Potential implications of polyphenolic compounds in neurodegenerative diseases

Abstract

Neurodegenerative diseases are common chronic diseases related to progressive damage to the nervous system. Current neurodegenerative diseases present difficulties and despite extensive research efforts to develop new disease-modifying therapies, there is still no effective treatment for halting the neurodegenerative process. Polyphenols are biologically active organic compounds abundantly found in various plants. It has been reported that plant-derived dietary polyphenols may improve some disease states and promote health. Emerging pieces of evidence indicate that polyphenols are associated with neurodegenerative diseases. This review aims to overview the potential neuroprotective roles of polyphenols in most common neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, epilepsy, and ischemic stroke.

Keywords:

• Alzheimer’s disease
• epilepsy
• ischemic stroke
• Parkinson’s disease
• Polyphenols

Authors contribution

MJ conceptualized the idea. RDS and DLG wrote the manuscript. MJ, RS, KCL, and AS revised and provided critical comments. All the authors have approved the manuscript.

Disclosure statement

No potential conflict of interest was reported by the authors.

Data availability statement

The datasets generated during and/or analyzed during the current study are available from the corresponding author upon reasonable request.

Additional information

Funding

This work was supported by the Belt and Road Innovative Foreign Experts Project (No. DL2021023004L) and Jinan Talent Project for Universities (No. 2021GXRC106 and 2021GXRC111). We are also grateful for grants from Shandong High-end Foreign Experts Recruitment Program (No. WST2019006 and WST2020008).