REFERENCES
- Abuissa H., Bel D. S., O'Keefe J. H., Jr.,. Strategies to prevent type 2 diabetes. Curr. Med. Res. Opin 2005; 21: 1107–1114, [INFOTRIEVE], [CSA]
- Allolio B., Arlt W. DHEA treatment: myth or reality?. Trends Endocrinol. Metab 2002; 13: 288–294, [INFOTRIEVE], [CROSSREF], [CSA]
- Apostolova G., Schweizer R. A., Balazs Z., Kostadinova R. M., Odermatt A. Dehydroepiandrosterone inhibits the amplification of glucocorticoid action in adipose tissue. Am. J. Physiol. Endocrinol. Metab 2005; 288: E957–E964, [INFOTRIEVE], [CROSSREF], [CSA]
- Arad Y., Badimon J. J., Badimon L., Hembree W. C., Ginsberg H. N. Dehydroepiandrosterone feeding prevents aortic fatty streak formation and cholesterol accumulation in cholesterol-fed rabbit. Arteriosclerosis 1989; 9: 159–166, [INFOTRIEVE], [CSA]
- Barger P. M., Brandt J. M., Leone T. C., Weinheimer C. J., Kelly D. P. Deactivation of peroxisome proliferator-activated receptor-alpha during cardiac hypertrophic growth. J. Clin. Invest 2000; 105: 1723–1730, [INFOTRIEVE], [CSA]
- Barger P. M., Browning A. C., Garner A. N., Kelly D. P. Mitogen-activated protein kinase activates peroxisome proliferator-activated receptor alpha: a potential role in the cardiac metabolic stress response. J. Biol. Chem 2001; 276: 44495–44501, [INFOTRIEVE], [CROSSREF], [CSA]
- Barger P. M., Kelly D. P. PPAR signaling in the control of cardiac energy metabolism. Trends Cardiovasc. Med 2000; 10: 238–245, [INFOTRIEVE], [CROSSREF], [CSA]
- Barrett-Connor E., Khaw K. T., Yen S. S. A prospective study of dehydroepiandrosterone sulfate, mortality, and cardiovascular disease. N. Engl. J. Med 1986; 315: 1519–1524, [INFOTRIEVE], [CSA]
- Barrett-Connor E., von Muhlen D., Laughlin G. A., Kripke A. Endogenous levels of dehydroepiandrosterone sulfate, but not other sex hormones, are associated with depressed mood in older women: the Rancho Bernardo study. J. Am. Geriatr. Soc 1999; 47: 685–691, [INFOTRIEVE], [CSA]
- Bayes-Genis A., Conover C. A., Schwartz R. S. The insulin-like growth factor axis: a review of atherosclerosis and restenosis. Circ. Res 2000; 86: 125–130, [INFOTRIEVE], [CSA]
- Ben-Nathan D., Lustig S., Kobiler D., Danenberg H. D., Lupu E., Feuerstein G. Dehydroepiandrosterone protects mice inoculated with West Nile virus and exposed to cold stress. J. Med. Virol 1992; 38: 159–166, [INFOTRIEVE], [CSA]
- Bird C. E., Masters V., Clark A. F. Dehydroepiandrosterone sulfate: kinetics of metabolism in normal young men and women. Clin. Invest Med 1984; 7: 119–122, [INFOTRIEVE], [CSA]
- Blanquart C., Mansouri R., Fruchart J. C., Staels B., Glineur C. Different ways to regulate the PPARalpha stability. Biochem. Biophys. Res. Commun 2004; 319: 663–670, [INFOTRIEVE], [CROSSREF], [CSA]
- Bujalska I. J., Walker E. A., Hewison M., Stewart P. M. A switch in dehydrogenase to reductase activity of 11 beta-hydroxysteroid dehydrogenase type 1 upon differentiation of human omental adipose stromal cells. J. Clin. Endocrinol. Metab 2002; 87: 1205–1210, [INFOTRIEVE], [CROSSREF], [CSA]
- Carr M. C., Brunzell J. D. Abdominal obesity and dyslipidemia in the metabolic syndrome: importance of type 2 diabetes and familial combined hyperlipidemia in coronary artery disease risk. J. Clin. Endocrinol. Metab 2004; 89: 2601–2607, [INFOTRIEVE], [CROSSREF], [CSA]
