Guo, Lichang Yang, Shaorong Lei, Wuyuan Tan & Jianhong Long
Pages: 10629-10637
Published online: 04 Dec 2019
AbstractforNEDD4 Negatively Regulates GITR via Ubiquitination in Immune Microenvironment of Melanoma | Full Text | References | PDF (5.2 MB)
  • 25 Views
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Article
Osteoglycin (OGN) Inhibits Cell Proliferation and Invasiveness in Breast Cancer via PI3K/Akt/mTOR Signaling Pathway
Tao Xu, Rui Zhang, Menglu Dong, Zeyu Zhang, Hanning Li, Chenao Zhan & Xingrui Li
Pages: 10639-10650
Published online: 04 Dec 2019
AbstractforOsteoglycin (OGN) Inhibits Cell Proliferation and Invasiveness in Breast Cancer via PI3K/Akt/mTOR Signaling Pathway | Full Text | References | PDF (9.6 MB)
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Article
13-[CH2CO-Cys-(Bzl)-OBzl]-Berberine: Exploring The Correlation Of Anti-Tumor Efficacy With ROS And Apoptosis Protein
Guanyu Li, Yi Ren, Xiaoyi Zhang, Shurui Zhao, Yaonan Wang, Jianhui Wu, Shiqi Peng & Ming Zhao
Pages: 10651-10662
Published online: 05 Dec 2019
Abstractfor13-[CH2CO-Cys-(Bzl)-OBzl]-Berberine: Exploring The Correlation Of Anti-Tumor Efficacy With ROS And Apoptosis Protein | Full Text | References | PDF (8.7 MB)
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Article
Cobalt Chloride Induced Apoptosis by Inhibiting GPC3 Expression via the HIF-1α/c-Myc Axis in HepG2 Cells
Yaoyao Tong, Kun Tong, Qinghong Zhu, Yuqin Wu, Yi Yang, Jicai Zhang, Pei Hu & Shirong Yan
Pages: 10663-10670
Published online: 05 Dec 2019
AbstractforCobalt Chloride Induced Apoptosis by Inhibiting GPC3 Expression via the HIF-1α/c-Myc Axis in HepG2 Cells | Full Text | References | PDF (4.5 MB)
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Article
Long Non-Coding RNA HULC Promotes the Development of Breast Cancer Through Regulating LYPD1 Expression by Sponging miR-6754-5p
Nan Wang, Chaochao Zhong, Mingti Fu, Lin Li, Fang Wang, Pengwei Lv, Mingzhi Zhu, Youyi Xiong, Hailong Mi & Yuanting Gu
Pages: 10671-10679
Published online: 05 Dec 2019
AbstractforLong Non-Coding RNA HULC Promotes the Development of Breast Cancer Through Regulating LYPD1 Expression by Sponging miR-6754-5p | Full Text | References | PDF (7.3 MB)
  • 33 Views
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Article
Long Noncoding RNA LINC00265 Targets EGFR and Promotes Deterioration of Colorectal Cancer: A Comprehensive Study Based on Data Mining and in vitro Validation
Hua Ge, Yan Yan, Chaosen Yue, Chaojie Liang & Jixiang Wu
Pages: 10681-10692
Published online: 05 Dec 2019
AbstractforLong Noncoding RNA LINC00265 Targets EGFR and Promotes Deterioration of Colorectal Cancer: A Comprehensive Study Based on Data Mining and in vitro Validation | Full Text | References | PDF (8.7 MB)
  • 30 Views
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Article
TRIM44 Promotes Colorectal Cancer Proliferation, Migration, and Invasion Through the Akt/mTOR Signaling Pathway
Chun-guang Li, Hang Hu, Xiao-jun Yang, Chao-qun Huang & Xue-qiao Yu
Pages: 10693-10701
Published online: 09 Dec 2019
AbstractforTRIM44 Promotes Colorectal Cancer Proliferation, Migration, and Invasion Through the Akt/mTOR Signaling Pathway | Full Text | References | PDF (5.2 MB)
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Article
NRAS Contributes to Retinoblastoma Progression Through SNHG16/miR-183-5p/NRAS Regulatory Network
Guangli Sun, Gang Su, Fang Liu & Wenjie Han
Pages: 10703-10715
Published online: 06 Dec 2019
AbstractforNRAS Contributes to Retinoblastoma Progression Through SNHG16/miR-183-5p/NRAS Regulatory Network | Full Text | References | PDF (11.8 MB)
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Article
Long Noncoding RNA RP5-833A20.1 Suppresses Tumorigenesis In Hepatocellular Carcinoma Through Akt/ERK Pathway By Targeting miR-18a-5p
Zili Chen, Yifei Ma, Yaozhen Pan, Shi Zuo, Haitao Zhu, Chao Yu, Changhao Zhu & Chengyi Sun
Pages: 10717-10726
Published online: 06 Dec 2019
AbstractforLong Noncoding RNA RP5-833A20.1 Suppresses Tumorigenesis In Hepatocellular Carcinoma Through Akt/ERK Pathway By Targeting miR-18a-5p | Full Text | References | PDF (5.6 MB)
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Article
miR-139 Controls Viability Of Ovarian Cancer Cells Through Apoptosis Induction And Exosome Shedding Inhibition By Targeting ATP7A
Fang Xiao, Songshu Xiao & Min Xue
Pages: 10727-10737
Published online: 06 Dec 2019
AbstractformiR-139 Controls Viability Of Ovarian Cancer Cells Through Apoptosis Induction And Exosome Shedding Inhibition By Targeting ATP7A | Full Text | References | PDF (7 MB)
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Article
Low Expression of ASK1-Interacting Protein-1 Is Significantly Correlated with Tumor Angiogenesis and Poor Survival in Patients with Early Stage Non-Small Cell Lung Cancer
Chengyu Chen, Qun Geng, Dongfeng Sun, Wensi Hu, Chenxi Zhong, Limin Fan & Xiaoming Song
Pages: 10739-10747
Published online: 10 Dec 2019
AbstractforLow Expression of ASK1-Interacting Protein-1 Is Significantly Correlated with Tumor Angiogenesis and Poor Survival in Patients with Early Stage Non-Small Cell Lung Cancer | Full Text | References | PDF (3.3 MB)
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Article
Baicalein, as a Prooxidant, Triggers Mitochondrial Apoptosis in MCF-7 Human Breast Cancer Cells Through Mobilization of Intracellular Copper and Reactive Oxygen Species Generation
Zheng-Hong Liu, Cheng-Xi Yang, Lei Zhang, Cong-Ying Yang & Xiu-Quan Xu
Pages: 10749-10761
Published online: 09 Dec 2019
AbstractforBaicalein, as a Prooxidant, Triggers Mitochondrial Apoptosis in MCF-7 Human Breast Cancer Cells Through Mobilization of Intracellular Copper and Reactive Oxygen Species Generation | Full Text | References | PDF (2.3 MB)
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Case Report

