Spectrofluorimetric determination of dl-N-methyl-3-phenyl-3-[(α,α,α-trifluoro-p-tolyl)oxy]propylamine in pharmaceuticals and chitosan solution

Abstract

A spectrofluorimetric method for the determination of d,l-N-methyl-3-phenyl-3-[(α,α,α-trifluoro-p-tolyl)oxy]propylamine, fluoxetine (F), in pharmaceuticals was evaluated in the 50.0–500.0 μg ml^{− 1} range. Linearity, sensibility, quantification and detection limit, and precision values are satisfactory. The method does not need pre-treatment and was successfully applied to the determination in pharmaceuticals and chitosan (Ch) solution. Ch has an ability to carry and absorb fat and may eventually be used together with F in slimming diets, and then interactions of Ch–F may occur. This work seeks to study these interactions by monitoring the photophysics of a drug in the presence of Ch. The results warn about the care that must be taken when both compounds are prescribed together.

Keywords::

• fluoxetine
• chitosan
• spectrofluorimetry
• anti-depressive drug

Declaration of interest: The author thanks CNPq and FAPESP for the financial support. The author reports no conflicts of interest. The author alone is responsible for the content and writing of the paper.