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Research Article

Curcumin-loaded lipid nanocarrier for improving bioavailability, stability and cytotoxicity against malignant glioma cells

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Pages 214-229 | Received 01 Feb 2014, Accepted 26 Mar 2014, Published online: 14 May 2014

Figures & data

Figure 1. (a) Solubility of curcumin in different oils; (b) Solubility of curcumin in surfactants.

Figure 1. (a) Solubility of curcumin in different oils; (b) Solubility of curcumin in surfactants.

Figure 2. Pseudoternary phase diagram for optimization of NE.

Figure 2. Pseudoternary phase diagram for optimization of NE.

Table 1. NE formulations composition, physical stability and dispersion studies.

Figure 3. (a) The globule size distribution of NE-SB1; (b) Surface morphology of NE-SB1by TEM; (c) Surface topography of NE-SB1 by AFM.

Figure 3. (a) The globule size distribution of NE-SB1; (b) Surface morphology of NE-SB1by TEM; (c) Surface topography of NE-SB1 by AFM.

Table 2. Parameters of selected NE formulations.

Figure 4. (a) Ex vivo release profile of CU in phosphate buffer (pH 6.8); (b) % FFA release profile with time.

Figure 4. (a) Ex vivo release profile of CU in phosphate buffer (pH 6.8); (b) % FFA release profile with time.

Figure 5. Plasma concentration-time profile of curcumin after oral administration of NE-SB1 (50 mg/kg) to rats. Each data point represents the mean ± S.D. of three determinations.

Figure 5. Plasma concentration-time profile of curcumin after oral administration of NE-SB1 (50 mg/kg) to rats. Each data point represents the mean ± S.D. of three determinations.

Table 3. Pharmacokinetic parameters after oral administration of CU formulations to rats.

Figure 6. Anti-proliferative activity study of CU solution and NE-SB1 formulation.

Figure 6. Anti-proliferative activity study of CU solution and NE-SB1 formulation.

Table 4. Accelerated stability studies observation of NE-SB1 formulation.

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