Case Report
Low-Grade Chondrosarcoma In The Sellar Area: Case Report And Literature Review
Zhen Zhang, Li-Juan Pang, Ning Wang, Zhong Li, Yu-Wen Cao, Wen-Hao Hu, Wei-Hua Liang, Jin-Fang Jiang, Hong Zou & Yan Qi
Pages: 10763-10770
Published online: 10 Dec 2019
AbstractforLow-Grade Chondrosarcoma In The Sellar Area: Case Report And Literature Review | Full Text | References | PDF (2.5 MB)
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Original Research

Article
Knockdown of SLC35F2 Inhibits the Proliferation and Metastasis of Bladder Cancer Cells
Mei Chen, Xin Gao, Denggao Huang, Shunlan Wang, Linlin Zheng, Yinyi Chen, Xiaohong Wen, Yuanhui Gao, Hui Cao & Shufang Zhang
Pages: 10771-10786
Published online: 10 Dec 2019
AbstractforKnockdown of SLC35F2 Inhibits the Proliferation and Metastasis of Bladder Cancer Cells | Full Text | References | PDF (12.3 MB)
  • 124 Views
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Article
Long Noncoding RNA KCNQ1OT1 Promotes the Progression of Non-Small Cell Lung Cancer via Regulating miR-204-5p/ATG3 Axis
Yan Kang, Yaoli Jia, Qilong Wang, Qianru Zhao, Meng Song, Ran Ni & Jing Wang
Pages: 10787-10797
Published online: 10 Dec 2019
AbstractforLong Noncoding RNA KCNQ1OT1 Promotes the Progression of Non-Small Cell Lung Cancer via Regulating miR-204-5p/ATG3 Axis | Full Text | References | PDF (7.6 MB)
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Article
MicroRNA-145 Inhibits Cell Migration and Invasion in Colorectal Cancer by Targeting TWIST
Xuning Shen, Honggang Jiang, Zhiheng Chen, Bohao Lu, Yi Zhu, Jiayan Mao, Kequn Chai & Wei Chen
Pages: 10799-10809
Published online: 10 Dec 2019
AbstractforMicroRNA-145 Inhibits Cell Migration and Invasion in Colorectal Cancer by Targeting TWIST | Full Text | References | PDF (9.5 MB)
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Article
Camellia nitidissima Chi Extract Potentiates the Sensitivity of Gastric Cancer Cells to Paclitaxel via the Induction of Autophagy and Apoptosis
Xu He, Hang Li, Meixiao Zhan, Hongyang Li, Aiqun Jia, Sensen Lin, Li Sun, Hongzhi Du, Shengtao Yuan & Yong Li
Pages: 10811-10825
Published online: 11 Dec 2019
AbstractforCamellia nitidissima Chi Extract Potentiates the Sensitivity of Gastric Cancer Cells to Paclitaxel via the Induction of Autophagy and Apoptosis | Full Text | References | PDF (8.5 MB)
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Article
Exosomes-Derived Long Non-Coding RNA HOTAIR Reduces Laryngeal Cancer Radiosensitivity by Regulating microRNA-454-3p/E2F2 Axis
Xiangyan Cui, Dong Xiao, Yu Cui & Xin Wang
Pages: 10827-10839
Published online: 11 Dec 2019
AbstractforExosomes-Derived Long Non-Coding RNA HOTAIR Reduces Laryngeal Cancer Radiosensitivity by Regulating microRNA-454-3p/E2F2 Axis | Full Text | References | PDF (10.2 MB)
  • 31 Views
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Article
Biological Functions of TNKS1 and Its Relationship with Wnt/β-Catenin Pathway in Astrocytoma
Min Chen, Bin Tang, Shenhao Xie, Jian Yan, Le Yang, Xinhui Zhou & Erming Zeng
Pages: 10841-10850
Published online: 11 Dec 2019
AbstractforBiological Functions of TNKS1 and Its Relationship with Wnt/β-Catenin Pathway in Astrocytoma | Full Text | References | PDF (7.2 MB)
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Article
Knockdown of lncRNA HOXA-AS2 Inhibits Viability, Migration and Invasion of Osteosarcoma Cells by miR-124-3p/E2F3
Linyi Wang, Lijuan Wang & Xinhua Zhang
Pages: 10851-10861
Published online: 11 Dec 2019
AbstractforKnockdown of lncRNA HOXA-AS2 Inhibits Viability, Migration and Invasion of Osteosarcoma Cells by miR-124-3p/E2F3 | Full Text | References | PDF (9.1 MB)
  • 23 Views
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Article
Knockdown of lncRNA TDRG1 Inhibits Tumorigenesis in Endometrial Carcinoma Through the PI3K/AKT/mTOR Pathway
Ruimei Sun, Xiujiang Sun, Hua Liu & Peirui Li
Pages: 10863-10872
Published online: 11 Dec 2019
AbstractforKnockdown of lncRNA TDRG1 Inhibits Tumorigenesis in Endometrial Carcinoma Through the PI3K/AKT/mTOR Pathway | Full Text | References | PDF (3.9 MB)
  • 32 Views
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Article
miR-181a Upregulation Promotes Radioresistance of Nasopharyngeal Carcinoma by Targeting RKIP
Wei Huang, Jie Liu, Shanbiao Hu, Guangqing Shi, Zhong Yong, Jian Li, Juan Qiu, Yan Cao & Li Yuan
Pages: 10873-10884
Published online: 11 Dec 2019
AbstractformiR-181a Upregulation Promotes Radioresistance of Nasopharyngeal Carcinoma by Targeting RKIP | Full Text | References | PDF (7.8 MB)
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Article
20(R)-Ginsenoside Rg3 Influences Cancer Stem Cell Properties and the Epithelial-Mesenchymal Transition in Colorectal Cancer via the SNAIL Signaling Axis
Lan Thi Hanh Phi, Yoseph Toni Wijaya, Ita Novita Sari, Kwang Seock Kim, Ying-Gui Yang, Min-Woo Lee & Hyog Young Kwon
Pages: 10885-10895
Published online: 11 Dec 2019
Abstractfor20(R)-Ginsenoside Rg3 Influences Cancer Stem Cell Properties and the Epithelial-Mesenchymal Transition in Colorectal Cancer via the SNAIL Signaling Axis | Full Text | References | PDF (6.2 MB)
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Case Report

Case Report
Response to Afatinib in a Patient with Non-Small Cell Lung Cancer Harboring HER2 R896G Mutation: A Case Report
Ling Lin, Hongfei Ge, Zhengqing Yan, Guoqiang Wang, Xiaomai Wu & Dongqing Lv
Pages: 10897-10902
Published online: 12 Dec 2019
AbstractforResponse to Afatinib in a Patient with Non-Small Cell Lung Cancer Harboring HER2 R896G Mutation: A Case Report | Full Text | References | PDF (2.8 MB)
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Review

