Synthesis of 3-aroyl-4-aryl-1-isopropylamino-4-piperidinols and evaluation of the cytotoxicities of the compounds against human hepatoma and breast cancer cell lines

Figures & data

Figure 1. 3-Aroyl-4-aryl-1-isopropylamino-4-piperidinols type compounds synthesized, 2a–2g and 3.

Scheme 1. The synthesis of 3-aroyl-4-aryl-1-isopropylamino-4-piperidinols, 2a–2g and 3.

Table 1. Cytotoxic activities against Huh7 cells and T47D cells of the compounds synthesized.

Compounds	Ar	Cytotoxicity (IC50) (µM)	Cytotoxicity (IC50) (µM)
		Huh7	T47D
2a	C6H5	13.8	13.9
2b	4-CH3C6H4	136.6	66.9
2c	4-CH3OC6H4	11.1	11.6
2d	4-ClC6H4	48.9	47.4
2e	4-FC6H4	45.9	29.5
2f	4-BrC6H4	9.1	9.3
2g	4-NO2C6H4	32.3	28.3
3	C4H3S(2-yl)	13.3	12.8
	5FU	42.2	7.00