REFERENCES

• United Nations.World Population Prospects: The 1996 Revision. Population division of the Department of Economie and Social Affairs of the United Nations Secretariat: Washington, DC;1996
   Google Scholar
• KatzmanR.FoxP.The World-Wide Impact of Dementia. Projections of Prevalence and Costs. In: Mayeaux R, Christen Y, eds.Epidemiology of Alzheimer's Disease: From Gene to Prevention. Berlin, Germany: Springer-Verlag;1999117
   Google Scholar
• ParkDC.Applied cognitive aging research. In: Craik FIM, Salthouse TA, eds.The Handbook of Aging and Cognition. Hillsdale, NJ: Lawrence Erlbaum;1992449493
   Google Scholar
• GrassleyC.Preparing for the baby boomer's retirement: the role of employment. Chairman of the Forum. US Senate Special Committee on Aging; 1997
   Google Scholar
• JacksonWA.The Political Economy of Population Ageing. Northampton, Mass: Edward Elgar;1998
   Google Scholar
• PetersenRC.SmithGE.WaringSC.et al.Mild cognitive impairment: clinical characterization and outcome.Arch Neurol.19995630330810190820
   PubMed Web of Science ®Google Scholar
• O'HaraR.YesavageJA.KraemerHC.et al.The APOE ε4 allele is associated with decline on delayed recall performance in community-dwelling older adults.J Am Geriatr Soc.199846
   PubMed Web of Science ®Google Scholar
• SunderlandT.Alzheimer's disease. Cholinergic therapy and beyond.Am J Geriatr Psychiatry.19986(suppl 1)S56S639581222
   PubMed Web of Science ®Google Scholar
• TsolakiM.FountoulakisKN.PavlopoulosI.ChantziE.KazisA.Prevalence and incidence of Alzheimer's disease and other dementing disorders in Pylea, Greece.Am J Alzheimer Dis.199914138149
   Google Scholar
• CummingsJ.Cognitive and behavioral heterogeneity in Alzheimer's disease: seeking the neurobiological basis.Neurobiol Aging.20002184586111124429
   PubMed Web of Science ®Google Scholar
• BrookmeyerR.GrayS.KawasC.Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset.Am J Public Health.199888133713429736873
   PubMed Web of Science ®Google Scholar
• PraticoD.DelantyN.Oxidative injury in diseases of the central nervous system: focus on Alzheimer's disease.Am J Med.200010957758511063960
   PubMed Web of Science ®Google Scholar
• EverittBJ.RobbinsTW.Central cholinergic systems and cognition.Annu Rev Psychol.1997486496849046571
   PubMed Web of Science ®Google Scholar
• PerryEK.TomlinsonBE.BlessedG.et al.Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.BMJ.1978214571459719462
   PubMed Web of Science ®Google Scholar
• BowenDM.SmithCB.WhiteP.DavisonAN.Neurotransmltter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies.Brain.19769945949611871
   PubMed Web of Science ®Google Scholar
• DaviesP.MaloneyA.Selective loss of central cholinergic neurons in Alzheimer's disease.Lancet.19762140363862
   PubMed Web of Science ®Google Scholar
• PerryEK.GibsonPH.BlessedG.PerryRH.TomlinsonBE.Neurotransmitter enzyme abnormalities in senile dementia. Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue.J Neurol Sci.197734247265144789
   PubMed Web of Science ®Google Scholar
• NilssonL.NordbergA.HardyJ.WesterP.WinbladB.Physostigmine restores 3H-acetylcholine efflux from Alzheimer brain slices to normal level.J Neural Transm.1986672752853806081
   PubMed Web of Science ®Google Scholar
• RylettRJ.BallMJ.ColhounEH.Evidence for high affinity choline transport in synaptosomes prepared from hippocampus and neocortex of patients with Alzheimer's disease.Brain Res.19832891691756661641
   PubMed Web of Science ®Google Scholar
• WhitehousePJ.PriceDL.StrubleRG.ClarkAW.CoyleJT.DeLongM.Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain.Science.1982215123712397058341
   PubMed Web of Science ®Google Scholar
• FrancisPT.PalmerAM.SnapeM.ilcock GK. The cholinergic hypothesis of Alzheimer's disease: a review of progress.J Neurol Neurosurg Psychiatry.19996613714710071091
   PubMed Web of Science ®Google Scholar
• LittleJT.JohnsonDN.MinichielloM.WeingartnerH.SunderlandT.Combined nicotinic and muscarinic blockade in elderly normal volunteers: cognitive, behavioral, and physiologic responses.Neuropsychopharmacology:19981960699608577
   PubMed Web of Science ®Google Scholar
• MohsRC.RosenWG.DavisKL.The Alzheimer's disease assessment scale: an instrument for assessing treatment efficacy.Psychopharmacol Bull.1983194484506635122
   PubMed Web of Science ®Google Scholar
• RosenWG.MohsRC.DavisKL.A new rating scale for Alzheimer's disease.Am J Psychiatry.1984141135613646496779
   PubMed Web of Science ®Google Scholar
• FolsteinMF.FolsteinSE.McHughPH.Mini-Mental State: a practical method for grading the cognitive state of patients for the clinician.J Psychiatr Res.1975121891981202204
   PubMed Web of Science ®Google Scholar
• BrooksJ.KraemerH.TankeE.YesavageJ.The methodology of studying decline in Alzheimer's disease.J Am Geriatr Soc.1993416236288505459
   PubMed Web of Science ®Google Scholar
• ClarkCM.SheppardL.FillenbaumGG.et al.Variability in annual Mini-Mental State Examination score in patients with probable Alzheimer disease: a clinical perspective of data from the Consortium to Establish a Registry for Alzheimer's Disease.Arch Neurol.19995685786210404988
   PubMed Web of Science ®Google Scholar
• SalmonDP.ThalLJ.ButtersN.HeindelWC.Longitudinal evaluation of dementia of the Alzheimer type: a comparison of 3 standardized mental status examinations.Neurology.199040122512302381530
   PubMed Web of Science ®Google Scholar
• DavisKL.ThalLJ.GamzuER.et al.A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease. The Tacrine Collaborative Study Group.N Engl J Med.1992327125312591406817
   PubMed Web of Science ®Google Scholar
• FarlowM.GraconSI.HersheyLA.LewisKW.SadowskyCH.Dolan-UrenoJ.A controlled trial of tacrine in Alzheimer's disease. The Tacrine Study Group.JAMA.1992268252325291404819
   PubMed Web of Science ®Google Scholar
• KnappMJ.KnopmanDS.SolomonPR.PendleburyWW.DavisCS.GraconSI.A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. The Tacrine Study Group.JAMA.19942719859918139083
   PubMed Web of Science ®Google Scholar
• NordbergA.SvenssonAL.Cholinesterase inhibitors in the treatment of Alzheimer's disease: a comparison of tolerability and pharmacology [published erratum appears in Drug Saf. 1999;20:146].Drug Saf.1998194654809880090
   PubMed Web of Science ®Google Scholar
• SchneiderLS.New therapeutic approaches to cognitive impairment.J Clin Psychiatry.199859(suppl ll)8139731544
   PubMed Web of Science ®Google Scholar
• RogersSL.DoodyRS.MohsRC.et al.Donepezil improves cognition and global function in Alzheimer disease: a 15-week, double-blind, placebocontrolled study.Arch Intern Med.1998158102110319588436