Review Article
DNA Methyltransferase Inhibitors: Catalysts For Antitumour Immune Responses
Huimin Dan, Shanshan Zhang, Yongning Zhou & Quanlin Guan
Pages: 10903-10916
Published online: 12 Dec 2019
AbstractforDNA Methyltransferase Inhibitors: Catalysts For Antitumour Immune Responses | Full Text | References | PDF (3.4 MB)
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Original Research

Article
Triterpenoid Saponins from Anemone flaccida Suppress Tumor Cell Proliferation by Regulating MAPK, PD1/PDL1, and STAT3 Signaling Pathways and Altering Cancer Metabolism
Lintao Han, Shiqi Yao, Sa Cao, Guoyan Mo, Jingjing Li, Yan Cao & Fang Huang
Pages: 10917-10930
Published online: 12 Dec 2019
AbstractforTriterpenoid Saponins from Anemone flaccida Suppress Tumor Cell Proliferation by Regulating MAPK, PD1/PDL1, and STAT3 Signaling Pathways and Altering Cancer Metabolism | Full Text | References | PDF (11.8 MB)
  • 36 Views
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Article
PRKD2 Promotes Progression and Chemoresistance of AML via Regulating Notch1 Pathway
Qian Liu, Wei Li, Ying Zhou, Jimo Jian, Shijie Han, Chao Liu, Wei Li, Xunxun Zhu, Daoxin Ma, Min Ji & Chunyan Ji
Pages: 10931-10941
Published online: 12 Dec 2019
AbstractforPRKD2 Promotes Progression and Chemoresistance of AML via Regulating Notch1 Pathway | Full Text | References | PDF (7.1 MB)
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Article
LncRNA RP11-422N16.3 Inhibits Cell Proliferation and EMT, and Induces Apoptosis in Hepatocellular Carcinoma Cells by Sponging miR-23b-3p
Yunpeng Sun, Qingqing Zhou, Junjian Li, Chang Zhao, Zhengping Yu & Qiandong Zhu
Pages: 10943-10961
Published online: 12 Dec 2019
AbstractforLncRNA RP11-422N16.3 Inhibits Cell Proliferation and EMT, and Induces Apoptosis in Hepatocellular Carcinoma Cells by Sponging miR-23b-3p | Full Text | References | PDF (13.9 MB)
  • 27 Views
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Article
Long Non-Coding RNA BCAR4 Promotes Growth, Invasion and Tumorigenicity by Targeting miR-2276 to Upregulate MMP7 Expression in Glioma
Zhifeng Wang, Longlong Wang, Zan Liang & Yanguo Xi
Pages: 10963-10973
Published online: 12 Dec 2019
AbstractforLong Non-Coding RNA BCAR4 Promotes Growth, Invasion and Tumorigenicity by Targeting miR-2276 to Upregulate MMP7 Expression in Glioma | Full Text | References | PDF (6.1 MB)
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Article
miR-449a Is Related to Short-Term Recurrence of Hepatocellular Carcinoma and Inhibits Migration and Invasion by Targeting Notch1
Bing Han, Jiawei Huang, Zhenjie Yang, Jiaqi Zhang, Xiaomin Wang, Ning Xu, Haining Meng, Junyu Wu, Qiao Huang, Xi Yang, Ruowu Shen & Chuandong Sun
Pages: 10975-10987
Published online: 13 Dec 2019
AbstractformiR-449a Is Related to Short-Term Recurrence of Hepatocellular Carcinoma and Inhibits Migration and Invasion by Targeting Notch1 | Full Text | References | PDF (9.7 MB)
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Case Report

Case Report
Durable Molecular Remission in a Lymphoid BP-CML Patient Harboring T315I Mutation Treated with Anti-CD19 CAR-T Therapy
Lu Zhou, Huiping Shi, Wenyu Shi, Li Yang, Yaping Zhang, Mengqi Xu, Xiufang Chen, Yanv Zhu, Hui Mu, Xiaochun Wan, Zhonghua Yang, Ying Zeng & Hong Liu
Pages: 10989-10995
Published online: 13 Dec 2019
AbstractforDurable Molecular Remission in a Lymphoid BP-CML Patient Harboring T315I Mutation Treated with Anti-CD19 CAR-T Therapy | Full Text | References | PDF (923.3 KB)
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Original Research

Article
LncRNA HOTAIRM1/HOXA1 Axis Promotes Cell Proliferation, Migration And Invasion In Endometrial Cancer
Xianli Li, Li Pang, Zhuo Yang, Jing Liu, Weishan Li & Danbo Wang
Pages: 10997-11015
Published online: 13 Dec 2019
AbstractforLncRNA HOTAIRM1/HOXA1 Axis Promotes Cell Proliferation, Migration And Invasion In Endometrial Cancer | Full Text | References | PDF (8.1 MB)
  • 49 Views
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Article
The Down-Regulation of lncRNA PCAT18 Promotes the Progression of Gastric Cancer via MiR-107/PTEN/PI3K/AKT Signaling Pathway
Ping Chen, Xiaoyong Zhao, Hui Wang, Mengdan Zheng, Qinghua Wang & Wenjuan Chang
Pages: 11017-11031
Published online: 13 Dec 2019
AbstractforThe Down-Regulation of lncRNA PCAT18 Promotes the Progression of Gastric Cancer via MiR-107/PTEN/PI3K/AKT Signaling Pathway | Full Text | References | PDF (11.7 MB)
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Review

Review Article
Cancer Immunotherapies Targeting Tumor-Associated Regulatory T Cells
Xiaoxu Ge, Yamei Zhao, Chao Chen, Jian Wang & Lifeng Sun
Pages: 11033-11044
Published online: 13 Dec 2019
AbstractforCancer Immunotherapies Targeting Tumor-Associated Regulatory T Cells | Full Text | References | PDF (2 MB)
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Original Research

Article
Oncogenic Role and Prognostic Value of MicroRNA-937-3p in Patients with Breast Cancer
Deyu Li, Jiangming Zhong, Guifeng Zhang, Li Lin & Zhenhua Liu
Pages: 11045-11056
Published online: 13 Dec 2019
AbstractforOncogenic Role and Prognostic Value of MicroRNA-937-3p in Patients with Breast Cancer | Full Text | References | PDF (8.8 MB)
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Article
Knockdown Of lncRNA NCK-AS1 Regulates Cisplatin Resistance Through Modulating miR-137 In Osteosarcoma Cells
Yi Cheng, Xiaofei Shen, Minqian Zheng, Guoyou Zou & Yixin Shen
Pages: 11057-11068
Published online: 16 Dec 2019
AbstractforKnockdown Of lncRNA NCK-AS1 Regulates Cisplatin Resistance Through Modulating miR-137 In Osteosarcoma Cells | Full Text | References | PDF (12.5 MB)
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Review

