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Endocrine Research Volume 35, 2010 - Issue 3
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Research Article

The Hypothalamic–Pituitary–Adrenal Axis in Women with Differentiated Thyroid Cancer

Alexandra Chrisoulidou Unit of Endocrinology and Endocrine Oncology, Theagenio Hospital, Thessaloniki, GreeceCorrespondence[email protected]
,
Kalliopi Pazaitou-Panayiotou Unit of Endocrinology and Endocrine Oncology, Theagenio Hospital, Thessaloniki, Greece
,
Eleni Georgiou Unit of Endocrinology and Endocrine Oncology, Theagenio Hospital, Thessaloniki, Greece
,
Maria Boudina Unit of Endocrinology and Endocrine Oncology, Theagenio Hospital, Thessaloniki, Greece
,
Konstantinos Lytras Unit of Radiology, Theagenio Hospital, Thessaloniki, Greece
,
Ioannis Iakovou Unit of Endocrinology and Endocrine Oncology, Theagenio Hospital, Thessaloniki, Greece
,
Iraklis Vainas Unit of Endocrinology and Endocrine Oncology, Theagenio Hospital, Thessaloniki, Greece
&
Gregory Kaltsas Unit of Pathophysiology, University of Athens, Laiko Hospital, Athens, Greece
 show all
Pages 137-143 | Received 11 Aug 2010, Accepted 25 May 2010, Published online: 16 Aug 2010
 
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Abstract

Introduction. We studied the function of hypothalamic–pituitary–adrenal (HPA) axis in females with differentiated thyroid cancer (DTC) and its sequelae on metabolism and cardiovascular risk. Methods and Results. Sixteen women were investigated with (Citation) morning, evening, and midnight cortisol and adrenocortophic hormone, (Citation) cortisol after overnight 1 mg dexamethasone suppression test, (Citation) cortisol after corticotropin releasing hormone test, (Citation) oral glucose tolerance test with glucose and insulin estimations, and (Citation) ultrasound for carotid intima media thickness. A matched control group underwent similar investigations. None of the parameters was significantly different between patients and controls. Conclusion. Females with DTC have normal HPA-axis function and similar insulin sensitivity and cardiovascular risk compared to controls.

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