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Expert Review of Vaccines Volume 5, 2006 - Issue 4
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Review

Antigen-specific T-cell-mediated immunity after HIV-1 infection: implications for vaccine control of HIV development

Michael R Betts University of Pennsylvania, Department of Microbiology, 522E Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA. [email protected]
,
Clive M Gray National Institute for Communicable Diseases, AIDS Unit, Private Bag X4, Sandringham 2131, Johannesburg, South Africa. [email protected]
,
Josephine H Cox Walter Reed Army Institute of Research, Chief Cellular Immunology Section, Division of Retrovirology, US Military HIV Research Program, Suite 200, 13 Taft Court Rockville, MD 20850, USA. [email protected]
&
Guido Ferrari Duke University Medical Center, Department of Experimental Surgery, P.O. Box 2926 Durham, NC 27710, USA. [email protected]
Pages 505-516 | Published online: 09 Jan 2014
 
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Abstract

The definition of immune correlates of protection in HIV-1 infection is pivotal to the design of successful vaccine candidates and strategies. Although significant methodological and conceptual strides have been made in our understanding of HIV-specific cellular immunity, we have not yet defined those parameters that have a role in controlling the spread of HIV infection. This review discusses the basis of our understanding of HIV-specific cellular immunity and identifies its shortcomings. Furthermore, potential protective characteristics will be proposed that may ultimately be required for an effective vaccine designed to stimulate cellular immunity against HIV-1.

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