Review Article
miR-451: A Novel Biomarker and Potential Therapeutic Target for Cancer
Hua Bai & Suhui Wu
Pages: 11069-11082
Published online: 16 Dec 2019
AbstractformiR-451: A Novel Biomarker and Potential Therapeutic Target for Cancer | Full Text | References | PDF (1.8 MB)
  • 88 Views
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Article
Extrapancreatic Neuropathy Correlates with Early Liver Metastasis in Pancreatic Head Adenocarcinoma
Meng Lu, Dian-rong Xiu, Li-mei Guo, Chun-hui Yuan, Ling-fu Zhang & Lian-yuan Tao
Pages: 11083-11095
Published online: 16 Dec 2019
AbstractforExtrapancreatic Neuropathy Correlates with Early Liver Metastasis in Pancreatic Head Adenocarcinoma | Full Text | References | PDF (5.4 MB)
  • 24 Views
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Article
miR-7 Reverses Breast Cancer Resistance To Chemotherapy By Targeting MRP1 And BCL2
Tianzi Hong, Jian Ding & Wenlian Li
Pages: 11097-11105
Published online: 16 Dec 2019
AbstractformiR-7 Reverses Breast Cancer Resistance To Chemotherapy By Targeting MRP1 And BCL2 | Full Text | References | PDF (4.8 MB)
  • 56 Views
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Article
CDK4/6 Inhibitor Palbociclib Amplifies the Radiosensitivity to Nasopharyngeal Carcinoma Cells via Mediating Apoptosis and Suppressing DNA Damage Repair
Xianhe Xie, Weili Zheng, Ting Chen, Wanzun Lin, Ziyuan Liao, Junjin Liu & Yin Ding
Pages: 11107-11117
Published online: 16 Dec 2019
AbstractforCDK4/6 Inhibitor Palbociclib Amplifies the Radiosensitivity to Nasopharyngeal Carcinoma Cells via Mediating Apoptosis and Suppressing DNA Damage Repair | Full Text | References | PDF (7.9 MB)
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Article
LncRNA LINC00461 Promotes Colorectal Cancer Progression via miRNA-323b-3p/NFIB Axis
Hairong Yu, Jianguo Ma, Jianshuang Chen, Yang Yang, Jianjing Liang & Yulong Liang
Pages: 11119-11129
Published online: 17 Dec 2019
AbstractforLncRNA LINC00461 Promotes Colorectal Cancer Progression via miRNA-323b-3p/NFIB Axis | Full Text | References | PDF (6.6 MB)
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Review

Review Article
Oral Microbiota as Promising Diagnostic Biomarkers for Gastrointestinal Cancer: A Systematic Review
Yanwei Chen, Xuechen Chen, Haixin Yu, Haibo Zhou & Shu Xu
Pages: 11131-11144
Published online: 18 Dec 2019
AbstractforOral Microbiota as Promising Diagnostic Biomarkers for Gastrointestinal Cancer: A Systematic Review | Full Text | References | PDF (1.2 MB)
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Case Report

Case Report
Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report
Jibing Chen, Feng Mu, Tianyu Lu, Duanming Du & Kecheng Xu
Pages: 11145-11151
Published online: 17 Dec 2019
AbstractforBrain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report | Full Text | References | PDF (3.9 MB)
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Original Research

Article
Impact of Fucosylation on Self-Assembly of Prostate and Breast Tumor Spheroids by Using Cyclo-RGDfK(TPP) Peptide and Image Object Detection
Regina-Veronicka Kalaydina, Hedi Zhou, Elena Markvicheva, Sergey V Burov, Farhana Zulkernine & Myron R Szewczuk
Pages: 11153-11173
Published online: 17 Dec 2019
AbstractforImpact of Fucosylation on Self-Assembly of Prostate and Breast Tumor Spheroids by Using Cyclo-RGDfK(TPP) Peptide and Image Object Detection | Full Text | References | PDF (18.9 MB)
  • 43 Views
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Article
Notch Intracellular Domain (NICD) Expression and Clinical Manifestations of Second Primary Tumor at Esophagus in Patients with Head and Neck Squamous Cell Carcinoma
Tauangtham Anekpuritanang, Warut Pongsapich, Tanasarun Watcharadilokkul, Premyot Ngaotepprutaram, Paveena Pithuksurachai & Sacarin Bunbanjerdsuk
Pages: 11175-11181
Published online: 17 Dec 2019
AbstractforNotch Intracellular Domain (NICD) Expression and Clinical Manifestations of Second Primary Tumor at Esophagus in Patients with Head and Neck Squamous Cell Carcinoma | Full Text | References | PDF (893.6 KB)
  • 23 Views
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Article
Baicalin Inhibits Cell Viability, Migration and Invasion in Breast Cancer by Regulating miR-338-3p and MORC4
Xin Duan, Guangcheng Guo, Xinhong Pei, Xinxing Wang, Lin Li, Youyi Xiong & Xinguang Qiu
Pages: 11183-11193
Published online: 17 Dec 2019
AbstractforBaicalin Inhibits Cell Viability, Migration and Invasion in Breast Cancer by Regulating miR-338-3p and MORC4 | Full Text | References | PDF (6.5 MB)
  • 37 Views
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Article
Long Non-Coding RNA HOXA11-AS Promotes Non-Small Cell Lung Cancer Tumorigenesis Through microRNA-148a-3p/DNMT1 Regulatory Axis
Yue Bai, Lili Lang, Wentao Zhao & Rong Niu
Pages: 11195-11206
Published online: 17 Dec 2019
AbstractforLong Non-Coding RNA HOXA11-AS Promotes Non-Small Cell Lung Cancer Tumorigenesis Through microRNA-148a-3p/DNMT1 Regulatory Axis | Full Text | References | PDF (6.6 MB)
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Article
MTF2 Induces Epithelial-Mesenchymal Transition and Progression of Hepatocellular Carcinoma by Transcriptionally Activating Snail
Tian-Tian Wu, Jun Cai, Yuan-Hu Tian, Jian-Fei Chen, Zhi-Lei Cheng, Chang-Sheng Pu, Wen-Zai Shi, Xiao-Peng Suo, Xian-Jia Wu, Xiao-Wei Dou & Ke-Ming Zhang
Pages: 11207-11220
Published online: 17 Dec 2019
AbstractforMTF2 Induces Epithelial-Mesenchymal Transition and Progression of Hepatocellular Carcinoma by Transcriptionally Activating Snail | Full Text | References | PDF (9.6 MB)
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Article
RNA-Seq Analysis Identified XLOC_009190 as Potential Therapeutic Target for Lung Adenocarcinoma
Jing Wang, Ning Wang, Wei-dong Zhao, Li-xian Zhao, Yong-guang Jing, Li-jie Yang, Jie He & Jun Li
Pages: 11221-11229
Published online: 18 Dec 2019
AbstractforRNA-Seq Analysis Identified XLOC_009190 as Potential Therapeutic Target for Lung Adenocarcinoma | Full Text | References | PDF (7.5 MB)
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Article
Aberrant Expression of miR-592 Is Associated with Prognosis and Progression of Renal Cell Carcinoma
Xianbao Lv, Jingang Shen, Zhen Guo, Lingwei Kong, Guangchun Zhou & Hao Ning
Pages: 11231-11239
Published online: 18 Dec 2019
AbstractforAberrant Expression of miR-592 Is Associated with Prognosis and Progression of Renal Cell Carcinoma | Full Text | References | PDF (669.3 KB)
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Article
RETRACTED ARTICLE: Upregulated miR-27a-3p Indicates a Poor Prognosis in Pancreatic Carcinoma Patients and Promotes the Angiogenesis and Migration by Epigenetic Silencing of GATA6 and Activating VEGFA/VEGFR2 Signaling Pathway
Xuefeng Rao, Lihui Wan, Zhigang Jie, Xiaoliang Zhu, Junxiang Yin & Hong Cao
Pages: 11241-11254
Published online: 19 Dec 2019
AbstractforRETRACTED ARTICLE: Upregulated miR-27a-3p Indicates a Poor Prognosis in Pancreatic Carcinoma Patients and Promotes the Angiogenesis and Migration by Epigenetic Silencing of GATA6 and Activating VEGFA/VEGFR2 Signaling Pathway | PDF (10.1 MB)
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Article
Demethylation and Overexpression of CSF2 are Involved in Immune Response, Chemotherapy Resistance, and Poor Prognosis in Colorectal Cancer
Zongbin Xu, Yiyi Zhang, Meifang Xu, Xin Zheng, Mengxin Lin, Jie Pan, Chengwei Ye, Yu Deng, Caiyun Jiang, Yu Lin, Xingrong Lu & Pan Chi
Pages: 11255-11269
Published online: 19 Dec 2019
AbstractforDemethylation and Overexpression of CSF2 are Involved in Immune Response, Chemotherapy Resistance, and Poor Prognosis in Colorectal Cancer | Full Text | References | PDF (11 MB)
  • 39 Views
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Article
MicroRNA-432 Suppresses Invasion and Migration via E2F3 in Nasopharyngeal Carcinoma
Tingting Wang, Mingyu Du, Wenjun Zhang, Hui Bai, Li Yin, Wei Chen, Xia He & Qi Chen
Pages: 11271-11280
Published online: 19 Dec 2019
AbstractforMicroRNA-432 Suppresses Invasion and Migration via E2F3 in Nasopharyngeal Carcinoma | Full Text | References | PDF (7.9 MB)
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Article
MAGI1 Inhibits the Proliferation, Migration and Invasion of Glioma Cells
Zhong-Yan Li, Xue-Hua Li, Guang-Wei Tian, Dong-Yong Zhang, Hai Gao & Zhen-Yu Wang
Pages: 11281-11290
Published online: 19 Dec 2019
AbstractforMAGI1 Inhibits the Proliferation, Migration and Invasion of Glioma Cells | Full Text | References | PDF (12.4 MB)
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Review

