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Journal of Biomaterials Science, Polymer Edition Volume 31, 2020 - Issue 14
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Articles

The bactericidal potential of LLDPE with TiO2/ZnO nanocomposites against multidrug resistant pathogens associated with hospital acquired infections

Nor Hazliana HarunOncological and Radiological Sciences Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Kepala Batas, Pulau Pinang, Malaysia; ORCID Iconhttps://orcid.org/0000-0002-5563-4145View further author information
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Rabiatul Basria S. M. N MydinOncological and Radiological Sciences Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Kepala Batas, Pulau Pinang, Malaysia; ;Department of Biological Sciences, National University of Singapore, Singapore, Singapore; Correspondence[email protected]
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Srimala SreekantanSchool of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, Nibong Tebal, Pulau Pinang, Malaysia; View further author information
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Khairul Arifah SaharudinSchool of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, Nibong Tebal, Pulau Pinang, Malaysia; ;Qdos Interconnect Sdn. Bhd, George Town, Pulau Pinang, Malaysia; View further author information
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Norfatehah BasironSchool of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, Nibong Tebal, Pulau Pinang, Malaysia; View further author information
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Azman SeeniIntegrative Medicine Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Kepala Batas, Pulau Pinang, Malaysia; ;Malaysian Institute of Pharmaceuticals and Nutraceuticals (IPHARM), National Institute of Biotechnology Malaysia, Ministry of Science, Technology and Innovation, Gelugor, Pulau Pinang, MalaysiaView further author information
Pages 1757-1769 | Received 02 Sep 2019, Accepted 26 May 2020, Published online: 26 Jun 2020
 
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Abstract

The emerging polymer nanocomposites have received industrial interests in diverse fields because of their added value in metal oxide-based nanocomposites, such as titanium (TiO2) and zinc oxide (ZnO). Linear low-density polyethylene (LLDPE)-based polymer has recently generated a huge market in the healthcare industry. TiO2 and ZnO are well known for their instant photocatalytic killing of hospital-acquired infections, especially multidrug-resistant (MDR) pathogens. This study investigated the actions of LLDPE/TiO2/ZnO (1:3) nanocomposites in different weight% against two representative MDR pathogens, namely, methicillin-resistant Staphylococcus aureus (MRSA) and Klebsiella pneumonia (K.pneumoniae). Antibacterial activities were quantified according to international standard guidelines of CLSI MO2-A11 (static condition) and ASTM E-2149 (dynamic condition). Preliminary observation via a scanning electron microscope revealed that LLDPE matrix with TiO2/ZnO nanocomposites changed the bacterial morphology and reduced the bacterial adherence and biofilm formation. Furthermore, a high ZnO weight ratio killed both types of pathogens. The bactericidal potential of the nanocomposite is highlighted by the enhancements in photocatalytic activity, zinc ion release and reactive species, and bacteriostatic/bactericidal activity against bacterial growth. This study provides new insights into the MDR-bactericidal potential of LLDPE with TiO2/ZnO nanocomposites for targeted healthcare applications.

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

This research was funded by the Ministry of Education (MOE) Malaysia under Transdisciplinary Research Grant Scheme (TRGS) grant no. 6769003.

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