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Original Articles

Dynamic contrast-enhanced magnetic resonance imaging of the metastatic potential of tumors: A preclinical study of cervical carcinoma and melanoma xenografts

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Pages 604-611 | Received 03 Dec 2011, Accepted 24 Apr 2012, Published online: 07 Jun 2012

Figures & data

Figure 1. T2-weighted MR-images showing the primary tumor, the draining lymphatic, and the ipsilateral inguinal lymph node of a mouse with a non-metastatic ck-160 tumor (a), a mouse with a metastatic ck-160 tumor (b), and a mouse with a metastatic v-27 tumor (c).

Figure 1. T2-weighted MR-images showing the primary tumor, the draining lymphatic, and the ipsilateral inguinal lymph node of a mouse with a non-metastatic ck-160 tumor (a), a mouse with a metastatic ck-160 tumor (b), and a mouse with a metastatic v-27 tumor (c).

Figure 2. The Ktrans image, Ktrans frequency distribution, ve image, and ve frequency distribution of a non-metastatic ck-160 tumor (a), a metastatic ck-160 tumor (b), a non-metastatic v-27 tumor (c), and a metastatic v-27 tumor (d). Voxels in necrotic tissue have not been excluded from the images and frequency distributions. White scale bars: 3.0 mm.

Figure 2. The Ktrans image, Ktrans frequency distribution, ve image, and ve frequency distribution of a non-metastatic ck-160 tumor (a), a metastatic ck-160 tumor (b), a non-metastatic v-27 tumor (c), and a metastatic v-27 tumor (d). Voxels in necrotic tissue have not been excluded from the images and frequency distributions. White scale bars: 3.0 mm.

Figure 3. Median Ktrans and median ve versus tumor size for ck-160 (a) and v-27 (b) tumors. voxels in necrotic tissue were excluded from the frequency distributions of the v-27 tumors before median values were calculated. points represent single tumors.

Figure 3. Median Ktrans and median ve versus tumor size for ck-160 (a) and v-27 (b) tumors. voxels in necrotic tissue were excluded from the frequency distributions of the v-27 tumors before median values were calculated. points represent single tumors.

Figure 4. Median Ktrans (a), median ve (b), and size (c) of non-metastatic (Neg) and metastatic (Pos) ck-160 tumors. Points represent single tumors. Horizontal bars indicate mean values.

Figure 4. Median Ktrans (a), median ve (b), and size (c) of non-metastatic (Neg) and metastatic (Pos) ck-160 tumors. Points represent single tumors. Horizontal bars indicate mean values.

Figure 5. Necrosis-corrected median Ktrans (a), uncorrected median Ktrans (b), necrosis-corrected median ve (c), uncorrected median ve (d), and size (e) of poorly metastatic (0 or 1 positive lymph node) and highly metastatic (2 or more positive lymph nodes) v-27 tumors. Points represent single tumors. Horizontal bars indicate mean values.

Figure 5. Necrosis-corrected median Ktrans (a), uncorrected median Ktrans (b), necrosis-corrected median ve (c), uncorrected median ve (d), and size (e) of poorly metastatic (0 or 1 positive lymph node) and highly metastatic (2 or more positive lymph nodes) v-27 tumors. Points represent single tumors. Horizontal bars indicate mean values.

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