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Short Communications

Antiproliferative activity of some 1,4-dimethylcarbazoles on cells that express estrogen receptors: part I

, , , , , , , , & show all
Pages 609-613 | Received 09 Jun 2011, Accepted 29 Jun 2011, Published online: 02 Sep 2011

Figures & data

Figure 1.  Carbazole derivatives (1a–g).

Figure 1.  Carbazole derivatives (1a–g).

Figure 2.  Effect of carbazole derivatives (1a–e) against MCF-7 and ISK cell proliferation. MCF-7 (A) and ISK (B) cells were treated for 96 or 24 h, respectively, after 24-h starvation, with the indicated concentrations of substances 1a, 1b, 1c, 1d and 1e. Cells proliferation was evaluated by MTT assay. Statistically significant differences are indicated. Histograms; mean of three independent experiments each performed with triplicate samples expressed as percent of basal; bars, SE (*P < 0.01 compared with basal).

Figure 2.  Effect of carbazole derivatives (1a–e) against MCF-7 and ISK cell proliferation. MCF-7 (A) and ISK (B) cells were treated for 96 or 24 h, respectively, after 24-h starvation, with the indicated concentrations of substances 1a, 1b, 1c, 1d and 1e. Cells proliferation was evaluated by MTT assay. Statistically significant differences are indicated. Histograms; mean of three independent experiments each performed with triplicate samples expressed as percent of basal; bars, SE (*P < 0.01 compared with basal).

Figure 3.  Effect of carbazole derivatives (1f–g) against MCF-7 and ISK cell proliferation. MCF-7 (A) and ISK (B) cells were treated for 96 or 24 h, respectively, after 24-h starvation, with the indicated concentrations of substances 1f and 1g. Cells proliferation was evaluated by MTT assay. Statistically significant differences are indicated. Histograms; mean of three independent experiments each performed with triplicate samples expressed as percent of basal; bars, SE (*P < 0.01 compared with basal).

Figure 3.  Effect of carbazole derivatives (1f–g) against MCF-7 and ISK cell proliferation. MCF-7 (A) and ISK (B) cells were treated for 96 or 24 h, respectively, after 24-h starvation, with the indicated concentrations of substances 1f and 1g. Cells proliferation was evaluated by MTT assay. Statistically significant differences are indicated. Histograms; mean of three independent experiments each performed with triplicate samples expressed as percent of basal; bars, SE (*P < 0.01 compared with basal).

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