- Chen F., Knecht K., Birzin E., Fisher J., Wilkinson H., Mojena M., Moreno C. T., Schmidt A., Harada S. I., Freedman L. P., Reszka A. A. Direct agonist/antagonist functions of dehydroepiandrosterone (DHEA). Endocrinology 2005; 146: 4568–4596, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Corton J. C., Fan L. Q., Brown S., Anderson S. P., Bocos C., Cattley R. C., Mode A., Gustafsson J. A. Down-regulation of cytochrome P450 2C family members and positive acute-phase response gene expression by peroxisome proliferator chemicals. Mol. Pharmacol 1998; 54: 463–473, [INFOTRIEVE], [CSA]
- Couse J. F., Lindzey J., Grandien K., Gustafsson J. A., Korach K. S. Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse. Endocrinology 1997; 138: 4613–4621, [INFOTRIEVE], [CROSSREF], [CSA]
- Crossey P. A., Jones J. S., Miell J. P. Dysregulation of the insulin/IGF binding protein-1 axis in transgenic mice is associated with hyperinsulinemia and glucose intolerance. Diabetes 2000; 49: 457–465, [INFOTRIEVE], [CSA]
- de Peretti E., Forest M. G. Pattern of plasma dehydroepiandrosterone sulfate levels in humans from birth to adulthood: evidence for testicular production. J. Clin. Endocrinol. Metab 1978; 47: 572–577, [INFOTRIEVE], [CSA]
- Deen M. Metabolic syndrome: time for action. Am. Fam. Physician 2004; 69: 2875–2882, [INFOTRIEVE], [CSA]
- Delesque-Touchard N., Park S. H., Waxman D. J. Synergistic action of hepatocyte nuclear factors 3 and 6 on CYP2C12 gene expression and suppression by growth hormone-activated STAT5b. Proposed model for female specific expression of CYP2C12 in adult rat liver. J. Biol. Chem 2000; 275: 34173–34182, [INFOTRIEVE], [CROSSREF], [CSA]
- Diradourian C., Girard J., Pegorier J. P. Phosphorylation of PPARs: from molecular characterization to physiological relevance. Biochimie 2005; 87: 33–38, [INFOTRIEVE], [CROSSREF], [CSA]
- Dixon D., Couse J. F., Korach K. S. Disruption of the estrogen receptor gene in mice. Toxicol. Pathol 1997; 25: 518–520, [INFOTRIEVE], [CSA]
- Dubrovsky B. O. Steroids, neuroactive steroids and neurosteroids in psychopathology. Prog. Neuropsychopharmacol. Biol. Psychiatry 2005; 29: 169–192, [INFOTRIEVE], [CROSSREF], [CSA]
- Dussault I., Forman B. M. The nuclear receptor PXR: a master regulator of “homeland” defense. Crit. Rev. Eukaryot. Gene Expr 2002; 12: 53–64, [INFOTRIEVE], [CROSSREF], [CSA]
- Ebeling P., Koivisto V. A. Physiological importance of dehydroepiandrosterone. Lancet 1994; 343: 1479–1481, [INFOTRIEVE], [CROSSREF], [CSA]
- Edwards C. R., Stewart P. M., Burt D., Brett L., McIntyre M. A., Sutanto W. S., de Kloet E. R., Monder C. Localisation of 11 beta-hydroxysteroid dehydrogenase–tissue specific protector of the mineralocorticoid receptor. Lancet 1988; 2: 986–989, [INFOTRIEVE], [CROSSREF], [CSA]
- Evinger A. J., III, Levin E. R. Requirements for estrogen receptor alpha membrane localization and function. Steroids 2005; 70: 361–363, [INFOTRIEVE], [CROSSREF], [CSA]
- Firth S. M., Baxter R. C. Cellular actions of the insulin-like growth factor binding proteins. Endocr. Rev 2002; 23: 824–854, [INFOTRIEVE], [CROSSREF], [CSA]
- Fitzpatrick J. L., Ripp S. L., Smith N. B., Pierce W. M., Jr., Prough R. A. Metabolism of DHEA by cytochromes P450 in rat and human liver microsomal fractions. Arch. Biochem. Biophys 2001; 389: 278–287, [INFOTRIEVE], [CROSSREF], [CSA]
- Gockerman A., Prevette T., Jones J. I., Clemmons D. R. Insulin-like growth factor (IGF)-binding proteins inhibit the smooth muscle cell migration responses to IGF-I and IGF-II. Endocrinology 1995; 136: 4168–4173, [INFOTRIEVE], [CROSSREF], [CSA]