   PubMed Web of Science ®Google Scholar
• SirvioJ.Strategies that support declining cholinergic neurotransmission in Alzheimer's disease patients.Gerontology.1999453149876213
   PubMed Web of Science ®Google Scholar
• HommaA.TakedaM.ImaiY.et al.Clinical efficacy and safety of donepezil on cognitive and global function in patients with Alzheimer's disease. A 24-week, multicenter, double-blind, placebo-controlled study in Japan. EZOZO Study Group.Dement Geriatr Cogn Disord.20001129931311044775
   PubMed Web of Science ®Google Scholar
• RogersSL.FriedhoffLT.The efficacy and safety of donepezil in patients with Alzheimer's disease: results of a US multicentre, randomized, doubleblind, placebo-controlled trial. The Donepezil Study Group.Dementia.199672933038915035
   PubMedGoogle Scholar
• FotiouF.FountoulakisKN.TsolakiM.GoulasA.PalikarasA.Changes in pupil reaction to light in Alzheimer's disease patients: a preliminary report.Int J Psychophysiol.20003711112010828379
   PubMed Web of Science ®Google Scholar
• EnzA.AmstutzR.BoddekeH.GmelinG.MalanowskiJ.Brain selective inhibition of acetylcholinesterase: a novel approach to therapy for Alzheimer's disease.Prog Brain Res.1993984314388248533
   PubMed Web of Science ®Google Scholar
• StahlSM.The new cholinesterase inhibitors for Alzheimer's disease. Part 1: their similarities are different.J Clin Psychiatry.20006171071111078030
   PubMed Web of Science ®Google Scholar
• RosierM.AnandR.Cicin-SainA.et al.Efficacy and safety of rivastigmine in patients with Alzheimer's disease: international randomised controlled trial.BMJ.199931863363810066203
   PubMedGoogle Scholar
• BirksJ.lakovidouV.TsolakiM.Rivastigmine for Alzheimer's disease.Cochrane Database Syst Rev.20002CD00119110796621
   PubMedGoogle Scholar
• FarlowM.AnandR.MessinaJJ.HartmanR.VeachJ.A 52-week study of the efficacy of rivastigmine in patients with mild to moderately severe Alzheimer's disease.Eur Neurol.20004423624111096224
   PubMed Web of Science ®Google Scholar
• KrallWJ.SramekJJ.CutlerNR.Cholinesterase inhibitors: a therapeutic strategy for Alzheimer disease.Ann Pharmacother.19993344145010332536
   PubMed Web of Science ®Google Scholar
• RaskindMA.PeskindER.WesselT.YuanW.Galantamine in AD: a 6-month randomized, placebo-controlled trial with a 6-month extension. The Galantamine USA-1 Study Group.Neurology.2000542261226810881250
   PubMed Web of Science ®Google Scholar
• TariotPN.ErbR.LeiboviciA.et al.Carbamazepine treatment of agitation in nursing home patients with dementia: a preliminary study.J Am Geriatr Soc.199442116011667963202
   PubMed Web of Science ®Google Scholar
• WilcockG.LilienfeldS.GaensE.Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease: multicentre randomised controlled trial. Galantamine International-1 Study Group.BMJ.20003211445144911110737
   PubMed Web of Science ®Google Scholar
• WilkinsonD.LiliendeldS.TruyenL.Galantamine improves activités of daily living in patients with Alzheimer's disease: a 3 month, placebo-controlled study. Sixth international Stockholm/Springfield Symposium on Advances in Alzheimer Therapy. Stockholm, Sweden, 2000. Abstract.
   Google Scholar
• KnopmanD.SchneiderL.DavisK.et al.Long-term tacrine (Cognex) treatment: effects on nursing home placement and mortality. Tacrine Study Group.Neurology.1996471661778710072
   PubMed Web of Science ®Google Scholar
• NordbergA.Effect of long-term treatment with tacrine (THA) in Alzheimer's disease as visualized by PET.Acta Neurol Scand Suppl.199314962658128843
   PubMedGoogle Scholar
• HauberAB.GnanasakthyA.SnyderEH.BalaMV.RichterA.MauskopfJA.Potential savings in the cost of caring for Alzheimer's disease. Treatment with rivastigmine.Pharmacoeconomics.20001735136010947490
   PubMed Web of Science ®Google Scholar
• FennP.GrayA.Estimating long-term cost savings from treatment of Alzheimer's disease. A modelling approach.Pharmacoeconomics.19991616517410539397
   PubMed Web of Science ®Google Scholar
• FraserM.SnyderEH.The economic benefits of delaying progression in Alzheimer's disease using cholinesterase inhibitors.Clin Geriatr.200087293
   Google Scholar
• GahtanE.OvermierJB.Inflammatory pathogenesis in Alzheimer's disease: biological mechanisms and cognitive sequeli.Neurosci Biobehav Rev.19992361563310392655
   PubMed Web of Science ®Google Scholar
• CacabelosR.TakedaM.WinbladB.The glutamatergic system and neurodegeneration in dementia: preventive strategies in Alzheimer's disease.Int J Geriatr Psychiatry.19991434710029935
   PubMed Web of Science ®Google Scholar
• WinbladB.PoritisN.Memantine in severe dementia: results of the 9M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine).Int J Geriatr Psychiatry.19991413514610885864
   PubMed Web of Science ®Google Scholar
• IngramE.TesslerS.BoweryN.EmsonP.Glial glutamate transporter mRNAs in the genetically absence epilepsy rat from Strasbourg.Brain Res Mol Brain Res.2000759610410648892
   PubMedGoogle Scholar
• CutlerNR.FakouhiTD.SmithWT.et al.Evaluation of multiple doses of milacemide in the treatment of senile dementia of the Alzheimer's type.J Geriatr Psychiatry Neurol.199361151198512628
   PubMedGoogle Scholar
• DyskenMW.MendelsJ.LeWittP.et al.Milacemide: a placebo-controlled study in senile dementia of the Alzheimer type.J Am Geriatr Soc.1992405035061634705
   PubMed Web of Science ®Google Scholar
• LynchG.GrangerR.Ambros-lngersonJ.DavisCM.KesslerM.SchehrR.Evidence that a positive modulator of AMPA-type glutamate receptors improves delayed recall in aged humans.Exp Neurol.199714589929184112
   PubMed Web of Science ®Google Scholar
• GuezD.Long-term effects and safety of almitrine-raubasine in ageassociated cognitive decline.Clin Neuropharmacol.199413S109S1162093415
   PubMedGoogle Scholar
• RiedelWJ.JoliesJ.Cognition enhancers in age-related cognitive decline.Drugs Aging.199682452748920174
   PubMed Web of Science ®Google Scholar
• AllainH.NeumanE.MalbezinM.et al.Bridging study of S12024 in 53 in-patients with Alzheimer's disease.J Am Geriatr Soc.1997451251268994509
   PubMed Web of Science ®Google Scholar
• MedaL.BonaiutoC.SzendreiGl.CeskaM.RossiF.CassatellaMA.β-Amyloid(25-35) induces the production of interleukin-8 from human monocytes.J Neuroimmunol.19955929337797618
   PubMed Web of Science ®Google Scholar
• GiulianD.HaverkampLJ.YuJ.et al.Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia.J Neurosci.199616602160378815885
   PubMed Web of Science ®Google Scholar
• AuldDS.KarS.QuirionR.Beta-amyloid peptides as direct cholinergic neuromodulators: a missing link?Trends Neurosci.19982143499464686
   PubMed Web of Science ®Google Scholar
