Coffee bean polyphenols ameliorate postprandial endothelial dysfunction in healthy male adults

Abstract

To reveal the effect of coffee bean polyphenols (CBPs) on blood vessels, this study aimed to investigate the effect of CBPs on acute postprandial endothelial dysfunction. Thirteen healthy non-diabetic men (mean age, 44.9 ± 1.4 years) consumed a test beverage (active: containing CBPs, placebo: no CBPs) before a 554-kcal test meal containing 14 g of protein, 30 g of fat and 58 g of carbohydrates. Then, a crossover analysis was performed to investigate the time-dependent changes in flow-mediated dilation (FMD) in the brachial artery. In the active group, the postprandial impairment of FMD was significantly improved, the two-hour postprandial nitric oxide metabolite levels were significantly increased and the six-hour postprandial urinary 8-epi-prostaglandin F2α levels were significantly reduced compared to the placebo group. The test meal increased the levels of blood glucose, insulin and triglycerides in both groups with no significant intergroup differences. These findings indicate that CBPs intake ameliorates postprandial endothelial dysfunction in healthy men.

• Chlorogenic acid
• coffee
• endothelial function
• flow-mediated dilation
• nitric oxide
• polyphenol

Acknowledgements

The authors thank the subjects, the professional physicians and Ms. S. Tsurimaki, who participated in this study, for their cooperation.

Declaration of interest

This study was supported financially by Kao Corporation. Ryuji Ochiai, Yoko Sugiura, Kazuhiro Otsuka and Yoshihisa Katsuragi are Kao Corporation employees.