The human heart releases cardiotrophin-1after coronary artery bypass grafting with cardiopulmonary bypass

Figures & data

Table I. Clinical data.

Parameter	Data
Age (years)	68.8 ± 5.9
Gender (male/female)	20/4
Body weight (kg)	79.8 ± 11.6
Ejection fraction (%)	57.3 ± 16.0
NYHA (II/III/IV)	6/13/5
No. of grafts	3.3 ± 0.9
Cardiopulmonary bypass time (min)	88.7 ± 26.3
Aortic cross-clamping time (min)	69.6 ± 22.3
Creatine kinase -MB (U/L)
baseline	5.3 ± 2.6
6 hours	19.6 ± 8.7^*
12 hours	18.0 ± 11.7^*
24 hours	21.2 ± 15.8^*
24-hour bleeding (ml)	795.8 ± 411.6
Ventilation time (hours)	15.2 ± 3.8

NYHA, New York Heart Association. Data are presented as mean ± standard deviation, or numbers. *p < 0.001, as compared to baseline.

Table II. Hemodynamic parameters.

Measurement	Baseline	1 h after CPB	6 h after CPB	12 h after CPB	24 h after CPB
HR (beats/min)	57.1 ± 7.8	75.4 ± 21.7	79.3 ± 15.7	86.9 ± 13.6	80.8 ± 9.7
MAP (mmHg)	81.7 ± 18.0	68.9 ± 10.8	69.8 ± 7.5	72.5 ± 10.2	76.6 ± 11.0
MPAP (mmHg)	18.9 ± 4.5	20.7 ± 3.9	21.2 ± 3.0	20.7 ± 4.1	19.4 ± 3.7
PCWP (mmHg)	12.2 ± 4.9	12.2 ± 3.4	10.6 ± 2.6	10.6 ± 2.6	10.8 ± 3.2
CVP (mmHg)	7.0 ± 2.7	9.9 ± 2.5	9.2 ± 2.0	8.3 ± 3.3	9.1 ± 6.8
CI (L/min/m^2)	2.7 ± 0.5	2.9 ± 0.5	3.1 ± 0.7	3.5 ± 0.9	3.3 ± 0.7
SVRI (dyn.s/cm^3/m^2)	2259.2 ± 604.1	1723.2 ± 454.6	1647.7 ± 430.8	1550.0 ± 523.5	1733.6 ± 515.2

HR, heart rate; MAP, mean artery pressure; MPAP, mean pulmonary artery pressure; PCWP, pulmonary capillary wedge pressure; CVP, central venous pressure; CI, cardiac index; SVRI, systemic vascular resistance index. Data are presented as mean ± standard deviation.

Figure 1. Perioperative arterial CT-1 levels. CT-1 levels were measured before CPB, 5 min and 20 minutes after reperfusion, 1 h, 6 h, 12 h, 24 h after CPB.

Figure 2. CT-1 levels from radial artery and coronary sinus. *p < 0.05, as compared to CT-1 level from radial artery.