Review Article
Ferroptosis in Carcinoma: Regulatory Mechanisms and New Method for Cancer Therapy
Zhi-Zhou Shi, Ze-Wen Fan, Yun-Xia Chen, Xiu-Feng Xie, Wen Jiang, Wen-Jun Wang, Yun-Tan Qiu & Jie Bai
Pages: 11291-11304
Published online: 19 Dec 2019
AbstractforFerroptosis in Carcinoma: Regulatory Mechanisms and New Method for Cancer Therapy | Full Text | References | PDF (3.7 MB)
  • 66 Views
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Case Report

Case Report
Third-Generation TKI Resistance Due to SCLC Transformation: A Case Report and Brief Review
Shen Chen, Yayi He, Juan Liu, Xiaoxia Chen, Jia Yu, Wei Li, Bin Chen, Chenglong Sun & Caicun Zhou
Pages: 11305-11311
Published online: 19 Dec 2019
AbstractforThird-Generation TKI Resistance Due to SCLC Transformation: A Case Report and Brief Review | Full Text | References | PDF (5.4 MB)
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Original Research

Article
miR-30a-3p Targets MAD2L1 and Regulates Proliferation of Gastric Cancer Cells
Yu Wang, Fenghui Wang, Jing He, Juan Du, Huahua Zhang, Haiyan Shi, Yani Chen, Yameng Wei, Wanjuan Xue, Jing Yan, Yun Feng, Yi Gao, Dan Li, Jiming Han & Jing Zhang
Pages: 11313-11324
Published online: 19 Dec 2019
AbstractformiR-30a-3p Targets MAD2L1 and Regulates Proliferation of Gastric Cancer Cells | Full Text | References | PDF (5.8 MB)
  • 115 Views
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Article
Exosome-Mediated Transfer of lncRNA HOTTIP Promotes Cisplatin Resistance in Gastric Cancer Cells by Regulating HMGA1/miR-218 Axis
Jingyu Wang, Baojun Lv, Yonghui Su, Xiao Wang, Juyuan Bu & Lan Yao
Pages: 11325-11338
Published online: 20 Dec 2019
AbstractforExosome-Mediated Transfer of lncRNA HOTTIP Promotes Cisplatin Resistance in Gastric Cancer Cells by Regulating HMGA1/miR-218 Axis | Full Text | References | PDF (7.6 MB)
  • 37 Views
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Case Report

Case Report
Application of Somatostatin, Chemotherapy Combined with TAE in Heterogeneous Glucagonoma Presented with Necrolytic Migratory Erythema
Chaoyong Shen, Jiaoxue He, Xiaoyan Le, Linmao Zheng & Dan Cao
Pages: 11339-11344
Published online: 20 Dec 2019
AbstractforApplication of Somatostatin, Chemotherapy Combined with TAE in Heterogeneous Glucagonoma Presented with Necrolytic Migratory Erythema | Full Text | References | PDF (8.3 MB)
  • 35 Views
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Original Research

