Antioxidant therapy improves non-thyroidal illness syndrome in uremic rats

References

• Chopra IJ. Clinical review 86: Euthyroid sick syndrome: Is it a misnomer? J Clin Endocrinol Metab. 1997;82:329–334.
   PubMed Web of Science ®Google Scholar
• Xu G, Tu W, Qin S. The relationship between deiodinase activity and inflammatory responses under the stimulation of uremic toxins. J Transl Med. 2014;12:239.
   PubMed Web of Science ®Google Scholar
• Dounousi E, Papavasiliou E, Makedou A, et al. Oxidative stress is progressively enhanced with advancing stages of CKD. Am J Kidney Dis. 2006;48:752–760.
   PubMed Web of Science ®Google Scholar
• Xu G, Yan W, Li J. An update for the controversies and hypotheses of regulating nonthyroidal illness syndrome in chronic kidney diseases. Clin Exp Nephrol. 2014;18:837–843.
   PubMed Web of Science ®Google Scholar
• Stenvinkel P. New insights on inflammation in chronic kidney disease-genetic and non-genetic factors. Nephrol Ther. 2006;2:111–119.
   PubMedGoogle Scholar
• Stenvinkel P, Ketteler M, Johnson RJ, et al. IL-10, IL-6, and TNF-alpha: Central factors in the altered cytokine network of uremia - the good, the bad, and the ugly. Kidney Int. 2005;67:1216–1233.
   PubMed Web of Science ®Google Scholar
• Sela S, Shurtz-Swirski R, Cohen-Mazor M, et al. Primed peripheral polymorphonuclear leukocyte: A culprit underlying chronic low-grade inflammation and systemic oxidative stress in chronic kidney disease. J Am Soc Nephrol. 2005;16:2431–2438.
   PubMed Web of Science ®Google Scholar
• Carrero JJ, Qureshi AR, Axelsson J, et al. Clinical and biochemical implications of low thyroid hormone levels (total and free forms) in euthyroid patients with chronic kidney disease. J Intern Med. 2007;262:690–701.
   PubMed Web of Science ®Google Scholar
• Menzies KJ, Robinson BH, Hood DA. Effect of thyroid hormone on mitochondrial properties and oxidative stress in cells from patients with mtDNA defects. Am J Physiol Cell Physiol. 2009;296:C355–C362.
   PubMed Web of Science ®Google Scholar
• Yao YM, Xu CL, Yao FH, Yu Y, Sheng ZY. [The pattern of nuclear factor-kappa B activation in rats with endotoxin shock and its role in biopterin-mediated nitric oxide induction]. Zhonghua Shao Shang Za Zhi. 2006;22:405–410.
   PubMedGoogle Scholar
• Nobel CI, Kimland M, Lind B, Orrenius S, Slater AF. Dithiocarbamates induce apoptosis in thymocytes by raising the intracellular level of redox-active copper. J Biol Chem. 1995;270:26202–26208.
   PubMed Web of Science ®Google Scholar
• Araki S, Dobashi K, Kubo K, Kawagoe R, Yamamoto Y, Shirahata A. N-acetylcysteine inhibits induction of nitric oxide synthase in 3T3-L1 adipocytes. J UOEH. 2007;29:417–429.
   PubMedGoogle Scholar
• Shimizu MH, Coimbra TM, de Araujo M, Menezes LF, Seguro AC. N-acetylcysteine attenuates the progression of chronic renal failure. Kidney Int. 2005;68:2208–2217.
   PubMed Web of Science ®Google Scholar
• Fujihara CK, Antunes GR, Mattar AL, Malheiros DM, Vieira JJ, Zatz R. Chronic inhibition of nuclear factor-kappa B attenuates renal injury in the 5/6 renal ablation model. Am J Physiol Renal Physiol. 2007;292:F92–F99.
   PubMed Web of Science ®Google Scholar
• Fujihara CK, De Nucci G, Zatz R. Chronic nitric oxide synthase inhibition aggravates glomerular injury in rats with subtotal nephrectomy. J Am Soc Nephrol. 1995;5:1498–1507.
   PubMed Web of Science ®Google Scholar
• Zareie M, De Vriese AS, Hekking LH, et al. Immunopathological changes in a uraemic rat model for peritoneal dialysis. Nephrol Dial Transplant. 2005;20:1350–1361.
   PubMed Web of Science ®Google Scholar
• Souma T, Abe M, Moriguchi T, et al. Luminal alkalinization attenuates proteinuria-induced oxidative damage in proximal tubular cells. J Am Soc Nephrol. 2011;22:635–648.