- Goodwin B., Redinbo M. R., Kliewer S. A. Regulation of cyp3a gene transcription by the pregnane x receptor. Annu. Rev. Pharmacol. Toxicol 2002; 42: 1–23, [INFOTRIEVE], [CROSSREF], [CSA]
- Gordon G. B., Bush D. E., Weisman H. F. Reduction of atherosclerosis by administration of dehydroepiandrosterone. A study in the hypercholesterolemic New Zealand white rabbit with aortic intimal injury. J. Clin. Invest 1988; 82: 712–720, [INFOTRIEVE], [CSA]
- Gu S., Ripp S. L., Prough R. A., Geoghegan T. E. Dehydroepiandrosterone affects the expression of multiple genes in rat liver including 11 beta-hydroxysteroid dehydrogenase type 1: a cDNA array analysis. Mol. Pharmacol 2003; 63: 722–731, [INFOTRIEVE], [CROSSREF], [CSA]
- Hermanowski-Vosatka A., Gerhold D., Mundt S. S., Loving V. A., Lu M., Chen Y., Elbrecht A., Wu M., Doebber T., Kelly L., Milot D., Guo Q., Wang P. R., Ippolito M., Chao Y. S., Wright S. D., Thieringer R. PPARalpha agonists reduce 11beta-hydroxysteroid dehydrogenase type 1 in the liver. Biochem. Biophys. Res. Commun 2000; 279: 330–336, [INFOTRIEVE], [CROSSREF], [CSA]
- Honkakoski P., Negishi M. Protein serine/threonine phosphatase inhibitors suppress phenobarbital-induced Cyp2b10 gene transcription in mouse primary hepatocytes. Biochem. J 1998; 330(2)889–895, [INFOTRIEVE], [CSA]
- Hopper B. R., Yen S. S. Circulating concentrations of dehydroepiandrosterone and dehydroepiandrosterone sulfate during puberty. J. Clin. Endocrinol. Metab 1975; 40: 458–461, [INFOTRIEVE], [CSA]
- Hurst C. H., Waxman D. J. Activation of PPARalpha and PPARgamma by environmental phthalate monoesters. Toxicol. Sci 2003; 74: 297–308, [INFOTRIEVE], [CROSSREF], [CSA]
- Hurst C. H., Waxman D. J. Environmental phthalate monoesters activate pregnane X receptor-mediated transcription. Toxicol. Appl. Pharmacol 2004; 199: 266–274, [INFOTRIEVE], [CROSSREF], [CSA]
- Jamieson P. M., Chapman K. E., Edwards C. R., Seckl J. R. 11 beta-hydroxysteroid dehydrogenase is an exclusive 11 beta-reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations. Endocrinology 1995; 136: 4754–4761, [INFOTRIEVE], [CROSSREF], [CSA]
- Janeczko R., Waxman D. J., Le Blanc G. A., Morville A., Adesnik M. Hormonal regulation of levels of the messenger RNA encoding hepatic P450 2c (IIC11), a constitutive male-specific form of cytochrome P450. Mol. Endocrinol 1990; 4: 295–303, [INFOTRIEVE], [CSA]
- Jenkins P. J. Acromegaly and cancer. Horm. Res 2004; 62(1)108–115, [INFOTRIEVE], [CROSSREF], [CSA]
- Jones S. A., Moore L. B., Shenk J. L., Wisely G. B., Hamilton G. A., McKee D. D., Tomkinson N. C., LeCluyse E. L., Lambert M. H., Willson T. M., Kliewer S. A., Moore J. T. The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. Mol. Endocrinol 2000; 14: 27–39, [INFOTRIEVE], [CROSSREF], [CSA]
- Juge-Aubry C. E., Hammar E., Siegrist-Kaiser C., Pernin A., Takeshita A., Chin W. W., Burger A. G., Meier C. A. Regulation of the transcriptional activity of the peroxisome proliferator-activated receptor alpha by phosphorylation of a ligand-independent trans-activating domain. J. Biol. Chem 1999; 274: 10505–10510, [INFOTRIEVE], [CROSSREF], [CSA]
- Kalimi M., Regelson M. The Biological Role of Dehydroepiandrosterone (DHEA). Walter de Gryter, New York 1990; 1–445
- Kliewer S. A., Goodwin B., Willson T. M. The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. Endocr. Rev 2002; 23: 687–702, [INFOTRIEVE], [CROSSREF], [CSA]
- Klinge C. M. Estrogen receptor interaction with estrogen response elements. Nucleic Acids Res 2001; 29: 2905–2919, [INFOTRIEVE], [CROSSREF], [CSA]