• YamadaKA.Therapeutic potential of positive AMPA receptor modulators in the treatment of neurological disease.Expert Opin Invest Drugs.20009765778
   PubMed Web of Science ®Google Scholar
• YamadaK.TanakaT.HanD.SenzakiK.KameyamaT.NabeshimaT.Protective effects of idebenone and alpha-tocopherol on beta-amyloid-(1-42)-induced learning and memory deficits in rats: implication of oxidative stress in beta-amyloid-induced neurotoxicity in vivo.Eur J Neurosci.19991183909987013
   PubMed Web of Science ®Google Scholar
• CitronM.Secretases as targets for the treatment of Alzheimer's disease.Mol Med Today.2000639239711006528
   PubMedGoogle Scholar
• SchenkD.BarbourR.DunnW.et al.Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse.Nature.199940017317710408445
   PubMed Web of Science ®Google Scholar
• ItagakiS.AkiyamaH.SaitoH.McGeerPL.Ultrastructural localization of complement membrane attack complex (MAC)-like immunoreactivity in brains of patients with Alzheimer's disease.Brain Res.199464578848062101
   PubMed Web of Science ®Google Scholar
• RogersJ.KirbyLC.HempelmanSR.et al.Clinical trial of indomethacin in Alzheimer's disease.Neurology.199343160916118351023
   PubMed Web of Science ®Google Scholar
• AisenPS.DavisKL.BergJD.et al.A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study.Neurology.20005458859310680787
   PubMed Web of Science ®Google Scholar
• CummingsJL.VintersH.ColeG.et al.Alzheimer's disease: etiologies, pathophysiology, cognitive reserve and treatment opportunities.Neurology.199851S2S179674758
   PubMed Web of Science ®Google Scholar
• ChangJY.LiuLZ.Manganese potentiates nitric oxide production by microglia.Brain Res Mol Brain Res.199968222810320780
   PubMedGoogle Scholar
• PasinettiG.Cyclooxygenase and inflammation in Alzheimer's disease: experimental approaches and clinical interventions.J Neurosci Res.199854169778144
   PubMed Web of Science ®Google Scholar
• SmallG.Treatment of Alzheimer's disease: current approaches and promising developments.Am J Med.199810432S38S9617851
   PubMedGoogle Scholar
• ChristenY.CostentinJ.LacourM.Effects of Ginkgo biloba Extract (EGb 761) on the Central Nervous System. Paris, France: Elsevier;1992
   Google Scholar
• ClostreF. Ginkgo biloba extract (EGb 761). State of knowledge in the dawn of the year 2000.Ann Pharm Fr.1999575888
   Google Scholar
• KanowskiS.HerrmannWM.StephanK.WierichW.HorrR.Proof of efficacy of the Ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia.Pharmacopsychiatry.19962947568741021
   PubMed Web of Science ®Google Scholar
• HofferberthB.The effect of Ginkgo biloba extract on neurophysiological and psychometric measurement results in patients with psychotic organic brain syndrome. A double-blind study against placebo [in German],Arzneimittelforschung.1989399189222684175
   PubMed Web of Science ®Google Scholar
• RaiGS.ShovlinC.WesnesKA.A double-blind, placebo-controlled study of Ginkgo biloba extract (“tanakan”) in elderly outpatients with mild to moderate memory impairment.Curr Med Res Opin.1991123503552044394
   PubMed Web of Science ®Google Scholar
• Le BarsPL.KatzMM.BermanN.ItilT.FreedmanAM.SchatzbergAF.A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group.JAMA.1997278132713329343463
   PubMed Web of Science ®Google Scholar
• WickelgrenI.Estrogen stakes claim to cognition.Science.19972766756789157544
   PubMed Web of Science ®Google Scholar
• Toran-AllerandCD.MirandaRC.BenthamWD.et al.Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain.Neuropsychol Rev.199231191691300219
   PubMedGoogle Scholar
• WoolleyCS.WeilandNG.McEwenBS.SchwartzkroinPA.Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-medicated synaptic input: correlation with dendritic spine density.J Neurosci.199717184818599030643
   PubMed Web of Science ®Google Scholar
• KawasC.ResnickS.MorrisonA.et al.A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: the Baltimore Longitudinal Study of Aging.Neurology.199748151715219191758
   PubMed Web of Science ®Google Scholar
• TangMX.Effect of oestrogen during menopause on risk and age-ofonset of Alzheimer's disease.Lancet.19963484294328709781
   PubMed Web of Science ®Google Scholar
• AsthanaS.CraftS.BakerLD.et al.Cognitive and neuroendocrine response to transdermal estrogen in postmenopausal women with Alzheimer's disease: results of a placebo-controlled, double-blind, pilot study.Psychoneuroendocrinology19992465767710399774
   PubMed Web of Science ®Google Scholar
• HendersonVW.Paganini-HillA.MillerBL.et al.Estrogen for Alzheimer's disease in women: randomized, double-blind, placebo-controlled trial.Neurology.20005429530110668686
   PubMed Web of Science ®Google Scholar
• MulnardRA.CotmanCW.KawasC.et al.Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. Alzheimer's Disease Cooperative Study.JAMA.20002831007101510697060
   PubMed Web of Science ®Google Scholar
• ShaywitzBA.ShaywitzSE.Estrogen and Alzheimer disease: plausible theory, negative clinical trial.JAMA.20002831055105610697067
   PubMed Web of Science ®Google Scholar
• FarlowMR.LahiriDK.PoirierJ.DavignonJ.SchneiderL.HuiSL.Treatment outcome of tacrine therapy depends on apolipoprotein genotype and gender of the subjects with Alzheimer's disease.Neurology.1998506696779521254
   PubMed Web of Science ®Google Scholar
• GutzmannH.HadlerD.Sustained efficacy and safety of idebenone in the treatment of Alzheimer's disease: update on a 2-year double-blind multicentre study.J Neural Transm Suppl.1998543013109850939
   PubMedGoogle Scholar
• CroisileB.TrilletM.FondaraiJ.LaurentB.MauguiereF.BillardonM.Long-term and high-dose piracetam treatment of Alzheimer's disease.Neurology.1993433013058437693
   PubMed Web of Science ®Google Scholar
• VernonMW.SorkinEM.Piracetam. An overview of its pharmacological properties and a review of its therapeutic use in senile cognitive disorders.Drugs Aging.1991117351794001
   PubMedGoogle Scholar
• TariskaP.PaksyA.Cognitive enhancement effect of piracetam in patients with mild cognitive impairment and dementia [in Hungarian].Orv Hetil.20001411189119310853348
   PubMedGoogle Scholar
• FlickerL.Grimley-EvansJ.Piracetam for dementia or cognitive impairment.Cochrane Database Syst Rev.20002CD00101110796585
   PubMedGoogle Scholar
• WindischM.Approach towards an integrative drug treatment of Alzheimer's disease.J Neural Transm Suppl.20005930013013
   Google Scholar
• AlvarezX.LombardiV.CorzoL.et al.Oral Cerebrolysin enhances brain alpha activity and improves cognitive performance in elderly control subjects.J Neural Transm Suppl.20005931532810961443
   PubMedGoogle Scholar
