Associations between interleukin-23R and interleukin-12B polymorphisms and psoriasis susceptibility: a meta-analysis

Abstract

Objective: The aim of this study was to determine whether interleukin (IL)-23 R and IL-12B polymorphisms confer susceptibility to psoriasis.

Methods: The authors conducted a meta-analysis on associations between the IL-23 R and IL-12B polymorphisms and psoriasis susceptibility.

Results: A total of 14 comparison studies were included in this meta-analysis. The meta-analysis identified a significant association between psoriasis and 2 alleles of the rs11209026 and rs7530511 polymorphisms in Europeans (odds ratio [OR] = 0.624, 95% confidence interval [CI] = 0.565–0.697, p < 1.0 × 10⁻⁸; OR = 0.804, 95% CI = 0.743–0.869, p = 3.0 × 10⁻⁷, respectively). Meta-analysis of IL-12B showed a significant association between the 2 alleles of the rs6887695 and rs3212227 polymorphisms and the risk of developing psoriasis (OR = 0.710, 95% CI = 0.673–0.749, p < 1.0 × 10⁻⁸; OR = 0.684, 95% CI = 0.639–0.731, p < 1.0 × 10⁻⁸, respectively). Stratification by ethnicity identified an association between the rs6887695 and rs3212227 polymorphisms and psoriasis in Europeans.

Conclusions: This meta-analysis showed that the IL-23 R (rs11209026 and rs7530511) polymorphisms are associated with psoriasis risk in Europeans and that the IL-12B (rs6887695 and rs3212227) polymorphisms are associated with susceptibility to psoriasis in Europeans.

• Interleukin-23 R
• interleukin-12B
• Meta-analysis
• Polymorphism
• Psoriasis

Acknowledgements

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.