Heidelberg Ion Therapy Center (HIT): Initial clinical experience in the first 80 patients

Figures & data

Table I. Patients’ characteristics of the first 80 patients treated at the Heidelberg Ion Therapy center (HIT).

Indication	Number of patients n (%)
Skull Base
Chordoma	9 (11%)
Chondrosarcoma	18 (22%)
Malignant Salivary Gland Tumors	29 (36%)
Astrocytoma	10 (13%)
pilocytic astrocytoma	1
WHO Grade II astrocytoma	2
anaplastic astrocytoma	1
primary glioblastoma	3
recurrent glioblastoma	3
Osteosarcoma	3 (4%)
skull and skull base	2
sacrum	1
Sacral Chordoma	5 (6%)
Other	6 (8%)
recurrent rectal cancer	2
nasopharyngeal cancer	1
rhabdomyosarcoma of the skull base	1
malignant melanoma of the paranasal sinus	1
chondrosarcoma of the left heel	1

Figure 1. a, Carbon ion radiotherapy for recurrent glioblastoma using two horizontal beams. Treatment was performed up to a total dose fo 36 Gy E in 12 fractions ((A) axial, (B) sagittal and (C) coronal view). b, A–D – contrast-enhanced T1-weighted MR-imaging performed for treatment planning prior to carbon ion radiotherapy. E–H – neuroimaging performed 6 weeks after completion of carbon ion radiotherapy with 36 Gy E.

Figure 2. Carbon ion radiotherapy for histologicall confimred sacral chordoma treated with two horizontal beams up to a total dose of 60 Gy E in single fractions of 3 Gy E.

Figure 3. Typical treatment plan for a patient with a skull base chordoma treated up to a total dose of 66 Gy E with carbon ion radiotherapy.

Figure 4. Proton radiotherapy applied with two hirizontal beams for a pediatric low-grade glioma clinically progressive after wait-and-see strategy; a total dose of 54 Gy E protons in single doses of 1.8 Gy E was performed.