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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 31, 2016 - Issue 3
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Research Article

Docking study: PPARs interaction with the selected alternative plasticizers to di(2-ethylhexyl) phthalate

Nicolas KambiaDepartment of Pharmacology and Clinical Pharmacy, EA GRITA and Correspondence[email protected]
,
Amaury FarceDepartment of Therapeutic Chemistry, Faculty of Pharmaceutical and Biological Sciences, Université de Lille, Lille, France
,
Karim BelarbiDepartment of Pharmacology and Clinical Pharmacy, EA GRITA and
,
Bernard GressierDepartment of Pharmacology and Clinical Pharmacy, EA GRITA and
,
Michel LuyckxDepartment of Pharmacology and Clinical Pharmacy, EA GRITA and
,
Philippe ChavatteDepartment of Therapeutic Chemistry, Faculty of Pharmaceutical and Biological Sciences, Université de Lille, Lille, France
&
Thierry DineDepartment of Pharmacology and Clinical Pharmacy, EA GRITA and
show all
Pages 448-455 | Received 19 Dec 2014, Accepted 15 Mar 2015, Published online: 05 May 2015

Figures & data

Figure 1. Chemical structures of di(2-ethylhexyl) phthalate (DEHP) and the selected alternative plasticizers investigated.

Figure 1. Chemical structures of di(2-ethylhexyl) phthalate (DEHP) and the selected alternative plasticizers investigated.

Figure 2. Docking of DEHP in PPARα (left panel) and γ (right panel).

Figure 2. Docking of DEHP in PPARα (left panel) and γ (right panel).

Figure 3. Docking of DEHT in PPARα (upper panel) and γ (lower panel).

Figure 3. Docking of DEHT in PPARα (upper panel) and γ (lower panel).

Figure 4. Docking of DEHA in PPARα (left panel) and γ (right panel).

Figure 4. Docking of DEHA in PPARα (left panel) and γ (right panel).

Figure 5. Docking of DINP in PPARα (left panel) and γ (right panel).

Figure 5. Docking of DINP in PPARα (left panel) and γ (right panel).

Figure 6. Docking of cis DINCH in PPARα (upper panel) and γ (lower panel).

Figure 6. Docking of cis DINCH in PPARα (upper panel) and γ (lower panel).

Figure 7. Docking of trans DINCH in PPARα (left panel) and γ (right panel).

Figure 7. Docking of trans DINCH in PPARα (left panel) and γ (right panel).

Figure 8. Docking of ATBC in PPARα (left panel) and γ (right panel).

Figure 8. Docking of ATBC in PPARα (left panel) and γ (right panel).

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