Synthesis, characterization and antimicrobial activity of novel xanthene sulfonamide and carboxamide derivatives

Figures & data

Scheme 1.  Biologically active xanthenes.

Scheme 2.  Synthesis of xanthene sulfonamides 6a–n and xanthene carboxamides 8a–h.

Table 1.  Inhibition zones of compounds against to the test microorganisms.

Compounds	Candida albicans	Candida glabrata	Salmonella enteritidis	Staphylococcus aureus	Escherichia coli ATCC	Bacillus subtilis
3a	+	+	++	–	+	−
3b	+	+	+	++	++	++
4a	+	+	+	++	+	++
4b	+	++	++	++	+	+
6a	+	+	++	++	++	−
6b	+	+	++	++	++	−
6c	-	++	+++	++	++	−
6d	+	++	++	++	++	−
6e	+	+	++	++	++	−
6f	+	++	++	++	++	++
6g	+	+	+	++	++	−
6h	+	++	++	+	++	−
6i	+	++	++	++	++	−
6j	+	++	++	++	++	−
6k	+	+	++	++	++	−
6l	+	+	++	++	++	−
6m	+	++	++	+++	++	++
6n	+	++	++	++	++	+
8a	+	++	++	++	++	−
8b	+	++	++	+++	++	−
8c	+	++	++	++	++	−
8d	+	−	++	++	+	−
8e	+	++	++	++	++	−
8f	−	++	++	++	++	−
8g	+	+	++	++	++	+
8h	+	+	++	++	+	+
Erythromycin	−	−	++	+++	++	++++
Nystatin	+++	+++	−	−	−	−

+, inhibition values 1–10 mm between control; ++, inhibition values 10–20 mm between control; +++, inhibition values 20–30 mm between control; ++++, inhibition values 30–40 mm between control; -, not detected.