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Research Article

Anti-hyperglycaemic effects of the Japanese red maple Acer pycnanthum and its constituents the ginnalins B and C

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Pages 176-180 | Received 07 Jan 2010, Accepted 15 Apr 2010, Published online: 21 Jun 2010

Figures & data

Figure 1.  Anti-hyperglycaemic effects of APM in mice. Fasted mice were given 2,000 mg/kg of sucrose (A), 1,000 mg/kg of glucose (B), with or without 100 mg/kg of APM (methanol extract of Acer pycnanthum: open squares), 3 mg/kg of acarbose (closed triangles) and vehicle (control: closed squares), Data are presented as the mean ± S.E. (n = 6). ***; p <0.005, *; p <0.05 versus the control.

Figure 1.  Anti-hyperglycaemic effects of APM in mice. Fasted mice were given 2,000 mg/kg of sucrose (A), 1,000 mg/kg of glucose (B), with or without 100 mg/kg of APM (methanol extract of Acer pycnanthum: open squares), 3 mg/kg of acarbose (closed triangles) and vehicle (control: closed squares), Data are presented as the mean ± S.E. (n = 6). ***; p <0.005, *; p <0.05 versus the control.

Figure 2.  Chemical structures of ginnalins B and C.

Figure 2.  Chemical structures of ginnalins B and C.

Figure 3.  Kinetics analysis of sucrase inhibition by ginnalins B and C. Linewever-Burk plots for inhibitory activity of ginnalin B (A) and C (B) on intestinal sucrase.

Figure 3.  Kinetics analysis of sucrase inhibition by ginnalins B and C. Linewever-Burk plots for inhibitory activity of ginnalin B (A) and C (B) on intestinal sucrase.

Figure 4.  Anti-hyperglycaemic effects of ginnalins B and C in sucrose-loaded mice. Fasted mice were given 2,000 mg/kg of sucrose with 24 mg/ kg of ginnalin B (open squares) or 24 mg/kg of ginnalin C (closed triangles) and vehicle (control: closed squares). Data are presented as the mean ± S.E. (n = 8). ***; p <0.005 versus the control.

Figure 4.  Anti-hyperglycaemic effects of ginnalins B and C in sucrose-loaded mice. Fasted mice were given 2,000 mg/kg of sucrose with 24 mg/ kg of ginnalin B (open squares) or 24 mg/kg of ginnalin C (closed triangles) and vehicle (control: closed squares). Data are presented as the mean ± S.E. (n = 8). ***; p <0.005 versus the control.

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