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Research Article

Effects of cysteinyl-leukotriene receptors’ antagonism by montelukast on lung mechanics and olfactory system histology in healthy mice

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Pages 521-527 | Received 19 May 2011, Accepted 15 Jun 2011, Published online: 10 Aug 2011

Figures & data

Figure 1.  Representative tracings of the lateral tracheal pressure upon flow interruption during constant-flow inflation. The relevant pressures used for calculation of lung mechanics are indicated: the maximal pressure at the end of inflation (Pdyn,max), the pressure immediately after flow interruption (P1), the static elastic pressure of the lung (Pel,l), the pressure drop due to the ohmic lung resistance (Pmin,l) and total pressure drop which includes the effects of stress relaxation (Pmax,l).

Figure 1.  Representative tracings of the lateral tracheal pressure upon flow interruption during constant-flow inflation. The relevant pressures used for calculation of lung mechanics are indicated: the maximal pressure at the end of inflation (Pdyn,max), the pressure immediately after flow interruption (P1), the static elastic pressure of the lung (Pel,l), the pressure drop due to the ohmic lung resistance (Pmin,l) and total pressure drop which includes the effects of stress relaxation (Pmax,l).

Figure 2.  Mean values (vertical bars represent one SE, n = 11) of static lung elastance (Est,l) in control and montelukast-treated mice are not significantly different.

Figure 2.  Mean values (vertical bars represent one SE, n = 11) of static lung elastance (Est,l) in control and montelukast-treated mice are not significantly different.

Figure 3.  Mean values (vertical bars represent one SE, n = 11) of (a) total (Rmax,l), (b) ohmic airway (Rmin,l) and (c) visco-elastic resistances (Rvisc,l) in control and montelukast-treated mice are not significantly different.

Figure 3.  Mean values (vertical bars represent one SE, n = 11) of (a) total (Rmax,l), (b) ohmic airway (Rmin,l) and (c) visco-elastic resistances (Rvisc,l) in control and montelukast-treated mice are not significantly different.

Figure 4.  Mean values (vertical bars represent one SE, n = 11) of lung hysteresis (Hy,l) in control and montelukast-treated mice are significantly different. *: p < 0.05.

Figure 4.  Mean values (vertical bars represent one SE, n = 11) of lung hysteresis (Hy,l) in control and montelukast-treated mice are significantly different. *: p < 0.05.

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