Erratum

This article refers to:

Functional food ingredients as adjunctive therapies to pharmacotherapy for treating disorders of metabolic syndrome

Christopher P. F. Marinangeli & Peter J. H. Jones: Functional food ingredients as adjunctive therapies to pharmacotherapy for treating disorders of metabolic syndrome. Ann Med 2010; 42: 317–333.

It has come to our attention that the top-most oval in Figure 1 should have read ‘Atherogenic Dyslipidemia’ as shown below:

Figure 1. MetS as a multifaceted disease encompassing central obesity, atherogenic dyslipidemia, hypertension, and insulin resistance. Low antioxidant status can contribute to the development of hypertension and insulin resistance, while hypercholesterolemia, specifically high LDL-C, is a primary target for atherogenic dyslipidemia.

It has come to our attention that the mechanisms for prescription medications in Table VI should have been depicted as shown below:

Table VI. Summary comparison of blood pressure-lowering mechanisms between lycopene and tomato extracts and prescription medications.

Hypertension Functional food and nutraceuticals		Prescription medication
Tomato extract and lycopene:		ACE inhibitor:
↑ Antioxidant defenses	}↓ Vasoconstriction	↓ Angiotensin II production
↑ Nitric oxide levels?		Angiotensin II receptor antagonist
↓ Peroxynitrate formation		Inhibits angiotensin II from binding to its receptor in vascular smooth muscle
		Calcium blockers:
		↓ Cardiac and arteriole muscle contraction
		β-Blockers:
		↓ Cardiac output
		↓ Renin release
		Thiazides:
		Diuretics
		↓ Sodium reabsorption

On page 327, the third sentence of the ‘Medications versus tomato extract as adjunctive therapies for hypertension’ section should have read as follows:

In the same study, it should be noted that the 6% and 5% reductions in SBP and DBP observed with tomato extract are comparable to average reductions in SBP and DBP with prescription medications at 8.8 mmHg and 4.4 mmHg for thiazides, 9.2 mmHg and 6.7 mmHg for β-blockers, 8.5 mmHg and 4.7 mmHg for ACE inhibitors, 10.3 mmHg and 5.7 mmHg for angiotensin II-converting enzyme antagonists, and 8.8 mmHg and 5.9 mmHg for calcium blockers, respectively (139)—thus suggesting that concentrated tomato extract can complement hypotensive medications.

The authors, editors and publisher sincerely regret any inconvenience this may have caused our readers.