Figures & data
Figure 1. Pictorial view of the Bacillus stearothermophilus Alr homodimer (PBD ID: 1SFT). PLP (pyridoxyl 5′-phosphate), ACT (acetate), Lys (lysine).
Figure 2. Structure of Alr inhibitor O-carbamyl-d-serine 1.
Figure 3. Structures of Alr inhibitor d-cycloserine 2 and l-cycloserine 3.
Figure 4. Enantiomers of β-chloroalanine as Alr inhibitor 4 and 5.
Figure 5. Structures of d,l-cycloserine analogs 6 as Alr inhibitors.
Figure 6. Structure of alafosfalin 7.
Figure 7. Derivatives of alafosfalin 8a–e as Alr inhibitors.
Figure 8. Aminomethylphosphonopeptide analogs 9 as Alr inhibitors.
Figure 9. Structures of 1-aminoethylphosphonic acid enantiomers 10a–g and 11 as Alr inhibitors.
Figure 10. Structures of β-d-fluoroalanine 12, β-l-fluoroalanine 13 and O-acetyl-d-serine 14 as Alr inhibitors.
Figure 11. Structures of fluorinated 1-aminoethyl phosphonic acid analogs 15–17 as Alr inhibitors.
Figure 12. Structures of (β-chloro-α-aminoethyl)phosphonic acid derivatives 18–20 as Alr inhibitors.
Figure 13. Structure of dl-(1-amino-2-propeny1)phosphonic acid 21 as an Alr inhibitor.
Figure 14. Structure of 1-aminocyclopropanephosphonate 22 as an Alr inhibitor.
Figure 15. Structure of halovinylglycines 23 as Alr inhibitors.
Figure 16. Structure of l-norvalyl-l-chlorovinylglycine 24 as an Alr inhibitor.
Figure 17. Structures of peptidyl and amino acid C10-esters of deacetylcephalothin 25–29 as Alr inhibitors.
Figure 18. Structure of (1-aminoethy1)boronic acid (Ala-B) 30 as an Alr inhibitor.
Figure 19. Structure of Alr inhibitor β,β,β-trifluoro alanine 31.
Figure 20. Structures of non-substrate Alr inhibitors 32–39.
Figure 21. Structure of thiadiazolidinones 40 and 41a–k as Alr inhibitors.
