Rationale and design of the Newer Versus Older Antihypertensive Agents in African Hypertensive Patients (NOAAH) trial

Figures & data

Figure 1. Schematic representation of the trial. HCTZ indicates hydrochlorothiazide.

Table I. Measurements by visit.

Months	−1	−½	0	+½	+1	+2	+3	+4	+5	+6
Visits	S	R1	R2	V½	V1	V2	V3	V4	V5	VT
Blood pressure	x	x	x	x	x	x	x	x	x	x
Tablet count			x	x	x	x	x	x	x	x
Blood sample			x			x				x
Fresh urine sample			x			x				x
Questionnaire			x			x		x		x
Fundoscopy			x							x
ECG			x			x		x		x
PWA and PWV			x			x		x		x

ECG indicates electrocardiogram. PWA and PWV indicate and measurement of pulse wave velocity by means of the SphygmoCor device and software at four centers.

Figure 2. Number of patients screened, enrolled and randomized on December 1, 2010. The dotted line indicates the number of patients to be randomized.

Table II. Average systolic/diastolic blood pressure reductions (mmHg) by 8-week once-daily treatment with different daily doses (mg) of amlodipine and valsartan given alone or in combination.

	Study 1			Study 2
Daily dose amlodipine	0	2.5	5	0	10
Daily dose valsartan
0	7.3/7.1	12.4/9.3	15.1/11.5	12.9/8.6	24.1/15.6
40	11.8/10.1	15.5^ab/10.8	19.6/^ab14.6^ab	…	…
80	12.9/9.7	17.0^ab/13.4^ab	20.8/^ab14.5^ab	…	…
160	15.1/11.0	16.7^b/13.3^ab	19.5/^ab14.2^ab	20.2/13.3^a	27.8^ab/17.6^ab
320	15.7/13.4	18.3^b/14.2^b	22.7^ab/15.9^ab	19.8/13.3^a	28.4^ab/18.6^ab

All differences with placebo (0 mg/day) were statistically significant. ^ap < 0.05 versus the same daily dose of valsartan monotherapy; ^bp < 0.05 versus the same daily dose of amlodipine monotherapy. Adapted with permission from Philipp et al. (80).

Philipp T, Smith TR, Glazer R, Wernsing M, Yen J, Jin J, . Two multicenter, 8-week, randomized, double-blind, placebo-controlled, parallel-group studies evaluating the efficacy and tolerability of amlodipine and valsartan in combination and as monotherapy in adult patients with mild to moderate essential hypertension. Clin Ther. 2007;29:563–580.

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