- Kong A. N., Owuor E., Yu R., Hebbar V., Chen C., Hu R., Mandlekar S. Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE). Drug Metab. Rev 2001; 33: 255–271, [INFOTRIEVE], [CROSSREF], [CSA]
- Korach K. S. Estrogen receptor knock-out mice: molecular and endocrine phenotypes. J. Soc. Gynecol. Investig 2000; 7: S16–S17, [INFOTRIEVE], [CROSSREF], [CSA]
- Kotelevtsev Y., Holmes M. C., Burchell A., Houston P. M., Schmoll D., Jamieson P., Best R., Brown R., Edwards C. R., Seckl J. R., Mullins J. J. 11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress. Proc. Natl. Acad. Sci. USA 1997; 94: 14924–14929, [INFOTRIEVE], [CROSSREF], [CSA]
- Kuiper G. G., Carlsson B., Grandien K., Enmark E., Haggblad J., Nilsson S., Gustafsson J. A. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 1997; 138: 863–870, [INFOTRIEVE], [CSA]
- Kuiper G. G., Enmark E., Pelto-Huikko M., Nilsson S., Gustafsson J. A. Cloning of a novel receptor expressed in rat prostate and ovary. Proc. Natl. Acad. Sci. USA 1996; 93: 5925–5930, [INFOTRIEVE], [CSA]
- Kuiper G. G., Gustafsson J. A. The novel estrogen receptor-beta subtype: potential role in the cell- and promoter-specific actions of estrogens and anti-estrogens. FEBS Lett 1997; 410: 87–90, [INFOTRIEVE], [CROSSREF], [CSA]
- Labrie F., Belanger A., Simard J., Van L., Labrie C. DHEA and peripheral androgen and estrogen formation: intracinology. Ann. N. Y. Acad. Sci 1995; 774: 16–28, [INFOTRIEVE], [CSA]
- Lapchak P. A., Araujo D. M. Preclinical development of neurosteroids as neuroprotective agents for the treatment of neurodegenerative diseases. Int. Rev. Neurobiol 2001; 46: 379–397, [INFOTRIEVE], [CSA]
- Lee P. D., Giudice L. C., Conover C. A., Powell D. R. Insulin-like growth factor binding protein-1: recent findings and new directions. Proc. Soc. Exp. Biol. Med 1997; 216: 319–357, [INFOTRIEVE], [CSA]
- Leighton B., Tagliaferro A. R., Newsholme E. A. The effect of dehydroepiandrosterone acetate on liver peroxisomal enzyme activities of male and female rats. J. Nutrition 1987; 117: 1287–1290, [CSA]
- Lemaire G., de Sousa G., Rahmani R. A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides. Biochem. Pharmacol 2004; 68: 2347–2358, [INFOTRIEVE], [CROSSREF], [CSA]
- Lephart E. D., Baxter C. R., Parker C. R., Jr. Effect of burn trauma on adrenal and testicular steroid hormone production. J. Clin. Endocrinol. Metab 1987; 64: 842–848, [INFOTRIEVE], [CSA]
- LeRoith D., Roberts C. T., Jr. The insulin-like growth factor system and cancer. Cancer Lett 2003; 195: 127–137, [INFOTRIEVE], [CSA]
- Levin E. R. Integration of the extranuclear and nuclear actions of estrogen. Mol. Endocrinol 2005; 19: 1951–1959, [INFOTRIEVE], [CROSSREF], [CSA]
- Liu D., Dillon J. S. Dehydroepiandrosterone activates endothelial cell nitric-oxide synthase by a specific plasma membrane receptor coupled to Galpha(i2,3). J. Biol. Chem 2002; 277: 21379–21388, [INFOTRIEVE], [CROSSREF], [CSA]
- Liu D., Dillon J. S. Dehydroepiandrosterone stimulates nitric oxide release in vascular endothelial cells: evidence for a cell surface receptor. Steroids 2004; 69: 279–289, [INFOTRIEVE], [CROSSREF], [CSA]
- Lu S., Archer M. C. Insulin-like growth factor binding protein-1 over-expression in transgenic mice inhibits hepatic preneoplasia. Mol. Carcinog 2003; 36: 142–146, [INFOTRIEVE], [CROSSREF], [CSA]