   PubMed Web of Science ®Google Scholar
• Rushworth GF, Megson IL. Existing and potential therapeutic uses for N-acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits. Pharmacol Ther. 2014;141:150–159.
   PubMed Web of Science ®Google Scholar
• Dodd S, Dean O, Copolov DL, Malhi GS, Berk M. N-acetylcysteine for antioxidant therapy: Pharmacology and clinical utility. Expert Opin Biol Ther. 2008;8:1955–1962.
   PubMed Web of Science ®Google Scholar
• Forini F, Lionetti V, Ardehali H, et al. Early long-term L-T3 replacement rescues mitochondria and prevents ischemic cardiac remodelling in rats. J Cell Mol Med. 2011;15:514–524.
   PubMed Web of Science ®Google Scholar
• Pantos C, Mourouzis I, Markakis K, et al. Thyroid hormone attenuates cardiac remodeling and improves hemodynamics early after acute myocardial infarction in rats. Eur J Cardiothorac Surg. 2007;32:333–339.
   PubMed Web of Science ®Google Scholar
• Pantos C, Mourouzis I, Markakis K, Tsagoulis N, Panagiotou M, Cokkinos DV. Long-term thyroid hormone administration reshapes left ventricular chamber and improves cardiac function after myocardial infarction in rats. Basic Res Cardiol. 2008;103:308–318.
   PubMed Web of Science ®Google Scholar
• De Castro AL, Tavares AV, Campos C, et al. Cardioprotective effects of thyroid hormones in a rat model of myocardial infarction are associated with oxidative stress reduction. Mol Cell Endocrinol. 2014;391:22–29.
   PubMed Web of Science ®Google Scholar
• Venditti P, Bari A, Di Stefano L, Di Meo S. Tri-iodothyronine treatment differently affects liver metabolic response and oxidative stress in sedentary and trained rats. J Endocrinol. 2008;197:65–74.
   PubMed Web of Science ®Google Scholar
• Gupta J, Mitra N, Kanetsky PA, et al. Association between albuminuria, kidney function, and inflammatory biomarker profile in CKD in CRIC. Clin J Am Soc Nephrol. 2012;7:1938–1946.
   PubMed Web of Science ®Google Scholar
• Scheidegger KJ, Du J, Delafontaine P. Distinct and common pathways in the regulation of insulin-like growth factor-1 receptor gene expression by angiotensin II and basic fibroblast growth factor. J Biol Chem. 1999;274:3522–3530.
   PubMed Web of Science ®Google Scholar
• Liu SF, Ye X, Malik AB. Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate prevents in vivo expression of proinflammatory genes. Circulation. 1999;100:1330–1337.
   PubMed Web of Science ®Google Scholar
• Schreck R, Meier B, Mannel DN, Droge W, Baeuerle PA. Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells. J Exp Med. 1992;175:1181–1194.
   PubMed Web of Science ®Google Scholar
• Su YW, Chiou WF, Chao SH, Lee MH, Chen CC, Tsai YC. Ligustilide prevents LPS-induced iNOS expression in RAW 264.7 macrophages by preventing ROS production and down-regulating the MAPK, NF-kappaB and AP-1 signaling pathways. Int Immunopharmacol. 2011;11:1166–1172.
   PubMed Web of Science ®Google Scholar
• De Brito-Ashurst I, Varagunam M, Raftery MJ, Yaqoob MM. Bicarbonate supplementation slows progression of CKD and improves nutritional status. J Am Soc Nephrol. 2009;20:2075–2084.
   PubMed Web of Science ®Google Scholar
• Disthabanchong S, Treeruttanawanich A. Oral sodium bicarbonate improves thyroid function in predialysis chronic kidney disease. Am J Nephrol. 2010;32:549–556.
   PubMed Web of Science ®Google Scholar
• Chabicovsky M, Prieschl-Grassauer E, Seipelt J, et al. Pre-clinical safety evaluation of pyrrolidine dithiocarbamate. Basic Clin Pharmacol Toxicol. 2010;107:758–767.
   PubMed Web of Science ®Google Scholar
• Sahraei Z, Salamzadeh J, Nafar M. Effect of N-acetyl cysteine and vitamin C on kidney allograft function biomarkers interleukin-18 and neutrophil gelatinase-associated lipocalin. Iran J Kidney Dis. 2015;9:56–62.
   PubMed Web of Science ®Google Scholar
• Friedman AN, Bostom AG, Laliberty P, Selhub J, Shemin D. The effect of N-acetylcysteine on plasma total homocysteine levels in hemodialysis: A randomized, controlled study. Am J Kidney Dis. 2003;41:442–446.
   PubMed Web of Science ®Google Scholar