Disease Control in Patients with Asthma is Associated with Alexithymia but not with Depression or Anxiety

Abstract

This observational cohort study investigated the relationship between alexithymia, coping strategies, anxiety, depression, pulmonary function, and disease control in bronchial asthma (BA) patients who attended a tertiary care center between December 2010 and November 2011. Participants (N = 117) were administered self-report scales measuring anxiety, depression, alexithymia, and coping strategies. Pulmonary function expressed as forced expiratory volume in the first second (FEV₁), forced vital capacity (FVC), forced expiratory flow rate over the middle 50% of the FVC (FEF_25–75) as% predicted and FEV₁/FVC as%, fractional exhaled nitric oxide (FeNO) in ppb and the Asthma Control Test (ACT) were recorded. A hierarchical cluster analysis revealed two clusters of patients with different FEV₁ values (p < .001) and alexithymia scores (p < .001). The cluster with lower FEV₁ and higher alexithymia used more maladaptive coping strategies (p < .05), and had lower ACT scores (p < .05). Alexithymia was significantly associated with the severity of depression and anxiety symptoms (p < .001 for each comparison). In BA patients, alexithymia was associated with worse pulmonary function and disease control and a more frequent use of maladaptive coping strategies. These results support a multidimensional approach to asthmatic patients, including psychoeducational and behavioral interventions aimed at reducing maladaptive coping strategies.

Keywords:

• alexithymia
• asthma control test
• bronchial asthma
• coping strategies
• pulmonary function