Synthesis and biological evaluation of tetrazole ring incorporated oxazole-pyrimidine derivatives as anticancer agents

Abstract

A new library of tetrazole rings with oxazole-pyrimidine derivatives (9a–j) has been developed and synthesized. All of the compounds were characterized using spectral data. These were then tested for in vitro anticancer activity against four human cancer cell lines: prostate cancer (PC3 & DU-145), lung cancer (A549), and breast cancer (MCF-7) using an MTT assay. Etoposide was chosen as the positive control. Most of the compounds demonstrated moderate to good activity. These compounds (9a, 9b, 9d, 9g, and 9h) demonstrated the most powerful action. Particularly, one chemical 9h had exceptional antitumor efficacy.

Graphical Abstract

Keywords:

• Cephalosporin
• infigratinib
• pyrimidine
• 1,2,3,4-tetrazole and anticancer activity

Acknowledgments

The authors are grateful to the Deanship of Scientific Research, King Khalid University for the financial support (Grant No. RGP. 2/21/44).

Declaration of interest

The authors declare that they have no competing interests.

Additional information

Funding

This work was supported by the Deanship of Scientific Research, King Khalid University (Grant No. RGP. 2/21/44).