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Abstract
The study investigates the association of polymorphism in glutathione S-transferases (GSTs) with susceptibility for head and neck squamous cell carcinoma (HNSCC) and its sites as well as treatment response in cases receiving chemotherapy (CT) and combination of CT-radiotherapy (CT-RT).
The case-control study included 500 male cases and an equal number of healthy male controls. Odds ratios (ORs) and 95% confidence intervals (95% CI) were calculated for the association between genotypes and cancer risk.
An increase in the risk for HNSCC and cancers of oral cavity, larynx or pharynx was observed in cases with null genotypes of GSTM1 or GSTT1. The interaction of alcohol or tobacco with variant genotypes of GSTM1 or GSTT1 also resulted in a significant increase in the risk for HNSCC. Further, HNSCC cases carrying the null genotypes of GSTM1 and GSTT1 or variant genotypes of GSTP1 showed a significant and superior treatment response.
The present data thus provides evidence for the association of polymorphisms in GSTs with risk for HNSCC and its treatment response.
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Acknowledgements
The authors are grateful to the Director of IITR, Lucknow for his keen interest in carrying out the study. Mr. Munindra Ruwali is grateful to UGC, New Delhi for providing a Senior Research Fellowship. The technical assistance of Mr. B. S. Pandey and Mr. Rajesh Misra and computer help of Mr. Mohd. Aslam is also gratefully acknowledged.
Declaration of interest
The authors report no conflicts of interest. The financial support of CSIR Suprainstitutional Project (SIP-08) in carrying out the above studies is gratefully acknowledged. IITR Communication Number 2863.