Resolvin inflammation with pain

Abstract

Background: Inflammation and pain coexist in conditions such as arthritis, inflammatory bowel disease and lower back pain. The drugs currently used to treat the combination of inflammation and pain all have disadvantages. Thus, new drugs and new approaches are needed to treat inflammation with pain. Resolvins are considered to be part of the natural resolving mechanism for inflammation and have been shown to prevent inflammation in animal models.

Objectives/methods: To evaluate a paper suggesting that the resolvins RvE1 and RvD1 attenuate inflammatory pain in animal models.

Results: RvE1 has been shown to attenuate inflammation and, to a lesser extent, pain in animal models. Limited results are presented of the effectiveness of RvD1 against inflammatory pain.

Conclusion: Drugs that mimic or potentiate the effects of the resolvins may be useful for the treatment of some inflammation with pain.

Keywords::

• animal models
• inflammation
• pain
• resolvins
• RvD1
• RvE1