- Lubet R. A., Gordon G. B., Prough R. A., Lei X. D., You M., Wang Y., Grubbs C. J., Steele V. E., Kelloff G. J., Thomas C. F., Moon R. D. Modulation of methylnitrosourea-induced breast cancer in Sprague Dawley rats by dehydroepiandrosterone: dose-dependent inhibition, effects of limited exposure, effects on peroxisomal enzymes, and lack of effects on levels of Ha-Ras mutations. Cancer Res 1998; 58: 921–926, [INFOTRIEVE], [CSA]
- Maggiolini M., Donze O., Jeannin E., Ando S., Picard D. Adrenal androgens stimulate the proliferation of breast cancer cells as direct activators of estrogen receptor alpha. Cancer Res 1999; 59: 4864–4869, [INFOTRIEVE], [CSA]
- Martin G., Duez H., Blanquart C., Berezowski V., Poulain P., Fruchart J. C., Najib-Fruchart J., Glineur C., Staels B. Statin-induced inhibition of the Rho-signaling pathway activates PPARalpha and induces HDL apoA-I. J. Clin. Invest 2001; 107: 1423–1432, [INFOTRIEVE], [CSA]
- Mattison J. A., Lane M. A., Roth G. S., Ingram D. K. Calorie restriction in rhesus monkeys. Exp. Gerontol 2003; 38: 35–46, [INFOTRIEVE], [CROSSREF], [CSA]
- Masuzaki H., Paterson J., Shinyama H., Morton N. M., Mullins J. J., Seckl J. R., Flier J. S. A transgenic model of visceral obesity and the metabolic syndrome. Science 2001; 294: 2166–2170, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Maurice T., Phan V. L., Urani A., Kamei H., Noda Y., Nabeshima T. Neuroactive neurosteroids as endogenous effectors for the sigmal (sigmal) receptor: pharmacological evidence and therapeutic opportunities. Jpn. J. Pharmacol 1999; 81: 125–155, [INFOTRIEVE], [CROSSREF], [CSA]
- McCormick D. L., Rao K. V., Johnson W. D., Bowman-Gram T. A., Steele V. E., Lubet R. A., Kellof G. J. Exceptional chemopreventive activity of low-dose dehydroepiandrosterone in the rat mammary gland. Cancer Res 1996; 56: 1724–1726, [INFOTRIEVE], [CSA]
- Miller K. K., Cai J., Ripp S. L., Pierce W. M., Jr., Rushmore T. H., Prough R. A. Stereo- and regioselectivity account for the diversity of dehydroepiandrosterone (DHEA) metabolites produced by liver microsomal cytochromes P450. Drug Metab. Dispos 2004; 32: 305–313, [INFOTRIEVE], [CROSSREF], [CSA]
- Mizota K., Yoshida A., Uchida H., Fujita R., Ueda H. Novel type of Gq/11 protein-coupled neurosteroid receptor sensitive to endocrine disrupting chemicals in mast cell line (RBL–2H3). Br. J. Pharmacol 2005; 145: 545–550, [INFOTRIEVE], [CROSSREF], [CSA]
- Moore L. B., Parks D. J., Jones S. A., Bledsoe R. K., Consler T. G., Stimmel J. B., Goodwin B., Liddle C., Blanchard S. G., Willson T. M., Collins J. L., Kliewer S. A. Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J. Biol. Chem 2000; 275: 15122–15127, [INFOTRIEVE], [CROSSREF], [CSA]
- Morton N. M., Holmes M. C., Fievet C., Staels B., Tailleux A., Mullins J. J., Seckl J. R. Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice. J. Biol. Chem 2001; 276: 41293–41300, [INFOTRIEVE], [CROSSREF], [CSA]
- Nestler J. E., Kahwash Z. Sex-specific action of insulin to acutely increase the metabolic clearance rate of dehydroepiandrosterone in humans. J. Clin. Invest 1994; 94: 1484–1489, [INFOTRIEVE], [CSA]
- Ngo T. H., Barnard R. J., Leung P. S., Cohen P., Aronson W. J. Insulin-like growth factor I (IGF-I) and IGF binding protein-1 modulate prostate cancer cell growth and apoptosis: possible mediators for the effects of diet and exercise on cancer cell survival. Endocrinology 2003; 144: 2319–2324, [INFOTRIEVE], [CROSSREF], [CSA]
- Nieschlag E., Loriaux D. L., Ruder H. J., Zucker I. R., Kirschner M. A., Lipsett M. B. The secretion of dehydroepiandrosterone and dehydroepiandrosterone sulphate in man. J. Endocrinol 1973; 57: 123–134, [INFOTRIEVE], [CSA]
