Antioxidant therapy improves non-thyroidal illness syndrome in uremic rats

Figures & data

Figure 1. The levels of serum MDA (A), SOD (B), AOPP (C), IL-1β (D), FT3 (E), and TSH (F) in each group. Data are given as mean ± SD of four animals per group. #p < 0.05 compared with Blank group. *p < 0.05 compared with 5/6 Nx group.

Table 1. The levels of serum MDA, SOD, AOPP, IL-1β, FT3, and TSH in each group.

Parameters	Blank	5/6Nx	PDTC	SB	NAC	TH
MDA(nmol/mL)	2.11 ± 0.78	6.13 ± 0.37	3.66 ± 0.72	4.70 ± 0.93	4.46 ± 0.94	3.84 ± 0.76
SOD(U/mL)	156.06 ± 8.09	86.24 ± 5.76	129.42 ± 15.72	107.25 ± 17.12	114.40 ± 14.97	124.49 ± 15.67
AOPP(μmol/L)	28.59 ± 1.70	41.39 ± 1.64	35.62 ± 1.54	36.28 ± 1.47	32.15 ± 0.79	38.69 ± 1.68
IL-1β(pg/mL)	88.02 ± 19.04	159.16 ± 42.01	143.16 ± 58.37	109.62 ± 28.43	141.77 ± 69.74	114.61 ± 17.93
FT3 (fmol/mL)	11.27 ± 2.55	6.12 ± 0.27	9.34 ± 0.92	9.51 ± 1.30	10.32 ± 2.59	9.05 ± 1.37
TSH(ng/mL)	0.063 ± 0.017	0.153 ± 0.040	0.073 ± 0.017	0.110 ± 0.037	0.088 ± 0.017	0.070 ± 0.022

Notes: Data are given as mean ± SD of four animals per group. Samples were measured in triplicate.

Figure 2. Effects of PDTC, SB, NAC, and TH treatments on uremic rats by western blot. Normalized densitometric data of IL-1β (A) and DIO1 (B) bands obtained from the protein extractions. RR stands for relative ratio. Values are expressed as fold changes relative to the appropriate controls. Values are given as mean ± SD of four animals per group. #p < 0.05 compared with Blank group. *p < 0.05 compared with 5/6 Nx group.

Figure 3. Effects of PDTC, SB, NAC, and TH treatments on uremic rats by EMSA. Normalized densitometric data of NF-κB band obtained from the extracts of proteins with unclear interaction. Data are given as mean ± SD of 4 animals per group. #p < 0.05 compared with Blank group. *p < 0.05 compared with 5/6 Nx group.