• BaeCY.ChoCY.ChoK.et al.A double-blind, placebo-controlled, multicenter study of Cerebrolysin for Alzheimer's disease.J Am Geriatr Soc.2000481566157111129744
   PubMed Web of Science ®Google Scholar
• RutherE.RitterR.ApececheaM.FreytagS.GmeinbauerR.WindischM.Sustained improvements in patients with dementia of Alzheimer's type (DAT) 6 months after termination of Cerebrolysin therapy.J Neural Transm.200010781582911005546
   PubMed Web of Science ®Google Scholar
• SapolskyRM.KreyLC.McEwenBS.Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging.J Neurosci.19855122212273998818
   PubMed Web of Science ®Google Scholar
• SapolskyR.Why stress is bad for your brain.Science.19862737497508701325
   PubMedGoogle Scholar
• McEwenB.Protective and damaging effects of stress mediators.N Engl J Med.19983381711799428819
   PubMed Web of Science ®Google Scholar
• McEwenB.Stress and the aging hippocampus.Neuroendocrinology.1999204970
   Web of Science ®Google Scholar
• DavisKL.DavisBM.GreenwaldBS.et al.Cortisol and Alzheimer's disease, I: Basal studies.Am J Psychiatry.19861433003053953862
   PubMed Web of Science ®Google Scholar
• HollanderE.MohsRC.DaviesKL.Cholinergic approaches to the treatment of Alzheimer's disease.Br Med Bull.198642971003006861
   PubMed Web of Science ®Google Scholar
• O'BrienJT.AmesD.SchweiterI.MastwykM.ColmanP.Enhanced adrenal sensitivity to adrenocorticotrophic hormone (ACTH) is evidence of HPA axis hyperactivity in Alzheimer's disease.Psychol Med1996267148643765
   PubMed Web of Science ®Google Scholar
• SwaabDF.RaadsheerFC.EndertE.HofmanMA.KamphorstW.RavidR.Increased Cortisol levels in aging and Alzheimer's disease in postmortem cerebrospinal fluid.J Neuroendocrinol.199466816877894471
   PubMed Web of Science ®Google Scholar
• BalldinJ.BlennowK.BraneG.et al.Relationship between mental impairment and HPA axis activity in dementia disorders.Dementia.199452522567951682
   PubMedGoogle Scholar
• MagriF.TerenziF.RicciardiT.et al.Association between changes in adrenal secretion and cerebral morphometric correlates in normal aging and senile dementia.Dement Geriatr Cogn Disord.200011909910705166
   PubMed Web of Science ®Google Scholar
• MillerT.TaylorJ.RogersonS.et al.Cognitive and noncognitive symptoms in dementia patients: relationship to Cortisol and dehydroepiandrosterone (DHEA).Int Psychogeriatr.19981085969629527
   PubMedGoogle Scholar
• WeinerMF.VobachS.SvetlikD.RisserRC.Cortisol secretion and Alzheimer's disease progression: a preliminary report.Biol Psychiatry.1993341581618399808
   PubMed Web of Science ®Google Scholar
• WeinerMF.VobachS.OlssonK.SvetlikD.RisserRC.Cortisol secretion and Alzheimer's disease progression.Biol Psychiatry.199742103010389386855
   PubMed Web of Science ®Google Scholar
• FranceschiM.AiraghiL.GramignaC.et al.ACTH and Cortisol secretion in patients with Alzheimer's disease.J Neurol Neurosurg Psychiatry.1991548368371659618
   PubMed Web of Science ®Google Scholar
• SwanwickGR.KirbyM.BruceI.et al.Hypothalamic-pituitary-adrenal axis dysfunction in Alzheimer's disease: lack of association between longitudinal and cross-sectional findings.Am J Psychiatry.19981552862899464214
   PubMed Web of Science ®Google Scholar
• TsolakiM.KaramouzisM.DivanoglouD.et al.Dehydroepiandrosterone sulfate (DHEAS) in the serum of patients with dementia.Bio Psychol.19974293 Abstract.
   Google Scholar
• Di lorioA.ZitoM.LupinettiM.AbateG.Are vascular factors involved in Alzheimer's disease? Facts and theories.Aging Clin Exp Res.199911345352
   Web of Science ®Google Scholar
• EliasMF.WolfPA.D'AgostinoRB.CobbJ.WhiteLR.Untreated blood pressure level is inversely related to cognitive functioning: the Framingham study.Am J Epidemiol.19931383533648213741
   PubMed Web of Science ®Google Scholar
• EliasMF.Effects of chronic hypertension on cognitive functioning.Geriatrics.199853S49S529745638
   PubMed Web of Science ®Google Scholar
• KilanderL.NymanH.BobergM.HanssonL.LithellH.Hypertension is related to cognitive impairment: a 20-year follow-up of 999 men.Hypertension.1998317807869495261
   PubMed Web of Science ®Google Scholar
• LaunerLJ.MasakiK.PetrovitchH.FoleyD.HavlikRJ.The association between midlife blood pressure levels and late-life cognitive function. The Honolulu-Asia Aging Study.JAMA.1995274184618517500533
   PubMed Web of Science ®Google Scholar
• SkoogI.The relationship between blood pressure and dementia: a review.Biomed Pharmacother.1997513673759452785
   PubMed Web of Science ®Google Scholar
• HofmanA.OttA.BretelerMM.et al.Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study.Lancet.19973491511549111537
   PubMed Web of Science ®Google Scholar
• HallED.OostveenJA.DunnE.CarterDB.Increased amyloid protein precursor and apolipoprotein E immunoreactivity in the selectively vulnerable hippocampus following transient forebrain ischemia in gerbils.Exp Neurol.199513517277556550
   PubMed Web of Science ®Google Scholar
• SparksDL.ScheffSW.LiuH.LandersTM.CoyneCM.HunsakerJC.Increased incidence of neurofibrillary tangles (NFT) in non-demented individuals with hypertension.J Neurol Sci.19951311621697595642
   PubMed Web of Science ®Google Scholar
• Perez-StableEJ.HallidayR.GardinerPS.et al.The effects of propranolol on cognitive function and quality of life: a randomized trial among patients with diastolic hypertension.Am J Med.200010835936510759091
   PubMed Web of Science ®Google Scholar
• ForetteF.SeuxM.StaessenJ.et al.Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial.Lancet.1998352134713519802273
   PubMed Web of Science ®Google Scholar
• RefoloLM.PappollaMA.MalesterB.et al.Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model.Neurobiol Dis.2000732133110964604
   PubMed Web of Science ®Google Scholar
• SparksDL.MartinTA.GrossDR.HunsakerJC 3rd.Link between heart disease, cholesterol, and Alzheimer's disease: a review.Microsc Res Tech.20005028729010936882
   PubMed Web of Science ®Google Scholar
• EckertGP.CairnsNJ.MarasA.GattazWF.MullerWE.Cholesterol modulates the membrane-disordering effects of beta-amyloid peptides in the hippocampus: specific changes in Alzheimer's disease.Dement Geriatr Cogn Disord.20001118118610867442
   PubMed Web of Science ®Google Scholar
• de-AndradeFM.LarrandaburuM.Callegari-JacquesSM.GastaldoG.HutzMH.Association of apolipoprotein E polymorphism with plasma lipids and Alzheimer's disease in a Southern Brazilian population.Braz J Med Biol Res.20003352953710775884
   PubMed Web of Science ®Google Scholar
• EvansRM.EmsleyCL.GaoS.et al.Serum cholesterol, APOE genotype, and the risk of Alzheimer's disease: a population-based study of African Americans.Neurology.20005424024210636159
   PubMed Web of Science ®Google Scholar