- Ogawa S., Chan J., Chester A. E., Gustafsson J. A., Korach K. S., Pfaff D. W. Survival of reproductive behaviors in estrogen receptor beta gene-deficient (betaERKO) male and female mice. Proc. Natl. Acad. Sci. USA 1999; 96: 12887–12892, [INFOTRIEVE], [CROSSREF], [CSA]
- Ogawa S., Chester A. E., Hewitt S. C., Walker V. R., Gustafsson J. A., Smithies O., Korach K. S., Pfaff D. W. Abolition of male sexual behaviors in mice lacking estrogen receptors alpha and beta (alpha beta ERKO). Proc. Natl. Acad. Sci. USA 2000; 97: 14737–14741, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Passilly P., Schohn H., Jannin B., Cherkaoui M. M., Boscoboinik D., Dauca M., Latruffe N. Phosphorylation of peroxisome proliferator-activated receptor alpha in rat Fao cells and stimulation by ciprofibrate. Biochem. Pharmacol 1999; 58: 1001–1008, [INFOTRIEVE], [CROSSREF], [CSA]
- Patterson R. E., Frank L. L., Kristal A. R., White E. A comprehensive examination of health conditions associated with obesity in older adults. Am. J. Prev. Med 2004; 27: 385–390, [INFOTRIEVE], [CROSSREF], [CSA]
- Perks C. M., Newcomb P. V., Norman M. R., Holly J. M. Effect of insulin-like growth factor binding protein-1 on integrin signalling and the induction of apoptosis in human breast cancer cells. J. Mol. Endocrinol 1999; 22: 141–150, [INFOTRIEVE], [CROSSREF], [CSA]
- Peters J. M., Zhou Y. C., Ram P. A., Lee S. S., Gonzalez F. J., Waxman D. J. Peroxisome proliferator-activated receptor alpha required for gene induction by dehydroepiandrosterone-3 beta-sulfate. Mol. Pharmacol 1996; 50: 67–74, [INFOTRIEVE], [CSA]
- Playford M. P., Bicknell D., Bodmer W. F., Macaulay V. M. Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin. Proc. Natl. Acad. Sci. USA 2000; 97: 12103–12108, [INFOTRIEVE], [CROSSREF], [CSA]
- Prough R. A., Lei X. D., Xiao G. H., Wu H. Q., Geoghegan T. E., Webb S. J. Regulation of cytochromes P450 by DHEA and its anticarcinogenic action. Ann. N. Y. Acad. Sci 1995; 774: 187–199, [INFOTRIEVE], [CSA]
- Prough R. A., Webb S. J., Wu H.-Q., Lapenson D., Waxman D. J. Induction of microsomal and peroxisomal enzymes by dehydroepiandrosterone and its reduced metabolite in rats. Cancer Res 1994; 54: 2878–2886, [INFOTRIEVE], [CSA]
- Rainey W. E., Carr B. R., Sasano H., Suzuki T., Mason J. I. Dissecting human adrenal androgen production. Trends Endocrinol. Metab 2002; 13: 234–239, [INFOTRIEVE], [CROSSREF], [CSA]
- Rajkumar K., Modric T., Murphy L. J. Impaired adipogenesis in insulin-like growth factor binding protein-1 transgenic mice. J. Endocrinol 1999; 162: 457–465, [INFOTRIEVE], [CROSSREF], [CSA]
- Rao K. V., Johnson W. D., Bosland M. C., Lubet R. A., Steele V. E., Kelloff G. J., McCormick D. L. Chemoprevention of rat prostate carcinogenesis by early and delayed administration of dehydroepiandrosterone. Cancer Res 1999; 59: 3084–3089, [INFOTRIEVE], [CSA]
- Regelson W., Loria R., Kalimi M. Dehydroepiandrosterone (DHEA)–the “mother steroid”. I. Immunologic action. Ann. N. Y. Acad. Sci 1994; 719: 553–563, [INFOTRIEVE], [CSA]
- Ricketts M. L., Shoesmith K. J., Hewison M., Strain A., Eggo M. C., Stewart P. M. Regulation of 11 beta-hydroxysteroid dehydrogenase type 1 in primary cultures of rat and human hepatocytes. J. Endocrinol 1998; 156: 159–168, [INFOTRIEVE], [CROSSREF], [CSA]
- Ripp S. L., Falkner K. C., Pendleton M. L., Tamasi V., Prough R. A. Regulation of CYP2C11 by dehydroepiandrosterone and peroxisome proliferators: identification of the negative regulatory region of the gene. Mol. Pharmacol 2003; 64: 113–122, [INFOTRIEVE], [CROSSREF], [CSA]
