Peculiar features and tailored management of adult cancers occurring in pediatric age

Abstract

Most of the tumors typical of adult age, that is, gastrointestinal cancers, melanoma, lung and breast cancers, and carcinomas of the head and neck, may also occur – albeit very rarely – in children, and pediatric oncologists have defined them as ‘rare (or very rare) pediatric tumors’. Given the scarce data available in the literature, the clinical management of children with these tumor types is a real challenge for pediatric oncologists and surgeons. Adult tumors often differ in many aspects from the malignancies typical of pediatric age, and the diagnostic and treatment guidelines adopted for children when they develop ‘adult’ cancers are generally extrapolated from those applied to adults. However, the biology and clinical course of some adult tumors seem to change when they occur in children, thus suggesting the need for tailored approaches. This article describes a few such tumors and points to the need for forms of international cooperation with a view to gaining a better understanding of these particular conditions and improving patient management.

Keywords::

• adult cancer
• children
• colorectal cancer
• gastrointestinal stromal tumors
• hepatocellular carcinoma
• melanoma
• nasopharyngeal carcinoma
• rare pediatric tumors
• thyroid cancer
• TREP project

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.