In the article, Cytotoxic C-Methylated Chalcones from Syzygium samarangense., by E.C. Amor et al., published in Pharmaceutical Biology, 45(10): 777–783, the following revisions have been made:
The IC12 of compound 2 against the RAD52 mutant strain should be 252 μ M while that of the positive control, streptonigrin should be 0.008 μ M. In addition, compound 2 was not cytotoxic against the LF15 wild-type strain that is why it was concluded that it exhibited selective cytotoxicity towards the mutant strain.
Table 3 should be modified according to the table below, which indicates the correct IC50 values of the compounds and the positive control. The IC50 values obtained are rough estimates that are based on two concentrations, 50 μ.g/mL and 5 μ.g/mL, due to limited sample availability.
The concentrations at which compounds 2 and 5 are cytotoxic against normal and breast cancer cells should be 167.8 μ M and 16.7 μ M, respectively. Compounds 1 and 3 showed slight toxicity against normal and breast cancer cells at a concentration of 167.8 μ M while 4 is cytotoxic at 17.5 μ M.
The chalcone counterpart of dihydrochalcone 4 is compound 3 and not compound 1.