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The International Journal on Orbital Disorders, Oculoplastic and Lacrimal Surgery
Volume 42, 2023 - Issue 1
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Original Investigation

Radiological analysis of orbital lymphoma histological subtypes

, ORCID Icon, , , , , , ORCID Icon & ORCID Icon show all
Pages 59-67 | Received 01 Nov 2021, Accepted 21 Jan 2022, Published online: 22 Feb 2022
 

ABSTRACT

Purpose

To characterise the radiological features of orbital lymphoma subtypes

Methods

This was a multicentre, retrospective study to analyse radiological and clinical characteristics of orbital lymphoma by histological subtype across two sites within Australia and the United States.

Results

A total of eighty-eight patients were included. The most common subtypes were extranodal marginal zone lymphoma [EMZL] (48, 54.5%), follicular lymphoma [FL] (16, 18.2%), and diffuse large B-cell lymphoma [DLBCL] (15, 17.0%). Clinically, significant associations were found between DLBCL and vision change (p < .01), pain (p < .01), extraocular movement limitation (p = .01), and optic neuropathy (p = .01). Radiologically, there was no significant difference between the individual histopathological sub-groups with respect to bone destruction (p = .30), optic nerve involvement (p = .30) and diffuse appearance (p = .84). However, if categorised as either aggressive or indolent, aggressive lymphoma subtypes were significantly more likely to demonstrate globe indentation radiologically than indolent subtypes (Odds Ratio = 5.5, 95% CI: 1.3, 23.3; p = .02).

Conclusions

DLBCL was significantly associated with vision change, pain, extraocular movement limitation and optic neuropathy clinically. Aggressive lymphoma subtypes were significantly more likely to demonstrate globe indentation radiologically. Otherwise, there were no significant differences between lymphoma subtypes and radiological findings on MRI and CT.

Acknowledgments

We wish to acknowledge Suzanne Edwards for statistical analysis.

Disclosure statement

No conflicting relationship exists for any author

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.

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