Article
RETRACTED ARTICLE: LOXL1-AS1 Drives The Progression Of Gastric Cancer Via Regulating miR-142-5p/PIK3CA Axis
Ming Li, Ou Cai & Shiyun Tan
Pages: 11345-11357
Published online: 20 Dec 2019
AbstractforRETRACTED ARTICLE: LOXL1-AS1 Drives The Progression Of Gastric Cancer Via Regulating miR-142-5p/PIK3CA Axis | PDF (8.6 MB)
  • 8 Views
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Article
Cystatin SN Affects Cell Proliferation by Regulating the ERα/PI3K/AKT/ERα Loopback Pathway in Breast Cancer
Yanfang Liu, Hong Ma, Ye Wang, Xinyang Du & Jing Yao
Pages: 11359-11369
Published online: 23 Dec 2019
AbstractforCystatin SN Affects Cell Proliferation by Regulating the ERα/PI3K/AKT/ERα Loopback Pathway in Breast Cancer | Full Text | References | PDF (15.1 MB)
  • 103 Views
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Article
TMEFF2 inhibits pancreatic cancer cells proliferation, migration, and invasion by suppressing phosphorylation of the MAPK signaling pathway
Hongchao Han, Zhilin Zhan, Jie Xu & Zhenshun Song
Pages: 11371-11382
Published online: 23 Dec 2019
AbstractforTMEFF2 inhibits pancreatic cancer cells proliferation, migration, and invasion by suppressing phosphorylation of the MAPK signaling pathway | Full Text | References | PDF (4.5 MB)
  • 59 Views
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Article
Evodiamine Selectively Inhibits Multiple Myeloma Cell Growth by Triggering Activation of Intrinsic Apoptosis Pathway
Qing Fang, Siyi Jiang & Chengyuan Li
Pages: 11383-11391
Published online: 24 Dec 2019
AbstractforEvodiamine Selectively Inhibits Multiple Myeloma Cell Growth by Triggering Activation of Intrinsic Apoptosis Pathway | Full Text | References | PDF (7.9 MB)
  • 31 Views
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Review

Review Article
Research Progress in microRNA-Based Therapy for Gastric Cancer
Xu Zhao, Gao-Feng Hu, Yan-Fen Shi & Wei Xu
Pages: 11393-11411
Published online: 24 Dec 2019
AbstractforResearch Progress in microRNA-Based Therapy for Gastric Cancer | Full Text | References | PDF (553.5 KB)
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Article
A Novel Scoring System Based on Peripheral Blood Test in Predicting Grade and Prognosis of Patients with Glioma
Yiyang Wu, Zimu Song, Kuisheng Sun, Shikuo Rong, Peng Gao, Feng Wang & Tao Sun
Pages: 11413-11423
Published online: 24 Dec 2019
AbstractforA Novel Scoring System Based on Peripheral Blood Test in Predicting Grade and Prognosis of Patients with Glioma | Full Text | References | PDF (4 MB)
  • 37 Views
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Article
miR-762 Promotes Malignant Development of Head and Neck Squamous Cell Carcinoma by Targeting PHLPP2 and FOXO4
Shuai Chen, Jian-Yun Zhang, Li-Sha Sun, Xue-Fen Li, Jia-Ying Bai, He-Yu Zhang & Tie-Jun Li
Pages: 11425-11436
Published online: 24 Dec 2019
AbstractformiR-762 Promotes Malignant Development of Head and Neck Squamous Cell Carcinoma by Targeting PHLPP2 and FOXO4 | Full Text | References | PDF (3.5 MB)
  • 41 Views
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Article
Berbamine Enhances the Efficacy of Gefitinib by Suppressing STAT3 Signaling in Pancreatic Cancer Cells
Bingren Hu, Huajie Cai, Shouzhang Yang, Jinfu Tu, Xiaming Huang & Gang Chen
Pages: 11437-11451
Published online: 24 Dec 2019
AbstractforBerbamine Enhances the Efficacy of Gefitinib by Suppressing STAT3 Signaling in Pancreatic Cancer Cells | Full Text | References | PDF (10.8 MB)
  • 141 Views
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Article
miR-492 Promotes Cancer Progression by Targeting GJB4 and Is a Novel Biomarker for Bladder Cancer
Kai Wang, Hang Lü, Hongchen Qu, Qingpeng Xie, Tao Sun, Ou Gan & Bin Hu
Pages: 11453-11464
Published online: 24 Dec 2019
AbstractformiR-492 Promotes Cancer Progression by Targeting GJB4 and Is a Novel Biomarker for Bladder Cancer | Full Text | References | PDF (12.2 MB)
  • 41 Views
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Article
MiR-195-5p Inhibits Proliferation and Induces Apoptosis of Non-Small Cell Lung Cancer Cells by Targeting CEP55
Jianhua Luo, Junsu Pan, Yan Jin, Mengyuan Li & Miao Chen
Pages: 11465-11474
Published online: 24 Dec 2019
AbstractforMiR-195-5p Inhibits Proliferation and Induces Apoptosis of Non-Small Cell Lung Cancer Cells by Targeting CEP55 | Full Text | References | PDF (5.2 MB)
  • 40 Views
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Article
IRF1 Negatively Regulates Oncogenic KPNA2 Expression Under Growth Stimulation and Hypoxia in Lung Cancer Cells
Jie-Xin Huang, Yi-Cheng Wu, Ya-Yun Cheng, Chih-Liang Wang & Chia-Jung Yu
Pages: 11475-11486
Published online: 27 Dec 2019
AbstractforIRF1 Negatively Regulates Oncogenic KPNA2 Expression Under Growth Stimulation and Hypoxia in Lung Cancer Cells | Full Text | References | PDF (3.7 MB)
  • 36 Views
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Article
LncRNA SNHG5 Promotes Proliferation of Glioma by Regulating miR-205-5p/ZEB2 Axis
Xiangrui Meng, Yanyao Deng, Zhicheng Lv, Chao Liu, Ziqing Guo, Yuan Li, Hua Liu, Bing Xie, Ziqi Jin, Fangbo Lin & Hongwei Zhu
Pages: 11487-11496
Published online: 27 Dec 2019
AbstractforLncRNA SNHG5 Promotes Proliferation of Glioma by Regulating miR-205-5p/ZEB2 Axis | Full Text | References | PDF (4.7 MB)
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Review

Review Article
Role of Olaparib as Maintenance Treatment for Ovarian Cancer: The Evidence to Date
Lauren Montemorano, Michelle DS Lightfoot & Kristin Bixel
Pages: 11497-11506
Published online: 27 Dec 2019
AbstractforRole of Olaparib as Maintenance Treatment for Ovarian Cancer: The Evidence to Date | Full Text | References | PDF (348.1 KB)
  • 70 Views
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Original Research

Article
ARHGAP10 Inhibits the Proliferation and Metastasis of CRC Cells via Blocking the Activity of RhoA/AKT Signaling Pathway
Lin Liu, Dongyu Xie, Haina Xie, Wei Huang, Jingxian Zhang, Wenye Jin, Wenjing Jiang & Donghao Xie
Pages: 11507-11516
Published online: 27 Dec 2019
AbstractforARHGAP10 Inhibits the Proliferation and Metastasis of CRC Cells via Blocking the Activity of RhoA/AKT Signaling Pathway | Full Text | References | PDF (8 MB)
  • 23 Views
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Review

Review Article
Circulating Cell-Free DNA or Circulating Tumor DNA in the Management of Ovarian and Endometrial Cancer
Qian Chen, Zi-Han Zhang, Shu Wang & Jing-He Lang
Pages: 11517-11530
Published online: 27 Dec 2019
AbstractforCirculating Cell-Free DNA or Circulating Tumor DNA in the Management of Ovarian and Endometrial Cancer | Full Text | References | PDF (747.5 KB)
  • 121 Views
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Original Research

