Prospective evaluation of early treatment outcome in patients with meningiomas treated with particle therapy based on target volume definition with MRI and ⁶⁸Ga-DOTATOC-PET

Figures & data

Table I. Patients’ characteristics of 70 patients treated with proton or carbon ion radiotherapy for benign or high-grade meningiomas.

Characeristic	Number (%)
Gender
male	24 (34)
female	46 (66)
Age
median (range)	49 (21–83)
Histologic classification
no histology	13 (18)
WHO Grade I	30 (43)
WHO Grade II	23 (33)
WHO Grade III	4 (6)
Predominant clinical symptoms
headache	20 (29)
dizziness	17 (24)
nausea	16 (23)
motor deficits	17 (24)
sensory deficits	16 (23)
double vision	17 (24)
visual impairment	21 (30)
other cranial nerve deficits	16 (23)
Time of radiation
Primary radiotherapy	51 (73)
re-irradiation	19 (27)
Radiation modality
protons	38 (54)
carbon ions	17 (24)
photons + carbon ion boost	15 (22)

Figure 1. Imaging for target volume definition for proton radiotherapy of a skull base meningioma treated including CT, MRT and 68-Ga-Dotatoc.

Figure 2. Boost treatment of high-risk meningiomas (A, B) with carbon ions in 6 fractions to a total dose of 18 GyE (MARCIE-Protocol), and photon treatment (C, D) up to 50 GyE in 2 GyE single fractions.

Figure 3. Ratio of volume A/volume B: Statistical difference between large meningiomas infiltrating soft-tissue structures, compared to typical bone-invading meningiomas (p = 0.02).