Therapeutic approaches to age-associated neurocognitive disorders

Aproximaciones terapéuticas a los trastornos neurocognitivos asociados con la edad

Approches thérapeutiques des troubles neurocognitifs liés à l'âge

Ruth O'Haraa Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University, Stanford, Calif, USACorrespondence[email protected]

Christian Derouesnéb Department of Neurology, Groupe Hospitalier PitieSalpetriere, Paris, France

Konstantinos N. Fountoulakisc Department of Psychiatry, Aristotle University of Thessaloniki, Thessaloniki, Greece

Jerome A. Yesavaged Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University, Stanford, Calif, USA; VA Palo Alto Health Care System, Palo Alto, Calif, USA

Figures & data

Figure 1. Potential physiological pathways to Alzheimer's disease. APOE, apolipoprotein E; CSF, cerebrospinal fluid; PET, positron emission tomography; fMRI, functional magnetic resonance imaging. Reproduced from reference 8: Sunderland T. Alzheimer's disease. Cholinergic therapy and beyond. Am J Geriatr Psychiatry. 1998;6(suppl 1):S56-S63. Copyright © 1998, American Association for Geriatric Psychiatre.

Figure 2. Typical clinical course: current and future therapeutic approaches. AACD, ageassociated cognitive decline; AD, Alzheimer's disease; MCI, mild cognitive impairment. Reproduced from reference 8: Sunderland T. Alzheimer's disease. Cholinergic therapy and beyond. Am J Geriatr Psychiatry. 1998;6(suppl 1):S56-S63. Copyright © 1998, American Association for Geriatric Psychiatry.

Table I. Prevalence of dementia.

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Table II. Pathophysiological mechanisms of Alzheimer's disease and associated therapeutic approaches. HMG-CoA, 3-hydroxy-3-methylglutaryl coenzyme A.

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Therapeutic approaches to age-associated neurocognitive disorders

Aproximaciones terapéuticas a los trastornos neurocognitivos asociados con la edad

Approches thérapeutiques des troubles neurocognitifs liés à l'âge

Table I. Prevalence of dementia.

Table II. Pathophysiological mechanisms of Alzheimer's disease and associated therapeutic approaches. HMG-CoA, 3-hydroxy-3-methylglutaryl coenzyme A.

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Therapeutic approaches to age-associated neurocognitive disorders

Aproximaciones terapéuticas a los trastornos neurocognitivos asociados con la edad

Approches thérapeutiques des troubles neurocognitifs liés à l'âge

Figures & data

Table I. Prevalence of dementia.

Table II. Pathophysiological mechanisms of Alzheimer's disease and associated therapeutic approaches. HMG-CoA, 3-hydroxy-3-methylglutaryl coenzyme A.

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