Article
Long Non-Coding RNA TTN-AS1 Promotes the Proliferation and Invasion of Colorectal Cancer Cells by Activating miR-497-Mediated PI3K/Akt/mTOR Signaling
Zhenhua Cui, Bingbing Han, Xianren Wang, Zhiwen Li, Jianxin Wang & Yanfeng Lv
Pages: 11531-11539
Published online: 27 Dec 2019
AbstractforLong Non-Coding RNA TTN-AS1 Promotes the Proliferation and Invasion of Colorectal Cancer Cells by Activating miR-497-Mediated PI3K/Akt/mTOR Signaling | Full Text | References | PDF (5.2 MB)
  • 25 Views
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Article
Conformance Assessment of PD-L1 Expression Between Primary Tumour and Nodal Metastases in Non-Small-Cell Lung Cancer
Haipeng Xu, Xueyan Chen, Dong Lin, Jing Zhang, Chao Li, Dianbao Zhang & Xianfen Zhang
Pages: 11541-11547
Published online: 30 Dec 2019
AbstractforConformance Assessment of PD-L1 Expression Between Primary Tumour and Nodal Metastases in Non-Small-Cell Lung Cancer | Full Text | References | PDF (2.8 MB)
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Case Report

Case Report
Primary Prostatic Extra-Gastrointestinal Stromal Tumor Treated with Imatinib Mesylate as Neoadjuvant and Adjuvant Therapy: A Case Report and Literature Review
Haixiang Shen, Zhize Wang, Meibao Feng, Jin Liu, Jiangfeng Li, Xiao Wang & Xin Xu
Pages: 11549-11553
Published online: 30 Dec 2019
AbstractforPrimary Prostatic Extra-Gastrointestinal Stromal Tumor Treated with Imatinib Mesylate as Neoadjuvant and Adjuvant Therapy: A Case Report and Literature Review | Full Text | References | PDF (729.2 KB)
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Article
microRNA-26a-5p Promotes Proliferation and Migration of Osteosarcoma Cells by Targeting HOXA5 in vitro and in vivo
Tianhua Yu, Dexin Chen, Lei Zhang & Daqian Wan
Pages: 11555-11565
Published online: 30 Dec 2019
AbstractformicroRNA-26a-5p Promotes Proliferation and Migration of Osteosarcoma Cells by Targeting HOXA5 in vitro and in vivo | Full Text | References | PDF (8.4 MB)
  • 29 Views
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Article
Prognostic Significance of FKBP14 in Gastric Cancer
Roshan Ara Ghoorun, Xiao-Hua Wu, Hong-Lei Chen, Dong-Lin Ren & Xiao-Bin Wu
Pages: 11567-11577
Published online: 30 Dec 2019
AbstractforPrognostic Significance of FKBP14 in Gastric Cancer | Full Text | References | PDF (6.2 MB)
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Article
Resveratrol Inhibits Proliferation in HBL-52 Meningioma Cells
Shun-an Hu, Wei Wei, Jia Yuan & Jin Cheng
Pages: 11579-11586
Published online: 30 Dec 2019
AbstractforResveratrol Inhibits Proliferation in HBL-52 Meningioma Cells | Full Text | References | PDF (715 KB)
  • 76 Views
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Article
TRIM3 Negatively Regulates Autophagy Through Promoting Degradation of Beclin1 in Ewing Sarcoma Cells
Qunshan Lu, Yuankai Zhang, Liang Ma, Deqiang Li, Ming Li, Peilai Liu & Jianmin Li
Pages: 11587-11595
Published online: 30 Dec 2019
AbstractforTRIM3 Negatively Regulates Autophagy Through Promoting Degradation of Beclin1 in Ewing Sarcoma Cells | Full Text | References | PDF (6.2 MB)
  • 31 Views
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Article
Identification of an Activating Mutation in the Extracellular Domain of HER2 Conferring Resistance to Pertuzumab
Ying Zhang, Shanshan Wu, Xinlei Zhuang, Gaoqi Weng, Jiansheng Fan, Xiaoyue Yang, Yingchun Xu, Liqiang Pan, Tingjun Hou, Zhan Zhou & Shuqing Chen
Pages: 11597-11608
Published online: 30 Dec 2019
AbstractforIdentification of an Activating Mutation in the Extracellular Domain of HER2 Conferring Resistance to Pertuzumab | Full Text | References | PDF (7.1 MB)
  • 55 Views
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Article
Potential Prognostic and Diagnostic Values of CDC6, CDC45, ORC6 and SNHG7 in Colorectal Cancer
Yang Hu, Liping Wang, Zhixing Li, Zirui Wan, Mingjie Shao, Shaobin Wu & Guo Wang
Pages: 11609-11621
Published online: 31 Dec 2019
AbstractforPotential Prognostic and Diagnostic Values of CDC6, CDC45, ORC6 and SNHG7 in Colorectal Cancer | Full Text | References | PDF (8 MB)
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Article
Long Non-Coding RNA EGOT Promotes the Malignant Phenotypes of Hepatocellular Carcinoma Cells and Increases the Expression of HMGA2 via Down-Regulating miR-33a-5p
Shimin Wu, Hongwu Ai, Kehui Zhang, Hao Yun & Fei Xie
Pages: 11623-11635
Published online: 31 Dec 2019
AbstractforLong Non-Coding RNA EGOT Promotes the Malignant Phenotypes of Hepatocellular Carcinoma Cells and Increases the Expression of HMGA2 via Down-Regulating miR-33a-5p | Full Text | References | PDF (9 MB)
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Article
DUXAP8 a Pan-Cancer Prognostic Marker Involved in the Molecular Regulatory Mechanism in Hepatocellular Carcinoma: A Comprehensive Study Based on Data Mining, Bioinformatics, and in vitro Validation
Chaosen Yue, Chaojie Liang, Pengyang Li, Lijun Yan, Dongxin Zhang, Yingchen Xu, Zhigang Wei & Jixiang Wu
Pages: 11637-11650
Published online: 31 Dec 2019
AbstractforDUXAP8 a Pan-Cancer Prognostic Marker Involved in the Molecular Regulatory Mechanism in Hepatocellular Carcinoma: A Comprehensive Study Based on Data Mining, Bioinformatics, and in vitro Validation | Full Text | References | PDF (11.8 MB)
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Article
Water Extract of Sporoderm-Broken Spores of Ganoderma lucidum Induces Osteosarcoma Apoptosis and Restricts Autophagic Flux
Wenkan Zhang, Zhong Lei, Jiahong Meng, Guoqi Li, Yuxiang Zhang, Jiaming He & Weiqi Yan
Pages: 11651-11665
Published online: 31 Dec 2019
AbstractforWater Extract of Sporoderm-Broken Spores of Ganoderma lucidum Induces Osteosarcoma Apoptosis and Restricts Autophagic Flux | Full Text | References | PDF (11.2 MB)
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Article
A Chemotherapy-Driven Increase in Mcl-1 Mediates the Effect of miR-375 on Cisplatin Resistance in Osteosarcoma Cells
An-song Liu, Hai-yang Yu, Yan-lin Yang, Fu-yao Xue, Xia Chen, Yun Zhang, Zi-yu Zhou, Bin Zhang, Lan Li, Chuan-zheng Sun, Peng Huang & Ju-fang Huang
Pages: 11667-11677
Published online: 31 Dec 2019
AbstractforA Chemotherapy-Driven Increase in Mcl-1 Mediates the Effect of miR-375 on Cisplatin Resistance in Osteosarcoma Cells | Full Text | References | PDF (9 MB)
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Review

