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Stress
The International Journal on the Biology of Stress
Volume 14, 2011 - Issue 2
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Original Research Reports

Eugenol as an anti-stress agent: Modulation of hypothalamic–pituitary–adrenal axis and brain monoaminergic systems in a rat model of stress

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Pages 145-155 | Received 23 May 2009, Accepted 02 Aug 2010, Published online: 31 Oct 2010

Figures & data

Figure 1.  Bar diagram representing the RS-induced changes in ulcer index of control, sham, and eugenol-treated [25 mg/kg (E-25), 50 mg/kg (E-50), and 100 mg/kg (E-100)] groups. Results are represented as mean ± SEM with n = 6 in each group. “n” is the number of rats used. *P < 0.05 compared to control, P < 0.05 compared to sham, P < 0.05 compared to E-25, and P < 0.05 compared to E-50 (Student–Newmann–Keuls post hoc test).

Figure 1.  Bar diagram representing the RS-induced changes in ulcer index of control, sham, and eugenol-treated [25 mg/kg (E-25), 50 mg/kg (E-50), and 100 mg/kg (E-100)] groups. Results are represented as mean ± SEM with n = 6 in each group. “n” is the number of rats used. *P < 0.05 compared to control, †P < 0.05 compared to sham, P < 0.05 compared to E-25, and P < 0.05 compared to E-50 (Student–Newmann–Keuls post hoc test).

Figure 2.  Bar diagram representing the RS-induced changes in plasma corticosterone (A) and NE levels (B) of control, sham, and eugenol-treated groups. Results are represented as mean ± SEM with n = 6 in each group. “n” is the number of rats used. *P < 0.05 compared to control, P < 0.05 compared to sham, P < 0.05 compared to E-25, P < 0.05 compared to E-50, and P < 0.05 compared to E-100 (Student–Newmann–Keuls post hoc test).

Figure 2.  Bar diagram representing the RS-induced changes in plasma corticosterone (A) and NE levels (B) of control, sham, and eugenol-treated groups. Results are represented as mean ± SEM with n = 6 in each group. “n” is the number of rats used. *P < 0.05 compared to control, †P < 0.05 compared to sham, ‡P < 0.05 compared to E-25, ¶P < 0.05 compared to E-50, and P < 0.05 compared to E-100 (Student–Newmann–Keuls post hoc test).

Figure 3.  Bar diagram representing the RS-induced changes in the levels of NE (A), 5-HT (B), and 5-HIAA (C) of control, sham, and eugenol treated (50 mg/kg) groups in HIP, HYPO, PFC, and AMY regions of brain. Results are represented as mean ± SEM with n = 6 in each group. “n” is the number of rats used. *P < 0.05 compared to control and P < 0.05 compared to sham group (Student–Newmann–Keuls post hoc test).

Figure 3.  Bar diagram representing the RS-induced changes in the levels of NE (A), 5-HT (B), and 5-HIAA (C) of control, sham, and eugenol treated (50 mg/kg) groups in HIP, HYPO, PFC, and AMY regions of brain. Results are represented as mean ± SEM with n = 6 in each group. “n” is the number of rats used. *P < 0.05 compared to control and †P < 0.05 compared to sham group (Student–Newmann–Keuls post hoc test).

Figure 4.  Bar diagram representing the RS-induced changes in the levels of DA (A), DOPAC (B), and HVA (C) of control, sham, and eugenol treated (50 mg/kg) groups in HIP, HYPO, PFC, and AMY regions of brain. Results are represented as mean ± SEM with n = 6 in each group. “n” is the number of rats used. *P < 0.05 compared to control and P < 0.05 compared to sham group (Student–Newmann–Keuls post hoc test).

Figure 4.  Bar diagram representing the RS-induced changes in the levels of DA (A), DOPAC (B), and HVA (C) of control, sham, and eugenol treated (50 mg/kg) groups in HIP, HYPO, PFC, and AMY regions of brain. Results are represented as mean ± SEM with n = 6 in each group. “n” is the number of rats used. *P < 0.05 compared to control and †P < 0.05 compared to sham group (Student–Newmann–Keuls post hoc test).

Figure 5.  Bar diagram representing the RS-induced changes in the metabolite/monoamine ratios, DOPAC/DA (A), HVA/DA (B), and 5-HIAA/5-HT (C) of control, sham, and eugenol-treated (50 mg/kg) groups in HIP, HYPO, PFC, and AMY regions of brain. Results are represented as mean ± SEM with n = 6 in each group. “n” is the number of rats used. *P < 0.05 compared to control and P < 0.05 compared to sham group (Student–Newmann–Keuls post hoc test).

Figure 5.  Bar diagram representing the RS-induced changes in the metabolite/monoamine ratios, DOPAC/DA (A), HVA/DA (B), and 5-HIAA/5-HT (C) of control, sham, and eugenol-treated (50 mg/kg) groups in HIP, HYPO, PFC, and AMY regions of brain. Results are represented as mean ± SEM with n = 6 in each group. “n” is the number of rats used. *P < 0.05 compared to control and †P < 0.05 compared to sham group (Student–Newmann–Keuls post hoc test).

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