Views

CrossRef citations to date

Altmetric

Research Article

Design, synthesis and biological evaluation of 4-benzoyl-1-dichlorobenzoylthiosemicarbazides as potent Gram-positive antibacterial agents

Agata PanethDepartment of Organic Chemistry and Correspondence[email protected]

Tomasz PlechDepartment of Organic Chemistry and Correspondence[email protected]

Barbara KaprońDepartment of Organic Chemistry and

Dominika HagelDepartment of Organic Chemistry and

Urszula KosikowskaDepartment of Pharmaceutical Microbiology, Medical University of Lublin, Lublin, Poland,

Edyta KuśmierzDepartment of Organic Chemistry and

Katarzyna DzitkoDepartment of Immunoparasitology, University of Łódź, Łódź, Poland, and

Piotr PanethInstitute of Applied Radiation Chemistry, Lodz University of Technology, Lodz, Poland

show all

Figures & data

Figure 1. Synthetic route for preparation of 4-benzoyl-1-dichlorobenzoylthiosemicarbazides 1–12. R¹ and R² substituents are presented in .

Figure 1. Synthetic route for preparation of 4-benzoyl-1-dichlorobenzoylthiosemicarbazides 1–12. R1 and R2 substituents are presented in Table 1.

**Table 1. In vitro antibacterial screening of compounds 1–12 against panel of reference strains.**

Download CSV Display Table

**Table 2. Metabolic activity of mouse L929 and human HeLa cell lines*.**

Download CSV Display Table

**Table 3. In vitro antibacterial screening of 3 and 11 against clinical isolates S. aureus.**

Download CSV Display Table

**Table 4. In vitro effects of 3 and 11 on planktonic cells and biofilms formation in clinical isolates of S. aureus and H. parainfluenzae.**

Download CSV Display Table

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Design, synthesis and biological evaluation of 4-benzoyl-1-dichlorobenzoylthiosemicarbazides as potent Gram-positive antibacterial agents

**Table 1. In vitro antibacterial screening of compounds 1–12 against panel of reference strains.**

**Table 2. Metabolic activity of mouse L929 and human HeLa cell lines*.**

**Table 3. In vitro antibacterial screening of 3 and 11 against clinical isolates S. aureus.**

**Table 4. In vitro effects of 3 and 11 on planktonic cells and biofilms formation in clinical isolates of S. aureus and H. parainfluenzae.**

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Design, synthesis and biological evaluation of 4-benzoyl-1-dichlorobenzoylthiosemicarbazides as potent Gram-positive antibacterial agents

Figures & data

Table 1. In vitro antibacterial screening of compounds 1–12 against panel of reference strains.

Table 2. Metabolic activity of mouse L929 and human HeLa cell lines*.

Table 3. In vitro antibacterial screening of 3 and 11 against clinical isolates S. aureus.

Table 4. In vitro effects of 3 and 11 on planktonic cells and biofilms formation in clinical isolates of S. aureus and H. parainfluenzae.

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

**Table 1. In vitro antibacterial screening of compounds 1–12 against panel of reference strains.**

**Table 2. Metabolic activity of mouse L929 and human HeLa cell lines*.**

**Table 3. In vitro antibacterial screening of 3 and 11 against clinical isolates S. aureus.**

**Table 4. In vitro effects of 3 and 11 on planktonic cells and biofilms formation in clinical isolates of S. aureus and H. parainfluenzae.**