Review Article
SNHG16: A Novel Long-Non Coding RNA in Human Cancers
Ming Yang & Wenbin Wei
Pages: 11679-11690
Published online: 31 Dec 2019
AbstractforSNHG16: A Novel Long-Non Coding RNA in Human Cancers | Full Text | References | PDF (1.3 MB)
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Original Research

Article
miR-520b Promotes Breast Cancer Stemness Through Hippo/YAP Signaling Pathway
Hui Zhang, Ting-yuan Lang, Dong-ling Zou, Lei Zhou, Meng Lou, Jing-shu Liu, Yun-zhe Li, Dong-yan Ding, Yu-cong Li, Na Zhang, Xiao-dong Zheng, Xiao-hua Zeng, Qi Zhou & Li Li
Pages: 11691-11700
Published online: 31 Dec 2019
AbstractformiR-520b Promotes Breast Cancer Stemness Through Hippo/YAP Signaling Pathway | Full Text | References | PDF (1.4 MB)
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Article
RETRACTED ARTICLE: LncRNA FTX Promotes Proliferation and Invasion of Gastric Cancer via miR-144/ZFX Axis
Hongbo Li, Guoliang Yao, Jingming Zhai, Dingwen Hu & Yonggang Fan
Pages: 11701-11713
Published online: 31 Dec 2019
AbstractforRETRACTED ARTICLE: LncRNA FTX Promotes Proliferation and Invasion of Gastric Cancer via miR-144/ZFX Axis | PDF (15.6 MB)
  • 19 Views
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Article
Effects of Vitamin K3 Combined with UVB on the Proliferation and Apoptosis of Cutaneous Squamous Cell Carcinoma A431 Cells
Shangyuchen Shi, Gang Zheng, Chunsheng Yang, Xi Chen, Qiuyue Yan, Fan Jiang, Xiaojie Jiang, Yong Xin & Guan Jiang
Pages: 11715-11727
Published online: 03 Jan 2020
AbstractforEffects of Vitamin K3 Combined with UVB on the Proliferation and Apoptosis of Cutaneous Squamous Cell Carcinoma A431 Cells | Full Text | References | PDF (7.5 MB)
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Article
Expression and Effects of Long Non-Coding RNA, LINC01124, in Non-Small Cell Lung Cancer
Zi-Bo Wang, Hong-Yan Zhang & Ji-Bin Lu
Pages: 11729-11736
Published online: 03 Jan 2020
AbstractforExpression and Effects of Long Non-Coding RNA, LINC01124, in Non-Small Cell Lung Cancer | Full Text | References | PDF (4.8 MB)
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Article
RETRACTED ARTICLE: MicroRNA-769-5p Inhibits Pancreatic Ductal Adenocarcinoma Progression by Directly Targeting and Downregulating ETS Proto-Oncogene 1
Kai Cheng, Lan Feng, Shuang Yu, Changhong Yu & Nannan Chi
Pages: 11737-11750
Published online: 03 Jan 2020
AbstractforRETRACTED ARTICLE: MicroRNA-769-5p Inhibits Pancreatic Ductal Adenocarcinoma Progression by Directly Targeting and Downregulating ETS Proto-Oncogene 1 | PDF (10.7 MB)
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Article
Berberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake
Pengcheng Zhang, Quancheng Wang, Zhibin Lin, Peijun Yang, Kefeng Dou & Ruohan Zhang
Pages: 11751-11763
Published online: 03 Jan 2020
AbstractforBerberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake | Full Text | References | PDF (12.2 MB)
  • 289 Views
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Article
Midkine Is a Potential Urinary Biomarker for Non-Invasive Detection of Bladder Cancer with Microscopic Hematuria
Hao Lin, Qingwen Zhou, Weichu Wu & Yulin Ma
Pages: 11765-11775
Published online: 03 Jan 2020
AbstractforMidkine Is a Potential Urinary Biomarker for Non-Invasive Detection of Bladder Cancer with Microscopic Hematuria | Full Text | References | PDF (4.4 MB)
  • 33 Views
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Article
Identification of the Different Roles and Potential Mechanisms of T Isoforms in the Tumor Recurrence and Cell Cycle of Chordomas
Junpeng Ma, Wei Chen, Ke Wang, Kaibing Tian, Qi Li, Tianna Zhao, Liwei Zhang, Liang Wang, Zhen Wu & Junting Zhang
Pages: 11777-11791
Published online: 03 Jan 2020
AbstractforIdentification of the Different Roles and Potential Mechanisms of T Isoforms in the Tumor Recurrence and Cell Cycle of Chordomas | Full Text | References | PDF (3.1 MB)
  • 34 Views
  • 7 CrossRef citations
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Review

Review Article
Epstein-Barr Virus-Encoded Products Promote Circulating Tumor Cell Generation: A Novel Mechanism of Nasopharyngeal Carcinoma Metastasis
Zongbei Yang, Jing Wang, Zhenlin Zhang & Faqing Tang
Pages: 11793-11804
Published online: 06 Jan 2020
AbstractforEpstein-Barr Virus-Encoded Products Promote Circulating Tumor Cell Generation: A Novel Mechanism of Nasopharyngeal Carcinoma Metastasis | Full Text | References | PDF (2.3 MB)
  • 43 Views
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Review Article
miRNAs: A Promising Target in the Chemoresistance of Bladder Cancer
Zhonglin Cai, Fa Zhang, Weijie Chen, Jianzhong Zhang & Hongjun Li
Pages: 11805-11816
Published online: 03 Jan 2020
AbstractformiRNAs: A Promising Target in the Chemoresistance of Bladder Cancer | Full Text | References | PDF (3.2 MB)
  • 62 Views
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Original Research

Article
RETRACTED ARTICLE: Circular RNA PVT1 promotes the invasion and epithelial–mesenchymal transition of breast cancer cells through serving as a competing endogenous RNA for miR-204-5p
Qingzhao Bian
Pages: 11817-11826
Published online: 07 Jul 2020
AbstractforRETRACTED ARTICLE: Circular RNA PVT1 promotes the invasion and epithelial–mesenchymal transition of breast cancer cells through serving as a competing endogenous RNA for miR-204-5p | PDF (2.7 MB)
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