Multiple myeloma with dural mater involvement

Abstract

Multiple myeloma is an incurable clonal B-cell malignancy which may present with neoplastic monoclonal plasma cells in either bone or soft tissues. Central nervous system (CNS) involvement such as dural myeloma or intraparenchymal infiltration, or with diffuse leptomeningeal involvement, is uncommon. Dural involvement of myeloma without parenchymal or leptomeningeal disease is an even rarer occurrence; therefore there are no established treatment guidelines for CNS myelomatosis. Here we reported a refractory MM patient progressed to dura mater involvement after the induction therapy but showed good response to lenalidomide treatment.

Keywords:

• multiple myeloma
• dura mater involvement
• lenalidomide

Multiple myeloma (MM) is a malignant neoplasm of plasma cells, generally located in the bone marrow (BM).¹ Extramedullary plasmacytoma (EMP) can arise at any time during the course of the disease,² with the most frequent involved metastases being the head and neck region (sinuses, naso-, and oropharynx), gastrointestinal tract, and lungs.^3,4 Intracranial and central nervous system (CNS) involvement are rare, accounting for approximately 1% of MM patients, while dura mater involvement is even rarer.^5,6 Here, we present a case of refractory MM patient progressed to dura mater involvement after the induction therapy.

A 49-year-old woman presented with a 4-month history of right rib pain. ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography (PET)–computed tomography (CT) showed increased FDG uptake in multiple bones with a soft tissue mass on the right fifth rib. The laboratory findings were as follows: serum immunofixation electrophoresis (SIFE) revealed IgD-λ type monoclonal immunoglobulin; serum-free λ light chain 645 mg/L, κ/λ ratio 0.0108; CBC counts revealed hemoglobin (Hb) 119 g/L, white blood cell (WBC) count 4.43×10⁹/L, platelet count 210×10⁹/L; beta-2 microglobulin 3.52 mg/L, LDH 188U/L. Flow cytometry of the BM showed 8.15% plasma cells with the immunophenotype CD138+, CD38+, cLambda+, CD200+, CD19−, CD20−, CD45−, CD56−, and cKappa−. BM biopsy showed 80% lambda-restricted, CD138 and CD38 double-positive plasma cells. The patient was diagnosed as IgD-λ MM in June 2018 (Durie–Salmon stage IIIA, ISS stage II). After two cycles of PAD (bortezomib 1.3 mg/m² on days 1, 4, 8, and 11; liposomal doxorubicin 30 mg/m² on day 1; dexamethasone 20 mg on days 1–2, 4–5, 8–9, and 11–12) treatment, she achieved partial response (PR). Another two cycles of PAD regimen was given to her.

But after the induction treatment, she complained of progressive jaw numbness and mild dysphagia. Laboratory tests were as follows: CBC counts revealed Hb 83 g/L, WBC count 4.81×10⁹/L, platelet count 40×10⁹/L; SIFE revealed IgD-λ-type monoclonal immunoglobulin; serum-free λ light chain 267.5 mg/L, κ/λ ratio 0.0239. BM aspirate showed no abnormal plasma cells. Flow cytometry of the BM showed 2.22% lambda-restricted, CD138- and CD38-positive plasma cells. She denied any history of head trauma. Enhanced magnetic resonance imaging (MRI) of the head revealed thickening of dural mater with enhanced signal indicating metastasis of malignant plasma cells, but the tissue biopsy was not attempted due to low platelet count (Figure 1A). Flow cytometry of the cerebrospinal fluid (CSF) showed no plasmacytosis. According to the results of the examination, her disease was progressed. Aggressive systemic therapy that crosses the blood–brain barrier was implemented, ie, lenalidomide 25 mg on days 1–21, cyclophosphamide 500 mg on days 1, 8, 15 and 21, and dexamethasone 30 mg on days 1–4 and 12–15 (RCD). After one cycle of RCD treatment, all the symptoms disappeared and the platelet count increased to normal. Serum-free λ light chain decreased to 51.6 mg/L. The enhanced MRI of the head revealed a considerable decrease in the size of the dural masses with a significant weak signal (Figure 1B).

Figure 1 (A) The MRI of the patient when neurological symptoms appeared. (B) The MRI of the patient after treatment.

Abbreviation: MRI, magnetic resonance imaging.

CNS involvement of myeloma is rare, generally located in brain parenchyma, pia, and dura mater. Amyloid deposition may be seen in dura-associated PCM. It is seldom that dura mater is the only involved area, with few cases reported; most were women with IgG-κ isotype.^7–9 The case we present is the only one with IgD-λ isotype, and with only dura mater involvement without cranial nerve or subdural hemorrhage complications.

The prognosis of MM patients with CNS involvement is poor.^10,12 All the cases reported previously died soon after meningeal metastases, with a median survival time 0.1–3 months, except one case reported by Roddiehad.¹² The patient he reported had a favorable response to combined chemotherapy (methotrexate, idarubicin, and dexamethasone) and cranial radiotherapy.¹³

Because of the low incidence, there is no treatment guideline for patients with CNS involvement. The appropriate treatment may include intrathecal chemotherapy and systemic chemotherapy that cross the blood–brain barrier, with or without cranial irradiation.⁵ Although prognosis is generally poor, the survival of previously untreated patients and patients with favorable cytogenetic profile might be prolonged due to systemic treatment and/or radiotherapy,¹⁴ and new agents plus SCT appear to represent optimal treatment.¹⁵ There are some new potentionally effective drugs like pomalidomide, marizomib, and daratumumab.^16–18 In this case, the patient was resistant to bortezomib and liposomal doxorubicin, and her platelet count was very low, indicating she was unable to endure the standard chemotherapy. So lenalidomide, cyclophosphamide, and dexamethasone were given to her. The neurologic symptoms disappeared after one cycle treatment; however, her response to RCD regimen need further evaluation.

Ethics approval and consent to participate

The patient has given her written informed consent to publish the case (including publication of images). The study protocol was approved by the institution committee on human research of the Tianjin Medical University Cancer Institute and Hospital.

Author contributions

All authors contributed to data analysis, drafting or revising the article, gave final approval of the version to be published, and agree to be accountable for all aspects of the work.

Availability of data and materials

The material supporting the conclusion of this case has been included within the article.

Acknowledgments

This work was supported by grants 81670104 from the National Natural Science Foundation of China (NSFC).

Disclosure

The authors report no conflicts of interest in this work.