Figures & data
Figure 1. AChE reactivators. Pralidoxime (2-PAM) as a representative of reactivators with one pyridinium ring and HI-6 as the most typical bisquaternary oxime.
Figure 2. Detail of 2GYU active site with the most important residues participating in reactivator binding displayed. The reactivator (HI-6) itself and the catalytic Ser203 are highlighted with bolder tubes.
Figure 3. Sequence alignment of BuChE (1P0I) and AChE (2GYU, chain A). The important residues influencing reactivator binding are marked by arrows. The alignment score is represented illustratively by symbols (star, colon, full stop, space) above the alignment rows. The far right column shows the number of the last residue in a row.
Figure 4. Aligned protein backbones of BuChE (1P0I) and AChE (2GYU) in rainbow colors and black, respectively.
Figure 5. 3-D alignment of BuChE (1P0I) and AChE (2GYU). Only the BuChE backbone is displayed and only residues influencing reactivator binding and catalytic Ser203 are shown. The relevant BuChE residues are highlighted by bolder tubes. Labels follow a pattern: BuChE residue/AChE residue.
