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Drug Metabolism Reviews Volume 38, 2006 - Issue 1-2
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Research Article

The Biological Actions of Dehydroepiandrosterone Involves Multiple Receptors

Stephanie J. Webb Department of Biochemistry & Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky, USA
,
Thomas E. Geoghegan Department of Biochemistry & Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky, USA
,
Russell A. Prough Department of Biochemistry & Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky, USA
&
Kristy K. Michael Miller Department of Chemistry, University of Evansville, Evansville, Indiana, USA
Pages 89-116 | Published online: 09 Oct 2008
 
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Abstract

Dehydroepiandrosterone has been thought to have physiological functions other than as an androgen precursor. The previous studies performed have demonstrated a number of biological effects in rodents, such as amelioration of disease in diabetic, chemical carcinogenesis, and obesity models. To date, activation of the peroxisome proliferators activated receptor alpha, pregnane X receptor, and estrogen receptor by DHEA and its metabolites have been demonstrated. Several membrane-associated receptors have also been elucidated leading to additional mechanisms by which DHEA may exert its biological effects. This review will provide an overview of the receptor multiplicity involved in the biological activity of this sterol.

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