- Ripp S. L., Fitzpatrick J. L., Peters J. M., Prough R. A. Induction of CYP3A expression by dehydroepiandrosterone: involvement of the pregnane X receptor. Drug Metab. Dispos 2002; 30: 570–575, [INFOTRIEVE], [CROSSREF], [CSA]
- Rizner T. L., Lin H. K., Peehl D. M., Steckelbroeck S., Bauman D. R., Penning T. M. Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells. Endocrinology 2003; 144: 2922–2932, [INFOTRIEVE], [CROSSREF], [CSA]
- Robinzon B., Michael K. K., Ripp S. L., Winters S. J., Prough R. A. Glucocorticoids inhibit interconversion of 7-hydroxy and 7-oxo metabolites of dehydroepiandrosterone: a role for 11beta-hydroxysteroid dehydrogenases?. Arch. Biochem. Biophys 2003; 412: 251–258, [INFOTRIEVE], [CROSSREF], [CSA]
- Robinzon B., Prough R. A. Interactions between dehydroepiandrosterone and glucocorticoid metabolism in pig kidney: nuclear and microsomal 11beta-hydroxysteroid dehydrogenases. Arch. Biochem. Biophys 2005; 442: 33–40, [INFOTRIEVE], [CROSSREF], [CSA]
- Rosenfeld R. S., Rosenberg B. J., Hellman L. Direct analysis of dehydroisoandrosterone in plasma. Steroids 1975; 25: 799–805, [INFOTRIEVE], [CROSSREF], [CSA]
- Roth G. S., Lane M. A., Ingram D. K., Mattison J. A., Elahi D., Tobin J. D., Muller D., Metter E. J. Biomarkers of caloric restriction may predict longevity in humans. Science 2002; 297: 811, [INFOTRIEVE], [CROSSREF], [CSA]
- Shalev A., Meier C. A. Peroxisome proliferator-activated receptors: a nuclear hormone receptor involved in adipocyte differentiation and lipid homeostasis. Eur. J. Endocrinol 1996; 134: 541–542, [INFOTRIEVE], [CSA]
- Shen G., Hebbar V., Nair S., Xu C., Li W., Lin W., Keum Y. S., Han J., Gallo M. A., Kong A. N. Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein. J. Biol. Chem 2004; 279: 23052–23060, [INFOTRIEVE], [CROSSREF], [CSA]
- Siddals K. W., Westwood M., Gibson J. M., White A. IGF-binding protein-1 inhibits IGF effects on adipocyte function: implications for insulin-like actions at the adipocyte. J. Endocrinol 2002; 174: 289–297, [INFOTRIEVE], [CSA]
- Sidhu J. S., Omiecinski C. J. An okadaic acid-sensitive pathway involved in the phenobarbital-mediated induction of CYP2B gene expression in primary rat hepatocyte cultures. J. Pharmacol. Exp. Ther 1997; 282: 1122–1129, [INFOTRIEVE], [CSA]
- Strom A., Eguchi H., Mode A., Legraverend C., Tollet P., Stromstedt P. E., Gustafsson J. A. Characterization of the proximal promoter and two silencer elements in the CYP2C11 gene expressed in rat liver. DNA Cell Biol 1994; 13: 805–819, [INFOTRIEVE], [CSA]
- Strom A., Westin S., Eguchi H., Gustafsson J. A., Mode A. Characterization of orphan nuclear receptor binding elements in sex-differentiated members of the CYP2C gene family expressed in rat liver. J. Biol. Chem 1995; 270: 11276–11281, [INFOTRIEVE], [CROSSREF], [CSA]
- Stulnig T. M., Oppermann U., Steffensen K. R., Schuster G. U., Gustafsson J. A. Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity. Diabetes 2002; 51: 2426–2433, [INFOTRIEVE], [CSA]
- Sundseth S. S., Alberta J. A., Waxman D. J. Sex-specific, growth hormone-regulated transcription of the cytochrome P450 2C11 and 2C12 genes. J. Biol. Chem 1992; 267: 3907–3914, [INFOTRIEVE], [CSA]
- Suwanichkul A., DePaolis L. A., Lee P. D., Powell D. R. Identification of a promoter element which participates in cAMP-stimulated expression of human insulin-like growth factor-binding protein-1. J. Biol. Chem 1993; 268: 9730–9736, [INFOTRIEVE], [CSA]