• LiuHC.HongCJ.WangSJ.et al.ApoE genotype in relation to AD and cholesterol: a study of 2326 Chinese adults.Neurology.19995396296610496253
   PubMed Web of Science ®Google Scholar
• NotkolaIL.SulkavaR.PekkanenJ.et al.Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease.Neuroepidemiology19981714209549720
   PubMed Web of Science ®Google Scholar
• WehrH.ParnowskiT.PuzynskiS.et al.Apolipoprotein E genotype and lipid and lipoprotein levels in dementia.Dement Geriatr Cogn Disord.200011707310705163
   PubMed Web of Science ®Google Scholar
• RomasSN.TangMX.BerglundL.MayeuxR.APOE genotype, plasma lipids, lipoproteins, and AD in community elderly.Neurology.19995351752110449113
   PubMed Web of Science ®Google Scholar
• PrinceM.LovestoneS.CervillaJ.et al.The association between APOE and dementia does not seem to be mediated by vascular factors.Neurology.20005439740210668701
   PubMed Web of Science ®Google Scholar
• WolozinB.KellmanW.RuosseauP.CelesiaGG.SiegelG.Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.Arch Neurol.1999571439144311030795
   PubMedGoogle Scholar
• SchneiderLS.FarlowM.Combined tacrine and estrogen replacement therapy in patients with Alzheimer's disease.Ann N Y Acad Sci.19978263173229329702
   PubMed Web of Science ®Google Scholar
• SanoM.ErnestoC.ThomasRG.et al.A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study.N Engl J Med.1997336121612229110909
   PubMed Web of Science ®Google Scholar
• PoirierJ.Apolipoprotein E4, cholinergic integrity and the pharmacogenetics of Alzheimer's disease.J Psychiatry Neurosci.19992414715310212558
   PubMed Web of Science ®Google Scholar
• FarlowMR.EvansRM.Pharmacologic treatment of cognition in Alzheimer's dementia.Neurology.199851S36S449674761
   PubMed Web of Science ®Google Scholar
• RichardF.HelbecqueN.NeumanE.GuezD.LevyR.AmouyelP.APOE genotyping and response to drug treatment in Alzheimer's disease.Lancet.19973495399048794
   PubMed Web of Science ®Google Scholar
• WilcockG.LilienfeldS.Galantamine alleviates caregiver burden in Alzheimer's disease: a 6-month placebo-controlled study. Seventh World Alzheimer Congress. Washington, DC, 2000. Poster.
   Google Scholar
• ReichmanW.Alzheimer's disease: clinical treatment options.Am J ManagCare.20006S1125S1132Discussion S1133S1128
   Google Scholar
• Kasl-GodleyJ.GatzM.Psychosocial interventions for individuals with dementia: an integration of theory, therapy, and a clinical understanding of dementia.Clin Psychol Rev.20002075578210983267
   PubMed Web of Science ®Google Scholar
• BaldelliMV.PiraniA.MottaM.AbatiE.MarianiE.ManziV.Effects of reality orientation therapy on elderly patients in the community.Arch Gerontol Geriatr.19931721121815374320
   PubMed Web of Science ®Google Scholar
• ZanettiO.FrisoniGB.De LeoD.Dello BuonoM.BianchettiA.TrabucchiM.Reality orientation therapy in Alzheimer disease: useful or not? A controlled study.Alzheimer Dis Assoc Disord.199591321388534411
   PubMed Web of Science ®Google Scholar
• GreeneJG.TimburyGC.SmithR.GardinerM.Reality orientation with elderly patients in the community: an empirical evaluation.Age Ageing.19831238436846091
   PubMed Web of Science ®Google Scholar
• HanleyIG.LustyK.Memory aids in reality orientation: a single-case study.Behav Res Ther.1983227097126517833
   PubMed Web of Science ®Google Scholar
• BourgeoisMS.Enhancing conversation skills in patients with Alzheimer's disease using a prosthetic memory aid.J Appl Behav Anal.19902329422139873
   PubMed Web of Science ®Google Scholar
• GoldwasserAN.AuerbachSM.HarkinsSW.Cognitive, affective, and behavioral effects of reminiscence group therapy on demented elderly.Int J Aging Hum Dev.1987252092223429043
   PubMed Web of Science ®Google Scholar
• BainesS.SaxbyP.EhlertK.Reality orientation and reminiscence therapy. A controlled cross-over study of elderly confused people.Br J Psychiatry.19871512222313318991
   PubMed Web of Science ®Google Scholar
• HeadDM.PortnoyS.WoodsRT.The impact of reminiscence groups in two different settings.Int J Geriatr Psychol.19905295302
   Web of Science ®Google Scholar
• TeriL.Gallagher-ThompsonD.Cognitive-behavioral interventions for treatment of depression in Alzheimer's patients.Gerontologist.1991314134161879719
   PubMed Web of Science ®Google Scholar
• TeriL.RabinsP.WhitehouseP.et al.Management of behavior disturbance in Alzheimer disease: current knowledge and future directions.Alzheimer Dis Assoc Disord.1992677881389083
   PubMed Web of Science ®Google Scholar
• MittelmanM.FerrisS.ShulmanE.SteinbergG.LevinB.A family intervention to delay nursing home placement of patients with Alzheimer disease. A randomized controlled trial.JAMA.1996276172517318940320
   PubMed Web of Science ®Google Scholar
• MillerPA.ButinD.The role of occupational therapy in dementia - COPE (Caregiver Options for Practical Experiences).Int J Geriatr Psychiatry.200015868910637409
   PubMed Web of Science ®Google Scholar
• SkoogI.GustafsonD.HRT and dementia.J Epidemiol Biostat.19994227251 Discussion 25210695961
   PubMedGoogle Scholar
• CraikFS.SalthouseTA.eds.The Handbook of Aging and Cognition. Hillsdale, NJ: Lawerence Erlbaum Associates;1992
   Google Scholar
• La RueA.Aging and Neuropsychological Assessment. New York, NY: Plenum Press;1992
   Google Scholar
• SalthouseTA.Theoretical Perspectives on Cognitive Aging. Hillsdale, NJ: Lawrence Erlbaum Associates;1991
   Google Scholar
• HertzogC.SchaieKW.Stability and change in adult intelligence. 2. Simultaneous analysis of longitudinal means and covariance structures.Psychol Aging.198831221303268250
   PubMed Web of Science ®Google Scholar
• La RueA.SwandaR.Neuropsychological assessment. In: Nussbaum PD, ed.Neuropsychological Assessment. New York, NY: Plenum Press;1997
   Google Scholar
• SchaieKW.Intellectual development in adulthood. In: Birren JE, Schaie KW, eds.Handbook of the Psychology of Aging. 3rd ed. San Diego, Calif: Academic Press;1990222233
   Google Scholar
• TaylorJL.MillerTP.TinklenbergJR.Correlates of memory decline. A 4-year longitudinal study of older adults with memory complaints.Psychol Aging.199271851931610506
   PubMed Web of Science ®Google Scholar
• RabbittP.Applied cognitive gerontology: some problems, methodologies and data.Appl Cogn Psychol.19904225246
   Web of Science ®Google Scholar
• HultschDF.DixonRA.Learning and memory in aging. In: Birren JE, Schaie KW, eds.Handbook of the Psychology of Aging. 3rd ed. San Diego, Calif: Academic Press;1999258274
   Google Scholar
• LightL.The organization of memory in old age. In: Craik FIM, Salt-house TA, eds.The Handbook of Aging and Cognition. Hillsdale, NJ: Lawrence Erlbaum Associates;1992111165
