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Journal of the American College of Nutrition Volume 26, 2007 - Issue 2
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Original Research

Multivitamin-Mineral Supplementation Prevents Lipid Peroxidation during “The Marathon des Sables”

Guillaume Machefer Laboratory of Physiology and Biomechanics of Muscular Exercise, UFR-APS, University of Rennes 2 (G.M., C.G., S.V., H.Z., A.G.-D.); G.I.S. Sciences of Movement (G.M., C.G., S.V., H.Z., J.C., A.G.-D.)Correspondence[email protected]
, PhD,
Carole Groussard Laboratory of Physiology and Biomechanics of Muscular Exercise, UFR-APS, University of Rennes 2 (G.M., C.G., S.V., H.Z., A.G.-D.); G.I.S. Sciences of Movement (G.M., C.G., S.V., H.Z., J.C., A.G.-D.)
, PhD,
Sophie Vincent Laboratory of Physiology and Biomechanics of Muscular Exercise, UFR-APS, University of Rennes 2 (G.M., C.G., S.V., H.Z., A.G.-D.); G.I.S. Sciences of Movement (G.M., C.G., S.V., H.Z., J.C., A.G.-D.)
, PhD,
Hassane Zouhal Laboratory of Physiology and Biomechanics of Muscular Exercise, UFR-APS, University of Rennes 2 (G.M., C.G., S.V., H.Z., A.G.-D.); G.I.S. Sciences of Movement (G.M., C.G., S.V., H.Z., J.C., A.G.-D.)
, PhD,
Henri Faure Department of Integrated Biology, CHUG, Grenoble (H.F.), FRANCE
, PhD,
Josiane Cillard G.I.S. Sciences of Movement (G.M., C.G., S.V., H.Z., J.C., A.G.-D.); Laboratory of Cellular and Plant Biology, Faculty of Pharmacy, University of Rennes 1 (J.C.), Rennes Cedex
, PhD,
Zsolt Radák Department of Exercise Physiology, School of Sport Science, Semmelweiss University Budapest, Budapest, HUNGARY (Z.R.)
, PhD &
Arlette Gratas-Delamarche Laboratory of Physiology and Biomechanics of Muscular Exercise, UFR-APS, University of Rennes 2 (G.M., C.G., S.V., H.Z., A.G.-D.); G.I.S. Sciences of Movement (G.M., C.G., S.V., H.Z., J.C., A.G.-D.)
, PhD show all
Pages 111-120 | Received 04 Dec 2004, Accepted 25 Jul 2006, Published online: 14 Jun 2013
 
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Abstract

Objective: We investigated the effect of a moderate mutivitamin and mineral supplementation containing mainly vitamin C (150.0 mg.day−1), vitamin E (24.0 mg.day−1) and β-carotene (4.8 mg.day−1) prior to and during an extreme running competition -the Marathon des Sables (MDS)- that consisted of six long races in the desert.

Methods: Seventeen athletes participated in our double blind, placebo-controlled study. Blood samples were collected prior to the supplementation i.e. three weeks before the competition (D-21), two days prior to the MDS (D-2), after the third race (D3) and at the end of the competition (D7). Erythrocyte antioxidant enzyme activity (glutathione peroxidase (GPx), superoxide dismutase (SOD)), erythrocyte glutathione level (GSH), plasma non-enzymatic antioxidant status (uric acid, vitamin C, α-tocopherol, retinol, β-carotene), markers of plasma lipid peroxidation (thiobarbituric reactive substances (TBARS)), reactive carbonyl derivatives (RCD) and membrane damage (creatine kinase and lactate dehydrogenase activities) were measured.

Results: In both groups, GSH levels, uric acid levels and membrane damage significantly increased during the competition while SOD activity significantly decreased. In Supplemented group, plasma α-tocopherol, β-carotene and retinol levels significantly increased after three weeks of supplementing. In contrast to Placebo group, α-tocopherol, vitamin C and retinol levels were significantly affected by the competition in Supplemented group. Moreover, no increase in TBARS was observed in Supplemented group during the competition, whereas TBARS significantly increased at D3 in the placebo group.

Conclusion: The moderate multivitamin-mineral supplementation prevented the transient increase in TBARS levels during this extreme competition.

The authors thank Martine Chevanne, Maria Sasvari, Dominique Paul, Marie-Thérèse Gougeon, Martine Godard and Michelle Jester for their technical assistance.

The authors thank the Hemocue® company for its hiring of equipment.

The authors thank the Doc Trotter association and especially Patrick Germanèze for their help during the “Marathon des Sables.”

Notes

This research was supported by NHS Laboratory, Paris, Rungis, France.

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