Polymer–ceramic biocomposites based on PVP/histidine/hydroxyapatite for hard tissue engineering applications

Abstract

Polymer and hydroxyapatite (HAP) composites have growing interest in bone regeneration. Commonly used for these applications is polyvinylpyrrolidone (PVP), which represents excellent biological inertness, is biocompatible, and do not adversely interact with HAP. For this reason, in our studies, we have focused on 3-igreedient biocomposites based on PVP/histidine/HAP investigating their mechanical performance, morphology, swelling property and incubation response. The objective is to determine the effect of histidine on the UV cross-linked hydroxyapatite-polymers composites particularly focused on the role of their composition on structure, mechanical properties, and biocompatibility. The results confirm bioactivity of this material and it desirable features for orthopedics.

Graphical Abstract

Keywords:

• Hydroxyapatite
• drug delivery
• hydrogels
• bio mechanical properties
• swelling properties
• incubation

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The “Multifunctional biologically active composites for applications in bone regenerative medicine” [POIR.04.04.00-00-16D7/18] project is carried out within the TEAM-NET program of the Foundation for Polish Science financed by the European Union under the European Regional Development Fund.

Graphical Abstract