   Google Scholar
• DobbsAR.RuleBG.Prospective memory and self-reports of memory abilities in older adults.Can J Psychol.1987412092223502897
   PubMed Web of Science ®Google Scholar
• LeirerVO.MorrowDG.SheikhJl.ParianteGM.Memory skills elders want to improve.Exp Aging Res.1990161551582090468
   PubMed Web of Science ®Google Scholar
• PetersenRC.Aging, mild cognitive impairment, and Alzheimer's disease.Neurol Clin.20001878980611072261
   PubMed Web of Science ®Google Scholar
• FerrisSH.KlugerA.Commentary on age-associated memory impairment, age-related cognitive decline and mild cognitive impairment.Aging Neuropsychol Cogn.19963148153
   Web of Science ®Google Scholar
• CrookT.BartusRT.FerrisSH.et al.Age-associated memory impairment: proposed diagnostic criteria and measures of clinical change. Report of a National Institute of Mental Health workgroup.Dev Neuropsychol.19862261276
   Web of Science ®Google Scholar
• LevyR.Aging-associated cognitive decline.Int Psychogeriatr.1994663688054494
   PubMedGoogle Scholar
• RitchieK.ArteroS.TouchonJ.Classification criteria for mild cognitive impairment: a population-based validation study.Neurology.200156374211148233
   PubMed Web of Science ®Google Scholar
• SherwinB.Mild cognitive impairment: potential pharmacological treatment options.J Am Geriatr Soc.20004843144110798472
   PubMed Web of Science ®Google Scholar
• McGeerE.McGeerPL.Age changes in the human for some enzymes associated with metabolism of catecholamines, GABA, and acetylcholine. In: Ordee JM, Brizee RR, eds.Neurobiology of Aging. New York, NY: Raven Press;1976
   Google Scholar
• WhiteP.HileyCR.GoodhardtMJ.et al.Neocortical cholinergic neurons in elderly people,Lancet.1977166867166473
   PubMed Web of Science ®Google Scholar
• BaxterMG.FrickKM.PriceDL.et al.Presynaptic markers of cholinergic function in the rat brain: relationship with age and cognitive status.Neuroscience.19998977177910199612
   PubMed Web of Science ®Google Scholar
• DavisKL MR.MarinD.PurohitDP.et al.Cholinergic markers in elderly patients with early signs of Alzheimer disease.JAMA.19992811401140610217056
   PubMed Web of Science ®Google Scholar
• HarderJA.BakerHF.RidleyRM.The role of the central cholinergic projections in cognition: implications of the effects of scopolamine on discrimination learning by monkeys.Brain Res Bull.1998453193269510426
   PubMed Web of Science ®Google Scholar
• MolchanS.MartinezRA.HillJL.et al.Increased cognitive sensitivity to scopolamine with age and a perspective on the scopolamine model.Brain Res Brain Res Rev.1992172152161467811
   PubMedGoogle Scholar
• FibigerHC.Cholinergic mechanisms in learning, memory and dementia: a review of recent evidence.Trends Neurosci.1991142202231716012
   PubMed Web of Science ®Google Scholar
• MohammedAH.Effects of cholinesterase inhibitors on learning and memory in rats: a brief review with special reference to THA.Acta Neurol Scand Suppl.199314913158128832
   PubMedGoogle Scholar
• SiegfriedKR.Pharmacodynamic and early clinical studies with velnacrine.Acta Neurol Scand Suppl.199314926288128834
   PubMedGoogle Scholar
• SitaramN.WeingartnerH.GillinJC.Human serial learning: enhancement with arecholine and choline impairment with scopolamine.Science.1978201274276351808
   PubMed Web of Science ®Google Scholar
• ChristieJE.SheringA.FergusonJ.GlenAl.Physostigmine and arecoline: effects of intravenous infusions in Alzheimer presenile dementia.Br J Psychiatry.198113846507023592
   PubMed Web of Science ®Google Scholar
• BraidaD.PaladiniE.GriffiniP.et al.Long-lasting antiamnesic effect of a novel anticholinesterase inhibitor (MF268).Pharmacol Biochem Behav.1998598979019586846
   PubMed Web of Science ®Google Scholar
• DawsonGR.IversenSD.The effects of novel cholinesterase inhibitors and selective muscarinic receptor agonists in tests of reference and working memory.Behav Brain Res.1993571431538117420
   PubMed Web of Science ®Google Scholar
• RupniakNM.TyeSJ.FieldMJ.Enhanced performance of spatial and visual recognition memory tasks by the selective acetylcholinesterase inhibitor E2020 in rhesus monkeys.Psychopharmacology19971314064109226744
   PubMed Web of Science ®Google Scholar
• FureyML.PietriniP.HaxbyJV.et al.Cholinergic stimulation alters performance and task-specific regional cerebral blood flow during working memory.Proc Natl Acad Sci U S A.199794651265169177249
   PubMed Web of Science ®Google Scholar
• FureyML.PietriniP.HaxbyJV.Cholinergic enhancement and increased selectivity of perceptual processing during working memory.Science.20002902315231911125148
   PubMed Web of Science ®Google Scholar
• MuirJL.Acetylcholine, aging, and Alzheimer's disease.Pharmacol Biochem Behav.1997566876969130295
   PubMed Web of Science ®Google Scholar
• SchwartzBL.HashtroudiS.HertingRL.HandersonH.DeutschSI.Glycine prodrug facilitates memory retrieval in humans.Neurology.199141134113431653913
   PubMed Web of Science ®Google Scholar
• SchwartzBL.HashtroudiS.HertingRL.DeutschSI.The effects of milacemide on item and source memory.Clin Neuropharmacol.1992151141191591737
   PubMed Web of Science ®Google Scholar
• SaletuB.GrunbergerJ.LinzmayerL.Acute and subacute CNS effects of milacemide in elderly people: double-blind, placebo-controlled quantitative EEG and psychometric investigations.Arch Gerontol Geriatr.198651651813541816
   PubMed Web of Science ®Google Scholar
• JonesRW.WesnesKA.KirbyJ.Effects of NMDA modulation in scopolamine dementia.Ann N Y Acad Sci.19916402412421837979
   PubMed Web of Science ®Google Scholar
• PeacockJM.FolsomAR.KnopmanDS.MosleyTH.GoffDC.SzkloM.Association of nonsteroidal anti-inflammatory drugs and aspirin with cognitive performance in middle-aged adults.Neuroepidemiology19991813414310438276
   PubMed Web of Science ®Google Scholar
• HanlonJT.SchmaderKE.LandermanLR.et al.Relation of prescription nonsteroidal antiinflammatory drug use to cognitive function among community-dwelling elderly.Ann Epidemiol.1997787949099396
   PubMed Web of Science ®Google Scholar
• RozziniR.FerrucciL.LosonczyK.HavlikRJ.GuralnikJM.Protective effect of chronic NSAID use on cognitive decline in older persons.J Am Geriatr Soc.199644102510298790225
   PubMed Web of Science ®Google Scholar
• KarplusTM.SaagKG.Nonsteroidal anti-inflammatory drugs and cognitive function: do they have a beneficial or deleterious effect?Drug Saf.1998194274339880087
   PubMed Web of Science ®Google Scholar
• KennedyDO.ScholeyAB.WesnesKA.The dose-dependent cognitive effects of acute administration of Ginkgo biloba to healthy young volunteers.Psychopharmacology (Berl).200015141642311026748
