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Volume 19, Issue 11

Expert Opinion on Investigational Drugs

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Expert Opinion on Investigational Drugs, Volume 19, Issue 11 (2010)

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Expert Opinion on Investigational Drugs, Volume 19, Issue 11 (2010)

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Reviews

Article

5-HT₃ antagonists under development

Youhoon Chong & Hyunah Choo

Pages: 1309-1319

Published online: 15 Oct 2010

Abstractfor5-HT₃ antagonists under development | Full Text | References | PDF (402.5 KB)

226 Views
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Article

Tumor vasculature as target for therapeutic intervention

Marcel HAM Fens, Gert Storm & Raymond M Schiffelers

Pages: 1321-1338

Published online: 15 Oct 2010

AbstractforTumor vasculature as target for therapeutic intervention | Full Text | References | PDF (648.7 KB)

155 Views
17 CrossRef citations
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Article

Overcoming platinum resistance in ovarian carcinoma

Koji Matsuo MD, Yvonne G Lin MD MS, Lynda D Roman MD & Anil K Sood MD

Pages: 1339-1354

Published online: 06 Sep 2010

AbstractforOvercoming platinum resistance in ovarian carcinoma | Full Text | References | PDF (383.5 KB)

432 Views
80 CrossRef citations
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Article

Akt inhibitors in clinical development for the treatment of cancer

Sumanta Kumar Pal MD, Karen Reckamp MD MS, Hua Yu PhD & Robert A Figlin MD FACP

Pages: 1355-1366

Published online: 16 Sep 2010

AbstractforAkt inhibitors in clinical development for the treatment of cancer | Full Text | References | PDF (331.5 KB)

1030 Views
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Article

Pharmacological small molecules for the treatment of lysosomal storage disorders

BE Smid, JMFG Aerts, RG Boot, GE Linthorst & CEM Hollak

Pages: 1367-1379

Published online: 13 Oct 2010

AbstractforPharmacological small molecules for the treatment of lysosomal storage disorders | Full Text | References | PDF (572.7 KB)

357 Views
33 CrossRef citations
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Article

Targeting the MET oncogene in cancer and metastases

Giulia M Stella MD PhD, Silvia Benvenuti PhD & Paolo M Comoglio MD PhD

Pages: 1381-1394

Published online: 26 Sep 2010

AbstractforTargeting the MET oncogene in cancer and metastases | Full Text | References | PDF (470.4 KB)

517 Views
39 CrossRef citations
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Article

Novel therapeutic strategies targeting vascular endothelium in essential hypertension

Dimitris Tousoulis MD PhD FACC, Nikolaos Papageorgiou MD, Emmanouil Androulakis MD, Kiriaki Paroutoglou MD & Christodoulos Stefanadis MD FACC

Pages: 1395-1412

Published online: 05 Oct 2010

AbstractforNovel therapeutic strategies targeting vascular endothelium in essential hypertension | Full Text | References | PDF (331.6 KB)

123 Views
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Drug Evaluations

Article

Temporal aspects of the action of ASA404 (vadimezan; DMXAA)

Bruce C Baguley & Dietmar W Siemann

Pages: 1413-1425

Published online: 21 Oct 2010

AbstractforTemporal aspects of the action of ASA404 (vadimezan; DMXAA) | Full Text | References | PDF (550.3 KB)

246 Views
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Article

Avanafil, a new rapid-onset phosphodiesterase 5 inhibitor for the treatment of erectile dysfunction

Ma Limin, Niels Johnsen & Wayne JG Hellstrom

Pages: 1427-1437

Published online: 13 Oct 2010

AbstractforAvanafil, a new rapid-onset phosphodiesterase 5 inhibitor for the treatment of erectile dysfunction | Full Text | References | PDF (257.4 KB)

785 Views
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Article

PLX4032: does it keep its promise for metastatic melanoma treatment?

Elisabeth Livingstone MD, Lisa Zimmer MD, Sarah Piel MD & Dirk Schadendorf MD

Pages: 1439-1449

Published online: 14 Oct 2010

AbstractforPLX4032: does it keep its promise for metastatic melanoma treatment? | Full Text | References | PDF (513.1 KB)

492 Views
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Article

Nalmefene for treatment of alcohol dependence

Michael Soyka & Susanne Rösner

Pages: 1451-1459

Published online: 25 Sep 2010

AbstractforNalmefene for treatment of alcohol dependence | Full Text | References | PDF (245.6 KB)

558 Views
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Key Paper Evaluation

Article

Resolvin inflammation with pain

Evaluation of: Xu ZZ, Zhang L, Liu T, et al. Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. Nat Med 2010;16:592-7

Sheila A Doggrell PhD DSc

Pages: 1461-1464

Published online: 14 Oct 2010

AbstractforResolvin inflammation with pain | Full Text | References | PDF (170.7 KB)

107 Views
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