- Swales K., Negishi M. CAR, driving into the future. Mol. Endocrinol 2004; 18: 1589–1598, [INFOTRIEVE], [CROSSREF], [CSA]
- Tomlinson J. W., Walker E. A., Bujalska I. J., Draper N., Lavery G. G., Cooper M. S., Hewison M., Stewart P. M. 11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response. Endocr. Rev 2004; 25: 831–866, [INFOTRIEVE], [CROSSREF], [CSA]
- Ueda H., Inoue M., Yoshida A., Mizuno K., Yamamoto H., Maruo J., Matsuno K., Mita S. Metabotropic neurosteroid/sigma-receptor involved in stimulation of nociceptor endings of mice. J. Pharmacol. Exp. Ther 2001; 298: 703–710, [INFOTRIEVE], [CSA]
- Ueshiba H., Shimizu Y., Hiroi N., Yakushiji F., Shimojo M., Tsuboi K., Miyachi Y. Decreased steroidogenic enzyme 17,20-lyase and increased 17-hydroxylase activities in type 2 diabetes mellitus. Eur. J. Endocrinol 2002; 146: 375–380, [INFOTRIEVE], [CROSSREF], [CSA]
- Vermeulen A., Genazzani A. R. Adrenal androgens and aging. Raven Press, New York 1980; 207–217, (1980)
- Wang J., Niu W., Nikiforov Y., Naito S., Chernausek S., Witte D., LeRoith D., Strauch A., Fagin J. A. Targeted overexpression of IGF-I evokes distinct patterns of organ remodeling in smooth muscle cell tissue beds of transgenic mice. J. Clin. Invest 1997; 100: 1425–1439, [INFOTRIEVE], [CSA]
- Webb S. J., Xiao G. H., Geoghegan T. E., Prough R. A. Regulation of CYP4A expression in rat by dehydroepiandrosterone and thyroid hormone. Mol. Pharmacol 1996; 49: 276–287, [INFOTRIEVE], [CSA]
- Wei E. K., Ma J., Pollak M. N., Rifai N., Fuchs C. S., Hankinson S. E., Giovannucci E. A prospective study of C-peptide, insulin-like growth factor-I, insulin-like growth factor binding protein-1, and the risk of colorectal cancer in women. Cancer Epidemiol. Biomarkers Prev 2005; 14: 850–855, [INFOTRIEVE], [CROSSREF], [CSA]
- Widstrom R. L., Dillon J. S. Is there a receptor for dehydroepiandrosterone or dehydroepiandrosterone sulfate?. Semin. Reprod. Med 2004; 22: 289–298, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
- Williams L. J., Lyons V., MacLeod I., Rajan V., Darlington G. J., Poli V., Seckl J. R., Chapman K. E. C/EBP regulates hepatic transcription of 11beta -hydroxysteroid dehydrogenase type 1. A novel mechanism for cross-talk between the C/EBP and glucocorticoid signaling pathways. J. Biol. Chem 2000; 275: 30232–30239, [INFOTRIEVE], [CROSSREF], [CSA]
- Wu H. Q., Masset-Brown J., Tweedie D. J., Milewich L., Frenkel R. A., Martin-Wixtrom C., Estabrook R. W., Prough R. A. Induction of microsomal NADPH-cytochrome P-450 reductase and cytochrome P-450IVA1 (P-450LA omega) by dehydroepiandrosterone in rats: a possible peroxisomal proliferator. Cancer Res 1989; 49: 2337–2343, [INFOTRIEVE], [CSA]
- Yamaguchi Y., Tanaka S., Yamakawa T., Kimura M., Ukawa K., Yamada Y., Ishihara M., Sekihara H. Reduced serum dehydroepiandrosterone levels in diabetic patients with hyperinsulinaemia. Clin. Endocrinol. (Oxf) 1998; 49: 377–383, [CROSSREF], [CSA]
- Yau J. L., Noble J., Kenyon C. J., Hibberd C., Kotelevtsev Y., Mullins J. J., Seckl J. R. Lack of tissue glucocorticoid reactivation in 11beta-hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments. Proc. Natl. Acad. Sci. USA 2001; 98: 4716–4721, [INFOTRIEVE], [CROSSREF], [CSA]
- Yoneyama A., Kamiya Y., Kawaguchi M., Fujinami T. Effects of dehydroepiandrosterone on proliferation of human aortic smooth muscle cells. Life Sci 1997; 60: 833–838, [INFOTRIEVE], [CROSSREF], [CSA]