   PubMed Web of Science ®Google Scholar
• MixJA.CrewsWD.An examination of the efficacy of Ginkgo biloba extract EGb761 on the neuropsychologic functioning of cognitively intact older adults.J Altern Complement Med.2000621922910890330
   PubMed Web of Science ®Google Scholar
• RigneyU.KimberS.HindmarchI.The effects of acute doses of standardized Ginkgo biloba extract on memory and psychomotor performance in volunteers.Phytother Res.19991340841510441781
   PubMed Web of Science ®Google Scholar
• Barrett-ConnorE.Kritz-SilversteinD.Estrogen replacement therapy and cognitive function in older women.JAMA.1993269263726418487446
   PubMed Web of Science ®Google Scholar
• HendersonVW.Paganini-HillA.EmanuelCK.DunnME.BuckwalterJG.Estrogen replacement therapy in older women. Comparisons between Alzheimer's disease cases and nondemented control subjects.Methods Find Exp Clin Pharmacol.1994165976077760585
   PubMedGoogle Scholar
• HendersonVW.WattL.BuckwalterJG.Cognitive skills associated with estrogen replacement in women with Alzheimer's disease.Psychoneuroendocrinology.1996214214308844880
   PubMed Web of Science ®Google Scholar
• Paganini-HillA.HendersonVW.Estrogen deficiency and risk of Alzheimer's disease in women.Am J Epidemiol.19941402562618030628
   PubMed Web of Science ®Google Scholar
• Paganini-HillA.HendersonVW.The effects of hormone replacement therapy, lipoprotein cholesterol levels, and other factors on a clock drawing task in older women.J Am Geriatr Soc.1996448188228675931
   PubMed Web of Science ®Google Scholar
• PhillipsSM.SherwinBB.Effects of estrogen on memory function in surgically menopausal women.Psychoneuroendocrinology.1992174854951484915
   PubMed Web of Science ®Google Scholar
• RobinsonD.FriedmanL.MarcusR.TinklenbergJ.YesavageJ.Estrogen replacement therapy and memory in older women.J Am Geriatr Soc.1994429199228064097
   PubMed Web of Science ®Google Scholar
• DukaT.TaskerR.McGowanJF.The effects of 3-week estrogen hormone replacement on cognition in elderly healthy females.Psychopharmacology (Bert).2000149129139
   PubMed Web of Science ®Google Scholar
• SherwinB.Estrogen and/or androgen replacement therapy in surgically menopausal women.Psychoneuroendocrinology.198829423430
   Google Scholar
• MakiPM.ZondermanAB.ResnickSM.Enhanced verbal memory in nondemented elderly women receiving hormone-replacement therapy.Am J Psychiatry.200115822723311156805
   PubMed Web of Science ®Google Scholar
• HalbreichU.LumleyL.PalterS.et al.Possible acceleration of age effects on cognition following menopause.J Psychiatry Res.199529153163
   PubMed Web of Science ®Google Scholar
• FillenbaumGG.HanlonJT.LandermanLR.SchmaderKE.Impact of estrogen use on decline in cognitive function in a representative sample of older community-resident women.Am J Epidemiol.200115313714411159158
   PubMed Web of Science ®Google Scholar
• SzkloM.CerhanJ.Diez-RouxAV.et al.Estrogen replacement therapy and cognitive functioning in the Atherosclerosis Risk In Communities (ARIC) study.Am J Epidemiol.1996144104810578942436
   PubMed Web of Science ®Google Scholar
• EberlingJL.ReedBR.ColemanJE.JagustWJ.Effect of estrogen on cerebral glucose metabolism in postmenopausal women.Neurology.20005587587710994014
   PubMed Web of Science ®Google Scholar
• MakiPM.ResnickSM.Longitudinal effects of estrogen replacement therapy on PET cerebral blood flow and cognition.Neurobiol Aging.20002137338310867223
   PubMed Web of Science ®Google Scholar
• SherwinBB.Can estrogen keep you smart? Evidence from clinical studies.J Psychiatry Neurosci.19992431532110516798
   PubMed Web of Science ®Google Scholar
• FioravantiM.BergamascoB.BoccolaV.et al.A multicentered, doubleblind, controlled study of piracetam vs placebo in geriatric patients with nonvascular mild-moderate deficits.N Trends Clin Neuropharmacol.199152734
   Google Scholar
• IsraelL.MyslinskiM.DubosG.MelacM.Combined therapies in family practice and hospitals.Presse Med.199726118611919380609
   PubMedGoogle Scholar
• GallaiV.MazzottaG.Del GattoF.et al.A clinical and neurophysiological trial on nootropic drugs in patients with mental decline.Acta Neurol (Napoli).1991131121867125
   PubMedGoogle Scholar
• SchmidtU.BrendemuhlD.EngelsK.SchenkN.LudemannE.Piracetam in elderly motorists.Pharmacopsychiatry.1991241211261754607
   PubMed Web of Science ®Google Scholar
• MondadoriC.PetschkeF.HauslerA.The effects of nootropics on memory: new aspects for basic research.Pharmacopsychiatry.198922(suppl 2)1021062690149
   PubMed Web of Science ®Google Scholar
• MariniG.CarattiC.PelluffoF.et al.Placebo-controlled, double-blind study of pramiracetam in the treatment of elderly subjects with memory impairment.Adv Ther.19929136146
   Web of Science ®Google Scholar
• BackmanL.MantylaT.HerlitzA.The optimization of episodic remembering in old age. In: Baltes PBBMM, ed.Successful Aging: Perspectives from the Behavioral Sciences. New York, NY: Cambridge University Press;1990118163
   Google Scholar
• BrooksJO.III.FriedmanL.PearmanA.GrayC.YesavageJA.Mnemonic training in older adults: effects of age, length of training, and type of cognitive pretraining.Int Psychogeriatry1999117584
   PubMedGoogle Scholar
• VerhaeghenP.MarcoenA.GoossensL.Improving memory performance in the aged through mnemonic training: a meta-analytic study.Psychol Aging.199272422511535198
   PubMed Web of Science ®Google Scholar
• WillisSL.NesselroadeCS.Long-term effects of fluid ability training in old-old age.Dev Psychol.19902616
   Web of Science ®Google Scholar
• YesavageJA.SheikhJl.TankeED.HillRD.Response to memory training and individual differences in verbal intelligence and state anxiety.Am J Psychiatry.19881456366393282452
   PubMed Web of Science ®Google Scholar
• VergheseJ.PTSD, dementia, and sleep disorder: a possible association.J Am Geriatr Soc.2000481169117010983923
   PubMed Web of Science ®Google Scholar
• AnschutzL.CampCJ.MarkleyRP.KramerJJ.Remembering mnemonics: a 3-year follow-up on the effects of mnemonics training in elderly adults.Exp Aging Res.1987131411433691584
   PubMed Web of Science ®Google Scholar
• NeelyA.BackmanL.Long-term maintenance of gains from memory training in older adults: Two 3½-year follow-up studies.J Gerontol Psychol Sci.199348P233P237
   Google Scholar
• ScoginF.BieniasJL.A 3-year follow-up of older adult participants in a memory-skills training program.Psychol Aging.198833343373268276
   PubMed Web of Science ®Google Scholar
• O'HaraR.BrooksJO.FriedmanLF.et al.Long-term effects of mnemonic training on memory performance in 112 community-dwelling older adults.J Gerontol.2002. In press.
