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Abstract
As an important cell factory, industrial yeast has been widely used for the production of compounds ranging from bulk chemicals to complex natural products. However, various adverse conditions including toxic products, extreme pH, and hyperosmosis etc., severely restrict microbial growth and metabolic performance, limiting the fermentation efficiency and diminishing its competitiveness. Therefore, enhancing the tolerance and robustness of yeasts is critical to ensure reliable and sustainable production of metabolites in complex industrial production processes. In this review, we provide a comprehensive review of various strategies for improving the tolerance of yeast cells, including random mutagenesis, system metabolic engineering, and material-mediated immobilization cell technology. It is expected that this review will provide a new perspective to realize the response and intelligent regulation of yeast cells to environmental stresses.
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Acknowledgements
This work was supported by National Key R & D Program of China (2019YFA0905700), National Natural Science Foundation of China (22078151, 22178169), Jiangsu Natural Science Fund for Distinguished Young Scholars (BK20220052), the Taishan Industrial Experts Program, Jiangsu Agricultural Science and Technology Independent Innovation Fund Project (CX (21)3120), Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture (XTD2215), and Young Elite Scientist Sponsorship Program by CAST (YESS20200174).
Disclosure statement
No potential conflict of interest was reported by the author(s)