Selenium and Hormone Interactions in Female Patients with Hashimoto Disease and Healthy Subjects

Abstract

Objective. To examine the correlation structure of parameters expressing selenium status, sex hormones secretion and thyroid function in a group of patients with Hashimoto disease and healthy female subjects. Method. Partial Least Square modeling was applied to parameters under study. Results. The correlations between relevant parameters were confirmed. Selenoenzyme glutathione peroxidase (GPX3) an progesterone played the most significant roles among factors contributing to thyroid stimulating hormone and free thyroxine regulation. Additionally, a correlation between GPX3 and estradiol was also observed which is in agreement with results reported by other authors. Patients with Hashimoto disease had lower glutathione peroxidase activities than healthy subjects. Conclusion. The integrated multivariate approach applied to a new group of patients dissimilar to the previous one, was validated by statistical adequacy as well ass meaningful interpretation.

Keywords:

• Selenium
• Thyroid Function
• Sex Hormones
• Hashimoto Disease

ACKNOWLEDGEMENTS

This work was supported in part by grant no. K/ZDS/000594. We are sincerely grateful to Dr. M. Daszykowski from Department of Chemometrics, University of Silesia, for providing us with his software for computing rPCA. Mr. M. Paszcza, CTO, from MP System Co. is appreciated for generously delivered software for calculations of correlation weights.

DECLARATION OF INTEREST

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Notes

¹The angle determined by two lines connecting the origin with coordinates of both parameters on the PLS “final plot.”