   Google Scholar
• IsraelL.MelacM.MilinkevitchD.DubosG.Drug therapy and memory training programs: a double-blind randomized trial of general practice patients with age-associated memory impairment.Int Psychogeriatry.19946155170
   PubMedGoogle Scholar
• GrimbyA.BergS.Stressful life events and cognitive functioning in late life.Aging (Milano).1995735397599246
   PubMedGoogle Scholar
• CreaseyH.SulwayMR.DentO.BroeG.JormA.TennantC.Is experience as a prisoner of war a risk factor for accelerated age-related illness and disability?J Am Geriatr Soc.19994760649920230
   PubMed Web of Science ®Google Scholar
• JohnstonD.A series of cases of dementia presenting with PTSD symptoms in World War II combat veterans.J Am Geriatr Soc.200048707210642025
   PubMed Web of Science ®Google Scholar
• BremmerJD.NarayanM.The effects of stress on memory and the hippocampus throughout the life cycle: implications for childhood development and aging.Dev Psychopathol.1998108718859886231
   PubMed Web of Science ®Google Scholar
• LupienSJ.de LeonM.de SantiS.et al.Cortisol levels during human aging predict hippocampal atrophy and memory deficits.Nat Neurosci.19981697310195112
   PubMed Web of Science ®Google Scholar
• CarlsonLE.SherwinBB.ChertkowHM.Relationships between dehydroepiandrosterone sulfate (DHEAS) and Cortisol (CRT) plasma levels and everyday memory in Alzheimer's disease patients compared to healthy controls.Horm Behav.19993525426310373337
   PubMed Web of Science ®Google Scholar
• SeemanTE.McEwenBS.SingerBH.et al.Increase in urinary Cortisol excretion and memory declines: MacArthur studies of successful aging.J Clin Endocrinol Metab.199782245824659253318
   PubMed Web of Science ®Google Scholar
• KalmijnS.LaunerLJ.StolkRP.et al.A prospective study on Cortisol, dehydroepiandrosterone sulfate, and cognitive function in the elderly.J Clin Endocrinol Metab.199883348734929768651
   PubMed Web of Science ®Google Scholar
• KellyKS.HayslipBJ.Gains in fluid ability performance and their relationship to Cortisol.Exp Aging Res.20002615315710755221
   PubMed Web of Science ®Google Scholar
• LupienSJ.GaudreauS.TchiteyaBM.et al.Stress-induced declarative memory impairment in healthy elderly subjects: relationship to Cortisol reactivity.J Clin Endocrinol Metab.199782207020759215274
   PubMed Web of Science ®Google Scholar
• LupienSJ.McEwenBS.The acute effects of corticosteroids on cognition: integration of animal and human model studies.Brain Res Rev.1997241279233540
   PubMed Web of Science ®Google Scholar
• BerkmanLF.SeemanTE.AlbertM.et al.High, usual and impaired functioning in community-dwelling older men and women: findings from the MacArthur Foundation Research Network on Successful Aging.J Clin Epidemiol.199346112911408410098
   PubMed Web of Science ®Google Scholar
• MoffatSD.ZondermanAB.HarmanSM.BlackmanMR.KawasC.ResnickSM.The relationship between longitudinal declines in dehydroepiandrosterone sulfate concentrations and cognitive performance in older men.Arch Intern Med.20001602193219810904463
   PubMed Web of Science ®Google Scholar
• YaffeK.EttingerB.PressmanA.et al.Neuropsychiatrie function and dehydroepiandrosterone sulfate in elderly women: a prospective study.Biol Psychiatry.1999436947009583004
   PubMed Web of Science ®Google Scholar
• BirrenJE.Sociopsychologic studies of the aging process. Increments and decrements in the intellectual status of the aged.Psychiatr Res Rep Ami Psychiatr Assoc.196823207214
   PubMedGoogle Scholar
• AnsteyK.ChristensenH.Education, activity, health, blood pressure and apolipoprotein E as predictors of cognitive change in old age: a review.Gerontology.20004616317710754375
   PubMed Web of Science ®Google Scholar
• CervillaJA.PrinceM.JoelsS.LovestoneS.MannA.Long-term predictors of cognitive outcome in a cohort of older people with hypertension.Br J Psychiatry.2000177667110945091
   PubMed Web of Science ®Google Scholar
• Di CarloA.BaldereschiM.AmaducciL.et al.Cognitive impairment without dementia in older people: prevalence, vascular risk factors, impact on disability. The Italian Longitudinal Study on Aging.J Am Geriatr Soc.20004877578210894316
   PubMed Web of Science ®Google Scholar
• FontbonneA.BerrC.DucimetiereP.AlperovitchA.Changes in cognitive abilities over a 4-year period are unfavorably affected in elderly diabetic subjects: results of the Epidemiology of Vascular Aging Study.Diabetes Care.20012436637011213894
   PubMed Web of Science ®Google Scholar
• HaanMN.ShemanskiL.JagustWJ.ManolioTA.KullerL.The role of APOE epsilon4 in modulating effects of other risk factors for cognitive decline in elderly persons.JAMA.1999282404610404910
   PubMed Web of Science ®Google Scholar
• BroeGA.CreaseyH.JormAF.et al.Health habits and risk of cognitive impairment and dementia in old age: a prospective study on the effects of exercise, smoking and alcohol consumption?Aust N Z J Public Health.1998226216239744220
   PubMed Web of Science ®Google Scholar
• HassmenP.KoivulaN.Mood, physical working capacity and cognitive performance in the elderly as related to physical activity.Aging (Milano).199791361429177597
   PubMedGoogle Scholar
• HultschDF.HertzogC.SmallBJ.DixonRA.Use it or lose it: engaged lifestyle as a buffer of cognitive decline in aging?Psychol Aging.19991424526310403712
   PubMed Web of Science ®Google Scholar
• BassukSS.GlassTA.BerkmanLF.Social disengagement and incident cognitive decline in community-dwelling elderly persons.Ann Intern Med.199913116517310428732
   PubMed Web of Science ®Google Scholar
• DrebingC.Van GorpW.StuckA.MitrushinaM.BeckJ.Early detection of cognitive decline in higher cognitively functioning older adults: sensitivity and specificity of a neuropsychological screening battery.J Neuropsychol.199483137
   Google Scholar
• DiehlM.WillisSL.SchaieKW.Practical problem solving in older adults: Observational assessment and cognitive correlates.Psychol Aging.1995104784918527068
   PubMed Web of Science ®Google Scholar
• WillisS.Cognitive training and everyday competence.Annu Rev Gerontol Geriatr.198771591883120748
   PubMedGoogle Scholar
• SmallGW.MazziottaJC.CollinsMT.et al.Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer's disease.JAMA.19952739429477884953
   PubMed Web of Science ®Google Scholar
• ReimanEM.CaselliRJ.YunLS.et al.Preclinical evidence of Alzheimer's disease in persons homozygous for the b4 allele for apolipoprotein E.N Engl J Med.19963347527588592548
   PubMed Web of Science ®Google Scholar