Synthesis and biological evaluation of some novel sulfamoylphenyl-pyridazinone as anti-inflammatory agents (Part-II)

Figures & data

Scheme 1.  Reagents and conditions: EtOH, reflux 18–24 h.

Table 1.  Effect of pyridazinone derivatives on carrageenan induced hind paw edema in rats.

Treatment	Dose per kg b.w.	Increase in paw volume (mL ± SEM) after carrageenan administration
		3 h	5 h
Vehicle	10 ml/kg	0.38 ± 0.0307	0.42 ± 0.0401
Celecoxib	20 mg	0.066 ± 0.0210* (82.6%)	0.06 ± 0.02* (85.7%)
2a	20 mg	0.2 ± 0.000* (47.4%)	0.13 ± 0.0210* (69%)
2b	20 mg	0.15 ± 0.02236* (60.5%)	0.05 ± 0.03416* (88.1%)
2c	20 mg	0.28 ± 0.01667* (23.3%)	0.2 ± 0.0258* (52.4%)
2d	20 mg	0.08 ± 0.01667* (78.9%)	0.08 ± 0.01667* (81%)
2e	20 mg	0.23 ± 0.0333* (39.4%)	0.13 ± 0.0333* (69%)
2f	20 mg	0.2 ± 0.02582* (47.3%)	0.12 ± 0.03073* (71.4%)
2g	20 mg	0.1 ± 0.02582* (73.6%)	0.08 ± 0.03073* (80.9%)

*P < 0.05 compared to control (one-way analysis of variance followed by Dunnett’s test). Values are presented as mean ± S.E.M. (n = 6). Values in parentheses represent percent inhibitions.