Synthesis and antileishmanial activity of novel pyridinium-hydrazone derivatives

Figures & data

Scheme 1.  The synthesis pathway and the structures of the compounds. (a) substituted acetophenon, C₂H₅OH, reflux and (b) RX, C₂H₅OH, reflux.

Table 1.  Structures and in vitro antileishmanial activities of compounds (2a–5d).

Compound	IC50^a (µM) L. tropica
2a	44.25
2b	30.50
2c	43.82
2d	45.69
3a	106.36
3b	11.69
3c	12.03
3d	6.90
4a	40.78
4b	27.89
4c	22.98
4d	47.30
5a	40.32
5b	82.61
5c	9.92
5d	60.23
Meglumine antimonate (glucantime)	20.49
DMSO	–
Control	–

^aIC₅₀ values were calculated according to a parametric statistical procedure (Finney Probit Analysis Programme)⁴⁸ with the associated 95% confidence interval.

Finney DG. (1971). Probit analysis. 3rd ed. London: Cambridge University Press.

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