In vitro inhibition effect of some coumarin compounds on purified human serum paraoxonase 1 (PON1)

Figures & data

Figure 1. Prepared compounds by literature19^,20.

Table 1. The IC₅₀ values of coumarin derivatives on purified PON1 activity.

Compound No.	IC50 (µM)	Compound No.	IC50 (µM)
1	287	11	104
2	88	12	100
3	133	13	34
4	94	14	84
5	95	15	90
6	35	16	42
7	87	17	42
8	68	18	84
9	340	19	88
10	192	20	143

Karatas MO, Alici B, Cakir U, et al. Synthesis and carbonic anhydrase inhibitory properties of novel coumarin derivatives. J Enzyme Inhib Med Chem 2012;28:299–304

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Karatas MO, Alici B, Cakir U, et al. New coumarin derivatives as carbonic anhydrase inhibitors. Artif Cells Nanomed Biotechnol 2014;42:192–8

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